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Twenty-year persistence of SARS-CoV-1 immune imprinting shapes antibody responses to SARS-CoV-2 infection
Antibody imprinting is well recognized, yet its long-term dynamics and epitope specificity remain poorly understood. Here, we studied individuals sequentially infected with SARS-CoV-1 (SARS-1) and SARS-CoV-2 (SARS-2) over two decades and found durable imprinting of antibody responses following SARS-2 BF.7 breakthrough infection. Approximately 60% of isolated monoclonal antibodies were SARS-1 imprinted and targeted conserved receptor-binding domain regions, whereas 37% overcame imprinting to...
Athero-Oncology: Vascular Smooth Muscle Cell Tumor-Like Transformation in Atherosclerosis and Therapeutic Opportunities
Atherosclerosis (AS) is the main pathological basis of cardiovascular diseases, and its pathogenesis and treatment strategies remain major challenges. Recent advances in single-cell RNA sequencing and lineage tracing have revealed that vascular smooth muscle cells (VSMCs) are not merely passive structural components of atherosclerotic plaques, but highly plastic participants that undergo clonal expansion, phenotypic modulation, and transdifferentiation into functionally diverse cell states....
From self-quantification to predictive ageing: Digital twins as a framework for healthy ageing and longevity
Recent advances in biomarker profiling, wearable sensing, and high-density longitudinal self-monitoring have generated detailed individual-level datasets demonstrating that many ageing-associated measures, including cardiometabolic markers, inflammatory signals, functional performance metrics, and epigenetic age estimates remain highly modifiable in adulthood. However, these data also reveal substantial heterogeneity in response timescales and durability, with rapid reversibility of many...
Stomach cancer burden among older adults in aged and super-aged societies, 1990-2023: a global analysis: A short informative title: Elderly Stomach Cancer Burden in Aged and Super-Aged Countries, 1990-2023
CONCLUSIONS: Stomach cancer mortality rates declined substantially among adults aged 65 years or older, but absolute deaths declined less because demographic growth and ageing offset epidemiological gains, with burden increasingly concentrated at the oldest ages. Progress should therefore be assessed using both age-standardised rates and absolute burden.
DHCR24 regulates endothelial senescence through the SPHK2/SPNS2-S1P axis
Vascular endothelial senescence is a pivotal driver of age-related pathologies. Metabolism plays a critical regulatory role in endothelial cell senescence. Our previous studies have shown that deficiency of DHCR24, a gene involved in lipid metabolism, promotes endothelial cell senescence. However, how DHCR24 participates in endothelial cell senescence through lipid metabolism remains unclear. Using endothelial-specific DHCR24 knockout mice and replicative senescent human umbilical vein...
Preserved cerebellar functions despite structural degeneration in older adults
Aging is frequently perceived negatively due to its association with declines in brain and motor function yet not all aspects of brain function are equally affected. The cerebellum, a brain region closely linked to motor control, undergoes clear structural changes with age, but the impact of this degeneration on cerebellar function remains debated. The present study thoroughly investigates the impact of age on cerebellar function by measuring cerebellar motor and cognitive performance across the...
This comic book artist is drawing women into prehistory
Science chats with illustrator Ulli Lust, whose work is countering ice age gender myths
Scientists say love follows hidden mathematical rules
Could math help explain why some relationships survive life’s inevitable stresses while others slowly fall apart? Researchers have spent decades developing mathematical models that treat romantic feelings as changing systems, revealing patterns in attraction, emotional reactions, conflict, and recovery.
Cialis linked to higher glaucoma risk in large study
A large study of nearly 74,000 men suggests that long-term use of tadalafil, best known as Cialis, may be linked to a higher risk of glaucoma and other eye pressure problems. Men prescribed the drug for urinary symptoms caused by an enlarged prostate were 22% more likely to develop glaucoma, 32% more likely to develop ocular hypertension, and 33% more likely to be diagnosed with primary open-angle glaucoma or start glaucoma treatment over five years.
Daily briefing: Bunsen burners don’t waft bacteria away from workbenches
Author Correction: Destabilizing heterochromatin by APOE mediates senescence
Anthropic AI ‘formalizes’ proof of Fermat’s last theorem — a milestone for mathematics
Aging rises, yet the double burden of illness remains
Isaac Newton’s remarkable year — and the plagiarism accusations that followed
The secret life of a cell-cycle gatekeeper of breast cancer
Probing the proteome at cellular scale
Author Correction: A mouse brain stereotaxic topographic atlas with isotropic 1-μm resolution
Author Correction: AhR inhibition promotes axon regeneration via a stress–growth switch
Your gut microbiome may be more contagious than scientists thought
Scientists have found evidence that some gut bacterial populations can spread rapidly between people and across continents, suggesting the microbiome may be more transmissible than previously thought. The research also revealed hidden bacterial groups associated with aging, colorectal cancer, inflammatory bowel disease, and type 2 diabetes.
Cancer cases could surge 67% worldwide by 2050
Cancer is becoming an even larger global health threat, with nearly 21 million people diagnosed and 9.8 million dying from the disease in 2024. New estimates suggest about 1 in 5 people worldwide will develop cancer during their lifetime, while cases could climb by 67% to 34 million by 2050 simply because populations are growing and aging.