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Standardized protocol for plasticity assessment in the aging mouse neocortex using choline-chloride perfusion

16 hours ago
Age-related changes in synaptic function are central to the progression of brain pathologies, including neurodegenerative diseases, underscoring the need for experimental approaches that capture neuronal properties across the lifespan. However, obtaining high-quality tissue preparations from aged animals that permit combined structural and functional analyses of individual neurons is challenging due to increased tissue vulnerability. Here, we present a standardized protocol for acute brain slice...
Pia Kruse

Examination of shared gut microbiome signatures in aging and Parkinson's disease

16 hours ago
Parkinson's disease (PD) is a prevalent neurodegenerative disorder that is characterized clinically by a constellation of motoric deficits including resting tremors, bradykinesia, and rigidity. In recent years, there has been increasing interest in the gut-brain axis with several studies examining the relationship between gut microbiome and PD. Although association studies have reported multidimensional microbiome changes in PD, these observed changes may be confounded by various factors,...
Teddy Jia Wei Tng

Pck1 Deficiency Drives Mitochondrial Dysfunction and Cellular Senescence in Adipocytes

16 hours ago
Cellular senescence of white adipose tissues (WAT) represents an early hallmark of aging; however, the involved mechanisms remain incompletely understood. Here, we identified the cytosolic phosphoenolpyruvate carboxykinase (Pck1) as a key regulator of mitochondrial function and inflammaging in WAT. Pck1 expression was downregulated in both gonadal WAT and inguinal WAT during aging, and adipocyte-specific Pck1 deficiency accelerated inflammaging and metabolic disorders. Untargeted metabolomic and...
Yiting Lei

Effects of daily multivitamin-multimineral supplementation on metabolomic profiles: 2-year findings from the COSMOS randomized clinical trial

16 hours ago
Despite widespread use in the USA, little is known about the impact of multivitamin-multimineral (MVM) supplementation on metabolomic profiles and how this may translate to biological aging and long-term risk of age-related chronic diseases. The COcoa Supplement and Multivitamin Outcomes Study (COSMOS) is a 2 × 2 factorial, placebo-controlled, double-blinded, randomized clinical trial testing daily MVM (Centrum Silver®) in US older adults. In 399 participants with metabolomics profiles...
Sidong Li

Autophagy-Independent Function of ATG-18 Is Essential for Gonadal Longevity in Caenorhabditis elegans

16 hours ago
Autophagy, a highly conserved cellular degradation process, plays essential roles in various physiological processes including aging. Though autophagy is required for lifespan extension in multiple longevity paradigms, the tissue-specific roles of autophagy-related genes (atgs) in longevity remain incompletely understood. Here, we investigate the tissue-specific requirements of atgs to promote longevity conferred by germline ablation (called gonadal longevity) using C. elegans. Remarkably, we...
Tatsuya Shioda

Epigenetic remodeling induced by fatty acids: chromatin modifications and cellular senescence during lipid overload

1 day 16 hours ago
Cellular senescence is a stable cell state sustained by specific gene expression programs that are established and maintained through dynamic changes in chromatin organization. Importantly, these programs are highly dependent on the nature of the senescence-inducing stimulus. In recent years, lipid overload has emerged as a relevant metabolic stress capable of inducing senescence across multiple cell types and tissues, particularly in the context of obesity and high-fat diets. Accumulating...
Karla Estephanía Ávila-Galicia

Associations of epigenetic age acceleration with motor impairment: Evidence from the Parkinson's Progression Markers Initiative cohort

1 day 16 hours ago
Motor decline is a hallmark of Parkinson's disease (PD) and biological aging, yet the specific relationship between systemic biological aging and neuromotor function remains under-characterized. This study leveraged longitudinal phenotypic and whole-blood DNA methylation data from the Parkinson's Progression Markers Initiative (PPMI) to evaluate associations between seven epigenetic aging measures, spanning first-generation, second-generation (risk-optimized), rate-based, and next-generation...
Tao Jiang

Reference data and clustering of lifestyle-based dementia risk factor scales among older Canadian adults

1 day 16 hours ago
CONCLUSIONS: This study provides the first Canadian reference data for these lifestyle scales, enabling personalized risk profiling in health promotion. Lifestyle behaviours cluster in ways that highlight the importance of addressing cognitive, social, and mental wellbeing alongside physical activity and brain-healthy eating in older adults.
Danielle D'Amico