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RORing for oral tolerance
Science, Volume 389, Issue 6757, Page 236-237, July 2025.
Disorder meets its match
Science, Volume 389, Issue 6757, Page 235-236, July 2025.
Polyglycine proteins leave transfer RNAs unglued
Science, Volume 389, Issue 6757, Page 234-234, July 2025.
A new age of molecular chirality
Science, Volume 389, Issue 6757, Page 232-233, July 2025.
In Other Journals
Science, Volume 389, Issue 6757, Page 247-248, July 2025.
Stigma did not kill my dream
Science, Volume 389, Issue 6757, Page 318-318, July 2025.
Midline assembloids reveal regulators of human axon guidance
Science, Volume 389, Issue 6757, Page 282-289, July 2025.
Global earthquake detection and warning using Android phones
Science, Volume 389, Issue 6757, Page 254-259, July 2025.
Bridging the pyridine-pyridazine synthesis gap by skeletal editing
Science, Volume 389, Issue 6757, Page 295-298, July 2025.
Dome-celled aerogels with ultrahigh-temperature superelasticity over 2273 K
Science, Volume 389, Issue 6757, Page 290-294, July 2025.
Controlled colonization of the human gut with a genetically engineered microbial therapeutic
Science, Volume 389, Issue 6757, Page 303-308, July 2025.
Two-dimensional indium selenide wafers for integrated electronics
Science, Volume 389, Issue 6757, Page 299-302, July 2025.
Skeletal editing of pyrrolidines by nitrogen-atom insertion
Science, Volume 389, Issue 6757, Page 275-281, July 2025.
Senate panel raises hopes that NSF will restore killed grants
Republicans promise to work with Democrats to salvage defeated amendment
Google alerts offer quick, cheap earthquake warnings
In 3 years, system embedded in Android phones sent warnings to millions of users in 98 countries
How a string of deadly shark attacks made a remote island a hub of lifesaving research
After 11 deaths, Réunion Island in the Indian Ocean became a center for shark attack science
Europe plans to double research spending in next Horizon Europe scheme
Starting in 2028, the EU’s flagship research program will have a new focus on boosting European competitiveness
Interpretable deep learning framework for understanding molecular changes in human brains with Alzheimer's disease: implications for microglia activation and sex differences
The utilization of artificial intelligence in studying the dysregulation of gene expression in Alzheimer's disease (AD) affected brain tissues remains underexplored, particularly in delineating common and specific transcriptomic signatures across different brain regions implicated in AD-related cellular and molecular processes, which could help illuminate novel disease biology for biomarker and target discovery. Herein we developed a deep learning framework, which consisted of multi-layer...
Tau PET positivity in individuals with and without cognitive impairment varies with age, amyloid-β status, APOE genotype and sex
Tau positron emission tomography (PET) imaging allows in vivo detection of tau proteinopathy in Alzheimer's disease, which is associated with neurodegeneration and cognitive decline. Understanding how demographic, clinical and genetic factors relate to tau PET positivity will facilitate its use for clinical practice and research. Here we conducted an analysis of 42 cohorts worldwide (N = 12,048), including 7,394 cognitively unimpaired (CU) participants, 2,177 participants with mild cognitive...
Inactivation of Histone Chaperone HIRA Unmasks a Link Between Normal Embryonic Development of Melanoblasts and Maintenance of Adult Melanocyte Stem Cells
Evidence indicates that the integrity of in utero development influences late life healthy or unhealthy aging; however, specific links between them are unclear. Histone chaperone HIRA is thought to play a role in both life stages, and here, we explore this role using the murine pigmentary system by investigating and comparing the effects of its lineage-specific knockout, either conditionally during embryogenesis or postnatally. Embryonic knockout of Hira in tyrosinase+ neural crest-derived...