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Approach could provide scientists with a quicker, gentler way to gauge the health of bird populations

Representative Zoe Lofgren prepares to lead the House science committee that microbiologist Jasmine Clark hopes to serve on

Multiple object tracking (MOT) is a core function of dynamic visual attention that relies on the ability to simultaneously monitor several moving objects. Although MOT performance is known to decline with age, and to depend on efficient oculomotor strategies, how these processes interact across the adult lifespan and under degraded visual input remains poorly understood. Here, we examined age-related differences in MOT under normal and gaze-contingent viewing conditions simulating central and...

We characterize the spatiotemporal dynamics of the tumor microenvironment (TME) in bladder cancer (BLCA) samples before and after neoadjuvant immunotherapy in a multicenter real-world cohort (n = 606). We identify two distinct differentiation outcomes in BLCA epithelial cells: sensitivity and resistance to immunotherapy. Additionally, we identify SERPINH1 as a common target of acquired immunotherapy resistance in BLCA. Furthermore, we characterize an immunotherapy-induced tumor-myeloid barrier,...

T cell senescence is an important dysfunctional state associated with tumor progression, but whether senescent T (Tsen) cells directly reprogram tumor cell behavior remains unknown. Here, single-cell transcriptomic analyses identify abundant Tsen cells across breast, colorectal, and lung cancers. Tsen cells actively promote tumor growth, metastasis, stemness, and chemotherapy resistance by reprogramming tumor cells in vitro and in vivo. Mechanistically, lipid-enriched senescence-associated...

Sarcopenia is characterized by progressive loss of skeletal muscle strength, mass, and function during aging, driven by impaired proteostasis, mitochondrial dysfunction, altered metabolism, regenerative failure, and neuromuscular decline. Experimental models are needed to determine how these processes drive muscle degeneration and identify testable therapeutic mechanisms. Zebrafish combine whole-animal physiology with genetic manipulation, live imaging, and scalable phenotypic analysis, making...

Osteoporosis is a highly prevalent age-related disorder, and accumulating evidence suggests that it does not arise in isolation but is intrinsically linked to the aging process. Here, we employed integrative methods to systematically identify the relationship between aging and osteoporosis, and uncover the critical cell types and molecular regulators that mediate this association. Observational analysis of phenotypic data from UK Biobank and Mendelian Randomization analysis of summary-level...

Aging is accompanied by alterations in inflammatory signaling, regulated cell-death pathways, and cellular stress responses in the brain. This study investigated the effects of propolis and dexpanthenol, administered individually or in combination, on gasdermin-related, inflammatory, and heat-shock gene expression in naturally aged male mice. Thirty-five male CD-1 mice were randomly allocated to five groups (n = 7/group): Young Control, Aged Control, Aged + Propolis, Aged + Dexpanthenol, and...

Cellular senescence and its associated secretory phenotype (SASP) represent a fundamental mechanism of biological aging. SASP-related inflammation has been implicated in cardiovascular disease. However, its role in perioperative risk in cardiac surgery remains largely unexplored, and established risk scores such as EuroSCORE II and the STS Score do not regard biological aging or senescence. In this prospective single-center cohort study, 131 patients aged ≥ 65 years undergoing elective cardiac...

Biological aging is complex and resists any single mechanistic narrative. This article develops a conceptual framework for aging biology through a series of brief statements on central topics in the field, with the goal of discussing aging simply, directly and accessibly. The organizing principle is that aging is a default outcome of living: because biological processes are inherently imperfect, deleterious changes (the deleteriome) accumulate over time and progressively erode functional...

Nicotinamide Adenine Dinucleotide (NAD) is a critical cellular coenzyme whose decline associates with various chronic and inflammatory diseases. Improved NAD restoration may reduce disease risks and extend healthy lifespan. We report here that certain commensal bacteria including specific probiotic species produce (amide-)N-methylnicotinamide (N-MNA), which is a structural isomer of methylnicotinamide, a nicotinamide degradative metabolite. Patients with gut dysbiosis and inflammation show...

Aging is a major risk factor for melanoma. However, it is unclear whether aging fuels tumor evolution by altering mutation rates, changing the microenvironmentally induced selection on drivers, or both. We analyzed 5472 melanomas, estimating how selection on individual variants changes with patient age while accounting for differing neutral mutation rates. Neutral mutation rates increased only modestly with age; ultraviolet damage remained predominant, but endogenous processes increasingly...

mTORC1 activity is increased in muscle with aging and is implicated as a potential driver of age-related declines in muscle health. While pharmacological inhibition of mTORC1 improves lifespan and healthspan, it remains unclear whether chronic activation of mTORC1 is sufficient to accelerate aging in skeletal muscle. We aimed to address this question using an inducible model of muscle-specific knockout of Depdc5, which encodes the protein DEP domain containing 5 (DEPDC5), a negative regulator of...

A coordinated response to stress is crucial for promoting the short- and long-term health of an organism. The perception of stress, frequently through the nervous system, can lead to physiological changes that are fundamental to maintaining homeostasis. Activating the response to low oxygen, or hypoxia, extends healthspan and lifespan in Caenorhabditis elegans. However, despite some positive impacts, negative effects of the hypoxic response in specific tissues prevent translation of their...

ObjectivesThis study explores the relationship between marital status, living arrangements, and aging well among Chinese adults aged 50 and older.MethodsUsing data from the China Family Panel Studies (CFPS), we developed a multidimensional measure of aging well (physiological, functional, cognitive, psychological, and subjective). Analysis was based on a five-category typology of marital and living arrangements.ResultsA clear hierarchy emerged in the findings: married individuals co-residing...

A study of nearly 5,800 adults found that heart scans measuring calcium buildup in the arteries led to the same observed rate of major cardiovascular events as traditional risk assessments, despite recommending statins to far fewer patients. Surprisingly, patients advised to take statins based on their scans were nearly three times as likely to stick with their medication, raising intriguing questions about how doctors should identify and treat heart disease risk.