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Hiding in plain sight: uncovering the genetic basis of complex phenotypes through low-risk groups

19 hours 57 minutes ago
Medical genetic studies focus on high-risk groups to enrich for targeted phenotypes. Although genetic effects may vary across the lifespan, age-related enrichment of target phenotypes can also arise from cumulative environmental exposures, without requiring changes in genetic architecture. Accumulating environmental effects over the lifetime can inflate nongenetic variance, creating the illusion of greater genetic signal while in fact masking underlying genetic effects. We propose investigating...
Ana I Vazquez

Spatiotemporally homogeneous crystallization for ambient scalable perovskite photovoltaics

19 hours 57 minutes ago
Commercializing perovskite solar cells (PSCs) will likely require the scalable deposition of homogeneous perovskite films under ambient conditions. However, the spatially heterogeneous degradation of metastable perovskites during prolonged coating leads to nonuniformity. Here, we demonstrate spatiotemporally homogeneous crystallization of α-phase FAPbI(3) (where FA is formamidinium) enabled by a phase-locking strategy that establishes a dynamically evolving, moisture-buffering intergranular...
Binlou Gao

Restored clearance of senescent neutrophils by tissue-resident macrophages limits organ aging

19 hours 57 minutes ago
Aging disrupts tissue homeostasis across organ systems. Here, we identify tissue-resident macrophages (TRMs) as central coordinators of age-related organ decline through impaired clearance of senescent neutrophils, a process regulated by the immunomodulatory prostaglandin E2 (PGE(2)) receptor EP2. Reducing TRM EP2 signaling in aged mice preserved youthful mitochondrial fitness and prevented cognitive decline, frailty, sarcopenia, adiposity, cardiac impairment, and systemic inflammation. Plasma...
Yuting Jessy Tan

Choose Home: Veteran and Caregiver Perspectives on the Acceptability of a Novel Short-Term Home Care Program

19 hours 57 minutes ago
CONCLUSIONS: Choose Home was highly acceptable to Veterans and caregivers, who perceived improvements in health, self-management, and caregiving self-efficacy. By filling a gap between acute and longitudinal services, Choose Home may strengthen efforts to deliver whole-person, home-based care. Continued implementation and rigorous evaluation are warranted to assess long-term outcomes and scalability within VA and beyond.
Rebecca J Howe

Circular RNAs-Stress Granule Interplay Drives Aging-Related Proteostasis Loss

19 hours 57 minutes ago
Aging involves a gradual loss of cellular balance, leading to reduced function and increased disease risk. While impaired proteostasis is a key hallmark of aging, more evidence shows the importance of RNA homeostasis (ribostasis), particularly the regulation of circular RNAs (circRNAs). CircRNAs are stable RNA molecules that build up over time and are linked to age-related cellular dysfunctions. In this regard, Kim et al. 2026 provide new insights into the impact of circRNA turnover on aging and...
José M Izquierdo

Regulatory T cell immunosuppressive function requires chaperone-mediated autophagy

19 hours 57 minutes ago
Regulatory T cells (Tregs) are essential for maintaining immune tolerance. We recently identified chaperone-mediated autophagy (CMA), a selective lysosomal degradation pathway, as a critical regulator of Treg function. Treg activation induces CMA, but this response is markedly diminished with aging. Mice lacking CMA specifically in Tregs develop systemic inflammation, impaired immune tolerance and reduced lifespan. We confirm that CMA is a fundamental mechanism supporting Treg suppressive...
Ranee Harrison

Genetic evidence links hypertension to accelerated brain aging

19 hours 57 minutes ago
Hypertension affects one-third of adults and is a major comorbidity of neurocognitive disorders. The causal relationship, shared genetic architecture, and upstream mechanisms linking hypertension to brain aging remain unclear. Hypertension GWAS datasets from MVP and FinnGen R12 were meta-analyzed as the exposure, and a European-ancestry brain age gap (BAG) GWAS derived from the UK Biobank and LIFE-Adult cohorts was used as the outcome. MR and GSMR assessed causality. LDSC, HDL, and S-LDSC...
Xiaoyang Zhu

High-velocity resistance training improves the force-velocity profile in middle-aged and older adults

19 hours 57 minutes ago
The main goal of the present study was to examine the effects of a high-velocity resistance training (HVRT) program on the force-velocity (F-V) profile of different groups of aging adults. An additional aim was to explore whether individual baseline F-V profiles were associated with training-induced improvements in muscle power and functional capacity. Middle-aged and older adults with and without mobility limitations (n = 36, 61 ± 13 years) completed a 12-week HVRT program (2 days/week, 40-60%...
Gustavo Z Schaun

Personality disorders and related healthcare use among older United States veterans experiencing housing instability and homelessness, 2016-2024

19 hours 57 minutes ago
Veterans are vulnerable to housing instability and/or homelessness (HUH) and may encounter unique challenges that affect their healthcare. While research has noted connections between major psychiatric disorders and HUH, few studies have examined personality disorders (PD) and their sex-specific relationships with HUH and healthcare use among aging veterans. We examined sex differences in the epidemiology of PD and their impact on healthcare service use among aging HUH veterans. A...
Hind A Beydoun

Imaging the neurohiv brain in animal models: past, present, and future-toward longitudinal, whole-brain aging phenotypes

19 hours 57 minutes ago
Animal models are essential for defining mechanisms of HIV-associated brain injury in the antiretroviral therapy era, where neurocognitive impairment and brain aging have replaced opportunistic infections as dominant clinical concerns. Humanized mice, EcoHIV murine systems, and SIV or SHIV nonhuman primates now enable increasingly sophisticated brain imaging across in vivo and ex vivo scales. Structural and diffusion MRI, perfusion imaging, manganese-enhanced MRI, and multiphoton and endoscopic...
Paddy Ssentongo

The Construct Validity of the Life-Space Assessment in the Canadian Longitudinal Study on Aging (CLSA)

19 hours 57 minutes ago
CONCLUSION: The LSA can be used to differentiate between known groups. However, there is limited evidence of its convergent validity as its relationship with other measures of actual mobility, perceived mobility, and locomotor capacity for mobility was weak. Future studies need to assess the convergent validity of the LSA against different comparator measures before its use among community-dwelling Canadians.
Selina Malouka