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The bone marrow (BM) microenvironment plays a crucial role in regulating hematopoiesis, yet the molecular changes associated with aging in humans remain poorly understood. Using single-cell RNA sequencing, we uncovered transcriptional shifts in BM endothelial cells (EC) and mesenchymal stromal cells (MSC) during aging. Aged sinusoidal EC exhibited a prothrombotic phenotype with compromised mitochondrial and vascular function. Additionally, we identified a novel arterial EC subset, emerging in...

As global life expectancy rises, age-related musculoskeletal decline poses a growing public health challenge-impairing mobility, increasing frailty, and diminishing quality of life for billions worldwide. Functional deterioration often begins in midlife, yet effective early interventions remain limited. Metformin, a widely prescribed antidiabetic drug, has shown geroprotective potential. However, its capacity to preserve musculoskeletal health during early aging remains poorly defined....

With the global rise in aging populations and age-related diseases, the demand for safe and effective aging modulatory interventions is steadily increasing. Although several clinical drugs have shown aging modulatory potential, their long-term efficacy and safety remain major concerns. Plant-derived polysaccharides, known for their ability to modulate multiple longevity-related signaling pathways, have emerged as promising natural candidates due to their high biocompatibility and low toxicity....

Captive non-human primates are widely used as models of aging, yet the conditions they live in differ markedly from their natural environment. Such environmental differences may influence how the cardiovascular system changes with age. This study characterized age-related cardiac phenotypes in free-ranging rhesus macaques and compared these patterns to captive-housed macaques to assess the influence of environment on cardiac structure and function across the lifespan. We performed transthoracic...

Normal aging is accompanied by declines in executive function, and regular physical exercise has been proposed as a protective factor. However, the neural correlates linking long-term habitual exercise to executive efficiency in older adults remain unclear. This study combined resting-state functional magnetic resonance imaging (rs-fMRI) with behavioral assessments to examine whether long-term habitual exercise is associated with executive performance and resting-state neural organization in...

CONCLUSIONS: PCPs reported that they would often initiate opioid deprescribing conversations with older adults, but were less confident in managing older adults with signs of OUD. PCPs require additional support to implement successful conversations on opioid deprescribing with older adults.

We previously demonstrated that flattening circadian glucocorticoid (GC) rhythmicity without increasing overall GC exposure induces an osteoporotic phenotype in mice. Here, we aimed to further elucidate the importance of the amplitude and timing of circadian GC oscillations for bone health. C57Bl/6J mice were implanted with vehicle or corticosterone slow-releasing pellets to flatten the circadian GC rhythm. To differentiate between the importance of circadian GC peaks or troughs, mice with...

Handwriting is a complex cognitive and motor skill supported by a distributed brain network involving cortical, subcortical, and cerebellar regions responsible for planning, execution, and sensorimotor integration. Beyond its communicative role, handwriting provides biologically meaningful information about brain function and motor control, serving as a sensitive marker of both normal and pathological changes. Age-related alterations, such as reduced fine motor precision, impaired sensory...

Noise exposure is a known cause of hearing loss, and only a few effective preventive drugs are available. Therefore, in this study, we aimed to investigate the protective effects of brimonidine on noise-induced inner ear hearing impairment in mice and explore its underlying mechanisms and long-term outcomes. Mice were randomly divided into control, noise exposure, and brimonidine groups. A 62-week follow-up was conducted after noise exposure. Brimonidine inhibited the noise-induced increase in...

Science, Volume 392, Issue 6794, April 2026.

Science, Volume 392, Issue 6794, April 2026.

Science, Volume 392, Issue 6794, April 2026.

Science, Volume 392, Issue 6794, April 2026.

Science, Volume 392, Issue 6794, April 2026.

Science, Volume 392, Issue 6794, April 2026.

Science, Volume 392, Issue 6794, April 2026.

Science, Volume 392, Issue 6794, April 2026.

Science, Volume 392, Issue 6794, April 2026.