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Comparison of hip abduction range of motion and strength and ankle dorsiflexion in older adults with and without a history of falls
CONCLUSION: Concurrent weakness in the hip abductors and ankle dorsiflexors may be associated with an increased risk of falls in older adults. Combined assessment of muscle strength and range of motion in these regions may assist in identifying older adults with characteristics associated with fall history.
British ‘First Fleet’ brought smallpox to Australia—and may have killed millions
Two papers pin the deadly disease’s introduction on British colonists and suggest the continent held far more people than previously believed
How to avoid dementia — what the science really says
Keep the Hubble and James Webb Space Telescopes alive — the science is worth the price tag
Save Hubble: the race to preserve the space telescope kicks off
How to widen access to the critical minerals that the world needs
How long can humans live? All evidence points to a maximum of 125 years
AI can cause harm: safeguards must catch up
Listen to Gen Z when it comes to AI in education
Publisher Correction: A 98-qubit trapped-ion quantum computer with all-to-all connectivity
Scientists discover why exercise reverses muscle aging
Researchers have uncovered a molecular “switch” that helps explain why exercise keeps ageing muscles healthy. By reducing levels of a gene called DEAF1, physical activity allows older muscles to clear out damage, repair themselves, and maintain strength.
Scientists solve a 30-year rye pollen mystery that could transform cancer research
Scientists have finally solved a nearly 30-year-old mystery surrounding two unusual molecules found in rye pollen that once showed an intriguing ability to help animals fight tumors. By determining their exact 3D structures, researchers have unlocked the blueprint needed to investigate how these natural compounds interact with the immune system and which parts may be responsible for their cancer-fighting effects.
Scientists want to quarantine alien life on the Moon before it reaches Earth
Scientists are calling for a lunar quarantine facility where samples from Mars, the Moon, and beyond would be examined before being brought to Earth. They warn that even a tiny alien microorganism could have unpredictable effects on Earth's ecosystems. By using robotic handling systems on the Moon, researchers hope to eliminate the risk of accidental exposure or release.
Glycosylation in Alzheimer's disease
No abstract
The Price of Care: Trends in Financial Transfers to Aging Parents
CONCLUSIONS AND IMPLICATIONS: Families continue to shoulder a substantial share of aging-related care expenses, with financial burdens disproportionately concentrated among households providing intensive caregiving and those with fewer economic resources. These findings underline the hidden costs of population aging that are borne inequitably across socioeconomic status and signal the need for policy solutions that mitigate the financial burden on families supporting aging parents.
Cerebral Microvascular Injury and Physical Function in Older Patients With Atrial Fibrillation: Evidence for Sex-Specific Patterns
CONCLUSIONS AND IMPLICATIONS: In older memory clinic patients, AF was associated with sex-specific CSVD patterns: greater WMH burden in men and more microbleeds in women. WMH substantially mediated AF-related decline in physical performance, particularly in men, suggesting that CSVD is an important pathway linking AF to physical dysfunction. These findings underscore the need for sex-specific risk stratification and highlight CSVD as a therapeutic target to preserve physical function in patients...
Exercise Effects on Inflammatory Markers in Middle-Aged and Older Adults: A Network Meta-Analysis
CONCLUSIONS AND IMPLICATIONS: Customized structured exercise effectively reduces age-related low-grade inflammation, especially aerobic and resistance training. These results offer actionable insights for clinicians and policymakers working to improve health outcomes in older adults.
Mechanism and regulation of programmed cell death in aging-related diseases
Aging and its associated diseases are characterized by a complex interplay of cellular dysfunction, chronic inflammation, and tissue degeneration. Dysregulated cell death and the resulting inflammatory responses are pivotal drivers of this pathological synergy. Among various cell demise pathways, programmed cell death (PCD) mechanisms, including apoptosis, necroptosis, and pyroptosis, are critical for maintaining homeostasis but can drive pathology when aberrantly activated. Crucially, they...
Aging of Mesenchymal Stem Cells in Bone Aging: Mechanisms, Impact, and Therapeutic Perspectives
Aging of the skeleton is a hallmark of organismal decline and underlies prevalent age-related disorders such as osteoporosis and osteoarthritis. Bone marrow-derived mesenchymal stem cells (BMSCs), the primary source of osteoblasts, undergo profound functional deterioration during senescence, leading to an imbalance between bone formation and resorption. This review systematically summarizes the key features of BMSC senescence, including impaired proliferation and differentiation, epigenetic...
From organ age gaps to precision geromedicine: multi-omic and imaging frameworks for heterogeneous biological aging
Biological aging is increasingly understood as a heterogeneous, multi-system process marked by organ-level vulnerability, cross-organ coordination, and variation in resilience. Advances in plasma proteomics, metabolomics, imaging, DNA methylation, digital biomarkers, and genetic epidemiology have enabled organ-level, system-level, and cross-organ age models, but these measures are often interpreted more strongly than the evidence permits. In this Review, we synthesize evidence on biological age...