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A large study found that women taking GLP-1 drugs, the medication class behind Ozempic, Wegovy, Mounjaro, and Zepbound, were about 30% less likely to develop breast cancer. Researchers say the findings are promising but not yet proof, and clinical trials are now being planned to test whether these drugs could help prevent breast cancer.

Supplements are often marketed as shortcuts to better health, but for many older adults, the real issue is whether they have a specific deficiency. Vitamins like B12 and D can play an important role when levels are low, while protein may be one of the most overlooked nutrients for maintaining strength and independence. More isn’t always better, though—some supplements can cause harm or interact with medications.

Scientists warn that free-living amoebae may be an underappreciated public health threat, capable of causing deadly infections and shielding other dangerous microbes from water treatment. Climate change and aging infrastructure could help these resilient organisms spread more widely in the years ahead.

This study aims to investigate the mechanism by which extract of Dendrobium officinale leaves (EDL) extends the lifespan of Caenorhabditis elegans. Untargeted metabolomics and network pharmacology analyses revealed that EDL primarily contains active components such as fatty acids, flavonoids, and polyphenols, which are predicted to potentially modulate pathways including MAPK, AMPK, mTOR, and longevity-related signaling pathways. Experimental results showed that 2 mg/mL EDL significantly...

The ageing population and the increasing prevalence of age-related diseases underscore the urgent need for targeted therapeutic strategies. Accumulating evidence indicates that quinolinic acid (QA), a neuroinflammatory neurotoxin, contributes to the pathogenesis of neurodegenerative disorders. In this study, using Caenorhabditis elegans as a model organism, we demonstrate that chronic QA exposure acts as a robust driver of accelerated aging, significantly reducing overall healthspan. This...

Higher cardiorespiratory fitness (CRF) has been linked to healthier brain ageing, which includes preservation of white matter (WM) tracts. However, whether CRF might help preserve whole-brain WM networks and whether this varies with age remains unclear. To address this gap, we used cross-sectional data from The Maastricht Study (N = 4432, mean age 59.2 ± 8.7 years, range 40-79, 51% female). We derived CRF estimates from submaximal ergometry (VO(2)-max) and WM network metrics (whole-brain node...

Scientists have successfully tested an AI-designed universal coronavirus vaccine in humans for the first time, finding it to be safe and well tolerated. The vaccine generated immune responses against multiple coronaviruses, including SARS-CoV-2, SARS, and related bat viruses with pandemic potential. By targeting features shared across an entire virus family, it aims to provide protection even as viruses evolve.

Scientists have identified genetic variants that may make some people less responsive to GLP-1 drugs used to treat Type 2 diabetes. Roughly 10% of the population carries these variants, which appear to cause a mysterious form of "GLP-1 resistance." In several clinical trials, carriers were significantly less likely to reach healthy blood sugar targets while taking GLP-1 medications.

Cancer and cell aging studies may have relied on antibodies to incorrect molecule

The mechanism(s) causing selective vulnerability of dopaminergic neurons in Parkinson's disease (PD) remain largely elusive. To improve our understanding of mitochondrial involvement and related pathways suggested to play a role in this selective vulnerability, we used tyrosine hydroxylase (TH)-mCherry reporter-induced pluripotent stem cells generated by CRISPR/Cas9. We sorted neurons into pure TH-positive and TH-negative neurons upon differentiation into a dopaminergic neuron-containing cell...

Microglia play crucial roles in Alzheimer's disease (AD), yet the molecular mechanisms are unclear. Here, we show that CD31, a recognized endothelial marker, is predominantly expressed in microglia but not in neurons or astrocytes, and it is significantly elevated in the brains of AD patients and mouse models. Microglia-specific CD31 knockdown in 5xFAD mice substantially attenuated the dysregulated transcription networks, suppressed microglia hyperactivation and the disease-associated microglia...

Neurodegenerative diseases, such as Mild Cognitive Impairment (MCI) and Alzheimer's, pose significant challenges due to their progressive nature and late diagnosis. Early detection remains difficult, particularly when using conventional machine learning approaches that fail to capture complex spatial and temporal patterns in multimodal clinical data. Motivated by the need for accurate, scalable, and clinically applicable diagnostic tools, this study proposes a hybrid deep learning framework...

Protollin, a nasal adjuvant, was evaluated in a randomized double-blind phase 1 study of 16 early Alzheimer's disease (AD) patients to determine safety and to assess its immunomodulatory effects. In a double-blind dose escalation study, subjects received nasal Protollin at doses of 0.1 mg, 0.5 mg, 1.0 mg, and 1.5 mg or placebo twice over a two-week period. Treatment was well-tolerated with minimal side effects. Transcriptomic and single-cell analyses demonstrated that prior to treatment, AD...

The properties of functional brain networks are an important determinant of cognitive function in aging and dementia. Despite this, few studies have comprehensively examined demographic and biopsychosocial predictors of functional brain networks, and none have attempted to do so across the adult lifespan while accounting for collinearity among these predictors. The current study used data from 525 individuals between the ages of 35 and 100 years from the Human Connectome Project 2.0 Lifespan...

Andes virus (ANDV) is the most virulent New World orthohantavirus, responsible for hantavirus cardiopulmonary syndrome (HCPS)-a severe and frequently fatal disease characterized by non-cardiogenic pulmonary edema, vascular collapse, and dysregulated immune activation. The April 2026 outbreak of ANDV aboard the cruise ship MV Hondius, in which several older adults were among those most severely affected, has renewed attention to host age as a potential determinant of disease severity. Although...

CONCLUSIONS: Our findings suggest that MetS may play a significant role in the development and progression of frailty. Accordingly, targeting MetS could be a viable approach for preventing or delaying the onset of frailty in older adults.

In Indonesia, adults living in rural areas have a longer life expectancy than their urban counterparts. Beyond observed longevity, attention has focused on lifespan and healthspan expectations as predictors of health outcomes. This study examines expected lifespan and expected healthspan and their associated factors among rural and urban populations in Java, Indonesia. The cross-sectional Healthy Longevity (HELO) survey collected data from the general population using in-person interviews and an...

CONCLUSIONS: Perceived control over falling among older adults with CaF is a dynamic, multidimensional process that extends beyond physical risk factors. Fall-prevention interventions should therefore move beyond purely physical components to incorporate psychological, social, and life-course dimensions, supporting adaptive appraisals, resilience, independence, and sustained engagement in daily life.

Heterointerface degradation under operational stress represents a critical limitation to perovskite solar cell longevity. Here, we demonstrate contrasting aging behaviors between bulky anionic and cationic passivators at heterointerfaces, wherein anionic species induce lattice expansion under thermal stress. To address the thermal instability of conventional passivators, we synthesized cesium pyridine-3-carboxylate, which triggers reactive surface reconstruction, suppresses ion migration, and...

Do viral infections accelerate aging, and does this acceleration scale with pathogenicity? Using transcriptomic aging clocks, we measured biological age in Drosophila melanogaster infected with four enteric RNA viruses spanning a broad pathogenicity range (i.e., reduction of host lifespan). All pathogenic infections accelerated aging and the magnitude of acceleration tracked pathogenicity. This pattern held across oral and systemic infection routes and was conserved in Caenorhabditis elegans...