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The region’s enormous herbivores, some weighing more than 1 ton, were no match for this prehistoric beast

The long-delayed 12 solicitations only cover some disciplines—and promise to give them much less money

A widely prescribed blood pressure drug was associated with a 33% higher risk of serious kidney problems in people with type 2 diabetes, even when they were already taking kidney-protective medications. The surprising finding is prompting researchers to question whether DCCBs are always the safest second-line choice for diabetic kidney disease.

Researchers have built microscopic, light-driven robots that can rapidly navigate through liquid, collect bacteria, and deposit them in chosen locations. These tiny “cleaners” could open new possibilities for manipulating cells and microbes with remarkable precision.

Traveling electrical waves sweeping across the brain may help determine what we notice, predict what comes next, and construct our internal picture of the world. Researchers now argue that these waves aren't just background activity—they could be a core computational engine behind perception and memory.

Study of tree shrews points to specific wavelengths of light that might help stave off myopia

Alzheimer's disease (AD) is a multifactorial disorder that requires combined therapeutic strategies beyond amyloid clearance. Although GLP-1 receptor agonists show strong mechanistic rationale and supportive epidemiological signals for neuroprotection, large randomized trials in symptomatic AD have yielded negative clinical outcomes and do not support the therapeutic use in AD.

Advanced age is accompanied by progressive metabolic, nutritional, mitochondrial, and neuroimmune dysregulation, which may increase susceptibility to neurodegenerative disorders such as Alzheimer's disease (AD) and Parkinson's disease (PD), highlighting the need to identify modifiable mechanisms that influence disease initiation and progression. Increasing evidence indicates that nutrition, sleep, and circadian rhythms function as an interconnected biological network regulating metabolic...

Alzheimer's Disease (AD), the most prevalent cause of dementia worldwide, is a neurodegenerative disorder that currently has no cure. A growing body of evidence suggests that physical exercise is a potential non-pharmacological strategy in the treatment of AD. Recent findings highlight the involvement of autophagy in the modulatory actions of physical exercise for AD. Here, we present a narrative review of the current knowledge on how exercise impacts AD, specifically focusing on its regulation...

Ding et al. mapped over 7,000 plasma proteins to more than 40 cell types and developed machine learning aging clocks across 60,000 individuals, demonstrating that cell-type-specific biological aging is heterogeneous, measurable from blood alone, and powerfully predictive of neurodegenerative disease, cancer, and mortality up to 15 years before clinical onset.¹.

High-throughput single-cell omics of non-human primate brain tissue provides a powerful platform to investigate the molecular basis of brain aging. Here, we present a comprehensive transcriptomic and chromatin accessibility atlas of 2,955,873 nuclei from eight brain regions of 23 female cynomolgus macaques spanning the adult lifespan, including exceptionally old individuals. Our analyses reveal dynamic, cell-subtype- and region-specific age-related changes in core brain functions, including...