Aging & Longevity

CONCLUSION: Through integrated transcriptomic analysis together with in vitro experimental validation, this study indicates that TMEM140 may be a candidate bridge molecule connecting PD and AD comorbidity. TMEM140 may participate in shaping the peripheral-central immunosenescence network and contribute to the cross-system transmission of inflammatory signaling.

Aging involves morphological and functional changes across different organs, but how these changes are linked among the different organs remains to be elucidated. Here, we uncover a central role of platelets in systemic aging. In aged mice, the levels of platelet-secreted pro-inflammatory factors (PSPF) increased greatly in the serum and platelets, leading to a diffuse increase of platelet infiltration in the brain, liver, lung, kidney, and aortic root. The RNA-binding protein HuR/ELAVL1, a...

Deoxyribonucleic acid provides unmatched information density and longevity for data storage, yet its easy amplification by polymerase chain reaction enables unauthorized replication at negligible cost. We introduce ZAT-DNA, which encodes information in patterns of canonical adenine and noncanonical 2-aminoadenine. As DNA polymerases cannot distinguish adenine from 2-aminoadenine, polymerase-based amplification erases these patterns, enforcing molecular-layer non-replicability intrinsic to the...

By eliciting lung necrosis, which enhances aerosol transmission, Mycobacterium tuberculosis (Mtb) sustains its long-term survival as a human pathogen. In studying the human-like necrotic granuloma lesions characteristic of Mtb-infected B6.Sst1S mice, we found that lung myeloid cells display elevated senescence markers: cell cycle arrest proteins p21 and p16, the DNA damage marker γH2A.X, senescence-associated β-galactosidase activity, and senescence-associated secretory phenotype (SASP). These...

Metabolism unfolds within specific organelles in eukaryotic cells. Lysosomes are highly metabolically active organelles, and their metabolic states dynamically influence signal transduction, cellular homeostasis and organismal physiopathology. Despite the importance of lysosomal metabolism, a method for its in vivo measurement is currently lacking. Here we report a fluorescence-detected mid-infrared photothermal microscope (FILM) implemented with optical boxcar demodulation, artificial...

CONCLUSION: The DoMAP model provides a structured framework for capturing the diverse etiologies of malnutrition in older patients. This study emphasizes the multifactorial nature of malnutrition in hospitalized patients, with low intake and poor appetite emerging as predominant drivers.

Recent advances in van der Waals materials have sparked renewed interest in the impact of dimensionality on magnetic phase transitions. Although ordered magnetic phases have been demonstrated to survive in the two-dimensional (2D) limit, the quest for a spin glass with quenched magnetic disorder in lower dimensions has proven elusive. Here, we provide evidence of a spin glass emerging from randomly distributed Fe atoms in Fe(3)GeTe(2) (FGT). ac magnetic susceptibility displays a strong frequency...

Aging researchers and the removal of retirement policies yield decreased disruptive innovation in science.

CONCLUSION: In healthy older adults, adherence to a healthy lifestyle was associated with a greater likelihood of surviving free from disability and dementia and was prospectively linked with a prolonged healthspan and a compression of morbidity, highlighting its potential importance in promoting healthy aging.

Cellular senescence arises through replicative exhaustion or acute stress, yet whether these distinct triggers share a reproducible transcriptional organization has remained unresolved. Seven public human fibroblast RNA-seq datasets were integrated across both trigger types, moving from differential expression through Gene Ontology and Reactome enrichment to protein-protein interaction network embedding within a single harmonized framework. Both triggers converged on concordant repression of...

A recent study by Bieri et al. shows that exercise elevates hepatic glycosylphosphatidylinositol-specific phospholipase D1 (GPLD1), which cleaves endothelial tissue-nonspecific alkaline phosphatase (TNAP) to rejuvenate cerebrovascular signaling, enhance cognition in aging, and attenuate Alzheimer's-related pathology. This liver-to-brain enzymatic axis positions hepatokines as potent mediators of exercise-induced neuroprotection, which redefines systemic metabolism as a driver of brain...

