Aging & Longevity
Acceleration of Lactate Uptake and Utilization Contributes to Neuroprotective Action of FGF21 Involved in Naturally Aging Mice
Brain aging is characterized by neuroinflammation and lactate metabolic changes. However, the functional role of FGF21 in the aging brain and its influence on lactate homeostasis remains unclear until now. In the study, male C57BL/6 mice were divided into 2-month-old (control), 20-month (aging), and FGF21-treated aging mice (FGF21). We also examined the MAPK signals and astrocyte-neuron lactate shuttle (ANLS) proteins in wild-type and hydroxycarboxylic acid receptor 1-knockout (HCA1-KO) mice...
Epigenetic Clocks of Biological Aging and Risk of Incident Mild Cognitive Impairment and Dementia: The Women's Health Initiative Memory Study
Aging is the strongest risk factor for dementia; however, few studies have examined the association of biological aging with incident dementia. We analyzed 6069 cognitively unimpaired women (mean age = 70.0 ± 3.8 years) in the Women's Health Initiative Memory Study to examine the association of accelerated biological aging, measured with second and third-generation epigenetic clocks (AgeAccelPheno and AgeAccelGrim2, and DunedinPACE, respectively) with incident mild cognitive impairment (MCI) and...
Age-dependent effects of fibroblast-derived exosomes on keratinocyte differentiation
Skin aging is driven by both extrinsic factors, such as ultraviolet exposure, and intrinsic, chronological processes that lead to progressive deterioration in skin homeostasis and structure. Chronological aging is associated with replicative senescence and a range of molecular and cellular alterations, including genomic instability, mitochondrial dysfunction, and impaired intercellular communication. The dynamic cross-talk between dermal fibroblasts and epidermal keratinocytes is crucial for...
"Metabolic memory" of aging: anchoring, transmission, and frontiers of transgenerational intervention
Cellular senescence is the core cytological basis for organismal aging and the development of age-related diseases. Accumulating evidence indicates that senescent phenotypes can be maintained long-term even after the removal of senescence-inducing stressors, and may even affect daughter cells and offspring. This review systematically proposes an integrated theoretical framework of "aging metabolic memory", explaining the persistence, transmissibility, and potential heritability of aging from a...
Functional fibrinolysis in older adults: clinical relevance and implications for personalised anticoagulation
Age-related alterations of the haemostatic system substantially contribute to the heightened thrombotic and bleeding risk observed in older adults. While age-associated changes in coagulation have been extensively characterised, impairment of fibrinolysis remains comparatively underexplored, particularly in the context of anticoagulation management. Ageing promotes a hypofibrinolytic milieu through endothelial dysfunction, chronic low-grade inflammation, cellular senescence, and structural...
Insolubilome profiling defines molecular features that influence protein insolubility with aging
Solubility regulates protein function, but how it is governed by aging remains elusive. Here, we utilized mass spectrometry to define the relative composition of the soluble and insoluble tissue/organ fractions during mouse aging. In the young, there is a wide (∼100-1,000×) range of insoluble/soluble protein ratios that differ tissue-specifically. With aging, some proteins become relatively more insoluble, while others are conversely regulated or unaffected. Age-related insoluble/soluble changes...
Periodontal Disease as a Marker of Malnutrition Risk in Community-Dwelling Older Adults
CONCLUSIONS AND IMPLICATIONS: The present findings supported integrating oral health evaluation into nutritional screening in older age and geriatric comprehensive assessment, highlighting the need for interdisciplinary strategies to promote healthy aging.
Characterization of EEG power spectrum correlates of standing and walking in older adults: A scoping review
CONCLUSION: Knowledge synthesized in this review provides insight into the neurobiological mechanisms underlying standing and walking in older adults. The findings of this scoping may lead to developing personalized interventions, such as using non-intensive brain stimulation, to target certain brain activity, which might eventually reduce the risk of falls and disability among older adults.
The turquoise killifish (Nothobranchius furzeri) as emerging ageing model: Systematic review and comparison with zebrafish, medaka and Fugu
Selecting the most appropriate model organisms is crucial for studying ageing and ageing-related diseases. While vertebrate aging models offer valuable research feasibility due to their biological complexity and human relevance, their inherent lifespan limitations and high costs significantly restrict their experimental utility. The turquoise killifish (Nothobranchius furzeri, N. furzeri) is a relatively new animal model with the shortest lifespan among vertebrate models. We conducted a...
