Aggregator
Development and characterization of experimental beta-cell senescence models revealing autophagy defects and altered stimulus-secretion coupling
Aging is a major contributor to β-cell dysfunction in type 2 diabetes, with cellular senescence increasingly recognized as an important underlying mechanism. Here, we established a doxorubicin (DOX)-induced senescence model using MIN6 mouse insulinoma β-cell line to elucidate the mechanisms by which senescence remodels organelle homeostasis and insulin secretion. Senescence was validated by senescence-associated β-galactosidase positivity, p16^(INK4a)/p21/p53 upregulation, and cell cycle arrest....
Daily multivitamin slows signs of biological ageing
No abstract
How bumble bees survive days underwater without drowning
Insects can stay alive for up to a week in flooded nests, thanks to several tricks