The Six1 (SIX homeobox 1) gene is pivotal in renal and pulmonary development and differentiation. Its dysregulation is implicated in oncogenesis and tumor progression via enhancing cell proliferation and delaying senescence. However, whether or how it functions in the natural aging have not been investigated. To answer this question, we generated Six1 gene knockout mice using CRISPR-Cas9 technology. All Six1 biallelic knockout mice died at birth since the underdeveloped lungs. In Six1^(+/-)...

The aging process exhibits tissue-specific characteristics, yet its underlying mechanisms remain poorly understood. While it is widely accepted that a reduction in blood vessels in hard tissues contributes to aging, such as in osteoporosis, the vascular changes driving soft tissue aging and degeneration remain unclear. Here, by integrating single-cell transcriptomics and light-sheet imaging, we uncover a striking infiltration of type H-like blood vessels and an aging-specific Coch^(+) cell...

Developing sustainable adhesives with simultaneous high adhesive strength and excellent work of debonding remains challenging. Here, strong, ultra-tough, environmentally reliable, and recyclable polyurethane adhesives are reported, utilizing a multiscale engineering approach. The multiscale structure employs a top-down design philosophy to merge the advantages of both thermoplastic and thermosetting systems, integrating multi-level organizations including macroscale dual-length dynamic...

Red pulp macrophages (RPMs) remove senescent erythrocytes from the circulation and recycle their iron for erythropoiesis. The development of RPMs is guided by signals from the microenvironment, which promote expansion and tissue adaptation through the induction of transcription factors, including Spi-C and PPARγ. Here, we show that infection with the nematode Nippostrongylus brasiliensis or treatment with IL-33 results in the accumulation of activated group 2 innate lymphocytes (ILC2s) in the...

Background Pain is highly prevalent in older adults and linked to hyperacusis, yet evidence on its relationship with self-reported hearing difficulty (HD) remains limited. The aim of this study was to investigate the associations of pain with incident HD. Methods Adults aged ≥50 from six nationally-representative aging cohorts were included: the Health and Retirement Study (HRS), the English Longitudinal Study of Ageing (ELSA), the Survey of Health, Ageing and Retirement in Europe (SHARE), the...

The extended stay-green trait is beneficial to increase photosynthetic efficiency, thereby enhancing crop yield. However, factors and mechanisms affecting this process remain largely unknown. Here, we cloned a leaf precocious senescence gene (lps1-1) and created additional null alleles. All lps1 mutants exhibited accelerated leaf senescence with reduced chlorophyll contents and photosynthetic efficiency. The 100-kernel weight and storage reserve content were decreased in lps1 kernels, while the...

Over the past decade, clonal hematopoiesis (CH) has gained substantial attention as a prevalent, age-associated phenomenon with major implications for hematologic malignancy, cardiovascular disease, and mortality. CH arises from the clonal expansion of hematopoietic stem cells and progenitor cells harboring somatic mutations, most commonly in genes implicated in leukemia. Beyond chronological aging, CH evolution is shaped by lifelong exposure to inflammatory, metabolic, and environmental...

From a cellular perspective, senescence has been considered a binary state, wherein cells are either senescent or not. This reductionist notion, often defined as irreversible growth arrest, has guided efforts to identify universal biomarkers and senolytics, but both have consistently eluded us. This outcome is not surprising, given that the biological nature of senescence may not be strictly irreversible; the accumulated evidence suggests that growth arrest can become unstable over time, with...

Aging is a complex biological process characterized by progressive functional decline and increased risk of chronic diseases. In recent years, DNA methylation-based epigenetic clocks have emerged as some of the most robust biomarkers for estimating biological age. Initial research clocks, such as those developed by Horvath and Hannum, provided highly accurate chronological age predictions. Subsequent models, including PhenoAge, GrimAge, and DunedinPACE, improved upon this by incorporating...