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White House budget director calls the National Center for Atmospheric Research a source of “climate alarmism”

Data detectives see validation in deal with U.S. government that penalizes Dana-Farber Cancer Institute for misrepresenting data in NIH grant applications

Following Senate confirmation, billionaire Jared Isaacman will lead a diminished workforce

Thousands of earthquakes yield best picture yet of core-mantle boundary, shedding light on deep flows of viscous rock

“Powerful” method for studying evolution could help researchers understand how species developed specialized eyes

China’s rapidly aging population and evolving socio-economic landscape, particularly shifting gender roles, are reshaping traditional caregiving dynamics. However, limited research has examined the associations between caregiver gender and the functional and psychological health of older parents, particularly in the context of gender matching between caregivers and care recipients. This study addresses this gap by utilizing four waves of CLHLS data, employing a Logit model for estimation, and...

Alzheimer's Disease (AD) is a progressive neurodegenerative disorder characterized by cognitive decline and memory loss. In 2024 it affected approximately 1 in 9 people aged 65 and older in the U.S., 6.9 million individuals. Early detection and accurate AD diagnosis are crucial for improving patient outcomes. Magnetic resonance imaging (MRI) has emerged as a valuable tool for examining brain structure and identifying potential AD biomarkers. This study performs predictive analyses by employing...

Alzheimer's disease (AD) is a significant neurological condition that is marked by the gradual decline of memory and cognitive function, with a higher incidence observed in older individuals. The mental deterioration associated with this condition is irreversible, resulting in substantial consequences for both affected individuals and society as a whole. Despite relentless research efforts, a definitive cure for AD remains elusive. However, interventions targeting the early stages of the disease...

Single-cell multiomics provides critical insights into how disease-associated variants identified through genome-wide association studies (GWASs) influence transcription factor eRegulons within a specific cellular context; however, the regulatory roles of genetic variants in aging and disease remain unclear. Here, we present scMORE, a method that integrates single-cell transcriptomes and chromatin accessibility with GWAS summary statistics to identify cell-type-specific eRegulons associated with...

The significance of DNA hydroxymethylation in replicative senescence of mesenchymal stem cells (MSCs) and aging-related osteoporosis remains unknown. Here, we reveal 5hmC levels positively regulate MSC self-renewal and osteoblast differentiation. Mechanistically, PARP1 recruits TET1 to hydrolyze methylated nucleotides on DNMT1 exons, aiding CTCF in preventing DNMT1 alternative splicing in early MSCs. Additionally, ATM phosphorylates TRIM37 at Th203, promoting its nuclear entry and the...

Epigenetic Clocks have been trained to predict chronological age, healthspan and lifespan. Such clocks are often analysed in relation to disease outcomes - typically using small datasets and a limited number of clocks. Here, we present a large-scale (n = 18,859), unbiased comparison of 14 widely used clocks as predictors of 174 incident disease outcomes and all-cause mortality over 10-years of follow up. Second- and third-generation clocks significantly outperform first-generation clocks, which...

The central nervous system, comprised of the brain, spinal cord, and nerves, includes the autonomic nervous system (ANS) that regulates involuntary functions. Within the ANS, the sympathetic and the parasympathetic nervous systems (SNS and PNS, respectively) control the same bodily functions, but in opposing directions. For example, the sympathetic nervous system elicits our "fight or flight" response, while the parasympathetic system supports "rest and repair" mechanisms in the broadest...

N6-methyladenosine (m⁶A) is the most prevalent RNA modification and plays diverse roles in mammalian cells. However, its significance in human trophoblast lineage commitment and placenta development remains poorly understood. Here we show that METTL3, the primary enzyme responsible for m⁶A depositions, specifically marks cytotrophoblasts in human placenta, and exhibits defective expression in cytotrophoblasts from preeclampsia patients. Through in-depth in vitro investigation, we identify...

Battery health often evolves from an initial regime of slow capacity decay to a fast decay regime, due to catastrophic electrochemical reactions to cause the battery failure. The signals of such failure, however, often emerge much earlier during cycling, an early detection of which may help prevent the failure through real-time adjustment of cycling procedures. Here we demonstrate the integration of machine learning module directly into electrochemical battery test stations to constantly detect...

Senescent cells, characterized by a state of irreversible proliferative arrest and inflammatory profile, have emerged as drivers of age-related decline. Growing evidence suggests that alterations in mitochondrial function and morphology play a key role in the induction and maintenance of senescence, as well as in promotion of the proinflammatory senescence-associated secretory phenotype (SASP). In this review, we seek to survey the relationship between mitochondrial dysfunction and senescence,...

Single-cell multiomics provides critical insights into how disease-associated variants identified through genome-wide association studies (GWASs) influence transcription factor eRegulons within a specific cellular context; however, the regulatory roles of genetic variants in aging and disease remain unclear. Here, we present scMORE, a method that integrates single-cell transcriptomes and chromatin accessibility with GWAS summary statistics to identify cell-type-specific eRegulons associated with...

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CONCLUSIONS: Cumulative risks during the COVID-19 pandemic escalated, with pandemic responses such as lockdowns increasing the adverse effects of social isolation and loneliness on positive affect of very old adults. Our pooled-multi-sample design allows a quantitative investigation of an understudied population, offering researchers new insights and an empirical strategy to utilize.