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Millions take calcium and vitamin D for stronger bones. A major review finds little benefit
For years, calcium and vitamin D supplements have been promoted as a simple way for older adults to protect their bones and prevent falls. But a massive review of nearly 154,000 people found that calcium, vitamin D, or a combination of both provided little to no meaningful protection against fractures or falls for most older adults.
This popular brain supplement was linked to shorter lifespans in men
A large-scale study suggests that men with higher levels of the amino acid tyrosine may have shorter lifespans, potentially losing close to a year of life expectancy. The finding is especially intriguing because tyrosine is commonly associated with brain health and is often used in supplements aimed at boosting focus and performance.
The Convergence of Down Syndrome and Alzheimer's Disease - Scientific and Ethical Imperatives
No abstract
The Aging Microenvironment Shapes Angiogenic Remodeling in IBD-Associated Colorectal Carcinogenesis
Chronic intestinal inflammation establishes a pro-senescent microenvironment that fuels the stepwise evolution from inflammatory bowel disease (IBD) to colorectal cancer. Although cellular senescence initially functions as a tumor-suppressive barrier, the persistent accumulation of senescent cells can promote disease progression through the senescence-associated secretory phenotype (SASP). Key SASP mediators, including VEGF, IL-8/CXCL8, and matrix metalloproteinases (MMPs), reprogram endothelial...
Intracerebroventricular infusion of exercise donor plasma exosomes induces molecular changes indicating exercise-like adaptations in basal ganglia cells of older male rats
Chronic moderate aerobic exercise promotes health in older adults and provides neuroprotection to patients with neurodegenerative diseases, most notably Parkinson's disease (PD). Exosomes are small extracellular vesicles that facilitate interorgan communication. During exercise, they are selectively packaged with bioactive molecules termed "exerkines" and released into the blood. Exosomes protect their exerkine cargo, including DNA, RNA, and proteins, and facilitate their interorgan transit....
Gerobiotics and neuroprotection: effects on the gut-brain axis in age-related neurodegenerative diseases
As the global population ages, effective strategies to attenuate or prevent neurodegenerative processes are becoming increasingly important. Gerobiotics, an emerging class of probiotic strains and their derived postbiotics, are considered promising geroprotective agents because of their potential to target fundamental mechanisms of aging, modulate the gut-brain axis, and attenuate age-related cognitive and functional decline. This review aims to synthesize existing evidence from preclinical and...
SVIP in plasma: a candidate blood-based biomarker for early detection of amnestic mild cognitive impairment
CONCLUSION: Plasma SVIP demonstrates significantly higher diagnostic accuracy than VCP for the detection of aMCI, suggesting its potential as a candidate blood-based biomarker pending large-scale pathophysiological validation.
Nuclear Enlargement as a Histological Hallmark of Skeletal Muscle Aging, Revealed by Deep Learning-Driven Analysis and Validated in Inflammatory Myopathies
Aging reshapes the architecture of human skeletal muscle, yet objective tissue-level markers that capture this process remain limited. We combined large-scale histology with deep learning to identify reproducible features of muscle aging and to test their biological relevance. We analyzed 974 hematoxylin-eosin whole-slide images from a population resource using a dual-attention convolutional neural network and an independent Mask R-CNN model to quantify nuclear size and density, verified by...
Unlocking the aging brain: mTORC1 as a convergent integrator for neurodegeneration and therapeutic intervention
Aging is the primary risk factor for neurodegenerative diseases, characterized by a progressive decline in cellular homeostasis. Central to this process is the mammalian target of rapamycin complex 1 (mTORC1), a convergent integrator regulator of metabolism that integrates nutrient sensing with cellular growth. While essential for development, chronic mTORC1 hyperactivity, termed mTORopathy, emerges during aging, driving a deleterious cycle of mitochondrial dysfunction, neuroinflammation, and...
New GLP-1 diabetes pill delivers major weight loss and blood sugar control
A new oral GLP-1 medication helped people with type 2 diabetes dramatically improve blood sugar control and lose weight in a major clinical trial. The results suggest that highly effective diabetes treatments may soon become available in a much more convenient pill form.
Scientists turned red lettuce green and something surprising happened
Researchers used genome editing to block the production of red pigments in lettuce, causing other beneficial plant compounds to build up instead. The lettuce continued to grow normally, pointing toward a new way to create crops with customized nutritional profiles.
In the field — and sometimes in the lab — the simplest tool is best
At-home brain implant gives man with motor neuron disease his daily life back
Why people should work together to shape the economy
Sperm quality improves in people taking potent obesity drugs
Nanocrystal-tailored recombination for all-perovskite tandem solar modules
A need for pragmatism in preclinical aging and longevity research
How AI is revealing the secret lives of animals from hummingbirds to pumas
Bones of Iron Age skeleton were whittled into tools
The secret behind smoother, better-tasting protein shakes
A new whey protein manufacturing technique could make protein shakes taste better and feel smoother in the mouth. Researchers traced unwanted bitterness to concentrated minerals and found a way to remove them without sacrificing the improved texture.