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Gilead is criticized for lack of affordable access to lenacapavir in Latin America

Black holes can form spiraling pairs in three different ways, the gravitational waves from hundreds of collisions suggest

White House report aims to shake up a “calcified system,” but researchers warn it could do more harm than good

A major review found that exercise produces only small average improvements in hip osteoarthritis pain and physical function. It may still help some people, but researchers warn that current evidence is too limited to know which exercises work best.

A single 30-minute sauna session may briefly put the immune system on higher alert. Finnish researchers found that sauna heat, paired with a short cold shower, increased every type of white blood cell circulating in the bloodstream, including key infection fighters such as neutrophils and lymphocytes.

Dreams are not random mental noise. A large study of more than 3,700 dream and waking reports found that what we experience during sleep is shaped by both our personalities and the world around us. Rather than simply replaying daily events, the dreaming brain mixes memories, emotions, imagined possibilities, and familiar settings into vivid new scenarios.

Unsweetened sparkling water may offer a tooth-friendlier alternative to sugary soda, according to a small preliminary study tracking how different drinks change mouth acidity. Soda caused the strongest and longest drop in salivary pH, while sparkling water produced only a temporary decline before saliva restored normal conditions. Importantly, acidity remained above the level associated with enamel damage.

Population declines led to spike in spinal deformities and rare tumors, fossil study suggests

Artful dodging allow males to elude females trying to eat them, slow-motion videos show

Wogonin, a naturally occurring flavonoid derived from Scutellaria species and widely used in traditional East Asian medicine for its anti-inflammatory and antioxidant effects. Although wogonin has demonstrated efficacy against oxidative stress and inflammation, its mechanistic role in Parkinson's disease (PD) remains incompletely understood. The present study investigated the neuroprotective potential of wogonin in a rotenone-induced mice model of PD, with particular emphasis on modulation of...

CONCLUSIONS: The findings indicate that the cognitive effects of multi-session resistance exercise are domain-specific rather than uniform across cognitive abilities. Resistance exercise appears particularly promising for supporting cognitive processes involving executive control, working memory, and rapid information processing. However, interpretation should remain cautious given heterogeneity across studies, limited evidence in some domains, and variation in intervention duration, intensity,...

CONCLUSION: A putative epigenetic relation was found between miR-124 levels and their association with SIRT1. The investigated biomarkers of aging are associated with serum concentration of 25(OH) vitamin D in a middle-aged vitamin D-deficient rat model, which supports the need for mechanistic investigation in future studies.

Estrogen receptor-positive (ER^(+)) breast cancer is the most common subtype of breast cancer and is an age-related disease. How systemic and tumor microenvironment hormone signaling intersects with chronic inflammation and how this shapes aging-associated tumor biology remain incompletely understood. Here, using an aged rat model of ER^(+) tumors, we identify age-associated differences in tumor development and immune features. In parallel, analysis of samples from patients with ER^(+)/HER2^(-)...

Single-cell foundation models such as scGPT and Geneformer are large neural networks trained on human single-cell RNA-seq data. They were never shown chronological age during training. Do their internal representations nevertheless encode aging biology in a way that can be interpreted, and how should we test whether an apparent aging signal is real biology rather than an artifact of which donors and cell types happened to be sampled?. We applied a nine-step evaluation pipeline to two foundation...