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As helium-3 runs scarce, researchers seek new ways to chill quantum computers
Tight supplies of precious isotope are driving new approaches to ultracold tech
An Extracellular Matrix Aging Clock Based on Circulating Matrisome Proteins Predicts Biological Aging and Disease
Plasma proteomic aging clocks estimate biological age and are linked to age-related diseases, but thus far, there has been little focus on circulating extracellular matrix (ECM) proteins, which play a central role in tissue structure and age-related decline. Here, we use publicly available proteomic datasets to profile plasma ECM protein abundances across the human lifespan and reveal a distinct U-shaped trajectory with age. Our ECM-based aging clock, constructed from 14 plasma proteins,...
Endothelial Sirtuins and Mitochondrial Function Are Associated With Testosterone Status: Implications for Accelerated Vascular Aging in Middle-Age and Older Men With Low Testosterone
Middle-aged/older (MA/O) men with low testosterone have greater oxidative stress-mediated vascular endothelial dysfunction, a major risk factor for cardiovascular disease (CVD). Testosterone deficiency impairs mitochondria, a source and target of oxidative stress. Whether the greater vascular endothelial dysfunction in MA/O men with low testosterone is related to mitochondrial dysfunction is unknown. This cross-sectional study measured mitochondrial respiration in peripheral blood mononuclear...
Ghrelin Receptor Deletion or Pharmacological Inhibition Improves Muscle Function in Aging Male Mice
Sarcopenia is characterized by age-related declines in muscle strength and mass, along with impaired physical function. It remains an unmet medical need, and there are no pharmacological interventions approved for this indication. The activation of growth hormone secretagogue receptor (GHSR)-1a, also known as ghrelin receptor, stimulates food intake and has acute anabolic effects. However, its impact on aging muscles remains uncertain. We examined the effects of GHSR-1a deletion on sarcopenia...
‘Science needs defending’: record number of researchers run for office in US mid-terms
Today’s robots walk, swim, fly, and manipulate objects on the go—and they’re just getting started
Science, Volume 392, Issue 6795, April 2026.
Repurposing of a DNA segregation machinery into a cytoskeletal system controlling cell shape
Science, Volume 392, Issue 6795, April 2026.
Gas-depleted planet formation occurred in the four-planet system around the red dwarf LHS 1903
Science, Volume 392, Issue 6795, April 2026.
Sex effects on gene expression across the human cerebral cortex at cell type resolution
Science, Volume 392, Issue 6795, April 2026.
HNF1B integrates signals in a feed-forward loop driving kidney disease progression
Science, Volume 392, Issue 6795, April 2026.
An opposing molecular gradient axis underlies primate cortical organization
Science, Volume 392, Issue 6795, April 2026.
B lymphocyte protein factories produced by hematopoietic stem cell gene editing
Science, Volume 392, Issue 6795, April 2026.
Stem cell control in the lung by an autocrine injury-activated Igf complex
Science, Volume 392, Issue 6795, April 2026.