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Associations of psychosocial factors with cardiovascular health in aging: insights from the Inlife-Aging Project

1 day 6 hours ago
Life's Essential 8 (LE8) provides a multidimensional framework to assess cardiovascular health (CVH) in aging populations. The objective of this study was to describe LE8 component scores and their variation by age, sex, and psychosocial factors in middle-aged and older adults from Cádiz, Spain. Cross-sectional data were analyzed from 495 adults aged 50-79 years (59.4% women; 34.7% ≥ 65 years). LE8 scores were calculated following American Heart Association guidelines. Group comparisons used...
Iván H Martín-Costa

Metformin attenuates lens epithelial cell senescence by suppressing cGAS-STING via SIRT1-PGC-1alpha-mediated mitochondrial fission

1 day 6 hours ago
UVB-induced lens epithelial cell (LEC) senescence is among the important factors involved in the pathogenesis of age-related cataract (ARC). This study aimed to investigate the anti-aging effect of metformin (Met) and to elucidate the molecular mechanisms underlying this effect. RNA sequencing, nontargeted metabolomics analysis and network pharmacology were conducted. The expression of senescence indicators (P53 and P21^(Cip1)) and senescence-associated β-galactosidase (SA-β-gal) activity were...
Jialin Luo

Prevalence and associated factors of geriatric syndromes using an online self-administered screening tool based on the ICOPE framework in primary care

1 day 6 hours ago
CONCLUSIONS: A self-administered online geriatric screening tool adapted from the ICOPE framework is feasible, acceptable, and effective in detecting GSs in primary care. The high prevalence of GSs highlights the urgent need for scalable digital solutions. Integrating online screening into primary care workflows could facilitate early identification, optimize resource use, and promote healthy aging in resource-constrained settings.
Patsri Srisuwan

Cancer cachexia induces senescent reprogramming of brown adipose tissue and pro-cachectic S100A9 secretion by adipocytes

1 day 6 hours ago
Cancer-associated cachexia (CAC) is a multifactorial wasting syndrome characterized by progressive loss of fat and lean mass, systemic inflammation, and poor therapeutic responsiveness. While brown adipose tissue (BAT) is traditionally considered a protective, energy-dissipating organ, its qualitative remodeling in CAC remains poorly characterized.Here, we demonstrate that CAC induces a senescent conversion of BAT, marked by thermogenic failure, fibrosis, inflammation, and acquisition of a...
Claudia Di Biagio

Effects of a brief aging simulation suit intervention on clinical empathy in healthcare professionals working in long-term care: a randomized controlled trial

1 day 6 hours ago
CONCLUSIONS: The use of an aging simulation suit was associated with improvements in specific dimensions of clinical empathy among healthcare professionals working in long-term care. This educational tool offers a valuable experiential approach that enhances understanding and compassion toward older adults. However, these findings are limited to short-term, self-reported measures, and no behavioral or patient outcome data were collected. Further longitudinal studies are needed to determine the...
Sergio Serrada-Tejeda

Escherichia coli Nissle 1917 alleviates Alzheimer's disease in mice through OmpA-containing outer membrane vesicles

2 days 6 hours ago
Gut microbiota dysbiosis is a driving factor in Alzheimer's disease (AD), yet the mechanisms behind remain elusive. Emerging evidence highlights that outer membrane vesicles (OMVs) are critical mediators of microbiota-host communication. Here, we observed a reduction in a gut probiotic Escherichia coli Nissle 1917 (EcN)-like strain in AD patients, and its levels are positively associated with cognitive ability. The EcN OMVs containing outer membrane protein A (OmpA) translocate to the brain,...
Junhua Xie

From stability to pathology: protein degradation pathways underlying synaptic proteins in neurological diseases

2 days 6 hours ago
Synaptic function and plasticity depend on the precise control of protein abundance and turnover, governed by the balance of synthesis and degradation. This review examines the regulatory mechanisms that maintain synaptic protein stability, focusing on the Ubiquitin-Proteasome System (UPS), autophagy-lysosomal pathways, and related proteolytic systems. We detail how key enzymes, including E3 ligases such as Nedd4-1, Mdm2, and Parkin, and deubiquitinating enzymes like USP46 and USP8, dynamically...
Yuanyuan Li

Building an ontology of resilience: Insights from the physical resilience literature

2 days 6 hours ago
Physical resilience is a term used to describe an individual's response to physical and physiological stressors across the fields of gerontology and rehabilitation sciences. However, the term has not yet undergone a rigorous examination of its underlying assumptions, which has hindered its theoretical development and empirical measurement. This paper reviews the existing definitions of physical resilience in the context of human physical and psychological systems to examine its underlying,...
John Manning