Veteran and Provider Perspectives on Rehabilitation for Severe Hearing Loss
CONCLUSION: Although hearing care is available to Veterans, multi-level factors influence the delivery of hearing care and management for Veterans with severe hearing loss. Greater attention both in primary and specialty care is needed to ensure tailored treatments are available to Veterans with severe hearing loss across the integrated VA health care system.
Genetic modifiers of APOE-ε4-associated cognitive decline
The APOE-ε4 allele is the strongest genetic risk factor for late-onset Alzheimer's disease. However, APOE-ε4 is not deterministic, highlighting the need to identify additional genetic and environmental factors. APOE-ε4 has been linked to accelerated cognitive decline, so we sought to investigate genetic factors that modify APOE-ε4-associated cognitive decline. We conduct cross-ancestry APOE-ε4-stratified and interaction GWAS using harmonized cognitive data from 32,778 participants, including...
Epigenetic profiling of hematopoietic stem cells from male mice identifies KDR and PU.1 as regulators of aging transcriptome and caloric restriction response
Caloric restriction (CR) provides anti-aging benefits but has also been reported to be associated with reduced immune function, and how hematopoietic stem cells (HSCs) potentially contribute to this decline remains unclear. Using lifelong and short-term CR in male mice, we found reducing the energy supply decreases total white blood cell production and shifts hematopoiesis towards myeloid and thrombo-erythroid lineages, prioritizing cells essential for survival (red blood cells, platelets,...
Variants in MTNAP1 underlie a neurodegenerative disorder by impairing mitochondrial stability
Mutations in genes encoding mitochondrial proteins are increasingly recognized as a major cause of neurodegenerative disorders, owing to the role of mitochondria in neuronal energy metabolism and signaling. Here, we investigate MTNAP1 (mitochondrial nucleoid-associated protein 1) as a novel gene associated with an autosomal recessive neurodevelopmental disorder characterized by progressive cerebral and cerebellar atrophy. Three affected probands from two unrelated families presented with global...
Daily briefing: What we know about autism and ageing - and what we don't
No abstract
Plasma-based strategies for systemic rejuvenation: critical perspectives on clinical translation
Experimental models such as heterochronic parabiosis and heterochronic plasma transfer have profoundly advanced our understanding of systemic aging, demonstrating that circulating factors can influence brain, vascular, and immune aging through cell nonautonomous mechanisms. These preclinical models have revealed that both pro-geronic and anti-geronic signals in blood can modulate neuroinflammation, neurovascular health, and cognitive resilience. However, despite their experimental promise, the...
Transcriptomic and chromatin accessibility profiling unveils new regulators of heat hormesis in Caenorhabditis elegans
Heat hormesis describes the beneficial adaptations resulting from transient exposure to mild heat stress, which enhances stress resilience and promotes healthy aging. While heat hormesis is widely observed, much remains to be learned about its molecular basis. This study bridges a critical knowledge gap through a comprehensive multiomic analysis, providing key insights into the transcriptomic and chromatin accessibility landscapes throughout a heat hormesis regimen in Caenorhabditis elegans. We...
Aging-associated differences in mammary tumor-initiating populations and immune evasion pathways in breast cancer
Aging is a major risk factor for breast cancer, yet how it shapes tumor development, molecular phenotype, and immune evasion remains incompletely understood. Deciphering how aging influences cancer evolution is critical for improving risk assessment, prevention, and treatment. Here, using a N-nitroso-N-methylurea (NMU)-induced rat mammary tumor model that recapitulates key features of human breast cancer, we integrated bulk and single-cell transcriptomics, whole-exome sequencing, and...
The relationship between physical activity participation and prosocial behavior among older adults: the mediating role of empathy
No abstract
Relationship Between Weight, Muscle Mass, Cardiorespiratory Endurance, and Likelihood of Dynapenia in Older Adults
CONCLUSIONS: Controlling body weight and encouraging older adults to engage in physical activities that enhance handgrip strength can reduce the risk of dynapenia. Therefore, promoting self-care behaviors to reduce the adverse outcomes of dynapenia is crucial for enhancing healthy life in older populations.
SK channel upregulation and sex-specific mechanisms drive spinal motoneuron reduced excitability with age
INTRODUCTION: Mechanisms underlying age-related weakness are not fully understood, with neuronal mechanisms recently gaining attention. Despite studies on excitatory and inhibitory inputs, conflicting findings on α-motoneuron intrinsic excitability and PIC changes highlight a major gap in explaining age-related strength decline.
Aging and Longevity: Latest results from PubMed
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