Aging & Longevity

Cellular senescence is a fundamental biological process contributing to aging, often accompanied by extensive chromatin remodeling. Dynamic alterations of three-dimensional (3D) genomic spatial structure, driven by chromatin reorganization, play a critical role in cell fate determination, but their relevance in therapy-induced senescence (TIS) remains underexplored. Here, we perform an integrative multi-omics analysis of Hi-C, ATAC-seq, CUT&RUN, and RNA-seq in primary human fibroblasts...

Chronic stress has been linked to mitochondrial dysfunction and impaired telomere maintenance, yet the mechanistic relationships connecting these pathways in humans remain poorly resolved. Using longitudinal findings from the Guillén-Parra cohort as a motivating human example, this Perspective offers a reinterpreted framework that proposes a unifying energetic interpretation in which bioenergetic insufficiency-defined as a mismatch between stress-induced energetic demand and mitochondrial...

Reprogramming of somatic cells into induced pluripotent stem cells through the introduction of transcription factors Oct3/4, Sox2, Klf4, and c-Myc (OSKM) represents a landmark advance in regenerative biology. Building on this foundation, partial reprogramming can help reset epigenetic age. It further opens opportunities to treat degenerative diseases without the tumorigenic risks associated with full pluripotency. The review advances the field in three ways: it links lineage-preserving partial...

CONCLUSIONS AND IMPLICATIONS: Our equation appears to have high predictive power. With rapid and simple measurement of anthropometric and demographic indices, the equation can be used to evaluate ASM in primary care facilities lacking specialized equipment.

The Greenland shark (Somniosus microcephalus) is the longest-living vertebrate and inhabits the exceptionally dim and cold waters of the Arctic deep sea. Due to its extreme lifespan, harsh environmental conditions, and prevalent corneal parasitisation, the Greenland shark has previously been thought to have impaired or degenerated vision. Here, we present genomic, transcriptomic, histological and functional evidence that the Greenland shark retains an intact visual system well-adapted for life...

Resistance training (RT) is an effective intervention for improving muscle health and metabolism in ageing, but the degree of responsiveness (hypertrophy) to RT varies substantially. We examined muscle metabolomic profiles before and after 10-weeks RT in older adults classified into upper (UPPER) and lower (LOWER) tertiles of hypertrophy to identify key metabolic adaptation differences. Fifty older adults (23 males, 27 females, mean 68.2 years old) completed 10 weeks of RT combined with whey...

Clonal haematopoiesis of indeterminate potential (CHIP) is an ageing-related condition associated with a substantial fraction of circulating leukocytes having descended from a single somatically mutated haematopoietic stem cell (HSC). CHIP increases the risk of haematological malignancies and several chronic diseases (for example, cardiovascular pathologies) and contributes to persistent, low-grade inflammation or inflammageing. Inflammageing, in turn, promotes functional impairment of normal...

Brain health is closely linked to bone homeostasis. Skeletal aging is characterized by inadequate bone formation and marrow adiposity, but whether the brain contributes to this imbalance remains unknown. This study shows that aged brain neurons, mainly those in the hippocampus and cerebral cortex, produce excess WD repeat and FYVE domain containing 1 (WDFY1) protein and transfer it to the bone via extracellular vesicles (EVs), leading to bone-fat imbalance and osteoporosis. Increasing brain...

Replacing volatile methylammonium (MA^(+)) with formamidinium (FA^(+)) or cesium (Cs^(+)) cations in mixed Pb-Sn perovskite compositions improves thermal resilience. Nevertheless, the low-solubility Cs-based perovskite tends to preferentially crystallize into a dense Cs-rich surface layer during the AS-assisted crystallization process, which impedes the AS to extract the internal solvent. Here, we introduce a multi-Lewis-base modulator to maintain sustained solvent-extraction channels (SSC) open...

No abstract

Psycho-socio-economic factors (PSEFs) such as income and homeownership may influence the prevalence of cardiorenal multimorbidity (CRM), yet their prospective associations with CRM risk remain unclear. This study aimed to estimate CRM incidence and examine its relationships with multiple PSEFs in a nationally representative Canadian cohort. We analyzed data from 16,557 participants (mean age: 60.4 years; 48.9% men) in the Canadian Longitudinal Study on Aging (CLSA) who were free of CRM at...

No abstract

CONCLUSION: The study highlights the inequalities in the subjective physical and mental health of older adults across cities with different administrative hierarchies in China. By providing more resources, cities with higher administrative hierarchies can significantly improve older adults' life quality and subjective health. Meanwhile, marketization further strengthens the positive impact of urban administrative hierarchy on mental health. By introducing the urban administrative hierarchy as a...

Homologous recombination (HR) is traditionally portrayed as a DNA double-strand break repair pathway. However, emerging evidence positions RAD51, its partners BRCA1, BRCA2, and other HR factors at the core of a broader genome-maintenance network that operates by a "prevent and protect" strategy extending beyond repair. Here, we review how RAD51 can shield DNA from nucleolytic processing mediated by MRE11 and related nucleases, promote fork reversal, suppress replicative DNA gaps accumulation,...

CONCLUSION: The ACP training program has successfully engaged staff in care homes by increasing their capacity, opportunity, and motivation.

CONCLUSION: The findings elucidate a complex interplay between cardiovascular health and auditory function, emphasizing that heart attacks may exacerbate HL through the frailty pathway in certain older populations. These results highlight the need for tailored cardiovascular interventions and proactive measures to mitigate HL risks. Future research should focus on defining these pathophysiological associations more clearly to develop targeted interventions for vulnerable older people.

CONCLUSION: Our findings highlight that maintaining physical activity, particularly during middle adulthood, is associated with reduced risk of sarcopenia. Because physical activity was self-reported, future research should employ objective measures and longitudinal designs to confirm these associations.

The mechanisms for failure of neoadjuvant immune checkpoint blockade (NICB), an established therapy for patients with esophageal squamous cell carcinoma (ESCC), remain unclear. We integrated single-cell RNA data from patients with ESCC pre- and post-NICB, identifying a subset of senescent EGR1-expressing B cells that correlate with poor pathological responses. EGR1 was a key transcription factor regulating B cell senescence. EGR1^(+) B cells emerged as predictors of adverse outcomes in multiple...

Rapid urbanization has driven widespread increases in artificial light at night, intensifying energy use, light pollution, and sustainability challenges. However, its ecological impacts, particularly on vegetation phenological transitions, remain poorly understood. Using 62,994 site-year in situ records and satellite observations across 452 cities from 2001 to 2022, we show that elevated levels of artificial light at night are associated with delayed dates of foliar senescence in urban areas....

Genotoxic drugs used to treat cancer can trigger senescence, which contributes to chemotherapy resistance and tumor heterogeneity. However, the resulting cellular and molecular alterations following senescence remain poorly characterized. In this study, chemotherapy-induced senescence was triggered by etoposide in MDA-MB-231 breast cancer cells, and their fibrogenic potential, epithelial-to-mesenchymal transition (EMT), and stemness features were examined. In these cells, key mediators of...