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Stanford Medicine researchers have discovered a naturally occurring molecule that may suppress appetite and reduce body weight much like Ozempic, but without several of its common side effects. The molecule, called BRP, acts on a more targeted region of the brain involved in hunger and metabolism rather than affecting tissues throughout the body.

A sulfur-based compound called LASSS appears to protect and supercharge a key protein involved in repairing damaged muscle. The discovery could eventually lead to new ways to slow muscle loss and preserve strength as people age.

An experimental pill prevented a measles-like virus from spreading through the air or through close contact in ferrets. It worked when given shortly before or after exposure and also shortened illness and the period when infected animals remained contagious. Researchers say the drug could one day complement vaccination and make outbreaks easier to contain.

With cancellation of health disparities project, agency may be testing new way to legally kill politically sensitive grants

Ozempic, Wegovy, and similar drugs may deliver excellent health value, but covering them for millions of eligible patients could overwhelm insurance budgets. Researchers say better long-term support is needed and warn that low-cost compounded versions may carry serious safety risks.

Macroautophagy/autophagy is a well-established homeostatic mechanism that contributes to the integrity of multiple regulatory biological activities including but not limited to the gastro-intestinal tract and cognitive integrity. Autophagy also plays a central role in tissue regeneration, metamorphosis and development whereas defects in autophagy are associated with a wide range of disorders including metabolic diseases such as diabetes, organ pathophysiologies including liver, lung and heart...

Age-related endothelial dysfunction in the cerebral microcirculation contributes significantly to the pathogenesis of vascular cognitive impairment and dementia (VCID). Time-restricted eating (TRE) has emerged as a promising lifestyle intervention with beneficial effects on metabolic and vascular health; however, the mechanisms by which TRE influences the brain microvasculature remain incompletely understood. In particular, the role of circulating factors induced by TRE in modulating endothelial...

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The longevity-linked APOE2 gene appears to protect brain cells by reducing DNA damage and helping neurons recover from stress. The finding could open a new path toward treatments that mimic APOE2’s defenses in people at higher genetic risk for Alzheimer’s.

A large study suggests that GLP-1 drugs including Ozempic and Mounjaro may slightly increase the risk of hair loss in people with type 2 diabetes. Compared with two other common classes of diabetes medications, GLP-1 users had a significantly higher rate of alopecia, though the absolute risk was still low. The hair loss was mainly non-scarring, which means it may be reversible.

A massive genetic study has identified nine new genes linked to hyperemesis gravidarum, the most severe form of pregnancy sickness, bringing the total number of known risk genes to ten. The discoveries provide fresh insight into why some women experience debilitating nausea and vomiting during pregnancy while others do not. Several of the newly identified genes are involved in appetite, nausea, metabolism, and brain function, opening the door to more targeted treatments.

A global shift toward healthier diets could sharply reduce livestock farming, free up agricultural land, and cut emissions from land-use change by 85% by 2050. At the same time, fruit, vegetable, nut, and legume production could soar, creating a sweeping transformation of what the world grows and eats.

A 25-year study found that frequent consumption of soda, sports drinks, and fruit juice beginning in childhood was linked to a higher risk of high blood pressure in adulthood. Swapping one daily drink for whole fruit, milk, or water could significantly reduce that risk.

Alzheimer's disease (AD) is a multifactorial neurodegenerative disorder lacking effective disease-modifying therapies. Astragalus membranaceus (AM) has shown potential neuroprotective effects, but its underlying mechanisms remain incompletely understood. In this study, a meta-analysis, network pharmacology, molecular simulation, and experimental validation were integrated to investigate the therapeutic potential of AM in AD. Meta-analysis of three randomized controlled trials showed that AM...

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Tendinopathy is a common condition that causes long-term pain. The inflammatory microenvironment (inflamed soil) promotes the ingrowth of sensory nerves (a key pain trigger) and induces functional impairments in tendon stem/progenitor cells (TSPCs) (dysfunctional seeds). These interconnected processes collectively drive the progression of tendinopathy, which is frequently accompanied by persistent pain. Here, we develop a multifunctional nanoplatform (MSM-DTM) by integrating macrophage-sensory...

Skeletal muscle aging is a complex biological process that involves coordinated changes in multiple cell types. Recent breakthroughs in single-cell sequencing technology have provided new perspectives regarding this process. Here, we systematically summarize current progress in single-cell technology with respect to skeletal muscle aging. We focused on specific molecular characteristics and interaction networks of muscle fiber, satellite and immune cells during aging. Aging skeletal muscles...

Tumor senescence is a durable cell-cycle arrest triggered by oncogenic signalling, DNA damage and therapeutic stress. Although senescence can restrain malignant expansion, heterogeneous senescence-associated secretory programs can also promote tumor progression, immune evasion and treatment resistance. Crucially, the composition, magnitude and persistence of these secretory programs vary across cell types, microenvironmental niches and treatment phases, making binary detection of "senescent...