Skip to main content

Aggregator

Gene therapy targeting synaptopathy linked with Alzheimer's and Parkinson's disease

1 day 13 hours ago
Synaptic Plasticity pertains to the synapse's tendency to adapt fresh information and is a crucial step in the establishment of brain circuits that aid in memory formation. It has become one of the most intensively researched topics in all of neuroscience. Pieces of evidence are accumulating that synaptopathy (altered synaptic plasticity) mechanisms contribute to Alzheimer's disease (AD) and Parkinson's disease (PD). Toxins responsible for synaptopathy and aberrant neurotransmitter (NT) release...
Siva Prasad Panda

How cytochrome P450 enzymes in humans are involved in Parkinson's disease: a literature review

1 day 13 hours ago
This review synthesizes three decades of evidence regarding the role of cytochrome P450 enzymes (CYPs) in Parkinson's disease (PD), revealing their multifaceted roles beyond traditional pesticide metabolism. While CYP2D6 remains the most studied enzyme due to its association with PD risk in poor metabolizer phenotypes and its dual role in dopamine (DA) synthesis (directly via tyramine hydroxylation and indirectly through precursor demethylation), recent research has highlighted less-studied CYPs...
Bingyi Ren

S-nitrosoglutathione reductase GSNOR drives age-related obesity by promoting adipose tissue whitening through de-nitrosation of Beclin-1

1 day 13 hours ago
Age-related obesity is a growing public health concern linked to various metabolic disorders, yet its underlying mechanisms remain incompletely understood. Here we report that S-nitrosoglutathione reductase (GSNOR), a pivotal denitrosation enzyme, increases in adipose tissue of both male mice and humans from middle-age. GSNOR knockout protects against age-related weight gain and enhances metabolism, whereas adipose-specific GSNOR knock-in mice promotes obesity and metabolic decline. Further...
Xinhua Qiao

Attenuating age-related decline in dendritic cell migration improves vaccine efficacy via gut-immune crosstalk

1 day 13 hours ago
Aging impairs immune function and reduces vaccine efficacy, but whether dendritic cells (DCs), which play a central role in initiating immune responses via antigen presentation, contribute to this decline remains unclear. Through single-cell RNA sequencing analysis of lymph node changes upon vaccination in young versus aged mice, here we identify defects in DC migration during aging, alongside a dysfunction-associated gene signature in migratory DCs, and implicate these defects in the diminished...
Huaxing Dai