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Author Correction: Pulsed electromagnetic fields mediate sensory nerve regulation for bone formation in aging models
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Nanotherapy targets senescent cells
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Author Correction: Sex-specific biological aging clocks across organs and omics
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Serum neurofilament light protein as a biomarker across the cognitive decline continuum: a cross-sectional study from an Indian cohort
CONCLUSIONS: Serum NfL demonstrated potential as a sensitive and non-invasive biomarker for early detection and staging of cognitive decline. The establishment of population-specific cut-offs within an Indian cohort contributes to global efforts toward standardizing blood-based biomarkers for AD.
Can science make your dog live longer? Longevity craze comes to pets
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How well do dementia risk scores predict dementia? A systematic review and meta-analysis
In our systematic review and meta-analysis, we aimed to assess the predictive accuracy and clinical applicability of ten dementia risk assessment scores for incident dementia in cohort studies. Three of 10 risk scores had sufficient, comparable data for a meta-analysis. We analyzed the Cardiovascular Risk Factors Ageing and Dementia (CAIDE), Lifestyle for brain health (LIBRA), and Alzheimer's Disease Risk Index (ANU-ADRI) in middle- and older-aged baseline populations with short, medium, and...
Aerobic exercise training alters gastrointestinal microbiota and enhances exercise capacity in UM-HET3 mice
Aerobic exercise attenuates age-related physiological decline, potentially through favorable modulation of gut microbiota diversity. The purpose of this study was to characterize aerobic exercise training (ET)-induced alterations in the gut microbiome of aging, genetically heterogeneous UM-HET3 mice and examine associations between microbial shifts and changes in body composition (body weight, lean mass, and fat mass) and exercise capacity (total work, distance, and duration). Male UM-HET3 mice...
Valuing a Quality-Adjusted Life Year (QALY): willingness to pay among older adults in Iran
CONCLUSIONS: These findings provide a valuable reference for cost-effectiveness studies on interventions for older adults, enabling policymakers to assess the economic viability of allocating healthcare resources to this population. Furthermore, policymakers can consider the reasons behind older adults' reluctance to invest in longer, healthier lives, which could inform targeted strategies to encourage greater investment in their health.
Proteomic ageing clocks: methods, mechanisms and the muscle connection
Proteomic ageing clocks are emerging tools that estimate biological age from protein abundance patterns. Most models are developed using blood capturing inflammatory, metabolic, and extracellular proteins, including secreted signalling factors. Large-scale plasma studies now predict chronological age, disease risk and mortality, but muscle-related models remain indirect, relying on organ-enriched circulating proteins rather than biopsy-derived skeletal muscle clocks. We review current proteomic...