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The HEAT repeat protein HPO-27 is a lysosome fission factor
Lysosomes are degradation and signalling centres crucial for homeostasis, development and ageing¹. To meet diverse cellular demands, lysosomes remodel their morphology and function through constant fusion and fission^(2,3). Little is known about the molecular basis of fission. Here we identify HPO-27, a conserved HEAT repeat protein, as a lysosome scission factor in Caenorhabditis elegans. Loss of HPO-27 impairs lysosome fission and leads to an excessive tubular network that ultimately...
RIPK1 and necroptosis role in premature ageing
No abstract
Anti-ageing antibodies revive the immune system
No abstract
How to make an old immune system young again
No abstract
Fructose-1,6-bisphosphatase 1 dephosphorylates and inhibits TERT for tumor suppression
Telomere dysfunction is intricately linked to the aging process and stands out as a prominent cancer hallmark. Here we demonstrate that telomerase activity is differentially regulated in cancer and normal cells depending on the expression status of fructose-1,6-bisphosphatase 1 (FBP1). In FBP1-expressing cells, FBP1 directly interacts with and dephosphorylates telomerase reverse transcriptase (TERT) at Ser227. Dephosphorylated TERT fails to translocate into the nucleus, leading to the inhibition...
TREM1 disrupts myeloid bioenergetics and cognitive function in aging and Alzheimer disease mouse models
Human genetics implicate defective myeloid responses in the development of late-onset Alzheimer disease. A decline in peripheral and brain myeloid metabolism, triggering maladaptive immune responses, is a feature of aging. The role of TREM1, a pro-inflammatory factor, in neurodegenerative diseases is unclear. Here we show that Trem1 deficiency prevents age-dependent changes in myeloid metabolism, inflammation and hippocampal memory function in mice. Trem1 deficiency rescues age-associated...
TP53INP2-dependent activation of muscle autophagy ameliorates sarcopenia and promotes healthy aging
Sarcopenia is a major contributor to disability in older adults, and thus, it is key to elucidate the mechanisms underlying its development. Increasing evidence suggests that impaired macroautophagy/autophagy contributes to the development of sarcopenia. However, the mechanisms leading to reduced autophagy during aging remain largely unexplored, and whether autophagy activation protects from sarcopenia has not been fully addressed. Here we show that the autophagy regulator TP53INP2/TRP53INP2 is...
Overcoming low vision to prove my abilities under pressure
This super-Earth is the first planet confirmed to have a permanent dark side
Sam Bankman-Fried sentencing: crypto-funded researchers grapple with FTX collapse
The corpse of an exploded star and more — March’s best science images
Scientists made a six-legged mouse embryo — here’s why
Copper-catalyzed dehydrogenation or lactonization of C(sp<sup>3</sup>)−H bonds
AI in Africa: Basics Over Buzz
Science, Volume 383, Issue 6690, March 2024.
How a spreadsheet helped me to land my dream job
In Science Journals
Science, Volume 383, Issue 6690, Page 1428-1429, March 2024.
Mandating indoor air quality for public buildings
Science, Volume 383, Issue 6690, Page 1418-1420, March 2024.
Theresa Maldonado is newest AAAS president-elect
Science, Volume 383, Issue 6690, Page 1426-1426, March 2024.
Strengthen the case for DEI
Science, Volume 383, Issue 6690, Page 1395-1395, March 2024.
States in India survey caste membership
Science, Volume 383, Issue 6690, Page 1404-1404, March 2024.