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Daily briefing: Why cancer might protect against Alzheimer's disease
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Discovery of NIRF theranostic probes targeting amyloid-beta and cholinesterases in Alzheimer's disease models
Alzheimer's disease (AD) remains a major unmet medical challenge, with limited tools that integrate early diagnosis and therapeutic intervention. Considering the pivotal roles of amyloid-β (Aβ) and cholinesterases (ChEs) in AD etiology, we report dual-functional theranostic NIR-I probes. The lead candidate, I-43, exhibits favorable NIR optical properties (Stokes shift ≥ 220 nm) and binds strongly to Aβ fibrils, with K(d) values of 58.2 ± 9.7 nM for Aβ(1-40) and 104 ± 25 nM for Aβ(1-42)....
Falls as a Predictor of Future Dementia in Middle-Aged and Older Adults: A Systematic Review and Meta-Analysis
CONCLUSIONS AND IMPLICATIONS: This study demonstrates that multiple falls are a significant predictor of future dementia and highlights the importance of fall frequency. Recurrent falls may serve as a potential clinical marker for identifying individuals at higher risk. Clinicians should maintain heightened vigilance for cognitive decline in middle-aged and older adults with a history of recurrent falls to facilitate early detection of dementia. Given the limited evidence base and high...
The role of social context in cognitive and neurobehavioural outcomes in epilepsy
Cognitive and psychiatric comorbidities are among the most persistent and disabling challenges experienced by children and adults with epilepsy, with serious implications for daily functioning, health-care utilization, long-term social outcomes and quality of life. Traditionally, research has focused on epilepsy-specific biological risk factors, such as seizure frequency or epilepsy syndrome, but growing evidence indicates that non-medical factors also shape neurodevelopmental, cognitive and...
The association of eight-year trajectories in total, cognitive-affective, and somatic depressive symptoms with incident stroke: a 10-year follow-up study using HRS and ELSA cohorts
CONCLUSION: Trajectories of total depressive symptoms marked by escalation, instability, or sustained elevation exhibited significantly elevated stroke risk. In contrast, individuals displaying decreasing depressive symptoms exhibit stroke risk comparable to those maintaining consistently low levels. Specifically, an ascending trajectory of cognitive-affective symptoms, alongside unstable and persistently elevated trajectories of somatic symptoms, are linked to increased stroke risk. These...
Single-cell analysis of microglial activation after traumatic brain injury reveals immune signaling pathways linked to mitochondrial dysfunction and brain aging
CONCLUSION: This study provides the first integrative single-cell transcriptomic map of microglial-myeloid interactions after TBI across multiple tissues and time points, linking microglial signaling to mitochondrial dysfunction and neuroinflammation. These findings lay the foundation for therapeutic strategies targeting myeloid-driven immune regulation in TBI.
The interplay of homeostasis, inflammation, and oxidative stress in neurodegenerative disorders: the role of biological markers, antioxidants, lithium, and TMS - a proposed framework for preventing neurodegenerative disorders through biomarkers and…
Neurodegenerative diseases such as Alzheimer's disease (AD) and Parkinson's disease (PD) are among the most significant health challenges of aging, characterized by progressive cognitive and motor decline. Increasing evidence suggests that these conditions are not inevitable outcomes of aging but may instead be driven by preventable mechanisms involving oxidative stress, chronic inflammation, and disruptions in homeostasis. This manuscript proposes a preventive framework that integrates...
Axonal distribution of mitochondria maintains neuronal autophagy during aging via eIF2beta
Neuronal aging and neurodegenerative diseases are accompanied by proteostasis collapse, while the cellular factors that trigger it have not been identified. Impaired mitochondrial transport in the axon is another feature of aging and neurodegenerative diseases. Using Drosophila, we found that genetic depletion of axonal mitochondria causes dysregulation of protein degradation. Axons with mitochondrial depletion showed abnormal protein accumulation and autophagic defects. Lowering neuronal ATP...
Why do women like me get diagnosed with ADHD late?
Audio long read: ‘I rarely get outside’ — scientists ditch fieldwork in the age of AI
Scalable and multiplexed recorders of gene regulation dynamics across weeks
Exceeding 1.5 °C requires rethinking accountability in climate policy
As we breach 1.5 °C, we must replace temperature limits with clean-energy targets
Technology is changing how we write — and how we think about writing
Quantum spinning effect observed in a levitating magnet
Defending endangered trees against climate change and hungry goats
U.S. government has lost more than 10,000 STEM Ph.D.s since Trump took office
A Science analysis reveals how many were fired, retired, or quit across 14 agencies
Controversial Chilean energy project scrapped, relieving astronomers
Light pollution from green hydrogen plant would have threatened world’s largest telescopes
Oldest wooden tools may have been used to butcher elephants
Branches sharpened 400,000 years ago shine light on humans’ early toolmaking
Tidal waves of lava may slosh around alien worlds
Waves of molten rock could be confounding observations of atmospheres on distant planets