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CONCLUSIONS: Involving older adults in digital-health studies that draw on domestic energy data must account for the broader social and economic environment. Financial strain, digital fraud, and pandemic-related mistrust all influenced disengagement. Early community involvement, co-design, and opportunities to discuss or engage directly with the technology may support more confident and informed participation in future research.

CONCLUSIONS: Co-occurrence of pain with depression or/and sleep complaints is a common and potentially modifiable contribution to poor cognition. Our findings highlight the need for targeted interventions addressing co-occurring conditions to mitigate cognitive decline among older Mexican Americans. Educational attainment modified these associations, with higher schooling attenuating baseline cognitive differences across symptom classes, consistent with a passive cognitive reserve framework, and...

CONCLUSION: Higher levels of physical activity are independently associated with better multidimensional healthy ageing and more positive perspectives on ageing among older adults with chronic conditions and functional vulnerability. These findings highlight physical activity as a key modifiable factor for promoting healthy ageing and support the integration of feasible physical activity interventions into health-care and rehabilitation services for older adults, particularly in rapidly ageing...

CONCLUSION: There is a relationship between unhealthy lifestyle, health literacy, and frailty in older adults. Health literacy may serve as an apparent protective factor against frailty. An unhealthy lifestyle could exacerbate frailty. Therefore, healthcare providers should focus on enhancing health literacy and a healthy lifestyle to prevent frailty in this population.

CONCLUSION: The findings support a psycho-social perspective on healthy aging. Aging attitudes were generally linked to better health, while digital inclusion showed mixed associations, suggesting that digital engagement can be helpful when it is meaningful and supported, but burdensome when it exceeds older adults' skills or needs. Policies and interventions should therefore go beyond expanding digital access and strengthen digital competence, age-friendly digital environments, and positive...

Protein homeostasis is essential for maintaining normal cellular function. However, protein homeostasis efficiency declines with age, leading to the accumulation of aberrant protein structures associated with neurodegenerative diseases such as Parkinson's disease (PD). PD is characterized by the aggregation of alpha-synuclein (αSyn) into cytoplasmic inclusions. This process is accompanied by elevated phosphorylation at serine 129 (S129). The accumulation of αSyn into aggregates and their...

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Tauopathies are neurodegenerative diseases characterized by the accumulation of misfolded tau protein and include Alzheimer's disease (AD) and related dementia disorders. Identifying new strategies to treat tauopathy remains an important gap in the field. Using forward and reverse genetic approaches in C. elegans, we identified smrd-1, the C. elegans homolog of SMARCAD1, as a potent modifier of tauopathy phenotypes in a transgenic model of tauopathy. Loss of smrd-1 function rescues...

CONCLUSION: Our findings suggest a significant association between a reduced number of functional teeth and low HGS in older adults. While these results highlight the potential relevance of oral health to physical capacity, further longitudinal studies are required to clarify the temporal relationship and to determine whether preserving functional dentition may be associated with better physical function and a lower risk of subsequent functional decline.

CONCLUSIONS: This study uncovers the multi-layered genetic and molecular architecture underlying ovarian aging. The identified molecular traits provide promising candidates for functional studies and suggest new avenues for developing therapies aimed at preserving ovarian function and preventing age-related decline.

A newly identified protein called GPNMB may play a major role in helping Parkinson’s disease spread through the brain. Researchers discovered that immune cells release the protein in response to damaged neurons, creating a vicious cycle that speeds up brain cell degeneration. In early experiments, antibodies that blocked GPNMB stopped the toxic process from spreading between cells.

Science, Ahead of Print.

A new brain imaging study has found no evidence of widespread brain inflammation in patients suffering from prolonged symptoms after COVID-19 infection. Instead, the most severe long COVID symptoms were associated with increased brain activity in regions involved in mood and emotion.

A surprising new approach to depression treatment is showing early promise — not by targeting brain chemicals, but by calming the immune system. In a small clinical trial, researchers found that an anti-inflammatory drug normally used for rheumatoid arthritis appeared to ease symptoms in people with hard-to-treat depression, while also reducing fatigue and anxiety and improving quality of life.