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University punishes Étienne Klein after investigation shows he plagiarized part of his Ph.D. thesis

Bringing blood sugar levels back to normal may dramatically reduce the danger posed by prediabetes. Researchers found that people who reversed prediabetes cut their risk of cardiovascular death or hospitalization for heart failure by 58% and lowered their chances of major heart problems such as heart attacks and strokes by 42%. The benefits lasted for decades and were seen across large long-term studies in both the U.S. and China.

CONCLUSIONS: These findings highlight severe frailty as a late high-risk state and may inform age- and sex-specific frailty risk stratification and care planning.

Increasing experimental and clinical evidence indicates activation of cellular programs resembling senescence and senescence-associated secretory phenotype signaling after stroke. However, a central challenge is definitional: in injured brain tissue, many senescence-associated features overlap with acute stress responses, transient cell-cycle perturbations, and reactive glial or vascular programs, complicating interpretation across models, time points, and cell types. Here, we synthesize the...

Aging is accompanied by the accumulation of senescent cells and chronic low-grade inflammation, which together contribute to functional decline and tissue remodeling across organs. We previously reported that long-term nacre extract supplementation can delay age-related deterioration when initiated early; however, whether it can provide benefit under post-onset intervention conditions remains unclear. Here, we evaluated a water-soluble nacre extract derived from Pinctada fucata using (i)...

CONCLUSIONS: The study findings showed a low level of awareness of the concept of active ageing among older adults in a tertiary care clinic in Saudi Arabia. Greater awareness of active ageing was positively associated with better quality of life among older adults, despite limited familiarity with the concept. These findings highlight the importance of integrating active ageing education into healthcare services and public health initiatives to support healthier and more fulfilling ageing...

A surprising new study suggests that completely eliminating sugar may backfire. Mice on a sucrose-free low-fat diet showed worse blood sugar control, increased inflammation, disrupted gut bacteria, and signs of fatty liver compared with mice that consumed some sucrose. Researchers say the results highlight the importance of a balanced diet and a healthy gut microbiome rather than focusing solely on cutting out sugar.

People taking popular weight-loss drugs such as Ozempic, Wegovy, Mounjaro, and Zepbound may be losing pounds, but they could also be moving less. Researchers analyzing Fitbit data found that daily step counts and exercise levels dropped after people started these medications, despite successful weight loss. Because the drugs can reduce muscle mass along with fat, the decline in physical activity raises concerns about preserving strength and long-term health.

A new international study finds that middle-aged Americans are lonelier, more depressed, and experiencing worse memory and health than earlier generations. Researchers say growing financial strain, weaker social supports, and chronic stress may explain why the U.S. is falling behind other wealthy nations.

A three-year study of nearly 4,000 adults ranging from age 19 to 94 found that brain health can improve at any age, challenging the common belief that mental sharpness must decline as we get older. Participants spent just a few minutes a day on brain-training activities, and researchers found measurable gains across multiple aspects of brain health, including thinking clarity, emotional well-being, and sense of purpose.

Learning a musical instrument later in life may help keep the brain younger for longer. In a four-year study, older adults who continued practicing maintained their memory performance and showed less age-related brain shrinkage than those who quit. The benefits were especially noticeable in brain regions tied to memory and learning.

Amyloid-β (Aβ) accumulation in the brain is a defining pathological feature of Alzheimer's disease (AD). Cerebral Aβ burden is regulated not only by central production and degradation but also by its transport and clearance in the peripheral circulation. Blood-borne Aβ carriers provide a potential peripheral route for reducing brain Aβ levels by strengthening the brain-to-blood concentration gradient, representing a therapeutic strategy that does not require direct penetration of the blood-brain...

Maternal sleep deprivation (MSD) is a common but usually unnoticed issue during pregnancy, and in recent years, it has been increasingly recognised as an important prenatal stressor that may adversely influence maternal physiology, placental function, and fetal neurodevelopment. Sleep disturbances during pregnancy, including reduced sleep duration, fragmented sleep, poor sleep quality, circadian disruption, and rapid eye movement sleep restriction, have been associated with altered...

CONCLUSIONS: CT-based body composition changes, atrophy of thigh muscles in particular, are associated with loss of muscle strength and physical performance.

Advances in our understanding of the biology of skeletal muscle ageing are being made at pace, with great potential for these findings to inform the identification of novel treatments for sarcopenia. However, translation of findings from animal models to humans has been hampered by limitations of existing human muscle biopsy studies. Devised to directly address this challenge, the Muscle Ageing and Sarcopenia Study (MASS) Lifecourse is a novel resource for the study of human muscle ageing. This...

Introduction Physical and cognitive impairment constitute large burdens of disease in older adults, but may be preventable through reduction of modifiable risk factors. While chronic stress has been linked to cognitive and physical function separately, few studies have accounted for combined decline. This study assessed associations between exposure to stressful life events (SLEs) and cognitive decline, physical decline, and combined physical and cognitive decline. Methods Data were taken from...

Although its evolutionary origins remain poorly understood, sleep is a highly conserved physiological process crucial to animal life and widely recognized as a major determinant of human healthspan. Sleep disturbances are a major public health concern, particularly among older adults, contributing to impaired cognitive function, chronic disease risk, and reduced quality of life. Age-related sleep disturbances are associated with epigenetic changes, especially altered DNA methylation patterns...

Oropharyngeal squamous cell carcinomas (OPSCCs) frequently result from oncogenic human papilloma virus (HPV) infections (HPV-OPSCC). The mechanisms underlying effective immune escape, despite abundant viral antigens, are incompletely understood. Here, we performed single-cell spatial gene expression profiling of HPV-OPSCC to characterize cellular organization and mechanisms of immune resistance. We describe distinct tumor-parenchymal immune foci that differ in cytokine expression, spatial...

Oogenesis requires complex interactions between germline and somatic cell types in the ovary. How did these cell types and their signaling interactions evolve? Here we use the sea star Patiria miniata as a non-chordate deuterostome representative to define the ovarian cell type toolkit in echinoderms. Sea stars continuously produce millions of new oocytes throughout their lifespan, making them a practical system to understand the mechanisms that drive oogenesis from a biomedical and evolutionary...