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A low-fat vegan diet may help people lose weight without counting calories, shrinking portions, or feeling constantly hungry. In a 16-week clinical trial, people eating mostly fruits, vegetables, grains, and legumes consumed about 357 fewer calories per day even though the total amount of food they ate barely changed.

Researchers have uncovered a surprising way triple-negative breast cancer may turn the body against itself. Tumors appear to recruit macrophages—immune cells normally involved in healing and fighting infection—and use them to release a protein called BDNF that draws nerves into the tumor. Those nerves may then help the cancer grow, resist treatment, and potentially spread.

Cell therapies represent a promising frontier in modern medicine. Mesenchymal stromal cells (MSCs) constitute a valuable source due to their minimal ethical concerns, low immunogenicity, negligible tumorigenicity in vivo, and robust paracrine activity mediated by the secretion of anti-inflammatory and angiogenic factors. Despite these advantages, MSCs undergo rapid replicative senescence accompanied by a progressive loss of stemness markers and functional potency. In this context, cellular...

CONCLUSIONS: Better cognitive function was associated with higher objective financial literacy, whereas subjective financial literacy showed no association with cognitive performance. These findings highlight the importance of cognitive function for financial literacy in later midlife to early older age adults.

Ischemic postconditioning (I/Post), which is an effective intervention by activating endogenous cardioprotective pathways, recovers ischemia/reperfusion injury. However, this intervention is not as effective in older patients, and its mechanism needs to be further investigated. In this study, we found that myocardial telomeric repeat binding factor 2 (TRF2) protein expression in male aged mice (18 months of age) was lower than that in male adult mice (4 months of age). After ligation of the...

Adipose tissue senescence is increasingly recognized as a key driver of systemic aging and age-related functional decline, yet the endocrine regulators that actively promote this process remain poorly defined. Angiopoietin-like protein 8 (ANGPTL8) is a metabolic factor implicated in lipid metabolism and inflammation and has been associated with multiple aging-related disorders. However, its direct role in adipose tissue senescence and organismal aging remains unclear. Here, we identify ANGPTL8...

An eight-year Finnish study found that children who spent more time on screens tended to show better cognitive processing as teenagers, challenging common assumptions about screen use. Researchers say the key may be balancing physical activity with screen activities that encourage learning, creativity, and active thinking.

An experimental Alzheimer’s compound prevented damaging protein clumps from forming in the brains of mice, helping nerve cells survive longer and reducing amyloid buildup. The treatment also appeared to improve heart health and slow some signs of aging, raising hopes for an entirely new way to combat dementia.

A centuries-old heart drug costing less than ten cents a day could help keep heart-failure patients out of the hospital. New research suggests low-dose digoxin can reduce heart-failure hospitalizations by about 25%, potentially paving the way for its return as a major treatment.

Exercise and healthy blood sugar levels in midlife may help slow cognitive decline decades later. Physical activity appeared especially beneficial for Mexican American adults, suggesting that some brain-protective factors may differ across populations.

Aging gradually wears down the cartilage and fluid that protect our joints, but avoiding movement may actually make matters worse. Exercise helps nourish cartilage, strengthens the muscles that protect joints, and can reduce osteoarthritis pain. Low-impact activities such as swimming, cycling, tai chi, yoga, and walking on varied terrain may also improve balance and mobility. Even a few minutes of the right kind of movement can make a difference.

The nature of aging remains debated: is it the accumulation of damage or by execution of a program? Here, we revisit this long-standing dichotomy in light of recent experimental advances, each one of us supporting one of those paradigms and being critical about the other. The damage-driven model views aging as the progressive loss of function caused by imperfect repair and modulated by factors such as rate of damage accumulation, damage resistance, biological redundancy, and tissue regeneration....