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Trr1 (thioredoxin reductase 1) modulates ERphagy in aging via liquid-liquid phase separation
Aging is associated with the deterioration of various biological processes including disrupted proteostasis and impaired macroautophagy/autophagy. Biomolecules can undergo liquid-liquid phase separation (LLPS) to form biomolecular condensates that exert specific biological functions. Trr1 (thioredoxin reductase 1) is a pivotal enzyme in the thioredoxin antioxidant system. Deletion of TRR1 results in impaired autophagy; however, the underlying mechanism is largely unexplored. In this study, we...
Diosgenin Alleviates Age-Related Sarcopenia by Promoting Satellite Cell Proliferation and Myogenic Differentiation via Activation of the SIRT1/PGC-1α Signaling Pathway
Age-related sarcopenia is characterized by a progressive decline in skeletal muscle mass and function, with satellite cell dysfunction representing a central pathogenic mechanism. Diosgenin, a steroidal saponin derived from plants of the Dioscorea genus, has demonstrated potential anti-aging properties; however, its role in sarcopenia remains unclear. In this study, naturally aged C57BL/6J mice and a D-galactose (D-gal)-induced senescent C2C12 cell model were employed to systematically...
Geriatrics for the 21st Century: Bigger, Bolder, Better
No abstract
Better Sleep Better Psychological Well-Being Among Older Adults: Evidence From the Chinese Longitudinal Healthy Longevity Survey (CLHLS)
CONCLUSION: This study found that better sleep quality was longitudinally associated with better psychological well-being among Chinese older adults over time. The results suggest that enhanced sleep quality among older adults in China is strongly associated with improved psychological well-being.
AI can tell if your brain is aging faster than you are
A person’s sleeping brain may reveal warning signs of dementia long before memory problems begin. Researchers used machine learning to analyze EEG recordings from about 7,000 adults and found that an older-than-expected “brain age” was tied to a sharply higher dementia risk. Every additional 10 years of brain aging raised that risk by nearly 40%.
Brains of male and female mice recover differently from ketamine
Daily Briefing: How smallpox reached the Americas
Scientists using LLMs will ‘do more, less well’, modelling study predicts
The forensic traces that can help catch poachers — July’s best science images
Meat allergy is on the rise — what scientists want to know
The physics of fizz: why some bubbles are louder than others
Briefing Chat: Orcas smashed a sunfish to bits — researchers aren’t sure why
Author Correction: Cucurbituril-based anion-conducting membranes with supramolecular nanopores
How smallpox reached the Americas: first genomic evidence points to Europeans
The power of ignorance and peering into the Milky Way: Books in brief
Scientists discover how obesity may fuel Alzheimer’s disease
Researchers have uncovered a possible biological pathway connecting obesity to Alzheimer’s disease. Obesity appears to raise levels of certain fat molecules that can travel to the brain, disrupt its immune defenses, and promote harmful amyloid buildup. Correcting this fat imbalance improved memory and brain function in Alzheimer’s models.
Scientists find a simple routine linked to less pain and depression
Keeping a regular daily schedule may help reduce pain and depression, especially among older adults with insomnia. Researchers found that consistent times for waking, eating, socializing, and sleeping were linked to better well-being regardless of sleep quality. These routines may strengthen the body’s internal clock and limit the disruptive effects of “social jet lag.”
Rice bran compound may help ease irritable bowel symptoms
A compound in rice bran may help calm an overactive gut by reducing the calcium signals that cause intestinal muscles to contract. Ferulic acid suppressed contractions triggered by several chemical messengers in laboratory experiments. The discovery could eventually support new dietary approaches for diarrhea-related digestive disorders, although it may make constipation worse.
Depression and amyloid-β across CSF, PET, and plasma biomarkers: a systematic review and meta-analysis
Alzheimer's disease is increasingly defined by biomarker evidence of amyloid-β and tau pathology, sharpening questions about whether late-life depression contributes to, or instead reflects, this pathology. We conducted a systematic review and meta-analysis of studies published between 2000 and 2025 that compared amyloid-β biomarkers in adults with and without depression, with depression defined by validated clinical diagnoses or symptom rating scales. Twenty-four studies were included, spanning...
Agentic AI for scaling diagnosis and care in neurodegenerative disease
US healthcare systems are struggling to meet the growing demand for neurological care, particularly in Alzheimer's disease and related dementias. Generative artificial intelligence (AI) built on large language models now enables agentic AI systems that can streamline clinical workflows, integrate multimodal data and learn from practicing specialists. We envision an agentic AI system that scales specialist-level care to nonspecialist clinical settings through a continuously learning healthcare...