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Head start: fossil clues about how bodies evolved from two-fold to five-fold symmetry
Bug bites convince UK doctor to support mosquito research centre
Emerging strategies, applications and challenges of targeting NAD<sup>+</sup> in the clinic
The X-Age Project to construct a Chinese aging clock
Towards a personalized approach in senolytic trials
AI chatbots are already biasing research — we must establish guidelines for their use now
A revolution is sweeping Europe’s farms: can it save agriculture?
Global geopolitics should not stall science — 5 ways to push back
Strengthen the science behind the Agreement on Fisheries Subsidies
Life scientists: educate others to help strengthen biosecurity
Use computing royalties to kick-start biodiversity fund
Creativity is essential to the ethos of universities
Remembering David Baltimore, a titan who transformed biology and spoke bluntly
The influential Nobel laureate ran institutions, trained future scientific leaders, survived a scandal, and shaped policy
Microscopic robots navigate ‘artificial spacetimes’
Light-guided bots are steered through mazes like spacecraft tugged by gravity
A role for lithium in Alzheimer disease
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COVID-19 accelerates vascular aging
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Cerebrospinal fluid draining lymphatics in health and disease: advances and controversies
The meninges, consisting of the dura, arachnoid and pia mater that surround the brain and spinal cord, have been recognized from the earliest anatomical studies. First identified in 1787, lymphatic vessels in the dura are now receiving greater attention as their contribution to cerebrospinal fluid (CSF) clearance in diverse neurological conditions is being investigated. New methods have increased the understanding of dural lymphatics, but much is still being learned about their heterogeneity,...
Enhancing healthspan with Ashwagandha (Withania somnifera): a comprehensive review of its multifaceted geroprotective benefits
Ashwagandha (Withania somnifera), a revered herb in Ayurvedic medicine, has gained significant scientific recognition for its potential to promote healthy aging. Traditionally used as a Rasayana or rejuvenator, this potent adaptogen helps the body manage stress and enhance vitality. This review synthesises extensive evidence for its multifaceted anti-aging capabilities, which target key hallmarks of the aging process. The mechanisms underpinning its effects include enhancing telomerase activity...
The proBNPage reduction (PBAR) trial-results of a randomized, double blind, placebo-controlled, pilot study to fine tune an NT-proBNP-based method to assess the effect of anti-aging treatments
NT-proBNP levels increase exponentially with age and are associated with cardiovascular and all-cause mortality. From NT-proBNP concentration a surrogate for biological age ("proBNPage") can be obtained. The primary objective of this study was to define a method to design future trials on anti-aging treatments using proBNPage. The secondary objective was the tentative evaluation of 4 potential anti-aging dietary supplements. The trial lasted 2 years and involved 120 healthy subjects aged 71.7 ±...
Impact of regular televisits on unplanned hospital admissions of nursing home residents in rural Germany: a pre-post intervention study
CONCLUSIONS: Implementing regular televisits in the nursing home setting reduced the number of hospital admissions. This is most likely due to more frequent medical assessment, enabling early detection and timely management of deteriorations. By preventing unnecessary hospital admissions residents were spared the physical and psychological burdens connected with emergency transfers and protected from hospital-associated risks. On top of enhancing quality of care for the residents, televisits...