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3 minutes of sprinting does something 90 minutes of exercise does not

16 hours 55 minutes ago
A few minutes of sprinting may reshape the bloodstream far more dramatically than a much longer moderate workout. Six 30-second sprints altered nearly a quarter of the blood proteins measured and more than 200 metabolites, while 90 minutes of moderate cycling produced far smaller immediate changes. Many of the proteins affected by sprinting were also associated with lower risks of obesity, type 2 diabetes, and other metabolic diseases.

This weight-loss hormone may protect the liver even without weight loss

17 hours 34 minutes ago
A hormone already known for curbing appetite and supporting weight loss may have a surprising second job: protecting the liver from inflammation and scarring. Researchers at McMaster University found that GDF15 activates a previously unknown brain-to-liver pathway that triggers the release of glucocorticoids, helping calm immune activity in the liver.

AI may know how you’ll respond to a vaccine before you get it

18 hours 13 minutes ago
AI may be able to predict how strongly someone will respond to a vaccine before they receive it. By analyzing antibody patterns in more than 4,000 people, researchers found signs of “immune readiness” that helped distinguish strong responders from weak ones. Surprisingly, even some healthy people responded poorly, while some immunosuppressed people mounted strong responses.

Cortical-to-pallidal beta cascade underlies network pathophysiology in Parkinson's disease

19 hours 13 minutes ago
Parkinson's disease (PD) motor symptoms are linked to excessive beta band (13-35 Hz) oscillations and basal ganglia-cortical (BGC) synchrony, yet their dynamic inter-relation remains unclear. Based on computational modeling, we hypothesize that transient high-beta (20-35 Hz) BGC coupling induces subcortical low-beta (13-20 Hz) amplification. We recorded intraoperative neural signals from the globus pallidus internus and externus (GPi and GPe, respectively) and motor cortex (M1) in 23 PD patients...
Jeong Woo Choi

The Heart-Brain-Emotion Axis in Aging: An Integrated Framework Linking Cardiovascular Dysfunction, Emotional Dysregulation, and Cognitive Decline

19 hours 13 minutes ago
Population aging is accompanied by a parallel increase in cardiovascular disease (CVD), vascular cognitive impairment (VCI), and dementia, highlighting the urgent need to better understand the complex interactions linking cardiovascular, cognitive, and emotional health. Growing evidence suggests that cardiovascular dysfunction, emotional dysregulation, and cognitive decline are not isolated conditions but interconnected manifestations of shared vascular, inflammatory, neurohumoral, metabolic,...
Alessia Di Salvo

Senescent repair memory in chronic disease: failed resolution as a driver of persistent organ dysfunction

19 hours 13 minutes ago
Chronic diseases can continue to progress after the initiating insult has subsided, indicating that injured tissues may retain a persistent imprint of failed repair. Here, senescent repair memory refers to a tissue state in which transient repair-associated senescence fails to resolve and is maintained by persistent senescent cells, altered secretory and metabolic programmes, defective immune clearance, epigenetic stabilization and spatial niche interactions. Once established beyond the adaptive...
Hongtu Hu

E3 Ubiquitin Ligases Molecular Strategies Against Proteostasis Defects of Imperfect Ageing

19 hours 13 minutes ago
Ageing is a process of continuous decline of cellular health. This decline could be attributed to loss of functions to various crucial protein players regulating the triage of cellular physiology. Systematic decline of cellular proteostasis is one major change that orchestrates alterations in functioning of other biological indicators, including cellular energetics, signal transduction, and metabolic adaptation. Among many molecular players governing physiological changes, E3 ubiquitin ligases...
Arun Upadhyay

Slow bleaching of water-insoluble brown carbon from biomass burning: Implication for direct radiative effect

19 hours 13 minutes ago
Biomass burning organic aerosol (BBOA) is a major source of atmospheric brown carbon (BrC), which contributes to climate through solar radiation absorption. Chemical aging (bleaching) of BrC diminishes light absorption over time. Although recent modeling studies have emphasized the need to account for bleaching when assessing BrC's climate impacts, a parameterization representing the entire BBOA matrix has been lacking. Here, we develop a bleaching parameterization for the whole BrC in BBOA...
Wenli Liu

Geneformer-guided multiomics integration identifies Pbx1 as a network hub of hematopoietic stem cell aging

19 hours 13 minutes ago
Hematopoietic stem cells (HSCs) constitute an organized hematopoietic system that undergoes age-related alterations, including increased platelet production and decreased erythropoiesis. The fundamental mechanisms driving these shifts remain incompletely understood. We used single-cell RNA sequencing data to show that old HSCs contain two distinct transcriptional programs: one shared with megakaryocytes and the other reflecting the most primitive HSC state. Developmental time-series profiling...
Hiroshi Kobayashi

Region-specific brain metabolite reference estimates and exploratory age-related changes in cognitively intact older adults: a preliminary deep-learning <sup>1</sup>H-MRS study

19 hours 13 minutes ago
CONCLUSION: This study established preliminary, cohort-specific multi-regional ¹H-MRS reference estimates for cognitively intact older adults, with robust regional profiles and large effect sizes. The PCC showed exploratory age-related change-most consistently a coordinated aspartate-glutathione decline-requiring confirmation in larger cohorts, whereas the OC emerged as a candidate metabolically stable region.
Young-Ah Choi

