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How a steady drip-drip can erode the hardest stone
Operational Tropical Cyclone Forecasting with AI
AI agents are checking the scientific literature — and spotting decades-old errors
Pumas are drivers’ guardian angels
Dirty air may trigger painful rheumatoid arthritis flares
Tiny pollution particles from smoke, soot, and dust may worsen rheumatoid arthritis and raise the risk of painful flares, particularly after prolonged exposure. The findings suggest that avoiding poor air quality could become an important part of managing the disease.
THC medication made PTSD nightmares disappear for more than a third of patients
A prescription form of THC helped many people with PTSD escape recurring trauma-related nightmares, with more than one-third reporting that the nightmares disappeared completely after ten weeks. The results could point toward a long-awaited treatment for one of PTSD’s most distressing and stubborn symptoms.
Global warming is coming for the countryside
Pioneering study projects rural heat will edge closer to city swelter
DNA reveals the hidden past of North America’s bison—and keys to their future
Scientists are racing to conserve what remains of these majestic animals’ genetic diversity
Sitting up straight may improve your mood and decision-making
A simple change in posture may subtly affect how people feel and make decisions. Participants who sat upright reported greater feelings of pride and took more successful risks in a virtual balloon game than those who hunched over. Most did not realize researchers had influenced their posture, helping rule out the possibility that they were merely responding to expectations. The results suggest workplace ergonomics could influence more than physical comfort.
Scientists discover the brain cells that keep you motivated
A group of brain cells called orexin neurons appears to help us keep working when reaching a reward becomes increasingly difficult. Blocking their activity weakened motivation in rats, pointing to a possible new target for understanding why people sometimes struggle to sustain goal-directed behavior.
Astrophysicists find best evidence yet that galaxies get some spin before birth
New study spots “primordial spin” imprinted on galaxies by churning halos of dark matter
Neanderthal growth gene turns modern humans into muscle heads
People with DNA variant from our evolutionary cousins tend to have more lean muscle mass
COVID-19 can wake up dormant viruses in the body, large study confirms
Virus reactivations by SARS-CoV-2 could worsen initial symptoms and increase risk of Long Covid
When less is more and when it isn't: Microglial Spi1 and the limits of what we know
Microglia are key players in Alzheimer's disease, but the transcriptional control of their phagocytic function remains unclear. Kim et al. show that mouse microglial Spi1 deletion worsens amyloid pathology by impairing Aβ clearance through Syk, Lyn, and Fcgr1, providing new insight into PU.1-dependent regulatory networks and microglial functions in neurodegeneration.
Corpora amylacea profiling reveals disease stage and brain region-specific alterations in glycogen metabolism in Alzheimer's disease patient brains
Increasing evidence indicates that shifts in brain polysaccharide metabolism can influence the progression of multiple neurodegenerative diseases. Here, we profile corpora amylacea (CA) in 230 postmortem human brains, revealing significantly higher densities in Alzheimer's disease (AD) patients when compared with patients with other or no neurodegenerative diseases and a tight correlation of CA density with neurofibrillary tangle (NFT) pathology. Immunohistochemical profiling using an...
Mitochondrial homeostasis dysregulation: Potential mechanisms of Alzheimer's disease mediated by TDP-43
Alzheimer's disease (AD) exhibits substantial clinical and pathological heterogeneity that is not fully explained by amyloid-β and tau pathology alone. TAR DNA-binding protein 43 (TDP-43) is increasingly recognized as a frequent copathology in AD, particularly in limbic regions, where its presence is associated with accelerated cognitive decline. Disruption of mitochondrial homeostasis is also an early and consistent feature of AD and contributes to neuronal vulnerability. In this review, we...
Genetic interactions between PIWI subfamily genes and hobo transposons modulate Drosophila melanogaster lifespan under chronic low-intensity irradiation
In recent decades, there has been active research into how ionizing radiation at low doses, an inevitable factor in human activity, affects aging processes and which molecular genetic mechanisms underlie this influence. This study investigates the effects of mutations in PIWI subfamily genes (piwi and aub), which regulate transposable elements, on the lifespan of Drosophila melanogaster under conditions of genome instability induced by hobo transposons and chronic low-intensity irradiation (20...
P-selectin delineates conserved functional heterogeneity in early hematopoietic stem cell aging in humans and mice
Progressive aging of bone marrow hematopoietic stem cells (HSCs) underlies clonal hematopoiesis and age-associated hematologic disorders. Defining early molecular events driving HSC functional decline is essential for rejuvenation strategies. Here, we identify P-selectin (Selp) as a surface marker that stratifies HSCs into conserved functional and transcriptional states during organismal aging in humans and mice. P-selectin expression increases early during aging and remains elevated in old...
Dopamine depletion in Parkinson's increases directed but not random exploration
We investigated how patients with Parkinson's disease (PD) manage the explore-exploit trade-off in a structured reward-learning task. Patients were tested either on (n = 34) or off (n = 34) dopaminergic medication (levodopa), with age-matched polyneuropathy patients serving as controls (n = 35). Behaviorally, patients off medication showed marked learning and decision-making deficits, characterized by overexploration (excessive sampling of novel options) and insufficient exploitation...
Lifestyle and psychosocial protective factors drive healthy aging and modulate inflammatory and metabolic pathways
Lifestyle habits, cognitive reserve, and affective reserve (secure attachment, extraversion, psychological resilience) predict resilience in the oldest-old, though the underlying biological mechanisms remain unclear. This study explored relationships between these protective factors, 120 + NULISA CNS blood biomarkers, and multidimensional health outcomes (global cognition, mental health, walking speed) in 401 dementia-free participants (age 83-87) from the InveCe.Ab study. Using sparse partial...