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Cracking chemistry with quantum simulations
Science, Volume 390, Issue 6777, Page 1002-1003, December 2025.
In Other Journals
Science, Volume 390, Issue 6777, Page 1013-1014, December 2025.
A writing pact
Science, Volume 390, Issue 6777, Page 1074-1074, December 2025.
Challenges and opportunities for quantum information hardware
Science, Volume 390, Issue 6777, Page 1004-1010, December 2025.
A quantum centenary
Science, Volume 390, Issue 6777, Page 996-997, December 2025.
Hexatic phase in covalent two-dimensional silver iodide
Science, Volume 390, Issue 6777, Page 1033-1037, December 2025.
A stoichiometrically conserved homologous series with infinite structural diversity
Science, Volume 390, Issue 6777, Page 1057-1063, December 2025.
Improved solvent systems for commercially viable perovskite photovoltaic modules
Science, Volume 390, Issue 6777, Page 1021-1028, December 2025.
Cell wall patterning regulates plant stem cell dynamics
Science, Volume 390, Issue 6777, Page 1064-1070, December 2025.
High-fidelity human chromosome transfer and elimination
Science, Volume 390, Issue 6777, Page 1038-1043, December 2025.
Semiseparated biphasic bicontinuous dielectric elastomer for high-performance artificial muscle
Science, Volume 390, Issue 6777, Page 1044-1049, December 2025.
Centering disabled perspectives in technology
Science, Volume 390, Issue 6777, Page 989-989, December 2025.
Painting the phylogeny of life
Science, Volume 390, Issue 6777, Page 990-990, December 2025.
What’s the fuss about aluminum in vaccines?
Despite extensive safety record, U.S. health advisers are set to discuss claimed link to asthma
100 years on, quantum mechanics is redefining reality—with us at the center
Increasingly popular theories hold that experimental outcomes really do depend on the observer
Satellite fleets pose problems for space telescopes, too
Proposed “megaconstellations” would contaminate images from telescopes in low-Earth orbit, including Hubble
The therapeutic potential of early exercise in Alzheimer's disease: Focus on the brain-spleen axis
Alzheimer's disease (AD) is the predominant cause of cognitive dysfunction, with global prevalence increasing annually. AD progression is principally driven by the accumulation of amyloid-β (Aβ) and hyperphosphorylated microtubule-associated protein tau (p-Tau), which trigger a subsequent cascade of neuroinflammatory responses within the central nervous system (CNS). This pathological cascade is regulated by reciprocal CNS-peripheral immune crosstalk. The brain-spleen axis has emerged as a...
Laminar organization of pyramidal neuron cell types defines distinct CA1 hippocampal subregions
Investigating the cell type organization of hippocampal CA1 is essential for understanding its role in memory and cognition and its susceptibility to neurological disorders like Alzheimer's disease and epilepsy. Multiple studies have identified different organizational principles for gene expression and how it reflects cell types within the CA1 pyramidal layer including gradients or mosaic. Here, we identify sublaminar gene expression patterns within the mouse CA1 pyramidal layer that span...
The 'silent' brain cells that shape our behaviour, memory and health
No abstract
27-Hydroxycholesterol triggers microglial senescence subsequent to iron over-loading contributes to brain aging, suppressed by Deferoxamine
Brain aging is a major factor in cognitive decline and Alzheimer's disease (AD) progression. Aging-induced microglial senescence critically drives inflammaging and brain aging processes. Nevertheless, the underlying reasons and mechanisms that promote microglial aging remain unclear. This study explores how 27-hydroxycholesterol (27-OHC), a key oxysterol, accelerates brain aging by promoting microglial senescence, iron overload, and neuroinflammation. Clinically, we observed a significant...