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Experimental eye drops help blind mice see again
Scientists have created light-activated drugs that helped blind mice perceive light again and restored visually guided behavior without gene therapy, implants, or specialized lighting. Even more intriguingly, two of the most promising compounds worked when administered as eye drops, pointing toward a potentially simple new approach to restoring vision.
A common vape flavoring may disrupt early embryo development
A popular vanilla flavoring in e-cigarettes may interfere with some of the earliest steps of human development. In lab experiments, vanillin caused embryonic stem cells to lose their ability to develop normally and pushed them toward forming only certain types of tissue.
Researchers followed 400,000 kids for 20 years and found a lasting pre-K advantage
A 20-year study of 400,000 students found that children who attended public school pre-K earned better grades and test scores through high school than those in other childcare settings. Better-trained teachers and earlier exposure to structured classrooms may help explain why the advantage lasted so long.
Scientists tested 212 plant-based meat alternatives. Every one contained fungal toxins
Every one of 212 plant-based meat alternatives and drinks tested in the UK contained at least one naturally occurring fungal toxin, though concentrations remained below recommended EU guideline levels. Researchers say the bigger question is whether regularly eating large amounts of these foods could lead to potentially concerning cumulative exposure over time.
What employers are looking for in the age of AI — and four ways to provide it
Heisuke Hironaka obituary: mathematician who smoothed out geometry’s complexities
Mysteries of the deep and AI friendship: Books in brief
Eating more ultra-processed foods may raise prostate cancer risk by 30%
Ultra-processed foods make up a huge share of the American diet, and new research suggests they may carry another serious health risk for men. In a nationally representative study of more than 17,000 U.S. men, those who ate more ultra-processed foods, including soft drinks, packaged snacks, cereals, and processed meats, had roughly 24% to 31% higher risks of prostate cancer after accounting for factors such as age, smoking, race and ethnicity, and poverty status.
NSF’s new plan to fund graduate students to work in industry covers familiar ground
Agency gives university-industry consortium $47 million to reinvent existing internship program
Vitamin C won’t prevent most colds, but it may do one small thing
The belief that huge doses of vitamin C can ward off colds was popularized more than 50 years ago by Nobel Prize winner Linus Pauling. Since then, larger studies have found that vitamin C does not prevent most people from catching a cold, although regularly taking it may make severe symptoms slightly shorter or milder.
Lifelong dietary interventions selectively reverse age-associated circulating microRNA upregulation in a time-dependent manner in female MMTV-TGF-α mice
Breast cancer is among the leading causes of cancer mortality worldwide, with aging as a major risk factor. Caloric restriction (CR) is a well-established non-pharmaceutical intervention that extends healthspan and delays tumorigenesis, yet the systemic molecular mechanisms remain elusive. Both chronic and intermittent CR influence metabolic homeostasis, but their long-term effects on circulating miRNAs in breast cancer predisposition are unclear. Here, we examined how chronic and intermittent...
An in vivo resource of age-regulated C. elegans intestinal secretory-pathway proteins highlights secreted enzymes associated with lifespan regulation
Secreted proteins are essential to modulate homeostasis in the extracellular space and facilitate communication to distal cells or tissues. Yet, the identity and functional importance of extracellular proteins in aging have been understudied. Here we use proximity labeling followed by quantitative proteomics to systematically characterize proteins along the intestinal secretory pathway in C. elegans, focusing on secreted proteins. We identify intestine-secreted proteins that are modulated with...
Beyond wrinkles
Can the skin microbiome shape healthy aging?
Disruption of sphingolipid metabolism promotes tau seeding through endolysosomal membrane rigidification and rupture
Endolysosomal dysfunction is a hallmark of Alzheimer's disease and related tauopathies, yet underlying mechanisms remain poorly understood. This study investigates the role of sphingolipid metabolism in maintaining endolysosomal membrane integrity and its impact on tau aggregation and toxicity in Caenorhabditis elegans and human cell culture models. Fluorescence recovery after photobleaching and C-Laurdan dye imaging revealed that silencing sphingolipid metabolism genes reduced endolysosomal...