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Thermally evaporated perovskite/silicon tandems via formamidinium eutectic
Solution processing remains the dominant route to high-performance perovskite/silicon tandems, but it remains challenging to simultaneously achieve industrial scalability and long-term reliability^(1-3). Thermal evaporation is more industrially viable, yet it has not been successfully demonstrated for large-area perovskite/silicon tandems, largely due to the thermal degradation of formamidinium iodide (FAI) during high-temperature evaporation. Here we synthesize a formamidinium-based eutectic...
Late-life semaglutide treatment slows ageing and extends lifespan in female mice
Pharmacological glucagon-like peptide-1 receptor (GLP-1R) activation reduces food intake and is an effective therapy for type 2 diabetes and obesity¹. The use of GLP-1 medicines has revealed pleiotropic beneficial effects beyond glucose and weight control^(2-5), but little is known about the underlying basis of the pleiotropic effects. Here, treatment of 20-month-old female C57BL/6 mice with the GLP-1R agonist semaglutide for 3 months improved physiological function, attenuated hallmarks of...
Targeting cellular senescence mitigates chemotherapy-induced bone loss in young and aged mice
Chemotherapy-induced bone loss represents a major clinical challenge, particularly in aging populations, yet the contribution of cellular senescence to this process and its therapeutic potential remain incompletely understood. Here, we investigated the role of chemotherapy-induced cellular senescence in mediating skeletal deterioration following chemotherapy and evaluated the therapeutic potential of senolytic treatment. Young (3-month-old) and aged (20-month-old) male and female mice were...
PCSK9 inhibition attenuates alcohol-induced cardiovascular dysfunction and links hepatic lipid accumulation to impaired myocardial contractile reserve
Excessive alcohol consumption accelerates cardiovascular aging by promoting oxidative stress, inflammation, lipid dysregulation, fibrotic remodeling, and loss of ventricular-vascular reserve. PCSK9, a key regulator of cholesterol metabolism, has emerged as a mediator of age-related cardiovascular dysfunction and alcohol-associated liver and neurovascular injury. We investigated whether PCSK9 inhibition protects against alcohol-induced cardiovascular dysfunction and associated cardiac-hepatic...
Reframing the epidemiological transition as increasing returns to tackling aging-related diseases
Global life expectancy has risen since 1973 from 58 to over 73 years, while the share of people aged 65 years and older has doubled to 10% and is projected to reach 21% by 2073. This shift is linked to an epidemiological transition from infectious to chronic disease. Here, using Global Burden of Disease data, we reframe this transition by statistically grouping diseases on the basis of their impact over the life cycle, yielding four clusters: infant, early-adult, later-adult and aging-related....
Sex-specific control of locomotor behavior by neuronal Arhgef10 in aged Drosophila
Mutations and polymorphisms in the Rho guanine nucleotide exchange factor 10 (ARHGEF10) locus are associated with behavioral and locomotor dysfunctions in humans, including psychiatric disorders and polyneuropathies that show age- and sex-specific prevalence. ARHGEF10 encodes a conserved guanine exchange factor that activates Rho GTPases and has proposed roles in cell migration and adhesion, but the relevant cell types and mechanisms underlying its age- and sex-dependent effects remain unclear....
Nations expanding their research programmes impose sweeping penalties for malpractice
Magic-mushroom compound blocks a severe side effect of chemotherapy in mice
Ketone homologation via palladium-catalysed decarboxylative rearrangement
A consensus roadmap from the SENESCENCE2030 network towards precision senescence medicine
GLP-1 receptor agonism extends median lifespan in mice
Daily briefing: GLP-1 obesity drugs slow signs of ageing in mice
Immune therapy engineered inside the body eases multiple sclerosis
High-capacity associative memory in a quantum-optical spin glass
Science, Ahead of Print.
ADHD may have a surprising creative advantage
Some of the attention patterns that make ADHD challenging may also help spark creativity by allowing the brain to explore more ideas and unexpected connections. Researchers think creative activities could potentially channel this “defocused attention” while helping strengthen the brain systems involved in focus and self-control.
Each extra hour of prolonged sitting linked to 9% higher cancer death risk
Sitting for long, uninterrupted stretches may carry greater health risks than sitting the same amount of time in shorter bouts. Researchers found that each extra hour of prolonged sedentary behavior was associated with a 9% higher risk of cancer death. Breaking up sitting with movement showed the opposite pattern, while replacing an hour of prolonged sitting with light activity was linked to a 12% lower risk.
Dutch news media get hefty fines for ‘promoting’ weight loss drugs
Regulators crack down on stories that were too positive about drugs that target GLP-1
Magic mushroom compound may prevent chemotherapy pain
Research in mice finds that psilocybin protects against nerve damage and sensitivity caused by common cancer drugs
Can AI help solve the peer-review crisis? Here are its promises and pitfalls
Amid a shortage of human reviewers, tests indicate AI can assist—but is not a savior
Can cells genetically engineered in the body fight autoimmune diseases?
New approach that induces patients to make their own CAR-T cells could be faster and cheaper than existing methods