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Let’s talk about biomedical research kits
World-first: therapy to make cells young again trialled in a person
A treasure trove of Neolithic necklace beads
A unicellular relative links aggregative multicellularity to animal origins
Author Correction: PTC-bearing mRNA elicits a genetic compensation response via Upf3a and COMPASS components
The best way to start your day? The science backs naked cartwheels in the sun
Preventing cancer requires more than a list of carcinogens
Science must be seen as a viable profession for the many, not the few
Arson attacks at Ebola hospitals are a cry for regional development
AI technology must serve human cognitive development, not the other way around
Author Correction: A broadly protective antibody targeting gammaherpesvirus gB
The secret reason some cancer treatments stop working
Scientists have uncovered a hidden immune system "brake" that may help cancers avoid being destroyed. The molecule, called SLAMF6, weakens the body's cancer-fighting T cells and can leave them exhausted over time. Researchers developed antibodies that block this brake, allowing immune cells to stay stronger and attack tumors more effectively in mice.
World's largest opioid review finds they often don't work
The largest review ever conducted on opioids for acute pain found that these widely prescribed drugs often deliver only small, short-lived benefits. For many common conditions, including some surgeries and kidney stone pain, opioids performed no better than a placebo. Researchers also found higher rates of side effects and warned that dependence can begin after only a short period of use.
‘Working without them is painful’: WHO’s Ebola chief reflects on U.S. colleagues’ absence
Chikwe Ihekweazu, on the ground in Congo, discusses challenges of bringing the outbreak under control
Misconduct sleuth in China swiftly gains acclaim for calling out questionable papers
Independent vlogger Geng Hongwei galvanizes often-sluggish institutions to investigate and punish prominent scientists
Canadian biologists decry plans to bypass environmental reviews for infrastructure projects
Government proposal to speed up development could harm protected plants and animals, scientists say
NSF imposes stricter conflict-of-interest rules for grant-review panels
Researchers say changes could further burden the understaffed agency
Scientists found a new Alzheimer’s trigger and a drug that stops it
Researchers have identified a new Alzheimer’s target and created an experimental compound that blocks a damaging process inside brain cells. In mice, the treatment slowed nerve cell loss, reduced Alzheimer’s-related changes, and even appeared to promote healthier aging.
Scientists discover the brain chemical that helps you break bad habits
Scientists have uncovered a key brain signal that helps us break old habits and adapt when circumstances suddenly change. By watching mice navigate a virtual maze, researchers found that disappointment—when an expected reward failed to appear—triggered a surge of the neurotransmitter acetylcholine, making the animals more likely to try a new strategy. When acetylcholine was blocked, the mice became less flexible and were more likely to stick with outdated choices.
Ultrastructural diversity and subcellular organization of nigral Lewy pathology in Parkinson's disease
Lewy bodies, the defining pathological feature of Parkinson's disease, are intraneuronal inclusions enriched in aggregated alpha-synuclein (αSyn). We used correlative light and electron microscopy to selectively investigate phosphorylated αSyn (αSyn^(pS129))-positive inclusions in the substantia nigra of end-stage postmortem Parkinson's disease brain. Here we show that somatic αSyn^(pS129) inclusions in nigral dopaminergic neurons are consistently fibrillar, whereas the membranous-type...