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Find in Spanish cave provides rare window into the domestic lives of our closest relatives

New controls could limit papers by early-career researchers

Cannabinoids may intensify anxiety by removing a natural brake on specific neurons in the brain’s fear center, particularly during stressful situations. In mice, shutting down those neurons sharply reduced cannabinoid-related anxious behavior.

Colorectal cancer in young people is often diagnosed at an advanced stage, with researchers finding most patients age 21 or younger already had Stage III or IV disease. Because symptoms like rectal bleeding, weight loss, abdominal pain, and bowel changes may be overlooked, researchers are calling for greater vigilance.

Scientists have found a surprising way to regrow damaged knee cartilage by blocking a protein that becomes more abundant with age. In old mice, the treatment restored naturally lost cartilage and also helped prevent osteoarthritis after ACL-like knee injuries, while human cartilage taken from knee replacement patients began producing new, functional joint cartilage after exposure to the same inhibitor.

Couples who exercise together report better communication, healthier conflict resolution, and lower marital stress than those who work out alone. Even something as simple as taking a walk together may create valuable opportunities to talk, listen, and feel more connected.

New mothers paired with patient navigators were much more likely to receive postpartum care, depression screening, preventive testing, and ongoing primary care. By helping with barriers such as transportation, childcare, scheduling, and confusing medical information, navigators may provide a powerful way to improve women’s long-term health.

Nutritional status and metabolic homeostasis are intricately associated with the inflammatory response. However, the direct mechanistic link between nutrition, metabolism and inflammation remains unclear. Here, we show that the amino acid L-arginine (L-Arg) is a potent endogenous inhibitor of the NLRP3 inflammasome, a central component of the inflammatory signalling pathway. We show that L-Arg binds directly to the Asp31 site of the NLRP3 protein, blocking its interaction with the adaptor ASC...

Understanding how genetic influences on complex traits change with age is a fundamental question in genetic epidemiology. Both cross-sectional (between-subject) and longitudinal (within-subject) approaches can contribute to answering this question but come with distinct strengths and limitations. Here we show that age-varying genetic effects obtained from the two designs were highly concordant in direction (84.21% of the 57 identified variants) but showed only moderate agreement in effect-size...

Aging drives molecular changes that impair cellular and tissue function. Lipids are central to membrane structure, signaling and energy storage, yet their remodeling during aging remains unclear. Here, using cross-species, multi-tissue lipidomics, we identify elongation of lipid acyl chains as a conserved hallmark of aging across mice, Caenorhabditis elegans, Drosophila and humans. Similar lengthening occurs during the progression of human heart disease, whereas dietary restriction shortens...

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Cognitive decline in Parkinson's disease (PD), progressing from mild cognitive impairment (PD-MCI) to severe dementia (PD-D), is a debilitating core feature driven by complex neuropathological interactions. While α-synuclein accumulation is the disease's hallmark, co-pathologies involving amyloid-β and tau, alongside chronic neuroinflammation, are critical accelerators of cognitive collapse. This review positions the receptor for advanced glycation end products (RAGE) as a key molecular...

Anti-amyloid antibodies substantially reduce amyloid plaque burden, yet the resulting cognitive benefit remains modest, exposing a limitation in the conventional storage-and-deletion model of memory. We propose that Alzheimer's disease (AD) is better understood as a progressive failure of the dynamic processes that continuously reconstruct memory and bind it to conscious experience, rather than static deletion of stored content following synaptic loss. Amyloid-beta oligomers and mislocalized tau...

Higher-order chromatin structure is linked to cell differentiation and aging, but its native distribution in tissues and role in organismal development remain unclear. Here, we introduce SpaceA, a spatial omics approach for in situ chromatin architecture profiling. Compared with high-throughput chromosome conformation Capture (Hi-C), SpaceA captures substantially more contacts over distances beyond 10 Mb, thereby enhancing detection of higher-order chromatin dynamics. Applied to nine mouse...

Atherosclerotic cardiovascular disease (ASCVD) remains a leading cause of morbidity and mortality, with substantial residual risk persisting despite contemporary lipid-lowering, antithrombotic, and anti-inflammatory therapies. Increasing evidence indicates that vascular smooth muscle cells (VSMCs) actively shape plaque composition, progression, and stability through cellular programs that partially resemble those involved in tumor evolution. Within this framework, tumor-like transformation...

Aging is characterized by profound biological changes, among which epigenetic remodelling -encompassing alterations in DNA methylation patterns and microRNA modulation - and inflammaging (chronic, low-grade systemic inflammation) represent major contributors to functional decline and the pathogenesis of age-related diseases. While increasing evidence suggests a complex interplay between epigenetic modifications and inflammaging, a comprehensive elucidation of this axis remains elusive. In this...

This study examined short-term trends in the prevalence of major chronic diseases, multimorbidity patterns, and of healthy aging levels among older adults participating in free health checkups in Longhua District, Shenzhen, from 2022 to 2024. Using random sampling, 10,000 participants were selected annually from the elderly health management information system, and both crude and age-standardized rates were calculated. Changes in prevalence were assessed using the Mantel-Haenszel test and...

CONCLUSION: Together, these findings indicate that lifespan divergence in N. furzeri is associated with distinct mitochondrial aging trajectories, supporting that enhanced antioxidants defenses and mitochondrial quality control contribute to the preservation of brain mitochondrial homeostasis and increased longevity.