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The once-obscure Danionella fish takes center stage as a model research organism in a major new project funded by Howard Hughes Medical Institute

CONCLUSIONS: This scoping review charts the models of publicly funded home care across six high-income countries and identifies gaps in the evidence. The findings underscore the need for consistent and comparative evaluation of home care models as population ageing and policy attention to integrated people-centred care intensifies.

Adaptations in subcutaneous adipose tissue (SAT) metabolism may contribute to cardiometabolic health improvements in response to exercise training, especially during aging. Here we investigated the potential effects of long- and short-term exercise on adipogenesis and lipid metabolism in adipose tissue of older women (age 61-80 years). The effects of long-term (> 5 years) physical activity and short-term (4 months) exercise training were evaluated, with a focus on adipocyte size, adipogenic...

CONCLUSIONS: In this matched longitudinal analysis of US adults aged 65 years or older, reported hip fracture marked a more adverse trajectory of cognitive aging. Cognitive vulnerability was evident before the fracture-report index, cognition was lower by the index interview, and additional post-index divergence was most apparent for global cognition and mental status.

Oxidative stress drives tumor microenvironment (TME) remodeling by inducing metabolic reprogramming and cellular senescence. Glutamine, a key substrate supporting oxidative stress defense, has been implicated in TME remodeling and metastasis, yet its specific role in initiating tumor invasion remains unclear. Here, oxidative stress induced the generation of senescent macrophages in the TME, and clinical samples showed that their accumulation positively correlates with malignancy. We established...

Arterial aging is a major risk factor for cardiovascular disease and is associated with progressive changes in vascular structure and function, including arterial stiffening, reduced elasticity, extracellular matrix remodeling, chronic low-grade inflammation, and accumulation of senescence-associated cell states. Recent advances in single-cell RNA sequencing (scRNA-seq) have provided new opportunities to resolve the cellular heterogeneity underlying these age-related alterations in the arterial...

Aging induces immunosenescence, a progressive decline in immune function underpinning age-related pathogen vulnerability, yet T/B cell receptor (TCR/BCR) repertoire remodeling during aging remains incompletely characterized, especially in non-European populations. Additionally, SARS-CoV-2 may perturb immune homeostasis and accelerate aging, but its impact on immune repertoire aging is unclear. Here, we analyzed leukocyte DNA from 195 healthy Chinese individuals (25-93 years) and 94 post-COVID-19...

Age-related hearing loss and balance decline are prevalent features of organismal aging, yet how the cochlea and vestibular organs converge on shared cellular liabilities remains insufficiently resolved. In particular, whether mitochondrial ultrastructural injury and mitochondrial quality-control programs co-vary with synaptic vulnerability and sensory functional decline across these systems within an age-resolved framework has not been clearly delineated. Here, we compared cochlear and...

Cardiomyocyte senescence drives cardiovascular disease, underscoring the need to define its molecular mechanisms. The role of cystic fibrosis transmembrane conductance regulator (CFTR) ion channel in this process remains unclear, particularly regarding its expression and function. Atrial tissues were collected from patients with sinus rhythm or atrial fibrillation (AF) of varying durations. CFTR was downregulated in AF patients and negatively correlated with p16, p21, and p53. Myocardial aging...

Metabolic dysfunction-associated steatotic liver disease (MASLD) is primarily driven by a Western-style diet and exacerbated with aging, yet underlying mechanisms remain unclear. Given the essential role of thyroid hormone (TH) in MASLD progression, we hypothesized that impaired intrahepatic TH action during aging promotes MASLD progression and severity of MASH with fibrosis. We evaluated hepatic TH metabolism in young (18-24 weeks) and old (108-120 weeks) C57BL/6J mice fed either a normal chow...

CONCLUSIONS: Polypharmacy and multimorbidity represent substantial gross population-level burdens in rural Thai older adults. These findings apply specifically to older adults accessing outpatient services at secondary hospitals in the 8th Health Service Region and should not be generalized to the entire rural older adult population. High prevalence of potentially inappropriate medications indicates urgent need for medication optimization interventions. Diabetes emerges as the leading disease...

This correspondence offers a methodological reflection on the cross-sectional study by Darabi and colleagues, which examines loneliness and social support in older Iranian adults with cardiovascular disease. The study addresses an important gap in Middle Eastern aging research. However, the reported positive correlation between loneliness and social support invites closer methodological consideration. We invite readers to consider four methodological aspects: whether shared method variance may...