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Inactivation of V-ATPase induces autophagy and ectopic Notch activation to promote intestinal stem cell differentiation in adult <em>drosophila</em> midgut
The self-renewal and differentiation of stem cells are tightly controlled to maintain tissue homeostasis. Failure in stem cell maintenance results in stem cell depletion and precocious aging. However, how stem cells are maintained still remains not fully understood. Here, through a large-scale RNAi screen for maintenance and proliferation of adult Drosophila intestinal stem cells (ISCs), we identify several subunits of V-ATPase including Vha68-2/ATP6V1A, required for ISC proliferation,...
Targeting chaperone-mediated autophagy by nutritional interventions mitigates age-related cardiac fibrosis and diastolic dysfunction
Cardiac fibrosis, a major pathological hallmark of aging that leads to heart failure, is characterized by excessive collagen deposition. Our knowledge of what sustains collagen synthesis in the aging heart is still very preliminary. Here, we uncover a central role for chaperone-mediated autophagy (CMA), a selective lysosomal degradation pathway, in this process. We demonstrate that CMA is suppressed in the aging heart, which promotes collagen overproduction in fibroblasts, whereas enhancing CMA...
Daily briefing: ‘Raygun’ AI can shrink or supersize proteins
The chemotherapy-induced senescence-associated secretome promotes cell detachment and metastatic dissemination through metabolic reprogramming
Agentic AI for scaling diagnosis and care in neurodegenerative disease
Plasma proteomics framework predicts metabolic dysfunction-associated steatotic liver disease up to 16 years before onset
Ultra-early proteomic signatures predict MASLD up to 16 years ahead
Fires in Europe are breaking records: here’s what the future holds
Author Correction: Sleep chart of biological ageing clocks in middle and late life
Somatic mutations reveal the ontogeny of microglia in human aging
How I use statistics and my law degree to fight human-rights abuses
Demand for lithium is surging: here’s how to make mining more sustainable
Job insecurity is chipping away at me and my cohort. Is it us, or the state of the economy?
Recovering signatures of archaic hominin introgression using ancestral recombination graphs
Science, Ahead of Print.
EXCLUSIVE: Congo’s Ebola epidemic started at least 4 months before it was detected
A remote mining town gripped by fear saw hundreds of suspected cases before the government declared an outbreak, report says
High-speed orcas are blowing sunfish to smithereens
Never-before-seen behavior may represent the giant cetaceans playing with their food, ecologists say
Ancient DNA confirms historical accounts of how smallpox got to the Americas
“Landmark” paper finds disease originated with European contact
Daily multivitamin may help older adults stay independent
Taking a daily multivitamin may help older adults preserve the strength and stamina needed for everyday activities. After three years, users reported better functional health than those taking a placebo, although the preliminary findings still require peer review.
Scientists find a simple way to stop cavities without drilling
A liquid brushed onto cavities in seconds may spare many young children from pain, infection, and surgery. A major U.S. trial found that silver diamine fluoride stopped decay in more than half of treated baby teeth. The treatment requires no drilling, shots, or sedation, although it does permanently darken the decayed area.
Your gut may help your brain decide what to remember
Signals traveling from the gut to the brain may help turn meals into lasting memories. Rats showed stronger memory activity after consuming nutritious foods, but not after drinking sweet liquids with little or no nutritional value. Blocking the vagus nerve erased this effect and made it harder for the animals to remember where food had been located. Over time, diets high in fat and sugar also weakened this memory system.