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Atherosclerotic cardiovascular disease risk is associated with AT(N)V neuroimaging biomarkers and cognitive impairment in the health and aging brain study-health disparities cohort
CONCLUSION: In this diverse HABS-HD sample, increasing ten-year ASCVD risk was associated with greater AT(N)-V biomarker burden and poorer cognitive performance across multiple domains. These cross-sectional findings suggest that ten-year ASCVD risk may serve as a marker of co-occurring cardiovascular and brain health burden, but they do not establish causality or temporal direction.
Memory stays strong in old age when this brain enzyme is active
No abstract
Chaperone-mediated autophagy curbs senescence
No abstract
Established determinants of replicative lifespan, including mitochondrial DNA, play a limited role in early yeast stress-resistance decline
Baker's yeast is a long-standing model for studying mechanisms of aging. Due to asymmetric division, yeast mother and daughter cells are distinguishable, and mother cells usually cease division after 15-25 budding events. However, yeast suspensions consist predominantly of young cells. Here we investigated whether, under harsh environmental conditions, replicative aging-defined by the number of buds produced-manifests at early replicative ages. To test this, we adapted a flow-cytometry-based...
Scientists find a way to fight Alzheimer’s brain damage without removing toxic tau
Scientists have found a promising way to protect the brain from Alzheimer’s-related damage by blocking immune cells that contribute to the destruction of neurons. In mice, the treatment preserved roughly 40% more tissue in memory centers and improved memory, even without removing harmful tau protein buildup.
Biologist David Sabatini wins $6 million in defamation lawsuit
A jury ruled in favor of the former Whitehead Institute scientist, dismissing accuser’s claims of sexual harassment and retaliation