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Construction and mining firms are rolling out devices that track workers’ fatigue. Critics say the tech could be misused by authorities

Science, Ahead of Print.

Scientists are advancing a promising new way to fight antibiotic-resistant infections by using viruses that specifically target and kill harmful bacteria. An international team has released the first coordinated guidelines for personalized phage therapy, offering a roadmap for safely bringing this experimental treatment into clinical practice. Early findings are encouraging, with one study reporting improvement in 77% of patients and the disappearance of targeted bacteria in 61%.

Largest analysis to date of the impact of humanmade sounds finds harm across a variety of ecosystems

Novel technique for cooling atomic gases could make it easier to probe Einstein’s theory of gravity

Scientists have discovered a compound that transforms a natural muscle-repair protein into a more powerful version dubbed "Super HGF," more than doubling its ability to bind to a key receptor while protecting it from age-related chemical damage. The breakthrough, supported by early mouse experiments, could eventually help combat muscle loss and preserve strength as people age.

Scientists propose that the brain’s mysterious cross-wiring, which connects each hemisphere to the opposite side of the body, may have originated more than 500 million years ago in the visual systems of ancient fish. Rather than evolving for a specific advantage, this unusual arrangement may simply be a legacy of evolution building new brain circuits on an ancient foundation.

A new study warns that permanent daylight saving time could force American children to make at least 2 billion additional school commutes in darkness, potentially increasing safety risks and disrupting their biological clocks. Researchers found that fatal crashes involving school-aged pedestrians were roughly twice as likely during dark mornings as after sunrise.

Congress and the White House are moving to weaken key law that requires preproject reviews

While the accumulation of Aβ peptides, derived by proteolytic cleavage from the amyloid precursor protein APP, constitutes a hallmark of Alzheimer's disease, the question of whether endogenous, physiological APP processing serves an essential role for normal brain function(s) has remained elusive. Here, we modified the mouse APP locus to delete the endogenous α- and β-secretase sites (APP residues S592-G621) while preserving the transmembrane topology and the APP C-terminus. These novel knockin...

The apolipoprotein E (APOE) gene is the strongest genetic risk factor for Alzheimer's disease (AD), influencing amyloid-β (Aβ) aggregation, clearance, and glial function. While APOE4 promotes Aβ pathology and APOE2 is protective, how these opposing alleles interact in the heterozygous APOE2/4 state remains unknown. Here, using littermate-controlled heterozygous APOE mice (APOE2/3, APOE3/4, and APOE2/4) alongside APOE3/3 controls crossed with 5xFAD mice, we show that APOE3/4 mice exhibit...

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Parkinson's disease (PD) is a growing public health challenge as populations age. Current diagnosis relies on motor symptoms and invasive procedures, making early detection difficult. Here we present Quest2Dx, a generalized artificial intelligence model that analyzes health questionnaires to enable low-cost, non-invasive PD screening. Conventional models are built for each questionnaire, and missing responses degrade their performance. Quest2Dx uses language modeling to encode the meaning of...

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