Regulatory Mechanisms of Age-related Degenerative Diseases: Insights from the Gut Microbiota-Cellular Senescence Interaction Network

2 days 6 hours ago
Global population aging has sharply increased the prevalence of age-related degenerative diseases, posing severe challenges to global public health and socioeconomic stability. Growing evidence links these disorders to the bidirectional crosstalk between gut microbiota and cellular senescence, yet the integrated interaction network governing multi-organ degeneration remains poorly defined. Age-related gut microbial remodeling reshapes metabolite profiles: beneficial metabolites mitigate cellular...
Peng Sun

Advancing healthy ageing in Greece: the WHO ICOPE protocol within the JA PreventNCD framework

2 days 6 hours ago
CONCLUSION: This protocol represents the first structured effort to embed the WHO ICOPE model within the Greek healthcare system. By integrating professional training, community-based assessment, and digital documentation, the initiative aims to strengthen person-centred care, prevent dependency, and align national ageing policies with international standards.
Theodoula Adamakidou

The glymphatic system and meningeal lymphatic vessels: from physiology to pathophysiology, with insights into visualization

2 days 6 hours ago
The lymphatic system plays critical roles in immune defense, fluid homeostasis, substance metabolism, and cellular communication. Traditionally, it was believed that the vertebrate brain lacked a classical lymphatic system. Studies have revealed the presence of the glymphatic system (GS) and meningeal lymphatic vessels (MLVs), which are thought to play important roles in regulating material transport and immune processes within the central nervous system (CNS), in ways that resemble aspects of...
Zhixuan Li

Activating p53<sup>Y220C</sup> with a mutant-specific small molecule

2 days 6 hours ago
TP53 is the most commonly mutated gene in cancer, but it remains recalcitrant to clinically meaningful therapeutic reactivation. We present here the discovery and characterization of a small molecule chemical inducer of proximity that activates mutant p53. We named this compound TRanscriptional Activator of p53 (TRAP-1) due to its ability to engage p53^(Y220C) and BRD4 in a ternary complex, which potently activates mutant p53 and triggers robust p53 target gene transcription. Treatment of...
Xijun Zhu

Distribution of dementia severity and its functional correlates in community-dwelling older adults in Vietnam

2 days 6 hours ago
CONCLUSION: This study provides community-based evidence on dementia severity among older adults in two districts of Hai Duong province, Vietnam, showing that more than half of participants had moderate-to-severe dementia. Functional independence and quality of life were associated with dementia severity and may represent important considerations when designing community-based dementia care strategies.
Huong Thu Vu

SIRT1 Downregulation by Advanced Glycation End Products Activates RANKL-Dependent Osteoclast Signaling and Drives Chondrocyte Senescence During Osteoarthritis Development

2 days 6 hours ago
Advanced glycation end products (AGEs) accumulate with aging and metabolic stress and are increasingly implicated in osteoarthritis (OA) pathology. However, how AGEs regulate osteoclast-chondrocyte signaling remains poorly defined. Here, we integrated proteomic and transcriptomic analyses with machine learning to identify molecular networks altered by AGEs in osteoclasts. SIRT1 emerged as a central regulator suppressed following AGE exposure. Loss of SIRT1 deacetylase activity activated the...
Yizhou Li

Piezoelectric neuromodulation of the subthalamic nucleus ameliorates motor and nonmotor symptoms of Parkinson's disease

2 days 6 hours ago
Traditional deep-brain stimulation via implanted electrodes can effectively treat neurological disorders, but surgical injury limits its clinical application. Here, we developed ultrasound-responsive piezoelectric nanoparticles for minimal-invasive and wireless neuromodulation. In the 6-OHDA-induced Parkinson's disease (PD) mouse model, these nanoparticles are injected into the subthalamic nucleus (STN) of the mouse brain. After ultrasound stimulation for several days, the motor behavior,...
Di Zhao

Stress-induced CXCL13 regulates pancreatic exocrine homeostasis, age-related chronic inflammation, and cancer progression

2 days 6 hours ago
Pancreatic cancers, whose incidence increases with age, are often refractory to treatment. Here, we identified a core mechanism shared by physiological homeostasis, senescent cell accumulation during aging, and pancreatic cancers. Pancreatic acinar cells, when stressed, secrete CXCL13, which protects stressed cells while transiently activating paracrine Hippo/YAP signaling to induce proliferation and PD-L1-mediated immune protection to maintain organ homeostasis. In the aged pancreas,...
Masahiro Yoshida