Aggregator

A newly identified protein may be one of the biggest obstacles holding CAR T-cell therapy back. Researchers found that NFIL3 causes these engineered immune cells to become exhausted and lose their cancer-fighting power over time. When NFIL3 was disabled, the cells remained stronger for longer and controlled tumors more effectively in animal models.

A major study suggests that some of the groundwork for brain development may be shaped before birth through a surprising partnership between a baby’s genes and gut microbes. Researchers found that epigenetic changes present at birth can influence how the gut microbiome develops during the first year of life, and certain combinations were linked to early signs of autism and ADHD by age three.

Systemic microbial infection leading to septic shock with multiple organ dysfunction syndrome (MODS) is a major cause of mortality and represents a substantial unmet medical need. We recently observed that, compared with uninfected controls, patients with septic shock exhibit significantly elevated circulating concentrations of the tissue hormone acyl-CoA binding protein (ACBP), encoded by the diazepam binding inhibitor (DBI) gene, a potent inhibitor of autophagy. Increased plasma DBI/ACBP...

Gases released from satellites could slash the threat of severe space weather

Researchers found that social behavior begins in the brain before it becomes visible as movement. In zebrafish, a coordinated pattern of activity spread across the brain several seconds before the animals approached another fish. A higher brain region called the pallium played a key role, and fish with stronger neural signals were generally more social.

New policy hands universities the reins in probing allegations against faculty

A surprising new study suggests that when it comes to pancreatic cancer, the kind of fat you eat may matter more than how much. Researchers found that oleic acid—the main fat in olive oil and several other common foods—sped up tumor growth in mice predisposed to pancreatic cancer, while omega-3-rich fats from fish oil dramatically slowed disease development.

Allen Institute initiative aims to capture earliest cellular changes and identify new drug targets

A Salk Institute study found that a simple dietary amino acid, methionine, dramatically improved survival in mice facing severe infections and inflammatory conditions. Rather than directly targeting the immune system, methionine boosted kidney filtration, helping the body flush out excess inflammatory molecules that can cause tissue damage, brain dysfunction, wasting, and death.