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A massive study of more than 120,000 older adults suggests that common osteoporosis drugs may reduce the risk of Alzheimer’s disease and other dementias by up to 24%. The surprising findings raise the possibility that medications already used to strengthen bones could also help protect the aging brain.

Brain organoids offer highly efficient processing—if researchers can learn how to harness their power

New policy draws tempered praise from biosecurity experts

Scientists have discovered that a buildup of a protein called Miro1 may be a hidden driver of insulin resistance in Type 2 diabetes, with preclinical experiments showing that removing it restores the muscles’ response to insulin. Exercise was also found to lower Miro1 levels in people with diabetes, revealing a potential new pathway for treating the disease.

Scientists at UC San Francisco have developed a powerful new cancer therapy that remains inactive until it reaches the brain, where it switches on to attack deadly tumors. The engineered immune cells, called B-SYNC CAR-T cells, completely eliminated diffuse midline glioma (DMG), an aggressive childhood brain cancer that is almost always fatal within a year, in two mouse models.

More than a century after Einstein revolutionized our understanding of gravity, scientists have uncovered a surprising new phenomenon hidden within his equations. Researchers at Columbia University and Universidad Adolfo Ibáñez have identified a theoretical process called "gravitational reconnection," in which structures within gravitational fields can break apart and reconnect, transferring energy into matter.

Scientists have discovered that fasting for just 24 hours increases a beneficial gut bacterium that helps the intestines regenerate after radiation damage. The preclinical findings could pave the way for new treatments that protect healthy tissue during cancer therapy, potentially without requiring patients to fast.

CONCLUSION: Falls were associated with several demographic, socioeconomic, health-related, sensory, cognitive, and functional factors. These findings highlight the need for comprehensive fall-prevention strategies that address modifiable risk factors to reduce the burden of falls in aging populations.

CONCLUSIONS: Meaningful participation of older adults in DT for AI-driven assistive technology is methodologically and ethically important for producing acceptable, usable, and contextually appropriate technology. This evidence map offers guidance for geriatric researchers, clinicians, digital-health implementers, and policymakers committed to inclusive co-design with older adults, and identifies priority gaps for future primary research.

CONCLUSIONS: The results highlight the importance of health and social context in shaping life satisfaction in later life and suggest the need for integrated interventions supporting both physical and mental well-being among older adults.

Terrestrial ecosystems maintain a stable time-allocation budget between growth and senescence, but whether this applies to the ocean remains unclear. Using fused satellite LiDAR and ocean-color data (2007-2022), we show that marine phenology is variable and asymmetric. In high latitudes ( > 50°N), the bloom growth-to-decline ratio (R(GD)) is declining by ~5.3% per decade. While the chlorophyll-increase phase has lengthened by 2.3-5.5 days, the post-peak chlorophyll-decline phase has extended...

Cardiovascular disease (CVD) is the leading cause of mortality worldwide, and cellular senescence serves as a core driving factor in the pathogenesis and progression of cardiovascular degeneration and related diseases. Sirtuins act as a crucial molecular hub linking cellular senescence to CVDs, and their upregulated activity is closely associated with delayed cellular senescence and preserved normal cardiovascular function; therefore, the research and development of small-molecule...

Aging leads to significant hair changes, including alopecia and graying, yet the underlying mechanisms remain unclear. Emerging evidence highlights the role of the extracellular microenvironment, particularly dermal white adipose tissue (dWAT), in regulating hair regeneration and pigmentation. Previous studies showed that young murine dWAT improves age-related hair phenotypes via follistatin upregulation. This study investigates key molecular mechanisms in dWAT governing hair aging, aiming to...

MIT scientists have developed nanoparticles that reprogram immune cells directly inside the body to attack cancer and harmful immune cells, eliminating tumors and reversing liver damage in mouse experiments. The breakthrough could make powerful immune therapies dramatically simpler and less expensive while opening new possibilities for treating cancer and autoimmune diseases.

A major international study tracking more than 26,000 men found that very low testosterone levels were associated with an 18% higher risk of dying from cancer later in life. Surprisingly, testosterone itself showed no clear link to prostate cancer, although two other sex hormones did. Researchers believe low testosterone could be an important early warning sign of future health risks, particularly when levels fall below 8.6 nmol/L.

Scientists have discovered that sleep disorders are associated with structural changes in brain regions that control attention, decision-making, and emotions, potentially explaining why disrupted sleep can affect everyday thinking and behavior. The findings, drawn from 57 brain imaging studies, reveal both shared and disorder-specific patterns that could lead to more targeted treatments.

A surprising new study suggests that a stronger flu shot could offer older adults significantly greater protection against Alzheimer's disease. Researchers at UTHealth Houston analyzed nearly 200,000 adults ages 65 and older and found that those who received a high-dose influenza vaccine had a nearly 55% lower risk of developing Alzheimer's, compared with a 40% reduction previously associated with the standard-dose vaccine.