Nature Aging
Repurposing drugs for the prevention of vascular dementia using evidence from drug target Mendelian randomization
p21<sup>+</sup>TREM2<sup>+</sup> senescent macrophages fuel inflammaging and metabolic dysfunction-associated steatotic liver disease
Astrocyte-based CAR immunotherapy against Alzheimer’s disease
Exoproteome of calorie-restricted humans identifies complement deactivation as an immunometabolic checkpoint reducing inflammaging
Single-cell analysis of the human immune system reveals sex-specific dynamics of immunosenescence
Biological sex shapes divergent trajectories of immune aging
Extracellular vesicles derived from senescent hepatocytes drive pan-cancer metastasis in aging
Neuronal APOE4-induced early hippocampal network hyperexcitability in Alzheimer’s disease pathogenesis
The case for space as a model of accelerated aging
Stem cell therapy might improve aging frailty
Multiomic single-cell perturbation screens reveal critical lncRNA regulators of senescence
Single-cell spatial atlas of the aging human breast
Cellular and spatial remodeling of aging breast tissue revealed
Subcellular orchestration of microglial aging
Spontaneous aging-associated inflammation and genome instability in the immune system of turquoise killifish
Longitudinal changes in epigenetic clocks predict long-term mortality
Longitudinal changes in epigenetic clocks predict survival in the InCHIANTI cohort
Microglia protein profiles in CSF across Alzheimer’s disease clinical stages
Microfluidics device recovers oocytes for IVF
Simultaneous spatial transcriptomics and morphology profiling as tools to explore how microglia change with age
How long will we live? And how much of that time will comprise a healthy life? What is aging, and can we stop or even reverse the aging process? What is the connection between aging and disease? Can we predict the evolving trends in the aging of human populations and prepare our societies for what has been called the Silver Tsunami? These are some of the important questions that the broad field of aging research is trying to address and that together form one of the Grand Challenges of the twenty-first century. The mission of Nature Aging is to provide a unique multidisciplinary, unifying and highly visible publishing platform for the aging-research community. The journal is highly selective yet broad in its coverage, publishing research from across the entire spectrum of the field, ranging from the basic biology of aging to the impact of aging on society. The journal aims to foster interactions among different areas of this diverse field of research and to promote new and exciting ideas within and beyond the research community, to enable synergy and maximize scientific and societal impact.
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