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Monolithic 3D integration of tantalum pentoxide nonlinear photonics
Giant cancer study reveals effectiveness of ‘off label’ treatments
Carbonyl swapping converts cyclic ketones to saturated heterocycles
Author Correction: HER2 expression identifies dynamic functional states within circulating breast cancer cells
Editorial Expression of Concern: Creation of human tumour cells with defined genetic elements
Retraction Note: The hidden fitness of the male zebra finch courtship song
Cytoplasmic lattices are megadalton storage complexes in mammalian oocytes
Ozymandias undead
Why more fossil fuels won’t fix the Iran energy crisis
Can China’s Great Green Wall shape efforts to keep the world’s deserts at bay?
I was set to lead an undergraduate research trip abroad. Then my visa was denied
What China’s Great Green Wall can teach the world
Dozens of AI disease-prediction models were trained on dubious data
Imaging interface-controlled bulk oxygen spillover
Plasma phosphorylated tau 217 and longitudinal trajectories of Aβ, tau, and cognition in cognitively unimpaired older adults
Plasma phosphorylated tau 217 (pTau217) is an excellent biomarker of Alzheimer's disease (AD) pathology, but it remains uncertain whether pTau217 can predict amyloid-β (Aβ) and tau accumulation prior to Aβ positron emission tomography (PET) positivity. Here, we leverage data from a well-characterized prospective cohort of cognitively unimpaired older adults to examine mass spectrometry-based plasma %pTau217 (pTau217/non-phosphorylated-Tau217×100) relative to changes in Aβ/tau PET and cognition....
Signaling cascades shape functional subpopulations of cortical astrocytes in male wild-type mice and APP/PS1dE9 Alzheimer's disease model
Astrocytes are key partners for neurons and can impact diseases such as Alzheimer's disease (AD), as they exhibit multiple reactive changes. Recent single cell/nucleus genomics analyses evidence astrocyte subpopulations coexisting in normal and AD brains. However, the signaling cascades controlling them, their functional characteristics and roles in AD are still unknown. Here, thanks to astrocyte-specific reporters for STAT3 and NF-kB signaling pathways, two regulators of astrocyte reactivity,...
Alzheimer disease protection from the periphery
No abstract
Astrocyte-based CAR immunotherapy against Alzheimer's disease
No abstract
Altered theta distribution and coherence during set-shifting in older age
Cognitive flexibility is an executive function that enables adapting behaviour to a changing environment and is thus critical for daily life. The degree of its preservation upon healthy aging and the neural mechanisms underlying it are still a matter of debate. To investigate the electrophysiological correlates of cognitive flexibility in older age, we measured cognitive flexibility in 99 young (24.75 ± 4.45 years) and 83 older adults (69.19 ± 6.25) using electroencephalography (EEG). Compared...
A dual role for cGAS in shaping cellular and organismal responses to genomic instability
Mutations in DNA damage repair (DDR) genes lead to genomic instability, driving a range of degenerative syndromes. In addition to promoting mutation accumulation, unrepaired DNA damage can leak into the cytosol and activate innate immune-sensing pathways, particularly the cGAS-STING axis. However, the extent to which cGAS causally contributes to organismal pathology in DDR syndromes in vivo remains unresolved. Here, we genetically model ataxia telangiectasia (A-T) and Bloom syndrome in the...