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As existing drugs falter because of resistance, the world gets a backup—but hard choices loom on how to use it

The group’s latest strategy emphasizes consultation, lacks spending pledges

Filter-feeding flying reptile was likely devoured by a dinosaur during the early Cretaceous

Arachnids build large lookalikes to ward off predators

The development of effective interventions for neurodegenerative disorders, such as posterior cortical atrophy (a visual Alzheimer's variant), remains to be a significant clinical challenge. We introduce a computational framework using convolutional neural networks (CNNs) as in silico models to simulate visual system degeneration and evaluate intervention strategies. By modeling controlled synaptic decay and comparing three distinct retraining approaches, random data (control), accuracy-based,...

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Compared to individuals carrying two copies of the ε4 allele of apolipoprotein E (APOE), ε2 homozygotes have an approximate 99% reduction in late-onset Alzheimer's disease (AD) risk. Here we develop a knock-in model that allows for an inducible 'switch' between risk and protective alleles (APOE4s2). Gene expression and proteomic analyses confirm that APOE4s2 mice synthesize E4 at baseline and E2 after tamoxifen administration. A whole-body allelic switch results in a metabolic profile resembling...

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Tandem light-emitting diodes (LEDs), achieved by vertically stacking multiple units in series to combine the luminance of individual light-emitting elements, are effective for improving efficiency and lifespan compared to single-unit devices^(1-3). In particular, tandem perovskite LEDs benefit from the small Stokes shifts of perovskites⁴, which in principle can enable significant photon recycling between individual perovskite layers and enhance light extraction from trapped modes. However, a...

CONCLUSION: The EcuAging study provides the first evidence on the health of older adults in rural inland Ecuador, highlighting a paradox of preserved physical function alongside impaired mental health. Given that most participants were ≥ 60 years, findings are directly relevant for geriatric populations and underscore the urgent need to strengthen mental health services in rural settings.

CONCLUSION: This longitudinal study suggested that disability and cognition change were bidirectional, with disability showing a stronger impact on future cognitive impairment. Further dynamic investigations and mechanisms between cognitive change and disability are warranted.

Microbiota-derived metabolites have emerged as key regulators of longevity. The metabolic activity of the gut microbiota, influenced by dietary components and ingested chemical compounds, profoundly impacts host fitness. While the benefits of dietary prebiotics are well-known, chemically targeting the gut microbiota to enhance host fitness remains largely unexplored. Here, we report a novel chemical approach to induce a pro-longevity bacterial metabolite in the host gut. We discovered that...