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Plasma Dilution After Myocardial Ischemia-Reperfusion Injury Promotes Cardiac Repair, Heart Performance, and Recovery of Motor Function and Endurance in Old Mice
Myocardial infarction (MI) is the leading cause of cardiovascular-related deaths worldwide, with risk increasing sharply with age. Fibrosis and inflammation occur soon after a pathological event and reflect perturbation of tissue repair that accompanies aging in general. Yet not old, but young animals are typically used for studying MI, emphasizing the unmet need for more relevant preclinical models. We previously determined that plasma dilution, also termed neutral blood exchange (NBE)...
Environmental Enrofloxacin Exposure as a Modifiable Driver of Mitochondria-Mediated Intestinal Aging and Barrier Dysfunction
Environmental antibiotic pollution is an underexplored contributor to gut aging and chronic intestinal diseases. We provide evidence that chronic exposure to enrofloxacin (ENR), a commonly detected veterinary antibiotic, accelerates gut aging and disease progression through a mitochondria-centered mechanism. In a population-based cross-sectional analysis, recent antibiotic use was associated with increased biological age and a higher risk of diarrhea in middle-aged and older adults, supporting a...
The environmental stress response regulates biophysics of the cytoplasm and survival in quiescence
All organisms employ strategies to cope with changing environmental conditions. In budding yeast, nutrient deprivation induces a reversible non-proliferative state known as quiescence, characterized by extensive remodeling of gene expression, metabolism, and cellular biophysical properties. Yeast cells survive prolonged periods of starvation-induced quiescence, provided they can respire in the early stages of glucose withdrawal, and blocking respiration causes premature aging and markedly...
Association between gut microbiota and sarcopenia in older adults: a cross-sectional analysis from the second wave of the Birjand Longitudinal Aging Study (BLAS)
CONCLUSION: This study demonstrates that specific gut microbial profiles are significantly associated with sarcopenia. Akkermansia and Lactobacillus were associated with sarcopenia, although greater Roseburia levels were beneficial. These microbial signatures are associated with sarcopenia and warrant further longitudinal investigation.
Seeking the right match: a hermeneutic phenomenological study of how older adults negotiate anthropomorphic perceptions, role identity and functional needs in elderly care robots
No abstract
Path analysis of subjective health status, healthy lifestyle habits, and successful aging in Korean older adults: path differences by age
No abstract
What matters most to the patient - a qualitative study of older patients in a geriatric ward
CONCLUSIONS: What mattered most to the patients was closely related to the World Health Organization's recommendations for ethical and good quality health care. Generally, the patients agreed on what mattered most. Further studies are needed to enrich the understanding of what is important to older patients.
Feeling Younger as an Indicator of Better Overall Intrinsic Capacities in the INSPIRE-T Cohort
CONCLUSIONS: This study demonstrates that feeling younger than one's age is associated with better overall intrinsic capacities at baseline and lesser decline over the monitoring period. Routine assessment of subjective age could help to identify individuals who may benefit from prevention strategies and could promote patient-centered care by providing deeper insights into individuals' perceptions of aging.
Measles explodes in Bangladesh after vaccination breakdown, killing hundreds of children
Changes to government’s vaccine purchase system after 2024 revolution led to nationwide shortages, gaps in immunity
To defeat gerrymandering, we must go back to the drawing board
Science, Volume 392, Issue 6797, April 2026.
Deeper detection limits in astronomical imaging using self-supervised spatiotemporal denoising
Science, Volume 392, Issue 6797, April 2026.
Bypassing the yellow phase for extremely stable formamidinium lead iodide perovskite solar cells
Science, Volume 392, Issue 6797, April 2026.
Toward life with a 19–amino acid alphabet through generative artificial intelligence design
Science, Volume 392, Issue 6797, April 2026.
Gene syntax defines supercoiling-mediated transcriptional feedback
Science, Volume 392, Issue 6797, April 2026.
Rumen ciliates modulate methane emissions in ruminants
Science, Volume 392, Issue 6797, April 2026.
Disordered protein LAT encodes relative levels of signaling pathways in T cell activation
Science, Volume 392, Issue 6797, April 2026.
Lymphoid tissue chemokines limit priming duration to preserve CD8+ T cell functionality
Science, Volume 392, Issue 6797, April 2026.