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A major analysis suggests Phelan-McDermid syndrome, a genetic disorder closely linked to autism, may affect about 1 in 7,300 people and more than 45,000 Americans. Researchers warn that thousands of cases may remain hidden because genetic testing is often not performed, even as targeted treatments move into clinical trials.

Researchers used CRISPR to remove CD33 from donor stem cells, potentially giving doctors a way to attack aggressive blood cancers without destroying the healthy cells patients need after a transplant. In a 30-patient trial, the edited cells successfully took hold and appeared to shield blood cells from a CD33-targeted cancer treatment.

Imminent change in legal status raises concerns that national academy will serve political interests

First clean pictures from a muon beam point to a new way to peer inside suspicious packages and ancient structures

Navigation in the real world may rely on a multitude of strategies with distinct advantages and disadvantages; however, the characterization of spontaneous strategy use is scarce. We explore data across three groups engaged in virtual navigation: patients with epilepsy undergoing invasive electrophysiological recordings, two groups undergoing fMRI scanning: young adults at genetic risk for Alzheimer's disease (APOE-ε4 carriers), and healthy controls. We establish metrics to quantitatively...

Amyloid aggregates of α-Synuclein are hallmarks of Parkinson's disease (PD) and related neurodegenerative disorders. Literature suggests that mRNA G-quadruplexes (rG4s) bind to α-Synuclein, facilitating its amyloidogenesis. In parallel, α-Synuclein interacts with RNA-binding proteins (RBPs) within cytosolic RNA-protein granules to modulate mRNA stability. However, mechanisms by which α-Synuclein-interacting RBPs regulate its amyloidogenesis remain unexplored. Here, we report that rG4-dependent...

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Aging is a progressive decline in physiological functions and the capacity to maintain homeostasis, representing a major risk factor for numerous chronic diseases. Geroprotectors, defined as natural or synthetic compounds capable of improving healthspan and delaying age-associated functional decline, have attracted increasing attention in aging research. However, clinically validated interventions for promoting healthy aging remain unavailable. Plant-derived polysaccharides, owing to their...

Erigeron breviscapus Hand-Mazz. (EBHM) is a well-documented herbal medicine with recognized antioxidant, anti-apoptotic, and anti-inflammatory bioactivities. However, its anti-senescence effects and the underlying mechanisms remain poorly understood. Here, we investigated the anti-senescence potential of EBHM employing Caenorhabditis elegans and SAMP8 mice. In C. elegans, EBHM treatment prolonged the average lifespan of C. elegans to a maximum of 18.68%, while also significantly enhancing stress...

CONCLUSION: Gait mat and stopwatch measurements showed acceptable agreement, supporting clinical use. However, greater disagreement at faster speeds suggests gait mats may be more appropriate for faster walking speeds. These findings support future investigations of ST and DT gait performance within ARIC and other aging cohorts, including relationships with cognitive decline, mobility limitations, and adverse health outcomes.

INTRODUCTION: Since many hospitalized older adults have delirium, assessment of baseline cognitive function often requires proxy-based measures. While the 16-item Informant Questionnaire on Cognitive Decline in Elderly (IQCODE) specifies cutoff scores for mild cognitive impairment (MCI) and dementia, the 8-item Informant Interview to Differentiate Aging and Dementia (AD8) provides only a single cutoff for "cognitive impairment," limiting its usefulness and precision. Our aim was to develop a...

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