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Enhancing the performance and interpretability of epigenetic clocks
Epigenetic clocks based on DNA methylation (DNAm) accurately predict age, but their biological underpinnings remain unclear. One primary mechanism by which DNAm might influence gene regulation is by modulating transcription factor binding activity. This study investigates the regulatory potential of predictive CpGs in established epigenetic clocks. Our analysis reveals that generally most CpGs used by epigenetic clocks do not overlap known transcription factor binding sites (TFBS), indicating...
Endosymbiotic theory of aging revisited: Age-related leakage of mitochondrial dsDNA/RNA stimulates cytosolic nucleic acid sensors which remodel the immune network and promote the aging process
About 1.5-2 billion years ago, an endosymbiosis between aerobic α-proteobacteria and anaerobic archaeal cells generated mitochondria, i.e., organelles capable of producing oxidative energy. The bacterial genome was fundamentally reduced and a circular mitochondrial genome evolved containing mainly the genes coding for the subunits of the electron transport chain. Before the symbiotic event, there existed a virus-host co-evolution which involved the development of sensors for detecting dangerous...
An Essential Role for Senescent Cells in Optimal Wound Healing through Secretion of PDGF-AA
No abstract
Comparison of hip abduction range of motion and strength and ankle dorsiflexion in older adults with and without a history of falls
CONCLUSION: Concurrent weakness in the hip abductors and ankle dorsiflexors may be associated with an increased risk of falls in older adults. Combined assessment of muscle strength and range of motion in these regions may assist in identifying older adults with characteristics associated with fall history.
British ‘First Fleet’ brought smallpox to Australia—and may have killed millions
Two papers pin the deadly disease’s introduction on British colonists and suggest the continent held far more people than previously believed
Body-plan organizer in comb jellies hints at animal ancestry
‘Humanizer’ tool can erase signs of AI-written text — alarming scientists
Say hello to hard helium
How to avoid dementia — what the science really says
Keep the Hubble and James Webb Space Telescopes alive — the science is worth the price tag
Save Hubble: the race to preserve the space telescope kicks off
How to widen access to the critical minerals that the world needs
How long can humans live? All evidence points to a maximum of 125 years
AI can cause harm: safeguards must catch up
Listen to Gen Z when it comes to AI in education
Publisher Correction: A 98-qubit trapped-ion quantum computer with all-to-all connectivity
Scientists discover why exercise reverses muscle aging
Researchers have uncovered a molecular “switch” that helps explain why exercise keeps ageing muscles healthy. By reducing levels of a gene called DEAF1, physical activity allows older muscles to clear out damage, repair themselves, and maintain strength.
Scientists solve a 30-year rye pollen mystery that could transform cancer research
Scientists have finally solved a nearly 30-year-old mystery surrounding two unusual molecules found in rye pollen that once showed an intriguing ability to help animals fight tumors. By determining their exact 3D structures, researchers have unlocked the blueprint needed to investigate how these natural compounds interact with the immune system and which parts may be responsible for their cancer-fighting effects.
Scientists want to quarantine alien life on the Moon before it reaches Earth
Scientists are calling for a lunar quarantine facility where samples from Mars, the Moon, and beyond would be examined before being brought to Earth. They warn that even a tiny alien microorganism could have unpredictable effects on Earth's ecosystems. By using robotic handling systems on the Moon, researchers hope to eliminate the risk of accidental exposure or release.
Glycosylation in Alzheimer's disease
No abstract