Skip to main content

Aggregator

Brain senescence drives sarcopenia-like transcriptomic remodeling in skeletal muscle

5 days 23 hours ago
Aging is accompanied by a progressive decline in skeletal muscle mass and function, culminating in sarcopenia, a major contributor to frailty, disability, and mortality in older adults. While skeletal muscle aging has traditionally been attributed to cell-autonomous and local tissue mechanisms, increasing evidence suggests that systemic, cell non-autonomous processes play a central role in coordinating aging across organs. The brain, particularly the hypothalamus, has emerged as a key regulator...
Shoba Ekambaram

A Person-Centered Exploration of Mental and Cognitive Health Risk Profiles in Community-Dwelling Older Adults

5 days 23 hours ago
IntroductionThis study extends prior work by identifying multidimensional profiles of co-occurring mental health and cognitive symptoms that better reflect the complexity of aging and identify high-risk subgroups with more severe symptom profiles.MethodsThis secondary analysis used Wave II data from the National Social Life, Health, and Aging Project (NSHAP). Latent profile analysis was conducted to identify distinct symptom profiles and examine associated sociodemographic, clinical, and...
Se Hee Min

Skin Aging and Mitochondrial Dysfunction: Structural Changes, Mechanistic Insights, and Therapeutic Perspectives

5 days 23 hours ago
This narrative review discusses the relationship between structural changes in the skin and mitochondrial function during aging and evaluates emerging therapeutic interventions targeting mitochondrial dysfunction. An analysis of 49 scientific articles published between 2015 and 2025 was conducted using descriptors including "skin aging," "mitochondrial dysfunction," "oxidative stress," and "cutaneous senescence," and articles were retrieved from PubMed, Scopus, and ScienceDirect. Additional...
Nathália Cardoso de Afonso Bonotto

Mapping the network structure of dementia and its associated factors among older adults in Singapore: evidence from two national cross-sectional studies

5 days 23 hours ago
CONCLUSIONS: This study highlights the complex web of interrelations linking dementia with social, behavioural, and health-related factors in later life. Rather than implying causal direction, these findings illustrate how multiple factors cluster and coexist within older adults' lives. These interconnections may inform the design of holistic strategies that integrate employment opportunities, physical activity promotion, social participation, sleep health, and cerebrovascular prevention into...
Ke Ning