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Breakthroughs in genetically altering cephalopods pave way for new studies of perception, brain evolution, and more

New underground labs are being built as war rages on

Scientists found that immune cells contributing to Alzheimer’s-related brain damage may be activated in lymph nodes outside the brain before traveling into the nervous system. Blocking this pathway in mice dramatically reduced neurodegeneration and preserved cognitive abilities, pointing to a potentially more accessible treatment target.

Luciana Gatti, who studies carbon uptake in the Amazon, aims to join Brazil’s lower house in this weekend’s elections

The AI-based assessment, which wasn’t explicitly described in the funding call, has raised privacy and fairness concerns

A large health-record analysis found that glucosamine use was associated with a 25% higher likelihood of mild cognitive impairment progressing to dementia. Lab experiments suggest the popular joint supplement may intensify an abnormal sugar-tagging process in the Alzheimer’s brain, although researchers say clinical trials are needed to determine whether it actually causes harm.

Direct oral anticoagulants cut the risk of serious clinical events by 69% in atrial fibrillation patients with an intermediate risk of stroke, according to the randomized SINGLE-AF trial. The benefit was driven mainly by fewer ischemic strokes, with no increase in major bleeding.

A single dose of an experimental CRISPR therapy cut LDL cholesterol and triglycerides by about half in patients with difficult-to-treat lipid disorders. The reductions were still present one year later, with the highest dose lowering LDL by 52.5% and triglycerides by 47.8%.

Pain and fatigue in rheumatoid arthritis can persist even after inflammation improves, with depression, poor sleep, obesity, smoking, and chronic pain potentially helping sustain symptoms. Researchers say identifying these hidden drivers could prevent unnecessary medication changes and lead to more personalized treatment.

Nematode growth medium (NGM) has been the standard culture medium for Caenorhabditis elegans (C. elegans) for over five decades and contains peptone to support proliferation of the bacterial food source, Escherichia coli OP50. However, the increasing use of paraformaldehyde (PFA)-killed OP50 in studies of metabolism, aging, and host-microbe interactions raise the question of whether peptone remains necessary once bacterial proliferation has been eliminated. Here, we systematically compared...

This study examined the impact of nine years of continued cycling exercise on physiological function in older exercisers, viewed as a model of inherent biological aging free from the negative effects of inactivity. A range of cardiorespiratory indices were measured, with peak oxygen consumption (V̇O(2peak)) as the primary outcome. Of an original 125 cyclists first assessed in 2012-2013, 82 (53 males, 29 females) returned 9 years later (aged 64-86 years at follow up). V̇O(2peak) declined by 19.7%...

Eccentric exercise is widely used in rehabilitation protocols for older adults. However, the age-related behavior of the muscle-tendon unit (MTU) during eccentric actions remains incompletely understood, especially regarding muscle-tendon decoupling and its influence on fascicle dynamics and force production. Better characterizing these mechanisms would help optimize the design of rehabilitation protocols in older individuals. This study aimed to investigate age-related differences, while...

DNA storage is a promising solution to data explosion due to its high density and longevity. However, existing coding methods struggle to efficiently avoid error-prone sequences while retaining usable ones, leading to low density and high copy numbers. Here we show Siyuan Code, a DNA storage codec that achieves theoretically optimal density. Our method maps binary data to nearly all suitable low-error sequences in a one-to-one manner, using our data structure to catalog and avoid error-prone...