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Targeting RANKL Prevents Bone Loss, Improves Muscle Function and Extends Lifespan in Progeroid Mice
Hutchinson-Gilford progeria syndrome (HGPS) is a rare genetic disorder characterized by the early development of pathological features associated with aging, ultimately leading to premature death. HGPS primarily affects tissues of mesenchymal origin, as evidenced by the clinical manifestations characteristic of this premature aging disorder, including, but not limited to, osteoporosis, muscle wasting, lipodystrophy, and cardiovascular disease. In this study, we used preclinical mouse models and...
Despite global turmoil, Gen Z researchers are not giving up
This AI tool claims to pick the top 1% of preprints. Should researchers trust it?
Why environmental treaties must also address mental health
What to do when you have too many PhD projects on the go
I caught my students using AI to cheat in an exam — here’s what universities must do to stamp this out
Author Correction: Nucleolar URB1 ensures 3′ ETS rRNA removal to prevent exosome surveillance
Author Correction: Cooperation conflicts with equality when allocating public goods
Author Correction: Durable all-inorganic perovskite tandem photovoltaics
Frequent cannabis users wake up with their “stress hormone” already elevated
Frequent cannabis users may wake up with unusually high levels of the stress hormone cortisol, suggesting their daily stress rhythms could be disrupted. Researchers say the finding raises questions about whether using cannabis for stress relief might, over time, interfere with the very system that helps the body handle stress.
For decades, we were told to choose low-fat dairy. New research says otherwise
Full-fat dairy may be healthier than conventional advice has suggested. In a 12-week study, adults who ate three servings a day showed no meaningful increases in weight, body fat, cholesterol, or insulin resistance. They also experienced improved blood pressure and consumed more calcium, protein, and vitamin D. The findings suggest dairy’s complex structure may matter more than its saturated fat content alone.
Mitochondria Dictate Progressive Versus Bimodal Aging of the Mammary Gland
The incidence of breast cancer shows its largest peak around the age of 65 but also a peak around 45 indicating a bimodal distribution. While some potential explanations, such as age-related enrichment in specific breast cancer sub-types and BRCA1/2 mutations were proposed, they do not explain why the peaks are at 45 and 65, raising the possibility that the way the breast ages may play a role. Here using two mouse models, we show two distinct aging patterns of the mammary gland; one being...
Wine, beer, or spirits? Massive study finds a surprising health divide
A study tracking more than 340,000 adults for over a decade found that heavy drinking increased the risk of death regardless of beverage type. At lower levels, however, the picture became more surprising: beer, cider, and spirits were linked to higher mortality, while wine was associated with lower risk. Moderate wine drinkers had a 21% lower risk of cardiovascular death compared with people who rarely or never drank.
Scientists say just 7 days of meditation can rewire your brain
An intensive seven-day meditation retreat triggered striking changes across the brain and body, including shifts tied to neuroplasticity, immunity, metabolism, and natural pain relief. Participants also showed brain connectivity patterns resembling those associated with psychedelic experiences, suggesting that powerful altered states may be achievable without drugs.
Stress can scramble your brain’s internal GPS, MRI study finds
Stress may literally scramble the brain’s internal GPS. Researchers found that cortisol, a hormone released during stress, made people significantly worse at navigating a virtual environment and disrupted the precise activity of grid cells, specialized brain cells that help us understand where we are in space. When landmarks were missing, this navigation system nearly stopped functioning, while another brain region appeared to step in and compensate.
Scientists reveal how much exercise you really need to protect your heart
Getting the recommended 150 minutes of moderate-to-vigorous exercise each week may offer only modest protection against heart attacks and strokes. A large study suggests that substantially greater benefits may require roughly 560 to 610 minutes a week—nearly 9 to 10 hours of brisk walking, running, cycling, or similar activity.
A protein older than blood circulation could transform cancer immunotherapy
A protein that evolved long before the human circulatory system may help unlock stronger cancer treatments. When C3 is produced inside tumors, it blocks immune-suppressing cells and gives immunotherapy a better chance to work. Researchers were even able to recreate this effect in resistant tumors, significantly improving survival in mice.
Cutting sweet foods doesn’t curb cravings or improve health
Changing how much sweet-tasting food people eat may not change how much they crave or enjoy sweetness after all. In a six-month trial, researchers found that people assigned to high-, low-, or average-sweetness diets showed no meaningful differences in their preference for sweet foods, body weight, or markers linked to diabetes and heart disease. Many participants also drifted back toward their previous eating habits once the trial ended.
Senate votes to block rule giving White House more control over research
Language is part of bill to fund government until mid-December
APOE3 and APOE4 human astrocytes differentially modulate Alzheimer's disease pathology and microglial responses in chimeric mice
Astrocytes and APOE are strongly implicated in Alzheimer's disease (AD), yet the impact of astrocytes carrying different APOE variants on AD hallmarks remains incompletely understood. Here, we generate a chimeric model of AD by transplanting isogenic APOE3 or APOE4 human induced pluripotent stem cell-derived astrocyte progenitors into neonatal AD mice. Donor cells differentiate into human astrocytes that integrate into the cortex and display morphologies consistent with interlaminar-like...