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Ammonia Metabolism in the Aging Liver: Emerging Mechanistic Insights
During aging, hepatic structural, metabolic, and regulatory impairments collectively contribute to the decline of hepatic and systemic function. As a core hepatic physiological process, ammonia metabolism is essential for maintaining systemic nitrogen homeostasis. However, how ammonia metabolism is altered during aging, and whether these changes contribute to hepatic and systemic decline, remain insufficiently understood. In this review, current evidence linking hepatic ammonia metabolism to...
Down-Regulation of TFEB With Defective Autophagy in the Susceptibility of Aging Kidneys to Septic Acute Kidney Injury
Sepsis-associated acute kidney injury (SA-AKI) is a common and devastating disease that has a significantly higher incidence and greater severity in elderly patients, but the molecular basis underlying SA-AKI in the elderly is largely unknown. Recent studies have proved autophagy as an intrinsic protective mechanism against AKI; however, the role and regulation of autophagy in aging kidneys remain unclear. Here we demonstrate that defective autophagy activation in aging kidneys is a key to their...
Mechanistic Study of Platelet Membrane-Coated Resveratrol Nanosystem in Mitochondrial Dysfunction and Endothelial Senescence During Atherosclerotic Lesion Development via FOXM1 Activation
Atherosclerosis (AS) is closely linked to endothelial cell (EC) senescence and mitochondrial dysfunction, which impair vascular repair. Resveratrol (RSV) has antioxidant, anti-inflammatory, and pro-angiogenic effects, but its clinical use is restricted by poor bioavailability. This study aimed to construct a platelet membrane-coated resveratrol nanosystem (PM@RSV NPs) and investigate its mechanism of action in delaying the progression of AS by activating FOXM1 to improve mitochondrial function,...
Chimps and bonobos hug and hold hands just like us
New study suggests ancient origins of reassuring social touch among apes
Daily briefing: Baby <i>T. rex </i>were tiny but deadly
Senescent cells cluster CTCF on nuclear speckles to instruct an alternative splicing program
Moving floors keep buildings from swaying with the wind
Faintest planet ever spotted from Earth has been hiding in plain sight
Don’t let AI steal all the joy: what scientists won’t give up to chatbots
Does China’s latest AI model finally equal US rivals? What scientists think
Seven ways endurance sports have taught me to be a better researcher
Ten years of mapping gene expression in tissues
New hope in the fight against cachexia — cancer’s deadly co-conspirator
Oil and gas drilling is shifting to the deep sea — here’s what is at stake
Are boldness and belligerence related?
Scientists found mystery bacteria inside one of the ocean’s most elusive whales
Scientists studying decades of pygmy sperm whale strandings have uncovered three previously unknown types of Helicobacter bacteria hiding in the animals’ stomachs. All four infected whales showed serious digestive damage, including inflammation, ulcers, scarring, and parasite infestations, although the bacteria were not confirmed as the cause of death.
New molecular map reveals how the flu virus hijacks human cells
Scientists uncovered how influenza A commandeers human cells, including a surprising strategy that dissolves tiny structures in the nucleus and releases proteins the virus may use to reproduce. The detailed molecular map could reveal new drug targets and help researchers study dangerous flu strains such as H5N1.
This food compound may help vaccines work better in older adults
A naturally occurring compound found in foods such as wheat germ, mushrooms, and aged cheese may help older adults build stronger protection after vaccination. In a small pilot trial, researchers gave spermidine supplements to adults over 65 following their third COVID-19 vaccine dose. The biggest improvements appeared among people whose immune systems initially responded poorly, with higher antibody levels and stronger activity against several variants.
Rapid spread of Ebola spurs ‘remarkably’ quick drug and vaccine trials
Pioneering studies are underway to address massive outbreak of rare Bundibugyo virus in the Congo
New antibody drug stops aggressive prostate cancer from spreading
Scientists have developed a fully human antibody that halted the growth and spread of aggressive prostate cancer in preclinical research. Although more testing is needed, the drug’s unusual mechanism could open the door to a safer new treatment for advanced cancer.