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Scientists have uncovered a surprising link between Alzheimer’s-related protein buildup, disrupted brain waves during deep sleep, and fading memory. The findings suggest that hidden changes in how the brain processes memories overnight may contribute to age-related memory loss long before Alzheimer’s symptoms appear.

Scientists have developed a revolutionary gel that could regrow lost tooth enamel by harnessing minerals naturally found in saliva, potentially overcoming one of dentistry’s biggest limitations. The regenerated enamel behaves much like healthy enamel, raising hopes for a simple treatment that could repair damaged teeth, prevent decay, and reduce sensitivity.

Scientists have solved a decades-old mystery and uncovered a hidden immune system defense that protects healthy cells from the very inflammation meant to fight infections. The surprising discovery could lead to new approaches for treating cancer, inflammatory bowel disease, and other conditions involving excessive inflammation.

Pharmacotherapies for obesity and type 2 diabetes are increasingly being evaluated for their effects on cognition and brain health. Evidence from preclinical models, observational cohorts, and clinical trials has intensified interest, but findings remain mixed. A central challenge is to determine whether potential cognitive effects arise from direct actions on neural circuits, indirect consequences of improved cardiometabolic health, or both. This Review examines the evidence across...

The Mexican cavefish, Astyanax mexicanus, is a powerful evolutionary model for investigating how adaptation to extreme environments reshapes vertebrate physiology. Multiple cave populations have independently evolved under subterranean conditions, acquiring traits including insulin resistance, persistent hyperglycaemia, increased adiposity, altered sleep patterns, hypoxia tolerance and extensive metabolic reprogramming. Despite these differences, cavefish exhibit lifespans comparable to those of...

In older adult gait research, "healthy" often characterizes study samples yet is typically defined by absence of disease rather than by positive characterization. This matters beyond gait, because such samples anchor reference values, mobility thresholds, and estimates of age-related decline. This scoping review examined how "healthy" is defined and operationalized in the older adult gait literature. Following PRISMA-ScR guidance, a search of Web of Science, SPORTDiscus, MEDLINE, and PubMed...

Resistant hypertension (RH) is increasingly linked to accelerated vascular aging and is particularly prevalent among older and obese individuals. Cellular senescence has emerged as a potential driver of vascular aging, but its contribution to RH remains unclear. We examined age and body mass index (BMI) in the WalkByLab cohort and assessed whether RH was associated with vascular features consistent with accelerated aging. Obesity-related transcriptomic datasets were integrated with a curated...

Pharmacotherapies for obesity and type 2 diabetes are increasingly being evaluated for their effects on cognition and brain health. Evidence from preclinical models, observational cohorts, and clinical trials has intensified interest, but findings remain mixed. A central challenge is to determine whether potential cognitive effects arise from direct actions on neural circuits, indirect consequences of improved cardiometabolic health, or both. This Review examines the evidence across...

CONCLUSION: This study shows for the first time age-related mitophagy impairment in human neurons, and confirms findings of age-related mitochondrial impairments in human neurons. By doing so, this study paves the way for more in-depth mechanistic studies that would allow for the identification of therapeutic targets for anti-aging treatment and in the context of age-associated neurodegenerative diseases.

Brain aging is associated with chronic, low-grade inflammation known as inflammaging, which is largely driven by senescent glial cells secreting pro-inflammatory factors termed as senescence-associated secretory phenotype (SASP). In humans, the release of SASP factors in the brain is linked with an increased risk for the development of neurodegenerative disorders; thus, elucidating the underlying molecular mechanisms is essential for understanding the pathophysiology of brain aging. Both NF-κB...

Construction and mining firms are rolling out devices that track workers’ fatigue. Critics say the tech could be misused by authorities

Science, Ahead of Print.

Scientists are advancing a promising new way to fight antibiotic-resistant infections by using viruses that specifically target and kill harmful bacteria. An international team has released the first coordinated guidelines for personalized phage therapy, offering a roadmap for safely bringing this experimental treatment into clinical practice. Early findings are encouraging, with one study reporting improvement in 77% of patients and the disappearance of targeted bacteria in 61%.

Largest analysis to date of the impact of humanmade sounds finds harm across a variety of ecosystems

Novel technique for cooling atomic gases could make it easier to probe Einstein’s theory of gravity

Scientists have discovered a compound that transforms a natural muscle-repair protein into a more powerful version dubbed "Super HGF," more than doubling its ability to bind to a key receptor while protecting it from age-related chemical damage. The breakthrough, supported by early mouse experiments, could eventually help combat muscle loss and preserve strength as people age.

Scientists propose that the brain’s mysterious cross-wiring, which connects each hemisphere to the opposite side of the body, may have originated more than 500 million years ago in the visual systems of ancient fish. Rather than evolving for a specific advantage, this unusual arrangement may simply be a legacy of evolution building new brain circuits on an ancient foundation.