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Hidden sugar patterns on human cells could reveal cancer early

3 days 12 hours ago
Scientists have uncovered a hidden “sugar code” on the surface of human cells that could transform how diseases are detected. Using an advanced imaging technique called Glycan Atlasing, researchers at the Max Planck Institute mapped the tiny sugar structures coating cells and discovered that these patterns shift depending on what the cell is doing. Immune cells changed their sugar layouts when activated, and cancerous tissues displayed distinct surface signatures compared to healthy tissue.

Eating grapes daily could unlock powerful skin protection

3 days 13 hours ago
Scientists discovered that eating grapes can actually change how your skin behaves at the genetic level. After just two weeks of daily grape consumption, volunteers showed signs of improved skin protection and reduced oxidative stress from UV exposure. Researchers say the effects appear widespread, even though every person’s genes responded a little differently.

Predicting categorical and continuous Alzheimer's disease outcomes from a single MRI scan

4 days 2 hours ago
Deep learning (DL) has shown success in predicting Alzheimer's disease (AD) diagnosis, yet continuous measures such as cognitive assessment remain critical for richer prognosis, trajectory tracking and clinical trial enrichment. Current neurocognitive batteries are time-consuming, and the few DL models predicting cognition require expensive multimodal neuroimaging and longitudinal data. Although magnetic resonance imaging (MRI) is the most clinically accessible modality, on its own it struggles...
Daren Ma

Spatial proteomic analysis in human Alzheimer's disease brains enables identification of microenvironment-dependent microglial cell states

4 days 2 hours ago
Disease-associated microglial states are thought to contribute to Alzheimer's disease (AD) progression, but characterizing them and their relationships to pathology remains challenging. Here we introduce CODEX-CNS-a multiplexed protein imaging technology with a custom data analysis pipeline for use in human brain samples. We profiled 704,706 cells in samples from the frontal cortex of 8 people with AD and 8 healthy controls and mapped features including blood-brain barrier, meningeal components...
Paula Sanchez-Molina

Rethinking insulin resistance in aging: A reserve-oriented clinical framework

4 days 2 hours ago
Ageing represents one of the strongest non-modifiable determinants of insulin resistance (IR), a condition that extends well beyond impaired glucose handling and underling a broad spectrum of metabolic, cardiovascular, and neuropsychiatric disorders. In older adults, IR emerges from the progressive loss of physiological reserve across multiple organ systems rather than from isolated defects in insulin signalling. This narrative review examines the metabolic, inflammatory, and hormonal mechanisms...
Virginia Boccardi

Maternal age and pregnancy-related cardiovascular complications

4 days 2 hours ago
Pregnancy-related cardiovascular complications cause substantial morbidity and account for a large proportion of maternal deaths. The relationship between maternal age and pregnancy-related cardiovascular complications remains unclear. Most prior studies categorized patients using an age threshold, and previous studies did not delineate patients' baseline cardiovascular risk versus pregnancy-specific risk. Here we show that pregnancy and the postpartum period are associated with a 7-fold higher...
Hooman Kamel

Cardiolipin preserves T<sub>reg</sub> metabolic fitness and immune homeostasis in the gut

4 days 2 hours ago
Loss of host-microbiota balance promotes gut inflammation, colitis and inflammatory bowel disease. Yet, whether host or microbial factors are the critical driver of the pathology remains unclear. Here, we investigate how cardiolipin maintains metabolic fitness of regulatory T (T(reg)) cells to preserve gut-immune homeostasis. We discover that deleting the cardiolipin-synthesizing enzyme protein tyrosine phosphatase mitochondrial 1 (PTPMT1) in T cells predisposes mice to colitis due to impaired...
Annamaria Regina

Spatial proteomic analysis in human Alzheimer's disease brains enables identification of microenvironment-dependent microglial cell states

4 days 2 hours ago
Disease-associated microglial states are thought to contribute to Alzheimer's disease (AD) progression, but characterizing them and their relationships to pathology remains challenging. Here we introduce CODEX-CNS-a multiplexed protein imaging technology with a custom data analysis pipeline for use in human brain samples. We profiled 704,706 cells in samples from the frontal cortex of 8 people with AD and 8 healthy controls and mapped features including blood-brain barrier, meningeal components...
Paula Sanchez-Molina

Identifying a fitness tool in early old-age to predict long-term risk of disability, severe disability, and mortality

4 days 2 hours ago
Population ageing has led to an increase in prevalence of old-age disability but whether the risk of disability can be detected early remains unclear. We used ten functioning/fitness measures in early old-age to identify their predictive ability for disability at older ages. A total of 4593 participants of the Whitehall II study, mean age 65.3 years, were followed for a median of 11.00 (IQR 7.25-12.67) years for incident disability [≥ 1 limitation in activities of daily living (ADL)], and severe...
Céline Ben Hassen

Biological brain aging, cognitive-motor decline and vascular risk: a multivariate imaging analysis of 40,579 individuals

4 days 2 hours ago
INTRODUCTION: Age-related declines in cognitive and motor functions show highly variable trajectories. To better understand the underlying mechanisms, we investigated multivariate associative effects between modifiable vascular risk factors, biological brain aging, cognitive, and motor performance in 40,579 individuals from the population-based UK Biobank and Hamburg City Health Study.
Marvin Petersen