Aging & Longevity

Handgrip strength (HGS) declines with age and is associated with morbidity and mortality. This study aimed to investigate sex-specific associations between absolute and allometric HGS and all-cause mortality in Mexican adults aged 50 years and older. We analyzed data from the Mexican Health and Aging Study, including 1917 adults aged ≥ 50 years with HGS assessed at wave 3. Absolute HGS (kg) and allometric HGS (HGS/height²) were examined using sex-specific quartiles and standardized z-scores....

Psychosocial stress is a risk factor for aging-related diseases. The COVID-19 pandemic placed a psychosocial burden on individuals, potentially increasing the risk for aging-related diseases for which epigenetic clocks are used as early biomarkers. Based on four epigenetic clocks (DunedinPACE, GrimAge2, Horvath, and PedBE), we investigated whether epigenetic aging changed during the pandemic and whether these changes were associated with objective and subjective pandemic-related stressors and...

Age-related decline in male fertility, including diminished sperm quality, poses significant risks to offspring health and is exacerbated by modern trends toward delayed parenthood. Focusing on the hypothalamus-pituitary-testis axis, which governs hormonal control of male reproduction, we identified Synage, a long noncoding RNA expressed in the hypothalamic medial preoptic area (mPOA). We found that Synage expression in gonadotropin-releasing hormone (GnRH) neurons decreases with age,...

This paper uses newly harmonized survey and register data on incomes and labor market outcomes as the basis for consistent comparisons of inequalities across 17 North American and European countries over the period 1995-2021. We examine trends in disposable income inequality in the working-age population, defined as persons aged 25 to 60, as well as its component parts of market income inequality and redistribution through government tax and transfer systems. We adjust incomes to allow for...

Senescent cells play important roles in various biological processes that promote fitness and health; however, their timely elimination by immune cells is critical to maintain tissue homeostasis and prevent disease. Despite this, senescent cells accumulate systemically with age, suggesting that certain immune cells also become senescent and dysfunctional during aging. In support of this, we previously demonstrated that CD8 T cells, immune cells capable of targeting senescent cells, increasingly...

CONCLUSION: Nicotine attenuated selected D-galactose-associated behavioral and hippocampal alterations. The genotype comparisons support α7-nAChR-associated modulation of platform-site crossings, serum GSH, and hippocampal IBA1. They do not establish that changes in brain GSH or amyloid production mediate these effects, or that all nicotine responses share one receptor-dependent mechanism.

Age-related declines in pulmonary function and immune regulation increase morbidity and mortality in older adults. Physical activity mitigates these effects, but the isolated impact of resistance training (RT) on lung function and immune responses remains unclear. Sixty-nine older adults without participation for at least one year in structured exercise programs (aged 60-85 years) were recruited from a community extension program at a Brazilian university and randomized into an RT group (n = 31)...

CONCLUSIONS: Older adults with higher mortality risk had poorer social wellbeing at baseline and were more likely to become lonely and decrease social participation at follow-up. Prognostic information may help clinicians avoid low-value medical interventions while prioritizing interventions to support meaningful social connection.

ObjectiveTo examine the association between early-life circumstances and healthy aging among community-dwelling older Chinese adults.MethodsData were from the China Health and Retirement Longitudinal Study. We used regression methods to identify independent and joint associations of six early-life factors with healthy aging as assessed by the Chinese Healthy Aging Index (CHAI; 0-12), a composite score evaluating six physiological systems.ResultsOf 3,069 participants, 4.82% had the healthiest...

ObjectivesUsing longitudinal data, we investigate changes in coresidence preference of Chinese older adults and, with application of the Andersen-Newman framework, examine factors contributing to coresidence preference.MethodsData come from five waves of the Chinese Longitudinal Healthy Longevity Survey collected between 2005 and 2018. A random-effect model uses baseline covariates to predict coresidence preference at follow-up between two adjacent waves, controlling for baseline preference and...

