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Homebound status and glycemic control among older adults: results from a national survey
Despite well-documented poor health outcomes among homebound older adults with diabetes, little is known about how homebound status affects glycemic outcomes. This study examined the association between homebound status and glycemic control among community-dwelling older adults with diabetes and identified key factors associated with glycemic outcomes. We conducted a cross-sectional analysis using data from the 2017 National Health and Aging Trends Survey (NHATS). Participants included...
MSC-derived extracellular vesicles accelerate wound healing in senescent fibroblast cultures
Wound healing (WH) is a multi-component and highly orchestrated process, in which fibroblasts play a pivotal role. Wound healing is commonly attenuated during aging and the course of cellular senescence (CS). A growing body of evidence demonstrates that mesenchymal stem cell (MSC)-derived extracellular vesicles (EVs) can mitigate the aging and CS phenotype. In this study, we evaluated the effects of EVs derived from naïve MSCs (nMSCs) or anti-inflammatory polarized MSCs (pMSCs) on the rate of in...
Long-term outcomes of evolving treatment regimens in Ewing sarcoma survivors diagnosed 1970-1999: A report from the Childhood Cancer Survivor Study
CONCLUSIONS: No differences in late mortality, SMNs, and most CHCs were observed between patients who received VDC versus VDC/IE. Aging EWS survivors' elevated risk of morbidity and mortality underscores the need for lifelong survivorship care and therapies that reduce the risk for late effects.
Determinants of spiritual well-being in older adults: the role of geriatric assessment domains and religious coping
CONCLUSIONS: Depressive symptoms appear to be the dominant negative correlate of spiritual well-being in geriatric outpatients, while religious coping shows an independent positive link. The attenuation of functional measures after accounting for depressive symptoms may align with gerotranscendence theory or simply reflect ceiling effects in this functionally well-preserved outpatient sample. Either way, these data underscore the relevance of addressing depressive symptoms and acknowledging...
Social participation and subjective well-being among older adults: item-level evidence and screening potential in an East Asian aging society
CONCLUSION: Higher social participation is strongly associated with better subjective well-being in older adults, particularly through relational and health-oriented activities. Social participation scores may serve as a useful community-based indicator for detecting low well-being. Culturally sensitive interventions that promote meaningful, voluntary, and inclusive participation-alongside structural supports such as transportation and social prescribing-may help enhance psychological well-being...
Patient-reported measures of physical activity level for older adults in the home care setting: a systematic review and assessment of psychometric properties
CONCLUSIONS: CHAMPS, PASE, and LAPAQ showed the most acceptable psychometric properties. Most PROMs had limited responsiveness and inconsistencies. Implementation should focus on robust PROMs, while research should enhance measurement quality, validate tools in home care settings, and standardize measurement methods.
Determinants of medical students' perceptions of older people: a cross-sectional study
CONCLUSIONS: Medical students mostly demonstrated positive attitudes towards older people, particularly in terms of respect and willingness to provide support. Regular contact with older people and appropriately designed gerontological education may contribute to more positive attitudes towards older adults and help counteract ageism among future healthcare professionals.
Age-Associated Senescence of Decidual Macrophages: A Key Mediator of Adverse Pregnancy Outcomes in Advanced Maternal Age
Senescence of immune cells can drive senescence of solid organs, and reversing immune cell senescence ameliorates organismal senescence phenotypes. As the second largest subset of decidual immune cells, macrophages play a critical role in pregnancy. However, whether decidual macrophages (DM) exhibit senescence in advanced maternal age (AMA) pregnancies (≥ 35 years old) and their involvement in AMA-related adverse outcomes remain undefined. This study elucidates the phenotypic and functional...
Modulating IL-11-dependent matrix stiffness to delay ovarian aging
Mapping the network architecture of aging to identify repurposable drug candidates for longevity
Targeting interleukin-11 to slow ovarian aging
Author Correction: Synthesis of enantioenriched atropisomers by biocatalytic deracemization
Electrodeposited self-assembled molecules for perovskite photovoltaics
Incoming US science academy chief vows to ‘double down’ on research
Can you actually do a nine-to-five PhD? <i>Nature</i> readers weigh in
A CDK1 phospho-switch reprograms TRAIP to unload replisomes in mitosis
Science, Ahead of Print.
TTF2 processes sites of incomplete DNA replication during mitosis via sister-chromatid exchanges
Science, Ahead of Print.
Manipulation of protein translation and stem cell self-renewal by CRISPR activation of rRNA transcription
Science, Ahead of Print.
Hierarchical sensory processing in zebrafish thalamocortical-like circuits
Science, Ahead of Print.
How an ancient continental breakup helped spawn the Antarctic Ice Sheet
Mantle waves and tectonic stretching lofted polar mountains into a deep freeze