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Funding from Advanced Research Projects Agency for Health will expand testing of supplements and approved drugs to prevent dementia in people at risk

A study by DZNE finds that healthy eating is associated with slower biological aging—and that there is more than one way to eat healthily. The researchers examined ten dietary patterns considered healthy, including the Mediterranean, Nordic, and a plant-based diet, as well as the DASH diet, which is designed to help lower blood pressure. The findings are published in the journal Nature Communications. 

With high-speed cameras and a “pitch cannon,” researchers are refining the automated ball-strike system about to call its first World Series

Scientists have uncovered a surprising reason why statins, the widely prescribed cholesterol-lowering drugs that help prevent heart attacks and strokes, can sometimes cause muscle pain, weakness, and even severe muscle damage. Using advanced imaging technology, researchers discovered that statins can attach to a crucial protein in muscle cells and force open a channel that normally controls calcium flow. This causes calcium to leak continuously, potentially damaging muscle tissue.

Scientists have discovered a natural compound that targets dangerous C. difficile bacteria without wiping out the gut's beneficial microbes. Successful early tests suggest it could lead to a gentler, more effective treatment for stubborn intestinal infections that frequently return.

The aging brain may be undergoing a remarkable transformation rather than simply losing its abilities, shifting its focus from remembering details to understanding the bigger picture. Scientists suggest this change could be an evolutionary adaptation that helps older adults develop wisdom and share decades of knowledge with younger generations.

Epidemiological studies link kidney function to Parkinson's disease risk, but the genetic basis of this relationship remains unclear. Here, we leverage genome-wide association data for Parkinson's disease and five UK Biobank-derived kidney-related traits in individuals of European ancestry, combining genetic correlation, pleiotropy mapping, colocalization and enrichment across sex-combined and sex-stratified analyses. Genome-wide genetic correlations with Parkinson's are modest, with only a...

Although brain cholesterol dysregulation is implicated in Parkinson's disease (PD), targeting cholesterol synthesis has shown limited efficacy. Here we identify ATP-binding cassette transporter A1 (ABCA1) as a critical regulator of cholesterol homeostasis in PD. We show that ABCA1 expression is elevated in the substantia nigra of postmortem PD brains and in a PD mouse model, with regional analyses revealing preferential alterations in nigral and striatal circuits. Mechanistically, astrocytic...

The age-related decline in oocyte quality is a major risk factor for female infertility. Although transcriptome has been examined in aged oocytes, proteomic landscape, which reflects primary gene functional executors, remains largely unexplored. This gap limits our understanding of oocyte aging. To address this, we perform single-cell proteome/transcriptome co-profiling of GV/MII-aged oocytes from mice and humans, revealing species- and stage-specific proteomic/transcriptomic changes during...

What explains the large variation in lifespan across species? I examine an information-turnover proposition-that ancestral environmental variability should shorten captive lifespan after controlling for body mass, temperature and extrinsic mortality (P1), with a possible lineage-fate interaction (P2)-against the classical extrinsic-mortality prediction that safer niches permit longer life. I state the decision rules in advance rather than register a third-party protocol. Integrating AnAge (4,219...

Blood biomarkers are transforming Alzheimer's disease diagnostics by enabling a scalable, minimally invasive assessment of pathology. Food and Drug Administration clearances and European market certifications of different plasma tests mark a shift toward biological diagnosis in routine care. However, clinical implementation is not guided by diagnostic accuracy alone but will depend on improved patient-centered and pathway-level outcomes, including diagnostic confidence, the appropriate use of...

Obesity is a major metabolic disorder linked to neuroinflammation and cognitive decline. Beyond hypothalamic alterations, emerging evidence indicates that extra-hypothalamic regions, including the cerebellum, are vulnerable to obesity-induced neurotoxicity. This study investigated whether high-fat diet (HFD)-induced obesity causes cerebellar oxidative stress, impairs Na^(+),K^(+)-ATPase (NKA) activity, and triggers molecular features resembling brain aging in female Balb/C mice. Chronic 10-week...

Genetic evidence implicates immune dysfunction in Alzheimer's disease (AD), yet the neuroimmune mechanisms operating in human tissue remain poorly defined. Here, we establish a modular human forebrain organoid platform that systematically integrates human induced pluripotent stem cell-derived microglia and CD8^(+) T cells to reconstitute multicellular AD pathology. This system enables functional interrogation of both innate and adaptive immune components in a human-relevant context. Using this...

Multiple lysosomal stresses activate Parkinson's-linked LRRK2 kinase, and these involve the so-called "CASM" pathway to help recruit LRRK2 to lysosome surfaces. Clegg et al. (https://doi.org/10.1083/jcb.202511137) show that LRRK2, activated upon lysosome swelling caused by PIKfyve inhibition, instead relies solely on Rab GTPase binding for lysosome localization and activation.