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eIF5A and polyamines restrict mRNA levels in response to ribosome stalls

4 days 1 hour ago
Obstacles to translation elongation stall ribosomes and allow deleterious proteins to accumulate, which threatens cellular health. Cells recognize and clear stalled ribosomes via several interrelated pathways, although the mechanisms by which cells distinguish stalled from normally elongating ribosomes and mount an appropriate response are incompletely understood. While recent work highlights how ribosome collisions help cells to recognize stalled ribosomes, how other factors contribute to...
Chloe M Wohlenberg

Epicenter mapping of cortical morphological dedifferentiation in type 2 diabetes mellitus using morphometric inverse divergence

4 days 1 hour ago
CONCLUSION: The group-level spatial map showed exploratory correspondence with selected normative functional connectivity (FC)- and structural connectivity (SC)-based candidate profiles. Individualized profiles showed greater cross- sectional correspondence with the selected SC-based profile than with the FC-based profile, providing a network-informed description of diabetic brain alterations.
Taipeng Zeng

Muscle-Specific Upregulation of Timeless Mediates Exercise-Induced Amelioration of Age-Related Circadian Rhythm Disruption and Cardiac Dysfunction in Drosophila

4 days 1 hour ago
The core genes of the circadian pathway, such as Timeless(Tim), not only participate in the regulation of biological rhythms, but also play significant roles in DNA damage repair, chronic inflammation, and cellular metabolism. However, it remains unclear whether exercise can delay the age-related phenotypic degeneration by regulating the muscle Tim gene. In here, we first carried out the expression regulation of the muscle Tim gene in the Drosophila by constructing the Mhc-gal4/Tim-UAS system,...
Deng-Tai Wen

Early statin use linked to 15% lower dementia risk

4 days 3 hours ago
Starting statins soon after a type 2 diabetes diagnosis may do more than protect the heart. In a nationwide Danish study of more than 132,000 people, those who began statin treatment within a year of diagnosis had a 15% lower relative risk of developing dementia over 10 years compared with those who did not start statins.