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A single dose reversed autism-like symptoms in adult mice within hours

14 hours 56 minutes ago
Even mild inflammation during pregnancy led mouse offspring to develop persistent brain overactivity, sensory sensitivity, repetitive behaviors, and increased seizure risk. Remarkably, one dose of rapamycin improved nearly all of these problems within about two hours. The benefits were temporary, but they suggest that adult brain circuits may remain far more adaptable than previously believed.

Coffee may help shield the liver from fat, scarring, and cancer

17 hours 39 minutes ago
A major long-term study linked coffee consumption with lower risks of cirrhosis, liver cancer, and death from liver disease. Coffee drinkers also showed healthier liver scans and blood protein patterns, with less fat, inflammation, and scarring. Benefits appeared even at one or two cups daily and were strongest around three to four cups.

Targeting the NLRP3 Inflammasome in Alzheimer's Disease: Mechanistic Insights and Therapeutic Advances

20 hours 6 minutes ago
Alzheimer's disease (AD) is the leading cause of dementia, yet current therapies provide limited clinical benefit. Neuroinflammation, as an early and sustained driver of AD, places the NLRP3 inflammasome at the center of pathological and therapeutic focus. In this review, we synthesize recent advances in the structure, assembly, and activation of the NLRP3 inflammasome, and evaluate its contribution to AD using evidence from human brain tissues, cerebrospinal fluid, and diverse AD animal models....
Wenwen Lian

Transcriptomic landscape of human cardiac aging: identification of cardioselective age-associated genes and predictive modeling

20 hours 6 minutes ago
Age is a major risk factor for cardiovascular disease, yet the molecular mechanisms underlying human cardiac aging are not fully understood. Using bulk RNA sequencing data from the Genotype-Tissue Expression (GTEx) project, we identified cardiac age-associated genes by intersecting transcripts significantly correlated with age in both the atrial appendage and left ventricle, while excluding those similarly altered in skeletal muscle. Among these, 131 genes were positively correlated with age,...
Sheena Yi-Hsin Cheng

Non-apoptotic role of caspase enzymes in satellite cells from human skeletal muscle

20 hours 6 minutes ago
Satellite cells (SCs) are essential for skeletal muscle regeneration, but their function declines with aging, often associated with increased pro-apoptotic signaling. This study investigated the impact of in vitro serum starvation-as a model of acute microenvironmental and nutrient stress-on the apoptosis and differentiation potential of human SCs from young and aged donors. SCs were isolated from the Vastus Lateralis of young and aged subjects and cultured in serum-free medium for up to 72 h....
Roberta Di Pietro

Genetic predisposition to longer lifespan, lifestyle factors, and all-cause mortality: a 17-year prospective cohort study

20 hours 6 minutes ago
We examined whether a genome-wide polygenic lifespan score (PLS) is associated with all-cause mortality and how this association compares with associations between long-term lifestyle factors and mortality. The PLS was computed for the older Finnish Twin Cohort (mean age 57.4 years; 45.2% men; N = 5575). Cox regression was used to estimate the effects of the PLS on all-cause mortality risk, before and after adding sex, physical activity, BMI, alcohol consumption, smoking behavior, and education...
Niko P Tynkkynen

Beyond the linear genome: how reference bias threatens preventive medicine and geroscience

20 hours 6 minutes ago
Genotype-first screening compares patient genomes to a standard reference. The GRCh38 linear assembly contains reference minor alleles (RMAs), posing a critical structural vulnerability for automated clinical variant classification. To determine whether RMAs systematically generate false-positive annotations, we conducted an observational case series of 20 healthy adults undergoing preventive genome sequencing. Automated bioinformatic processing was performed using the GRCh38 linear reference to...
Gyula Richárd Nagy

Action simulation as an intervention to improve balance, mobility and gait in healthy older adults: A scoping review

20 hours 6 minutes ago
Falls in older adults are a significant public health concern. Action simulation interventions involving action observation and/or motor imagery have been proposed as alternative or adjunct strategies to physical exercise for reducing fall risk. These approaches may minimize barriers to physical practice and may specifically target deficits in motor planning that are linked to falls. The purpose of this scoping review is to examine how action simulation interventions have been applied and...
Neza Grilc

A new antiviral could stop measles before an outbreak takes off

1 day 16 hours ago
An experimental pill prevented a measles-like virus from spreading through the air or through close contact in ferrets. It worked when given shortly before or after exposure and also shortened illness and the period when infected animals remained contagious. Researchers say the drug could one day complement vaccination and make outbreaks easier to contain.

Dissecting divergent outcomes in stem cell-derived dopamine cell therapy trials for Parkinson's disease

1 day 20 hours ago
Fetal tissue transplantation established proof-of-concept for dopamine cell replacement in Parkinson's disease but yielded inconsistent outcomes due to limited tissue availability and cellular heterogeneity. Advances in generating high-purity dopamine progenitors from pluripotent stem cells have enabled standardized products that show safety and motor improvement in clinical trials. However, these trials revealed divergent outcomes arising at three levels: between clinical studies, driven by...
Chan Wook Park