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States hail decision, but White House may try other ways to end funding

A protein called SORLA may act as a powerful defense against the toxic tau tangles involved in Alzheimer’s disease. Mice with extra SORLA had less tau accumulation, less brain atrophy, and healthier connections between neurons, while mice without it experienced more severe damage. The findings also revealed a possible drug target that could help control harmful activity in supporting brain cells.

Critics say Trump’s real goal is to sow doubts about 2030 census and add Republican seats in Congress

Scientists have redesigned zinc oxide particles to create a mineral sunscreen that protects against ultraviolet radiation without leaving such a noticeable white cast. The SPF 30 formula could make sunscreen easier and more appealing to use across a wider range of skin tones.

The mysterious sound known as The Hum has been reported worldwide for decades, yet its source often remains impossible to find. Researchers tested whether people who hear it have exceptional low-frequency hearing or measurable sounds produced inside their ears, but neither explanation fit most participants. The strongest possibility is that many cases involve low-frequency tinnitus, even though the sound seems completely external.

Aging is characterized by progressive loss of proteostasis, and heat shock transcription factor 1 (HSF1) is the master regulator of the cellular stress response, making it an attractive pharmacological target for interventions aimed at extending lifespan. However, a systematic synthesis of phytochemicals that modulate HSF1 has been lacking. Following PRISMA 2020 guidelines, we systematically searched PubMed, Web of Science, Scopus, Embase, and the Cochrane Library from March 2016 to March 2026,...

Aging is commonly framed as a progressive accumulation of cellular and tissue-level damage. However, the aged organism does not decline as a collection of isolated organs. Aging is communicated systemically through blood-borne signals that connect senescent cells, immune remodeling, vascular dysfunction, metabolic stress, dysbiosis, and chronic inflammation. I propose the concept of the circulating senosome to describe the composite network of age-associated circulating mediators, including...

Aging is characterized by progressive loss of proteostasis, and heat shock transcription factor 1 (HSF1) is the master regulator of the cellular stress response, making it an attractive pharmacological target for interventions aimed at extending lifespan. However, a systematic synthesis of phytochemicals that modulate HSF1 has been lacking. Following PRISMA 2020 guidelines, we systematically searched PubMed, Web of Science, Scopus, Embase, and the Cochrane Library from March 2016 to March 2026,...

Scientists may have uncovered one reason coffee is repeatedly associated with healthier aging and lower disease risk. Compounds in coffee appear to activate NR4A1, a receptor that helps protect cells from stress, inflammation, and damage. These protective effects disappeared when the receptor was removed, strengthening the connection. Surprisingly, plant-based compounds such as caffeic acid seemed far more active than caffeine itself.

A low-cost antidepressant may offer new hope for people struggling with long COVID fatigue. In a randomized clinical trial involving 399 adults, fluvoxamine significantly reduced fatigue and improved quality of life compared with a placebo, making it one of the first medications to show meaningful benefits for this disabling condition.

Several popular sugar substitutes may not be as harmless as they seem. Adults who consumed the most artificial sweeteners showed substantially faster declines in memory and thinking, especially if they were under 60 or had diabetes. The highest intake was linked to cognitive aging roughly 1.6 years faster than the lowest intake. Researchers stressed that more studies are needed before concluding that sweeteners are the cause.

A 12-week intermittent fasting program produced weight-loss benefits that were still visible a year later. Participants who ate within an eight-hour window maintained more weight loss than those who followed their usual longer eating schedule. Both early and late eating windows worked, while early fasting appeared especially helpful for preserving fat loss.

Alzheimer's disease (AD) is a common age-related neurodegenerative disorder (NDD), with ageing as its primary risk factor. Cellular senescence, characterized by permanent cell-cycle arrest, apoptosis resistance and acquisition of the senescence-associated secretory phenotype (SASP), is the cellular hallmark of ageing. Recent evidence indicates that blood-brain barrier (BBB) dysfunction precedes cognitive decline and pathological protein deposition, representing an early event in AD, with the...

Age-related disease burden accumulates heterogeneously from later midlife to older age, but the biology underlying these divergent trajectories is poorly understood. We analysed 7199 adults aged 40 years and over in the Tsuruoka Metabolomics Cohort Study, Japan, with baseline fasting plasma metabolomics (94 metabolites measured by capillary electrophoresis-mass spectrometry) and linked health insurance claims. Monthly cumulative Charlson Comorbidity Index scores were constructed from aligned...

Chloride is the most abundant anion within lysosomes and plays a pivotal role in regulating lysosomal physiology and function. However, the mechanisms governing lysosomal chloride homeostasis remain largely elusive. Here, we identified TTYH3 as a regulator of lysosomal chloride permeability. TTYH3 mediates chloride efflux from the lysosomal lumen and enhances TRPML1-mediated lysosomal calcium release. Overexpression of TTYH3 results in markedly enlarged lysosomes by promoting lysosomal fusion...

Chemoresistance in pancreatic ductal adenocarcinoma (PDAC) is partly driven by pathological stromal remodeling, yet the underlying mechanisms remain poorly understood. Here, we show that gemcitabine treatment induces tumor cell senescence and activates cancer-associated fibroblasts via the senescence-associated secretory phenotype, leading to progressive fibrotic matrix stiffening. This biomechanical reprogramming engages the mechanosensitive ion channel Piezo1, triggering metabolic rewiring...

Alzheimer's disease (AD) is a common age-related neurodegenerative disorder (NDD), with ageing as its primary risk factor. Cellular senescence, characterized by permanent cell-cycle arrest, apoptosis resistance and acquisition of the senescence-associated secretory phenotype (SASP), is the cellular hallmark of ageing. Recent evidence indicates that blood-brain barrier (BBB) dysfunction precedes cognitive decline and pathological protein deposition, representing an early event in AD, with the...

CONCLUSIONS: Physical activity is closely associated with lower health inequality among older adults in China, especially among physiologically vulnerable and socioeconomically disadvantaged groups. Policies promoting accessible community-based physical activity may help improve health equity in aging populations.

ObjectivesSibling ties are among the most enduring of all social relationships, so the loss or absence of this long-standing bond may undermine the well-being of older adults. This study examined whether and how disconnectedness from adult siblings (i.e., no contacts/interactions and emotional distance) is linked to older adults' cognitive functioning.MethodsWe use data from four waves of the Wisconsin Longitudinal Study (1993-2020) and structural equation models to prospectively evaluate the...