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Enigmatic muscle may help explain penguins’ signature waddle
Find also reveals how the birds keep their bodies streamlined when underwater
‘Modern European family’ predates fall of Rome, DNA reveals
Painstaking pedigrees hint at origins and social norms of people living near Rome’s northern frontier
Battle over DNA within fertilized eggs may explain why some IVF procedures fail
Temporarily keeping parents’ genetic contributions separate promotes normal development, mouse study suggests
The role of ultrasound in addressing neurodegenerative diseases: A review of mechanisms, applications, and challenges
With the aging of the global population, neurodegenerative diseases have become a major public health challenge. Currently, there are many limitations in the traditional treatment of neurodegenerative diseases, such as medicine, deep brain stimulation, transcranial magnetic stimulation, and transcranial direct current stimulation, including the inability to penetrate the blood-brain barrier (BBB) accurately and challenges in achieving precise and quantitative control during the treatment...
Serious side effects of Alzheimer's immunotherapy demand scrutiny
Monoclonal antibodies targeting amyloid-β, i.e., lecanemab and donanemab, have recently been approved for treating early Alzheimer's disease (AD). Though these antibodies are by many considered milestones in AD therapy, clinical approvals have been inconsistent due to ongoing debates over their clinical benefit and safety. The reported cognitive decline slowing is modest and often below the thresholds for clinically significant differences on outcome scales. Moreover, these therapies are linked...
Tiny Titans, big promise: Nanotechnology and microRNA in the fight against Alzheimer's disease
Alzheimer's disease (AD) remains the most common neurodegenerative disorder. It is driven by complex molecular dysfunctions that includes amyloid aggregation, tau pathology, and neuroinflammation. It leads to cognitive deficits and memory loss in elderly people. Current treatments offer limited symptomatic relief. Hence, there is urgent need for innovative therapeutics and diagnostic approaches. Among emerging therapeutic targets, microRNAs (miRNAs) have pivotal role in regulating genes linked...
The role of ultrasound in addressing neurodegenerative diseases: A review of mechanisms, applications, and challenges
With the aging of the global population, neurodegenerative diseases have become a major public health challenge. Currently, there are many limitations in the traditional treatment of neurodegenerative diseases, such as medicine, deep brain stimulation, transcranial magnetic stimulation, and transcranial direct current stimulation, including the inability to penetrate the blood-brain barrier (BBB) accurately and challenges in achieving precise and quantitative control during the treatment...
Uridine restores oocyte quality and mitigates female reproductive aging by inhibition of ferroptosis in mice
Advanced maternal age is a key factor in female infertility, primarily due to declines in ovarian reserve and oocyte quality. However, the metabolic mechanisms underlying reproductive aging remain unclear. Here, we show that uridine levels in the plasma and ovaries of aged mice are significantly reduced compared with young controls. Building on this, we find that uridine supplementation significantly improves meiotic maturation, fertilization, and early embryonic development of aged oocytes,...
Aging-associated modulation of UFMylation impairs proteostasis in C. elegans
The attachment of Post-Translational Modifications (PTMs) to proteins regulates their activities and stability. Here we utilized the nematode Caenorhabditis elegans to test whether UFMylation, a PTM which affects key biological functions, regulate aging and protein homeostasis (proteostasis). We find that lowering UFMylation extends lifespan and mitigates the toxicity of aggregation-prone proteins that underlie the development of neurodegenerative disorders in humans. Mass spectrometric analysis...
Multimodal data analysis reveals asynchronous aging dynamics across female reproductive organs
Female reproductive aging has systemic health implications, yet tissue-level dynamics remain poorly understood. Here we integrate deep learning analysis of 1,112 histology images with RNA sequencing from 659 samples across seven female reproductive organs in donors aged 20-70 years. We uncover asynchronous trajectories: the ovary ages gradually, whereas the uterus shows an abrupt molecular and morphological shift around menopause. This uterine transition is independently supported by plasma...
Witnessing Interparental Violence in Childhood and Frailty in Adulthood: Evidence From a National Population-Based Study in China
CONCLUSIONS AND IMPLICATIONS: Witnessing interparental violence in childhood is significantly linked to higher frailty in adulthood. Interventions addressing domestic violence may contribute to healthier aging outcomes.
