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Ultrafast and reference-free sequence discovery in single-cell data
Systems vaccinology and the architecture of human immunity
Insights into longevity and virus-driven adaptation from <i>Myotis</i> bat genomes
Automated prototyping of genetic codes
Using nuclear waste to power space missions
Highest-ever ocean temperatures recorded as El Niño intensifies
Like coffee and ice cream: an interview with Sam and Eli Morten
The baffling science of SSRIs: how do they really work?
South Africa’s ‘registration law’ for scientists could be a template for the world — if the nation gets it right
Shingles vaccine linked to reduced heart risks
New data add weight to idea that immunization protects against more than just the chickenpox virus
NSF shrinks support for social sciences in prestigious graduate fellowship program
New solicitation excludes students in seven fields and science education
NASA’s Roman telescope readies a sweeping view of the universe
With a view 100 times larger than Hubble, the observatory will survey the cosmos for distant worlds and clues to dark energy
Your genes may decide whether a low-carb diet sends cholesterol soaring
A low-carb diet may raise LDL cholesterol much more sharply in people who are genetically predisposed to high cholesterol, particularly when they consume lots of saturated fat. The findings could help explain why people following seemingly similar diets can have dramatically different results.
Your brain may not actually “make” decisions
A neuroscientist is challenging the idea that the brain contains a central system that actually “makes” our decisions. What we experience as choosing may instead emerge from the continuous interaction of perception, movement, the body, and the world around us.
Shingles vaccine linked to 24% lower dementia risk
Older adults who received the Shingrix shingles vaccine were 24% less likely to be diagnosed with dementia over four years in a study of more than 500,000 people. Researchers estimate the difference could amount to roughly one dementia case prevented for every 17 people vaccinated.
Supercharged “natural killer” cells could be a powerful new cancer weapon
Researchers have found a way to supercharge natural killer cells, powerful immune cells that can attack cancer, so they can penetrate solid tumors and keep fighting once inside. In mice, these specially prepared tissue-resident cells slowed the growth of several tumors, including melanoma and head and neck cancers, and worked even better when paired with the antibody drug cetuximab.
To predict tree death, scientists tapped gamma rays to peer underground
Airborne radiation sensors could help forecast and prevent drought-driven tree mortality
A bioorthogonal nanoconcentrisome system for epigenetic and immunometabolic reprogramming of tissue regeneration in aged female rats
Stem cell-based therapies show promise for tissue regeneration but are limited by therapeutic instability, particularly in aged tissues. Here, multi-omics profiling of regenerating bone reveals marked depletion of S-adenosylmethionine (SAM), indicating epigenetic dysregulation associated with impaired repair. To address this, we develop a spatially compartmentalized, fusogenic nanovesicle system (SMNV), termed a "nanoconcentrisome," composed of SAM-loaded fusogenic liposomes encapsulating...
Aging regulation by gut microbiota: molecular insights from Caenorhabditis elegans
Aging is a complex biological process governed by conserved genetic and metabolic pathways. Increasing evidence has identified the gut microbiota as a critical modulator of host aging and healthspan. The Caenorhabditis elegans model provides a powerful system to elucidate the molecular determinants of this cross-kingdom dialogue. Recent advances in this model organism reveal that gut microbes may regulate aging through two distinct yet convergent mechanisms: (i) the production of small-molecule...
Aging by impaired efferocytosis
No abstract