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Scientists at UCLA discovered a surprising reason aging muscles heal more slowly. In older muscle stem cells, a protein called NDRG1 builds up and acts like a brake, slowing the cells’ ability to jump into repair mode after injury. But there’s a twist: that same protein helps the cells survive the stresses of aging, allowing them to stick around longer.

Scientists have discovered that a common type of stroke may have a very different cause than doctors once thought. Instead of fatty plaque clogging arteries, the strongest link was found with enlarged and damaged blood vessels deep within the brain. The finding helps explain why standard treatments like aspirin are often less effective and is driving the search for new therapies that target the brain’s tiny blood vessels directly.

Bumble bees astonished researchers by inventing a new way to reach a hidden reward, despite never being taught the trick. The discovery adds to growing evidence that these tiny insects are far smarter and more adaptable than once believed.

A protein called “Mitch” may hold the key to a new generation of obesity treatments. Researchers found that disabling it in human cells boosts fat burning, increases energy use, and makes it harder for new fat cells to develop. The findings help explain why mice lacking Mitch were leaner, more athletic, and resistant to obesity.

A new spray-on powder developed by KAIST can stop life-threatening bleeding in about one second by instantly forming a strong gel over a wound. It works on deep and irregular injuries where conventional hemostatic products often struggle and remains effective even after years of storage in harsh conditions. Originally created for the battlefield, the technology could also transform emergency care in disasters, ambulances, and hospitals.

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Perturbations in lysosome integrity are tightly linked to neurological disorders and ageing, but the underlying pathogenic mechanisms are incompletely understood. Using an unbiased proteomic approach, we here identified the bridge-like lipid transport protein VPS13C/PARK23 as a key component of a global early response pathway to lysosome damage. VPS13C readily binds lysosomes under mechanical or osmotic tension in anticipation of membrane lesions. The latter trigger a conformational change in...

CONCLUSIONS AND IMPLICATIONS: Although HCBS availability varies across sites and regions, veterans' access also depends on VA staff time to conduct outreach, foster collaborations, and coordinate HCBS with internal and external partners. Understanding and disseminating effective strategies to strengthen veterans' HCBS access is vital as the need for HCBS continues to grow nationally.

CONCLUSIONS AND IMPLICATIONS: Clinical complexity, disability, and social vulnerabilities were associated with greater volumes of skilled home health provision from nurses and therapists from 2011 to 2015. Our results highlight care needs that may be underaddressed and inequities that may be exacerbated under current home health provisions.

CONCLUSIONS AND IMPLICATIONS: This study demonstrates that even a single fall can signal a significant shift in the health and functional trajectories of community-dwelling older people, reinforcing the need for proactive and coordinated prevention strategies.

There is great interest in characterizing the activities or lifestyle factors that are important for successful aging; nevertheless, rigorous investigations using multimodal neuroimaging measures in conjunction with validated measures of activities are underrepresented in the literature. To address this gap, we assessed whether engagement in complex mental activities across early, middle, and late life, is associated with metrics of brain health in a sample of cognitively unimpaired older adults...

Neural plasticity and memory mechanisms progressively change during pathological aging. This study aimed to identify patterns of structural covariance across Alzheimer's disease (AD) stages and their relationship with episodic memory performance. Fifty-nine AD patients, 59 patients with amnestic Mild Cognitive Impairment (a-MCI), 46 individuals with Subjective Cognitive Decline (SCD), and 49 Healthy Controls (HC) underwent neuropsychological assessment, including verbal episodic memory tests...

Hematopoietic stem cells integrate local and systemic cues to sustain blood homeostasis. In this issue of Cell Stem Cell, Tian et al.¹ uncover a stress-responsive brain-gut-bone marrow axis that drives aging-like dysfunction of hematopoietic stem cells.

Chronic stress influences hematopoietic stem cells (HSCs). However, how psychological stress regulates HSC function remains incompletely understood. Here, we show that psychological stress impairs HSC self-renewal and lymphoid differentiation, inducing aging-like phenotypes. Stress suppresses neuronal activity in the medial prefrontal cortex (mPFC) and periaqueductal gray (PAG), leading to HSC dysfunction, whereas chemogenetic activation of these regions restores HSC function. Psychological...

Atherosclerosis imposes a heavy burden on global healthcare systems and remains the leading cause of mortality worldwide, with macrophage dysfunction playing a critical role in its pathogenesis. This review examines the dual roles of macrophage senescence and programmed cell death (PCD) in the progression of atherosclerosis, highlighting their mechanisms, cross-talk and emerging therapeutic strategies. Macrophage senescence-characterized by irreversible cell cycle arrest, mitochondrial...

Oceanic trench bending over 1000 km occurs globally, with notable along-trench variations in mantle wedge thermochemistry. However, the mechanisms influencing both shallow trench geometry and deep mantle state remain unclear. Here we focus on the Mariana Trench as a representative case. Our 3D model successfully replicates its curved geometry. Modeling results further reveal that extensive intra-oceanic trench retreat and bending occur when the incoming plate features sharp density variations...

Perturbations in lysosome integrity are tightly linked to neurological disorders and ageing, but the underlying pathogenic mechanisms are incompletely understood. Using an unbiased proteomic approach, we here identified the bridge-like lipid transport protein VPS13C/PARK23 as a key component of a global early response pathway to lysosome damage. VPS13C readily binds lysosomes under mechanical or osmotic tension in anticipation of membrane lesions. The latter trigger a conformational change in...

Recent studies have highlighted the crucial role of mechanical properties in the ovarian microenvironment for ovarian function. However, the mechanisms that cause ovarian matrix stiffening during aging remain incompletely understood. Here we utilized atomic force microscopy (AFM) to demonstrate that human ovarian matrix stiffness increases with aging and in pathophysiological conditions, such as chemotherapy-induced premature ovarian insufficiency (POI), polycystic ovary syndrome (PCOS) and...

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