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DNA is most often found in its canonical B-form double-helical structure, but can also adopt alternative conformations, known as non-B DNA structures. Numerous non-B structures have been characterized, including G-quadruplexes, i-motifs, Z-DNA, hairpins, cruciforms, slipped structures, R-loops, and H-DNA. Non-B DNA motifs are enriched in functional regions, including near transcription start and end sites, topologically associated domains, and replication origins, suggesting their importance in...

Unusual “hood” is the first known biological armor that protects against traumatic brain injury

Iron salt toothpaste darkened pearly whites

Current single-cell metabolomics approaches are limited by insufficient sensitivity, robustness and metabolite coverage. We present an ion mobility-resolved mass cytometry technology that integrates high-throughput single-cell injection with ion mobility-mass spectrometry for multidimensional metabolomic profiling. Ion mobility-enabled selective ion accumulation and cell superposition-based amplification strategies substantially enhance sensitivity, robustness and overall analytical performance....

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Synaptic aging is a core manifestation of brain aging arising from the convergence of fundamental biological aging processes, including genomic instability, loss of proteostasis, mitochondrial dysfunction, oxidative stress, and chronic low-grade inflammation. As highly energy-dependent and protein-rich sites of neuronal communication, synapses are particularly vulnerable to age-associated molecular stress. Accumulating evidence indicates that age-related impairments in synaptic vesicle...

CONCLUSIONS: This study highlights a shift in elderly needs from basic care to personalized and ongoing health management. Community-embedded care should prioritize must-be and one-dimensional attributes while addressing the diverse needs of older adults with varying self-care abilities to better support aging in place.

CONCLUSION: Symptoms are highly prevalent among older men and significantly associated with lower HrQoL and pain, tiredness, depression, and anxiety were the most impactful. These findings underscore the importance of targeted symptom screening and management to promote healthy aging and well-being.