Aggregator

CONCLUSIONS: Frailty assessed using the mFI-11 was not independently associated with IOH occurrence in older adults undergoing hip fracture surgery. However, frail patients tended to experience a longer cumulative duration of IOH once it developed, suggesting a possible link between frailty and the persistence rather than the occurrence of intraoperative hemodynamic instability. These findings highlight the importance of vigilant intraoperative hemodynamic monitoring and individualized...

CONCLUSIONS: Culturally specific early-life adversity patterns, particularly household dysfunction and pervasive adversity, predict adverse successful aging trajectories. These childhood patterns are associated with a more rigid late-life mind-body network characterized by tight pathological coupling between cognition and physical illness. Importantly, broader structural inequalities across the life course, particularly low educational attainment and rural residence, operate alongside early-life...

CONCLUSIONS: Interventions with similar short-term clinical outcomes may differ substantially in their economic and population health value. Within the short-term trial horizon, lifestyle-based strategies were associated with more favorable cost-utility profiles. These findings should be interpreted as exploratory and should not be extrapolated to long-term comparative effectiveness, particularly given the established long-term cardiovascular and renal benefits of SGLT2 inhibitors that could not...

CONCLUSIONS: Comorbidities were consistently associated with poorer survival outcomes among older adults with cancer. International and Japanese studies appeared to emphasize different mechanisms linking comorbidities to prognosis; however, these differences should be interpreted cautiously owing to heterogeneity in study design, outcome definitions, and data sources. Further large-scale studies incorporating standardized comorbidity assessment are needed to clarify the mechanisms through which...

BACKGROUND: Dementia prevention is an urgent global health priority in aging populations. Mild cognitive impairment (MCI) presents a key window for intervention, where cognitive training can effectively slow progression to dementia. There remains a need for implementation strategies that activate primary healthcare providers (the first point of contact) to deliver such interventions. This study aims to evaluate a multi‑component implementation strategy (enhanced training, financial incentives,...

A new Penn State study suggests that just four minutes of daily strength training can significantly improve mobility and physical function in older adults. After 12 weeks, participants showed meaningful gains in balance, leg strength, and their ability to stand up from a chair, all important factors for maintaining independence and reducing fall risk.