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This diet may slow brain aging by 2.5 years

7 hours 8 minutes ago
People who followed the MIND diet more closely showed slower brain shrinkage and less grey matter loss over time, with the strongest differences equivalent to about 2.5 years of delayed brain aging. Berries and poultry were linked with healthier brain changes, while sweets and fried fast foods were associated with greater tissue loss.

1 in 13 adults under 30 already had hidden artery plaque

7 hours 49 minutes ago
More than half of 16,000 apparently healthy adults had signs of atherosclerosis, with arterial plaques already detectable in about 1 in 13 people ages 18 to 29. Researchers say directly imaging the arteries could reveal hidden cardiovascular disease years or even decades before symptoms appear.

Alzheimer’s risk gene APOE4 may have a reversible weakness

14 hours 50 minutes ago
The Alzheimer’s risk gene APOE4 may actively damage brain blood vessels and sabotage the cellular systems that remove harmful proteins. Researchers were able to reverse some of these effects in experiments, revealing promising new targets for Alzheimer’s, Parkinson’s, and other neurodegenerative diseases.

Mulberry may reshape gut bacteria and influence metabolism

1 day 7 hours ago
Mulberry compounds may reshape the gut microbiome in ways that support intestinal health and metabolism, with some combinations showing especially strong effects in animal studies. However, the results vary depending on the plant part and processing method, and the benefits have yet to be confirmed in humans.

The default mode network exhibits circuit-specific selective vulnerability despite widespread amyloid burden in an animal model of Alzheimer's disease

1 day 9 hours ago
In Alzheimer's Disease (AD) the default mode network (DMN) exhibits selective vulnerability to functional decline and amyloid beta (Aβ) plaques in early AD. DMN vulnerability may simply be the result of Aβ accumulation. Alternately, Aβ may unmask an intrinsic susceptibility of DMN circuits. Should DMN vulnerability persist amidst global Aβ deposition, this would support the latter hypothesis. We tested this using long-term, multi-region recordings of single units in mice characterized by...
Samuel J Brunwasser