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Advances in the multifunctional roles of CX3CL1 in the central nervous system
C-X3-C motif chemokine ligand 1 (CX3CL1), a structurally unique chemokine in the central nervous system (CNS), shapes physiological and pathological processes via specific binding to its receptor, C-X3-C motif chemokine receptor 1 (CX3CR1). Empirical evidence indicates that this signaling axis exerts dual neuroinflammatory effects: It restrains microglial hyperactivation, yet can promote inflammation under conditions such as chronic stress. Notably, it preserves synaptic plasticity and...
Longitudinal Associations Between Neurodegenerative Biomarkers and Cognitive Decline in Older Adults: Insights From the LASI-DAD Study
CONCLUSIONS: Our findings suggest that biomarkers, including GFAP and NfL, are associated with cognitive decline over time in older adults in India. These biomarkers may serve as important indicators for monitoring cognitive aging and dementia risk in this population.
Negotiating Care and Risk in Thelma (2024)
In Thelma (2024), June Squibb sidesteps those who try to impose limitations on her and deftly commandeers available resources to exact revenge on a set of scammers.