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Mitochondria play central roles in cellular metabolism and in key processes such as inflammation, stress response, cell death and signalling. Mitochondrial quality control (MQC) mechanisms continuously monitor organelle integrity and function, and repair or eliminate damaged mitochondria to replace them with newly formed, healthy organelles. MQC is particularly important under metabolic or environmental stress conditions. Failure of MQC paves the way to chronic diseases, such as diabetes,...

CONCLUSION: This study offers an empirically grounded, contextually situated understanding of well-being among older adults in an urban Indonesian setting, extending existing frameworks by foregrounding lived experience and relational interdependence.

CONCLUSIONS: Respondents demonstrated positive attitudes towards their own ageing in the domains of physical change and psychological growth, whereas more negative attitudes were observed in the psychosocial loss domain. Loneliness and depressive symptoms were significantly associated with a more negative self-perception of ageing among older adults. A more negative self-perception of ageing was also more frequently observed among respondents with a poorly developed social network, poorer...

CONCLUSION: Adults aged 65 and above in this study demonstrated a moderate level of resilience and lower well-being scores. Higher resilience scores were significantly correlated with increased subjective well-being. These results suggest that resilience acts as a vital internal resource that relates to mental health outcomes in the aging population, highlighting the potential for interventions focused on enhancing psychological strengths.

CONCLUSIONS: IAS is a biologically informed, geriatric-oriented index of IMV that integrates aging-related immune remodeling with dynamic inflammatory responses in older adults with AECOPD. Rather than serving as a definitive measure of fixed immune-aging burden or as a dedicated infection classification tool, IAS provides a quantitative framework for biologically relevant immune-inflammatory vulnerability stratification and short-term prognostic assessment. Further prospective multicenter...

Wildfire smoke poses a growing global health risk, largely from fine particulate matter (PM(2.5)) emissions. Prescribed fires, which are critical for maintaining resilient forests in many locations, can also reduce wildfire emissions in treated areas that later burn. However, prescribed fires also produce smoke, creating a tradeoff in their net impact on PM(2.5) emissions. We develop a mathematical framework showing that, under most current conditions globally, prescribed fire emissions are...

INTRODUCTION: MicroRNAs (miRNAs) are promising biomarkers for the diagnosis and prognosis of neurodegenerative diseases. Over the past few years, miR-34a-5p and miR-126-3p have become some of the most characterized miRNA, the former being associated with cellular senescence and apoptosis and the latter with the maintenance of vascular endothelial function. The present study aimed to evaluate diagnostic performance of miR-34a-5p and miR-126-3p for cognitive dysfunction in CSVD patients. In...

Mild cognitive impairment (MCI) is associated with age-related alterations in neural oscillatory activity and cerebral hemodynamics, while mobility limitations often restrict participation in conventional exercise-based interventions. This study investigated exploratory, single-arm, within-subject short-term neurovascular and electrophysiological responses to a combined visual and vibration stimulation protocol in older adults with MCI. Cerebral blood flow was assessed using near-infrared...

Chronic pain affects more than half of older adults and has been increasingly linked to cognitive decline, a relationship with profound implications for healthy aging. Ramezani and colleagues examined this association in 1,343 Iranian older adults from the Birjand Longitudinal Aging Study, a well‑characterised cohort from an understudied population. The study has notable strengths: a large sample size, population‑based recruitment, and DAG‑guided covariate selection. However, three...

CONCLUSIONS: Structural and functional muscle indicators showed divergent age-related patterns among rural community-dwelling women. The performance-based 5×STS demonstrated substantially greater relative differences than structural indicators, supporting the inclusion of functional assessments alongside structural measures for age-stratified evaluation in rural settings.

Fish oil supplements successfully delivered omega-3s to the brain, but a two-year study found no meaningful benefits for memory, cognition, or Alzheimer’s-related brain changes. The results challenge the idea that fish oil pills can help prevent Alzheimer’s and shift attention toward overall diet and lifestyle instead.