Aging & Longevity

In the low Reynolds number regime, active biological systems utilize nonreciprocal cyclic activities to achieve motility, as seen in the spinning of bacterial flagella and the beating of cilia. Coupling among these active mechanical components leads to synchronization and emergence of metachronal waves. Here, we report that biofilms of Pseudomonas nitroreducens form active carpet-like surfaces textured with diverse topological defects, generating Mexican-wave-like collective behavior in which...

Long-living individuals (LLIs) possess remarkable genetic resilience, characterized by protective variants that confer immune robustness and resistance to age-related diseases. The longevity-associated variant of BPIFB4 (LAV-BPIFB4), enriched in centenarians, demonstrated pleiotropic benefits including reduced inflammation, cardiovascular protection, and immune system rejuvenation. However, the molecular mechanisms underlying these protective effects remain incompletely understood. Here, we...

Renal aging shortens healthspan and propagates organ dysfunction beyond the kidney, yet its molecular drivers remain incompletely defined. Here we identify microsomal prostaglandin E synthase-2 (mPGES-2) as a critical regulator of renal aging and its skeletal consequence. Genetic ablation of Ptges2 improved health indices in aged mice, prolonged median survival, and markedly alleviated glomerulosclerosis, podocyte injury, and renal senescence. Single-cell transcriptomic analysis, together with...

Intrinsic capacity (IC), introduced by the World Health Organization, provides a multidimensional framework for evaluating functional aging across locomotion, cognition, sensory, psychological, and vitality domains. However, gut microbial features associated with IC among community-dwelling older adults remain incompletely understood. In this exploratory cross-sectional study, we enrolled 52 community-dwelling older adults and assessed gut microbiota using full-length 16S rRNA sequencing....

CONCLUSIONS: A multifaceted, system-wide prevention and care model may attenuate the upward trend in chronic-disease prevalence in highly aged populations. These findings support integrated health-promotion strategies as a sustainable approach to chronic disease management and resource stewardship.

Aging is characterized by progressive physiological decline and age-related pathologies, yet the molecular determinants underlying lineage- and species-specific aging traits remain poorly understood. Although protein-coding regulators have dominated aging research, the contribution of long non-coding RNAs (lncRNAs), particularly primate-specific lncRNAs, has not been systematically explored. Here, through evolutionary screening and cross-species aging-associated analyses, we identified a set of...

CONCLUSION: The described barriers contributed to fears of losing personal identity, daily habits, and (culturally) meaningful ways of being. The findings highlight the need for stakeholders and policymakers to address these vulnerabilities when developing healthcare and social services for immigrants living with dementia.

CONCLUSION: Our findings underscore the importance of minimizing unfinished care, as it is regarded as an indicator of quality, and is significantly associated with all dimensions of risk of burnout. Managerial support appears to act as a buffer in this association, with unfavorable support exacerbating the effects, particularly with regard to depersonalization. Conversely, these effects are attenuated when care workers perceive their manager as supportive, emphasizing the value of supportive...

Parkinson disease (PD) is closely linked to disruptions in mitochondrial quality control, a process regulated by the ubiquitin kinase PINK1 and the E3 ubiquitin ligase PRKN/parkin. Upon mitochondrial damage, PINK1 phosphorylates ubiquitin, which in turn recruits and activates PRKN. Full activation of PRKN is mediated by PINK1-dependent phosphorylation of PRKN at serine 65, which leads to widespread ubiquitination of mitochondrial substrates and amplifies the mitophagy response. Disruption of...

CONCLUSION: Aging is associated with simplified muscle synergies and strengthened coactivation, which helps preserve stability under cognitive load but elevates energetic cost. These findings demonstrate that cognitive interference strengthens the coupling between neuromuscular organization and energetic expenditure, identifying synergy entropy and dual-task energy cost as potential targets for monitoring and improving mobility in older adults.

Aging is frequently associated with a progressive loss of physiological integrity, with immunosenescence and chronic inflammation playing pivotal roles in this process. While natural compounds like Dihydromyricetin (DHM) exhibit significant anti-aging potential, its precise upstream immunomodulatory targets and cross-species conservation remain largely elusive. Through a combination of transcriptomic analyses and cross-species assays, we demonstrated that DHM systematically downregulates basal...

