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A surprising discovery could help aging muscles repair themselves
Scientists have discovered a compound that transforms a natural muscle-repair protein into a more powerful version dubbed "Super HGF," more than doubling its ability to bind to a key receptor while protecting it from age-related chemical damage. The breakthrough, supported by early mouse experiments, could eventually help combat muscle loss and preserve strength as people age.
Scientists may have finally explained why our brains and bodies are cross-wired
Scientists propose that the brain’s mysterious cross-wiring, which connects each hemisphere to the opposite side of the body, may have originated more than 500 million years ago in the visual systems of ancient fish. Rather than evolving for a specific advantage, this unusual arrangement may simply be a legacy of evolution building new brain circuits on an ancient foundation.
Permanent daylight saving time has a dark side, scientists warn
A new study warns that permanent daylight saving time could force American children to make at least 2 billion additional school commutes in darkness, potentially increasing safety risks and disrupting their biological clocks. Researchers found that fatal crashes involving school-aged pedestrians were roughly twice as likely during dark mornings as after sunrise.
U.S. archaeology faces ‘apocalyptic’ threat
Congress and the White House are moving to weaken key law that requires preproject reviews
Physiological APP processing is required for synaptic plasticity and cognition
While the accumulation of Aβ peptides, derived by proteolytic cleavage from the amyloid precursor protein APP, constitutes a hallmark of Alzheimer's disease, the question of whether endogenous, physiological APP processing serves an essential role for normal brain function(s) has remained elusive. Here, we modified the mouse APP locus to delete the endogenous α- and β-secretase sites (APP residues S592-G621) while preserving the transmembrane topology and the APP C-terminus. These novel knockin...
APOE2 attenuates APOE4-associated amyloid pathology and related toxicity in a mouse model of Alzheimer's disease
The apolipoprotein E (APOE) gene is the strongest genetic risk factor for Alzheimer's disease (AD), influencing amyloid-β (Aβ) aggregation, clearance, and glial function. While APOE4 promotes Aβ pathology and APOE2 is protective, how these opposing alleles interact in the heterozygous APOE2/4 state remains unknown. Here, using littermate-controlled heterozygous APOE mice (APOE2/3, APOE3/4, and APOE2/4) alongside APOE3/3 controls crossed with 5xFAD mice, we show that APOE3/4 mice exhibit...
Parkinson's: beyond the brain
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Language modeling screens Parkinson's disease with self-reported questionnaires
Parkinson's disease (PD) is a growing public health challenge as populations age. Current diagnosis relies on motor symptoms and invasive procedures, making early detection difficult. Here we present Quest2Dx, a generalized artificial intelligence model that analyzes health questionnaires to enable low-cost, non-invasive PD screening. Conventional models are built for each questionnaire, and missing responses degrade their performance. Quest2Dx uses language modeling to encode the meaning of...
Screening for Parkinson's disease across questionnaires using language models
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Progress accelerates in Parkinson's treatments
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Six highlights from Parkinson's disease research
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Replacing the neurons that Parkinson's destroys
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Could chemicals contribute to Parkinson's?
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How the brain protects itself from Parkinson's disease
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Fine-tuning brain stimulation to fight Parkinson's disease
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How a once-controversial idea is advancing understanding of Parkinson's disease
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Clearing the way for a transformative stem-cell treatment for Parkinson's disease
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Bifidobacterium animalis subsp. lactis BL-99 ameliorates age-related intestinal hypomotility in older adults: a randomized controlled trial
The decay of smooth muscle contractility is a major trigger of aging-related intestinal hypomotility, which imposes a substantial healthcare burden. Despite this, effective targeted therapy for this condition remains unavailable. Here, we identified the probiotic Bifidobacterium animalis subsp. lactis BL-99 as a microbiota modulator that restores gut motility through the bile acid (BA)-mediated rescue of smooth muscle contractile function. In a randomized, double-blind clinical trial...
Lung environment in healthy old age shapes the phenotype and CCR2-mediated recruitment of a subset of apoptotic, high-turnover alveolar macrophages
Immune system changes with healthy aging lead to chronic systemic inflammation termed inflammaging, contributing to age-related pathologies. Alveolar macrophages (AMs) maintain lung homeostasis and health. The impact of inflammaging on AM populations requires further definition. Herein, we examined the effect of healthy old age on the phenotype and ontogeny of AMs from mice, non-human primates and humans. We identify three AM subpopulations in old age, including a CD11c^(+)CD11b^(+) population...
Neonatal overfeeding accelerates age-related sarcopenia and metabolic disorders through lifelong gut mucosa and microbiota programming in mice
Early-life nutrition shapes lifelong health, yet the long-term consequences of childhood overnutrition, particularly on musculoskeletal aging, remain unclear. Here, we show that neonatal overfeeding acts as a developmental insult that accelerates age-related sarcopenia in both sexes. Using different mouse models, early overnutrition shortens lifespan and exacerbates late-life muscle atrophy, accompanied by metabolic dysfunction. Mechanistically, neonatal overfeeding disrupts goblet cell...