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Mitochondrial quality control in cardiomyocytes: safeguarding the heart against disease and ageing
Mitochondria are multifunctional organelles that are important for many different cellular processes, including energy production and biosynthesis of fatty acids, haem and iron-sulfur clusters. Mitochondrial dysfunction leads to a disruption in these processes, the generation of excessive reactive oxygen species, and the activation of inflammatory and cell death pathways. The consequences of mitochondrial dysfunction are particularly harmful in energy-demanding organs such as the heart. Loss of...
Texasin, A main product from Caragana Jubata (Pall.) Poir, induces proliferation arrest and protective autophagy in lung adenocarcinoma
CONCLUSIONS: Texasin emerges as a promising non-cytotoxic anti-lung adenocarcinoma cancer compound, significantly inhibiting malignant phenotypes, highlighting its potential for lung adenocarcinoma cancer therapy.
Sociodemographic Factors in Older Adults' Gait Speed Decline: A Gender Disaggregate Growth Curve Analysis of the Ibadan Longitudinal Study of Ageing
BackgroundGait speed is an important predictor of older adults' well-being. We estimated the influence of sociodemographic factors on the gait speed decline of community-dwelling older Nigerians.MethodsUsing the Ibadan Study of Ageing (2007, 2008, and 2009 cycles), we completed a gender disaggregate analysis of sociodemographic influences on participants' gait speed trajectory using mixed-design ANOVA and growth curve analysis.ResultsAt baseline, 53.2% of participants were female, 61.9% were...
‘Orchestrated assault’: New tsunami of NIH grant cuts hits South Africa hard
Agency moves to terminate nearly 1000 awards, including programs involving “DEI”
Daily briefing: Babies make memories — so why don’t we recall them?
Publisher Correction: A metagenomic ‘dark matter’ enzyme catalyses oxidative cellulose conversion
NIH has cut one mRNA-vaccine grant. Will more follow?
‘Boggles the mind’: US defence department slashes research on emerging threats
Author Correction: AI models collapse when trained on recursively generated data
Author Correction: Heritable polygenic editing: the next frontier in genomic medicine?
A systematic review with a Burden of Proof meta-analysis of health effects of long-term ambient fine particulate matter (PM<sub>2.5</sub>) exposure on dementia
Alarmingly large care deficits globally for people living with dementia and disability
‘All this is in crisis’: US universities curtail staff and spending as Trump cuts take hold
Ship-pollution cuts have an electrifying effect: less lightning at sea
The Sikkim flood of October 2023: Drivers, causes, and impacts of a multihazard cascade
Science, Volume 387, Issue 6740, March 2025.
Unifying spatial scaling laws of biodiversity and ecosystem stability
Science, Volume 387, Issue 6740, March 2025.
Epithelial polarization by the planar cell polarity complex is exclusively non–cell autonomous
Science, Volume 387, Issue 6740, March 2025.
Synaptic architecture of a memory engram in the mouse hippocampus
Science, Volume 387, Issue 6740, March 2025.
Regulatory T cells constrain T cells of shared specificity to enforce tolerance during infection
Science, Volume 387, Issue 6740, March 2025.
One red square can change your entire perception of the world
New film explores how scientists see nature differently from each other—and from everyone else