Aggregator

Researchers found that insulin-producing cells depend on a team of helper proteins to keep insulin production on track. When one key partner was missing, damaged proteins built up and the cells made less insulin. Strengthening this system could offer a new way to protect the pancreas as diabetes progresses.

A healthy lifestyle can prevent type 2 diabetes for many people, but new research suggests that weight loss alone may not be enough for one particularly vulnerable group. Even after losing about 8% of their body weight and keeping it off for years, people in a high-risk category known as cluster 5 continued to experience rising blood sugar, weakening insulin production, and a strong risk of developing diabetes.

PurposeTo identify the predictors of the technology-assisted behaviors older adults would consider implementing once encountered with a health concern and seeking help. To understand this phenomenon, the study tapped into the technology familiarity approach and the media richness theory.MethodsData were obtained from the 2020 wave of the Ageing, Communication, Technologies (ACT) survey and analyzed using logistic regression models. The sample included 3,926 internet users 63-97 years old from...

Age-related cognitive decline is increasingly recognised as arising from interacting immune and neurovascular vulnerabilities rather than from isolated insults. In this Review, we synthesise current human and mechanistic evidence within a convergence framework in which inflammaging and neurovascular unit (NVU) dysfunction are conceptualised as a feedback-coupled system. Persistent immune remodelling may promote endothelial activation, redox imbalance, pericyte-astrocyte support failure,...

A major review found that exercise produces only small average improvements in hip osteoarthritis pain and physical function. It may still help some people, but researchers warn that current evidence is too limited to know which exercises work best.

A single 30-minute sauna session may briefly put the immune system on higher alert. Finnish researchers found that sauna heat, paired with a short cold shower, increased every type of white blood cell circulating in the bloodstream, including key infection fighters such as neutrophils and lymphocytes.

Dreams are not random mental noise. A large study of more than 3,700 dream and waking reports found that what we experience during sleep is shaped by both our personalities and the world around us. Rather than simply replaying daily events, the dreaming brain mixes memories, emotions, imagined possibilities, and familiar settings into vivid new scenarios.

Unsweetened sparkling water may offer a tooth-friendlier alternative to sugary soda, according to a small preliminary study tracking how different drinks change mouth acidity. Soda caused the strongest and longest drop in salivary pH, while sparkling water produced only a temporary decline before saliva restored normal conditions. Importantly, acidity remained above the level associated with enamel damage.

Population declines led to spike in spinal deformities and rare tumors, fossil study suggests

Wogonin, a naturally occurring flavonoid derived from Scutellaria species and widely used in traditional East Asian medicine for its anti-inflammatory and antioxidant effects. Although wogonin has demonstrated efficacy against oxidative stress and inflammation, its mechanistic role in Parkinson's disease (PD) remains incompletely understood. The present study investigated the neuroprotective potential of wogonin in a rotenone-induced mice model of PD, with particular emphasis on modulation of...

CONCLUSIONS: The findings indicate that the cognitive effects of multi-session resistance exercise are domain-specific rather than uniform across cognitive abilities. Resistance exercise appears particularly promising for supporting cognitive processes involving executive control, working memory, and rapid information processing. However, interpretation should remain cautious given heterogeneity across studies, limited evidence in some domains, and variation in intervention duration, intensity,...

CONCLUSION: A putative epigenetic relation was found between miR-124 levels and their association with SIRT1. The investigated biomarkers of aging are associated with serum concentration of 25(OH) vitamin D in a middle-aged vitamin D-deficient rat model, which supports the need for mechanistic investigation in future studies.

Estrogen receptor-positive (ER^(+)) breast cancer is the most common subtype of breast cancer and is an age-related disease. How systemic and tumor microenvironment hormone signaling intersects with chronic inflammation and how this shapes aging-associated tumor biology remain incompletely understood. Here, using an aged rat model of ER^(+) tumors, we identify age-associated differences in tumor development and immune features. In parallel, analysis of samples from patients with ER^(+)/HER2^(-)...

Single-cell foundation models such as scGPT and Geneformer are large neural networks trained on human single-cell RNA-seq data. They were never shown chronological age during training. Do their internal representations nevertheless encode aging biology in a way that can be interpreted, and how should we test whether an apparent aging signal is real biology rather than an artifact of which donors and cell types happened to be sampled?. We applied a nine-step evaluation pipeline to two foundation...