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Graduate-student stipends in Canada below the poverty line
How quantum mechanics emerged in a few revolutionary months 100 years ago
What will viruses do next? AI is helping scientists predict their evolution
Recollection-related fMRI effects in entorhinal cortex predict longitudinal memory change in healthy older adults
The present study examines whether structural and functional variability in medial temporal lobe (MTL) neocortical regions correlate with individual differences in episodic memory and longitudinal memory change in cognitively healthy older adults. To address this question, older adults were administered a battery of neuropsychological tests on three occasions: the second occasion one month after the first test session, and a third session three years later. Structural and functional MRI data...
Lineage tracing senescence in vivo shows not all senescent cells are created equal
Understanding the impact of senescence on disease is limited by the lack of tools to lineage label senescent cells. In a recent Cell issue, Zhao et al. create mouse models to genetically manipulate and trace p16^(+) cells, identifying contrasting roles for senescent macrophages and endothelial cells (ECs) in liver fibrosis.
Age-associated interplay between zinc deficiency and Golgi stress hinders microtubule-dependent cellular signaling and epigenetic control
Golgi abnormalities have been linked to aging and age-related diseases, yet the underlying causes and functional consequences remain poorly understood. This study identifies the interaction between age-associated zinc deficiency and Golgi stress as a critical factor in cellular aging. Senescent Golgi bodies from human fibroblasts show a fragmented Golgi structure, associated with a decreased interaction of the zinc-dependent Golgi-stacking protein complex Golgin45-GRASP55. Golgi stress is...
Association between weight-adjusted-waist index and serum anti-aging protein alpha-Klotho in U.S. adults: Evidence from NHANES 2007-2016
CONCLUSIONS: To sum up, weight-adjusted-waist index levels were negatively associated with serum Klotho protein concentration and showed a stronger correlation than other obesity markers. Our findings indicated that WWI may be a predictor of reduced Klotho levels, and that controlling obesity in accordance with WWI may help lower the Klotho levels.
Daily briefing: Why did Europe’s first cities disappear? Uncovering the mysterious Cucuteni–Trypillia culture
NASA still has no plan for how to bring precious Mars rocks to Earth
Particle accelerators get an assist from AI co-pilots
Who built Europe’s first cities? Clues about the urban revolution emerge
The structure of bad cholesterol comes into focus
What do people eat and why do they eat it?
Researchers: concentrate on bread-and-butter issues to get political buy-in
Biodiversity credits are more problematic than carbon credits
Science communication has a problem — communication
To ensure trust, AI weather-forecast models still need training in physics
NASA punts decision on Mars sample return to next administration
Two options both promise to trim billions from mission’s cost
As academic Bluesky grows, researchers find strengths—and shortcomings
Platform fosters collegial interactions among scientists, but potentially limits interactions beyond the academic community
Nonreceptor tyrosine kinase ABL1 regulates lysosomal acidification by phosphorylating the ATP6V1B2 subunit of the vacuolar-type H<sup>+</sup>-ATPase
The vacuolar-type H^(+)-ATPase (V-ATPase) is a proton pump responsible for controlling the intracellular and extracellular pH of cells. Its activity and assembly are tightly controlled by multiple pathways, of which phosphorylation-mediated regulation is poorly understood. In this report, we show that in response to starvation stimuli, the nonreceptor tyrosine kinase ABL1 directly interacts with ATP6V1B2, a subunit of the V(1) domain of the V-ATPase, and phosphorylates ATP6V1B2 at Y68. Y68...