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Solution processing remains the dominant route to high-performance perovskite/silicon tandems, but it remains challenging to simultaneously achieve industrial scalability and long-term reliability^(1-3). Thermal evaporation is more industrially viable, yet it has not been successfully demonstrated for large-area perovskite/silicon tandems, largely due to the thermal degradation of formamidinium iodide (FAI) during high-temperature evaporation. Here we synthesize a formamidinium-based eutectic...

Pharmacological glucagon-like peptide-1 receptor (GLP-1R) activation reduces food intake and is an effective therapy for type 2 diabetes and obesity¹. The use of GLP-1 medicines has revealed pleiotropic beneficial effects beyond glucose and weight control^(2-5), but little is known about the underlying basis of the pleiotropic effects. Here, treatment of 20-month-old female C57BL/6 mice with the GLP-1R agonist semaglutide for 3 months improved physiological function, attenuated hallmarks of...

Chemotherapy-induced bone loss represents a major clinical challenge, particularly in aging populations, yet the contribution of cellular senescence to this process and its therapeutic potential remain incompletely understood. Here, we investigated the role of chemotherapy-induced cellular senescence in mediating skeletal deterioration following chemotherapy and evaluated the therapeutic potential of senolytic treatment. Young (3-month-old) and aged (20-month-old) male and female mice were...

Excessive alcohol consumption accelerates cardiovascular aging by promoting oxidative stress, inflammation, lipid dysregulation, fibrotic remodeling, and loss of ventricular-vascular reserve. PCSK9, a key regulator of cholesterol metabolism, has emerged as a mediator of age-related cardiovascular dysfunction and alcohol-associated liver and neurovascular injury. We investigated whether PCSK9 inhibition protects against alcohol-induced cardiovascular dysfunction and associated cardiac-hepatic...

Global life expectancy has risen since 1973 from 58 to over 73 years, while the share of people aged 65 years and older has doubled to 10% and is projected to reach 21% by 2073. This shift is linked to an epidemiological transition from infectious to chronic disease. Here, using Global Burden of Disease data, we reframe this transition by statistically grouping diseases on the basis of their impact over the life cycle, yielding four clusters: infant, early-adult, later-adult and aging-related....

Mutations and polymorphisms in the Rho guanine nucleotide exchange factor 10 (ARHGEF10) locus are associated with behavioral and locomotor dysfunctions in humans, including psychiatric disorders and polyneuropathies that show age- and sex-specific prevalence. ARHGEF10 encodes a conserved guanine exchange factor that activates Rho GTPases and has proposed roles in cell migration and adhesion, but the relevant cell types and mechanisms underlying its age- and sex-dependent effects remain unclear....

Science, Ahead of Print.

Some of the attention patterns that make ADHD challenging may also help spark creativity by allowing the brain to explore more ideas and unexpected connections. Researchers think creative activities could potentially channel this “defocused attention” while helping strengthen the brain systems involved in focus and self-control.

Sitting for long, uninterrupted stretches may carry greater health risks than sitting the same amount of time in shorter bouts. Researchers found that each extra hour of prolonged sedentary behavior was associated with a 9% higher risk of cancer death. Breaking up sitting with movement showed the opposite pattern, while replacing an hour of prolonged sitting with light activity was linked to a 12% lower risk.

Regulators crack down on stories that were too positive about drugs that target GLP-1

Research in mice finds that psilocybin protects against nerve damage and sensitivity caused by common cancer drugs

Amid a shortage of human reviewers, tests indicate AI can assist—but is not a savior

New approach that induces patients to make their own CAR-T cells could be faster and cheaper than existing methods