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Association between physical resilience and self-perceptions of aging among Chinese community-dwelling older adults: a cross-sectional study
CONCLUSIONS: This study highlights the crucial associations of aging awareness and negative results with PR. Therefore, community medical workers can promote the correct understanding of aging and achieve positive aging by enhancing the physical resilience of the elderly in the community.
Reframing Expectations about aging - Physical Activity and Inclusive Reappraisal (RE-PAIR): Protocol of a randomized intervention promoting positive self-perceptions of aging and physical activity in older couples
CONCLUSION: This project will provide evidence on whether targeting couples could enhance/facilitate promotion of positive self-perceptions of aging and physical activity in older age.
Brain senescence drives sarcopenia-like transcriptomic remodeling in skeletal muscle
Aging is accompanied by a progressive decline in skeletal muscle mass and function, culminating in sarcopenia, a major contributor to frailty, disability, and mortality in older adults. While skeletal muscle aging has traditionally been attributed to cell-autonomous and local tissue mechanisms, increasing evidence suggests that systemic, cell non-autonomous processes play a central role in coordinating aging across organs. The brain, particularly the hypothalamus, has emerged as a key regulator...
A Person-Centered Exploration of Mental and Cognitive Health Risk Profiles in Community-Dwelling Older Adults
IntroductionThis study extends prior work by identifying multidimensional profiles of co-occurring mental health and cognitive symptoms that better reflect the complexity of aging and identify high-risk subgroups with more severe symptom profiles.MethodsThis secondary analysis used Wave II data from the National Social Life, Health, and Aging Project (NSHAP). Latent profile analysis was conducted to identify distinct symptom profiles and examine associated sociodemographic, clinical, and...
Beyond survival: Redefining successful aging in the era of medical complexity
A common misconception is that increasing longevity reflects slower aging. Instead, most longevity gain comes from medical advances that allow survival with disease, rather than changes to the biology of aging itself, challenging how we study aging and health.
Skin Aging and Mitochondrial Dysfunction: Structural Changes, Mechanistic Insights, and Therapeutic Perspectives
This narrative review discusses the relationship between structural changes in the skin and mitochondrial function during aging and evaluates emerging therapeutic interventions targeting mitochondrial dysfunction. An analysis of 49 scientific articles published between 2015 and 2025 was conducted using descriptors including "skin aging," "mitochondrial dysfunction," "oxidative stress," and "cutaneous senescence," and articles were retrieved from PubMed, Scopus, and ScienceDirect. Additional...
Mapping the network structure of dementia and its associated factors among older adults in Singapore: evidence from two national cross-sectional studies
CONCLUSIONS: This study highlights the complex web of interrelations linking dementia with social, behavioural, and health-related factors in later life. Rather than implying causal direction, these findings illustrate how multiple factors cluster and coexist within older adults' lives. These interconnections may inform the design of holistic strategies that integrate employment opportunities, physical activity promotion, social participation, sleep health, and cerebrovascular prevention into...
Cognitive decline and risk of all-cause mortality in older women: a cohort study
CONCLUSION: Cognitive decline over four years was associated with an increased risk of mortality among older women. Further studies should explore whether declines earlier in life or among men are also associated with an increased risk of mortality.