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Alzheimer's tau protein has a surprising secret role in memory

4 days 2 hours ago
Researchers found that tau is essential for turning new experiences into lasting memories by helping organize the brain's memory-storing cells. The mouse study also revealed how abnormal tau may contribute to Alzheimer's by disrupting both the formation of new memories and the recall of existing ones.

This ultrasound treatment may help stop arthritis before it starts

4 days 4 hours ago
A simple, non-invasive ultrasound treatment could one day help injured joints heal instead of remaining trapped in a cycle of damaging inflammation. Researchers at The University of Alabama in Huntsville found that continuous low-intensity ultrasound encouraged key immune cells called macrophages to shift from an inflammatory state toward one that supports tissue repair.

From Gut to Fat: Intestinal Epithelial Exosomes Target PDGFRalpha(+) Progenitors to Promote Lipogenesis and Counteract Subcutaneous Adipose Tissue Atrophy in Aging

4 days 4 hours ago
Age-related subcutaneous adipose tissue (SAT) atrophy is a hallmark of aging, contributing to metabolic dysfunction and systemic aging. The mechanisms underlying SAT atrophy and potential therapeutic strategies remain poorly understood. Here, we report that small intestinal epithelium-derived exosomes (SI-Exos) mediate gut-adipose communication and play a pivotal role in age-related SAT remodeling. We found that the miRNA cargo of SI-Exos undergoes significant age-related changes. Administration...
Tingting Huang

Paid work participation and cognitive function trajectories among older adults in China: evidence from a longitudinal study

4 days 4 hours ago
OBJECTIVES: Evidence on the association between work and cognitive ageing has been mixed, and research from China remains limited, particularly with respect to heterogeneity in cognitive function trajectories. This study examined whether paid work participation in later life is associated with distinct cognitive function trajectories among older Chinese adults.
Ziting Zhao

Epigenetic Aging of Critical Illness Survivors Assessed by the Muscle-Specific "Clock" and Its Relationship With Reduced Long-Term Muscle Strength

4 days 4 hours ago
Critically ill patients requiring treatment in the intensive care unit (ICU) suffer from muscle weakness that persists for years. As compared with healthy subjects, skeletal muscle of patients biopsied five years post-ICU revealed an abnormal transcriptome partially associated with poor muscle strength. We now hypothesized that skeletal muscle of long-term ICU survivors is "epigenetically aged", as determined by a muscle-specific epigenetic clock, and that such accelerated epigenetic aging...
Ceren Uzun Ayar

Scientists discover how the brain rewires itself to truly multitask

4 days 7 hours ago
Practice may do more than make perfect. Researchers found that extensive training physically reorganizes the brain, allowing learned tasks to bypass the prefrontal cortex and run through specialized circuits instead. By freeing the brain's "thinking" center, people became better at performing another task at the same time, challenging the long-held idea that humans only switch rapidly between tasks rather than truly multitask.

Columbia scientists discover surprising link between serotonin and heart valve disease

4 days 11 hours ago
Scientists have uncovered evidence that serotonin, the chemical best known for regulating mood, may also speed the progression of a common heart valve disease in some people. The research suggests that patients with degenerative mitral regurgitation who take SSRI antidepressants and carry a specific genetic variant may develop severe valve damage sooner, potentially requiring surgery at a younger age.

Common blood pressure drug could make cancer therapy far more powerful

4 days 15 hours ago
Researchers found that the common blood pressure drug telmisartan can significantly improve the performance of the cancer drug olaparib, potentially expanding its benefits beyond patients with BRCA-related tumors. The combination is already being tested in human clinical trials after showing strong immune-boosting and anticancer effects in preclinical studies.

Second pregnancy changes the brain in surprising new ways

5 days 3 hours ago
Researchers found that every pregnancy rewires the brain in its own way, with a second pregnancy bringing a different pattern of changes than the first. The discoveries could lead to better ways to recognize and treat maternal mental health challenges, including peripartum depression.