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High-dimensional topological photonic entanglement
Science, Volume 391, Issue 6792, Page 1379-1382, March 2026.
Experimental evidence of a liquid-liquid critical point in supercooled water
Science, Volume 391, Issue 6792, Page 1387-1391, March 2026.
SWOT detects dispersive tsunami tied to a near-trench source in the 2025 Kamchatka earthquake
Science, Volume 391, Issue 6792, Page 1368-1372, March 2026.
An Early Miocene ape from the biogeographic crossroads of African and Eurasian Hominoidea
Science, Volume 391, Issue 6792, Page 1383-1386, March 2026.
Cooperation by non-kin during birth underpins sperm whale social complexity
Science, Volume 391, Issue 6792, Page 1355-1360, March 2026.
Population genomics of Anopheles darlingi, the principal South American malaria vector mosquito
Science, Volume 391, Issue 6792, Page 1373-1378, March 2026.
An out of this world buddy movie
Science, Volume 391, Issue 6792, Page 1328-1328, March 2026.
When disease resists diagnosis
Science, Volume 391, Issue 6792, Page 1329-1329, March 2026.
Abnormal behaviors in lab monkeys may reflect a lifetime of stressful experiences
Pacing and hair pulling may develop after multiple experiments, years of relative isolation, and more
Unprecedented footage shows sperm whales joining forces to help a newborn calf
Cetaceans from different families take turns lifting baby whale to surface to breathe
‘Resurrection plants’ bounce back after years of drought. Do they hold lessons for crops?
Plant biologist Jill Farrant hopes “desiccation-tolerant” species can teach her how to make crops more resilient
Hot things can freeze faster than cool ones. Now, this paradox has gone quantum
Unified theory explains Mpemba effect from ice cream to atoms—with implications for faster quantum computing
World’s oldest dog identified at ancient hunter-gatherer site
Bones of 15,800-year-old puppy push confirmed origin of our canine companions back nearly 5000 years
Genes from giant viruses help polar algae survive frigid waters and harsh sunlight
A prior infection may create lasting, beneficial evolutionary change in these hardy microbes
Cellular senescence in neurodegenerative diseases: a bibliometric analysis and mechanistic synthesis linking translational pathways to therapeutic implications
CONCLUSION: Cellular senescence research in NDs (notably AD, PD) shows broad promise from mechanisms to therapy. Future priorities include elucidating tau dysregulation's core role in senescence, developing specific biomarkers and targeted interventions. Senescent microglia are new therapeutic targets. Multi-target senomorphics modulating SASP offer new mechanisms for delaying ND progression. Understanding senescence mechanisms and precise interventions may provide novel ND therapies.
Metabolomic biomarkers enhance 10-year mortality risk calibration and clinical utility in older heart failure patients: A UK Biobank study
CONCLUSION: Integrating metabolic biomarkers with standard clinical characteristics significantly improves model calibration and clinical net benefit for predicting 10-year mortality in older adults with heart failure. This approach highlights underlying mechanisms, such as mitochondrial energy dysfunction and chronic systemic inflammation, providing a practical tool for personalized care planning and targeted interventions.
Astrocytic AEBP1-NPAS3-LIPA pathway coordinates cholesterol homeostasis to regulate Alzheimer's pathology
Astrocytes regulate brain cholesterol homeostasis, but the astrocyte-specific mechanisms disrupted in Alzheimer's disease (AD) are poorly understood. By integrating human bulk transcriptomes with single-nucleus RNA sequencing (RNA-seq), we identified adipocyte enhancer-binding protein 1 (AEBP1) as an astrocyte-enriched factor upregulated in AD. In postmortem human tissue and 5×FAD mice, astrocytic AEBP1 levels rise with age and disease progression. Astrocyte-specific AEBP1 knockdown ameliorates,...
Endogenous ATP-powered nanomotors directing neural stem cell differentiation for Parkinson's disease treatment
Transplantation-free neuron regeneration remains attractive yet unsolved for reversing Parkinson's disease (PD). Here, we present enzyme-driven mesoporous gold nanomotors (Apyrase@Au) that leverage endogenous biochemical energy for spatiotemporally controlled promotion of neural stem cell (NSC) differentiation, without exogenous stem cell transplantation. By catalyzing endogenous adenosine triphosphate (ATP) hydrolysis, Apyrase@Au nanomotors simultaneously generate directional propulsion and...
Tau catalyzes amyloid-β aggregation and toxicity in a polymorph-dependent manner
Interactions between amyloidogenic proteins are emerging as critical drivers of neurodegenerative diseases. Among others, in Alzheimer's disease (AD) and severe forms of chronic traumatic encephalopathy (CTE), codeposition of tau and amyloid-β (Aβ) leads to worsening of clinical outcomes and disease progression. Despite the importance of such heterotypic interactions, the underlying molecular mechanisms have proven challenging to be established. Here, we investigated the direct interaction...
A randomized controlled trial to address a multimodal intervention in the elderly: the effects of the CAMINN study
No abstract