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Researchers have developed a revolutionary microscope that uses an incredibly powerful laser to make previously invisible cellular structures easier to see. The technology dramatically improves image clarity, allowing scientists to examine small proteins that conventional electron microscopes struggle to capture. It could eventually reveal how tiny molecular machines interact inside cells, providing an unprecedented look at the hidden workings of life.

Your morning coffee may be packing more calories than you realize, and sugar isn't the biggest reason. A study of 30,000 Americans found that non-dairy creamer has overtaken sugar and milk as the leading source of added coffee calories, helping drive a nearly 40% increase between 2003 and 2018.

Scientists have discovered why common marmosets have unusually small, smooth brains despite starting development much like other primates. The secret lies in subtle changes to brain-building cells that slow neuron production, revealing new clues about how the large, folded human brain evolved.

In Alzheimer's disease (AD), activation of the mechanistic target of rapamycin (mTOR) pathway promotes microglial neuroprotective functions by engaging multiple cell receptors. However, the relevant downstream effectors are not fully understood. mTOR complex 1 (mTORC1) promotes mRNA translation by phosphorylating and inactivating eukaryotic translation initiation factor 4E-binding protein 1 and 2 (4E-BP1/2), which are expressed in microglia. 4E-BP1 levels in cerebrospinal fluid (CSF) are...

Retrospective studies in patients with nonmuscle invasive bladder cancer have reported a significant reduction in Alzheimer's disease incidence (12 to 78%) among Bacille Calmette-Guérin (BCG) recipients versus controls. To investigate the underlying mechanisms, we evaluated BCG in the PS19 mouse model of tauopathy. We found that BCG administration reduced hippocampal phospho-tau and microgliosis while preserving neuronal markers. In vivo volumetric T2-magnetic resonance Imaging (MRI)...

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Inflammaging, a state of chronic low-grade inflammation, is a key contributor to biological aging and diabetes. Traditional inflammatory indices within the interplay between inflammation and epigenetic aging remain insufficiently explored. In addition, novel platelet-based inflammatory indices may perform better than traditional inflammatory indices. This study was a cross-sectional study with survival analysis and analyzed data from 2494 participants in the National Health and Nutrition...

Neuronal senescence, triggered by oxidative stress and inflammatory responses, is a significant risk factor for brain aging, ultimately leading to cognitive decline. Apelin-13, an exercise-induced myokine, exhibits potential neuroprotective effects by the APJ system, but its protective effects against neuronal senescence and the underlying mechanisms are unknown. This study aimed to elucidate how apelin-13 prevents D-galactose-induced neuronal senescence in SH-SY5Ys, human induced pluripotent...

Moderately cold temperatures extend lifespan and promote health across species^(1-3), yet the molecular mechanisms underlying these benefits remain unclear. Here we define a metabolite-driven, multi-tissue signalling system that links cold temperature to enhanced longevity and proteostasis in Caenorhabditis elegans. Cold temperature upregulates the biopterin-synthesis enzyme CAT-4 (GCH1 in humans), increasing production of dihydrobiopterin (BH2), a transportable reservoir for the bioactive...

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CONCLUSION: While dietary diversity improved similarly in both arms, the intervention-specific improvement in LLMS - a parameter associated with functional capacity - suggests the ALAPAGE program has potential as a preventive public health approach for contributing to healthy aging in community-dwelling older adults.

CONCLUSIONS: Older people with Parkinson's described contending with the progressive nature of Parkinson's and the erosion of independence, while informal caregivers reported the physical, emotional and financial burden of caregiving. Care work was becoming more difficult, yet families in this study demonstrated adaptability, resilience and enduring obligation to enact and reciprocate care. This study emphasises the need to strengthen, support and sustain community-based approaches to care for...

CONCLUSION: A substantial proportion of stroke survivors did not achieve the targets recommended by the ESO for secondary prevention. In the older people population, fewer patients reached optimal blood pressure control, and anticoagulant use among those with atrial fibrillation was suboptimal. Our findings highlight the need for structured post-stroke follow-up pathways, improved communication between stroke specialists and primary care physicians, and targeted interventions to optimize...

CONCLUSION: This cross-sectional study found a significant association between proximity to major roadways and prevalent diabetes in Chinese older adults. Roadway proximity acts as a composite surrogate marker of traffic hazards, neighborhood socioeconomic deprivation and built environments, rather than merely traffic pollution or noise. These findings guide future environmental and health equity research on seniors. Longitudinal studies with objective exposure measurements are required to...

Nicotinamide adenine dinucleotide (NAD^(+)) is an essential metabolite that regulates diverse cellular metabolic processes. Primary cilia, hair-like organelles on the cell surface, function as critical signaling hubs. Here, we demonstrate that cellular NAD^(+) levels are key regulators of both primary cilia growth and lysosomal function in hypothalamic neurons. NAD^(+) depletion induces ciliary shortening and diminishes lysosomal activity in a cilia-dependent manner. Mechanistically, the...

Calcific aortic valve disease (CAVD) is an age-associated valvular disorder in which calcification expands from discrete foci into adjacent tissue. We investigated whether mitochondrial-derived vesicles (MDVs) released by human valvular interstitial cells (hVICs) exert pro-calcific effects on recipient cells and how MDV release is regulated. Using ex vivo hemodynamic perfusion of human CAVD tissue, multi-omics profiling, live-cell single-organelle tracking, MDV transfer assays, and in vivo Gas6...

Patients with idiopathic pulmonary fibrosis (IPF) are highly vulnerable to respiratory virus infections, but the cellular mechanisms linking fibrotic remodeling to impaired local antiviral defense remain unclear. Here, we investigated how cellular senescence shapes the response of patient-derived healthy (HLF) and IPF primary lung fibroblasts to influenza A virus (IAV) infection. Transcriptomic profiling identified infection as the driver of gene expression in both DNA damage-induced senescent...

INTRODUCTION: Easy-to-Read (E2R) formatting is widely recommended to improve reading accessibility, yet whether its typographic and structural features benefit visual processing and comprehension across the adult lifespan remains unclear.

CONCLUSION: Social engagement appears to be a critical pathway to health, even if sedentary. Nonetheless, natural spaces are chosen environments for a range of OOH activities. We recommend neighbourhoods be designed with multifunctional natural spaces to encourage mobility during OOH trips, supporting ageing-in-place.