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Recurrence or persistence of atrial fibrillation is associated with frailty and adverse outcomes: the SAGE-AF cohort study

4 days 7 hours ago
CONCLUSION: Frailty or pre-frailty increases odds of AF recurrence or persistence at two years, underscoring the potential role of biological aging in influencing the course of AF over time. AF recurrence or persistence was associated with greater hazards of major bleeding, even after adjustment for key clinical factors, suggesting residual risk not captured by measured covariates.
Bahjat Z Ghazzal

Management and coping with care for older adults: family caregivers' experiences in Enugu state, Nigeria

4 days 7 hours ago
CONCLUSION: An increase in age comes with an increase in care management demands, with concerns affecting the management and strategies adopted in coping with care for older adults. Since the Nigerian society does not support institutionalized homes for older adults, we recommend the utilization of social workers' services in family settings, through providing appropriate care management strategies and services for older adults and their family caregivers.
Jacinta Chibuzor Ene

Home- and community-based services, informal support networks, and life satisfaction among older adults in China: moving beyond filial support

4 days 7 hours ago
CONCLUSION: Aging policies must move beyond traditional assumptions of filial support, as empirical evidence uncovers that broader informal ties-particularly instrumental networks-now exert a stronger relative impact on well-being than traditional family care. Furthermore, HCBS is not a one-size-fits-all solution; its benefits are geographically masked, primarily accruing to rural and functionally capable elders. The interplay between formal and informal care features emotional synergy and...
Jinfu Xu

The association between smart elderly care and subjective well-being among older adults in China: the mediating roles of health status and social activities

4 days 7 hours ago
CONCLUSIONS: This study challenges the prevailing assumption that the "digital divide inevitably isolates the older adults from participating in a digitized society." By integrating digital technologies into older adults care services, we demonstrate that smart elderly care is positively associated with bridging technological barriers and addressing the unmet needs of aging populations. These findings further propose a synergistic mechanism-policy innovation, technological adaptation, and...
Keyi Huang

Multidomain prediction of education-stratified MoCA-defined mild cognitive impairment in community-dwelling older adults in urban China

4 days 7 hours ago
CONCLUSIONS: Multidomain predictors spanning objective movement behaviours, body-composition indicators, and built-environment measures showed value for identifying education-stratified MoCA-defined MCI in community-dwelling older adults. LightGBM achieved the best overall performance among the candidate models. These findings support the potential utility of integrating behavioural, biological, and environmental information for community-based cognitive-risk stratification, although external...
Zhijian Wu

Why grandparents matter more than ever for children's mental health

4 days 8 hours ago
A child psychologist says grandparents are more important than ever as youth mental health challenges continue to rise. He argues that children need supportive relationships, meaningful conversations, and a sense of purpose—not just pressure to achieve. Grandparents can help by listening, encouraging, and creating positive experiences that strengthen emotional resilience.

A hidden gene finally explains this rare neurological disorder

4 days 10 hours ago
Scientists have uncovered a surprising new genetic cause of a rare movement disorder after analyzing nearly 3,000 patients with conditions affecting coordination and muscle control. The team identified mutations in a gene called CD99L2, previously linked only to the immune system, and showed that it plays an essential role in keeping nerve-cell communication running smoothly.

New fentanyl vaccine blocks deadly overdoses before they start

4 days 12 hours ago
A new experimental vaccine developed by Scripps Research could offer a powerful new way to prevent fentanyl overdoses by stopping the drug before it reaches the brain. Rather than targeting only fentanyl itself, the vaccine trains the immune system to recognize a broad range of fentanyl-related designer drugs, including some of the most dangerous variants.

These tiny holes could change how the world cleans water

5 days 4 hours ago
A new nature-inspired membrane uses perfectly uniform one-nanometer pores to filter molecules with remarkable precision. The technology could transform industries such as pharmaceuticals and textiles by reducing energy consumption, improving water reuse, and delivering separation performance far beyond current filters.

Recent advances in neurodegenerative diseases therapeutics: The inhibition of monoacylglycerol lipase strategy

5 days 7 hours ago
Neurodegenerative diseases share common pathophysiological mechanisms, including chronic neuroinflammation, glutamatergic excitotoxicity, oxidative stress, mitochondrial dysfunction, and disruptions in synaptic and lipid homeostasis. In this context, the endocannabinoid system has emerged as a key modulator of neuroimmune communication and neuronal survival. Within this system, Monoacylglycerol Lipase (MAGL) plays a central role by regulating the levels of the endocannabinoid...
Delia Maciel Mendoza-Camacho

Comparison of count-based and clustering definitions of multimorbidity and their association with prevalence of multimorbidity, health profiles, and mortality: A cohort study of UK Biobank participants

5 days 7 hours ago
CONCLUSION: Operational definitions of multimorbidity substantially influence prevalence estimates, while associations with mortality appear more robust across count-based approaches. Clustering analyses provide complementary insights into heterogeneity within multimorbid populations. Future translational studies are warranted to determine how multimorbidity definitions can be optimized to ultimately improve clinical management and health outcomes in practice.
Gabriella C Silva

Age-related differences in how tDCS priming modulates cortical inhibition during fatigue recovery

5 days 7 hours ago
Metaplasticity is homeostatic regulation of brain excitability through which neurons change their threshold for response based on synaptic history. Transcranial direct current stimulation (tDCS) induced metaplastic shifts in cortical excitability have been shown to improve motor learning in older adults. However, this has not been explored in the context of a fatiguing contraction. We aimed to explore modulation of fatiguing exercise performance, corticospinal excitability and gamma-aminobutyric...
Eva K Moore

Co-regulatory mechanisms of skin and hair aging

5 days 7 hours ago
As a cutaneous appendage, the hair follicle is tightly associated with the skin during growth, pigmentation, and aging. These two interconnected tissues share evolutionarily conserved regulatory mechanisms-including stem cell niche signaling, inflammatory cascades, and oxidative stress-and collectively function as hallmarks of systemic organismal aging. Hair abnormalities are well-established concomitant manifestations of aged skin. The crosstalk between skin aging and hair aging is particularly...
Hong Wu

A progeria syndrome links DNA hypermethylation to age-related pathology

5 days 7 hours ago
Declining tissue function and regenerative capacity underlie many chronic diseases. Experimentally establishing the mechanistic basis for such tissue aging presents substantial challenges, given decades-long timescales and multifactorial origins. Epigenetic alterations have been proposed to have a key etiological role, but whether they are correlative or causal remains a key unanswered question, as does their contribution to specific age-related pathologies. Here we describe an epigenetically...
Dan Sarni