Aggregator

GLP-1 drugs like semaglutide—best known for treating diabetes and driving weight loss under the brand names Ozempic and Wegovy—may also deliver a surprising mental health boost. In a massive study tracking nearly 100,000 people over more than a decade, researchers found that these medications were linked to significantly fewer psychiatric hospital visits and sick days.

Drugs designed to clear amyloid beta from the brain—once seen as a promising path to slowing Alzheimer’s—may not actually help patients in any meaningful way, according to a major review of over 20,000 participants. Even more concerning, they may increase the risk of brain swelling and bleeding, sometimes without obvious symptoms.

Architectural and geographic details match historic descriptions of the colonial, centuries-old jungle refuge

Timmy, a humpback whale stranded in Germany 6 weeks ago, was ailing and may already be dead

Coffee doesn’t just energize—it actively reshapes the gut and mind. Researchers found that both caffeinated and decaf coffee altered gut bacteria in ways linked to better mood and lower stress. Decaf even improved learning and memory, while caffeine boosted focus and reduced anxiety. Together, they show coffee works through multiple pathways beyond just caffeine.

A hidden force may be quietly shaping how you feel—and you’d never even know it. Infrasound, an ultra-low-frequency vibration below the range of human hearing, is everywhere from traffic to old buildings. In a small experiment, people exposed to it became more irritable, less engaged, and even showed higher levels of the stress hormone cortisol—despite having no idea it was present. The findings suggest our bodies can “sense” these vibrations without conscious awareness, potentially explaining eerie sensations in places like basements or supposedly haunted buildings.

The brain’s memory center may begin life more like a crowded web than an empty canvas. Researchers discovered that early neural networks in the hippocampus are dense and seemingly random, then become more organized by shedding connections over time. This pruning process creates a faster, more efficient system for linking experiences and forming memories. It challenges the idea that the brain starts from scratch.

A new analysis of the “Boltzmann brain” paradox suggests our memories and sense of reality could, in theory, be random illusions born from cosmic chaos. By uncovering circular reasoning in how physicists think about time and entropy, the study raises fresh doubts about what we can truly know about the past.

Nitric oxide (NO) is a pleiotropic gaseous mediator that regulates tissue homeostasis. At physiological levels, it functions as a precise signaling molecule through soluble guanylate cyclase (sGC) activation and the reversible S-nitrosylation of cysteine residues. However, in the context of aging and fibrosis, oxidative stress disrupts this balance. The increased generation of superoxide (O₂•⁻) anions diverts NO from homeostatic signaling to form peroxynitrite (ONOO⁻), a potent oxidant. This...

Aging, stress-related disorders, and chronic disease are often examined across separate domains-stress physiology, nutrition, psychiatry, and geroscience-despite converging on shared phenotypes of functional decline and reduced resilience. Although adaptive responses to stress are well characterized, why comparable exposures yield sustained resilience in some individuals but progressive dysfunction in others remains insufficiently explained. We propose that the missing unifying constraint is not...

This study examined associations between dietary habits and the risk of developing Cardiovascular Risk Factors, Aging, and Incidence of Dementia (CAIDE)-predicted late-life dementia risk in Korean adults. A total of 5,042 participants aged 40-69 years were included. We assessed associations between dietary patterns-the Mediterranean diet, Mediterranean-DASH Intervention for Neurodegenerative Delay (MIND) diet, Korean Healthy Eating Index (KHEI), and Empirical Dietary Inflammatory Index...

Vitamin K2 is a fat-soluble vitamin that has been reported to exhibit significant anti-stress activity. Anti-stress properties are considered to be closely associated with lifespan extension. Therefore, we investigated the effects of vitamin K2 on the lifespan and stress resistance of Caenorhabditis elegans, as well as the underlying mechanisms. In the present study, we found that the effects of Vitamin K2 on C. elegans are concentration-dependent. High concentrations (10 μM) of Vitamin K2 are...

Scientists have discovered a way to help the brain clean itself of harmful Alzheimer’s plaques by activating its own support cells. By increasing a protein called Sox9, researchers were able to boost the activity of astrocytes, star shaped cells that help maintain brain health. In mice that already showed memory problems, this approach reduced plaque buildup and preserved cognitive function over time.

Free-living amoebae are emerging as a global health concern, fueled by warming temperatures and outdated water systems. While many are harmless, some can cause deadly infections and even protect other dangerous microbes. Their ability to survive heat and disinfectants makes them especially hard to control. Scientists say improved surveillance and water treatment are urgently needed.

Life's Essential 8 (LE8) provides a multidimensional framework to assess cardiovascular health (CVH) in aging populations. The objective of this study was to describe LE8 component scores and their variation by age, sex, and psychosocial factors in middle-aged and older adults from Cádiz, Spain. Cross-sectional data were analyzed from 495 adults aged 50-79 years (59.4% women; 34.7% ≥ 65 years). LE8 scores were calculated following American Heart Association guidelines. Group comparisons used...

UVB-induced lens epithelial cell (LEC) senescence is among the important factors involved in the pathogenesis of age-related cataract (ARC). This study aimed to investigate the anti-aging effect of metformin (Met) and to elucidate the molecular mechanisms underlying this effect. RNA sequencing, nontargeted metabolomics analysis and network pharmacology were conducted. The expression of senescence indicators (P53 and P21^(Cip1)) and senescence-associated β-galactosidase (SA-β-gal) activity were...

CONCLUSIONS: A self-administered online geriatric screening tool adapted from the ICOPE framework is feasible, acceptable, and effective in detecting GSs in primary care. The high prevalence of GSs highlights the urgent need for scalable digital solutions. Integrating online screening into primary care workflows could facilitate early identification, optimize resource use, and promote healthy aging in resource-constrained settings.

CONCLUSIONS: Our findings suggest that the use of white noise can result in improving sleep quality and may be helpful in reducing fatigue in community-dwelling older adults and can be recommended as an low effort, low-cost and safe strategy to enhance sleep and reduce fatigue in older individuals.

Cancer-associated cachexia (CAC) is a multifactorial wasting syndrome characterized by progressive loss of fat and lean mass, systemic inflammation, and poor therapeutic responsiveness. While brown adipose tissue (BAT) is traditionally considered a protective, energy-dissipating organ, its qualitative remodeling in CAC remains poorly characterized.Here, we demonstrate that CAC induces a senescent conversion of BAT, marked by thermogenic failure, fibrosis, inflammation, and acquisition of a...