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Could the monocyte-to-high-density lipoprotein cholesterol ratio serve as a reliable marker for orthostatic hypotension in older adults? A cross-sectional study
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Spatiotemporal Transcriptomics Characterizes Immune Microenvironment During Mouse Liver Aging
The liver is a major metabolic organ, responsible for synthesizing and breaking down diverse metabolites. Recently, the liver's immunological functions have gradually been unveiled: combating pathogens and maintaining tissue homeostasis. Age-related functional alterations in these immune cells emerge as potential drivers of hepatic dysfunction and age-associated pathologies. However, systematic investigations into spatiotemporal immune cell dynamics during liver aging remain limited. To address...
Telomere Dysfunction and Proteostasis Decline Define Distinct Pathways of Cellular Senescence in the Human Respiratory Tract
As the global population ages, cellular senescence contributes increasingly to the burden of age-related diseases. Hallmarks of this process include telomere shortening and loss of proteostasis, frequently linked to DNA damage-associated transcriptional stress. Although telomere dysfunction-induced foci (TIF) have been well documented in lungs from patients with idiopathic pulmonary fibrosis (IPF), their occurrence and role during physiological lung aging remain unclear. Analysis of senescence...
UNC45B Reduction With Aging: A Myofiber-Intrinsic Promoting Factor for Sarcopenia
Skeletal muscle mass and force decline with age, and the loss of muscle force precedes muscle atrophy. However, the underlying mechanisms remain unclear. Here, we investigated the role of the myosin co-chaperone, uncoordinated mutant number-45 myosin chaperone B (UNC45B), in regulating muscle mass and force. UNC45B expression decreased in mouse gastrocnemius muscle with age, particularly at 24 months old, and adeno-associated virus vector-mediated knockdown of Unc45b in 3-month-old mouse triceps...
Forty years after Chernobyl, more nuclear disasters are inevitable — plan for them
Personalized CRISPR therapies could soon reach thousands — here’s how
AI doom warnings are getting louder. Are they realistic?
Yellow glass shows insect wings at their best
This simple house may help prevent multiple fatal diseases in African children
Randomized, controlled trial shows the $8800 design can reduce cases of malaria, diarrhea, and respiratory infection
Watch a spider’s heart race when traffic gets too loud
Study captures a hidden stress response in roadside orb weavers
Cocaine pollution gives salmon wanderlust
First study of how drugs affect behavior of fish in the wild adds to concerns about chemical exposure
This disabled parrot has become king by learning to ‘joust’
Despite missing his entire upper beak, Bruce the kea is winning at life
The temperature dependence of amyloid <em>β</em> solubility reveals the hydrophobic effect as the main driving force for fibril formation
The aggregation of amyloid proteins into fibrillar and oligomeric aggregates is linked to a number of neurodegenerative diseases. While the disease onset remains elusive in many cases, an understanding of the driving forces for the aggregation may help finding possible causes. While effects on amyloid formation kinetics are more commonly studied, gaining insights into these driving forces require a thermodynamic approach with equilibrium measurements. Here we investigate the temperature...
Dopaminergic modulation of the sense of agency influences moral behavior in Parkinson's disease
Embodied accounts of morality propose that corporeal self-awareness helps restrain immoral actions. The Sense of Agency (SoA)-the feeling of controlling one's actions and their consequences-drops when individuals harm others. However, whether modulating SoA shifts moral behavior remains unclear. Parkinson's Disease (PD) offers a unique model to address this question, because dopaminergic dysfunction affects both SoA and moral decision-making. We tested 23 individuals with PD in ON and OFF...
Effect of alendronate on survival and bone properties in Nothobranchius furzeri: insights from a model of accelerated aging
Alendronate effectively inhibits osteoclastic bone resorption and is considered as first line treatment of osteoporosis. Additionally, several studies suggest a beneficial effect on mortality that goes beyond life-extending effects attributed to the well-established fracture risk reduction. However, mechanisms of the mortality reducing effect of bisphosphonates are unclear. The turquoise killifish Nothobranchius furzeri (N. furzeri), a well-known model of accelerated aging, exhibits an extremely...
The Role and Mechanisms of Methylation Modifications in the Development and Progression of Hypertension
Hypertension is a globally prevalent cardiovascular disorder with a multifactorial etiology involving genetic variations, environmental cues, aging and their complex interactions. Despite extensive research, the precise molecular mechanisms by which these factors drive hypertension remain incompletely elucidated. Traditional research has focused on classic pathological pathways, including renin-angiotensin-aldosterone system (RAAS) activation, endothelial dysfunction, oxidative stress, chronic...
Multifaceted Cell Death in Atherosclerosis: Mechanisms, Pathological Impact, and Therapeutic Targeting
Atherosclerosis (AS) is a chronic inflammatory vascular disease associated with aging, the initiation and progression of which is closely related to multiple cell death pathways. This review systematically elucidates the specific activation mechanisms and pathological contributions of ferroptosis, pyroptosis, apoptosis, autophagic cell death, necroptosis, NETosis, cuproptosis, parthanatos, and PANoptosis in vascular endothelial cells (VECs), macrophages, vascular smooth muscle cells (VSMCs), and...
Adipose single cell epigenome and transcriptome localize genetic risk for cardiometabolic disease and accelerated aging
Obesity impairs subcutaneous adipose tissue function, which predisposes to chronic cardiometabolic comorbidities and accelerated biological aging. However, regulatory variants, their target genes and epigenomic landscape underlying this predisposition in each subcutaneous adipose tissue cell-type remain elusive. Our subcutaneous adipose tissue cell-type level cis-expression quantitative trait and colocalization analyses reveal cis-expression quantitative trait locus variants, regulating 279...
Cohort profile Davos Alzheimer's Collaborative DAC Egypt Cohort
The Davos Alzheimer's Collaborative (DAC) Egypt Cohort (DAC-Egypt) is a newly established longitudinal study of cognitive aging in a community-based convenience sample of older Egyptian adults. The cohort's purpose is to characterize trajectories of cognitive decline and dementia risk factors in an understudied population, filling a critical gap in aging research in the Middle East. Participants (n = 1,530) aged 55 and above were recruited via regionally diverse convenience sampling, with...
Microbiome signature of Parkinson's disease in healthy and genetically at-risk individuals
Parkinson's disease (PD) is a major cause of disability. GBA1 variants are the most common genetic risk factor for PD and increase the risk up to 30-fold. Why only approximately 20% of GBA1 variant carriers develop PD remains unknown. Here, by combining clinical and fecal metagenomics data from 271 patients with PD, from 43 carriers of GBA1 variants not manifesting PD symptoms (GBA-NMC) and from 150 healthy controls, and using an innovative microbiome analysis, combining differential abundance...