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Alternatives to animal testing are the future — it’s time that journals, funders and scientists embrace them
Are these the happiest PhD students in the world?
AI language models killed the Turing test: do we even need a replacement?
Why we still don’t understand the Universe — even after a century of dispute
Disconnecting part of the brain sends it into a deep sleep
Why simply ending animal testing isn’t the answer in biomedical research
People with blindness can read again after retinal implant
John Gurdon obituary: Biologist who made cloning possible
What’s the cap on human energy expenditure? Elite athletes reveal ‘metabolic ceiling’
Cold plunge: how I gained hands-on experience in marine biology
Neoadjuvant immunotherapy in mismatch-repair-proficient colon cancers
Parity and lactation induce T cell mediated breast cancer protection
Selective Methylene Oxidation in α,β-Unsaturated Carbonyl Natural Products
A surprise bonus from COVID-19 vaccines: bolstering cancer treatment
Patients who got shots of mRNA before starting a type of cancer immunotherapy lived much longer
Stranded coral boulders point to a medieval tsunami in the Caribbean
Study pinpoints likely date for a massive earthquake on the Puerto Rico Trench—and highlights an underappreciated regional hazard
JD Vance officiated the wedding of new head of NIH environmental institute
Unusual hiring process raises fears of political favoritism
Detection and rehabilitation of age-related motor skills impairment: Neurophysiological biomarkers and perspectives
Age-related decline in motor control, manifesting as impaired posture, gait, and slowed movement execution, significantly diminishes the quality of life in older adults. These functional deficits are associated with alterations in neurophysiological data, which are analyzed using advanced techniques including spectral analysis, complexity measures, and functional connectivity network analysis. These methodologies provide valuable insights into the neurobiological mechanisms underpinning...
Compiling Data of Workforce Policies: A Data Compendium About Direct Care Workers Caring for People With Dementia
Direct care workers in long-term care settings are essential to provide care for older adults and people with disabilities who have daily needs. There is an increasing demand for an adequately sized and well-prepared direct care workforce to support people living with dementia due to its rising prevalence. However, a lack of standardized policies and data leaves researchers and policymakers with little evidence to guide the development and refinement of workforce policies. The National Institute...
Brain-derived exosomes from aged mice accelerate cognitive decline in repeated mild traumatic brain injury by activating neuronal Tnfrsf25
Aging increases vulnerability to cognitive decline after repetitive mild traumatic brain injury (rm-TBI), yet mechanisms linking age-related factors to neurodegeneration remain poorly understood. This study investigated how brain-derived exosomes from aged mice (A-Exo) worsen rm-TBI outcomes. In a murine rm-TBI model, intranasal A-Exo administration significantly exacerbated spatial memory deficits and hippocampal neuronal apoptosis compared to brain-derived exosomes from young mice (Y-Exo) or...
Empagliflozin slows down natural kidney senescence via Six1/Wnt4/NF-kappaB pathway
Age-related renal impairment often occurs insidiously and has become an important cause of chronic renal failure, especially when individuals with other chronic diseases. However, there is lack of effective treatments. Research on diabetic patients has revealed that empagliflozin (EMPA), one of sodium-glucose cotransporter 2 (SGLT-2) inhibitors, exhibits a distinct protective effect on aging kidneys. EMPA has been shown to improve renal fibrosis and ameliorate inflammatory cytokines, including...