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Laser-written patterns on glass could store data for millennia at a time

CONCLUSION: These findings support a relationship between declines in uneven terrain mobility and n-back cognitive function in older adults; however, this relationship was not observed in younger adults. Further research is needed to understand the shared neural mechanisms underlying age-related declines in mobility and cognitive function.

Aging is accompanied by progressive deterioration in physiological homeostasis, increasing vulnerability to metabolic, neurodegenerative, cardiovascular, and immune disorders. Over the past two decades, circadian biology has emerged as a central integrative framework linking environmental time cues to cellular, tissue, and organismal resilience. The circadian timing system (CTS), composed of a central pacemaker in the suprachiasmatic nucleus (SCN) and peripheral clocks throughout the body,...

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Dementia arises from a complex interplay of biological, psychological, and sociocultural factors. However, previous large-scale studies have largely focused on biomarkers and genetics, with limited attention to the social and structural determinants of health that shape diverse aging trajectories. The Brain Resilience Study (BRS) addresses this gap by integrating multimodal biological and cognitive measures with rich demographic, psychosocial, and lifestyle data to create an open resource for...

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The proteasome is essential for cellular protein homeostasis through selective destruction of damaged and misfolded proteins. Failure of proteasome-dependent turnover accompanied by accumulation and aggregation of aberrant proteins is a hallmark of aging and late-onset neurodegenerative diseases. SKN-1A/Nrf1, a member of the NFE2L/Nrf family of transcription factors, is a master regulator of proteasome biogenesis. Through transcriptional control of proteasome subunit gene expression, SKN-1A/Nrf1...

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CONCLUSIONS: Intrinsic capacity impairment is associated with compromised HRQoL both directly and indirectly by exacerbating functional dependence. Preserving functional independence serves as a key pathway connecting intrinsic capacity to well-being. These findings highlight the imperative for integrated interventions that simultaneously bolster intrinsic capacity and support daily functional ability, tailored to diverse living environments to promote healthy aging.

An important hallmark of aging-and particularly of neurodegeneration-is the loss of proteostasis, leading to cellular stress. However, the causal mechanisms driving this loss are unclear. We show that SIRT6 has a critical role in maintaining proteostasis. Mechanistically, SIRT6 negatively regulates global translation by controlling ribosomal genes, nucleolar function and TIP5 chromatin localization. SIRT6 deletion increases nucleolar size, rRNA production and protein translation. However, the...

CONCLUSIONS: This study demonstrates that routine physical examination information could be a valuable component to incorporate into targeted assessments to screen low muscle mass among community-dwelling older adults. Building on this foundation, an interpretable machine learning approach was explored, which proves well-suited as a screening manner for low muscle mass to guide further standard assessment. Its suitability stems from superior predictive performance and operational feasibility in...

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CONCLUSIONS: Our findings suggest that PM2.5 exposure was associated with increased AD risk, primarily through direct rather than comorbidity-mediated pathways. Stroke may modestly increase susceptibility. These findings highlight the need for air quality interventions as part of dementia prevention strategies in aging populations, especially those facing overlapping environmental and clinical vulnerabilities.