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The conformational space of RNase P RNA in solution
Lithocholic acid binds TULP3 to activate sirtuins and AMPK to slow down ageing
Lithocholic acid phenocopies anti-ageing effects of calorie restriction
Nucleosome fibre topology guides transcription factor binding to enhancers
Scalable production of ultraflat and ultraflexible diamond membrane
The <i>Nature Podcast</i> festive spectacular 2024
<b>What were some </b><b>of</b><b> the biggest stories of 2024? Join us for the </b><Emphasis Type="BoldItalic">Nature Podcast</Emphasis><b> quiz!</b>
This digital-memory device keeps its cool even at 600 °C
Ancient genomes reveal a deep history of treponemal disease in the Americas
Give ‘science for peace’ a chance
Giant study finds untrustworthy trials pollute gold-standard medical reviews
Pioneering journal <i>eLife</i> faces major test after loss of impact factor
How car and battery companies can work around US trade tariffs and rules
Controversial COVID study that promoted unproven treatment retracted after four-year saga
In the space between the seconds
The small-drone revolution is coming — scientists need to ensure it will be safe
Moral conundrums and more: Books in brief
Our favorite online news stories of 2024
A roundup of some of our most popular and memorable items
Surprisingly thick ice on Jupiter’s moon Europa complicates hunt for life
Revelation is blow to hopes for habitability and future space missions
Brain change trajectories in healthy adults correlate with Alzheimer's related genetic variation and memory decline across life
Throughout adulthood and ageing our brains undergo structural loss in an average pattern resembling faster atrophy in Alzheimer's disease (AD). Using a longitudinal adult lifespan sample (aged 30-89; 2-7 timepoints) and four polygenic scores for AD, we show that change in AD-sensitive brain features correlates with genetic AD-risk and memory decline in healthy adults. We first show genetic risk links with more brain loss than expected for age in early Braak regions, and find this extends beyond...