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Identification of distinct and shared biomarker panels in different manifestations of cerebral small-vessel disease through proteomic profiling
Senescence at the crossroads of postpartum remodeling and tumorigenesis
Scientists must step up to avert a nuclear breakout
China is waging war on Alzheimer’s. What can its approach teach the rest of the world?
Nuclear weapons testing is harmful — there’s no case for a restart
COVID’s origins: what we do and don’t know
Evidence alone won’t save biodiversity: the golden apple snail reveals an implementation gap
Account for AI in the environmental footprint of scientific publishing
Defunding Chile’s climate research will undermine science and the region
Treasures of scientific history could be hiding in plain sight
The Contributor Role Taxonomy tool must serve to record extent of authorship
Author Correction: Global subsidence of river deltas
Could dewdrops explain why plants are flowering earlier?
Water droplets set off a chemical cascade that tells a plant it’s time to blossom, new study finds
Allegations of a Chinese nuclear blast may reignite weapons testing
As new global arms race looms, accusation highlights limits to monitoring low-yield tests
Gene therapy targeting synaptopathy linked with Alzheimer's and Parkinson's disease
Synaptic Plasticity pertains to the synapse's tendency to adapt fresh information and is a crucial step in the establishment of brain circuits that aid in memory formation. It has become one of the most intensively researched topics in all of neuroscience. Pieces of evidence are accumulating that synaptopathy (altered synaptic plasticity) mechanisms contribute to Alzheimer's disease (AD) and Parkinson's disease (PD). Toxins responsible for synaptopathy and aberrant neurotransmitter (NT) release...
How cytochrome P450 enzymes in humans are involved in Parkinson's disease: a literature review
This review synthesizes three decades of evidence regarding the role of cytochrome P450 enzymes (CYPs) in Parkinson's disease (PD), revealing their multifaceted roles beyond traditional pesticide metabolism. While CYP2D6 remains the most studied enzyme due to its association with PD risk in poor metabolizer phenotypes and its dual role in dopamine (DA) synthesis (directly via tyramine hydroxylation and indirectly through precursor demethylation), recent research has highlighted less-studied CYPs...
Correction to "Spatial Reorganization of Chromatin Architecture Shapes the Expression Phenotype of Therapy-Induced Senescent Cells"
No abstract
S-nitrosoglutathione reductase GSNOR drives age-related obesity by promoting adipose tissue whitening through de-nitrosation of Beclin-1
Age-related obesity is a growing public health concern linked to various metabolic disorders, yet its underlying mechanisms remain incompletely understood. Here we report that S-nitrosoglutathione reductase (GSNOR), a pivotal denitrosation enzyme, increases in adipose tissue of both male mice and humans from middle-age. GSNOR knockout protects against age-related weight gain and enhances metabolism, whereas adipose-specific GSNOR knock-in mice promotes obesity and metabolic decline. Further...
Editorial Expression of Concern: The flavonoid procyanidin C1 has senotherapeutic activity and increases lifespan in mice
No abstract
Attenuating age-related decline in dendritic cell migration improves vaccine efficacy via gut-immune crosstalk
Aging impairs immune function and reduces vaccine efficacy, but whether dendritic cells (DCs), which play a central role in initiating immune responses via antigen presentation, contribute to this decline remains unclear. Through single-cell RNA sequencing analysis of lymph node changes upon vaccination in young versus aged mice, here we identify defects in DC migration during aging, alongside a dysfunction-associated gene signature in migratory DCs, and implicate these defects in the diminished...