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Towards intelligent and miniaturized drug delivery devices
Functional hierarchy of the human neocortex across the lifespan
Exposed phosphatidylserine is an inhibitory molecule in T cell exhaustion
Ectopic NMDAR expression in cancer unmasks germline-encoded autoimmunity
Dominant clones leverage developmental epigenomic states to drive ependymoma
Genomic history of early dogs in Europe
Can China keep up its extraordinary research growth?
Why insects aren't huge: a new challenge to a decades-old idea
Retraction Note: Multisensory learning binds neurons into a cross-modal memory engram
Sock. Something. Um.
The surprising science behind red-light therapy — and how it really works
‘Continuity over novelty’: why environmental science needs to rethink its focus
Major conference catches illicit AI use — and rejects hundreds of papers
NASA revives next-generation flagship Earth-observing missions
“Falcon” and “Eagle” will monitor changing clouds and map critical minerals
Trump’s new science panel is stuffed with high-tech billionaires
The PCAST roster contains few academics and women
Dueling AI agents could reveal keys to restoring consciousness
A new study probes consciousness with models that simulate and classify brain activity. A neuroscientist behind the work explains its ambitions
Neurobiological links between Alzheimer's disease and reward system dysfunction
Alzheimer's disease (AD) is a highly prevalent progressive neurodegenerative disorder with unclear etiology, complex symptoms, and limited treatment options. Early pathological processes in AD emerge long before the onset of overt cognitive and motor symptoms and involve the accumulation of amyloid-β oligomers and neurofibrillary tangles, accompanied by neuroinflammation and neuronal loss. Importantly, the brain reward system comprises cortical and subcortical structures that share neurochemical...
Pan-neurodegeneration proteomics reveals disease subtypes and molecular signatures
Neurodegenerative diseases (NDs) pose clinical challenges due to their complexity and molecular heterogeneity. Here, we present a pan-neurodegeneration atlas (PanNDA) from multilayer, deep proteomic analysis of 2,279 human brain samples spanning 6 major NDs: Alzheimer's disease (AD), Lewy body dementia (LBD), frontotemporal lobar degeneration with TDP-43 pathology, progressive supranuclear palsy with tau pathology, vascular dementia, and Parkinson's disease. PanNDA integrates data from whole...
Amyloid precursor protein derivatives differentially alter the microRNA cargo of astrocyte-derived extracellular vesicles
Alterations to the protein and microRNA cargo of extracellular vesicles (EVs) occur in Alzheimer's disease (AD) and may contribute to disease progression. We previously showed that ingestion of amyloid-beta (Aβ) by both murine and human astrocytes leads to alterations to the protein cargo of EVs that induce significant neuronal impairment and apoptosis. Here, we hypothesised that pathological changes to the microRNA cargo of astrocyte-derived EVs (ADEVs) would also occur following exposure of...
Early-onset axonal pathology and β-amyloidosis in human brains with hematological malignances and cardiovascular diseases
β-Amyloid (Aβ) and tau pathologies are hallmark lesions of Alzheimer's disease (AD) and they develop in human brain following differential spatiotemporal trajectories. Accordingly, young/adult-onset tau-independent β-amyloidosis is rare. We encountered four such cases among 397 banked brains, with the donors died of hematological malignances (blood cancers) or cardiovascular diseases. To explore the pathological implication, we examined 17 brains (10-87 year-old, y) from blood cancer patients...