Aggregator

A promising new treatment for knee arthritis uses tiny, dissolvable particles to block abnormal blood vessels, easing inflammation and pain without joint replacement surgery. In a study of 194 patients, 80% experienced clinically meaningful pain relief lasting at least 12 months.

A new study reveals that people draw a surprisingly sharp line between human consciousness and artificial intelligence, even when both behave identically. Researchers found that participants considered even the most responsive AI less conscious than the least responsive human. Yet when asked about "awareness" instead, people judged humans and AI much more similarly.

Scientists have discovered that the body's cellular recycling system behaves very differently during aging than previously believed, with higher activity sometimes linked to worse physical health. A small study suggests that even gentle exercise could help restore more youthful cellular recycling patterns in older adults.

A 165-million-year-old fossil has revealed an extraordinary Jurassic predator that may help explain how mammals developed one of their most important evolutionary advantages. Although only 20 inches long, Megacauda sungei was a heavyweight among early mammal relatives, swimming through ancient waterways and hunting prey with specialized teeth. Its advanced swallowing anatomy reveals an early step toward the ability to safely nurse on milk, a key development in mammalian evolution.

Obesity and diabetes are well-established risk factors for Alzheimer's disease (AD), implicating metabolic dysfunction in AD pathogenesis. Sleeve gastrectomy (SG) is among the most effective metabolic interventions available, yet its impact on AD progression remains poorly understood. We hypothesized that SG performed early in life would improve metabolic health, attenuate AD pathology, and preserve cognition in a transgenic AD mouse model. Five-week-old female 3xTg-AD mice were preconditioned...

Targeting microglia with adeno-associated viruses (AAVs) remains challenging because of inefficient transduction, off-target expression, and inconsistent payload performance. Here, we develop an integrated, Cre-independent AAV platform that combines a compact 446-bp microglia-specific regulatory element (MSRE), a high-yield AAV2/9.m capsid, microRNA-mediated neuronal de-targeting, and a microglia-tailored codon-optimization strategy. Following direct intracranial delivery, the optimized vector...

With the global aging population, age-related neurodegenerative diseases and cerebrovascular diseases have become major public health challenges. As a modifiable lifestyle strategy, dietary intervention shows significant potential in delaying brain aging and reducing the risk of neurodegenerative and cerebrovascular diseases. Caloric restriction (CR) and dietary restriction (DR), two important nutritional intervention approaches, exhibit substantial neuroprotective potential through multiple...

Chromatin structure is essential for gene regulation and genome stability, as neurons must preserve their 3D genome organization throughout life. This structure gradually deteriorates with aging and is further disrupted in neurodegenerative diseases. To investigate whether aging and neurodegeneration share early chromatin changes or diverge, we perform Hi-C on cortical neurons from adult, aged, and brain-specific SIRT6-knockout (S6-KO) mice and compare them to the previously published Hi-C data...

Type 2 diabetes (T2D) and obesity are highly prevalent among older adults and associated with increased Alzheimer's disease and related dementia (ADRD) risk, but underlying mechanisms linking T2D and obesity to cognitive impairment remain partially understood. Quantitative susceptibility mapping (QSM)-derived oxygen extraction fraction (OEF) provides a noninvasive MRI-based marker of cerebral metabolism and may capture early alterations in brain physiology. In this single-center, cross-sectional...

Due to increase in life expectancy, aged population is growing exponentially, globally which has impact on human health as well as biomedical research. Research highlighted coordination between aging and arthritis where aging is the underlying hallmark of arthritis progression. Despite knowing the route of pathogenesis regarding most prevalent joint disorders like Osteoarthritis (OA) and rheumatoid arthritis (RA); efficient curable approach is still challenging. Worldwide 7-8% populations suffer...

The increasing prevalence of obesity, type 2 diabetes, cardiovascular disease, and age-related disorders has been linked to a growing mismatch between modern lifestyles and the biological rhythms that regulate human physiology. Chrononutrition, which explores the interaction between meal timing, circadian rhythms, and metabolism, has emerged as a promising strategy to improve metabolic health and support healthy aging. This review examines the molecular and physiological foundations of...

With the global aging population, age-related neurodegenerative diseases and cerebrovascular diseases have become major public health challenges. As a modifiable lifestyle strategy, dietary intervention shows significant potential in delaying brain aging and reducing the risk of neurodegenerative and cerebrovascular diseases. Caloric restriction (CR) and dietary restriction (DR), two important nutritional intervention approaches, exhibit substantial neuroprotective potential through multiple...

Chromatin structure is essential for gene regulation and genome stability, as neurons must preserve their 3D genome organization throughout life. This structure gradually deteriorates with aging and is further disrupted in neurodegenerative diseases. To investigate whether aging and neurodegeneration share early chromatin changes or diverge, we perform Hi-C on cortical neurons from adult, aged, and brain-specific SIRT6-knockout (S6-KO) mice and compare them to the previously published Hi-C data...

As primary immune cells of the central nervous system (CNS), microglia maintain immune surveillance, inflammation regulation, cell interactions and debris clearance. These dynamic and adaptive effector functions are reciprocally sustained by microglial metabolism. Lipids are emerging as a key programmer of microglial metabolic and functional flexibility in conditions of homeostasis, cellular stress, and pathology. The delicate equilibrium in microglial lipid homeostasis is dependent on the...

Odor is a powerful contextual cue that can influence memory and is closely linked to brain regions involved in episodic memory, including the hippocampus. Age-related olfactory dysfunction is among the earliest behavioral changes associated with cognitive decline and may contribute to memory impairments in older adults. Hippocampal pattern separation, or the process of reducing interference among similar experiences, provides a sensitive measure of age-related memory decline, yet little is known...

CONCLUSION: Greater ten-year ASCVD risk was consistently associated with cognitive impairment independent of plasma AD biomarkers, with evidence that p-tau181 modifies these associations and that their magnitude varies across racial and ethnic groups.

CONCLUSIONS: Our survey results indicate that older adults preferred to seek and receive HHC through traditional medical settings. These data were collected prior to the pandemic and before some of the recent OTC policy changes; nonetheless, they align with more recent findings and capture the attitudes of individuals who are likely still making HHC decisions today. These findings, therefore, provide contextual evidence about older adults' reported preferences against which future studies of...

Testosterone levels decline progressively with age from the third decade of life, impairing spermatogenesis and contributing to age-related disorders, underscoring the importance of enhancing endogenous testosterone production. DNA methyltransferase 1 (DNMT1) promotes testosterone synthesis in Leydig cells (LCs), yet the underlying mechanism remains unclear. Here, we found that DNMT1 expression is downregulated in aging rat testes and senescent LCs in vitro, correlating with reduced testosterone...