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Scientists discovered that disrupting the chemical messages bacteria use to communicate can push dental plaque toward a healthier microbial balance. The approach could lead to new treatments for gum disease that control harmful bacteria without destroying beneficial species.

Cannabinoids may intensify anxiety by removing a natural brake on specific neurons in the brain’s fear center, particularly during stressful situations. In mice, shutting down those neurons sharply reduced cannabinoid-related anxious behavior.

Colorectal cancer in young people is often diagnosed at an advanced stage, with researchers finding most patients age 21 or younger already had Stage III or IV disease. Because symptoms like rectal bleeding, weight loss, abdominal pain, and bowel changes may be overlooked, researchers are calling for greater vigilance.

Scientists have found a surprising way to regrow damaged knee cartilage by blocking a protein that becomes more abundant with age. In old mice, the treatment restored naturally lost cartilage and also helped prevent osteoarthritis after ACL-like knee injuries, while human cartilage taken from knee replacement patients began producing new, functional joint cartilage after exposure to the same inhibitor.

Couples who exercise together report better communication, healthier conflict resolution, and lower marital stress than those who work out alone. Even something as simple as taking a walk together may create valuable opportunities to talk, listen, and feel more connected.

New mothers paired with patient navigators were much more likely to receive postpartum care, depression screening, preventive testing, and ongoing primary care. By helping with barriers such as transportation, childcare, scheduling, and confusing medical information, navigators may provide a powerful way to improve women’s long-term health.

Canine models are invaluable for translational geroscience, but natural sex-associated immune aging remains under investigated. Here, we characterize the age-associated hematologic and serum cytokine profiles in a controlled cross-sectional cohort of 80 intact laboratory Beagles spanning 1 to 11 years of age. Canine immune aging is heterogeneous and non-linear. While several absolute leukocyte counts declined with age before rising again in geriatric dogs, serum cytokines exhibited distinct,...

Systemic aging alters ocular structures and plasma metabolome, yet relationships between multidimensional biological aging, environmental exposomes, plasma metabolism, and retinal changes remain uncharacterized. This study evaluated how these phenotypic networks align with retinal structural variations. Following rigorous screening, 45,542 UK Biobank participants (2006-2010) were analyzed. Systemic aging was quantified using PhenoAge acceleration, Klemera-Doubal method age acceleration (KDM-BA),...

γδ T cells have an unconventional biology as they develop as functional cells in the thymus, to thereafter adapt to postnatal cues and persist into adulthood in peripheral blood. Single-cell transcriptomics enables investigation of underlying molecular programs of γδ T cell effector functions in health and disease. However, the effect of age is often underestimated, and control transcriptome datasets of young healthy individuals are rare. Here, we generate a cost-effective single-cell...

CONCLUSIONS: CKMAI is a valid, CKM‑specific aging index that outperforms universal biological age measures in predicting mortality and identifying high‑risk CKM status. Its super‑additive interactions with PhenoAge and the partial mediation by depression offer new mechanistic insights into CKM heterogeneity. By integrating a diverse set of clinical laboratory measures, nutritional assessments, lifestyle factors, and social determinants of health, CKMAI provides a practical, implementable tool...

Late-onset preeclampsia (LOPE) is a major pregnancy complication characterized by hypertension and placental dysfunction, resolving only upon delivery. Here, we show that LOPE placentae undergo accelerated molecular aging, marked by telomere attrition, DNA damage, and trophoblast senescence. Using primary placental tissue and trophoblast organoids, we demonstrate oxidative stress as a driver of telomere shortening and angiogenic imbalance. Inflammation did not alter placental aging trajectories....

Brain ageing is a complex physiological process characterised by progressive structural and functional changes that often result in cognitive decline and reduced quality of life in the elderly. These changes are driven by multiple mechanisms, including synaptic dysfunction, oxidative stress, neuroinflammation, and impaired cellular homeostasis. Neuropeptides have emerged as important regulators of these processes. Among them, neuropeptide Y (NPY) has gained attention for its potential role in...

CONCLUSION: The maps document a WoS-derived and PubMed-verified literature corpus concentrated on TDP-43 and ALS/FTD and increasingly connected with cryptic RNA processing, condensate biology, nuclear transport, neuroimmune responses, and aging-related mixed proteinopathies. Because the corpus was conditioned by a title-level query containing named RBPs and by PubMed record verification, these patterns should not be interpreted as an unbiased ranking of RBP biology or as evidence of shared...

Aging is a major risk factor in the development of type 2 diabetes mellitus (T2DM). With age, pancreatic β-cells undergo functional and cell identity changes that can compromise insulin secretion, thereby contributing to impaired glucose tolerance and T2DM. However, glucose homeostasis also depends on pancreatic α-cells. Excessive plasma glucagon levels, along with impaired regulation of α-cell secretion, are involved in the pathophysiology of T2DM. Despite their importance, the effects of aging...

Senescent cells are a key driver of aging and contribute to many age-related diseases. Senolytics, agents that selectively eliminate senescent cells, offer a promising therapeutic strategy to treat age-related diseases but face significant barriers to clinical translation. Fisetin, a natural flavonoid senolytic, has progressed to clinical trials but is limited by suboptimal efficacy and poor bioavailability. To address these challenges, we developed two novel fisetin-derived flavonoid...

CONCLUSIONS: Healthcare access among adults aged 80 years and older is shaped by interacting digital, physical, relational, communicative, organizational, and age-related factors. Access was generally not perceived as completely impossible, but as dependent on timely appointments, digital or telephone support, physical capacity, family assistance, and the ability to navigate healthcare processes. These findings highlight the need for age-sensitive healthcare pathways, including simplified...

Traditionally viewed as a classic sentinel of innate immunity, Toll-like receptor 4 (TLR4) has emerged as a crucial pathological driver within the vascular endothelium, with its identity dictated by cell-type specificity, microenvironmental context, and fluctuating expression levels. This review critically examines the dual functional nature of endothelial TLR4, delineating how it transitions into a primary driver of vascular aging and organ-specific vascular pathologies. The profound spatial,...