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Improving access to essential medicines via decision-aware machine learning
Digital quantum magnetism on a trapped-ion quantum computer
Safety and efficacy of intratumoural anti-CTLA4 with intravenous anti-PD1
Recycling of spin-triplet excitons in organic photovoltaics
Decarboxylative alkylation of alkenes
Immunity gets a boost from a surprising place — breakfast
Reply to: Overestimating outsourced biodiversity loss may misguide policy
Overestimating outsourced biodiversity loss may misguide policy
Author Correction: Broadly stable atmospheric CO<sub>2</sub> and CH<sub>4</sub> levels over the past 3 million years
To misinformation researchers, AI is a scourge—and a powerful new tool
Surge in generative AI is upending a field that was just finding its feet
A novel gene-therapy approach to ‘functionally cure’ HIV succeeds in some monkeys
Six animals suppressed AIDS virus after one shot of treatment that makes cell-receptor antibody
House spending panel bumps up Trump’s request for NSF and NASA
Draft bill is an early sign that Congress again thinks Trump has gone too far in cutting research
As foot-and-mouth disease explodes in South Africa, experts warn of threats in other countries
A viral strain originating in wild buffalo in Kruger National Park is spreading rapidly in cattle
Associations of social isolation and loneliness with neurological disorders, psychiatric disorders, brain structures and behavioural phenotypes among UK Biobank participants
Social isolation and loneliness are increasingly recognized as detrimental risk factors for brain health. Here, utilizing data from 383,421 participants in the UK Biobank, we identify significant associations between social isolation, loneliness, and the incidence of 11 neurological and psychiatric disorders, including major depressive disorder (MDD), schizophrenia, bipolar disorder, anxiety disorders, sleep disorders, dementia, Alzheimer's disease, Parkinson's disease, stroke, multiple...
Neighborhood Racial Composition, Socioeconomic Status, and Obesity Among Older Black Adults
ObjectivesObesity is common among older Black adults, but its underlying drivers, such as neighborhood racial composition (NRC), remain understudied. This study examined the association between NRC and obesity among older Black adults, evaluating the role of individual-level socioeconomic status (SES).MethodsData from the Nashville Stress and Health Study was linked to five-year estimates from the American Community Survey. Obesity was defined as body mass index ≥30 kg/m². NRC was measured with...
Face aging rate quantifies change in biological age to predict cancer outcomes
Chronological age predicts cancer survival but does not capture differences in biological aging rates. We apply FaceAge, an artificial intelligence algorithm that predicts biological age from a facial photograph, to serial clinical facial photographs to calculate the Face Aging Rate (FAR; change in FaceAge divided by the time between photographs). We analyze data from 2276 cancer patients receiving radiation therapy, using photographs captured during routine care. Higher FAR is associated with...
SIRT7 links H3K36ac epigenetic regulation with genome maintenance in the mouse testis
Reproductive aging is an increasing health concern that affects family planning and overall well-being. While extensively studied in females, the mechanisms driving male reproductive aging remain largely unexamined. Here, we found that mammalian Sirtuin 7 sustains spermatogenesis in an age-dependent manner. Sirtuin 7 deficiency in mice increases histone H3 lysine 36 acetylation in spermatogonia and spermatocytes, a pattern also observed during natural aging, and leads to altered chromatin...
Author Correction: A complex secretory program orchestrated by the inflammasome controls paracrine senescence
No abstract
Greater recalled pain and movement-evoked pain are associated with longer 400-m walk and repeat stair climb timein older adults: the study of muscle, mobility, and aging
Musculoskeletal pain and mobility disability are common in older adults, but relationships among pain parameters and physical performance are poorly understood. We quantified the impact of different pain measures-recalled and movement-evoked pain-on walk and stair climb time in older adults from the Study of Muscle, Mobility and Aging (SOMMA). In SOMMA (N = 879, age = 76.3 ± 5.0 years, 59% women, 84% non-Hispanic White), participants completed usual pace 400-m walk (avg = 6.6 ± 1.2 min) and...
Pleiotropy and disease interactors: the dual nature of genes linking ageing and ageing-related diseases
Ageing-related diseases (ARDs) display diverse phenotypes yet share an age-dependent rise in incidence, suggesting mechanistic links with ageing processes. We examined whether ageing-related genes differ systematically from genes associated with multiple ARD clusters. Across 57 ARDs from UK Biobank, network analyses showed that ageing-related genes, although rarely ARD-associated, lie significantly closer to many ARDs through greater-than-chance proximity in protein-protein interaction (PPI) and...