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Pregnancy and aging are associated with stress on the body and show multi-system physiological changes. We asked whether we can learn about aging from the changes in pregnancy. To do so, we analyzed weekly cross-sectional data on 70 lab tests from 300,000 pregnancies and 1.4 million non-pregnant females aged 20-89. Using a biological age model trained on non-pregnant females, we observed that pregnant females' apparent age dropped by 5 years in the first trimester, rose by 20 years toward...

Reducing CO(2) emissions throughout a product's life cycle, mainly encompassing four stages of raw materials extraction, processing, service, and end of life, is essential for carbon neutrality. Passive daytime radiative cooling coatings offer CO(2) reduction benefits, but primarily only during service stage. Life cycle assessment demonstrates maximized full life-cycle CO(2) reduction requires innovations in both raw materials extraction and service periods. Here, we develop a full life‑cycle...

CONCLUSION: The findings indicate that active engagement in social activities, encompassing community, cognitive, home-based creative, and physical activities, is associated with slower EAA, marked by several clocks in older adults, providing evidence for the benefit of social activities for health and offering valuable insights for promoting "Active Aging" initiatives.

CONCLUSION: The global number of people living with dementia nearly tripled from 1990 to 2021, mainly due to increases in population ageing and growth. The findings emphasize the need for comprehensive strategies to address ADOD, including prevention, early diagnosis, and effective management, with a focus on gender and regional disparities.

[This corrects the article DOI: 10.3389/fnagi.2025.1613566.].

CONCLUSION: The global ADOD burden is escalating with pronounced dynamic heterogeneity in growth velocity and distinct spatial patterns. Our multi-model projections warn of a mounting crisis, disproportionately impacting women, the oldest-old, and rapidly aging middle-income regions. Public health strategies must evolve from static assessments to dynamic surveillance and geographically tailored interventions, with urgent investment in prevention and care systems in high-growth clusters.

Inoculating soil with pink microbes could help reduce the use of toxic insecticides.

Idebenone (IDE), an analog of ubiquinone, has demonstrated therapeutic potential across various neurodegenerative disorders. Clinically, IDE has been shown to exert neuroprotective effects in Parkinson's disease (PD), being capable of alleviating motor symptoms as well as reducing depressive and anxious moods. However, the mechanism of action of IDE in PD has not been fully elucidated. Thus, the present study aims to investigate the potential effects of IDE on...

Aging is the primary cause of cognitive decline. Despite extensive study, the molecular mechanisms driving aging-associated cognitive decline remain unclear. Here, we describe a proteostasis-independent function of SEC61A1 and its involvement in aging-associated cognitive decline. SEC61A1 regulates ER-mitochondria contact sites, affecting mitochondrial DNA and RNA synthesis and subsequently leading to changes in innate immune signaling mediated by mitochondrial double-stranded RNA (mt-dsRNA)....

Long-term care is today one of the most pressing issues in public policy. Its relevance is increasing everywhere but mostly, due to population aging, in low- and middle-income countries. Despite the advances in the past decades regarding the implementation of long-term care systems in several countries, the COVID-19 pandemic showed their fragility and called to rethink long-term care around the world. Issues like quality, workforce shortages, and financial sustainability are key in countries...