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Pericyte K<sub>ATP</sub> channel hyperactivity redistributes cortical blood flow in a CADASIL mouse model
Cerebral hemodynamic dysfunction is a key driver of unhealthy brain aging. Impaired microcirculatory reactivity leads to uneven perfusion, rendering deeper brain regions more vulnerable and thereby contributing to cognitive decline. Yet how capillaries contribute to these deficits remains poorly defined. Here we combined spatial transcriptomics with in vivo two-photon and three-photon imaging to measure layer-specific cerebral blood flow in control and small vessel disease model mice (CADASIL...
Post-mitotic cardiomyocyte senescence redefines cardiac ageing
No abstract
Evaluation of Hospital Readmission and Mortality Risk in Older Frail Patients Using the FIB-4 Index: A Cohort Study
CONCLUSIONS: FIB-4 appears to reflect reduced biological reserve and systemic vulnerability rather than isolated liver dysfunction. As a cost-free parameter derived from routine blood tests, FIB-4 may represent a practical tool for risk stratification in hospitalized frail older adults.
Memory training through Chinese classics recitation for individuals with subjective cognitive decline: study protocol for a pilot study
BACKGROUND: Subjective cognitive decline (SCD) is a preclinical condition associated with an increased risk of dementia and Alzheimer's disease, with no consensus regarding effective therapeutic interventions to date. As the global burden of aging-related neurodegenerative diseases continues to rise, early intervention has become increasingly critical. Cognitive training has been proposed as a promising behavioral intervention; however, few studies have integrated multimodal assessments to...
<em>Caenorhabditis elegans</em> in neuroscience: from neural communication to neurodegenerative disease modeling
Consistent with humans and other metazoans, the nematode Caenorhabditis elegans (C. elegans) undergoes progressive structural and functional decline during aging. Possessing highly conserved genetic pathways that share extensive homology with human genes, and characterized by a streamlined, fully mapped connectome, C. elegans has emerged as a robust model for dissecting the mechanisms underlying neuronal aging and degeneration. In this review, we summarize the intrinsic advantages of C. elegans...
Correction: Tactile sensation moderates the association between hand dexterity and higher-level cognition in older adults with and without MCI
[This corrects the article DOI: 10.3389/fnagi.2026.1833368.].
Targeting the NO-cGMP axis in age-related vascular dysfunction: a systematic review and meta-analysis of preclinical animal studies
Vascular dysfunction in aging is driven by multiple interconnected hallmarks of aging, including DNA damage, oxidative stress, chronic inflammation, mitochondrial dysfunction, and cellular senescence and features by endothelial impairment, inflammation, and reduced nitric oxide-cyclic guanosine monophosphate (NO-cGMP) signaling. Targeting this pathway may offer therapeutic benefit beyond traditional atherosclerosis-focused treatments. A systematic review and meta-analysis were conducted...