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Dietary unsaturated fatty acids distinctly associate with the early age sleep-wake cycle and gut integrity in aged fruit flies, Drosophila melanogaster

1 day 4 hours ago
Obesity is a risk factor for compromised health and a driver for non-communicable diseases. Effects of various fats on health, behavior, and other parameters have been studied using different model organisms, including fruit flies Drosophila melanogaster, by exposing them to dietary fats (saturated and trans fatty acids). However, the long-term and short-term effects of dietary unsaturated fatty acids (USFA) on physiology and sleep-activity behavior are relatively less explored. Hence, the...
Aradhana Joshi

Mucuna pruriens mitigates aging-related testicular dysfunction and sperm parameters by restoring cell adhesion molecules and junctional complexes

1 day 4 hours ago
Aging is associated with progressive testicular dysfunction, including disruption of the blood-testis barrier (BTB), loss of junctional proteins, impaired spermatogenesis, and reduced fertility. This study examined the therapeutic effects of Mucuna pruriens (M. pruriens), a leguminous plant with potent antioxidant and anti-inflammatory properties, on age-related degeneration of testicular junctional molecules in male Wistar albino rats. Adult (4-5 months) and aged (20-22 months) rats were...
Mohammad Zafar Iqbal Khan

p21(+)TREM2(+) senescent macrophages fuel inflammaging and metabolic dysfunction-associated steatotic liver disease

1 day 4 hours ago
Cellular senescence drives chronic sterile inflammation during aging via the senescence-associated secretory phenotype, yet the senescent cell types responsible are poorly defined. Macrophages share multiple features of senescence, including inflammatory secretion, yet whether macrophages can adopt a senescent state remains unclear. Here we identify p21⁺Trem2⁺ senescent macrophages as a major source of inflammaging, using primary mouse and human macrophage models of DNA damage and...
Ivan A Salladay-Perez

Longitudinal multimorbidity trajectories shape personalized glycaemic patterns

1 day 4 hours ago
Older individuals often live with diverse combinations of chronic diseases. However, whether multimorbidity contributes to glycaemic dysregulation remains unclear. Here we show that cumulative disease trajectories shape interindividual glycaemic variability throughout the ageing process. Tracking 1,398 participants in the Guangzhou Nutrition and Health Study cohort over 12 years, we develop a systemic multimorbidity index (MMI-system) that reflects the cumulative burden of chronic disorders. We...
Ke Zhang

An Extracellular Matrix Aging Clock Based on Circulating Matrisome Proteins Predicts Biological Aging and Disease

1 day 4 hours ago
Plasma proteomic aging clocks estimate biological age and are linked to age-related diseases, but thus far, there has been little focus on circulating extracellular matrix (ECM) proteins, which play a central role in tissue structure and age-related decline. Here, we use publicly available proteomic datasets to profile plasma ECM protein abundances across the human lifespan and reveal a distinct U-shaped trajectory with age. Our ECM-based aging clock, constructed from 14 plasma proteins,...
Loet Coenen

Endothelial Sirtuins and Mitochondrial Function Are Associated With Testosterone Status: Implications for Accelerated Vascular Aging in Middle-Age and Older Men With Low Testosterone

1 day 4 hours ago
Middle-aged/older (MA/O) men with low testosterone have greater oxidative stress-mediated vascular endothelial dysfunction, a major risk factor for cardiovascular disease (CVD). Testosterone deficiency impairs mitochondria, a source and target of oxidative stress. Whether the greater vascular endothelial dysfunction in MA/O men with low testosterone is related to mitochondrial dysfunction is unknown. This cross-sectional study measured mitochondrial respiration in peripheral blood mononuclear...
Branden L Nguyen

Ghrelin Receptor Deletion or Pharmacological Inhibition Improves Muscle Function in Aging Male Mice

1 day 4 hours ago
Sarcopenia is characterized by age-related declines in muscle strength and mass, along with impaired physical function. It remains an unmet medical need, and there are no pharmacological interventions approved for this indication. The activation of growth hormone secretagogue receptor (GHSR)-1a, also known as ghrelin receptor, stimulates food intake and has acute anabolic effects. However, its impact on aging muscles remains uncertain. We examined the effects of GHSR-1a deletion on sarcopenia...
Haiming L Kerr