RICTOR Prevents Decidualization Disorder in Women With Advanced Maternal Age via Regulating FoxO1 Nuclear Export

19 hours 13 minutes ago
Miscarriage and abnormal embryonic development in women of advanced maternal age (AMA) are often associated with impaired decidualization. mTORC2 is an evolutionarily conserved protein kinase. As a core component of mTORC2, RICTOR has been implicated in nutrient sensing and is closely linked to implantation disorders; however, its role in regulating age-related decidualization disorders remains unreported. In this study, we identified pronounced decidualization defects in AMA foster mice,...
Yifeng Lin

hTERT Immortalization Stabilizes Human Umbilical Cord MSCs and Maintains Their Small Extracellular Vesicles With Preserved Immunomodulatory Activity and Primordial Follicle-Activating Capacity

19 hours 13 minutes ago
Cellular senescence is a fundamental hallmark of aging and represents a major barrier to the scalable and reproducible application of mesenchymal stromal cell (MSC)-derived small extracellular vesicles (sEVs). Senescent human umbilical cord mesenchymal stromal cells (hUCMSCs) exhibit impaired proliferative capacity, disrupted mitochondrial homeostasis, and altered secretory phenotypes, which may compromise the biological activity and therapeutic reliability of sEVs. Here, we investigated whether...
Yating Chen

Hyaluronan deficiency disrupts endothelial glycocalyx integrity and contributes to age-related arterial dysfunction

19 hours 13 minutes ago
Aging is accompanied by arterial dysfunction, defined by impaired endothelial function and increased large artery stiffness, yet the contribution of the endothelial glycocalyx (eGC) and its constituent, hyaluronan (HA), to this process remains incompletely understood. We tested the hypothesis that decreasing endothelial HA synthesis via a reduction in endothelial-specific HA synthase 2 (HAS2) compromises eGC integrity and contributes to arterial dysfunction with advancing age. Both...
Jisok Lim

The Thymic Microenvironment Shapes Age-Related Qualitative Changes in the TCR Repertoire

19 hours 13 minutes ago
Ageing impairs immune function, increasing susceptibility to infection, autoimmunity and inflammation. The thymus undergoes involution during childhood, and thymocyte and thymic epithelial cell (TEC) numbers decline. Given that adaptive immunity depends on T-cells recognising diverse antigens via their unique T-cell receptor (TCR), the precise age-related changes in TCR repertoire composition are key to understand immunity. To investigate the influence of age on the thymic TCR repertoire we...
Jasmine Rowell

Molecular Mechanisms of Age-Related Taste Dysfunction Deciphered by Spatiotemporal Transcriptomics

19 hours 13 minutes ago
Age-related taste dysfunction impairs nutrition and quality of life, contributing to metabolic disorders and frailty in the elderly, yet its cellular and molecular basis remains poorly understood. By integrating single-cell RNA and spatial transcriptomics sequencing, we systematically mapped murine taste bud aging across five developmental stages from neonatal to aged. Our findings reveal that age-associated taste impairment is driven by the progressive depletion of stem/progenitor cell...
Wandong Zhao

Surviving Fibroblasts After Treatment With Mitomycin C Exhibit SASP-Like Phenotype After Glaucoma Filtration Surgery

19 hours 13 minutes ago
The clinical outcomes of trabeculectomy, a standard glaucoma filtration surgery (GFS), have dramatically improved with the introduction of mitomycin C (MMC), an antimetabolite widely used to inhibit postoperative scarring. MMC exerts anti-scarring effects primarily by promoting apoptosis and suppressing fibroblast proliferation at the surgical site. However, despite these beneficial effects, MMC also induces the production of inflammatory cytokines, and its full mechanism of action remains...
Akitoshi Kimura

Aged Mitochondrial DNA Is Associated With Aberrant Acute Exercise-Induced Redox Responses in Human Skeletal Muscle

19 hours 13 minutes ago
Redox imbalances and mitochondrial dysfunction are key contributors to age-related declines in skeletal muscle and may contribute to impaired exercise responsiveness. Here, we investigated the influence of aging on skeletal muscle redox at rest and in response to acute exercise, examining how mitochondrial quality and quantity relate to skeletal muscle redox status. Skeletal muscle biopsies were obtained from 12 young (22 ± 4 years) and 10 older adults (66 ± 7 years) before and immediately after...
Bradley A Ruple

Aging Alters Hair Cell Physiological Properties in Mice With Late-Onset Age-Related Hearing Loss

19 hours 13 minutes ago
Mammalian cochlear hair cells convert acoustic stimuli into electrical signals, which are relayed to the central auditory pathway via auditory neurons. Progressive loss of hair cells and their synapses is a characteristic of age-related hearing loss (ARHL), but the underlying mechanisms remain poorly understood. In this study, we tested the hypothesis that hair cell physiological properties change with age in CBA/CaJ mice, a strain known for its slow ARHL progression. We found that hair cell...
Piece Yen