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Cell-free chromatin state tracing reveals disease origin and therapy responses
Mechanism of co-transcriptional cap snatching by influenza polymerase
Microbiota-mediated induction of beige adipocytes in response to dietary cues
Merlin: a computed tomography vision–language foundation model and dataset
Lipid metabolism drives dietary effects on T cell ferroptosis and immunity
Long-term thrombus-free left atrial appendage occlusion via magnetofluids
A metabolic alarmin from keratinocytes potentiates systemic humoral immunity
Limited thermal tolerance in tropical insects and its genomic signature
DICER cleavage fidelity is governed by 5′-end binding pockets
Genome modelling and design across all domains of life with Evo 2
Magnetic gel injected into the heart could stop strokes
Heart surgery with quick-setting magnetic fluid could prevent strokes
Shared neural substrates of prosocial and parenting behaviours
ACSS2 maintains oligodendrocyte progenitor cell pool and is required for myelination during development and aging
Cancer blood tests are everywhere. Do they really work?
Climate change and geopolitics threaten water supplies — but disaster is not inevitable
GLP-1 drugs linked to lower addiction rates in large study of veterans
The treatments appeared to help prevent a wide range of substance use disorders and reduce serious harms from existing ones
Delays in awards and funding calls worry NIH-funded researchers
Many programs may be pushed into the next fiscal year, and some could face funding gaps
Virus-mediated gene transfer of soluble amyloid precursor protein-alpha via systemic injection in a mouse model of Alzheimer's disease
Alzheimer's disease (AD) is the most common neurodegenerative disorder, yet effective preventive or therapeutic strategies remain limited. A hallmark of AD pathology is the accumulation of insoluble amyloid-β (Aβ) aggregates, which are targeted by recent antibody-based therapies. Conversely, soluble amyloid precursor protein-alpha (sAPPα), a non-amyloidogenic cleavage product of APP, possesses neuroprotective, neurotrophic, and synaptogenic properties, and the ability to enhance memory. This...
Integrative epigenomic landscape of Alzheimer's Disease brains reveals oligodendrocyte molecular perturbations associated with tau
Alzheimer's disease (AD) brains have variable neuropathologic and biochemical changes. Capturing epigenetic factors associated with this variability can reveal novel biological insights into AD pathophysiology. Here, we conduct an epigenome-wide association study of DNA methylation in 472 AD brains with neuropathologic and biochemical brain protein levels core to AD pathogenesis. Using a novel regional methylation (rCpGm) approach, we identify 5478 significant associations, 99.7% of which...