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One-fifth of data sets intended to support replication breached privacy standards, study finds

Nighttime light exposure was linked to thicker, stiffer heart chambers and early signs of reduced heart function in a study of more than 11,000 people. The findings suggest that keeping bedrooms darker could be an overlooked strategy for protecting the heart.

A remarkably detailed study of Maria Branyas, who lived past 117, reveals that extreme longevity may involve both intense aging and powerful biological protection at the same time. Researchers found signs of advanced aging, but also low inflammation, beneficial gut bacteria, protective genetic features, and a biological age younger than her chronological age. Because she avoided major disease, the study offered a rare look at aging itself rather than the illnesses that often accompany it.

Researchers have shown for the first time that human heart muscle cells can regrow after a heart attack. The finding overturns the idea that damaged areas of the heart are completely incapable of regeneration. Scientists now hope to identify ways to dramatically boost this natural repair process, potentially opening a new path toward treatments for heart failure.

Genesis Mission partnership between national labs and AI startup builds new model to automate large-scale science

Eating only between noon and 8 p.m. improved blood sugar control in a small study of adults with Type 1 diabetes and obesity, while avoiding an increase in serious complications. The promising findings offer the first evidence that time restricted eating could become another tool for managing the condition.

Science, Ahead of Print.

UCLA researchers developed ready-made cancer-fighting T cells from cord blood stem cells that can attack solid tumors through two separate detection systems. In mice, a single dose controlled cancer and extended survival while avoiding a dangerous complication associated with donor-derived T-cell therapies.

Ecological theories predict a fundamental trade-off between fast growth and the probability of achieving longevity, with far-reaching consequences for ecosystem resilience and carbon residence time. Tree-ring studies have revealed a globally consistent negative relationship between growth rate and lifespan, yet comparable large-scale evidence for such trade-offs beyond trees remains scarce, largely due to methodological limitations. Here, we exploit annual growth rings formed by secondary...

Certain forms of mitochondrial impairment confer longevity, while disease-associated mitochondrial dysfunction triggers pathogenesis. The adaptive pathways that distinguish benefit from pathology remain unclear. Here we reveal that longevity induced by mitochondrial Complex I/nuo-6 mutation in C. elegans is dependent on the endoplasmic reticulum (ER) Ca^(2+) channel, InsP3R. To explain this connection, we test multiple candidate links between Ca^(2+) and mitochondrial homeostasis previously...

Alzheimer's disease (AD) is a progressive neurodegenerative disorder whose global prevalence is rapidly increasing, highlighting the urgent need to identify modifiable risk factors. Chronic alcohol consumption has emerged as one such significant factor contributing to the risk and progression of AD. Importantly, alcohol metabolism impacts cellular acetylation pathways, creating an environment that promotes protein dysregulation and disrupts cellular functions. Among these alterations, tau...

Blood phosphorylated tau at threonine 217 (p-tau217) has shown considerable potential for the diagnosis of Alzheimer's disease (AD). For successful implementation in clinical practice, its applicability must be established across representative populations and settings. In this systematic review, we aimed to characterize participants included in p-tau217 research in AD, focusing on study setting, and sociodemographic and clinical features relevant to biomarker interpretation, and to assess how...

CONCLUSIONS AND IMPLICATIONS: Age and gender are critical modifiers of functional recovery after hip fracture. The vulnerability of 70 to 79 year olds and the increasing ADL disability during recovery of the oldest-old underscore the need for age-specific rehabilitation strategies in aging populations like China.