Low overlap of plasma and CSF protein quantitative trait loci affects protein discovery for neurological disease
Plasma protein quantitative trait loci (pQTLs) have been integrated with genetic studies to prioritize proteins implicated in numerous human diseases. However, limited interaction between plasma and the central nervous system decreases the fluid's relevance for neurological disease. We compared the pQTL landscapes between plasma and cerebrospinal fluid (CSF), detecting widespread differences across fluids that translate to the identification and prioritization of proteins and pathways implicated...
RETRACTION: The 12-15-Lipoxygenase is a Modulator of Alzheimer's-Related Tau Pathology In Vivo
P. F. Giannopoulos, Y. B. Joshi, J. Chu, and D. Praticò, "The 12-15-Lipoxygenase is a Modulator of Alzheimer's-Related Tau Pathology In Vivo," Aging Cell 12, no. 6 (2013): 1082-1090, https://doi.org/10.1111/acel.12136. The above article, published online on 17 July 2013 in Wiley Online Library (wileyonlinelibrary.com), has been retracted by agreement between the journal Editor-in-Chief, Monty Montano; The Anatomical Society; and John Wiley & Sons Ltd. The retraction has been agreed upon...
Replacement-Based Ageing Interventions for Systemic Rejuvenation: Shaping Longevity Science and Clinical Directions
Biological and synthetic replacement-based ageing interventions hold substantial potential to reverse many forms of age-related damage simultaneously and extend healthy lifespan beyond what can be achieved with conventional therapeutics. In this Perspective, we discuss recent insights, unmet needs, and emerging trajectories that are catalysing research and clinical development of replacement-based treatments and synergistic strategies for multi-targeted damage removal and export at the...
RETRACTION: The 12-15-Lipoxygenase is a Modulator of Alzheimer's-Related Tau Pathology In Vivo
P. F. Giannopoulos, Y. B. Joshi, J. Chu, and D. Praticò, "The 12-15-Lipoxygenase is a Modulator of Alzheimer's-Related Tau Pathology In Vivo," Aging Cell 12, no. 6 (2013): 1082-1090, https://doi.org/10.1111/acel.12136. The above article, published online on 17 July 2013 in Wiley Online Library (wileyonlinelibrary.com), has been retracted by agreement between the journal Editor-in-Chief, Monty Montano; The Anatomical Society; and John Wiley & Sons Ltd. The retraction has been agreed upon...
Unequal healthy ageing trajectories across Europe: socioeconomic development and age-related disease burden in the European Union and South-Eastern European countries
Although life expectancy has increased, many of the added years are lived in poor health, highlighting growing inequalities in ageing trajectories. Despite the increasing need for ageing-related health strategies, non-EU European countries remain underrepresented in comparative research, leaving limited evidence on healthy ageing disparities between EU and South-Eastern European (SEE) nations. This study explored variations in key health and socioeconomic indicators of societal ageing and...
A telomere-lipid-immunity axis linking viral integration to autoimmune disease risk
Autoimmune diseases rise steeply with biological aging, reflecting progressive failure of immune regulation. Inherited chromosomally integrated human herpesvirus 6 (iciHHV-6) represents a unique lifelong viral exposure in which the viral genome is embedded within host telomeres, potentially altering leukocyte telomere length (LTL), a core biomarker of immune aging. Circulating metabolites may further modify these viral-telomeric interactions. We analyzed 156,927 UK Biobank participants free of...
Characterizing Home-Based Primary Care, Palliative, and Hospice Cohorts to Optimize Service Integration and Referral Timing
No abstract
Early detection of Alzheimer's disease via multimodal MRI and machine learning
CONCLUSION: Integrating multimodal neuroimaging with ML enhances diagnostic accuracy for AD and MCI and identifies potential neuroimaging biomarkers, providing objective evidence to support early clinical intervention.
Guns and bulletproof vests: How federal agents arrested Fauci aide
David Morens, 78, was stripped and handcuffed for email violations