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Disinformation campaign may have triggered “brutal” shutdown of mosquito lab

Two analyses of microbial DNA in tumor samples aim to put controversy-riddled field back on track

Chikungunya cases break records in France; West Nile virus appears near Rome

Government sets requirements for new space that sound like nearby patent office campus

Dynamic changes in dopamine, noradrenaline, and serotonin release are believed to causally contribute to the neural computations that support reward-based decision making. Accordingly, changes in signaling by these systems are hypothesized to underwrite multiple cognitive and behavioral symptoms observed in many neurological disorders. Here, we characterize the release of these neurotransmitters measured concurrently in the caudate of patients with Parkinson's disease or essential tremor...

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CONCLUSION: This study reveals that social networks and depressive symptoms jointly mediate the relationship between volunteer participation and life satisfaction among older adults in China. These findings provide empirical support for integrating social and psychological mechanisms into models of active ageing. Promoting volunteer engagement may enhance both social connectedness and mental health, ultimately improving quality of life in later life.

Cellular senescence is accompanied by extensive genomic reorganization, such as senescence-associated heterochromatin foci and expanded interchromatin compartments, to ultimately affect gene expression. Here, we demonstrate that chromatin structural changes in senescent cells drive significant alterations in the phase behavior and motility of paraspeckles, a type of interchromatin compartment condensate. We observe increased numbers, size, and elongation of paraspeckles harboring NONO and...

Age-related inflammation or 'inflammaging' increases disease burden and controls lifespan. Adipose tissue macrophages (ATMs) are critical regulators of inflammaging; however, the mechanisms involved are not well understood in part because the molecular identities of niche-specific ATMs are unknown. Using intravascular labeling to exclude circulating myeloid cells followed by single-cell sequencing with orthogonal validation via multiparametric flow cytometry, we define sex-specific changes and...

CONCLUSIONS: Sarcopenia and short sleep duration independently and jointly hinder successful aging. Community sarcopenia screening integrated into primary care and advocating adequate sleep duration may served as a cost-effective successful aging strategy.