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Multimodal neuroimaging investigation of post-stroke fatigue in middle-aged and older adults: combining resting-state fMRI and DTI-ALPS analysis
CONCLUSION: This multimodal neuroimaging study highlights altered brain functional connectivity and glymphatic dysfunction as potential neural correlates of PSF in middle-aged and older adults. The findings provide novel insights into the complex pathophysiology of PSF in the aging brain, implicating both functional brain networks and the glymphatic system. Further research is warranted to validate these age-specific findings and explore targeted interventions for PSF in older stroke survivors.