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Topographic structure and function of locus coeruleus noradrenaline neurons
Evolution and heterogeneity of lethal metastatic bladder cancer subtypes
Mutational constraints on RSV F and its neutralization by antibodies
Continuous-wave laser absorption spectroscopy of the thorium-229 nucleus
Electroluminescent photoresists extending lithographic scaling to OLEDs
Reimagining research papers as interactive and reliable AI agents
Mitochondrial fission factor senses and governs ferroptosis
Developmental xenocortication using human-derived organoids in mice
Development of a random background to understand ligand optimization
Mechanisms of Transcriptional Regulation by Salicylic Acid Receptors
Inflection points and transitions in Alzheimer’s disease
These bizarre, much-coveted microbes are revealing the origins of complex life
Map of brain ‘microproteins’ could offer new clues to Alzheimer’s disease
Ultra-processed foods linked to hidden muscle fat that may threaten your knees
Eating more ultra-processed foods was linked to greater fat buildup inside thigh muscles, according to MRI scans of 615 adults at risk for knee osteoarthritis. Surprisingly, the association remained even after researchers accounted for calorie intake, physical activity, and other factors. Fatty changes in these muscles may weaken support around the knee and potentially increase osteoarthritis risk.
Scientists find a hidden retinal defense against vision loss
A naturally occurring molecule called erucamide may help the retina fight back against diseases that cause progressive vision loss. Restoring the molecule activated protective immune responses that helped stabilize retinal tissue and slow aspects of degeneration in preclinical models.
Scientists reversed biological age in older adults in just 4 weeks
Older adults who changed the balance of fat, carbohydrates, and animal protein in their diets showed signs of reduced biological age after just four weeks. The strongest result appeared in participants eating an omnivorous, lower-fat, higher-carbohydrate diet.
Researchers file First Amendment challenge to NIH grant screening
Lawsuit argues that Trump policy of purging politically sensitive terms from research projects violates free speech
Smelling chocolate helped men complete more reps without feeling more tired
Simply smelling chocolate helped men complete more leg extension repetitions without making the workout feel harder, with dark chocolate producing the strongest effect. The researchers think familiar food aromas may influence appetite and motivation by making the brain anticipate eating.
Scientists discover a major brain shift between ages 50 and 75
Scientists have uncovered sweeping changes in how the human brain controls and organizes its genome beginning in midlife, offering new clues to why aging sharply increases the risk of Alzheimer’s and other neurodegenerative diseases. One of the biggest shifts occurred between about ages 50 and 75, when many of the brain’s original immune cells declined and were replaced by cells with more inflammatory characteristics. Researchers also found weakening of cells that help maintain the blood-brain barrier, along with widespread deterioration in the genome’s three-dimensional organization.
Why AI agents invent their own language if you let them chat
“Weird terms” are a natural—but disturbing—byproduct of agent swarms, researchers find