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Extracellular Vesicles Favor Early Peripheral Immunosenescence Through Modulation of the Senescence-Associated Secretory Phenotype in HIV Infection
HIV infection induces chronic immune activation, predisposing people living with HIV (PLWH) to early immunosenescence. It is essential to understand the mechanisms behind the senescence-associated secretory phenotype (SASP). This study investigates the role of extracellular vesicles (EVs) in peripheral immunosenescence in HIV infection associated with SASP modulation. Biological and in silico analyses were performed to explore the crosstalk between EVs, miR-21-5p, and SASP. Plasma EVs from PLWH...
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