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Plasticity and language in the anaesthetized human hippocampus
Non-invasive profiling of the tumour microenvironment with spatial ecotypes
Foreshock-induced slip transients set mainshock nucleation timing
Electrocaloric effects across room temperature in multilayer capacitors
Pollinators support the nutrition and income of vulnerable communities
RNA-triggered cell killing with CRISPR–Cas12a2
Expanding the human proteome with microproteins and peptideins
Two-qubit logic and teleportation with mobile spin qubits in silicon
Anaesthetized brains can still process podcasts
Author Correction: Multidimensional profiling of heterogeneity in supratentorial ependymomas
Are attention spans really shrinking? What the science says
AI agents may be skilled researchers—but not always honest ones
Two high-profile tools have been shown to make up data and “p-hack” their results
Astronomers unlock a sharper view from JWST using a ‘keyhole’ trick
A revived technique could reveal planets near their stars and the inner workings of galaxies
Core of Solar System’s largest moon may still be forming
Ganymede discovery could force rethink of how worlds power their magnetic fields
Cruise ship’s hantavirus outbreak puts researchers in uncharted territory
Questions about the culprit virus and its route of spread remain as health officials make plans for stranded passengers
Cell- and state-specific plasticity of striatal glutamatergic synapses is critical to the expression of levodopa-induced dyskinesia
Levodopa-induced dyskinesia (LID) is a debilitating complication of symptomatic therapy in Parkinson's disease. Although there is compelling evidence that striatal pathophysiology is a major driver of LID, the specific circuit mechanisms governing its expression remain obscure. To address this gap, molecular, cellular, and behavioral strategies were used to interrogate circuits in a mouse model of LID. These studies revealed that LID induction led to an upregulation of GluN2B-containing...
Microplastics as an emerging environmental pollutant potentially leading to neurodegenerative diseases
Microplastics (MPs), defined as plastic fragments less than 5 mm in diameter, are ubiquitous in the environment. As an emerging environmental pollutant, MPs can infiltrate the human body through multiple pathways, including inhalation, ingestion, dermal contact and bloodborne transmission.Correspondingly, MPs, which can penetrate the blood-brain barrier and enter the central nervous system (CNS), have been linked to the development of neurodegenerative diseases (NDs).In this review, we provide a...
A rule-based simulation model illuminates the role of asymmetric mitochondrial fission on beta-cell health
Mitochondrial dynamics play a critical role in the development of aging-related diseases such as type 2 diabetes mellitus. To investigate how mitochondrial dynamics influence cellular behavior in pancreatic beta-cells, we developed a rule-based, multi-level simulation model of insulin secretion. The pancreatic beta-cell model encompasses metabolic pathways (glycolysis and oxidative phosphorylation), compartmental processes (mitochondrial fusion and fission), and cellular processes (insulin...
Age-related differences and common pathways of lymphocyte subsets in sepsis: a comparative review of elderly and pediatric patients
Sepsis disproportionately affects older adults and children, two immunologically vulnerable extremes of age. Yet sepsis is superimposed on distinct baselines-immunosenescence in the elderly and immune immaturity in neonates and young children-leading to different pathways toward immune failure. This comparative narrative review synthesizes clinical and experimental evidence on age-specific and shared alterations in lymphocyte subsets in sepsis, including lymphopenia; CD4^(+) and CD8^(+) T cell...
Modifiable risk factors attenuated longevity genetic predisposition on life expectancy in the oldest old
In this prospective cohort study of 1545 participants aged 80 years and older from the China Hainan Centenarian Cohort Study, we investigated the independent and joint associations of modifiable risk factors and genetic predisposition with life expectancy. A weighted modifiable risk factor score (MRFS) based on 11 factors and a polygenic risk score (PRS) for longevity were constructed. A favorable modifiable risk factor profile (low MRFS) was associated with a 40.7% lower death risk (HR 0.593,...