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A distant brown dwarf coplanar to a warm Jupiter and a hot super-Earth
Emergent decadal predictability in Antarctic contribution to sea-level rise
DNA from hunter-gatherer teeth reveals secrets of ancient plague
Towards Conversational AI for Disease Management
These ‘master’ proteins protect us from deadly mutations — and could inspire new drugs
The EU needs to back its ambition to end animal testing with cash
Should nicotine be regulated like a narcotic? A Pacific nation makes the case
New procedure delivers lasting knee arthritis pain relief without surgery
A minimally invasive treatment that blocks inflammation-driving blood vessels in the knee provided significant pain relief and improved function for osteoarthritis patients, with benefits lasting at least a year. The procedure was safe, highly successful, and could offer a new alternative for people seeking relief before considering knee replacement.
Scientists say most of what’s in your food is still a mystery
Scientists are beginning to explore a hidden world of thousands of food chemicals that go far beyond the nutrients listed on nutrition labels. This “nutritional dark matter” may hold the key to understanding disease risk, healthy aging, and why different diets affect people in dramatically different ways.
New space telescope will map galaxies’ ghostly halos and streams
European Space Agency mission will trace the relics of ancient mergers and probe the dark matter shaping galaxy growth
Scientists found an early depression clue hidden in children’s eyes
Depression appears to change what children notice in the faces around them, but the effect depends on family history. Kids with a higher inherited risk became more focused on sadness, while lower-risk children lost some of their natural attention to happy expressions.
10 surprising ways diabetes and dementia are connected
Diabetes and dementia appear to be closely intertwined, with each condition potentially influencing the other. Problems with insulin and glucose can affect the brain’s energy supply, increase inflammation, and damage blood vessels linked to memory loss. Researchers are also finding that some popular diabetes medications may lower dementia risk. These discoveries are opening new possibilities for protecting brain health as people age.
Do animals perceive time differently from humans?
Science chats with a researcher whose team is using “timescapes” to understand how nonhumans experience the world
New study explores potential cross-species spread of chronic wasting disease
A new study found that chronic wasting disease can sometimes spread silently, with infectious prions present even in animals that show no symptoms. While there is no confirmed human risk, researchers say the disease’s ability to evolve and spread across species warrants close attention.
Most people who stop GLP-1 drugs like Ozempic eventually return
Many people prescribed GLP-1 drugs for type 2 diabetes (such as Victoza, Ozempic, or tirzepatide) stop taking them, but a surprising number later return to treatment. Researchers found that newer medications appear to keep patients on therapy longer, while side effects remain a major reason for discontinuation.
Semaglutide (Ozempic) linked to fewer bone fractures despite greater weight loss
A large real-world study suggests semaglutide (Ozempic, Wegovy, Rybelsus) may offer an unexpected bonus for people with type 2 diabetes: stronger protection against bone fractures while delivering greater weight loss. Researchers analyzing health records from nearly 60,000 adults found that people taking semaglutide experienced about 15% fewer fractures than those using other common weight-loss medications, despite losing more weight.
Interpretable graph-based models on multimodal biomedical data integration: a technical review and benchmarking
Integrating diverse biomedical modalities is essential for robust healthcare insights, and graph-based models are increasingly used to capture complex relational structures. Yet, their clinical translation hinges on interpretability. This review surveys interpretable graph-based models applied to multimodal biomedical data, highlighting dominant trends in disease classification, static graph construction, and post-hoc explainability. We categorize explainable artificial intelligence (XAI)...
Multi-omic analysis of deep learning-derived phenotypes links ophthalmic imaging to cardiovascular and neurological traits
The eye is a recognized source of biomarkers for cardiovascular and neurodegenerative disease risk. Here we characterize the breadth of these associations and identify biological axes that may mediate them. Using UK Biobank data, we developed a multi-omic analysis pipeline integrating physiological, radiomic, metabolomic and genomic information. We trained retinal adversarial autoencoders to represent optical coherence tomography images and color fundus photographs as 256-dimensional embeddings....
Human iPSC-NSC-Derived Extracellular Vesicles Can Alleviate Alzheimer's Disease-Linked Impairments in Mitochondria, mTOR Signaling, Autophagy, and Hippocampal Neurogenesis
Intranasal (IN) administrations of extracellular vesicles (EVs) derived from human-induced pluripotent stem cell (hiPSC)-derived neural stem cells (hNSCs) have shown promise in reducing chronic neuroinflammation mediated by microglia and astrocytes in 5x familial Alzheimer's disease (5xFAD) mice, a model for early-onset Alzheimer's disease (AD). The current study rigorously investigated whether treatment with hiPSC-NSC-EVs could also alleviate several other neuropathological changes contributing...
Mitochondria and brain aging: From cell-specific dysfunction to intercellular cooperation
Mitochondria are essential for brain energy metabolism and are increasingly recognized as key contributors to brain aging. Although neurons are exceptionally vulnerable to age-related mitochondrial decline, emerging evidence reveals that glial and vascular cells also exhibit distinct mitochondrial impairments. This review synthesizes recent advances in our understanding of mitochondrial dysfunction across specific brain regions and diverse cell types, highlighting subcellular...