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The HEAT repeat protein HPO-27 is a lysosome fission factor

21 hours 33 minutes ago
Lysosomes are degradation and signalling centres crucial for homeostasis, development and ageing¹. To meet diverse cellular demands, lysosomes remodel their morphology and function through constant fusion and fission^(2,3). Little is known about the molecular basis of fission. Here we identify HPO-27, a conserved HEAT repeat protein, as a lysosome scission factor in Caenorhabditis elegans. Loss of HPO-27 impairs lysosome fission and leads to an excessive tubular network that ultimately...
Letao Li

Fructose-1,6-bisphosphatase 1 dephosphorylates and inhibits TERT for tumor suppression

21 hours 33 minutes ago
Telomere dysfunction is intricately linked to the aging process and stands out as a prominent cancer hallmark. Here we demonstrate that telomerase activity is differentially regulated in cancer and normal cells depending on the expression status of fructose-1,6-bisphosphatase 1 (FBP1). In FBP1-expressing cells, FBP1 directly interacts with and dephosphorylates telomerase reverse transcriptase (TERT) at Ser227. Dephosphorylated TERT fails to translocate into the nucleus, leading to the inhibition...
Min Li

TREM1 disrupts myeloid bioenergetics and cognitive function in aging and Alzheimer disease mouse models

21 hours 33 minutes ago
Human genetics implicate defective myeloid responses in the development of late-onset Alzheimer disease. A decline in peripheral and brain myeloid metabolism, triggering maladaptive immune responses, is a feature of aging. The role of TREM1, a pro-inflammatory factor, in neurodegenerative diseases is unclear. Here we show that Trem1 deficiency prevents age-dependent changes in myeloid metabolism, inflammation and hippocampal memory function in mice. Trem1 deficiency rescues age-associated...
Edward N Wilson

TP53INP2-dependent activation of muscle autophagy ameliorates sarcopenia and promotes healthy aging

21 hours 33 minutes ago
Sarcopenia is a major contributor to disability in older adults, and thus, it is key to elucidate the mechanisms underlying its development. Increasing evidence suggests that impaired macroautophagy/autophagy contributes to the development of sarcopenia. However, the mechanisms leading to reduced autophagy during aging remain largely unexplored, and whether autophagy activation protects from sarcopenia has not been fully addressed. Here we show that the autophagy regulator TP53INP2/TRP53INP2 is...
David Sebastián

In Science Journals

1 day 1 hour ago
Science, Volume 383, Issue 6690, Page 1428-1429, March 2024.

Michael Funk, and
Ankit Walia,
Marc S. Lavine,
Ian S. Osborne,
H. Jesse Smith,
Yury Suleymanov,
Peter Stern,
Ming Yang,
Courtney Malo,
Gemma Alderton,
Michael A. Funk,
Di Jiang,
Caroline Ash,
Brent Grocholski,
L. Bryan Ray,
Claire Olingy,…

Mandating indoor air quality for public buildings

1 day 1 hour ago
Science, Volume 383, Issue 6690, Page 1418-1420, March 2024.

Lidia Morawska,
Joseph Allen,
William Bahnfleth,
Belinda Bennett,
Philomena M. Bluyssen,
Atze Boerstra,
Giorgio Buonanno,
Junji Cao,
Stephanie J. Dancer,
Andres Floto,
Francesco Franchimon,
Trish Greenhalgh,
Charles Haworth,
Jaap Hogeling, …