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China now tops the U.S. in R&D spending by one key measure
China reached long expected milestone in 2024
Extracellular vesicle-mediated release of bis(monoacylglycerol)phosphate is regulated by LRRK2 and glucocerebrosidase activity
The endolysosomal phospholipid bis(monoacylglycerol)phosphate (BMP) is aberrantly elevated in urine from Parkinson's patients carrying mutations in leucine-rich repeat kinase 2 (LRRK2) and glucocerebrosidase (GCase). Because BMP resides on, and regulates biogenesis of, endolysosomal intralumenal membranes that become extracellular vesicles (EVs) upon release, we hypothesized that increased urinary BMP reflects enhanced exocytosis of BMP-enriched EVs. We analyzed BMP metabolism and EV-associated...
Adenosine signals an imbalance between activity and supply in privileged cells
Extracellular adenosine (e-Ado) is a critical signaling molecule, yet its origin beyond energy stress and inflammation is underexplored. Herein, we propose that Ado is ubiquitously generated in the S-adenosylmethionine transmethylation pathway and integrate this source with the concept of cellular privilege in nutrient acquisition. In this model, less privileged cells convert Ado to adenosine monophosphate (AMP) under nutrient scarcity, activating AMP-activated protein kinase, while privileged...
Memory T cell aging and rejuvenation
Aging reshapes T cell immunity, as evidenced by eroding naive diversity and remodeled memory hierarchies. This generates an experienced yet constrained repertoire, with weakened protection against novel infections and malignancies and blunted vaccine responsiveness. However, the pace and extent of decline vary widely between individuals. Such heterogeneity signals a recalibration of immune priorities that favors persistence over plasticity of memory T cells. Here, we discuss how aging shapes...
The great education contradiction
Science, Volume 392, Issue 6793, April 2026.
Targeting modulated vascular smooth muscle cells in atherosclerosis via FAP-directed immunotherapy
Science, Volume 392, Issue 6793, April 2026.
A SWI/SNF-specific Ig-like domain, SWIFT, is a transcription factor binding platform
Science, Volume 392, Issue 6793, April 2026.
Blood-catalyzed n-doped polymers for reversible optical neural control
Science, Volume 392, Issue 6793, April 2026.
Harnessing viral strategies to reverse cognitive dysfunction through the integrated stress response
Science, Volume 392, Issue 6793, April 2026.
Protein and genomic language models uncover the unexplored diversity of bacterial immunity
Science, Volume 392, Issue 6793, April 2026.
Concurrent L1 retrotransposition events promote reciprocal translocations in human tumorigenesis
Science, Volume 392, Issue 6793, April 2026.
DefensePredictor: A machine learning model to discover prokaryotic immune systems
Science, Volume 392, Issue 6793, April 2026.
Mitochondrial metabolism and signaling direct dendritic cell function in antitumor immunity
Science, Volume 392, Issue 6793, April 2026.
Mix-and-match synthesis of 3D small molecules
China is planning to land people on the Moon — and might beat the United States to it
‘It’s a real shock’: quantum-computing breakthroughs pose imminent risks to cybersecurity
The Moon belongs to all of us — not just countries that can afford to reach it
How procrastination can rob you of career fulfilment in science
Regular physical activity in midlife cuts risk of early death
In Science Journals
Science, Volume 392, Issue 6793, Page 46-48, April 2026.