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Memory T cell aging and rejuvenation
Aging reshapes T cell immunity, as evidenced by eroding naive diversity and remodeled memory hierarchies. This generates an experienced yet constrained repertoire, with weakened protection against novel infections and malignancies and blunted vaccine responsiveness. However, the pace and extent of decline vary widely between individuals. Such heterogeneity signals a recalibration of immune priorities that favors persistence over plasticity of memory T cells. Here, we discuss how aging shapes...
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Science, Volume 392, Issue 6793, April 2026.
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Science, Volume 392, Issue 6793, April 2026.
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Science, Volume 392, Issue 6793, April 2026.
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Science, Volume 392, Issue 6793, April 2026.
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Science, Volume 392, Issue 6793, April 2026.
Mitochondrial metabolism and signaling direct dendritic cell function in antitumor immunity
Science, Volume 392, Issue 6793, April 2026.