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Carotid plaque vulnerability and circle of Willis anatomy predict ipsilateral brain infarcts and long-term mortality in carotid endarterectomy patients
Cerebral infarcts in carotid artery disease arise from a complex interplay between plaque vulnerability, extracranial vascular burden, intracranial collateral capacity. Although each of these factors has been studied individually, their combined impact on infarct presence, infarct pattern, and long-term outcomes in real-world carotid endarterectomy (CEA) populations remains insufficiently understood. This study aimed to determine how carotid plaque morphology, bilateral carotid stenosis...
Endothelial soluble APP/APLP2 promote heart repair through KIT-mediated angiogenesis
Amyloid precursor protein (APP) gives rise to amyloid-β, a pathological factor in Alzheimer's disease. However, the physiological role of APP and its homolog amyloid precursor-like protein 2 (APLP2), which are also widely expressed outside the nervous system, is largely unknown. Here, we show that endothelial APP and APLP2 are required for postischemia angiogenesis after myocardial infarction (MI). We found that hypoxia induced the endothelial expression of α-secretases, resulting in...
Harnessing the stem cell potential in the human hippocampus to limit cognitive aging
The field of human adult neurogenesis has been controversial despite mounting evidence. The authors propose moving beyond debating the existence of adult neurogenesis and towards discovering strategies to harness endogenous stem cell potential for resilience against cognitive aging.
Skin as a sentinel and modulator of systemic aging: a translational framework for evidence-based gerotherapeutics
Aging is increasingly recognized as a dynamic and potentially modifiable biological process, yet translation of mechanistic discoveries into clinically validated interventions that extend human healthspan remains limited. Because dermatologists can directly observe, sample, and quantify age-related changes in vivo, the skin provides an accessible platform for gerotherapeutic evaluation. As the largest and most environmentally exposed organ, the skin integrates intrinsic hallmarks of aging,...
Workaholism as a neglected risk factor for unhealthy aging: implications for the Semmelweis-EUniWell Workplace Health Promotion Program
Workaholism, also referred to as problematic overworking, has received increasing attention due to its adverse consequences for individuals, families, and organizations. This perspective paper argues that workaholism represents a largely neglected risk factor for unhealthy aging, as sustained exposure to excessive and compulsive work might be associated with an increased risk of cardiometabolic conditions, including hypertension and cardiovascular disease. We further highlight that, despite the...
Developmental constraints mediate the reversal of temperature effects on the autumn phenology of European beech after the summer solstice
Accurate projections of temperate tree growing seasons under climate change require representing developmental constraints that determine tree resource allocation. A phenological 'switch point' after the summer solstice (21 June) has been proposed, with pre-solstice warming advancing autumn phenology and post-solstice warming delaying it. We propose that this switch is flexible and occurs at the compensatory point between early-season development and late-season temperature effects. We performed...
Spermidine Mitigates Immune Cell Senescence and Boosts Vaccine Responses in Healthy Older Adults-A Pilot Study
Older adults are highly vulnerable to infectious diseases, and vaccines are often less effective in this population because of diminished B and T cell memory responses driven by impaired autophagy, immunosenescence, and chronic low-grade inflammation. Spermidine has been shown to counteract immunosenescence and induce autophagy in preclinical models, and its levels decline with age in humans. We conducted a double-blind, randomised, placebo-controlled pilot study in 40 adults over 65 years of...
Immunosenescence and Vaccine Efficacy in Aging: Dynamic Interplay of Gut Microbiota and mTOR Signaling Pathways
Aging significantly impairs vaccine efficacy in older adults, driven by immunosenescence, inflammaging, and disruptions in the gut microbiota-mTOR-immune axis. This review synthesizes current evidence on how aging alters vaccine-induced immune responses through the interplay of gut microbiota dysbiosis and dysregulated mTOR signaling. Age-related microbial diversity declines and reduced short-chain fatty acid (SCFA) production exacerbate inflammation, while heightened mTOR activity suppresses...
Stress impairs your brain’s ability to link memories — dampening insight
Hit a lab project glitch? Thinking about your thesis title like a storyteller can help you focus
AI cracks 80-year-old mathematics challenge — researchers are astonished
Major Ebola outbreak is escalating: what happens next
Neuroflix
Vanishing tongues and life on Mars: Books in brief
Popular weight loss drugs like Wegovy may also target arthritis inflammation
Researchers have discovered that the GLP-1 hormone targeted by drugs like Wegovy is present in very low amounts inside the joints of arthritis patients. That finding suggests high-dose GLP-1 medications could potentially reach the joints and influence inflammation directly, not just help through weight loss. Scientists say this could open the door to a completely new approach to arthritis treatment.
It’s official: Europe physicists plan to build 91-kilometer particle collider
The $19 billion Future Circular Collider would build on results from CERN’s Large Hadron Collider, currently the world’s largest
Meet the microbiologist and science advocate who’s headed to Congress
Jasmine Clark led a March for Science in 2017. She just won a Georgia primary for a safe Democratic House seat
U.S. agencies aren’t ready for the rising cost of making research papers free, report warns
Science agencies could soon face nearly $1 billion publishing bill, Congressional analysts find
“Zombie cells” aren’t always bad and that could transform anti-aging medicine
Scientists are uncovering a surprising truth about aging cells: some may damage the body, while others help protect it. The discovery is fueling a new wave of precision anti-aging therapies aimed at removing only the harmful “zombie” cells without disrupting the body’s natural repair systems.
Scientists discover a two-stage aging process that may cause cancer and arthritis
A new theory suggests many age-related diseases may actually start decades before symptoms appear. Researchers say early-life damage — from infections, injuries, or genetic mutations — can remain hidden until aging weakens the body’s ability to keep it under control. This could explain why conditions like cancer, osteoarthritis, and shingles suddenly emerge later in life.