There is an urgent global need for affordable, large-scale health screening to enhance preventive care in the ageing population. Using low-cost, non-invasive retinal photographs and leveraging large foundation models, we developed a deep learning-based biomarker, Retinal Mortality Equivalent (RetiME), that directly mapped retinal features to individual mortality risk. Trained on a European cohort and externally validated across three independent external cohorts spanning Southeast Asia, Eurasia...

Assessing and validating circulating biomarkers is essential for developing preclinical measures of biological aging in mice. However, comprehensive serum proteomics are limited by technical challenges and low sample volumes. Here we present a quantitative nanoparticle-based enrichment workflow coupled with data-independent acquisition mass spectrometry for deep proteomic profiling of low-volume mouse serum. This approach increased proteomic coverage by 3-6-fold with median coefficient of...

Iron accumulation is a conserved hallmark of cellular as well as organismal aging, yet its mechanistic role in senescence remains largely elusive. Here we show that the accumulation of ferrous iron (Fe^(2+)) in lysosomes, a unique feature of senescent cells, is crucial for the induction of multiple senescence-associated phenotypes. Intriguingly, we found that this lysosomal Fe^(2+) sequestration is rendered "safe" by a dual metabolic adaptation that confers robust resistance to ferroptosis....

Reproductive aging impairs female fertility, and oocyte aging is considered a major driver of this phenotype, which manifests with increased aneuploidy and miscarriage risk, while no effective treatments have been widely implemented to date. Here, we report comprehensive protein expression profiling of oocytes during human aging, comparing fully grown germinal vesicle oocytes (FGO) and metaphase II (MII) oocytes; we describe the effect of aging on the maturation profiles across multiple age...

CONCLUSION: The Korean short-form AARC is better interpreted as a subscale-based measure than as a single total score. Further validation and refinement are needed, particularly regarding selected item wording, item coverage, response category functioning, and subgroup comparability, before the scale is used for precise individual-level assessment.

When subject to damage or stress, cells develop responses in order to maintain tissue homeostasis. Two such responses are ferroptosis and cellular senescence, but how cells decide between these outcomes remains unclear. Here, we show that senescent cells increase import and membrane levels of multiple polyunsaturated fatty acids (PUFAs), but a specific intermediate PUFA, dihomo-gamma-linolenic acid (DGLA, 20:3ω-6), is reduced. Exogenous repletion of DGLA instead results in cell death by...

The major characteristics of cellular senescence are stable cell-cycle arrest, accumulation of DNA damage responses, mitochondrial dysfunction, metabolic remodeling, and the release of pro-inflammatory senescence-associated secretory phenotype (SASP) factors. Redox imbalance plays a significant role in the initiation and maintenance of senescence, and the mammalian thioredoxin system-comprising cytosolic Trx-1, mitochondrial Trx-2, thioredoxin reductases (TrxR1, TrxR2), and the inhibitor...

Chromatin stability and nuclear architectural integrity constitute the primary defense against cellular senescence. Their collapse precipitates genomic disarray, epigenetic misregulation, and functional decline in stem cells. Although TOP2A is conventionally known for resolving DNA topological stress, its role in aging remains largely unexplored. Here, we found that TOP2A expression progressively decreased in senescent mesenchymal stem cells (MSCs), and its depletion initiated a catastrophic...

Epigallocatechin gallate (EGCG), a major tea polyphenol, has been proposed to promote healthy aging, but population-level evidence and underlying mechanisms remain unclear. We analyzed 10,977 participants from the National Health and Nutrition Examination Survey (NHANES) and conducted mechanistic studies in Caenorhabditis elegans and AML12 hepatocytes. Compared with non-consumers, both lower and higher EGCG intake categories were associated with lower PhenoAge acceleration, lower all-cause...

We developed a machine learning framework grounded in a computational model of brain function and FDG-PET imaging to predict Alzheimer's disease (AD)-type tau across AD and related disorders (ADRD). The model was trained on 1088 research participants spanning normal aging and ADRD with FDG-PET and flortaucipir-PET (FTP-PET). Validation was conducted in: (1) a longitudinal subset of the training cohort (n = 215), (2) Alzheimer's Disease Neuroimaging Initiative (n = 295), and (3) a heretogeneous...