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Extreme warming of Amazon waters in a changing climate

1 week 5 days ago
Science, Volume 390, Issue 6773, Page 606-611, November 2025.
Ayan Santos Fleischmann, Fabrice Papa, Stephen K. Hamilton, John Melack, Bruce Forsberg, Adalberto Val, Walter Collischonn, Leonardo Laipelt, Júlia Brusso Rossi, Bruno Comini de Andrade, Bruna Mendel, Priscila Alves, Maiby Bandeira, Lady Custódio, Maria…

Platforms of power

1 week 5 days ago
Science, Volume 390, Issue 6773, Page 580-580, November 2025.
Simson L. Garfinkel

A probabilistic histological atlas of the human brain for MRI segmentation

1 week 6 days ago
In human neuroimaging, brain atlases are essential for segmenting regions of interest (ROIs) and comparing subjects in a common coordinate frame. State-of-the-art atlases derived from histology^(1-3) provide exquisite three-dimensional cytoarchitectural maps but lack probabilistic labels throughout the whole brain: that is, the likelihood of each location belonging to a given ROI. Here we present NextBrain, a probabilistic histological atlas of the whole human brain. We developed artificial...
Adrià Casamitjana

Lymphoid gene expression supports neuroprotective microglia function

1 week 6 days ago
Microglia, the innate immune cells of the brain, play a defining role in the progression of Alzheimer's disease (AD)¹. The microglial response to amyloid plaques in AD can range from neuroprotective to neurotoxic². Here we show that the protective function of microglia is governed by the transcription factor PU.1, which becomes downregulated following microglial contact with plaques. Lowering PU.1 expression in microglia reduces the severity of amyloid disease pathology in mice and is linked to...
Pinar Ayata

Hippocampal 1H-MR spectroscopy metabolites are linked to CSF tau pathology in cognitively unimpaired older adults along the Alzheimer's continuum

1 week 6 days ago
Relationships between Alzheimer's disease (AD) pathologies in cognitively unimpaired adults and in vivo neurometabolic properties measured directly from the hippocampus, a vulnerable region early along the AD continuum, are not well-understood in the earliest stages of AD. In a 3T ¹H-MRS study, we assessed age and AD-related changes in estimates of absolute concentrations of neurometabolites in the right hippocampus. Participants included older adults (age range: 60-85, n = 19) primarily...
Jessica N Lingad

Long-lived IgE plasma cells persist in secondary lymphoid tissues using a navitoclax-sensitive survival program

1 week 6 days ago
Long-term allergies can exhibit persistent concentrations of circulating immunoglobulin E (IgE). Here, we examined the lifespan of IgE antibody-secreting cells (ASCs) to determine whether the IgE that sustains allergies receives contributions from long-lived cells or relies more heavily on constant ASC production. In mouse aeroallergy, IgE ASCs localized to the lungs, mediastinal lymph nodes, spleen, and bone marrow (BM). IgE ASC production continued for months after allergen exposure ceased. We...
Zhoujie Ding

AI-driven aging digital twins: A roadmap for clinical translation in precision geriatrics

1 week 6 days ago
Aging and related diseases account for ⁓70 % of global mortality with declining physiological homeostasis and cognitive function increasing susceptibility to neurodegenerative disorders, cardiovascular diseases and cancer. Treatment is hampered by imprecise diagnostics and limited therapeutic options. Precision medicine involving artificial intelligence (AI)-powered Aging Digital Twin (ADT) technology which integrates multi-source heterogeneous data via advanced AI and deep learning has great...
Chenchen Li

Lipoprotein metabolism and its impact on life expectancy

1 week 6 days ago
CONCLUSION: Lipoprotein metabolism plays a central role in determining healthspan and longevity. Understanding the cross-species diversity and regulatory mechanisms of lipid transport provides critical insights into aging biology. Advances in pharmacology, nutrition, and genetic technology offer promising tools to modulate lipoprotein profiles and promote healthy aging in humans.
Michał Skrzycki

The importance of past rifting in large igneous province development

1 week 6 days ago
Lithospheric thin zones, such as recently failed rifts, are generally assumed to be weak spots where magmatism and deformation can concentrate during rifting and large igneous province development^(1-3). Yet, the Turkana Depression in East Africa, the site of the failed 66-million-year-old Anza Rift, did not experience the widespread flood magmatism seen on the adjacent Ethiopian Plateau, despite being a lithospheric thin spot when the region encountered hot plume material around 45 million...
R Kounoudis