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A new study reveals that viral infections may leave behind hidden damage to the immune system long after symptoms disappear. Researchers found that mice recovering from an acute infection experienced lasting changes to their spleens and weakened immune responses, potentially leaving them more vulnerable to future threats. Surprisingly, prior vaccination completely prevented these harmful changes in the mouse model.

A study of more than 750,000 pregnancies found that early exposure to Ozempic, Wegovy, and similar drugs was not linked to increased pregnancy complications when used for weight loss, but was associated with a higher risk of premature birth when prescribed for diabetes. The surprising difference suggests that diabetes itself may be driving the risk, although researchers caution that the drugs' safety during pregnancy remains uncertain.

A major study of nearly 1,900 older adults suggests that stopping statins after age 70 may be relatively safe in the short term for people who have never experienced a heart attack or stroke. However, a higher rate of serious cardiovascular events or death during longer follow-up raises questions about the risks of discontinuing these widely prescribed medications.

Mild disruptions to mitochondrial function can lead to the activation of an adaptive program that extends animal lifespan. The mitochondrial unfolded protein response (UPRmt) is associated with such conditions that prolong lifespan. We previously discovered that methionine restriction, resulting from the genetic loss of methionine synthase in C. elegans, activated the UPRmt and extended lifespan. Here, we demonstrate that methionine restriction activates the UPRmt and delays aging within the...

Researchers have uncovered a surprising hidden function of a protein that may hold the key to repairing damaged muscles and treating muscular dystrophy. Known for protecting chromosomes, TRF2 also helps muscle stem cells maintain their identity and regenerate injured tissue. When scientists removed the protein in mice, muscles struggled to repair themselves, and muscular dystrophy progressed dramatically faster.

A surprising new study suggests that where men get their protein may be linked to their testosterone levels. Researchers studying more than 2,500 men found that higher animal protein intake, particularly from dairy, was associated with lower testosterone, while plant protein was linked to higher levels. The findings raise intriguing questions about how everyday food choices might relate to male hormone levels.

Stanford researchers have discovered that children who struggle persistently with math may have underlying differences in how their brains manage problem-solving strategies. Children with developmental dyscalculia were slower to switch strategies, less responsive to changes in difficulty, and less able to improve their approach over time. Distinct patterns of brain activity were linked to these difficulties and could even predict certain math-related abilities.

Crows may be even smarter than we thought, and their brains are astonishingly fast. Researchers at the University of Tübingen discovered that crows can make visual decisions twice as quickly as humans and monkeys, taking just 235 milliseconds on average to identify the direction of moving dots while maintaining remarkable accuracy.

Colorectal cancer is making an alarming comeback in the United States after more than 20 years of declining rates, and the increase is no longer limited to younger adults. A major new study found rising rates across nearly every age group under 70, including older Americans who have historically benefited most from cancer screening.

Scientists have developed an AI-powered approach that makes experimental bionic vision technology more precise, helping predict the flashes and shapes of light perceived by a blind man with a brain implant. By learning how an individual's brain responds to electrical stimulation, the technology could bring researchers closer to restoring some degree of sight to people with blindness.

Healthy aging is shaped by the exposome-the accumulation of exposures experienced across the life course arising from intersections of the natural, physical, social, community and policy environments in which people age. This Consensus Statement reports recommendations from the Gateway Exposome Coordinating Center to accelerate life-course research on the exposome's impacts on healthy aging, including Alzheimer's disease and related dementias. Recommendations centered on five themes are...

Aging is a complex biological process often characterized by increased vulnerability to disease, infection, and death. This increased vulnerability is mechanistically linked to a progressive and functional decline of the immune system. In humans, aged T cells lose their ability to effectively surveil complex microenvironments, thereby decreasing their capacity to clear infections, eradicate diseases, and maintain physiological homeostasis. However, specific mechanisms by which aged T cells lose...

Circulating non-cellular factors, such as plasma proteins, contribute to various features of aging. To determine the impacts of endogenous circulating factors on human age-related bioenergetic decline, we treated primary human fibroblasts with serum samples representing the adult life-course. Our results demonstrate that the maximal mitochondrial bioenergetic capacity of fibroblasts treated with serum is negatively correlated with the chronological and epigenetic age of the serum donor. Using...

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Social and economic conditions shape healthy aging, but it remains unclear whether policies that modify these conditions change aging-related biomarkers or later-life functional trajectories. The growing availability of biomarker data in longitudinal cohorts, together with the wider use of experimental and quasi-experimental designs in social policy research, creates new opportunities to evaluate how social conditions become biologically embedded. We argue that policy experiments can strengthen...

Social gradients in health and aging are well documented in human societies: individuals who experience low social status, loneliness or early-life adversities show accelerated biological aging, an increased burden of chronic diseases and a lower survival rate. However, how these exposures become biologically embedded remains incompletely understood, and causal inference remains limited. Here, we discuss emerging natural and experimental animal models of the social determinants of aging, which...

Social determinants of health, the conditions in which people are born, grow, live, work and age, shape brain aging and dementia. Yet evidence is dominated by Global North populations and often relies on single indicators (for example, education or income), limiting risk characterization and generalizability across settings. This Perspective provides a global, integrative overview of multidimensional, multilevel and life-course approaches to social determinants of health and exposome research in...