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Fish oil supplements successfully delivered omega-3s to the brain, but a two-year study found no meaningful benefits for memory, cognition, or Alzheimer’s-related brain changes. The results challenge the idea that fish oil pills can help prevent Alzheimer’s and shift attention toward overall diet and lifestyle instead.

Scientists have uncovered a surprising clue that may help explain why multiple sclerosis (MS) progresses rapidly in some people but not others. In brain tissue from patients with severe MS, researchers found large numbers of “foamy” immune cells packed with fat droplets after absorbing damaged myelin. These overloaded cells appear to switch from helping repair the brain to fueling ongoing damage and inflammation.

The unconscious brain appears to be far more capable than scientists once believed. Researchers found that patients under general anesthesia could still process language at a sophisticated level, distinguishing nouns, verbs, and adjectives while listening to stories. Even more remarkably, neural activity showed signs of predicting upcoming words before they were heard. The results challenge traditional ideas about consciousness and hint at new possibilities for brain-computer interfaces.

A six-month study of more than 120 adults in their 70s found that high-intensity interval training (HIIT) may offer a key advantage over other forms of exercise: it helped reduce body fat while preserving valuable muscle mass. While moderate and low-intensity workouts also led to some fat loss, only HIIT maintained lean muscle, which becomes increasingly important with age.

Scientists at UCLA have linked long-term exposure to the pesticide chlorpyrifos with a sharply increased risk of Parkinson’s disease. People exposed to the chemical near their homes were more than twice as likely to develop the condition. Laboratory studies showed that chlorpyrifos damages dopamine neurons and interferes with the brain’s ability to remove toxic protein buildup.

Anti-aging pharmacology has transitioned from early exploratory lifespan-extension studies to a hallmark-informed, multi-level framework that integrates mechanistic, preclinical, and translational evidence. Using a bibliometric-guided, strategy-oriented approach, this review maps the explicit anti-aging drug literature from 2005 to 2025, identifies historically influential compounds, and evaluates their translational readiness. The field converges on three partially overlapping intervention...

CONCLUSIONS: The findings from our study indicate that supporting the psychological and spiritual resources of older adults plays an important role in strengthening the successful aging process. Longitudinal studies on successful aging are recommended.

Aging is associated with structural and functional changes of the vocal folds that may result in presbyphonia, often perceived as a weak or shaky voice. However, the quantitative characterization of underlying age-related vocal tremor across the adult lifespan remains limited. This cross-sectional study investigated the characteristics of vocal tremor across the adult lifespan using automated acoustic analysis. A total of 291 native speakers aged 18-94 years were recruited and underwent...

Teens who use cannabis may face a substantially greater risk of developing serious mental health conditions, including psychotic and bipolar disorders, according to a study of more than 463,000 adolescents. Researchers found cannabis use often preceded these diagnoses by nearly two years, strengthening concerns about its long-term effects on developing brains.

Researchers have identified a vitamin B12–based compound that can cross the blood-brain barrier and home in on glioblastoma tumors. In animal studies, the compound accumulated preferentially in tumor tissue and delivered sustained nitric oxide directly to cancer cells. It also worked synergistically with existing glioblastoma treatments, significantly enhancing their tumor-fighting effects.

Aging may trigger the appearance of specialized stem cells that supercharge the body's ability to create new belly fat. The discovery reveals a potential biological driver of middle-age weight gain and a promising target for future anti-obesity treatments.

Hippocampal atrophy across the lifespan is associated with cognitive decline, as is difficulty understanding speech-in-noise. The hippocampus contains subfields with distinct functions, but their involvement in hearing-related differences is unknown. Here, we used HippUnfold, an automated hippocampal unfolding and subfield segmentation method, together with Multiple Factor Analysis (MFA) to examine shared variance across hippocampal structure, hearing-related function, and cognition in younger...

Aging disrupts physiological homeostasis, impairing thermoregulation, metabolism, and water balance, but the underlying neural mechanisms remain unclear. Here, we identify arginine vasopressin (AVP) neurons in the supraoptic nucleus (SON) of the hypothalamus as a critical driver of these changes in male mice. Single-nucleus RNA-sequencing revealed Avp among the most upregulated neuronal transcripts with age. Aged SON^(AVP) neurons displayed enlarged size and heightened excitability, features...

The goal of developing interventions to slow ageing is not only lifespan extension but more importantly to increase healthspan, the period of life spent in active good health. Nutritional interventions have emerged as a potential strategy to maintain health with age. Testing these interventions for effects on human ageing would take several years and require large cohort sizes. We therefore employed C. elegans as a rapidly ageing model organism to investigate the effects of two commercially...

CONCLUSIONS: This study indicates that retaining ≥ 20 teeth, brushing at least once daily, and using dentures are associated with a lower likelihood of anxiety symptoms among the elderly population. Further prospective studies are warranted to confirm these associations.