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CONCLUSIONS: A higher cognitive reserve is linked to a decreased risk of developing frailty, slower progression, and a greater likelihood of improvement from pre-frailty to non-frailty, suggesting that lifelong cognitive enrichment enhances the physiological reserve beyond cognition. These findings suggest that interventions and policies that support the development of cognitive reserve across the life course may contribute to healthier frailty trajectories in later life.

CONCLUSIONS: Sleep quality and frailty are associated with CMM, suggesting that their combined assessment may enhance predictive accuracy for CMM risk. These findings underscore the need to prioritize high-risk elderly individuals for integrated interventions addressing sleep disturbances and frailty, thereby facilitating the transition from reactive to proactive cardiometabolic care models.

A large laboratory study found that many commonly used sweeteners can directly change the growth of gut bacteria. Researchers identified more than 100 cases in which sweeteners behaved differently when combined with medications, caffeine, or flavorings. The combination of isosteviol and the antidepressant duloxetine was especially disruptive, reducing beneficial bacteria and overall microbial diversity.

Youlin Chen analyzed earthquake data that can also aid nuclear-test monitoring

A drug originally developed for spinal cord injury may offer a fresh approach to treating Alzheimer’s disease. In mouse studies, KCL-286 repaired dangerous DNA damage, reduced inflammation, and targeted multiple disease-related pathways instead of focusing on just amyloid or tau. Since it has already cleared an initial human safety trial, researchers believe it could move more quickly into Alzheimer’s clinical testing.

Some countries face reductions of more than 90%, new report reveals, raising fears of devastating impacts on global health and education

A new experimental treatment may have found a way to outsmart glioblastoma’s toughest defense: the blood-brain barrier. Researchers used sugar-coated nanoparticles to ferry genetic instructions that restore a key tumor-suppressing protein directly into brain cancer cells. In mouse studies, the therapy increased median survival by 50% while shrinking tumors without noticeable damage to other organs.

Staffers complain that Salk allowed circadian rhythms researcher Satchidananda Panda to depart quietly, while the allegations and findings remain under wraps

An international study found that finerenone slows kidney function decline and reduces the risk of serious kidney and cardiovascular complications in people with chronic kidney disease who do not have diabetes. The results could open the door to a much-needed new treatment option for the majority of CKD patients who have long had limited choices.

Ancient Teghaza meteorite hints at granitelike crust and shows Mars was already losing its water 4.1 billion years ago

Finding points to potential way to break apart dangerous biofilms without antibiotics

National Academies report says the fast-growing field can boost confidence with more rigorous results

The extent to which the cerebrovasculature is affected in various brain disorders is still not well understood. To address this, we established a transcriptomic repository of major vascular cell types and microglia to compare the global transcriptomic response in mouse models of three human brain disorders linked to neuroinflammation and associated vascular reactivity: Alzheimer's disease (AD), traumatic brain injury (TBI), and cerebral autosomal dominant arteriopathy with subcortical infarcts...