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Scientists find a natural gut compound that helps heal the intestine
A natural compound produced by gut bacteria after digesting foods such as pomegranates, walnuts, and berries may help repair and protect the intestinal lining. The discovery reveals a surprising beneficial side of an inflammatory pathway and could inspire more targeted treatments for Crohn’s disease and ulcerative colitis.
Textbooks may have misdrawn this basic brain structure for 100 years
Scientists discovered that brain-cell axons may not be smooth tubes as textbooks have shown for more than a century, but instead naturally resemble strings of tiny pearls. Those pearl-like structures can change with neural activity and may help control how quickly electrical signals travel through the brain.
Life Course Neighborhood Socioeconomic Disadvantage and Chronic Disease Accumulation in Mid- to Late Adulthood
ObjectiveThis study examines associations between neighborhood socioeconomic disadvantage during adolescence and early adulthood and chronic disease accumulation in mid- to late life.MethodsUsing Panel Study of Income Dynamics data linked to U.S. Census and American Community Survey data, we identify four trajectories of neighborhood disadvantage, namely persistent disadvantage, increasing disadvantage, decreasing disadvantage, and persistent advantage, and estimate their associations with...
Take a risk or play it safe? Neuronal tug-of-war helps the brain decide
Exclusive: New evidence for hidden chambers beyond Tutankhamun’s tomb
Schoolhouse meals serve up an income bump
Author Correction: Genomic deletion of malic enzyme 2 confers collateral lethality in pancreatic cancer
Who gets credit in the AI era? OpenAI maths bombshell sparks debate
New mesothelioma drug turns cancer’s own defenses against it
Scientists are testing a counterintuitive way to fight mesothelioma, an aggressive asbestos-linked cancer with few effective treatments. A new experimental mesothelioma drug kills cancer cells by disabling PRX3, an antioxidant defense that tumors use to survive intense oxidative stress. In an early clinical trial, it controlled disease progression in 67% of patients and produced encouraging survival results, raising hopes that the strategy could eventually be used against other cancers.
Scientists find a hidden health advantage in black and green rice
Scientists found that black and green Japanese rice contain unusual, potentially beneficial fats and may be digested more slowly than ordinary white rice. The combination could make these colorful varieties promising ingredients for foods designed to support blood sugar and metabolic health.
Hidden “immune organ” in the skull may help fight brain cancer
Scientists discovered a hidden “immune organ” inside the skull that acts as a rapid first responder against brain cancer in mice. Strengthening this local immune defense improved tumor rejection and survival, raising the possibility of new treatments that target the skull directly.
Scientists find an immune “false alarm” that may drive rapid aging
Scientists have discovered that some severe genetic disorders linked to rapid aging may be driven not just by damaged DNA, but by the body’s overreaction to that damage. When broken DNA fragments leak into the wrong part of a cell, an immune sensor called cGAS can mistake them for signs of a viral infection, triggering chronic inflammation and even interfering with DNA repair itself.
Scientists find the whole grain “sweet spot” for better heart health
Eating four to six servings of whole grains a day may deliver meaningful benefits for heart health, according to a large review of 87 clinical trials. Researchers found improvements in body weight, waist size, blood pressure, cholesterol, blood sugar, triglycerides, and some markers of inflammation.
Scientists recreated what mice saw from brain activity alone
Scientists reconstructed videos from the brain activity of mice, producing 10-second clips based only on signals from neurons in the visual cortex. The breakthrough could help reveal how the brain reshapes what we see before it becomes our perception of reality.
Human neurons flourish in mouse brains, offering a new view of neurodevelopmental disorders
Method of replacing much of the mouse cortex with human “organoids” enables studies of brain diseases in a living nervous system
Associations of physical fitness with brain structure, pathology and cognition in cognitively normal older adults
The role of physical fitness in cognitive reserve and brain maintenance remains unclear. We investigated the associations of muscular and aerobic fitness (VO(2)max) with markers of brain health and cognition in 353 cognitively unimpaired older adults (mean age = 72.77 ± 7.95 years; 177 females). Muscular fitness comprised handgrip strength, appendicular skeletal muscle mass, and Timed-Up-and-Go performance. Blood biomarkers of Alzheimer's pathology (Aβ(1-42)/Aβ(1-40), p-tau(217), GFAP) and...
APOE genotypes differentially remodel the astrocytic lipid droplet proteome to shape lipid droplet dynamics
Lipid droplets are dynamic cellular organelles that store neutral lipids and coordinate metabolic and stress-response pathways. In the brain, lipid droplets in glial cells, including astrocytes, have been implicated in Alzheimer's disease, but how genetic risk factors influence their composition and turnover remains poorly understood. APOE is the strongest genetic modulator of late-onset Alzheimer's disease and exists in common variants that confer decreased, neutral, or increased risk. Here we...
Map of brain 'microproteins' could offer new clues to Alzheimer's disease
No abstract
Sex-specific biological aging clocks across organs and omics
Sex differentially shapes aging, neurodevelopment and neurodegenerative diseases such as Alzheimer's disease (AD). However, most biological aging clocks (artificial intelligence-predicted age minus chronological age) were trained on sex-pooled samples and implicitly assume sex invariance.Here we developed 38 sex-specific biological aging clocks across 15 organ systems. We first demonstrate the importance of sex-stratified training for constructing sex-specific healthy normative references and...
HMGA1-HP1beta axis regulates premature aging in Hutchinson-Gilford progeria syndrome through chromatin remodeling
Hutchinson‑Gilford progeria syndrome (HGPS) is a rare premature aging disorder caused by mutations in the LMNA gene. High mobility group A1 (HMGA1) exhibits differential expression patterns across aging models. However, its roles and mechanisms in aging remain unclear. Here, we show a positive correlation between HMGA1 and the heterochromatin protein HP1β in multiple tissues of Lmna^(G609G/G609G), a classic genetic mouse model of HGPS to recapitulate typical premature aging features, and...