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We present CIT-Lasso, a framework that uses only summary statistics to identify, genome-wide, sets of variants carrying non-redundant information on a phenotype, distinguishing likely causal variants from correlated variants that are merely associated. The open-source implementation completes genome-wide analysis in under 15 min on one CPU. In simulations, it outperforms existing methods in false discovery rate control, power, and fine-mapping resolution. Applied to an Alzheimer's disease...

Age-associated thymic involution leads to a reduction of T-cell production, which constitutes a primary factor in immunosenescence, thereby increasing vulnerability to cancer, infections, and autoimmune disorders. Thymic epithelial cells (TECs), essential for T-cell development, exhibit progressive senescence with aging. The development of strategies to mitigate TECs senescence and delay thymic degeneration has emerged as a significant research focus. Here, aged C57BL/6J mice and immortalized...

A newly discovered network of fine hairs and specialized nerve cells appears to form a dedicated system for sensing mechanical itch, offering fresh insight into why chronic itching occurs. Because humans show signs of having the same pathway, the research could pave the way for more effective treatments for conditions such as eczema.

Researchers have discovered that the retina uses an unexpected communication network that lets separate visual pathways cooperate instead of working alone. A newly identified "commander" cell appears to coordinate this system, helping the eye detect faint details that might otherwise be missed.

Exercise doesn't just make the heart stronger. It also rewires the nerves that regulate it, a discovery that could pave the way for more personalized treatments for common heart conditions such as arrhythmias and angina.

Sleeping about an hour and 20 minutes less each night for six weeks caused participants to gain weight and spend more time inactive. Researchers found that even mild, realistic sleep loss, similar to what many adults experience, had measurable effects. They warn that if this pattern continues over months or years, the health consequences could become much more significant, including a higher risk of diabetes and heart disease.

Scientists point to changes that jeopardize the marine mammals’ critical feeding grounds