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Baker's yeast is a long-standing model for studying mechanisms of aging. Due to asymmetric division, yeast mother and daughter cells are distinguishable, and mother cells usually cease division after 15-25 budding events. However, yeast suspensions consist predominantly of young cells. Here we investigated whether, under harsh environmental conditions, replicative aging-defined by the number of buds produced-manifests at early replicative ages. To test this, we adapted a flow-cytometry-based...

Scientists have discovered why some people with a high genetic risk of Alzheimer’s remain mentally sharp into their 80s, uncovering a rare mutation that protects the brain from harmful protein buildup. The findings reveal a potential new way to prevent early brain damage and could pave the way for treatments that mimic this natural defense.

Scientists have uncovered a possible explanation for why some people struggle to taste food more than a year after recovering from COVID-19. By examining taste buds from patients with lingering symptoms, researchers discovered molecular abnormalities that weaken the signals responsible for detecting sweet, bitter, and savory flavors.

Walking just 3,000 steps a day could help slow Alzheimer’s-related brain changes, according to new research. Scientists discovered that physical activity was linked to less buildup of harmful tau proteins and nearly half the cognitive and functional decline, even in people already showing early signs of the disease. The strongest benefits appeared at 5,000 to 7,500 daily steps, suggesting that the popular 10,000-step goal may not be necessary.

Experts worry the proposed research could produce biased results

A discovery in tiny algae led to a Nobel Prize-winning breakthrough that allows scientists to switch brain cells on and off using light. The revolutionary technique has already helped researchers activate memories and is opening new possibilities for restoring vision and treating brain disorders.

α-synuclein (αS), amyloid-β (Aβ), and Tau aggregates are hallmarks of many neurodegenerative diseases, yet the prevalence and nature of their nanoscopic co-assemblies remain poorly understood. Here, we adapt a single-molecule pull-down (SiMPull) assay to profile αS, Aβ, and Tau co-assemblies across post-mortem brain tissue homogenates, soluble brain fractions, human serum, cerebrospinal fluid, and saliva. We show that αS-Tau co-assemblies are abundant across all sample matrices, accounting for...

Blood feeding in Anopheles mosquitoes is at the root of all malaria infections in humans and is supported by a range of physiological and behavioral adaptations. Since behavior is orchestrated at the level of the central nervous system, we surveyed the cellular diversity and spatial organization of the female Anopheles gambiae brain and compared it to other insect species. We then describe transcriptional changes associated with mosquito life history events with single brain and single-cell RNA...

Although semantic cognition remains behaviorally stable with age, neuroimaging studies report age-related alterations in response to semantic context. To address these inconsistent findings, we combined behavioral and magnetoencephalography (MEG) measures and examined the neural mechanisms underlying lexical-semantic processing in healthy aging. Forty-six Finnish-speaking adults across younger (22 - 32 years) and older (62 - 69 years) cohorts performed a semantic congruency judgment task on word...

Peripheral nerve injury (PNI) remains a major cause of long-term sensory and motor dysfunction, imposing a substantial clinical and socioeconomic burden worldwide. Although peripheral nerves possess intrinsic regenerative capacity, functional recovery is often incomplete because of the complex interplay among axonal degeneration, Schwann cell plasticity, neuroimmune responses, extracellular matrix remodeling, metabolic reprogramming, remyelination, and target reinnervation. Recent advances in...

CONCLUSIONS: Patient decision aids were common in kidney failure treatment decision-making interventions, but incorporation of geriatric-relevant SDM features varied across decision points, and few interventions were evaluated exclusively among older adults. Future interventions should tailor geriatric-relevant SDM features to specific treatment decisions to best support older adults in making kidney failure treatment decisions.

Age-related sensory decline impairs responses to balance disturbances, increasing fall risk. Evaluating gait and balance under sensory challenges can help reveal how this decline affects instability in older adults. This study (Clinicaltrials.gov NCT06345625) incorporates head movements to evaluate the effect of sensory function - cervical sensorimotor control, vestibular function, and visual acuity - on walking stability in aging and its relationship with falls through a novel augmented-reality...

Aging is a critical risk factor for intervertebral disc degeneration, a major contributor to chronic low back pain. Loss-of-function studies showed that SIRT6, a nuclear NAD^(+)-dependent deacetylase, maintains disc health. We therefore investigated whether long-term SIRT6 activation via systemic delivery of the small-molecular agonist MDL-800 improves disc health in 24-month-old mice. Studies revealed healthy disc morphology, enhanced cell viability, and lower degeneration scores following...