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Bilingualism modulates baseline brain-cognition relationships in aging: Evidence from the HABS-HD cohort
Bilingualism has been proposed to confer advantages in cognitive aging, yet the neural mechanisms underlying any such advantages remain debated. In a pre-registered analysis of cross-sectional and longitudinal data from elders in the HABS-HD cohort, we asked whether bilingualism is associated with three measures of brain structure (total brain volume, hippocampal volume and white-matter lesions) and/or moderates the relationship between brain structure and two measures of cognition (executive...
Nuclear medicine-based diagnosis and therapeutic strategies for neurodegenerative diseases: Clinical progress
Neurodegenerative diseases (NDs) are chronic neurological diseases characterized by progressive neuronal loss and pathological protein deposition in specific brain regions. With the deepening of population aging, these diseases have become one of the most serious public health challenges. Due to the high heterogeneity of these disorders and the complex pathogenesis, it brings great challenges to clinical precision diagnosis and treatment. In this context, nuclear medicine molecular imaging...
Two-wave status patterns of handgrip strength asymmetry and low handgrip strength in relation to all-cause mortality in middle-aged and older Chinese adults
Handgrip strength asymmetry (HGSA) and low handgrip strength (LHGS) reflect distinct aspects of muscle health, but their changes over time have been less studied. We examined whether two-wave status patterns of HGSA and LHGS were associated with all-cause mortality in middle-aged and older Chinese adults. We analyzed 8924 participants aged ≥ 45 years from the China Health and Retirement Longitudinal Study. HGSA and LHGS were assessed in 2011 and 2013 and classified as normal at both waves, newly...
Targeting pro-senescent PTGS2(+) macrophages alleviates chondrocyte senescence and osteoarthritis progression
No abstract
Association of a multiple risk factor assessment and intervention program with risk of diabetes: A population-based matched cohort study
CONCLUSIONS: In this population-based cohort study, participation in a low-intensity preventive health program delivered in routine care was associated with a lower incidence of diabetes among older adults. However, the observational study design limits evidence on the intervention's role in the observed association, and more robust evidence is needed. Nevertheless, these findings suggest that scalable, population-wide prevention strategies may complement intensive high-risk approaches in...
Life-Course Adversity, Adult Socioeconomic Position, and Possible Sarcopenia Among Older Adults in Postwar Vietnam
ObjectivesThis study examines how early-life hardship, wartime exposure, military service, and adult socioeconomic position are associated with grip strength-based possible sarcopenia among older adults in postwar Vietnam.MethodsWe analyzed data from the Wave 1 Vietnam Health and Aging Study among 2,166 adults aged 59 and older. Possible sarcopenia was defined using Asian Working Group for Sarcopenia 2019 grip-strength thresholds; survey-adjusted logistic regression models were...
Association of B-Type Natriuretic Peptide With Intrinsic Capacity Trajectories Among Chinese Older Adults
CONCLUSIONS: Elevated and persistent BNP abnormalities are consistently associated with IC decline, supporting BNP as a practical biomarker for early identification of older adults at risk of functional deterioration.
Daily briefing: The first new cat species described by science in a century
RamanOmics decodes the spatial vibrational–molecular architecture of senescence in aging and repair
The chemical fingerprint of cellular senescence
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AI co-scientists are revolutionizing how research is done
China punishes prominent academics exposed by research sleuth
Edible batteries power medical devices in the body
Chemist-aligned retrosynthesis by ensembling diverse inductive bias models
How do I change labs gracefully during my PhD?
Losing your way of life to climate change matters — and we need a way to measure it
Six principles for supporting academic freedom in universities
White House move to seize control of NIH grant decisions upsets senators and scientists
Budget chief Russell Vought reportedly wants more power to veto DEI-related funding
Millions take calcium and vitamin D for bone health. A major review finds little benefit
A sweeping review of more than 153,000 adults found that calcium and vitamin D supplements, alone or together, do little to prevent fractures or falls in most older people. Researchers say the findings challenge routine supplementation for prevention and point instead toward strategies such as balance and resistance exercise.