Aging & Longevity

In the context of cognitive neuroscience research on aging, older women are often overrepresented in observational research, whereas men are overrepresented in clinical trials. Factors underlying the selection bias between and across genders in research on aging are currently poorly understood. Addressing this knowledge gap is critical to provide guidance on how we might mitigate selection bias and improve the generalizability, robustness, and reproducibility of our findings. We aimed to...

Adiponectin is an adipose tissue-derived peptide hormone that exerts beneficial metabolic effects in many tissues throughout the body. It is most well-known for its ability to enhance insulin sensitivity and dampen chronic inflammation. The impact of age on adiponectin is controversial; levels of adiponectin in circulation in older individuals have been linked to both positive and negative effects. This review integrates genetic, mechanistic, and therapeutic perspectives on adiponectin in aging....

The abundance, dynamics, and context-dependent heterogeneity of DNA methylation, where a pattern considered abnormal in one cell type may be normal in another, complicate the identification of early methylation changes that drive or signal disease development. This complexity can obscure early markers of increased disease risk, making it challenging to detect and intervene in disease processes at their inception. Here, we report 31,744 CpG loci exhibiting highly consistent methylation profiles...

Extracellular vesicles (EVs) are key mediators of intercellular communication and may reflect physiological changes during aging. We analyzed plasma-derived EVs from a healthy aging cohort stratified by age, using size exclusion chromatography, surface profiling, nanoparticle tracking, and small RNA sequencing. While EV size and concentration remained largely unchanged, older individuals showed shifts in EV immunophenotype consistent with immunosenescence and displayed distinct miRNA signatures...

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ObjectivesPhysical health often declines with age, yet subjective well-being (SWB) tends to remain stable. Stereotype Embodiment Theory proposes that internalized self-perceptions of aging (SPAs) shape how physical changes are interpreted. This study tested whether SPA buffered the affective impact of health decline. The role of SPA was tested in midlife and late adulthood.MethodsData came from the ILSE, a population-based study of 1,002 adults initially aged 40 or 60 and followed for 20 years....

This study examined hypothesized differences across males and females in the relationship between cognitive trajectories and mortality in older adults. Data were drawn from the ZARADEMP study on dementia and depression in adults aged 55 and older in Zaragoza, Spain. A total of 2403 cognitively healthy individuals who completed at least three of four waves over a 12-year follow-up were included. Cognitive trajectories were derived from Mini-Mental State Examination (MMSE) scores. Using growth...

Aging-associated sarcopenia is driven in part by the progressive loss of type II glycolytic fibers and the functional decline of their resident stem cells, the satellite cells (SCs). We show here that these defects result from attenuation of the hypoxia-inducible factor-1α (HIF-1α) signaling pathway and can be reversed by pharmacological HIF-1α reactivation. In the tibialis anterior muscle of 18-month-old C57BL/6J mice, HIF-1α protein abundance decreased by ≈46% and canonical targets (Vegfa,...

Ageing entails a variety of cellular and physiological changes that increase susceptibility to disease and death. A significant contributor to ageing is cellular senescence, a state of irreversible cell cycle arrest triggered by stressors such as DNA damage, telomere shortening, and the senescence-associated secretory phenotype. It is challenging to understand the nonlinear interactions between these complex mechanisms using conventional laboratory approaches. Mathematical modelling is capable...

Ischemic stroke (IS) is a cerebrovascular disorder that, if left untreated, can lead to secondary neurodegeneration and Post Stroke Cognitive Impairment (PSCI). Current therapies offer a narrow time window, highlighting the need for alternative approaches. Flavonoids, known for their neuroprotective properties, are promising candidates. Chrysin, a flavone with multiple pharmacological activities, was investigated for its therapeutic role in IS and PSCI. Pharmacokinetic and toxicological profiles...

Copper (Cu)-based single-atom catalysts (SACs) enable electrocatalytic CO(2) reduction into methane (CH(4)) fuel for thermal power plant decarbonization, yet conventional Cu SACs face industrial deployment barriers like instability and sluggish kinetics caused by d - p orbital coupling. Herein, we develop a Cu-Ti(1)O(3) catalyst with localized Cu single-atom sites by oxygen vacancy (O(v))-involved orbital engineering, achieving industrial-level CH(4) production. Theoretical and in-situ studies...

The aging population experiences concurrent brain aging and deterioration of bone health. Imaging-derived brain age gap (BAG) demonstrates enhanced predictive capacity for age-related pathologies compared to chronological age. This study included 28,705 participants who underwent brain MRI at a mean age of 63.2 years, with brain age predicted from 1705 imaging-derived phenotypes using LASSO regression (mean predicted brain age: 63.2 years). We then assessed the associations of BAG with BMD at 4...

Arms races between parasites and hosts are key drivers of evolution. Selfishly replicating transposable elements (TEs) are thought to follow similar dynamics, but strong evidence is missing. We test this in termites, social insects in which TEs have been linked to ageing. Sequencing genomes and profiling DNA methylation across the termite phylogeny reveal corresponding phylogenetic signals in TEs and TE methylation, indicative of co-evolution. TE methylation reduces TE success, as both TE...

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Older individuals exhibit distinct biochemical and functional changes in their immune cells that can lead to chronic inflammation, reduced immunity to pathogens and organ dysfunction. Immune cells from older individuals acquire dysfunctional immunosenescent phenotypes that are classified as inflammatory, exhausted or senescent. Key molecular mechanisms, commonly described as hallmarks of ageing, drive the development of these phenotypes through both cell-autonomous and non-autonomous mechanisms....

CONCLUSIONS: Improving food access for older adults requires a multilevel approach. The government should ensure inclusive food welfare, while communities should develop local systems to support older adults, especially those facing food shortages.

CONCLUSION: This study provides an integrated and stage-specific understanding of life satisfaction among older Chinese adults. The findings deepen the theoretical understanding of life course influences, social support, and psychological resilience in later life. The study also suggests the need for tailored policy interventions that prioritize mental health care, social engagement, and basic living conditions at lower satisfaction levels, and incorporate early-life experiences and emotional...

Associations between healthy dietary patterns and life expectancy remain unclear. Here, we reported the prospective associations of five dietary patterns with mortality and life expectancy in 103,649 UK Biobank participants. Over a median follow-up period of 10.6 years, 4314 total deaths were documented. Alternate Healthy Eating Index-2010, Alternate Mediterranean Diet (AMED), healthful Plant-based Diet Index (hPDI), Dietary Approaches to Stop Hypertension, and Diabetes Risk Reduction Diet...

The gradual decline in thymic function with age, known as age-related thymic involution, leads to reduced T cell production, thereby increasing the risk of infections and cancer susceptibility and leading to poor vaccine responses. Moreover, T cell defects were recently involved in the age-related loss of tissue integrity and function. Mechanistically, thymic involution is driven by several factors, including hormonal modifications and chronic inflammation, leading to functional changes in the...

Telomere shortening is a hallmark of aging and has been implicated in cardiovascular disease, but its mechanistic link to atrial fibrillation (AF) remains elusive. Using a high-throughput, single-gene-calibrated dot blot assay, we developed to quantify leukocyte telomere length (LTL). In age-stratified analyses, shorter LTL was associated with AF predominantly in individuals younger than 70 years. In telomerase-deficient (TERT^(-/-)) mice with telomere dysfunction, higher AF inducibility, atrial...