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Scientists discover a surprising clue to why some brains resist Alzheimer’s

1 week 5 days ago
Why do some people stay mentally sharp even when their brains show signs of Alzheimer’s disease? Scientists in the Netherlands may have uncovered an important clue hidden in a rare group of immature brain cells. Researchers discovered that these cells remain present even in people over 80, but their behavior differs dramatically between those who develop dementia and those who remain cognitively healthy.

Mayo Clinic discovers new ways to fight the “zombie” cells that drive aging

1 week 5 days ago
Mayo Clinic scientists have uncovered surprising new insights into “zombie cells,” aging cells that linger in the body and contribute to inflammation and disease. Seven studies reveal why these cells are harmful and identify new strategies for targeting them, including a natural compound found in tomatoes. In aging mice, experimental treatments reduced inflammation and improved physical and brain health. The findings could open the door to therapies that combat some of the biological processes behind aging.

Scientists solve a 30-year mystery behind inflammatory bowel disease

1 week 5 days ago
Scientists have identified a hidden cause of inflammatory bowel disease: antibodies that disable the immune system’s natural ability to control inflammation, potentially explaining severe illness in thousands of patients. The breakthrough also solves a 30-year genetic mystery and could pave the way for more precise diagnoses and targeted treatments.

Histone Modifications at the Intersection of Aging, Neuroinflammation and Metabolism in Alzheimer's Disease

1 week 6 days ago
Aging, neuroinflammation and metabolic dysfunction are tightly intertwined in Alzheimer's disease (AD), but how transient pathological signals become persistent cellular states remains poorly understood. Histone post-translational modifications (PTMs) provide a dynamic interface between extracellular stimuli, cellular metabolism and chromatin state. This Review examines how canonical histone modifications and emerging metabolite-derived acylations regulate inflammatory and stress-responsive...
Junyi Liang