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Two-wave status patterns of handgrip strength asymmetry and low handgrip strength in relation to all-cause mortality in middle-aged and older Chinese adults
Handgrip strength asymmetry (HGSA) and low handgrip strength (LHGS) reflect distinct aspects of muscle health, but their changes over time have been less studied. We examined whether two-wave status patterns of HGSA and LHGS were associated with all-cause mortality in middle-aged and older Chinese adults. We analyzed 8924 participants aged ≥ 45 years from the China Health and Retirement Longitudinal Study. HGSA and LHGS were assessed in 2011 and 2013 and classified as normal at both waves, newly...
Targeting pro-senescent PTGS2(+) macrophages alleviates chondrocyte senescence and osteoarthritis progression
No abstract
Association of a multiple risk factor assessment and intervention program with risk of diabetes: A population-based matched cohort study
CONCLUSIONS: In this population-based cohort study, participation in a low-intensity preventive health program delivered in routine care was associated with a lower incidence of diabetes among older adults. However, the observational study design limits evidence on the intervention's role in the observed association, and more robust evidence is needed. Nevertheless, these findings suggest that scalable, population-wide prevention strategies may complement intensive high-risk approaches in...
Life-Course Adversity, Adult Socioeconomic Position, and Possible Sarcopenia Among Older Adults in Postwar Vietnam
ObjectivesThis study examines how early-life hardship, wartime exposure, military service, and adult socioeconomic position are associated with grip strength-based possible sarcopenia among older adults in postwar Vietnam.MethodsWe analyzed data from the Wave 1 Vietnam Health and Aging Study among 2,166 adults aged 59 and older. Possible sarcopenia was defined using Asian Working Group for Sarcopenia 2019 grip-strength thresholds; survey-adjusted logistic regression models were...
Association of B-Type Natriuretic Peptide With Intrinsic Capacity Trajectories Among Chinese Older Adults
CONCLUSIONS: Elevated and persistent BNP abnormalities are consistently associated with IC decline, supporting BNP as a practical biomarker for early identification of older adults at risk of functional deterioration.
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Millions take calcium and vitamin D for bone health. A major review finds little benefit
A sweeping review of more than 153,000 adults found that calcium and vitamin D supplements, alone or together, do little to prevent fractures or falls in most older people. Researchers say the findings challenge routine supplementation for prevention and point instead toward strategies such as balance and resistance exercise.
8 common food additives linked to high blood pressure and heart disease
Common preservatives hiding in processed foods may carry unexpected heart risks, with heavy consumption linked to substantially higher rates of high blood pressure and cardiovascular disease. Researchers identified eight widely used preservatives associated with hypertension, although the observational study cannot prove they were directly responsible.
Accelerated aging as a key mechanism linking diet quality to cardiovascular disease: a prospective mediation analysis in the UK Biobank
We aimed to examine the mediating role of accelerated aging in the association between diet quality and CVD incidence and mortality. Data were obtained from the UK Biobank cohort. Diet quality was evaluated using four established indices: the Healthy Eating Index-2020, the Alternative Healthy Eating Index, the Dietary Approaches to Stop Hypertension index, and the Mediterranean Diet Score. Accelerated aging was assessed by the Phenotypic Age Acceleration and Biological Age Acceleration. Outcomes...