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A single freeze cycle redirects iron mineral transformation
Polycrystalline ice formation concentrates mineral nanoparticles into liquid boundaries between growing ice crystals. Here we show that minutes of freezing dictate iron mineral fate over subsequent months of aqueous aging. A single freeze-thaw cycle irreversibly aggregates ferrihydrite through converging physical and chemical mechanisms. Freeze concentration collapses electrostatic barriers while cryosuction strips hydration layers and compresses nanoparticles into micrometer-scale planar...
Proteostasis Rebalancing by LET-607 Deficiency Promotes Longevity
Disruption of proteostasis is a hallmark of aging. Given that cellular resources are limited, this necessitates a coordinated orchestration of different proteostatic subsystems. Yet, the principles governing this process, including the potential role of trade-offs, are not well defined. Here, we report a trade-off between the endoplasmic reticulum unfolded protein response (UPR^(ER)) and the cytosolic UPR (UPR^(cyto)) in C. elegans that influences lifespan. We find that wild-type animals...
Traditional Disease Risk Factors Outperform Epigenetic Clocks as Predictors of Non-Communicable Disease Morbidity in a Middle-Aged Cohort
DNA methylation-based epigenetic clocks have been highlighted as promising biomarkers of ageing, and they have been shown to robustly predict morbidity and mortality. However, current literature is lacking a formal analysis of the increased prediction accuracy, or the added value, of the epigenetic clocks over traditional risk factors, such as body composition, smoking, or alcohol consumption, in predicting common chronic diseases. Here, we have compared the most commonly used epigenetic clocks...
Age-associated DNA methylation patterns in mouse blood and tail: feasibility of tissue-specific epigenetic clock development
Aging is accompanied by widespread remodeling of DNA methylation (DNAm), which can be leveraged to build epigenetic clocks. In mice, most DNAm clocks rely on internal organs or terminal tissues, limiting longitudinal studies. Here, we compared age-associated DNAm patterns in matched blood and tail-an easily accessible but underexplored tissue-and evaluated both as substrates for tissue-specific DNAm age prediction. Matched blood and tail were collected from male C57BL/6N Per2::Luc mice aged...
NAD(+) modulates REST isoform expression and its downstream mitophagy in Alzheimer's disease
Repressor Element 1-Silencing Transcription factor (REST) emerges as a metabolism-sensitive transcriptional hub that supports basal mitophagy, mitochondrial quality, and synaptic function in neurons. In Alzheimer's disease, REST becomes mislocalized and functionally impaired, coinciding with early defects in mitochondrial quality control. Activation of the NAD^(+) -SIRT1 axis enhances REST nuclear activity, restores its mitochondrial and neuroprotective gene programs, and attenuates pathological...
Distribution, inequalities and associated factors of unmet medical needs among older adults: evidence from the national health service survey
CONCLUSIONS: The UMNs of the older adults and the potential threat to inequalities require the attention of policymakers. Interventions should focus on improving access to medical services, with a particular emphasis on addressing the needs of vulnerable populations.
Building Sustainable Access to Home- and Community-Based Services for Rural Veterans and Older Americans
No abstract
ZBTB7A-mediated regulation of astrocytic glycolysis in neurodegenerative diseases: insights from literature review and bioinformatics prediction
The incidence of neurodegenerative diseases, including Alzheimer's disease (AD), continues to increase with the extension of human lifespan. However, their pathogenesis remains incompletely understood. Altered energy metabolism, particularly glucose metabolism involving glycolysis and oxidative phosphorylation, is widely recognized as an early pathological feature of neurodegenerative diseases. Astrocytes, the most numerous and widely distributed functional cells in the central nervous system...
Daily briefing: Mutation lets octopuses make proteins with precision
Author Correction: A T<sub>reg</sub>-specific long noncoding RNA maintains immune-metabolic homeostasis in aging liver
‘This time, it’s the other way around’: how Indonesia is reclaiming the science of human history
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Graduating without a thesis: meet the people getting ‘practical’ PhDs in China
Found: the toxic killer that caused an ocean catastrophe
Pair of ‘super-puff’ planets are lighter than candyfloss
Bacteria sense virus-induced genome degradation via methylated mononucleotides
Science, Ahead of Print.
Virome-wide ubiquitin ligase discovery reveals diverse mechanisms of immune evasion
Science, Ahead of Print.
Vicinal disubstitution of alkyl C–X synthons via alkene radical cation generation
Science, Ahead of Print.
Autonomous biomedical research with an artificial intelligence agent
Science, Ahead of Print.
A vitamin A discovery is changing what scientists know about vision
A surprising discovery is reshaping scientists' understanding of how humans develop sharp central vision before birth. Instead of blue cone cells migrating away from the retina's center, the study found they transform into red and green cones under the influence of vitamin A-related signals and thyroid hormones. The findings could improve lab-grown retinal tissue and lay the groundwork for future cell therapies to restore vision lost to age-related eye diseases.