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Cisformer: a scalable cross-modality generation framework for decoding transcriptional regulation at single-cell resolution
Single-cell multiomic technologies enable the joint analysis of different modalities, but face challenges due to experimental complexity. Current computational methods for single-cell cross-modality translation lack biological interpretability. Here, we present Cisformer, a cross-attention-based generative model tailored for cross-modality generation between gene expression and chromatin accessibility at single-cell resolution. Systematic benchmarking demonstrates the superior accuracy and...
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Stop treating code like an afterthought: record, share and value it
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The 1975 discovery of long-lost letters between Albert Einstein and the astronomer Willem de Sitter
Stop destructive fishing in marine protected areas
Insect biodiversity monitoring must be expanded
Prizes must recognize machine contributions to discovery
Quantum effects in electrical circuits honored with Physics Nobel
Breakthrough paved the way to many of today’s budding quantum computers
Missing wind from Milky Way’s giant black hole finally found
Astronomers may have glimpsed a long-predicted wind of gas blowing out from Sagittarius A*
Well-exercised male mice appear to pass fitness to their male offspring
Surprising epigenetic effect relies on snippets of RNA packaged within sperm
Effect of Origanum majorana tea on oxidative stress biomarkers in Parkinson's disease: a randomized placebo-controlled pilot study
CONCLUSION: Origanum majorana infusion may enhance or regulate antioxidant status and reduce oxidative damage in patients with PD. Further studies are warranted to explore its potential therapeutic benefits.
PARL stabilizes mitochondrial BCL-2 via Nur77-mediated scaffolding as a therapeutic strategy for Parkinson's disease
Parkinson's disease (PD) involves both mitochondrial dysfunction and Lewy body pathology. However molecular links between these features remain unclear. Here, we identify Presenilin-associated rhomboid-like protein (PARL) as a Lewy body component, RARL regulates mitochondrial apoptosis via interacting with orphan nuclear receptor Nur77. Clinical profiling revealed reduced plasma PARL levels in 71 PD patients versus controls (p < 0.001), which correlated with disease severity. In MPP^(+)/MPTP...