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Muscle-Specific Upregulation of Timeless Mediates Exercise-Induced Amelioration of Age-Related Circadian Rhythm Disruption and Cardiac Dysfunction in Drosophila
The core genes of the circadian pathway, such as Timeless(Tim), not only participate in the regulation of biological rhythms, but also play significant roles in DNA damage repair, chronic inflammation, and cellular metabolism. However, it remains unclear whether exercise can delay the age-related phenotypic degeneration by regulating the muscle Tim gene. In here, we first carried out the expression regulation of the muscle Tim gene in the Drosophila by constructing the Mhc-gal4/Tim-UAS system,...
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Early statin use linked to 15% lower dementia risk
Starting statins soon after a type 2 diabetes diagnosis may do more than protect the heart. In a nationwide Danish study of more than 132,000 people, those who began statin treatment within a year of diagnosis had a 15% lower relative risk of developing dementia over 10 years compared with those who did not start statins.
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Stereoselective polysubstituted bicyclo[1.1.0]butane synthesis by rhodium-catalyzed kinetic resolution
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