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Agency aims to select teams for milestone-driven competition by year’s end

Scientists found that declining levels of the brain protein Menin may help drive aging, with lower levels in mice linked to inflammation, cognitive decline, weaker bones, and thinner skin. Restoring Menin reversed several age-related changes, while the amino acid D-serine improved cognition, hinting at a potentially intriguing new target for healthy aging.

SWOT is exposing humans’ effects on rivers—and challenging flood prediction models

Ozempic and other GLP-1 medications can improve blood sugar, weight, and cardiovascular health, but researchers found little evidence that they also improve mental health, employment, marriage, or overall well-being. The findings suggest the drugs’ broader life effects may be subtler than their dramatic physical health benefits.

A kimchi-derived bacterium can bind to nanoplastics under gut-like conditions and may help carry them out of the body. In mice, the probiotic more than doubled the amount of nanoplastics detected in feces, pointing to a surprising potential use for microbes from fermented foods.

A natural compound produced by gut bacteria after digesting foods such as pomegranates, walnuts, and berries may help repair and protect the intestinal lining. The discovery reveals a surprising beneficial side of an inflammatory pathway and could inspire more targeted treatments for Crohn’s disease and ulcerative colitis.

Scientists discovered that brain-cell axons may not be smooth tubes as textbooks have shown for more than a century, but instead naturally resemble strings of tiny pearls. Those pearl-like structures can change with neural activity and may help control how quickly electrical signals travel through the brain.

Frailty is a complex geriatric syndrome characterized by age-related declines in physiological function and cognitive reserve. To promote early prevention and intervention, minimally invasive and objective biomarkers that can detect frailty progression are required. We aimed to identify biomarkers associated with frailty progression and to elucidate their relevance to the Japanese version of the Cardiovascular Health Study (J-CHS) criteria, consist of five components (unintentional weight loss,...

Senescence is a key pathomechanism across chronic diseases but also highly heterogeneous. In this study, we demonstrate that high-content imaging and transcriptomics can jointly shed light on senescence in vitro, distinguishing replicative and chemically induced senescence, differentiating from quiescence and characterizing the senolytic response.

Age-related olfactory decline in humans is well-documented, yet the underlying peripheral neural mechanisms remain poorly understood. We investigated age-related olfactory decline across psychophysical, nasal mucosal, and central neural levels in 73 healthy adults across the lifespan. Participants underwent Sniffin' Sticks testing and simultaneous recordings of mucosal electro-olfactograms (EOG) and cerebral chemosensory event-related potentials (CERP) in response to olfactory and trigeminal...

Aging bridges pose significant risks to public safety. Although existing sensing technologies offer a potential solution for structural health monitoring, the high cost and complexity of installing and maintaining sensing systems have limited their scalability and long-term deployment. Here, we present a scalable and cost-effective approach that turns pre-existing telecommunication (telecom) fiber-optic cables into a dense array of dynamic strain sensors to continuously monitor bridges. Using...

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CONCLUSIONS: Higher activity levels and higher day-to-day morning activity variance measured over just two to three mornings differentiate those at higher risk of death and frailty decline, increasing the feasibility of using accelerometry as a digital frailty screening tool.

Toward development of an autologous, induced pluripotent stem cell (iPSC)-based cell therapy for Parkinson's disease (PD), we demonstrate successful, reproducible genomic and transcriptomic qualification of patient-derived dopaminergic neuron precursor cells (DANPCs) across multiple donors. Our analysis includes whole-genome sequencing data from fibroblasts, iPSCs, and DANPCs and the development of NeuriTest, an RNAseq-based bioinformatic analysis of DANPCs designed to predict cell quality based...