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Ageing promotes metastasis via activation of the integrated stress response
Lung cancer predominantly affects older individuals, yet how physiological ageing influences tumour evolution remains poorly understood¹. Here we show that ageing reprograms the evolutionary trajectory of KRAS-driven lung adenocarcinoma, limiting primary tumour growth while promoting metastatic dissemination through epigenetic activation of the integrated stress response (ISR). The ISR effector ATF4 drives epithelial and metabolic plasticity, conferring metastatic competence. Mechanistically,...
Gut microbes affect cognition during ageing
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Daily briefing: A daily multivitamin slows the signs of biological ageing
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Memory loss is fuelled by gut microbes in ageing mice
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Daily briefing: Vaccine-carrying mosquitoes could inoculate bats against rabies
‘Baked, not fried’: five highlights from nutrition research
Youthful antics predict lifespan — at least for these fish
From field experiments to policy interventions at scale
Science, Volume 391, Issue 6790, March 2026.
Erratum for the Research Article “Efficient formation of single-copy human artificial chromosomes”
Science, Volume 391, Issue 6790, March 2026.
Erratum for the Research Article “Acid-humidified CO2 gas input for stable electrochemical CO2 reduction reaction”
Science, Volume 391, Issue 6790, March 2026.
Megabase-scale human genome rearrangement with programmable bridge recombinases
Science, Volume 391, Issue 6790, March 2026.
Polymerase trapping as the mechanism of H5 highly pathogenic avian influenza virus genesis
Science, Volume 391, Issue 6790, March 2026.
Programmable genome editing in human cells using RNA-guided bridge recombinases
Science, Volume 391, Issue 6790, March 2026.
Autophagolysosomal exocytosis inverts Src kinase onto the cell surface in cancer
Science, Volume 391, Issue 6790, March 2026.
Lifelong behavioral screen reveals an architecture of vertebrate aging
Science, Volume 391, Issue 6790, March 2026.
Computational design of conformation-biasing mutations to alter protein functions
Science, Volume 391, Issue 6790, March 2026.
Whole-embryo spatial transcriptomics at subcellular resolution from gastrulation to organogenesis
Science, Volume 391, Issue 6790, March 2026.