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Snakes on a train? Deadly reptiles may be hopping railcars in India
Trains may be transporting cobras and other venomous snakes to new parts of the country
In a twist, polar bears are getting fatter in the Norwegian Arctic
With sea ice dwindling, the massive predators are relying more on land-based food sources such as reindeer
Advancing depression assessment in older adults with cancer: Development and validation of the Older Adults with Cancer-Depression Scale (OAC-D), a novel, patient-reported outcome
CONCLUSIONS: The OAC-D identified five unique domains of depression, only one of which overlapped with DSM criteria. It demonstrated robust psychometric properties, providing a nuanced alternative to DSM-based measures and addressing the distinctive psychological challenges of cancer and aging.
Longitudinal association between oral health and dementia among older adults: evidence from the Korean longitudinal study of ageing
No abstract
Associations Between 40-Year Trajectories of BMI and Proteomic and Epigenetic Aging Clocks: Deciphering Nonlinearity and Interactions
The potential of proteomic aging clocks for obesity research, and the extent of nonlinearity in longitudinal associations between body weight and biological aging, remain underexplored. We investigated how BMI at ages 18 and ~60, as well as changes in BMI from age 18 to ~60, relate to downstream epigenetic and proteomic aging. We also examined nonlinearity and interactions in these associations. Analyses were conducted in 401 Finnish twins with up to nine self-reported or measured BMI values...
The aggregate proteome of Caenorhabditis elegans mitochondria implicates shared mechanisms of aging and Alzheimer's disease
CONCLUSION: These findings place mitochondrial proteome collapse at the center of aging and AD-seeded pathology, distinguish Aβ- and Tau-driven proteotoxic routes, and nominate a conserved panel of aggregation-prone proteins as mechanistic drivers and candidate biomarkers for early detection and intervention in AD.
The ‘undone science’ of opioid overdose deaths
Science, Volume 391, Issue 6784, January 2026.
The origin of hepatocellular carcinoma depends on metabolic zonation
Science, Volume 391, Issue 6784, January 2026.
Wafer-scale ultrathin and uniform van der Waals ferroelectric oxide
Science, Volume 391, Issue 6784, January 2026.
High-precision tracking of human foragers reveals adaptive social information use in the wild
Science, Volume 391, Issue 6784, January 2026.
DNA-protein cross-links promote cGAS-STING–driven premature aging and embryonic lethality
Science, Volume 391, Issue 6784, January 2026.
The evolution of gene regulation in mammalian cerebellum development
Science, Volume 391, Issue 6784, January 2026.
Engineered aldehyde dehydrogenases for amide bond formation
Science, Volume 391, Issue 6784, January 2026.
Aging drives a program of DNA methylation decay in plant organs
Science, Volume 391, Issue 6784, January 2026.