Aggregator

Mitochondria and inflammation are tightly linked in aging and Alzheimer's disease (AD), and recent evidence implicates mitochondrial double-stranded RNA (mt-dsRNA) as a potential trigger of inflammation. We examined mt-dsRNA accumulation and dsRNA signaling in brain aging and AD using complementary human brain tissue and in vitro transcriptomic datasets by quantifying mitochondrial transcripts, dsRNA editing, and related gene expression patterns. We found that mt-dsRNA signatures increased after...

CONCLUSION: The results of this study showed that holding group poetry reading sessions can promote meaning in life, especially in the domain of "searching for meaning" among the elderly. But results showed no significant difference between the two groups' Subjective Vitality mean scores after the intervention. Therefore, holding such classes in elderly day care centers or nursing homes are recommended to improve meaningful life in the elderly.

CONCLUSIONS: Adherence in later life reflects how older adults position themselves toward self‑care in the face of vulnerability, changing identities, and real‑world constraints. Clinical practice may benefit from linking recommendations to what matters most to patients, simplifying regimens, strengthening relational support, and addressing structural barriers. Tailoring care to patients' life contexts may foster more sustainable and meaningful engagement with treatment.

CONCLUSIONS: Immune-inflammatory and nutritional status mediate age-dependent survival disparities in older NPC patients. These findings underscore the clinical imperative of addressing inflammatory burden and nutritional depletion in geriatric oncology and advocate for integrated biomarker-guided management strategies.

Mitochondria and inflammation are tightly linked in aging and Alzheimer's disease (AD), and recent evidence implicates mitochondrial double-stranded RNA (mt-dsRNA) as a potential trigger of inflammation. We examined mt-dsRNA accumulation and dsRNA signaling in brain aging and AD using complementary human brain tissue and in vitro transcriptomic datasets by quantifying mitochondrial transcripts, dsRNA editing, and related gene expression patterns. We found that mt-dsRNA signatures increased after...

INTRODUCTION: Precise regulation of grip forces is fundamental for skilled object manipulation and independent navigation of everyday activities throughout the lifespan. Maximal grip strength is a widely used biomarker of aging and frailty, but it provides limited insight into the temporal and inhibitory control mechanisms required for dexterous prehension. Evidence suggests that grip-force release, which requires integration of sensory feedback and inhibition of sustained grip, may be...

Scientists found that a modified Mediterranean-style diet with low protein and just enough methionine helped mice live healthier lives while reducing body fat and frailty. Human data also linked lower animal protein intake to lower rates of obesity and Type 2 diabetes, suggesting the approach could benefit people as well.

A new study debunks the long-standing claim that baby rattlesnakes are more dangerous than adults. Researchers found that young rattlesnakes can control their venom just like adults, while adult snakes usually inject much more venom and cause more serious bites. The team also uncovered how the myth spread through decades of inaccurate news reports and misleading quotes from trusted sources.

Researchers found that mRNA cancer vaccines can recruit an unexpected immune cell to launch powerful tumor-fighting responses, overturning a long-held assumption about how the vaccines work. The discovery could lead to more effective cancer vaccines and help scientists tailor treatments for better patient outcomes.

Human aging is a heterogeneous, multi-system process that spans molecular, tissue, and physiological decline. In this issue of Cell, Li et al. integrate clinical data, multi-omics, and organ-associated signatures to construct a multi-layer framework for quantifying biological aging across scales.

CONCLUSIONS: Irisin represents a promising link between muscle-derived signaling and immune resilience. While clinical application is currently hindered by assay variability and a need for larger human cohorts, its role in modulating both immunosenescence and acute sepsis pathophysiology marks it as a possible prognostic biomarker and a potential therapeutic target in the vulnerable aging population.

BACKGROUND: Chronic low-grade inflammation ("inflammaging") is a key driver of age-related pathologies including cardiovascular disease, neurodegeneration, and metabolic syndrome. Diet plays a dual role in modulating this process, acting both as a source of pro-inflammatory molecular patterns and as a delivery system for geroprotective compounds.

There are extensive ongoing efforts to slow or even reverse human aging, such as with epigenetic cellular reprogramming, thymus rejuvenation or senolytics. In parallel, new and diverse metrics-known as biological clocks-have been discovered and shown to track the pace of aging in an individual and their organs, tissues and cells. These clocks have multiple potential use cases, including identifying people at high risk of disease, serving as a foundation for prevention or early detection, and...

No abstract

Alzheimer's disease (AD) remains the leading cause of dementia worldwide and an escalating global health crisis. The hallmark amyloid plaques and neurofibrillary tangles (NFT) are now known to be accompanied by a complex array of pathologies that culminate in neurodegeneration and cognitive decline. New disease-modifying therapies for AD can now slow cognitive decline through the removal of amyloid plaques from the brain, but treatments to stop or prevent cognitive impairment remain elusive. In...

Parkinson's disease (PD) is characterized by progressive loss of nigral dopaminergic neurons, resulting in disabling motor symptoms. Intracerebral transplantation of stem cell-derived dopaminergic progenitors to replace lost endogenous dopaminergic neurons offers a new potentially restorative therapeutic approach for PD. Here we report the 12-month primary safety end point and interim efficacy outcomes from a phase 1/2, open-label, multicenter trial evaluating STEM-PD, a cryopreserved,...

While spatial multiomics offers insights into complex biological systems, its widespread adoption is hindered by technical challenges, specialized requirements and limited accessibility. Here we present NicheTrans, a spatially aware cross-omics translation method and a flexible Transformer-based multimodal framework. Unlike existing single-cell translation methods, NicheTrans incorporates both cellular microenvironment information and multimodal data. We validated the advantage of NicheTrans...

Complement component 1q (C1q), the initiator of the classical complement cascade, mediates synaptic elimination in development and disease, yet the triggers for its deposition on synapses remain unclear. Using in vivo chemogenetics, we demonstrate that neuronal hyperactivity induces region-specific, C1q-dependent synapse loss in the adult hippocampus. Suppressing perforant pathway hyperactivity in a mouse model of Alzheimer's disease reduced local amyloid-β amounts and C1q deposition and...