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Deletion of SPI1 in microglia exacerbates amyloid pathology by impairing microglial response in Alzheimer's disease models
Recent human genetic studies have highlighted the potential role of microglial genes and their regulatory functions in the pathogenesis of Alzheimer's disease (AD). The transcription factor PU.1 (encoded by SPI1) is expressed mainly in microglia in the central nervous system and has been reported to be a genetic risk factor for AD. However, the role of microglial SPI1 in AD etiology is still poorly understood. Here, we demonstrate that the selective deletion of Spi1 in microglia exacerbates...
Identifying maximally informative signal-aware representations of single-cell data using the information bottleneck
Rapid advancements in single-cell RNA sequencing (scRNA-seq) technologies revealed the richness of myriad attributes encompassing cell identity. However, the complexity of the data hinders tasks focusing on a specific biological signal. To address this challenge, we introduce bioIB, a framework based on the information bottleneck method, designed to extract an interpretable compressed representation of scRNA-seq data, optimally informative with respect to a specific biological signal, such as...
Healthy ageing and quality of life: exploring factors associated with quality of life among older adults in Tabuk, Saudi Arabia
No abstract
A Buffering Role of Perceived Social Support and Resilience between Caregiver Burden and Perceived Stress among Informal Caregivers of Dementia Elderly Patients
No abstract
A phenomenological study of fatigue experience in community-dwelling older adults
No abstract
Comment on: Effectiveness of a Telephonic Aging Brain Care Model for Medicaid Home and Community Services for Dementia Patients and Their Caregivers
No abstract
Massive budget cuts for US science proposed again by Trump administration
Neuronal APOE4-induced early hippocampal network hyperexcitability in Alzheimer’s disease pathogenesis
The case for space as a model of accelerated aging
U.S. Forest Service unveils extensive closures of research facilities
Cost-cutting move is expected to cause resignations and turmoil
Slasher sequel: Trump again proposes major cuts to U.S. science spending
Science advocates urge Congress to reject 2027 budget plan
History and mystery surround NASA’s 2028 nuclear Mars mission
Fission-powered space flight, a 60-year dream, would supercharge outer Solar System exploration
China now tops the U.S. in R&D spending by one key measure
China reached long expected milestone in 2024
Urogenital dysfunction in neurological diseases
Neural damage at any level of the neuraxis can lead to urogenital dysfunction, involving the lower urinary tract (LUT) and/or the sexual organs. The LUT consists of the bladder and the urethra (plus the prostate in males); LUT dysfunction can manifest as an underactive bladder, leading to urinary retention, or as an overactive bladder, leading to urinary incontinence. Manifestations of sexual dysfunction include loss of libido and dysfunction of erection, ejaculation and orgasm. In this Review,...
Dialling up the circadian clock to target ageing
No abstract
ss-adrenergic-like signalling engages CrebB in Drosophila gut to promote female longevity
Adrenergic signalling is heavily implicated in human age-related disease and yet the potential for this neuroendocrine signalling pathway to modulate ageing has received little attention. Here, we use Drosophila melanogaster to test if adrenergic-like signalling can promote longevity by manipulating tyramine (TA) or octopamine (OA), the invertebrate equivalents of adrenergic hormones. Increased neuronal synthesis of TA boosts health and longevity in both sexes, whereas OA is marginally...
Scientists brace for expansion of Alzheimer's blood tests
Growing use of p-tau217 raises concerns about testing in healthy people.
Harnessing viral strategies to reverse cognitive dysfunction through the integrated stress response
The integrated stress response (ISR) is essential for cellular homeostasis and cognitive function. We investigated how persistent ISR activation affects cognitive performance by studying the PPP1R15B^(R658C) genetic variant associated with intellectual disability. To model this condition, we generated a mouse line with the pathogenic allele inserted. This variant destabilized the PPP1R15B•PP1 phosphatase complex, causing persistent ISR activation, impaired protein synthesis, and long-term memory...
Siah-1 is Critical for Hypoxia-Induced Lifespan Extension in Caenorhabditis elegans by Regulating the Expression of SKN-1
CONCLUSION: The present study identifies Siah-1 as a novel mediator linking hypoxic signaling to SKN-1-dependent transcriptional programs, providing insights into conserved mechanisms of stress adaptation and aging. This work underscores the importance of ubiquitin-mediated regulatory nodes in coordinating longevity pathways under environmental stressors.
Harnessing viral strategies to reverse cognitive dysfunction through the integrated stress response
The integrated stress response (ISR) is essential for cellular homeostasis and cognitive function. We investigated how persistent ISR activation affects cognitive performance by studying the PPP1R15B^(R658C) genetic variant associated with intellectual disability. To model this condition, we generated a mouse line with the pathogenic allele inserted. This variant destabilized the PPP1R15B•PP1 phosphatase complex, causing persistent ISR activation, impaired protein synthesis, and long-term memory...