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Relationships between support provision, social cohesion and belonging, and well-being among community-dwelling older people: a longitudinal survey study

6 hours 53 minutes ago
CONCLUSIONS: Our study offers a new understanding of how the community environment may influence older people's support behaviors. Findings suggest that social cohesion and social belonging play distinct roles in relation to support provision among older people. Practices aimed at facilitating mutual support and well-being may need to take specific roles of different dimensions of community environment into account.
Wenran Xia

Interplay of the ENS and Microbiota With Murine Gut Epithelium-Derived Organoids in Aging

6 hours 53 minutes ago
The intestine is one of the first organs to show signs of aging, including cellular changes, microbiota shifts, and reduced regenerative capacity. The different components of the gut-such as the epithelium (which is directly exposed to a diverse array of host-microbe interactions), the microbiota itself, and the underlying enteric nervous system-likely contribute to aging in distinct ways. Understanding their individual and interactive roles is key to elucidating the mechanisms of intestinal...
Tinh Thi Nguyen

Addressing Sexuality With Older People in Primary Care and Hospitals: A Systematic Review of Professional Perceptions and Experiences

6 hours 53 minutes ago
Sexuality in older age remains a taboo subject. Little is known about the perceptions and experiences of healthcare professionals when addressing this topic with older adults. This systematic review, registered in PROSPERO, aims to understand the perceptions, practices, and recommendations of healthcare professionals in primary and hospital care regarding the approach to sexuality and sexual health in older people. The 17 selected studies, conducted in six countries, show that physicians and...
Ana Carolina Frias

Old muscle stem cells can act young again but there’s a catch

7 hours 52 minutes ago
Scientists at UCLA discovered a surprising reason aging muscles heal more slowly. In older muscle stem cells, a protein called NDRG1 builds up and acts like a brake, slowing the cells’ ability to jump into repair mode after injury. But there’s a twist: that same protein helps the cells survive the stresses of aging, allowing them to stick around longer.

The real cause of a common stroke may have been missed for decades

8 hours 10 minutes ago
Scientists have discovered that a common type of stroke may have a very different cause than doctors once thought. Instead of fatty plaque clogging arteries, the strongest link was found with enlarged and damaged blood vessels deep within the brain. The finding helps explain why standard treatments like aspirin are often less effective and is driving the search for new therapies that target the brain’s tiny blood vessels directly.

This spray-on powder can stop life-threatening bleeding in 1 second

20 hours 51 minutes ago
A new spray-on powder developed by KAIST can stop life-threatening bleeding in about one second by instantly forming a strong gel over a wound. It works on deep and irregular injuries where conventional hemostatic products often struggle and remains effective even after years of storage in harsh conditions. Originally created for the battlefield, the technology could also transform emergency care in disasters, ambulances, and hospitals.

VPS13C/PARK23 initiates lipid transfer and membrane remodeling for efficient lysosomal repair

1 day 6 hours ago
Perturbations in lysosome integrity are tightly linked to neurological disorders and ageing, but the underlying pathogenic mechanisms are incompletely understood. Using an unbiased proteomic approach, we here identified the bridge-like lipid transport protein VPS13C/PARK23 as a key component of a global early response pathway to lysosome damage. VPS13C readily binds lysosomes under mechanical or osmotic tension in anticipation of membrane lesions. The latter trigger a conformational change in...
Oluwatobi Andrew Adeosun

Expanding Home- and Community-Based Service Access in the Veterans Health Administration

1 day 6 hours ago
CONCLUSIONS AND IMPLICATIONS: Although HCBS availability varies across sites and regions, veterans' access also depends on VA staff time to conduct outreach, foster collaborations, and coordinate HCBS with internal and external partners. Understanding and disseminating effective strategies to strengthen veterans' HCBS access is vital as the need for HCBS continues to grow nationally.
Heather Davila

Brain structure in the cingulate cortex and locus coeruleus in late life is associated with engagement in complex mental activities across the life span

1 day 6 hours ago
There is great interest in characterizing the activities or lifestyle factors that are important for successful aging; nevertheless, rigorous investigations using multimodal neuroimaging measures in conjunction with validated measures of activities are underrepresented in the literature. To address this gap, we assessed whether engagement in complex mental activities across early, middle, and late life, is associated with metrics of brain health in a sample of cognitively unimpaired older adults...
Jennifer L Crawford

Hippocampal-cortical structural networks in the progression of cognitive impairment: A source-based morphometry analysis in individuals with subjective cognitive decline, mild cognitive impairment and Alzheimer's disease

1 day 6 hours ago
Neural plasticity and memory mechanisms progressively change during pathological aging. This study aimed to identify patterns of structural covariance across Alzheimer's disease (AD) stages and their relationship with episodic memory performance. Fifty-nine AD patients, 59 patients with amnestic Mild Cognitive Impairment (a-MCI), 46 individuals with Subjective Cognitive Decline (SCD), and 49 Healthy Controls (HC) underwent neuropsychological assessment, including verbal episodic memory tests...
Laura Serra

Psychological stress drives aging-like hematopoietic stem cell dysfunction through a brain-gut-bone marrow axis

1 day 6 hours ago
Chronic stress influences hematopoietic stem cells (HSCs). However, how psychological stress regulates HSC function remains incompletely understood. Here, we show that psychological stress impairs HSC self-renewal and lymphoid differentiation, inducing aging-like phenotypes. Stress suppresses neuronal activity in the medial prefrontal cortex (mPFC) and periaqueductal gray (PAG), leading to HSC dysfunction, whereas chemogenetic activation of these regions restores HSC function. Psychological...
Xiaobin Tian