Aggregator

Spanish National Research Council, established under Francisco Franco’s dictatorship, has published the stories of some 500 researchers and support staff purged after civil war

Mitochondria and inflammation are tightly linked in aging and Alzheimer's disease (AD), and recent evidence implicates mitochondrial double-stranded RNA (mt-dsRNA) as a potential trigger of inflammation. We examined mt-dsRNA accumulation and dsRNA signaling in brain aging and AD using complementary human brain tissue and in vitro transcriptomic datasets by quantifying mitochondrial transcripts, dsRNA editing, and related gene expression patterns. We found that mt-dsRNA signatures increased after...

CONCLUSION: The results of this study showed that holding group poetry reading sessions can promote meaning in life, especially in the domain of "searching for meaning" among the elderly. But results showed no significant difference between the two groups' Subjective Vitality mean scores after the intervention. Therefore, holding such classes in elderly day care centers or nursing homes are recommended to improve meaningful life in the elderly.

CONCLUSIONS: Adherence in later life reflects how older adults position themselves toward self‑care in the face of vulnerability, changing identities, and real‑world constraints. Clinical practice may benefit from linking recommendations to what matters most to patients, simplifying regimens, strengthening relational support, and addressing structural barriers. Tailoring care to patients' life contexts may foster more sustainable and meaningful engagement with treatment.

CONCLUSIONS: Immune-inflammatory and nutritional status mediate age-dependent survival disparities in older NPC patients. These findings underscore the clinical imperative of addressing inflammatory burden and nutritional depletion in geriatric oncology and advocate for integrated biomarker-guided management strategies.

Mitochondria and inflammation are tightly linked in aging and Alzheimer's disease (AD), and recent evidence implicates mitochondrial double-stranded RNA (mt-dsRNA) as a potential trigger of inflammation. We examined mt-dsRNA accumulation and dsRNA signaling in brain aging and AD using complementary human brain tissue and in vitro transcriptomic datasets by quantifying mitochondrial transcripts, dsRNA editing, and related gene expression patterns. We found that mt-dsRNA signatures increased after...

INTRODUCTION: Precise regulation of grip forces is fundamental for skilled object manipulation and independent navigation of everyday activities throughout the lifespan. Maximal grip strength is a widely used biomarker of aging and frailty, but it provides limited insight into the temporal and inhibitory control mechanisms required for dexterous prehension. Evidence suggests that grip-force release, which requires integration of sensory feedback and inhibition of sustained grip, may be...

Scientists have redesigned a key piece of MRI hardware using metamaterials, allowing existing scanners to produce clearer images of difficult-to-see parts of the body in less time. The breakthrough could improve diagnoses, make scans more comfortable, and open the door to new medical imaging and treatment applications.

A naturally occurring bacterium from amphibian intestines completely eliminated colorectal tumors in mice with a single treatment by both attacking cancer cells and activating the immune system. The findings point to a promising new type of cancer therapy that could one day work against many solid tumors.

Scientists found that a modified Mediterranean-style diet with low protein and just enough methionine helped mice live healthier lives while reducing body fat and frailty. Human data also linked lower animal protein intake to lower rates of obesity and Type 2 diabetes, suggesting the approach could benefit people as well.

Shrunken version of Archimedes screw could allow researchers to move molecules around at tiny scales

A new study debunks the long-standing claim that baby rattlesnakes are more dangerous than adults. Researchers found that young rattlesnakes can control their venom just like adults, while adult snakes usually inject much more venom and cause more serious bites. The team also uncovered how the myth spread through decades of inaccurate news reports and misleading quotes from trusted sources.

New X-Labs initiative aims to develop breakthrough technologies—but academics aren’t sure they are welcome