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CONCLUSION: We propose a comprehensive framework comprising three components: cohort setting, measuring contributing factors, and full assessment. This framework sets the stage for a unified, supranational protocol that harmonizes survey methods across countries, integrates multidisciplinary perspectives, and adopts a longitudinal approach. It would enable larger sample sizes and more robust statistical analyses, allowing researchers to explore complex relationships and derive more accurate...

The aim of this study is to investigate perceptions of aging among Hispanic adults. Fifty participants in Texas and Arkansas were asked to take a short questionnaire including multiple-choice and Likert scale format questions. Individuals 18 and older who identified as Hispanic were included in the study. Counts and frequencies for each response were obtained. Furthermore, an exploratory comparison of responses between younger and middle-aged/older respondents was conducted. According to the...

Aging is associated with a decline in the regenerative capacity of many tissues. Central to this decline is a complex interplay between inflammation and stem cell function. How these two processes are linked and influence regenerative capacity remains unclear. Here, we undertake a comprehensive assessment of age-related changes in the mouse colon at single-cell resolution. A survey of immune and epithelial compartments revealed a hyperactivated inflammatory state in the colon of old mice...

DNA-protein crosslinks (DPCs) are toxic DNA lesions that block all DNA transactions including replication and transcription, and the consequences of impaired DNA-protein crosslink repair (DPCR) are severe. At the cellular level, impaired DPCR leads to the formation of double strand breaks, genomic instability, and cell death, while at the organismal level, it is associated with cancer, aging, and neurodegeneration. Despite its importance, the mechanisms of DPCR at the organismal level are...

Such prescient planning started 50,000 years earlier than thought, study finds

No abstract

Parkinson's disease (PD) is characterised by the progressive degeneration of dopaminergic (DA) neurons in the substantia nigra pars compacta (SNpc). Lewy bodies- the defining neuropathological hallmark of PD-are chiefly composed of aggregated forms of α-synuclein (α-syn). Despite the widespread presence of α-syn pathology, neurodegeneration is often selective, and the mechanisms underlying the vulnerability of specific neuronal populations in PD remain poorly understood. This review critically...

Ferroptosis promotes the progression of Parkinson's disease (PD) through its unique regulatory pathways. Biochanin A (Bioch A) has long attracted the attention of researchers due to its neuroprotective effects. However, whether Bioch A can treat PD by inhibiting ferroptosis and the underlying mechanism remain unclear. This study aimed to investigate whether Bioch A exerts a neuroprotective effect on PD by activating the Sirt1/Nrf2/GPX4 signaling pathway to inhibit ferroptosis. Behavior was...

Chronic systemic inflammation and DNA methylation changes are two major hallmarks of aging, yet their interaction is poorly known. We investigated the relation between circulating inflammatory proteome and epigenetic age acceleration as assessed by DNA methylation in four independent cohorts of different ages and health conditions. Epigenetic age scores known to predict human health span (GrimAge and PhenoAge) were more strongly associated with age-associated inflammatory proteins, frailty, and...

Inundations of pelagic Sargassum plague the tropical Atlantic, with size and impacts steadily increasing to surpass 30 million tons in 2025. Understanding the drivers of Sargassum growth in the so-called Great Atlantic Sargassum Belt is fundamental to developing effective mitigation strategies for affected nations. We present a nonlinear regression model that both explains the seasonal and interannual variability observed between 2011 and 2022 and predicts Sargassum concentrations in 2023 and...

Adipose tissues are highly dynamic in response to environmental temperature changes. During aging, subcutaneous white adipose tissues (WAT) decreases, yet whether this atrophy exacerbates cold stress and triggers systemic aging remains unclear. Here we show that adipocyte-specific expression of the Lmna^(G609G) mutation in male mice leads to progressive WAT atrophy, accelerates aging, and shortens lifespan, whereas female mice remain unaffected. This lipoatrophy exacerbates cold stress,...