Aging & Longevity
Corrigendum to "Assessment of muscle function deterioration in aging populations: Insights from the load-velocity relationship during the loaded sit-to-stand test" [Exp. Gerontol. 206 (2025) 112767]
No abstract
Early-life exercise extends healthspan but not lifespan in mice
It is well-known that physical activity exerts health benefits, yet the potential impacts of early-life regular exercise on later-life health and lifespan remains poorly understood. Here, we demonstrate that 3 months of early-life exercise in mice results in lasting health benefits, extending healthspan, but not lifespan. C57BL/6J mice underwent swimming exercise from 1 to 4 months of age, followed by detraining for the remainder of their lives. While early-life exercise did not extend the...
Aging-associated alterations in gene regulatory networks associate with risk, prognosis and response to therapy in lung adenocarcinoma
Aging is the primary risk factor for many cancer types, including lung adenocarcinoma (LUAD). To understand how aging-related alterations in the regulation of key cellular processes might affect LUAD risk and survival, we built individual-specific gene regulatory networks integrating gene expression, transcription factor protein-protein interaction, and sequence motif data, using PANDA/LIONESS algorithms, for non-cancerous lung samples from GTEx project and LUAD samples from TCGA. In healthy...
Selective remodelling of the adipose niche in obesity and weight loss
Weight loss significantly improves metabolic and cardiovascular health in people with obesity^(1-3). The remodelling of adipose tissue (AT) is central to these varied and important clinical effects⁴. However, surprisingly little is known about the underlying mechanisms, presenting a barrier to treatment advances. Here we report a spatially resolved single-nucleus atlas (comprising 171,247 cells from 70 people) investigating the cell types, molecular events and regulatory factors that reshape...
Coenzyme Q headgroup intermediates can ameliorate a mitochondrial encephalopathy
Decreased brain levels of coenzyme Q(10) (CoQ(10)), an endogenously synthesized lipophilic antioxidant^(1,2), underpin encephalopathy in primary CoQ(10) deficiencies^(3,4) and are associated with common neurodegenerative diseases and the ageing process^(5,6). CoQ(10) supplementation does not increase CoQ(10) pools in the brain or in other tissues. The recent discovery of the mammalian CoQ(10) headgroup synthesis pathway, in which 4-hydroxyphenylpyruvate dioxygenase-like protein (HPDL) makes...
Plasma proteomics links brain and immune system aging with healthspan and longevity
Plasma proteins derived from specific organs can estimate organ age and mortality, but their sensitivity to environmental factors and their robustness in forecasting onset of organ diseases and mortality remain unclear. To address this gap, we estimate the biological age of 11 organs using plasma proteomics data (2,916 proteins) from 44,498 individuals in the UK Biobank. Organ age estimates were sensitive to lifestyle factors and medications and were associated with future onset (within 17...
Mitochondrial dysfunction and aging: multidimensional mechanisms and therapeutic strategies
Aging is an inherent phenomenon that is highly important in the pathological development of numerous diseases. Aging is a multidimensional phenomenon characterized by the progressive impairment of various cellular structures and organelle functions. The basis of human organ senescence is cellular senescence. Currently, with the increase in human life expectancy and the increasing proportion of the elderly population, the economic burden of diseases related to aging is becoming increasingly heavy...
A mechanistic basis of fast myofiber vulnerability to neuromuscular diseases
Neuromuscular diseases such as amyotrophic lateral sclerosis and sarcopenia cause muscle atrophy, which preferentially affects fast-twitch glycolytic myofibers. The mechanisms underlying the susceptibility of fast myofibers to disease remain unclear. To investigate this, we analyzed the transcriptional profiles of myonuclei from denervated muscle fibers. We found that the fast muscle gene program and the transcription factor Maf were repressed upon denervation. Overexpression of Maf in mice...
