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A rare cancer-fighting plant compound has been decoded

4 hours 38 minutes ago
Scientists at UBC Okanagan have uncovered how plants produce mitraphylline, a rare natural compound with promising anti cancer potential. The team identified two enzymes that work together to build the molecule’s unusual twisted structure, solving a mystery that had puzzled researchers for years. Because mitraphylline appears only in tiny amounts in tropical plants like kratom and cat’s claw, the discovery could make it far easier to produce sustainably in the future.

Scientists discover a weak spot shared by polio and common cold viruses

4 hours 50 minutes ago
Scientists at the University of Maryland, Baltimore County, have uncovered a crucial trick used by enteroviruses—the group behind diseases like polio, myocarditis, encephalitis, and even the common cold—to reproduce inside human cells. The team captured, in unprecedented detail, how viral RNA recruits both viral and human proteins to assemble the machinery needed for replication, acting almost like a molecular “on-off switch” that controls whether the virus copies itself or makes proteins.

New drugs could wipe out the “zombie cells” linked to cancer and aging

5 hours 2 minutes ago
Researchers found a new way to kill harmful “zombie” cells that linger after chemotherapy and help cancers become more aggressive. These senescent cells survive by relying on a protective protein called GPX4, even while sitting on the edge of a deadly iron-triggered collapse. New drugs remove that protection, causing the cells to self-destruct. In mice, the approach reduced tumor size and boosted survival, hinting at a promising new cancer therapy.

Scientists reversed biological age in older adults with a 4-week diet change

17 hours 40 minutes ago
A four-week diet change was enough to make some older adults appear biologically younger in a new University of Sydney study. Participants who reduced fat intake or shifted toward more plant-based protein showed improvements in key health biomarkers tied to aging. The strongest results came from a lower-fat, higher-carb diet, while people eating closer to their usual diets saw almost no change.

Scientists discover hidden fat-burning switch that could strengthen bones

18 hours 26 minutes ago
Scientists at McGill University have uncovered a hidden molecular “switch” that turns on a powerful calorie-burning system in brown fat — the body’s heat-generating fat linked to metabolism and weight control. The breakthrough centers on glycerol, a molecule released when fat is broken down in the cold, which activates an enzyme called TNAP and triggers an alternative heat-producing pathway that scientists had struggled to explain for years.

Brain endothelial cell-derived extracellular vesicles (c-BEEVs) as a promising biomarker for brain vascular pathology and cognitive decline

20 hours 24 minutes ago
Accurate measurement of brain vascular pathology is essential for understanding its role in cognitive aging. Here we classified participants using the amyloid-tau-neurodegeneration framework in a multicenter cohort and identified cerebrospinal fluid brain endothelial-derived small extracellular vesicles (c-BEEVs) as a sensitive biomarker, which correlated with vascular risk factors and the severity of small-vessel disease. c-BEEVs showed high diagnostic performance for vascular cognitive...
Tongyao You

Temporal patterns of depressive symptoms and risk of osteoarthritis: A multi-cohort longitudinal analysis

20 hours 24 minutes ago
CONCLUSION: Adverse trajectories of depressive symptoms, particularly persistent and increasing patterns, are consistently associated with elevated osteoarthritis risk across diverse populations. These findings underscore the importance of longitudinal mental health monitoring and suggest that early intervention for depressive symptoms may represent a modifiable pathway for osteoarthritis prevention. The observed effect modification patterns highlight the need for population-specific and...
Haoran Zhu

Interpretable machine learning with SHAP analysis identifies redox-modulating dietary antioxidants for predicting accelerated biological aging

20 hours 24 minutes ago
CONCLUSION: The interpretable machine learning framework based on dietary antioxidant profiles can robustly predict accelerated biological aging. XGBoost demonstrated the best performance in predicting accelerated aging risk. Daidzein, apigenin, magnesium, zinc, and vitamin E are core dietary antioxidants closely associated with a reduced risk of accelerated biological aging. This study provides analytical reference at the large population level for the development of nutritional intervention...
Bei Zhang

The relationship between intrinsic capacity and functional ability - identifying key environmental features to support healthy ageing

20 hours 24 minutes ago
CONCLUSION: In addition to the vitality, cognition and psychology IC domains, environmental factors including sufficiency of care, housing prices and PM(10) showed important direct associations with FA. Interactions between IC and the environment primarily involved social environmental factors. Further longitudinal research is needed to clarify the mechanisms underlying these direct and interactive associations.
Jaro Govaerts

Association between adverse childhood experiences and intrinsic capacity impairment among middle-aged and older adults in China: A nationwide cross-sectional survey from CHARLS

20 hours 24 minutes ago
CONCLUSION: Greater degrees of ACEs exposure are associated with a heightened risk of IC impairment in middle-aged and older adults aged 45 and above in China. These findings highlight the importance of targeted screening and life-course trauma-informed care for individuals with high ACEs exposure in effectively identifying those at high risk of IC impairment and promoting healthy aging.
Xiaobing Xian

Immunotherapy for Senescent Cell Clearance: Hallmarks, Strategies and Translational Challenges

20 hours 24 minutes ago
Cellular senescence, a complex multifactorial process, is involved in the pathophysiology of various age-related diseases, such as cardiovascular disease and neurodegenerative disorders. Traditional interventions targeting single mechanisms yield limited efficacy. As a core hallmark and driver of aging, immunosenescence provides a critical target for precision interventions. This systematic review examines the hallmarks of aging, including cellular damage, epigenetic abnormalities, and...
Wenjie Zhang

Manganese (Hydr)oxides record the dynamic evolution of a million-year Hesperian Ocean in Utopia Planitia, Mars

20 hours 24 minutes ago
The duration and dynamic evolution of surface water on Mars are key to understanding its past habitability. Utopia Planitia, Mars' largest northern basin, preserves mineralogical signatures of ancient aqueous activity that remains chronologically unconstrained. Here, we present the quantitative reconstruction of the Hesperian Ocean's lifecycle using spectral analysis of manganese (Mn) (hydr)oxides as paleohydrological markers. Our innovative Spectral Contrastive-Aware Network, a deep learning...
Bingxu Hou

RNA imbalance as a hallmark of cellular ageing

20 hours 24 minutes ago
Major advances over the past few decades have highlighted the complex regulation of RNA from transcription to nuclear export and from translation to decay. Despite the emerging cellular landscape of malleable and multifunctional RNA molecules, the role of RNA dysregulation in ageing, one of the most fundamental processes of human biology, is underappreciated. Here we focus on ageing-linked dysregulation of the mRNA life cycle. We summarize how RNA metabolism steadily deviates throughout ageing...
Ping Sun

Optics-free spatial genomics for mapping mammalian brain aging by IRISeq

20 hours 24 minutes ago
Spatial transcriptomics has emerged as a transformative approach for in situ mapping of cellular heterogeneity and interactions, yet existing methods often compromise throughput, cost and tissue coverage. Here we introduce Imaging Reconstruction using Indexed Sequencing (IRISeq): an optics-free, cost-effective platform that leverages spatial interaction mapping by indexed sequencing to profile tissues at adjustable sizes and resolutions (5-50 µm). We applied IRISeq to map gene expression across...
Abdulraouf Abdulraouf