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Structural brain indicators of cognitive performance in middle and late adulthood: The Human Connectome Project in Aging/Aging Adult Brain Connectome cohort
Although cortical thinning and atrophy are well documented in aging and neurodegenerative disease, the cortical structural features associated with preserved or superior cognition across typical adulthood remain incompletely characterized. We examined associations between cortical thickness and cognitive performance in a large, typically aging cohort and tested whether they vary by age and cognitive domain. We analyzed cross-sectional data from cognitively healthy adults in the Human Connectome...
Development and validation of a machine learning-based claims frailty index for predicting mortality, disability, and healthcare utilization in middle-aged and older adults
CONCLUSIONS: A machine learning-derived CFI integrating diagnoses, medications, and procedures demonstrated robust prediction of mortality and other adverse outcomes, supporting its incremental value in population-based frailty assessment.
A reproducible pipeline for processing commercial wearable step-count data in aging cohorts: Application and evaluation in the STRRIDE-PD reunion study
Wearable devices offer the ability to objectively characterize free-living physical activity; however, raw step-count data generated by commercial devices require systematic processing before they can support rigorous inference. We describe a transparent, reproducible standard operating procedure (SOP) for transforming epoch-level step-count data from commercial Garmin devices into participant-level analytic variables and demonstrate its application in the STRRIDE-PD Reunion study: a long-term...
Functional brain network connectivity patterns associated with midlife metabolic syndrome and cognitive vulnerabilities
CONCLUSION: Midlife MetS was associated with modest reductions in within-network DMN connectivity, with abdominal obesity and low HDL cholesterol as the primary contributing MetS components. Reduced DMN connectivity was associated with poorer verbal fluency performance. These findings suggest that subtle differences in higher-order functional brain network organization associated with metabolic syndrome can be detected during midlife and are related to cognitive functioning, highlighting the...
beta-Nicotinamide Mononucleotide Inhibits Cellular Senescence in Mouse C2C12 Skeletal Muscle Cells
β-Nicotinamide mononucleotide (NMN), as the precursor of nicotinamide adenine dinucleotide (NAD^(+)), has remarkable therapeutic potential in aging-associated diseases. Skeletal muscle exhibits not only reduced mass but also impaired strength and function during aging. However, the protective effects of NMN against skeletal muscle cell senescence remain to be fully elucidated. In this study, we used D-galactose (D-gal) to establish a senescence model in C2C12 cells. Our results demonstrate that...
The Role of EVs in the Aging Hematopoietic System
Extracellular vesicles (EVs) are membrane-enclosed nanoparticles that mediate intercellular communication by transferring proteins, nucleic acids, and lipids. Within the hematopoietic system, EVs orchestrate critical signaling between bone marrow (BM) niche cells and hematopoietic stem and progenitor cells (HSPCs) to regulate quiescence, proliferation, and lineage commitment. During aging, senescence and telomere attrition drive a profound remodeling of EV biogenesis and cargo. Aged EVs,...
Mapping the Landscape of AgeTech Standards and Guidelines: A Gray Literature Review
CONCLUSIONS: Although AgeTech standardization is advancing, critical gaps remain. Limited attention to safety, security, privacy, and digital economy and community inclusion raises concerns for trust, equity, and sustainable adoption. Addressing these gaps through targeted and coordinated standardization efforts is essential to support inclusive, trustworthy, and scalable AgeTech solutions in the context of rapid global population aging.
Daily briefing: Will AI really be the death of us all?
A cross-species single-cell kidney epigenome atlas reveals epithelial-dominant aging-like states in disease
Multi-modality profiling identifies <i>Neisseria flavescens</i> as a central geroprotective oral commensal in humans
Publisher Correction: Physical activity delays ovarian aging in part through adiponectin-related signaling pathways
GLP-1 drugs fail to help some people lose weight — scientists are on a quest for answers
AlphaFold ‘goes viral’: database adds protein complexes of common viruses
AI agent hacks government website for first time: why this breach matters
AI system helps lab devices ‘talk’ with each other — streamlining research
Youthful fans of YouTube sports videos stick to the sofa
Bumblebees don’t mind a little plastic in their honeypots
Verification makes discovery matter
Science, Ahead of Print.
In-cell structures visualize human pre-ribosome assembly in the nucleolus
Science, Ahead of Print.
Stereodivergent telomerization of linear functionalized dienes with amines
Science, Ahead of Print.