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Leaders of $100 million effort will use automated detection methods and computer models to monitor species’ trends

Landslides, not rituals, may have scattered skulls and bones at Turkey’s famed Göbekli Tepe site

A new experimental drug called CS18 may help break through cancer drug resistance by disabling several of the defenses tumors use to survive treatment. It strengthened existing therapies, restored drug sensitivity in resistant lung cancer cells, and slowed tumor growth in animal models.

Caffeine may make sleep less restorative even when you fall asleep normally and stay in bed for eight hours, with EEG recordings revealing fewer of the slow brain waves associated with deep sleep. Individual sensitivity varies dramatically, meaning even caffeine consumed earlier in the day could affect nighttime recovery for some people.

A minimally invasive procedure called genicular artery embolization could offer a new middle ground between conservative treatments and knee replacement for osteoarthritis. By blocking tiny blood vessels associated with inflammation, GAE can significantly reduce pain, with some patients reporting little or no pain afterward. Studies suggest the benefits may last two to four years in people who respond well.

Incendiamoeba cascadensis may survive in volcanic lakes thanks to a static blanket that shields its proteins from the heat

Menopause is a hallmark process in biological aging that has been implicated in later neurodegenerative risk, but the pathways underlying this connection remain unclear. Here we used blood proteomics data from several cohorts to identify biological changes associated with menopause and its links to brain aging. In n = 80 rigorously staged (STRAW+10) pre-, peri- and postmenopausal women (aged 43-58 years) with serum NULISAseq proteomics, we show that spontaneous menopause is characterized by...

Skeletal ageing involves changes in endocrine regulation, mechanical loading and cellular function that can impair bone remodelling. Cellular senescence and the senescence-associated secretory phenotype (SASP) have emerged as mechanisms that help close this gap. In the ageing bone microenvironment, senescent osteocytes, mesenchymal stem cells, osteoblasts, immune cells, and vascular endothelial cells secrete pro-inflammatory cytokines, chemokines, matrix metalloproteinases, and Wnt antagonists...

Menopause is a hallmark process in biological aging that has been implicated in later neurodegenerative risk, but the pathways underlying this connection remain unclear. Here we used blood proteomics data from several cohorts to identify biological changes associated with menopause and its links to brain aging. In n = 80 rigorously staged (STRAW+10) pre-, peri- and postmenopausal women (aged 43-58 years) with serum NULISAseq proteomics, we show that spontaneous menopause is characterized by...

Aging clocks are typically trained on pooled multi-tissue data, implicitly assuming that aging is uniform across organs. Here we challenge this assumption by constructing 49 transcriptomic clocks across 47 tissue types and 2 cell-line categories from GTEx v8 (948 unique donors contributing to the retained clock categories) using donor-grouped cross-validation. Clocks achieved a median Pearson r of 0.543 (best: artery aorta, r = 0.855). We identified 10,253 unique clock genes, of which 69.2%...

While osteoarthritis (OA) has traditionally been viewed as a localized joint disorder, systemic metabolic dysfunction is increasingly recognized as a key contributor to its pathogenesis. Here, we identify a liver-cartilage micronutrient axis in which hepatic dysfunction promotes OA through impaired selenium (Se) metabolism. Nationwide cohorts reveal elevated OA prevalence among individuals with liver disease. In murine models of acute and chronic liver injury and metabolic dysfunction-associated...

Immunosenescence-the age-associated remodeling of the immune system-has emerged as a potential modifier of chronic inflammatory disease. This review examines the evidence that immunosenescence may contribute to the chronicity, refractoriness, and therapeutic heterogeneity of uveitis, and considers the clinical and translational implications of this framework. It first outlines the features of immune aging, including thymic involution, contraction of the naïve T cell pool, accumulation of memory...

CONCLUSION: A significant correlation between fatigue (MF and SPF) and inflammation was found. Among the inflammatory biomarkers investigated, IL-6 showed the most consistent association with both MF and SPF across the included studies.

Intracerebral hemorrhage (ICH), caused by the rupture of blood vessels within the brain parenchyma, represents the most severe form of stroke, characterized by the highest mortality rate and predominantly affecting the elderly population. Glial cells, including microglia, astrocytes, and oligodendrocytes, serve as the resident immune cells of the central nervous system and undergo significant metabolic reprogramming following ICH. Microglia exhibit dual roles in post-ICH tissue damage by...

CONCLUSION: Sensory impairment, particularly dual sensory impairment, was most consistently associated with early cognitive deterioration and reduced cognitive recovery. It was not consistently associated with higher dementia progression or mortality transition rates. Death-inclusive multistate modeling may help identify where potentially modifiable sensory impairment is related to cognitive ageing trajectories.

INTRODUCTION: Despite growing interest in age-related cortical mechanisms of postural control, heterogeneity across studies has limited the synthesis of existing evidence. This systematic review aimed to (1) characterize age-related alterations in cortical activity during standing balance tasks with sensory, cognitive, and mechanical challenges; (2) examine the association between cortical activity and postural sway; and (3) characterize the current methodology of assessing cortical activity...

Aging is associated with declining protective immunity and increased autoreactivity, yet the mechanisms linking these processes remain incompletely understood. B lymphocytes are central to this paradox because they integrate antigen recognition, innate signaling, and differentiation under tightly regulated tolerance checkpoints. This review advances the hypothesis that aging appears to drive a progressive, B cell-intrinsic relaxation of central and peripheral tolerance, leading to the...