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CONCLUSION: This cross-sectional study found a significant association between proximity to major roadways and prevalent diabetes in Chinese older adults. Roadway proximity acts as a composite surrogate marker of traffic hazards, neighborhood socioeconomic deprivation and built environments, rather than merely traffic pollution or noise. These findings guide future environmental and health equity research on seniors. Longitudinal studies with objective exposure measurements are required to...

Nicotinamide adenine dinucleotide (NAD^(+)) is an essential metabolite that regulates diverse cellular metabolic processes. Primary cilia, hair-like organelles on the cell surface, function as critical signaling hubs. Here, we demonstrate that cellular NAD^(+) levels are key regulators of both primary cilia growth and lysosomal function in hypothalamic neurons. NAD^(+) depletion induces ciliary shortening and diminishes lysosomal activity in a cilia-dependent manner. Mechanistically, the...

Calcific aortic valve disease (CAVD) is an age-associated valvular disorder in which calcification expands from discrete foci into adjacent tissue. We investigated whether mitochondrial-derived vesicles (MDVs) released by human valvular interstitial cells (hVICs) exert pro-calcific effects on recipient cells and how MDV release is regulated. Using ex vivo hemodynamic perfusion of human CAVD tissue, multi-omics profiling, live-cell single-organelle tracking, MDV transfer assays, and in vivo Gas6...

Patients with idiopathic pulmonary fibrosis (IPF) are highly vulnerable to respiratory virus infections, but the cellular mechanisms linking fibrotic remodeling to impaired local antiviral defense remain unclear. Here, we investigated how cellular senescence shapes the response of patient-derived healthy (HLF) and IPF primary lung fibroblasts to influenza A virus (IAV) infection. Transcriptomic profiling identified infection as the driver of gene expression in both DNA damage-induced senescent...

INTRODUCTION: Easy-to-Read (E2R) formatting is widely recommended to improve reading accessibility, yet whether its typographic and structural features benefit visual processing and comprehension across the adult lifespan remains unclear.

CONCLUSION: Social engagement appears to be a critical pathway to health, even if sedentary. Nonetheless, natural spaces are chosen environments for a range of OOH activities. We recommend neighbourhoods be designed with multifunctional natural spaces to encourage mobility during OOH trips, supporting ageing-in-place.

Genome aging refers to age-related acquisition and expansion of de novo mutations in somatic cells, and is now increasingly viewed as a central driver of organismal aging. Loss of X chromosome (LOX), the state in which one X chromosome (ChrX) is missing, represents the most common genetically inferred type of acquired mutation in women. Recent technological advancements, along with the growing availability of large-scale cohorts for association studies, have provided powerful new insights into...

X-ray experiments reveal cubic crystals that could complicate the picture of the inner core

Researchers estimate climate change is responsible for two-thirds of the deaths

A natural compound extracted from a medicinal plant has shown surprising promise against rheumatoid arthritis. In rats, it reduced joint swelling, protected cartilage, and calmed the immune responses responsible for chronic inflammation. Scientists discovered that the compound works by targeting a specific protein and restoring balance to fatty acid metabolism, revealing a previously underexplored way to fight the disease.

A simple, steroid-free procedure could offer lasting relief for people struggling with carpal tunnel syndrome, potentially helping them avoid surgery. In a clinical trial involving 63 patients, researchers found that ultrasound-guided hydrodissection, which uses fluid to free a compressed nerve in the wrist, provided longer-lasting improvements in pain, numbness, and hand function than traditional steroid injections.

Scientists stress need for further study of Shamonda virus but say there’s no cause for alarm

Researchers analyzing nearly 150,000 Reddit posts uncovered unexpected symptom reports linked by users to unapproved versions of retatrutide, including increased appetite, sleep disturbances, and elevated heart rates. The findings differ from clinical trial results and highlight how AI could help identify potential drug safety signals that warrant further investigation.

Tam Dao, who investigated foreign attempts to obtain U.S.-funded research, now has a grant to determine the extent of the threat