As the population ages, the issue of falls among the elderly is becoming increasingly prominent, and balance dysfunction is one of the main risk factors for falls. Accurately assessing balance function in older adults and elucidating its underlying neural mechanisms holds significant clinical importance for predicting fall risk and developing personalized interventions. In recent years, functional near-infrared spectroscopy (fNIRS), as a non-invasive brain imaging technology, has demonstrated...

Cardiovascular disease (CVD) remains a leading cause of morbidity and mortality worldwide. The ubiquitin proteasome system (UPS) is essential for maintaining intracellular protein homeostasis, and growing evidence indicates that its dysregulation critically contributes to the onset and progression of various CVDs, particularly in the context of aging. Among these, ubiquitin-specific proteases (USPs) have emerged as promising therapeutic targets, but their precise roles and regulatory mechanisms...

Clonal hematopoiesis of indeterminate potential (CHIP) describes the proliferation of blood cell clones that carry driver mutations, such as DNA methyltransferase 3 alpha (DNMT3A), ten-eleven translocation 2 (TET2), additional sex combs like 1 (ASXL1), and Janus kinase 2 (JAK2), without leading to any obvious malignancy. Its occurrence rate is age-related and associated with cardiovascular and immune aging. In prospective cohort studies, CHIP substantially elevated the risk of myocardial...

Magma convection is a mechanism that greatly enhances heat transfer from mobilizable, crystal-poor magma bodies to the surrounding immobile, crystal-rich mush reservoir of Earth's igneous systems. As most of these systems are geophysically shown to be mush-dominated, magma convection is often omitted from thermo-kinetic models, and its role in magma evolution and eruptibility remains underexplored. Here we present 2-D numerical thermal modelling that parameterizes magma convection through a...

Overcoming interfacial mechano-electrochemical failure remains a fundamental challenge in solid-state lithium metal batteries, where polymers offer conformal interfacial contact but suffer from low ionic conductivity, while oxides/sulfides provide high ionic conductivity but face severe interfacial issues. Here we show a mechano-integrated gradient electrolyte based on a hydrogen-bonded polyurethane matrix with dual chain extenders. The polyurethane matrix exhibits high viscoelasticity (>5000%...

Stimulator of interferon genes (STING) is an evolutionary conserved immune signalling protein with key roles in host defence, cancer, senescence and inflammation^(1-3). Downstream of STING, type I interferon, inflammatory cytokine signalling and non-canonical autophagy are governed by a multilayered mechanism integrating ligand-induced structural transitions, protein-protein interactions and coordinated intracellular trafficking^(4-13). Despite its central role in immunity and relevance as...

Hippocampal theta oscillations coordinate computations underlying learning and memory. The frequency of theta varies with factors such as locomotion and anxiety, but the effect of an animal's sleep history on theta frequency remains unknown. Using long-duration CA1 recordings in rats, we found that awake theta frequency progressively decreases following sleep but remains elevated during sleep deprivation. These changes were not accounted for by movement but were predicted by the proportion of...

The dynamics of stem cell maintenance and proliferative patterns are key determinants of tissue aging in multicellular organisms. Leveraging our previously developed SMALT system with enhanced sequencing compatibility, we performed longitudinal lineage tracing of the adult Drosophila melanogaster midgut across different developmental stages. Using ubiquitous Tubulin-GAL4-driven labeling, we first profiled midgut-wide clonal dynamics during early adulthood (3-33 days post-eclosion). Phylogenetic...

Mitochondrial stress activates nuclear transcriptional programs to restore homeostasis and promote longevity; yet, the nuclear effector that directly reshapes chromatin during stress remains unclear. Through a forward genetic screen in Caenorhabditis elegans, we identify FUBL-3, the homolog of human far-upstream elements binding protein 1 (FUBP1), as a conserved regulator that couples mitochondrial stress to chromatin remodeling. FUBL-3 translocates to intestinal nuclei upon stress, where it...