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Substantial water retained early in Earth’s deep mantle
Science, Volume 390, Issue 6778, Page 1177-1180, December 2025.
Mesoporous optically clear heat insulators for sustainable building envelopes
Science, Volume 390, Issue 6778, Page 1171-1176, December 2025.
Global energy sector methane emissions estimated by using facility-level satellite observations
Science, Volume 390, Issue 6778, Page 1151-1155, December 2025.
Observation of Shapiro steps in an ultracold atomic Josephson junction
Science, Volume 390, Issue 6778, Page 1130-1133, December 2025.
Chromothripsis and ecDNA initiated by N4BP2 nuclease fragmentation of cytoplasm-exposed chromosomes
Science, Volume 390, Issue 6778, Page 1156-1163, December 2025.
The statusocratic dilemma
Science, Volume 390, Issue 6778, Page 1108-1108, December 2025.
Dealing with distressing dreams
Science, Volume 390, Issue 6778, Page 1107-1107, December 2025.
New antibiotics for gonorrhea could help beat back drug-resistant infections
Two treatments for the sexually transmitted disease are expected to become available soon
Congress imposes new security restrictions on U.S. researchers
But new defense bill drops or weakens some controversial proposals
Heat-seeking beetles drawn to plants that glow in infrared
Pollinators’ antennae act like thermal cameras to spot self-heating plants
NASA telescope will hunt down ‘city killer’ asteroids
With an infrared eye, NEO Surveyor will target dangerous space rocks glowing in the dark
Want to sway an election? Here’s how much fake online accounts cost
Systematic price monitoring sheds light on economics of online manipulation
Predictive modeling approaches for Alzheimer's disease diagnosis through neuroimaging techniques
Alzheimer's disease (AD) is one of the brain's neurodegenerative diseases. It is distinguished by a progressive mental, social, and behavioral deterioration. It affects the person's capacity, thinking, attention, reasoning, social behavior and functionality to achieve independence. The classical diagnosis process of AD consists of variety of neuroimaging scan approaches such as computerized tomography, magnetic resonance imaging and positron emission tomography. Classical cerebrospinal fluid...
Seed amplification of MSA alpha-synuclein aggregates preserves the biological and structural properties of brain-derived aggregates
Parkinson's disease (PD), Dementia with Lewy bodies (DLB), and multiple system atrophy (MSA), are characterized by the misfolding and aggregation of alpha-synuclein (αSyn). Compelling evidence showed that αSyn aggregates exist as distinct conformational strains in different synucleinopathies. Recently, we reported that the αSyn Seed Amplification Assay (αSyn-SAA) can amplify and distinguish αSyn strains from PD and MSA. In this study, we investigate whether MSA-seeded, SAA-amplified αSyn fibrils...
Chimeras co-targeting antigens and FcγRIIb trigger degradation of extracellular soluble proteins and pathological aggregates
While the clinical utility of conventional antibody therapies is undeniable, their therapeutic potential is often constrained high antigen loads and the recycling of antibody-antigen complexes via neonatal Fc receptor (FcRn). Here, we present a platform, based on a design similar to bispecific antibodies, FcγRIIb-Targeting Chimeras (FcRTAC). These constructs recognise antigens with one arm and bind FcγRIIb with the other arm to harness the unique endocytic properties of FcγRIIb to direct the...
Measuring biological age: Insights from omics studies
Biological ageing is a systemic, multifactorial process driven by progressive molecular and cellular alterations whose complexity necessitates systems-level approaches. Advances in high-throughput omics technologies now allow simultaneous quantification of millions of biomolecules from a single specimen, enabling longitudinal, integrative profiling across multiple molecular layers. This review synthesizes recent progress in applying genomics, epigenomics, metabolomics and microbiomics to ageing...
The promise of organ rejuvenation to overcome the shortage in organ transplantation
Organ shortage remains a major barrier in treating end-stage organ failure, with many patients dying while waiting or becoming medically unfit by the time an organ is offered. A substantial number of organs, particularly from older donors, remain unused due to concerns over age-related decline in quality. This review highlights emerging strategies to rejuvenate and optimize such organs by mitigating ischemia-reperfusion injury and reducing age-related immunogenicity. Advances in organ...
Revealing heterogeneity and damage response in the adult human utricle
The human utricle is a vestibular organ essential for balance, a function that declines with age. With the aging population projected to double to 2 billion by 2050 and no pharmaceutical or biological treatments available, balance disorders represent a significant unmet medical need. The utricle is composed of sensory and non-sensory cells, which are closely related. Non-sensory cells have limited capacity to regenerate sensory cells and, therefore, are a relevant therapeutic target. In this...
Reading the immune clock: a machine learning model predicts mouse immune age from cellular patterns
Aging is accompanied by profound alterations in the immune system; yet, an accurate prediction of immunological age remains challenging. While transcriptomic approaches have yielded insights into immune aging, protein-level profiling and machine learning-based prediction tools remain underdeveloped. Here, we employ mass cytometry to analyse murine splenic CD45⁺ immune cells across various age groups, profiling the expression of 30 protein markers and monitoring age-related immune changes. By...
Cross-regulation of [2Fe-2S] cluster synthesis by ferredoxin-2 and frataxin
Iron-sulfur (Fe-S) clusters are essential metallocofactors that perform a multitude of biological functions^(1-7). Their synthesis is tightly regulated and defects in this process lead to severe diseases^(8-10), such as Friedreich's ataxia, which is caused by defective expression of frataxin (FXN)^(11). However, the underlying mechanisms that regulate this process remain unclear. Here we show that efficient Fe-S cluster assembly requires a fine-tuned balance in the ratio of FXN and ferredoxin-2...