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Association between visual impairment and recurrent hospitalizations in older US adults
CONCLUSION: Near VI is significantly associated with recurrent hospitalization in older US adults. Future studies should determine whether improving near vision affects the likelihood of recurrent hospitalization.
How fast is your brain ageing? Proteins in blood offer clues
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Human body's ageing 'clock' ticks faster after heat stress
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Plasma proteomics identify biomarkers and undulating changes of brain aging
Proteomics enables the characterization of brain aging biomarkers and discernment of changes during brain aging. We leveraged multimodal brain imaging data from 10,949 healthy adults to estimate brain age gap (BAG), an indicator of brain aging. Proteome-wide association analysis across 4,696 participants of 2,922 proteins identified 13 significantly associated with BAG, implicating stress, regeneration and inflammation. Brevican (BCAN) (β = -0.838, P = 2.63 × 10^(-)^(10)) and growth...
ADAM10-mediated beta-klotho degradation: a key to FGF21 resistance in senescent vascular endothelial cells
Fibroblast growth factor 21 (FGF21) is a key regulator of metabolism and cardiovascular health. However, its upregulation in aging and age-related disorders suggests the presence of FGF21 resistance. This study aimed to elucidate the mechanisms underlying senescence-associated FGF21 resistance in human umbilical vein endothelial cells (HUVECs) and to explore potential therapeutic interventions. Transcriptomic analysis revealed a significant reduction in the number of FGF21-regulated genes in...
Google passes milestone on road to an error-free quantum computer
Quantum bits’ delicate states preserved by spreading them out