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The autophagy-inhibitory tissue hormone DBI/ACBP contributes to the pathogenesis of multiple organ dysfunction syndrome in septic shock
Systemic microbial infection leading to septic shock with multiple organ dysfunction syndrome (MODS) is a major cause of mortality and represents a substantial unmet medical need. We recently observed that, compared with uninfected controls, patients with septic shock exhibit significantly elevated circulating concentrations of the tissue hormone acyl-CoA binding protein (ACBP), encoded by the diazepam binding inhibitor (DBI) gene, a potent inhibitor of autophagy. Increased plasma DBI/ACBP...
Radical proposal would block solar storms with orbital ‘airbag’
Gases released from satellites could slash the threat of severe space weather
Your brain starts making social decisions before you do
Researchers found that social behavior begins in the brain before it becomes visible as movement. In zebrafish, a coordinated pattern of activity spread across the brain several seconds before the animals approached another fish. A higher brain region called the pallium played a key role, and fish with stronger neural signals were generally more social.
Exclusive: NSF watchdog unit is no longer investigating research misconduct
New policy hands universities the reins in probing allegations against faculty