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The coordination of proteostasis between the brain and peripheral tissues is essential for the health and survival of all animals. In C. elegans, glia coordinate organismal proteostasis and longevity via the unfolded protein response of the endoplasmic reticulum (UPR^(ER)). However, the signaling molecules required remain unknown. Here, we show that glial UPR^(ER) activation increases levels of specific neuropeptides. We identify a single neuropeptide, FLP-17, that is sufficient but not...

Mammals are constantly exposed to various stressors of internal and external origin. Though hair follicles (HFs) are exquisitely sensitive to stress, it remains largely unknown how stress-induced responses are linked with the intrinsic regulators of HF growth, cycling, and regeneration. Here, we characterize the long-range enhancer of Sonic hedgehog (Shh) gene which encodes a crucial mitogen in the HF, and identify a hair stress-responsive enhancer (HSRE) as a unified target on which various...

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In our society, the aging of the population is a major public health concern. Recently we have identified a new snoRNA (jouvence) in Drosophila, and showed that its deletion (F4) reduces lifespan, while its overexpression increases it. F4 deleted flies also present neurodegenerative lesions and a deregulation of metabolic parameters such as triglycerides and sterols. However, a deeper characterization of this genomic locus has revealed the presence of two additional snoRNAs. Here, we have...

The Department of State hasn’t given the Centers for Disease Control and Prevention all the money it needs to keep vital AIDS relief programs operating