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Sex-Specific Regulation of the Turandot Gene Family Modulates Temperature-Dependent Lifespan in Drosophila melanogaster

8 hours 34 minutes ago
Ambient temperature is a primordial determinant of longevity across the animal kingdom, yet the molecular transducers that couple thermal cues to aging rates remain elusive. Here, we interrogate the transcriptomic and metabolomic landscapes of Drosophila melanogaster to decode the mechanisms of temperature-dependent lifespan extension. We find that thermal stress drives a profound remodeling of the transcriptome that surprisingly outpaces metabolic adaptation. Through this multi-omics...
Jessica M Hoffman

This tomato-soy juice reduced inflammation in just four weeks

12 hours 40 minutes ago
A specially formulated tomato-soy juice packed with natural plant compounds may help calm inflammation linked to obesity, according to a new clinical study. Healthy adults with obesity who drank the juice daily for four weeks saw significant reductions in several key inflammatory proteins in their blood, while a control tomato juice did not produce the same effect.

Caffeine reversed memory problems caused by sleep deprivation

13 hours 7 minutes ago
Scientists discovered that sleep deprivation damages a key brain circuit responsible for social memory, making it harder to recognize familiar individuals. In laboratory studies, caffeine restored communication between neurons in this pathway and reversed the memory deficits caused by lost sleep. The effect was remarkably targeted, helping the impaired circuit recover without overstimulating normal brain function.

Protein traffic jams may explain aging, memory loss, and Alzheimer’s

1 day 4 hours ago
Scientists at Stanford may have uncovered a hidden reason our brains decline with age. Studying the ultra-short-lived turquoise killifish, researchers discovered that the cellular machinery responsible for building proteins begins to jam and malfunction over time. Tiny structures called ribosomes start colliding and stalling while reading genetic instructions, triggering a chain reaction that leads to faulty proteins and harmful clumps linked to diseases like Alzheimer’s.

Physiological brain clearance architecture revealed by neuronal protein tracing

1 day 8 hours ago
The brain must efficiently clear protein waste to maintain homeostasis, yet physiological drainage pathways remain poorly defined. Standard tracer injection approaches may not reflect endogenous efflux. Here, we develop a non-invasive genetic system to trace neuron-derived protein clearance from the brain to cerebrospinal fluid (CSF) and border tissues. We identify distinct drainage routes and border hotspots missed by tracer injection, confirmed by bioorthogonal labeling of endogenous neuronal...
Yuichi Chayama

Non-decameric NLRP3 reveals a TGN/MTOC-distal pathway of inflammasome activation

1 day 8 hours ago
The NLRP3 inflammasome contributes to a wide range of conditions from infections to Alzheimer's disease. NLRP3 forms an inactive decameric cage, that upon interaction with the trans-Golgi network (TGN) and microtubule organization center (MTOC), leads to inflammasome activation, yet whether non-decamer NLRP3 species form functional inflammasomes remains unclear. Here, we design a NLRP3 exon 3 deletion variant that forms low molecular weight NLRP3 assemblies. Spatially and dynamically highly...
María Mateo-Tórtola

Neuroproteasomes regulate endogenous tau paired helical filament formation in an APOE genotype- and age-dependent manner

1 day 8 hours ago
In Alzheimer's disease (AD), endogenous tau undergoes a pathogenic transition to form paired helical filaments (PHFs), but the cellular mechanisms driving this process have been elusive. Here, we identify the neuron-specific plasma membrane proteasome ('neuroproteasome') as a critical determinant of tau proteostasis. Selective inhibition of neuroproteasome function rapidly triggers the de novo formation of endogenous, sarkosyl-insoluble tau PHFs in primary neurons and mouse brain, which share...
Victoria Paradise

H<sub>2</sub>O<sub>2</sub> sulfenylates GRF8 to facilitate jasmonate signaling by relieving MYC2 inhibition in Arabidopsis

1 day 8 hours ago
H(2)O(2) functions as a signaling molecule regulating plant growth, development, and stress responses; however, its role in jasmonic acid (JA) signaling transduction and JA-regulated biological processes remains elusive. Here, we report that General regulatory factor 8 (GRF8) is a critical factor inhibiting JA signaling, while H(2)O(2) removes this inhibition to facilitate the JA response during root growth and leaf senescence in Arabidopsis. GRF8 interacts with and inhibits MYC2, the key...
Ru-Feng Song

