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Resident tissue macrophages maintain intraocular pressure homeostasis

4 days 2 hours ago
Intraocular pressure is tightly regulated by the conventional outflow tissues, preventing ocular hypertension that leads to neurodegeneration of the optic nerve, or glaucoma. Although macrophages reside throughout the conventional outflow tract, their role in regulating intraocular pressure remains unknown. Using macrophage lineage-tracing approaches, we uncovered a dual macrophage ontogeny with distinct spatial organization across the mouse lifespan. Long-lived resident tissue macrophages were...
Katy C Liu

Sleep deprivation exhibits an age-dependent effect on infraslow global brain activity

4 days 2 hours ago
Infraslow (<0.1 Hz) global brain activity, quantified by the global mean blood-oxygenation-level-dependent (gBOLD) signal in resting-state functional magnetic resonance imaging (fMRI), is elevated during sleep and coupled to cerebrospinal fluid (CSF) dynamics, a key pathway for the brain waste clearance implicated in neurodegenerative disorders such as Alzheimer's disease. However, the effect of sleep deprivation on gBOLD activity and its interaction with aging remain poorly understood. Using a...
Yibing Yang

Histone modification clocks for robust cross-species biological age prediction and elucidating senescence regulation

4 days 2 hours ago
Histone modifications represent an untapped resource for biological age prediction that overcomes limitations of traditional DNA methylation-based epigenetic clocks. Here, we developed and validated histone modification-based epigenetic clocks by systematically analyzing publicly available ChIP-seq datasets spanning six tissue types and six histone marks. We identified age-associated loci and constructed 36 tissue-specific epigenetic clocks that demonstrated strong resilience to technical and...
Zhixin Niu

Sleep deprivation exhibits an age-dependent effect on infraslow global brain activity

4 days 2 hours ago
Infraslow (<0.1 Hz) global brain activity, quantified by the global mean blood-oxygenation-level-dependent (gBOLD) signal in resting-state functional magnetic resonance imaging (fMRI), is elevated during sleep and coupled to cerebrospinal fluid (CSF) dynamics, a key pathway for the brain waste clearance implicated in neurodegenerative disorders such as Alzheimer's disease. However, the effect of sleep deprivation on gBOLD activity and its interaction with aging remain poorly understood. Using a...
Yibing Yang

Impacts of parental age and inbreeding on fitness in a wild insect

4 days 2 hours ago
Parental age and inbreeding have both been shown to have substantial fitness effects in laboratory experiments and in observations of wild animals. These demographic effects are likely to be strongly impacted by habitat fragmentation and warming temperatures, so understanding them is a priority. In insects and other ectotherms, some processes implicated in senescence are dependent on temperature. Anticipated changes in climate may therefore have direct effects on senescence in insects, or...
Tom Tregenza

No evidence lithium supplementation extends lifespan in male Drosophila melanogaster

4 days 2 hours ago
Pharmacological modulation of ageing is viewed as a viable route to extending lifespan and healthspan, yet the efficacy of putative geroprotectors may depend strongly on physiological and environmental context. Lithium chloride (LiCl) has been reported to extend lifespan in several model organisms, but evidence remains inconsistent and the role of reproductive investment-an energetically costly and often lifespan-correlated process-has rarely been examined. We tested the effects of dietary LiCl...
Andrew William McCracken