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Autophagy dysfunction and senescence are established drivers of aging, but their potential interaction remains poorly understood. Here we show that age-related decline of chaperone-mediated autophagy (CMA), a pathway for selective lysosomal protein degradation, changes senescent cell properties and impairs their immune clearance. CMA-deficient cells undergo senescence but acquire proteomic, metabolic and secretory features resembling those in aged senescent cells. Their senescence-associated...

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Pain is the leading cause of disability worldwide, yet no harmonized self-reported reference framework exists to characterize how its burden is distributed across the lifespan and world regions. In this study, we harmonized individual-level self-reported pain data from 6,125,459 participants across 902 population-based data sources in 118 countries to establish global reference trajectories of pain. We implemented these trajectories in an open-access benchmarking platform for positioning...

Proprioceptive deficits are a core feature of Parkinson's disease (PD), but the neural mechanisms by which transcranial direct current stimulation (tDCS) may augment proprioceptive learning remain unknown. This study investigated whether six sessions of anodal tDCS combined with proprioceptive training modulates EEG‑derived aperiodic activity, Lempel‑Ziv complexity (LZC), and theta clustering in individuals with PD. Twenty‑four participants with mild‑to‑moderate PD were randomly assigned to...

CONCLUSIONS AND IMPLICATIONS: Most factors associated with fall-related head impact were nonmodifiable (eg, sex). Training the use of protective fall movements, environmental design (including protective equipment), and education hold promise in reducing the risk of head impact. Future research should prioritize testing modifiable approaches in real-world settings for reducing fall-related head impact and, ultimately, preventing head injuries in the aging population.

Veterans experience mild traumatic brain injury (mTBI) at significantly higher rates than civilians, alongside high rates of comorbid conditions such as PTSD, mood disorders, and alcohol abuse. These conditions have documented impacts on brain health that compound with age. Prior work has demonstrated reduced white matter (WM) integrity and greater age-related trends in WM deterioration in Veterans with mTBI compared to Veterans without mTBI. These studies provide important insights, yet were...

CONCLUSIONS: In this exploratory, partially randomized comparison, TUG-derived dual-task gait cost decreased more in the NMES group, but the marked baseline imbalance limits causal interpretation. DTC appears feasible and potentially responsive as an outcome for future fully randomized sham-controlled rehabilitation trials.

Reduction in brain weight is a hallmark feature of human aging, which is exacerbated in pathologies, such as Alzheimer's disease and other dementias. However, it remains unclear whether a decrease in brain weight with age reflects a vulnerability unique to the human lineage or represents a consequence of an extension of aging processes shared with other primates. To address this question, we examined age-related changes in brain weight across our closest living relatives, the great apes...

Reduction in brain weight is a hallmark feature of human aging, which is exacerbated in pathologies, such as Alzheimer's disease and other dementias. However, it remains unclear whether a decrease in brain weight with age reflects a vulnerability unique to the human lineage or represents a consequence of an extension of aging processes shared with other primates. To address this question, we examined age-related changes in brain weight across our closest living relatives, the great apes...

Cancer immunotherapy can lose its punch when tumor-fighting T cells become exhausted, but researchers may have found a way to keep them going longer. Scientists at Memorial Sloan Kettering Cancer Center identified a signaling molecule called MEK that can push T cells to burn through their energy while producing cancer-killing proteins. In animal and laboratory studies, blocking MEK helped the cells conserve energy, survive longer, and remain active even in the harsh environment around tumors.

Karl Deisseroth, Peter Hegemann, and Georg Nagel honored for developing optogenetics

Scientists have discovered that E-cadherin, a protein best known as the “glue” holding cells and tissues together, has a surprising second job: helping epithelial cells swallow nearby dead cells. Using live zebrafish and mouse embryos, researchers found that cells can dramatically reshape their lower surfaces to engulf cellular debris while keeping their upper surfaces stable, allowing protective barriers to remain sealed.