Mitochondria-lysosome coupling contributes to lysosome acidification and aging

1 day 8 hours ago
Nearly all cellular processes are pH dependent. The acidic pH inside the lysosome (vacuole in yeast) is essential for cellular content degradation, signaling, and autophagy. Defects in lysosome/vacuole acidification are a conserved hallmark of aging and age-related diseases. Traditionally, the lysosome/vacuole is thought to import free protons (H⁺) from the surrounding neutral cytosol. Here, we uncovered a conserved lysosome/vacuole acidification mechanism from yeast to human involving...
Qingqing Liu

Spatial transcriptomics and multi-omics approach to decipher age-related tissue microenvironments and therapeutics in neurodegeneration and aging

1 day 8 hours ago
Conventional bulk transcriptomic approaches obscure cellular and tissue-level heterogeneity critical to understanding age-related neurodegeneration. While single-cell transcriptomics resolved cellular identity, it sacrificed spatial context - a fundamental limitation for mechanistic disease understanding. Spatial transcriptomics emerges as a transformative technology that preserves native tissue architecture while enabling genome-wide transcriptome profiling at subcellular resolution,...
Apurva Lakra

Aging in orbit: the twelve hallmarks as a bidirectional bridge between spaceflight-induced senescence and terrestrial geroscience

1 day 8 hours ago
Human spaceflight exposes crew members to a combination of environmental stressors - including microgravity, galactic cosmic radiation, circadian disruption, and prolonged confinement - that together induce multisystem physiological changes resembling terrestrial aging. In this narrative review, we examine how short- and medium-term spaceflight affects all twelve recognized hallmarks of aging. Integrated multi-omics analyses in astronauts and rodent models identified mitochondrial dysfunction as...
Piercarlo Minoretti

Beyond Binary Senescence: Intermediate Cellular States, Tissue Distribution, and Therapeutic Implications in Ageing

1 day 8 hours ago
Ageing is closely linked to cellular senescence, but this relationship remains incompletely defined. Although many studies have reported age-associated increases in senescence markers, no review has systematically integrated the available quantitative data across tissues and species to clarify how senescence-associated cell populations change with age. In addition, the field has often used inconsistent definitions for intermediate and senescent states, making cross-study interpretation...
Soon Sang Park

Effects of sub-chronic cannabis smoke exposure on inflammatory markers in serum and brain in younger and older mice

1 day 8 hours ago
Aging is associated with chronic low-grade inflammation, which is thought to contribute to both cognitive decline and various neurodegenerative diseases. Cannabinoids are reported to reduce levels of inflammatory markers; however, these effects have not been thoroughly assessed in older subjects. To address this gap, we evaluated the effects of sub-chronic cannabis smoke exposure on serum and brain inflammatory markers in younger and older mice. Younger (4 month old) and older (22 month old)...
Emely A Gazarov

Histone modification dynamics in brain aging: unlocking therapeutic potential

1 day 8 hours ago
During aging, the progressive decline in neuronal function contributes to cognitive impairment and predisposes individuals to neurodegenerative disorders. This phenomenon has become increasingly prominent in modern society. Recent studies have found that post-translational modifications (PTMs) of proteins play a crucial role in the aging process, influencing the physiological functions and pathological changes in brain cells. This article reviews the variety and complexity of PTMs across brain...
Bohao Chang

High-quality NiO<sub>x</sub> nanoparticles synthesized via low temperature chemical precipitation method for high-performance inverted perovskite photovoltaics

1 day 8 hours ago
Dual hole transport layers consisting of NiO(x) and self-assembled molecules are widely adopted in inverted perovskite solar cells, yet plagued by high impurity content, inefficient hole transport, low molecular coverage, weak interfacial binding, unstable buried interface and energy level mismatch. Herein, a low-temperature chemical precipitation strategy is developed to synthesize high-quality NiO(x) nanoparticles as hole transport layers. Compared with the room-temperature route, the...
Ziyuan Liu