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These tiny holes could change how the world cleans water

8 hours 16 minutes ago
A new nature-inspired membrane uses perfectly uniform one-nanometer pores to filter molecules with remarkable precision. The technology could transform industries such as pharmaceuticals and textiles by reducing energy consumption, improving water reuse, and delivering separation performance far beyond current filters.

Co-occurrence network characteristics and key comorbidity node identification based on health examination indicators among rural older adults aged 65 and above

11 hours 29 minutes ago
CONCLUSIONS: Abnormal health indicators among rural older adults exhibit a metabolism-centered and systemically interconnected co-occurrence pattern. Fatty liver, diabetes, and hypertension are structurally central nodes in the network, highlighting their prominence rather than implying causality. Females show stronger indicator interconnections, and advanced age is associated with more complex co-occurrence patterns. These findings provide network-based, hypothesis-generating evidence to...
Dongmei Huang

Social frailty as a predictor of mortality among older adults in four Colombian departments: evidence from the SABE survey

11 hours 29 minutes ago
CONCLUSIONS: Social frailty was independently associated with all-cause mortality among older adults in this Colombian regional cohort. These findings suggest that incorporating social vulnerability measures into geriatric assessment may improve risk stratification and help identify individuals who could benefit from supportive interventions.
Hernán-David García-Botina

Digital technology use for social cohesion among older adults in rural Myanmar during the civil war: barriers and coping strategies

11 hours 29 minutes ago
CONCLUSION: Digital technologies provide a limited but meaningful contribution to sustaining social cohesion among older adults in rural, conflict-affected Myanmar by supporting communication, emotional connection, and access to information. However, their contribution remains uneven, as structural inequalities, political constraints, and infrastructural limitations continue to restrict equitable access. Addressing these challenges requires context-sensitive, age-appropriate digital inclusion...
Ruth Hkawn Awng

Cell stress and death liberate the autophagy-inhibitory tissue stress hormone DBI/ACBP into the circulation

11 hours 29 minutes ago
Autophagy constitutes a major adaptive response that preserves cellular and organismal homeostasis during stress. However, stress responses also engage systemic communication pathways that may either maintain resilience or propagate pathology. We previously identified acyl-CoA-binding protein, also known as diazepam-binding inhibitor (DBI/ACBP), as a phylogenetically conserved extracellular factor secreted by stressed cells through an unconventional autophagy-dependent pathway. Once released,...
Yan Rong

Scientists found the strength training sweet spot for a longer life

16 hours 42 minutes ago
Just 90–120 minutes of strength training a week may deliver some of the biggest long-term health rewards, according to a study tracking more than 147,000 people for 30 years. That amount was linked to lower risks of death overall, particularly from cardiovascular and neurological diseases. Combining strength workouts with aerobic exercise produced even stronger benefits.

The deadly tapeworm spreading across America has reached the Pacific Northwest

1 day 7 hours ago
A potentially dangerous tapeworm linked to severe, cancer-like disease has now been found in the Pacific Northwest, marking its first detection in wild animals along the U.S. West Coast. Researchers discovered the parasite, Echinococcus multilocularis, in 37% of coyotes tested around Puget Sound—a surprisingly high rate for a region where it had never been reported until recently.

Caloric restriction rejuvenates aged adult stem cells: From mechanisms to interventions

1 day 11 hours ago
Adult stem cells are essential for maintaining tissue homeostasis and facilitating tissue repair. The ability of aged stem cells to generate functional progeny declines, which is closely associated with the onset and progression of age-related diseases. The aging of adult stem cells in various tissues is regulated jointly by local microenvironments (stem cell niches) and systemic factors. Caloric restriction (CR), a widely studied anti-aging strategy, has been demonstrated to rejuvenate aged...
Yan Chai

NAT10 inhibition alleviates renal tubular epithelial cell senescence by impeding ac4C acetylation of PAPP-A mRNA in diabetic nephropathy

1 day 11 hours ago
Cellular senescence plays a critical role in diabetic nephropathy (DN). Understanding the mechanisms underlying the senescence response is therefore essential for developing effective therapies for DN. In this study, we provide evidence that NAT10 expression was markedly elevated in the kidney tissues of patient with DN and was associated with adverse clinical outcomes. NAT10 directly bound to PAPP-A, induced ac4C acetylation modification of the PAPP-A transcript, and enhanced its stability,...
Mingyang Hu

Proteomics-based insights into mammalian oocyte and early embryo development

1 day 11 hours ago
Advances in proteomics are transforming our understanding of mammalian oocyte maturation and preimplantation embryo development. These resources and their findings provide unprecedented insights into the molecular underpinnings of developmental competence. Here we summarize the ongoing development of proteomic methodologies and highlight the stage-specific reprogramming events of the proteome in both humans and mice, underscoring the unique utility of proteomics in deciphering oocyte maturation...
Sifan Rong