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Sitting up straight may improve your mood and decision-making
A simple change in posture may subtly affect how people feel and make decisions. Participants who sat upright reported greater feelings of pride and took more successful risks in a virtual balloon game than those who hunched over. Most did not realize researchers had influenced their posture, helping rule out the possibility that they were merely responding to expectations. The results suggest workplace ergonomics could influence more than physical comfort.
Scientists discover the brain cells that keep you motivated
A group of brain cells called orexin neurons appears to help us keep working when reaching a reward becomes increasingly difficult. Blocking their activity weakened motivation in rats, pointing to a possible new target for understanding why people sometimes struggle to sustain goal-directed behavior.
Astrophysicists find best evidence yet that galaxies get some spin before birth
New study spots “primordial spin” imprinted on galaxies by churning halos of dark matter
Neanderthal growth gene turns modern humans into muscle heads
People with DNA variant from our evolutionary cousins tend to have more lean muscle mass
COVID-19 can wake up dormant viruses in the body, large study confirms
Virus reactivations by SARS-CoV-2 could worsen initial symptoms and increase risk of Long Covid
A reproducible three-dimensional model of human brain tissue to investigate physiological and disease-associated microglia phenotypes
Stem-cell-based in vitro models offer promising potential to elucidate human brain cell functions and interactions, but limitations in reproducibility, maturation and cell-type diversity persist. Especially, prolonged incorporation of mature microglia and studies of neuroinflammation have proven challenging. Here, we developed a human induced pluripotent stem cell-based three-dimensional cortical brain tissue model (3BTM) containing neurons, astrocytes and microglia with high reproducibility,...
Losing sleep over glia: new mechanisms for Alzheimer-related sleep disruption
No abstract
XunZi, an AI biologist, reveals disease-modifying targets
Hypothesis generation in biomedicine is constrained by human cognitive limitations in synthesizing insights from fragmented biomedical knowledge and multimodal data sources. Here we introduce XunZi, an AI biologist that integrates logical reasoning and multimodal data fusion to autonomously generate de novo therapeutic target hypotheses with testable mechanisms. XunZi has been trained on 24.4 million publications and 613.6 TB of multisource data spanning 21,008 human genes and 5,850 diseases,...
Could mending damaged DNA prolong life?
No abstract