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Aging reshapes global disease burdens, yet the regulatory roles of long non-coding RNAs (lncRNAs) in age-related disorders remain incompletely characterized. We developed iLDA-SGCN, a graph-based computational framework that integrates singular value decomposition (SVD) with dual graph convolutional networks (GCNs) to predict lncRNA-disease associations. SVD first derives compact low-dimensional representations from the lncRNA-disease association matrix. Two complementary GCN modules then learn...

Excessive alcohol consumption poses significant health risks and is closely associated with oxidative damage. The KEAP1-NRF2-ARE signaling pathway serves as the primary antioxidant system. However, current small molecule inhibitors are all covalently bound to KEAP1, meaning that once bound, they are not easily dissociated, while continuous inhibition of KEAP1 exhibits severe side effects. In this study, BLI, CETSA, Pull-down, Co-IP, and HDX-MS assay analysis were conducted to detect the KEAP1...

CONCLUSIONS: Maintaining favorable long-term patterns of PA, even with gradual decline, is associated with reduced odds of DS among older adults with chronic diseases. These findings support PA as a potentially cost-effective strategy for secondary prevention and highlight the importance of sustained behavioral patterns in mitigating mental health risks in aging populations.

CONCLUSION: Frailty is common among Iranian older adults and is independently associated with poorer physical QoL and, to a lesser extent, mental QoL. These findings support the need for targeted screening and multidomain interventions.

As online support for the experts spreads, ADA members have resigned from their positions

Science chats with researchers about a new method of assessing canine “handedness” and what it reveals about your pup’s health and personality