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Analysis of gravitational waves supports theory that some stars explode without leaving behind black holes

Bristling, multilegged ocean swimmer shows early emergence of claws  

Ambitious effort tested whether more than 100 papers held up on multiple types of “repeatability” tests

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CONCLUSIONS: Community-based interventions to improve physical accessibility and dementia awareness may be important avenues for supporting social activity engagement among people in the last stage of life, particularly among older adults living independently in their communities.

Aging is accompanied by progressive functional decline, and nuclear receptors have become significant modulators of the process. Farnesoid X receptor (FXR), a ligand activated nuclear receptor transcription factor that regulates genes involved in bile acid and metabolic homeostasis, has been implicated in aging, yet genetic evidence remains limited. In this study, we demonstrate that FXR knockout (FXR^(-/-)) mice have significantly shorter lifespan and healthspan than WT mice. FXR deficiency led...

Mitochondrial degeneration and dysfunctions are increasingly linked with neurodegenerative diseases, with the greatest risk factor being increased age. Mitochondrial dysfunction is also implicated in sarcopenia, the age-associated weakness and atrophy of striated muscle. Untangling the pathophysiological effects of age-related mitochondrial degeneration and dysfunction is of huge interest in gerontology. In elderly humans and Fischer 344 (F344) rats, motor neuron (MN) death and denervation...

Older adults often exhibit reduced inhibitory control accompanied by altered recruitment of prefrontal networks. Whether the emotional context changes these age-related neural patterns during response inhibition remains unclear. In this study, 31 older adults and 19 young adults completed four blocks of a Go/No-Go paradigm while bilateral prefrontal cortex (PFC) activity was recorded using functional near-infrared spectroscopy (fNIRS). Blocks 1 and 2 comprised a neutral (non-emotional) Go/No-Go...

Frailty reflects an accumulation of health deficits across multiple physiological systems. Better physical function is associated with higher executive function, but it remains unclear if frailty influences this relation. This study tested if the association between physical performance and executive function in older adults would be stronger among frailer persons. It also sought if cerebral oxygenation is associated with these factors. Sixty older adults (72 ± 6 years; n = 11 male) were divided...

Ageism refers to stereotypes, prejudice, and discrimination based on age. Ageism negatively impacts physical and mental health across the lifespan, yet knowledge about the experience of ageism in Singapore is limited. This study evaluated the prevalence of experienced ageism in Singapore and identified its key determinants within a nationally representative cohort. In the cross-sectional HEalthy LOngevity (HELO) survey (N = 3034), ageism was measured using the newly launched World Health...

Neuromuscular function is critical for independence in ageing, yet asymmetries between dominant and non-dominant limbs, arising from central or peripheral mechanisms, are not well understood. This study examined age- and limb-related differences and motor unit (MU) firing behaviour of the vastus lateralis under tasks of varying difficulty. Twenty-one young (22 ± 4 years; 15 M, 6F) and seventeen older adults (74 ± 5 years; 12 M, 5F) performed constant and variable force unilateral isometric knee...

Global understanding of arterial aging remains limited despite its well-recognized medical and economic impact, hindering the development of effective mitigation strategies. The aorta, the major elastic artery, experiences a loss of homeostasis during aging that results from highly complex interactions. A promising approach to unravel the underlaying mechanisms is to investigate how aging affects the aortic transcriptome, leveraging the tremendous technological advances in RNA sequencing...

CONCLUSION: Combining aerobic exercise with cognitive training improves clinical outcomes in older adults with MCI and may influence stress-related neurobiological pathways. This multimodal approach represents a promising, non-pharmacological strategy for mitigating age-related cognitive decline.

CONCLUSION: Liver fat accumulation and fibro-inflammation were associated with higher brain-PAD, with fibro-inflammation playing a key role. These associations may be attenuated in individuals with optimal lifestyle behaviors, suggesting a potentially modifiable target for intervention.

CONCLUSION: Socioeconomic disadvantages, reflected in lower education, income, and employment, were associated with a higher incidence of depressive symptoms. Addressing these inequalities within integrated chronic disease and mental-health care may help prevent late-life depression.

More than 60 countries are off track to meet U.N. target for 2030—even though solutions exist