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One tiny mutation may explain how bat viruses become human threats

4 days 12 hours ago
Scientists found that one tiny genetic change can completely alter how a coronavirus behaves in different species. Comparing SARS-CoV-2 with a closely related bat-only virus, they showed that a single amino-acid difference affects whether the immune system fights back or gets suppressed. This may help explain how some animal viruses make the leap to humans and become far more dangerous.

The tea in your kombucha changes more than just the taste

4 days 22 hours ago
Scientists discovered that kombucha’s flavor, chemistry, and antioxidant activity vary dramatically depending on the tea used to make it. Green and oolong tea kombuchas emerged as the most biologically active, while fermentation transformed each tea into a distinctly different beverage.

Bromodomain protein 4 (BRD4) as a central epigenetic regulator in neuropsychiatric and neurodegenerative disorders

5 days 3 hours ago
Bromodomain-containing protein 4 (BRD4), a member of the bromodomain and extra-terminal (BET) family, is a central epigenetic regulator that links histone acetylation-dependent chromatin remodelling to transcriptional control. Through recognition of acetylated lysine residues and recruitment of transcriptional machinery, it is increasingly recognised as a critical regulator of neuronal and glial functions, influencing synaptic plasticity, neuroinflammation, learning, memory, and behavioural...
Preeti P Bhagat

Necroptosis in Down Syndrome

5 days 3 hours ago
Necroptosis is a form of controlled cell death implicated in neuronal loss observed in neurodegenerative diseases such as Alzheimer's disease. Down syndrome (DS) is also characterized by the presence of neuronal cell loss, but the underlying mechanisms remain unclear. Brain tissue from a mouse model of DS, Ts65dn mice, and subjects with DS were assessed for levels of necroptosis markers including receptor-interactive protein kinase 1 and 3, necroptosis executor mixed lineage kinase domain-like...
Hymavathi Reddy Vari