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GLP-1 receptor agonists, epigenetic aging, and the prospect of pharmacological healthspan extension
Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) reduce major adverse cardiovascular events, all-cause mortality, and systemic inflammation in randomized controlled trials, with effect sizes exceeding those predicted from glycemic and weight-related improvements alone. The convergence of these findings with a maturing body of evidence linking metabolic dysfunction to accelerated epigenetic aging has prompted renewed interest in GLP-1 RAs as candidate gerotherapeutic agents. The present...
Bidirectional associations between loneliness and physical multimorbidity and the mediating role of social inactivity
Physical multimorbidity and loneliness are increasingly recognised as public health concerns, but the nature of their potential relationships remains unclear. Here we report bidirectional associations between physical multimorbidity and loneliness in middle-aged and older adults and the mediating role of social inactivity. Longitudinal data from adults aged ≥45 years are analysed across 19 countries from five prospective cohorts: US Health and Retirement Study; English Longitudinal Study on...
Beyond redlining: Gentrification, displacement, disadvantages, and exclusivity predict urban environmental and health inequities
This study investigated environmental justice by developing and comparing four contemporary urban segregation typologies (persistent exclusivity, persistent disadvantage, recent gentrification, and recent displacement-hosting) with historical Homeowners' Loan Corporation (HOLC) zones and 104 variables spanning the natural and built environments, pollution, environmental hazards, health, and disability. We applied principal component analysis to the 2010 and 2020 American Community Survey and the...
Synaptic Mitochondrial Oxidative Stress Contributes to Individual Variability in Age-Related Cognitive Inflexibility in Mice
Aging is associated with impairments in cognitive flexibility, a key executive function supported by the medial prefrontal cortex (mPFC), yet the biological mechanisms underlying individual variability in age-related decline remain poorly understood. Here we investigated behavioral, ultrastructural, and proteomic correlates of cognitive inflexibility in mice across aging. Using a touchscreen-based attentional set-shifting task, we observed substantial individual variability in cognitive...
Daily briefing: How this year’s super El Niño is different
A microprotein atlas of the human frontal cortex in Alzheimer’s disease
Large-scale mapping of microproteins in the aged human brain
‘Multifunctional’ brain implant translates speech and gestures in real time
Science philanthropy is rising in Brazil ― upending a long tradition
Encoded and non-genetic protein variants expand human functional proteome
Drug firms’ secret data supercharge AI protein models
Fraud sealed the fate of controversial zoologist Paul Kammerer — 100 years on, his ideas deserve revisiting
UK universities are on the brink — what is their greatest source of stress?
The pet trade puts reptiles and amphibians at risk: close legal gaps now
How is climate change affecting conifers and their ability to sequester carbon?
The roots of astrology, the mysterious nature of time and more: Books in brief
Three wild dogs have traveled farther than any African mammal
Record-breaking “odyssey” suggests populations of these highly endangered carnivores are more connected than thought
Scientists find how “zombie” cells fuel inflammation as we age
Scientists discovered that aging cells can use malfunctioning mitochondria to unlock inflammatory genes and keep the immune system stuck in a prolonged state of alert. Blocking one part of this process reduced inflammation and improved healthy aging in mice, suggesting a promising new strategy for fighting age-related decline.
NSF memo implementing Trump’s ‘golden age’ of science unsettles researchers
New document emphasizes support for White House priorities over curiosity-driven ideas
Popular sweetener byproduct damages DNA in human cells
Sucralose, the artificial sweetener used in Splenda, came under scrutiny after a study found that a related chemical damaged DNA and weakened the gut barrier in laboratory experiments. But later findings have complicated that alarming picture.