Aggregator

Accurate diagnosis of dementia with Lewy bodies (DLB) remains challenging, with misdiagnosis potentially leading to harmful treatment decisions. DOPA decarboxylase (DDC) shows promise as a cerebrospinal fluid (CSF) biomarker for DLB and Parkinson's disease (PD), but quantitative assays are needed for its clinical implementation. Here we report on the development of two DDC immunoassays and the extensive clinical validation of DDC across three clinical cohorts (n = 740), one biologically defined...

Effective treatments for age-related chronic neurodegenerative diseases such as Alzheimer's disease remain limited, in part because the molecular drivers of cognitive decline are still not fully understood. Human genetic studies, together with detailed analysis of disease pathology, indicate that the immune system has an important influence on disease progression. Research to date has focused largely on microglia - specialized innate immune cells that reside within the central nervous system...

Understanding the development of midbrain dopaminergic (mesDA) neurons is essential for advancing cell replacement therapies for Parkinson's disease. In the developing ventral midbrain (VM), radial glia (Rgl) cells are the progenitors of mesDA neurons. However, distinct Rgl subtypes have recently been identified, and their individual roles are unclear. Here we analyze transcriptomic data from mouse and human VM Rgl to define their contributions to mesDA neuron development. We identify Rgl1 as...

Pregnancy and aging are associated with stress on the body and show multi-system physiological changes. We asked whether we can learn about aging from the changes in pregnancy. To do so, we analyzed weekly cross-sectional data on 70 lab tests from 300,000 pregnancies and 1.4 million non-pregnant females aged 20-89. Using a biological age model trained on non-pregnant females, we observed that pregnant females' apparent age dropped by 5 years in the first trimester, rose by 20 years toward...

Reducing CO(2) emissions throughout a product's life cycle, mainly encompassing four stages of raw materials extraction, processing, service, and end of life, is essential for carbon neutrality. Passive daytime radiative cooling coatings offer CO(2) reduction benefits, but primarily only during service stage. Life cycle assessment demonstrates maximized full life-cycle CO(2) reduction requires innovations in both raw materials extraction and service periods. Here, we develop a full life‑cycle...

CONCLUSION: The findings indicate that active engagement in social activities, encompassing community, cognitive, home-based creative, and physical activities, is associated with slower EAA, marked by several clocks in older adults, providing evidence for the benefit of social activities for health and offering valuable insights for promoting "Active Aging" initiatives.

CONCLUSION: The global number of people living with dementia nearly tripled from 1990 to 2021, mainly due to increases in population ageing and growth. The findings emphasize the need for comprehensive strategies to address ADOD, including prevention, early diagnosis, and effective management, with a focus on gender and regional disparities.

[This corrects the article DOI: 10.3389/fnagi.2025.1613566.].

CONCLUSION: The global ADOD burden is escalating with pronounced dynamic heterogeneity in growth velocity and distinct spatial patterns. Our multi-model projections warn of a mounting crisis, disproportionately impacting women, the oldest-old, and rapidly aging middle-income regions. Public health strategies must evolve from static assessments to dynamic surveillance and geographically tailored interventions, with urgent investment in prevention and care systems in high-growth clusters.

Inoculating soil with pink microbes could help reduce the use of toxic insecticides.

Idebenone (IDE), an analog of ubiquinone, has demonstrated therapeutic potential across various neurodegenerative disorders. Clinically, IDE has been shown to exert neuroprotective effects in Parkinson's disease (PD), being capable of alleviating motor symptoms as well as reducing depressive and anxious moods. However, the mechanism of action of IDE in PD has not been fully elucidated. Thus, the present study aims to investigate the potential effects of IDE on...