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Interplay between cohesin and TORC1 links chromosome segregation and gene expression to environmental changes
Cohesin is a DNA tethering complex essential for chromosome structure and function. In fission yeast, defects in the cohesin loader Mis4 result in chromosome segregation defects and dysregulated expression of genes near chromosome ends. A genetic screen for suppressors of the thermosensitive growth defect of mis4-G1487D identified several hypomorphic mutants of the Target of Rapamycin Complex 1 (TORC1), a conserved kinase that integrates cellular signals to regulate growth and metabolism through...
Earliest signs of vision recorded in ancient sea-floor tracks
Daily briefing: What it will take to stop the spiralling Ebola outbreak
Landmark cancer trial shows success against ‘undruggable’ cancer — raising hopes for future treatments
Feynman solved the ‘restaurant dilemma’ 50 years ago — now a study confirms his mathematics
Smartphone camera takes users’ pulse passively during device use
Passive heart-rate monitoring during smartphone use in everyday life
Enantioselective hydrogen atom relay via non-covalent catalyst assembly
Obesity doesn’t equate to ill health: why the ‘disease’ label doesn’t always fit
Poor supervision is pushing young researchers out of academia
Robust projections of risks to the Amazon rainforest
Why it’s time to bin recommendation letters in science job applications
Science fiction: nine lab-life novels for your holiday reading
How long can humans live? We simply don’t know
Polymarket vs science: why researchers are sceptical of the prediction-market hype
Desperate to fight Ebola outbreak, Congo weighs using longshot vaccine options
Existing vaccines may offer some protection against the rare strain now circulating—but the evidence is scant
Court blocks NSF’s transfer of climate lab’s supercomputing facility
Proposed switch in management caused irreparable harm to NCAR, judge finds
Exclusive: HHS is now weighing in on science in NIH grants
Staffers say comments coming after NIH’s own approvals are overriding peer review
Scientists found the hidden switch fueling alzheimer’s brain inflammation
Scientists at Scripps Research have uncovered a molecular “switch” that appears to fuel the damaging brain inflammation seen in Alzheimer’s disease. They found that a protein called STING becomes chemically altered in a way that keeps the brain’s immune system stuck in overdrive, harming the connections between nerve cells.
Why cancer spreads more in middle age than in old age
Melanoma may not become steadily more dangerous with age as scientists once assumed. In a surprising discovery, researchers found that cancer spread was lowest in young mice, surged in middle-aged mice, and then dropped again in very old mice. The key appears to be a special type of immune cell that helps keep cancer dormant and prevents it from spreading.