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Blood-based biomarkers for Alzheimer's disease: Advances in early detection and monitoring of age-related neurodegeneration

3 days 21 hours ago
Alzheimer's disease (AD) presents a critical global challenge, accounting for over 60 % of the 57 million current dementia cases worldwide, with prevalence projected to exceed 100 million by 2050. Traditional diagnostic approaches, such as cerebrospinal fluid (CSF) analysis and neuroimaging are constrained by invasiveness, high costs, and limited accessibility, particularly problematic in aging population where early detection is crucial for effective intervention. This review synthesizes recent...
Wenting Fu

Should all MCI with Alzheimer's biological diagnosis receive anti-amyloid therapy?

3 days 21 hours ago
Our perspective addresses one of the most pressing and timely debates in contemporary neurology and health policy: whether the recent approval of anti-amyloid monoclonal antibodies for Alzheimer's disease should extend to all individuals with mild cognitive impairment (MCI; a large population of tens of millions of individuals worldwide mainly represented in Countries with aged population) who test positive for amyloid biomarkers, despite wide variability in prognosis and therapeutic response...
Paolo Maria Rossini

Mitochondrial DNA drives NLRP3-IL-1beta axis activation in microglia by binding to NLRP3, leading to neurodegeneration in Parkinson's disease models

3 days 21 hours ago
Dysregulated mitochondrial DNA (mtDNA) promotes inflammatory response and disease progression. However, the mechanism and role of mtDNA-mediated inflammatory activation in the pathogenesis of Parkinson's disease (PD) are not yet clear. This study demonstrates that the injection of mtDNA into the substantia nigra pars compacta induces PD pathology in mice, characterized by the loss of dopaminergic (DA) neurons and the activation of microglia. Transcriptomic profiling of magnetic-activated cell...
Qinglin Gan

Impaired BDNF-TrkB trafficking and signalling in Down syndrome basal forebrain neurons

3 days 21 hours ago
Brain derived neurotrophic factor (BDNF) and its receptor tropomyosin-related kinase B (TrkB) play crucial roles in neuronal development, synaptic transmission, and neuroplasticity. Deficits in BDNF/TrkB signalling and trafficking have been identified in several neurodegenerative diseases, including Alzheimer's disease (AD). Individuals with Down syndrome (DS) are at an increased risk of developing AD compared to the general population. Basal forebrain neurons (BFNs) are among the first to...
Emily Blackburn

Bridging global diversity gaps in Parkinson disease research

3 days 21 hours ago
The global burden of Parkinson disease (PD) is rapidly shifting towards low-income and middle-income countries (LMICs), which already account for 44% of all individuals with PD. Despite this trend, the populations of LMICs and other under-represented populations defined by ethnicity, sex, geography and minority groups within high-income countries remain largely excluded from PD research. The continuation of these disparities limits our knowledge of disease biology and restricts the applicability...
Daniel Teixeira-Dos-Santos

ICE: robust detection of cellular senescence from weak single-cell signatures using imputation-based marker refinement

3 days 21 hours ago
Detecting senescent cells from single-cell RNA-seq data remains challenging due to the weak and non-specific expression of canonical markers. Here, we demonstrate that simple expansion of these low-signal marker sets does not improve detection accuracy. To address this limitation, we develop ICE (Imputation-based Cell Enrichment), a computational framework that integrates expression imputation with marker refinement. ICE improves the detection of senescent cells in pancreatic β cells and...
Peng Xu

Comparative effects of EXG and conventional therapies on muscle strength and balance in older people: A meta-analysis and meta-regression

3 days 21 hours ago
This systematic review with meta-analysis aimed to analyze the effects of exergaming (EXG) versus conventional therapies on muscle strength, balance, and fear of falling in healthy older people. A systematic literature search was conducted in six generic databases (PubMed, Medline, CINAHL Complete, Scopus, Cochrane Library, and Web of Science) with no start date restrictions until May 2025. The PRISMA, TESTEX, Rob 2 and GRADE tools were used to assess the methodological quality and certainty of...
Jordan Hernandez-Martinez

Blood-based biomarkers for Alzheimer's disease: Advances in early detection and monitoring of age-related neurodegeneration

3 days 21 hours ago
Alzheimer's disease (AD) presents a critical global challenge, accounting for over 60 % of the 57 million current dementia cases worldwide, with prevalence projected to exceed 100 million by 2050. Traditional diagnostic approaches, such as cerebrospinal fluid (CSF) analysis and neuroimaging are constrained by invasiveness, high costs, and limited accessibility, particularly problematic in aging population where early detection is crucial for effective intervention. This review synthesizes recent...
Wenting Fu