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The Immune Cell Atlas of "Longevity Molecular Tag": Identification of Principal Immune Cell Subsets and Their Underlying Molecular Regulatory Mechanisms

22 hours 53 minutes ago
Immunosenescence represents a critical aspect of the aging process. Centenarians, serving as a nature model of "healthy aging," demonstrate a distinctive immune "compensatory adaptation" mechanism that contributes to the maintenance of immune homeostasis. However, the specific immune cell subsets involved and the molecular mechanisms underlying these phenotypic traits remain incompletely understood. In this study, we integrated single-cell RNA sequencing data spanning the entire lifespan of East...
Zhiling Zhang

Nucleosome spacing across cell types, diseases, and ages

22 hours 53 minutes ago
Nucleosome spacing patterns in the genome form a unique signature of a given cell, reflecting its chromatin organization and gene expression. Recently, studies of nucleosome spacing have expanded substantially due to the development of novel experimental tools and increased analysis of human samples. This has yielded thousands of high-resolution nucleosome maps across many species and cell types, as well as multiple human datasets that span across different ages and health conditions. With the...
Milena Bikova