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Reply to: On the robustness of topological gap detection via transport
Role of methanesulfonic acid in atmospheric particle nucleation and growth
Author Correction: cBAF complex components and MYC cooperate early in CD8<sup>+</sup> T cell fate
Why science needs the humanities more than ever
‘Us’ not ‘them’: scientists must use their skills to help stop polarization and division
Study challenges a common belief about vitamin D and sunlight
A study of nearly 300 people across northern Britain found that vitamin D levels often stay low all year in groups most at risk. Surprisingly, summer sunshine did not significantly boost vitamin D levels among older adults or people from minoritized ethnic backgrounds.
The universe is unexpectedly stringy, which could unravel the theory of the cosmos
Controversial claim challenges principle of cosmological sameness on which prevailing theory rests
Migrating sea turtles only sort of know where they’re going
An “approximate” sense of Earth’s magnetic fields means the animals must occasionally reorient during long ocean voyages
Medical students are using a popular research tool to pump out misleading studies
Critics say TriNetX’s easy analyses of electronic medical records fuel quick-and-dirty publications from inexperienced authors
One tiny mutation may explain how bat viruses become human threats
Scientists found that one tiny genetic change can completely alter how a coronavirus behaves in different species. Comparing SARS-CoV-2 with a closely related bat-only virus, they showed that a single amino-acid difference affects whether the immune system fights back or gets suppressed. This may help explain how some animal viruses make the leap to humans and become far more dangerous.
After menopause, ovaries may transform into organs with immune powers
Mouse and human data suggest ovaries develop a new function after reproductive duties end
The tea in your kombucha changes more than just the taste
Scientists discovered that kombucha’s flavor, chemistry, and antioxidant activity vary dramatically depending on the tea used to make it. Green and oolong tea kombuchas emerged as the most biologically active, while fermentation transformed each tea into a distinctly different beverage.
Scientists finally solved how H5N1 bird flu hid in dairy cows
Researchers uncovered why H5N1 bird flu attacks cows’ udders instead of their lungs: the virus’s preferred receptors are concentrated in mammary tissue. The breakthrough could help scientists predict future bird flu jumps and spot unusual infections before they spread widely.
New brain study reveals speech learning works differently than we thought
A new study suggests that learning and remembering speech relies more on how the brain processes sounds and sensations than on the areas that control mouth and face movements. The discovery could reshape speech therapy and help improve future brain-based communication technologies.
One of the world’s most popular weedkillers may be fueling deadly superbugs
Researchers found that highly drug-resistant bacteria from hospitals are also resistant to glyphosate, a commonly used weedkiller. The discovery suggests that agricultural herbicides may be helping antibiotic-resistant microbes survive and spread far beyond healthcare settings.
How AI, $1 billion, and a transparent fish could transform neuroscience
The once-obscure Danionella fish takes center stage as a model research organism in a major new project funded by Howard Hughes Medical Institute
Bromodomain protein 4 (BRD4) as a central epigenetic regulator in neuropsychiatric and neurodegenerative disorders
Bromodomain-containing protein 4 (BRD4), a member of the bromodomain and extra-terminal (BET) family, is a central epigenetic regulator that links histone acetylation-dependent chromatin remodelling to transcriptional control. Through recognition of acetylated lysine residues and recruitment of transcriptional machinery, it is increasingly recognised as a critical regulator of neuronal and glial functions, influencing synaptic plasticity, neuroinflammation, learning, memory, and behavioural...
Necroptosis in Down Syndrome
Necroptosis is a form of controlled cell death implicated in neuronal loss observed in neurodegenerative diseases such as Alzheimer's disease. Down syndrome (DS) is also characterized by the presence of neuronal cell loss, but the underlying mechanisms remain unclear. Brain tissue from a mouse model of DS, Ts65dn mice, and subjects with DS were assessed for levels of necroptosis markers including receptor-interactive protein kinase 1 and 3, necroptosis executor mixed lineage kinase domain-like...
Methionine-supplemented longevity diet increases growth hormone, GLP-1, and FGF21; reduces frailty; and promotes healthspan
Southern European countries have some of the highest life expectancies in the world, yet they display relatively high frailty. We examined different diets to identify compositions that promote both healthspan and strength in mice. The western and ketogenic diets increased fat mass and frailty and increased either cholesterol or insulin resistance, whereas a low-protein longevity diet, modeling the traditional Mediterranean and Okinawan diets but supplemented with methionine (LDMM), reduced fat...
Calorie restriction and exercise differentially regulate AMP-activated protein kinase across subcellular compartments in skeletal muscle from older male rats
AMP-activated protein kinase (AMPK) is a crucial energy sensor that regulates a wide range of important processes in skeletal muscle. AMPK is present in several subcellular compartments (including the cytosol, nucleus, and mitochondria). However, the influence of physiologically relevant interventions on AMPK's localization in skeletal muscle is not well understood, especially during older age. Accordingly, this study examined AMPK signaling in skeletal muscle from aged male rats...