Transcriptional Diversity in Response to Aging Across Skeletal Muscles
Aging leads to a gradual decline in muscle function, yet the mechanisms by which different skeletal muscles respond to aging remain unclear. Here, we constructed transcriptional maps of 11 skeletal muscles with extensive transcriptional diversity from young and old mice. Age-related changes in gene expression displayed distinct tissue-specific patterns, involving muscle diseases and metabolic processes. Notably, the mitochondrial-enriched soleus muscle exhibited superior resistance to aging...
The hidden economic burden of cancer caring
CONCLUSION: The time spent caring for people living with cancer by informal carers is significant. Recognizing and rigorously investigating the role of informal cancer carers in reducing the burden on the formal care sector and improving the quality of life of people living with cancer is essential to understanding the impact and significance of caring, which will facilitate impactful policy changes.
Neuroimmunology in ageing and longevity: a special collection issue of Biogerontology
Ageing is associated with neuroimmune shifts from a resting to a hyperactive and inflammatory state, termed 'Neuroinflammageing', attributed to microglial priming, hyperactive astrocytes, cytokine and chemokine release, blood brain barrier leakage, and infiltration of peripheral immune cells. This special issue of Biogerontology on 'Neuroimmunology in Ageing and Longevity' brings together 11 reviews and original research papers dealing with the complex cross-talk between CNS and peripheral...
Incentives and practice improve prospective memory performance in older adults
No abstract
Correction for Zhu et al., Population size interacts with reproductive longevity to shape the germline mutation rate
No abstract
Cognitive function changes and DTI-ALPS index in postmenopausal women
CONCLUSIONS: Reduced brain lymphatic function (lower ALPS index) is associated with cognitive decline in postmenopausal women, and this relationship is mediated by estrogen levels. The DTI-ALPS index may serve as a novel biomarker for menopause-related cognitive health.
Unveiling aging heterogeneities in human dermal fibroblasts via nanosensor chemical cytometry
Aging heterogeneity in tissue-regenerative cells leads to variable therapeutic outcomes, complicating quality control and clinical predictability. Conventional analytical methods relying on labeling or cell lysis are destructive and incompatible with downstream therapeutic applications. Here we show a label-free, nondestructive single-cell analysis platform based on nanosensor chemical cytometry (NCC), integrated with automated hardware and deep learning. nIR fluorescent single-walled carbon...
Psilocybin treatment extends cellular lifespan and improves survival of aged mice
Psilocybin, the naturally occurring psychedelic compound produced by hallucinogenic mushrooms, has received attention due to considerable clinical evidence for its therapeutic potential to treat various psychiatric and neurodegenerative indications. However, the underlying molecular mechanisms remain enigmatic, and few studies have explored its systemic impacts. We provide the first experimental evidence that psilocin (the active metabolite of psilocybin) treatment extends cellular lifespan and...
Escaping ageing through Cell Annealing-a phenomenological model
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Stress is wrecking your health: how can science help?
No abstract
Bibliometric insights into the cell cycle, aging, and metabolism: from molecular mechanisms to clinical implications
Cell cycle regulation, aging, and metabolism are pivotal biological processes linked to both normal physiology and disease development. Understanding their interplay is crucial for advancing gerontological research and clinical oncology. We analyzed articles and reviews on the cell cycle, aging, and metabolism from 2004 to 2023 using the Web of Science Core Collection. Bibliometric tools, VOSviewer, and CiteSpace, were applied to visualize collaboration networks, geographic distributions, and...
Pathways to change in existential group treatment: experiences from older adults with psychological distress in primary care
CONCLUSIONS: Older adults' experiences of existential group treatment suggest that engaging in existential dimensions of aging can be helpful when done in a structured setting together with others. Reduced experiential avoidance, increased determination to do what feels meaningful, relational aspects as well as one's own commitment to therapy can help explain how existential group treatment may contribute to change among older adults with psychological distress.
Aging and Longevity: Latest results from PubMed
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