Aggregator
Ancient shackles testify to brutality of Egypt’s gold mines
Fasting for weight loss is all the rage: what are the health benefits?
Climate change will send home insurance spiralling. Here’s how to control costs
How the Atlantic jet stream has changed in 600 years — and what it means for weather
Why is my cello howling?
MFSD6 is an entry receptor for enterovirus D68
Microbes can capture carbon and degrade plastic — why aren’t we using them more?
How to get more women into mining
Lesotho matters
Give grants to female scientists in war zones
Lessons from Portugal on effects of cutting research funding
A year later, cow flu origins are an unsettling puzzle
It's still unclear how H5N1 virus jumped into U.S. cattle—and why it keeps doing so
Saying ‘pandemic is over,’ NIH starts cutting COVID-19 research
Grant terminations halt research on improving vaccinations and preventing future pandemics
Trump cuts damage global efforts to track diseases, prevent outbreaks
Disease surveillance programs worldwide are suddenly in limbo
Mexican whale researchers sound the alarm on an energy megaproject
A planned gas terminal would routinely send huge tankers through a marine mammal oasis, scientists fear
Ca<sub>V</sub>2.1 mediates presynaptic dysfunction induced by amyloid β oligomers
Synaptic dysfunction is an early pathological phenotype of Alzheimer's disease (AD) that is initiated by oligomers of amyloid β peptide (Aβ(o)s). Treatments aimed at correcting synaptic dysfunction could be beneficial in preventing disease progression, but mechanisms underlying Aβ(o)-induced synaptic defects remain incompletely understood. Here, we uncover an epithelial sodium channel (ENaC) - Ca(V)2.3 - protein kinase C (PKC) - glycogen synthase kinase-3β (GSK-3β) signal transduction pathway...
Targeted degradation of α-Synuclein using an evolved botulinum toxin protease
There is considerable interest in the targeted degradation of proteins implicated in human disease. The use of sequence-specific proteases for this purpose is severely limited by the difficulty in engineering the numerous enzyme-substrate interactions required to yield highly selective proteases while maintaining catalytic activity. Herein, we report a strategy to evolve a protease for the programmed degradation of α-Synuclein, a presynaptic protein closely linked to Parkinson's disease. Our...
Correction to: White matter lipid alterations during aging in the rhesus monkey brain
No abstract
Ordered zinc electrodeposition from single-crystal units to polycrystalline stacking within solid-electrolyte interphase in battery anodes
Controlling Zinc (Zn) nucleation and subsequent crystal growth are critical for long lifespan aqueous zinc metal batteries. However, the concurrent side reactions and unstable solid-electrolyte interphase (SEI) formations impedes the continuous Zn metal electrodeposition. Herein, induced by a well-designed organic/inorganic dual-phase SEI, we realize ordered zinc electrodeposition of polycrystalline stackings from single-crystal building blocks. The uncommon SEI with appropriate ion transport...
Religiosity, Religious Beliefs, and Cognitive Impairment Among Black and White Men With Modest Incomes
ObjectiveThe objective of this study was to examine the association between religious practices, beliefs, and cognitive impairment among Black and White men with modest incomes in the 2016 Health and Retirement Study.MethodsData were drawn from Black and White men who reported annual incomes at or below $50,000 (n = 926). The primary outcome was any cognitive impairment, a dichotomous variable derived from a modified version of the Telephone Interview for Cognitive Status. The religious...