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Parkinson's disease (PD) is marked by progressive dopamine neuron degeneration, but the phagocytic receptors and cells that clear neuronal corpses remain ill-defined. Moreover, while other cell types like glia, epithelia, and muscle are also impacted in PD, their roles in disease progression are unclear. We report that multiple nonneuronal cell types modulate dopamine neurodegeneration in Caenorhabditis elegans. Astrocyte-like CEPsh glia respond to neuronal stress and regulate dopamine...

Parkinson's disease (PD) is a neurodegenerative disorder for which advancing age is the major risk factor. Aging and PD share several features, including chronic neuroinflammation and pathological protein accumulation. This overlap suggests that mechanisms driving the aging process may also contribute to the onset and progression of PD. In this narrative review, we examine mitochondrial dysfunction as a shared feature of aging and PD, focusing on energy production, calcium buffering, apoptosis,...

ObjectivesNeighborhood resources are protective factors for healthy cognitive aging, yet the impact of these resources may vary by urbanicity. We examined urban-rural differences in the association between the availability of neighborhood social services, religious, and civic organizations, and cognitive decline among older Mexican Americans.MethodData from 628 participants (M(Age) = 80) in 2004-2013 Hispanic Established Populations for the Epidemiologic Study of the Elderly were linked to the...

An NIH study found that women with high levels of two common “forever chemicals” had up to 93% higher rates of an aggressive form of breast cancer. The discovery raises concerns about the potential health effects of persistent chemicals found in everyday products.

Science, Ahead of Print.

Science, Ahead of Print.

Science, Ahead of Print.

Science, Ahead of Print.

Science, Ahead of Print.

Scientists have uncovered a surprising way that fructose, a sugar commonly found in sweetened foods and drinks, may help aggressive ovarian cancer spread. Researchers discovered that cancer cells surviving chemotherapy release fructose that weakens the bonds holding neighboring tumor cells together, making it easier for cancer to spread. High dietary fructose levels and cholesterol-lowering statins also produced concerning effects in preclinical experiments.

A surprising new study suggests that walking, jogging, and even traditional weight training may be less effective at stimulating bone formation than high-intensity sports involving explosive movements and sudden changes in direction. Researchers found that activities such as football and handball increased markers of bone formation by up to 46%, potentially revealing a better way to protect bones against aging and osteoporosis.

A new study found that energy drinks and stimulant supplements were linked to disproportionately frequent reports of serious heart problems, including 11 times more reports of cardiac arrest and 4.5 times more reports of heart attacks. Young adults accounted for nearly half of the cardiovascular reports involving these products, raising concerns about their potential risks despite the study being unable to prove causation.

A surprising study of more than 4,500 older adults found that people who were overweight or obese when diagnosed with dementia had a 16% to 27% lower risk of death than those at a normal weight. Researchers suspect that extra energy and muscle reserves may help patients survive the disease's toll on the body, although the reason for the survival advantage remains unclear.

Ancient manuscripts, including the 1,000-year-old York Gospels, have revealed traces of a deadly sheep virus whose history stretches back more than 3,700 years. Scientists discovered that the virus has remained remarkably unchanged for millennia, turning historic parchment into an unexpected record of ancient disease outbreaks.