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Apparent Hack’s law in river deltas
Science, Volume 392, Issue 6797, Page 493-498, April 2026.
Anticipating the future in an algorithmic age
Science, Volume 392, Issue 6797, Page 472-472, April 2026.
Scientist as Subject
Science, Volume 392, Issue 6797, Page 472-472, April 2026.
Disneyland’s factory-inspired future
Science, Volume 392, Issue 6797, Page 471-471, April 2026.
Tiny probes make sense of abnormal bursts in the epileptic brain
“Spikes” hijack neurons involved in cognition—and can be predicted up to 1 second in advance
Deepfakes are everywhere. The godfather of digital forensics is fighting back
Hany Farid, who's spent his career building tools to detect fake images, is facing his biggest challenge yet: AI
AI is starting to beat doctors at making correct diagnoses
Large language model excels at clinical decisions, even in fast pace of a simulated ER
AI helps create bacterium that’s partially missing a universal amino acid
Advance could suggest new ways to synthesize proteins with bespoke functions in medicine and biotechnology
After outcry, European funder reverses abrupt rule change restricting resubmissions
Decision from the European Research Council comes after more than 1000 scientists signed open letter decrying plans
Enigmatic muscle may help explain penguins’ signature waddle
Find also reveals how the birds keep their bodies streamlined when underwater
‘Modern European family’ predates fall of Rome, DNA reveals
Painstaking pedigrees hint at origins and social norms of people living near Rome’s northern frontier
Battle over DNA within fertilized eggs may explain why some IVF procedures fail
Temporarily keeping parents’ genetic contributions separate promotes normal development, mouse study suggests
The role of ultrasound in addressing neurodegenerative diseases: A review of mechanisms, applications, and challenges
With the aging of the global population, neurodegenerative diseases have become a major public health challenge. Currently, there are many limitations in the traditional treatment of neurodegenerative diseases, such as medicine, deep brain stimulation, transcranial magnetic stimulation, and transcranial direct current stimulation, including the inability to penetrate the blood-brain barrier (BBB) accurately and challenges in achieving precise and quantitative control during the treatment...
Serious side effects of Alzheimer's immunotherapy demand scrutiny
Monoclonal antibodies targeting amyloid-β, i.e., lecanemab and donanemab, have recently been approved for treating early Alzheimer's disease (AD). Though these antibodies are by many considered milestones in AD therapy, clinical approvals have been inconsistent due to ongoing debates over their clinical benefit and safety. The reported cognitive decline slowing is modest and often below the thresholds for clinically significant differences on outcome scales. Moreover, these therapies are linked...
Tiny Titans, big promise: Nanotechnology and microRNA in the fight against Alzheimer's disease
Alzheimer's disease (AD) remains the most common neurodegenerative disorder. It is driven by complex molecular dysfunctions that includes amyloid aggregation, tau pathology, and neuroinflammation. It leads to cognitive deficits and memory loss in elderly people. Current treatments offer limited symptomatic relief. Hence, there is urgent need for innovative therapeutics and diagnostic approaches. Among emerging therapeutic targets, microRNAs (miRNAs) have pivotal role in regulating genes linked...
The role of ultrasound in addressing neurodegenerative diseases: A review of mechanisms, applications, and challenges
With the aging of the global population, neurodegenerative diseases have become a major public health challenge. Currently, there are many limitations in the traditional treatment of neurodegenerative diseases, such as medicine, deep brain stimulation, transcranial magnetic stimulation, and transcranial direct current stimulation, including the inability to penetrate the blood-brain barrier (BBB) accurately and challenges in achieving precise and quantitative control during the treatment...
Uridine restores oocyte quality and mitigates female reproductive aging by inhibition of ferroptosis in mice
Advanced maternal age is a key factor in female infertility, primarily due to declines in ovarian reserve and oocyte quality. However, the metabolic mechanisms underlying reproductive aging remain unclear. Here, we show that uridine levels in the plasma and ovaries of aged mice are significantly reduced compared with young controls. Building on this, we find that uridine supplementation significantly improves meiotic maturation, fertilization, and early embryonic development of aged oocytes,...
Aging-associated modulation of UFMylation impairs proteostasis in C. elegans
The attachment of Post-Translational Modifications (PTMs) to proteins regulates their activities and stability. Here we utilized the nematode Caenorhabditis elegans to test whether UFMylation, a PTM which affects key biological functions, regulate aging and protein homeostasis (proteostasis). We find that lowering UFMylation extends lifespan and mitigates the toxicity of aggregation-prone proteins that underlie the development of neurodegenerative disorders in humans. Mass spectrometric analysis...
Multimodal data analysis reveals asynchronous aging dynamics across female reproductive organs
Female reproductive aging has systemic health implications, yet tissue-level dynamics remain poorly understood. Here we integrate deep learning analysis of 1,112 histology images with RNA sequencing from 659 samples across seven female reproductive organs in donors aged 20-70 years. We uncover asynchronous trajectories: the ovary ages gradually, whereas the uterus shows an abrupt molecular and morphological shift around menopause. This uterine transition is independently supported by plasma...
Witnessing Interparental Violence in Childhood and Frailty in Adulthood: Evidence From a National Population-Based Study in China
CONCLUSIONS AND IMPLICATIONS: Witnessing interparental violence in childhood is significantly linked to higher frailty in adulthood. Interventions addressing domestic violence may contribute to healthier aging outcomes.