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Novel Therapeutic Insights Into Alzheimer's Disease: Glymphatic System and Meningeal Lymphatic Vessels

12 hours 36 minutes ago
With the acceleration of global aging, the relationship between Alzheimer's disease (AD) and the glymphatic system (GS) has become a research hotspot in the field of neuroscience in recent years. Traditionally, the central nervous system was thought to lack a lymphatic system; however, research over the past decade has overturned this view. Studies have revealed the existence of GS and meningeal lymphatic vessels (mLVs) in the brain, which clear metabolic waste (such as amyloid-β and tau...
Bingbing Song

Copper and iron engage distinct metabolic programs for cellular survival

12 hours 36 minutes ago
Copper and iron are redox-active micronutrients with tightly coupled homeostasis, yet how copper modulates iron-dependent stress responses remains unclear. Using Saccharomyces cerevisiae under nutrient-limited conditions, we uncoupled proliferative growth from long-term survival to dissect metal-dependent adaptation. Copper selectively preserved survival without affecting growth, whereas iron showed similar effects. Iron chelation impaired growth and suppressed electron transport chain gene...
Arshia Naaz

Lower bioelectrical phase angle is associated with audiometric hearing loss in middle-aged and older adults

12 hours 36 minutes ago
Bioelectrical phase angle is an integrated marker of cellular integrity, fluid distribution, nutritional status, and physiological reserve, but its relationship with objective sensory function in later life remains unclear. This population-based cross-sectional study analyzed adults aged 40 years or older from the 2022-2023 Korea National Health and Nutrition Examination Survey. Whole-body phase angle at 50 kHz was assessed using bioelectrical impedance analysis, and pure-tone audiometry was...
Ho Yun Lee

NAD(+) Metabolic Reprogramming Drives CD8(+) T Cells Senescence and Exacerbates Ulcerative Colitis

12 hours 36 minutes ago
While immunosenescence is increasingly implicated in chronic inflammatory disorders, its precise pathogenic contribution to ulcerative colitis (UC) remains elusive. Here, we identify senescent CD8^(+) T cells as a distinct pathogenic population that exacerbates colitis, demonstrating that systemic senolytic treatment significantly attenuates disease severity. Mechanistically, nicotinamide adenine dinucleotide (NAD^(+)) metabolic dysregulation triggers mitochondrial dysfunction and cytosolic...
Maolin Ye

Two serial MoCA assessments may support biomarker-sparing triage between Parkinson's disease/Lewy body dementia and frontotemporal dementia: a progressive inclusion analysis of 1,129 participants

12 hours 36 minutes ago
Reliable differentiation of Parkinson's disease/Lewy body dementia (PD/LBD) from frontotemporal dementia (FTD) affects treatment strategy and clinical trial eligibility, yet confirmatory biomarker testing remains costly and unevenly available. Whether routine cognitive trajectories can support testing prioritization has not been systematically quantified. We performed a progressive inclusion analysis of 1,129 National Alzheimer's Coordinating Center participants with PD/LBD (n = 385) or FTD (n =...
Wei Lin

Modulation of fronto-parietal and autonomic activity underpins preserved working memory in middle-aged adults

12 hours 36 minutes ago
CONCLUSION: Collectively, our data suggest that high WM performance in midlife depends on the flexible modulation of autonomic and cortical resources, potentially facilitating the attentional mobilization necessary for cognitive coping. These neurophysiological signatures allow clearer distinction between a chronological aging profile and a successful cognitive aging profile.
Myriam Cayre

Sustained Activation of CaMKII Promotes Skeletal Muscle Contractile Dysfunction in Aging

12 hours 36 minutes ago
Sarcopenia, the age-related loss of muscle strength and mass, contributes to adverse health outcomes in older adults. Exercise engages calcium (Ca^(2+))- and redox-dependent signaling pathways that enhance muscle performance and adaptation, whereas aging disrupts Ca^(2+) and redox homeostasis. CaMKII is a key transducer of both signals, raising the possibility that sustained CaMKII signaling becomes maladaptive with aging. Here, we show that CaMKII protein abundance is increased in aged mouse...
Michael R Bene

Novel Therapeutic Insights Into Alzheimer's Disease: Glymphatic System and Meningeal Lymphatic Vessels

12 hours 36 minutes ago
With the acceleration of global aging, the relationship between Alzheimer's disease (AD) and the glymphatic system (GS) has become a research hotspot in the field of neuroscience in recent years. Traditionally, the central nervous system was thought to lack a lymphatic system; however, research over the past decade has overturned this view. Studies have revealed the existence of GS and meningeal lymphatic vessels (mLVs) in the brain, which clear metabolic waste (such as amyloid-β and tau...
Bingbing Song

Mitochondrial homeodynamics in ageing: mechanisms, resilience, and interventions

12 hours 36 minutes ago
Mitochondria integrate bioenergetics, redox signalling, calcium handling, biosynthesis, apoptosis, and stress responses. Their contribution to ageing depends less on any single pathway than on the ability to sustain these functions through continuous maintenance, remodelling, and inter-organelle communication. This review proposes mitochondrial homeodynamics as a systems-level framework for that ability, which rests not on static preservation but on three linked capacities. Maintenance...
Piotr Paweł Chmielewski

Apolipoprotein(a)-rich electronegative HDL accelerates vascular aging and atherosclerosis by inducing endothelial senescence

12 hours 36 minutes ago
The limited benefits of high-density lipoprotein (HDL)-targeted therapies have shifted the research focus to HDL quality; some HDL subtypes may be pro-atherogenic and may counteract the potential benefits of HDL therapies. This study investigated the pathological mechanism of H5, a highly electronegative and compositionally abnormal HDL subfraction characterized by impaired cholesterol efflux. We used anion-exchange chromatography to separate HDL into five subfractions (H1-H5) from blood from...
Wen-Li Hsu

Reduced sensorimotor lactate concentration and improved sleep efficiency following resistance training in older adults

12 hours 36 minutes ago
As populations age worldwide, pathological neurodegeneration with subsequent cognitive decline has emerged as a pressing public health challenge. As effective treatments remain limited once neurodegeneration has occurred, prevention and delay of decline onset are crucial. While physical exercise is associated with improved cognition, exercise-specific mechanisms remain unclear. We therefore examined the effects of 12 weeks explosive lower-body resistance training (RT) in community-dwelling older...
Selin Scherrer

Association between vascular risk factors and white matter integrity among diverse predominantly older Hispanic/Latino adults from the SOL-INCA MRI study

12 hours 36 minutes ago
Cerebral small vessel disease is a major contributor to stroke and cognitive decline and is characterized by white matter hyperintensities (WMH) and microstructural alterations detectable via diffusion-weighted imaging parameters, including free water (FW) and fractional anisotropy (FA). Hispanic/Latino populations experience a high burden of vascular risk factors. However, the impact of these factors on white matter integrity across diverse heritage groups remains underexplored in this...
Elmira Agah

Glycan recognition by a plant damage-sensing immune receptor

16 hours 35 minutes ago
Science, Ahead of Print.
Pedro Jiménez-Sandoval, Owen Kentish, Caroline Broyart, Hyun Kyung Lee, Klara Culjak, Uwe Osswald, Meriem Aitouguinane, Emanuele Tettamanti, Manon Schmidli, Lu Zhang, Louis-Philippe Maier, Charles Roussin-Léveillée, Diego José Berlanga, Marina Martin…