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Ageing is the most prominent risk factor for Alzheimer's disease (AD). However, the cellular mechanisms linking neuronal proteostasis decline to the characteristic aberrant protein deposits in the brains of patients with AD remain elusive. Here we develop transdifferentiated neurons (tNeurons) from human dermal fibroblasts as a neuronal model that retains ageing hallmarks and exhibits AD-linked vulnerabilities. Remarkably, AD tNeurons accumulate proteotoxic deposits, including phospho-tau and...

No abstract

Adeno-associated viral (AAV) vectors are an ideal platform for gene therapy due to their ability to deliver therapeutic cargos safely and effectively across various target organs. Their low immunogenicity contributes to long-lasting therapeutic effects. However, recent insights highlight the significance of CpG content within AAV vectors, where unmethylated CpG dinucleotides can trigger a TLR9-mediated immune response, leading to the rapid elimination of transduced cells. Clinical evidence...

CONCLUSIONS: The risk of osteoporosis is independently associated with the prediction of mortality. The OSTA may serve as a suitable predictor for mortality related to osteoporosis among the Asian population.

CONCLUSION: Moderate and light physical activity in older adults alleviates depression and improves instrumental activities of daily living (IADLs), and light physical activity improves the level of activities of daily living (ADLs).

Terminated grants include efforts to get students and underrepresented groups involved in science

Follow President Donald Trump’s impact on U.S. research and science globally

NIH takes smaller hit than some other parts of HHS

Science, Volume 387, Issue 6741, Page 1367-1369, March 2025.

Science, Volume 387, Issue 6741, Page 1356-1358, March 2025.

Science, Volume 387, Issue 6741, Page 1363-1366, March 2025.

Science, Volume 387, Issue 6741, Page 1343-1346, March 2025.