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Superconducting cables connect quantum bits on different chips, but improvements are still needed

Study adds to mounting evidence that traumatic experiences can negatively impact health years—or even decades—later

As AI firms churn out math breakthroughs, researchers question use of Lean software as proof checker

Why do some people stay mentally sharp even when their brains show signs of Alzheimer’s disease? Scientists in the Netherlands may have uncovered an important clue hidden in a rare group of immature brain cells. Researchers discovered that these cells remain present even in people over 80, but their behavior differs dramatically between those who develop dementia and those who remain cognitively healthy.

Mayo Clinic scientists have uncovered surprising new insights into “zombie cells,” aging cells that linger in the body and contribute to inflammation and disease. Seven studies reveal why these cells are harmful and identify new strategies for targeting them, including a natural compound found in tomatoes. In aging mice, experimental treatments reduced inflammation and improved physical and brain health. The findings could open the door to therapies that combat some of the biological processes behind aging.

A surprisingly simple exercise routine could help lower blood pressure without requiring daily workouts or expensive equipment. In a study of 100 adults, researchers found that wall squats performed just once or twice a week helped maintain significant reductions in systolic blood pressure over the short term.

Scientists have identified a hidden cause of inflammatory bowel disease: antibodies that disable the immune system’s natural ability to control inflammation, potentially explaining severe illness in thousands of patients. The breakthrough also solves a 30-year genetic mystery and could pave the way for more precise diagnoses and targeted treatments.

Regular exercise does more than strengthen the heart. New research reveals that it actually reshapes the nerves controlling how the heart functions, and the changes are surprisingly different on the left and right sides of the body.

Aging, neuroinflammation and metabolic dysfunction are tightly intertwined in Alzheimer's disease (AD), but how transient pathological signals become persistent cellular states remains poorly understood. Histone post-translational modifications (PTMs) provide a dynamic interface between extracellular stimuli, cellular metabolism and chromatin state. This Review examines how canonical histone modifications and emerging metabolite-derived acylations regulate inflammatory and stress-responsive...

Aging, neuroinflammation and metabolic dysfunction are tightly intertwined in Alzheimer's disease (AD), but how transient pathological signals become persistent cellular states remains poorly understood. Histone post-translational modifications (PTMs) provide a dynamic interface between extracellular stimuli, cellular metabolism and chromatin state. This Review examines how canonical histone modifications and emerging metabolite-derived acylations regulate inflammatory and stress-responsive...

High-quality reference genomes are essential for comparative and functional genomics yet remain unavailable for many emerging model organisms. Here, we report OctDeg2.0, a chromosome-level genome assembly and annotation of the degu (Octodon degus), generated using PacBio HiFi long-read sequencing and Hi-C scaffolding from a single male individual. Octodon degus is of growing interest as a natural animal model for aging and Alzheimer's disease research. The 3.4 billion base-pair assembly...

Resting-state electroencephalography is increasingly proposed as a scalable marker of healthy brain ageing, yet its interpretability depends on distinguishing stable individual characteristics from condition-dependent measurement effects. This secondary analysis of an open lifespan dataset examined periodic alpha activity, alpha-peak detectability, aperiodic spectral structure, short-term repeatability, and longitudinal change under eyes-open and eyes-closed conditions before and after an...

High-quality reference genomes are essential for comparative and functional genomics yet remain unavailable for many emerging model organisms. Here, we report OctDeg2.0, a chromosome-level genome assembly and annotation of the degu (Octodon degus), generated using PacBio HiFi long-read sequencing and Hi-C scaffolding from a single male individual. Octodon degus is of growing interest as a natural animal model for aging and Alzheimer's disease research. The 3.4 billion base-pair assembly...