Aggregator

We aimed to examine the mediating role of accelerated aging in the association between diet quality and CVD incidence and mortality. Data were obtained from the UK Biobank cohort. Diet quality was evaluated using four established indices: the Healthy Eating Index-2020, the Alternative Healthy Eating Index, the Dietary Approaches to Stop Hypertension index, and the Mediterranean Diet Score. Accelerated aging was assessed by the Phenotypic Age Acceleration and Biological Age Acceleration. Outcomes...

Executive and motor function are bidirectionally linked and decline as we age, yet motor-cognitive links are predominantly studied in older adults, while studies focused on midlife report mixed results. We aimed to evaluate whether motor tasks of varying complexity reflect executive function in midlife, a sensitive window for identifying early cognitive-functional risks that are otherwise undetected, thus informing timely intervention strategies. Using a cross-sectional study design, we assessed...

Despite the female predominance in age- and immune-associated diseases, the pathways underlying sex differences in healthy immune aging remain incompletely understood. Here, we analyze a multi-ethnic single-cell transcriptome of healthy human immune aging (35% Asian), comprising 3.8 million peripheral blood mononuclear cells (PBMCs) from 1,828 individuals aged 19-97 years. Prominent peaks of differential gene expression around 40 (mainly CD4 T cells) and after 60 (mainly CD8 T cells) years of...

Alzheimer's disease (AD) remains a major unmet medical challenge despite decades of progress in medicines that target tau and amyloid-β (Aβ) pathology. The clinical benefit of monoclonal antibodies (mAbs) against Aβ is limited, with current data showing only slight slowing of cognitive decline despite encouraging biomarker responses and recent regulatory approval of these drugs. Moreover, their wider clinical use is restricted by dose-dependent toxicities such as amyloid-related imaging...

CONCLUSIONS: Multimorbidity and greater cumulative LTC burden were prospectively associated with incident sarcopenia in both females and males. The graded association across LTC burden and the estimated population-level burden suggest that multimorbidity is an important marker of subsequent sarcopenia risk. Further research should determine whether incorporating muscle health assessment into the care of people with multimorbidity improves prediction or clinical outcomes.

CONCLUSION: Overall, the present study demonstrates for the first time that Nampt activation via P7C3 injections allows for improved fast and slow skeletal muscle function in aged mice with increased muscle quality, myofiber CSA and preserved grip strength.

Traditional vascular aging research has predominantly focused on isolated pathologies in single vascular beds, which fails to explain the synchronized functional decline of multiple organ systems that defines organismal aging. While the panvascular aging paradigm has emerged as a transformative framework for understanding systemic aging, the field remains fragmented by inconsistent phenotypic definitions, arbitrary model selection, and a critical disconnect between basic mechanistic insights and...

Ancient DNA reveals that plague repeatedly returned to Europe for more than 400 years after the Black Death, evolving into new lineages and spreading through trade, migration, and war. Researchers also developed a method to date ancient plague genomes more precisely, linking many of them to specific outbreaks recorded in historical sources.

Researchers have uncovered a hidden molecular warning sign of inflammatory bowel disease (IBD) that can linger even when patients feel well and appear to be in remission. By studying around 900 human gut biopsies and patient-derived mini-intestines, the team found that intestinal cells can remain unusually primed to die, creating a “smoldering” defect that may help drive future flare-ups.

A growing Bundibugyo virus outbreak is showing how a little-known relative of Ebola can become a major threat when diagnosis and treatment options are limited. Experts warn that preparing only for familiar pathogens could leave the world vulnerable when rare but deadly viruses suddenly reemerge.

Complex systems may work better when their parts are not perfectly alike. Northwestern physicists found that carefully balanced variation, or “disorder,” can make networks such as power grids, ecosystems, neurons, and materials more stable. Even random differences sometimes improved stability compared with completely uniform systems. The discovery could help researchers design more resilient technologies and explain why natural systems are so rarely perfectly uniform.

Scientists have identified the genetic cause behind the mysterious AnWj blood group antigen, solving a puzzle that began in 1972 and establishing a new blood group system called MAL. The discovery could make it much easier to find extremely rare AnWj-negative patients and donors and protect them from potentially dangerous transfusion reactions.

BackgroundSubjective cognitive impairment (SCI) predicts Alzheimer's disease and related dementias (ADRD). Identifying SCI correlates may identify cognitive risk earlier in the ADRD continuum. We examined SCI correlates among older non-Hispanic Black (NHB) and non-Hispanic White (NHW) men.MethodCross-sectional data were from 669 men in the 2012 National Health and Aging Trends Study. Logistic regression was used to identify SCI correlates, accounting for complex sampling and...

With the global aging population and increasing burden of age-related diseases, delaying aging and maintaining healthspan have become important research priorities. Aging is a complex biological process involving progressive declines in physiological function, stress resistance, proteostasis, and metabolic homeostasis, driving the development of aging modulators that target conserved longevity-associated pathways. Although pharmacological and natural aging modulators have attracted growing...

CONCLUSION: High BMI-attributable stage 2-4 CKM burden has risen sharply in China and will continue to increase, driven mainly by worsening epidemiological risks. AFF, IHD, and LEPAD show the fastest growth. Men had higher age-standardized mortality and DALY rates for several selected diseases. Early-life obesity prevention and sex-tailored interventions are urgently needed.

CONCLUSION: LLM-derived mobility functional status assessment was associated with ED visits and hospitalization, but not with all-cause mortality after adjustment. Prospective validation and evaluation of incremental discrimination, calibration, and clinical utility are needed before clinical implementation.

Scientists discovered a population of cells that can start the process of programmed cell death, survive it, and then help rapidly rebuild damaged tissue. Their descendants become far more resistant to future damage, revealing a mechanism that could improve healing but may also help cancers return after treatment.

No abstract

Alzheimer disease (AD) is defined biologically by the presence of amyloid-β (Aβ) plaques and tau neurofibrillary tangles in the brain; however, these pathologies do not affect all brain regions equally. Typical AD usually presents with memory impairment, whereas atypical forms of AD, including posterior cortical atrophy, logopenic variant primary progressive aphasia, behavioural and dysexecutive AD, and corticobasal syndrome, manifest with prominent non-memory symptoms. Aβ biomarkers usually...

The ability to initiate stepping promptly and accurately is critical for safe mobility in later life. Choice stepping reaction time (CSRT) is an independent predictor of recurrent falls in older adults and is often prolonged in dementia. Although the prefrontal cortex (PFC) is crucial for rapid response execution, existing studies primarily focus on regional activation, leaving the topological reorganization of prefrontal functional networks poorly understood. In this study, twenty-six healthy...