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Following nearly 10,000 older women for 10 years, researchers found that tea drinking was associated with slightly higher hip bone density. Moderate coffee consumption did not appear harmful, but drinking more than five cups a day was linked to lower bone density. The findings suggest tea may offer a small bone-health boost, while excessive coffee could carry some drawbacks.

Where you live in early adulthood may quietly shape your heart health for decades. Researchers found that adverse neighborhood conditions were linked to a higher risk of coronary artery calcification in midlife, an early warning sign of cardiovascular disease.

Obesity appears to leave a molecular imprint on key immune cells that may persist for 5 to 10 years after weight loss. This long-lasting “obesity memory” could help explain why some obesity-related health risks remain elevated even after body weight returns to normal.

Newly recovered sheeppox sequences reveal when and how the virus emerged

Mindfulness, gratitude, and optimism training may improve blood pressure, inflammation, and other heart-health measures within just eight to 12 weeks. The strongest programs paired daily practice with regular reinforcement, suggesting that improving psychological well-being could become another tool for protecting cardiovascular health.

A study of people over 90 found that dementia risk remains strongly shaped by sex, race and genetics, with women and black participants facing notably higher risks. Intriguingly, some people stayed cognitively healthy despite carrying major risk factors, potentially offering clues to how the brain can resist dementia deep into old age.

To enable widespread adoption of electric vehicles, positive-electrode materials must fulfill high energy, long-term stability, and earth-abundant composition within large-format architectures. Lithium-manganese-rich layered oxides show promise through high energy enabled by oxygen redox chemistry and abundant manganese content while minimizing cobalt content. However, oxygen redox irreversibility and gas evolution present challenges in its adoption to large-format cells. Here, we reveal how...

The structural integrity of layered VOPO(4) frameworks critically determines their electrochemical performance in aqueous zinc-ion batteries, yet the highly ordered stacking of VOPO(4) renders it susceptible to lattice stress accumulation and chemo-mechanical degradation during cycling, causing rapid capacity fading and a shortened battery lifespan. Herein, we show a strategy to alleviate these limitations through partial metal substitution in the VOPO(4) lattice, enabling the modulation of...

Alzheimer's disease (AD) is a progressive neurodegenerative disorder whose pathological course involves amyloid-β (Aβ) deposition, tau abnormalities, neuroinflammation, and neurovascular dysfunction. Interest in the microbiota-gut-brain axis does not arise because gut dysbiosis has been established as an independent initiating cause of sporadic AD, but because this axis connects modifiable peripheral factors-including diet, medication, ageing, and intestinal physiology-with barrier homeostasis,...

Navigating uneven terrain poses a significant challenge for older adults, often resulting in falls. Identifying the neural correlates of walking on uneven terrain might help understand the mechanisms of age-related mobility decline. We examined age and physical function group differences in white matter microstructure and tested whether associations between white matter measures and uneven-terrain walking behavior differed between these groups. Twenty-two young adults (22.45 ± 2.58 years) and 86...

Whether reversal of biological age and/or aging is possible is among the most actively debated topics in the field of aging. Here, we consider the meaning of biological age reversal and its burden of proof, focusing on foundational issues and the language we use to debate these questions.

Alzheimer's disease (AD) is a progressive neurodegenerative disorder whose pathological course involves amyloid-β (Aβ) deposition, tau abnormalities, neuroinflammation, and neurovascular dysfunction. Interest in the microbiota-gut-brain axis does not arise because gut dysbiosis has been established as an independent initiating cause of sporadic AD, but because this axis connects modifiable peripheral factors-including diet, medication, ageing, and intestinal physiology-with barrier homeostasis,...

Ageing research has undergone a paradigm shift from descriptive theories to a mechanistic understanding grounded in the interconnected biological processes. This work synthesizes the current landscape of ageing research, emphasizing the critical role of biomarkers in translating mechanistic insights into clinical application. Biomarkers, ranging from molecular and cellular markers to functional and imaging parameters, serve as essential tools for quantifying biological age, assessing the...

Sarcopenia has consensus criteria on three continents and an all-cause mortality hazard ratio near 1.6, yet no drug is approved for the primary age-related condition and agents that reliably enlarge muscle have not improved the strength and gait-speed endpoints that define it. We approach this translational failure from the biology rather than the pipeline. Ageing degrades four properties of skeletal muscle that jointly determine force production and are each druggable in principle: innervation,...

Although motor and cognitive functions are closely interconnected in daily life, they are typically assessed separately in fall assessments. This dual-center cross-sectional, observational study examined the discriminative performance of agility and motor-cognitive assessments to distinguish between community-dwelling older adults with and without a history of falls, compared with established motor and cognitive tests. A total of 231 participants (103 with a history of falls; age 71.9 ± 7.5...

Mitochondria are continuously exposed to damage that contributes to aging and disease. While prolongedly damaged mitochondria are eliminated by mitophagy, how cells respond to transient damage remains unclear. Here, we establish a cell-based system to induce transient mitochondrial stress and resolve its recovery dynamics. We identify the E3 ubiquitin ligase mahogunin ring finger 1 (MGRN1) as a damage-threshold sensor that discriminates between transient and prolonged mitochondrial insults....

It’s far too early to declare a discovery, physicists with the LZ detector say

State initiatives this fall and in early 2028 will gauge voters’ appetite for science, but controversy has grown around one proposal