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Enhancing the performance and interpretability of epigenetic clocks

10 hours 10 minutes ago
Epigenetic clocks based on DNA methylation (DNAm) accurately predict age, but their biological underpinnings remain unclear. One primary mechanism by which DNAm might influence gene regulation is by modulating transcription factor binding activity. This study investigates the regulatory potential of predictive CpGs in established epigenetic clocks. Our analysis reveals that generally most CpGs used by epigenetic clocks do not overlap known transcription factor binding sites (TFBS), indicating...
Tushar Patel

Endosymbiotic theory of aging revisited: Age-related leakage of mitochondrial dsDNA/RNA stimulates cytosolic nucleic acid sensors which remodel the immune network and promote the aging process

10 hours 10 minutes ago
About 1.5-2 billion years ago, an endosymbiosis between aerobic α-proteobacteria and anaerobic archaeal cells generated mitochondria, i.e., organelles capable of producing oxidative energy. The bacterial genome was fundamentally reduced and a circular mitochondrial genome evolved containing mainly the genes coding for the subunits of the electron transport chain. Before the symbiotic event, there existed a virus-host co-evolution which involved the development of sensors for detecting dangerous...
Antero Salminen

Comparison of hip abduction range of motion and strength and ankle dorsiflexion in older adults with and without a history of falls

10 hours 10 minutes ago
CONCLUSION: Concurrent weakness in the hip abductors and ankle dorsiflexors may be associated with an increased risk of falls in older adults. Combined assessment of muscle strength and range of motion in these regions may assist in identifying older adults with characteristics associated with fall history.
Zainul Abedin Alaa Naji Al-Sayyid Salman

Scientists solve a 30-year rye pollen mystery that could transform cancer research

1 day 3 hours ago
Scientists have finally solved a nearly 30-year-old mystery surrounding two unusual molecules found in rye pollen that once showed an intriguing ability to help animals fight tumors. By determining their exact 3D structures, researchers have unlocked the blueprint needed to investigate how these natural compounds interact with the immune system and which parts may be responsible for their cancer-fighting effects.

Scientists want to quarantine alien life on the Moon before it reaches Earth

1 day 5 hours ago
Scientists are calling for a lunar quarantine facility where samples from Mars, the Moon, and beyond would be examined before being brought to Earth. They warn that even a tiny alien microorganism could have unpredictable effects on Earth's ecosystems. By using robotic handling systems on the Moon, researchers hope to eliminate the risk of accidental exposure or release.