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CONCLUSION: Symptoms are highly prevalent among older men and significantly associated with lower HrQoL and pain, tiredness, depression, and anxiety were the most impactful. These findings underscore the importance of targeted symptom screening and management to promote healthy aging and well-being.

BACKGROUND: This manuscript presents the study protocol of the PRICA-POWFRAIL randomized controlled trial. Frailty and pre-frailty are major predictors of functional decline and dependency in older adults, yet the implementation of personalized, scalable, and clinically interventions in primary care remains limited. This protocol describes the methodological design and planned evaluation of a lifestyle education programme and an individualized exercise-prescription algorithm aimed at improving...

No abstract

CONCLUSION: The impacts of different interventions on frailty in older adults exhibited outcome-specific variations. Combined interventions were most effective in improving frailty scores, demonstrating potential synergistic effects between physical exercise and nutrition, while nutritional supplementation showed the most significant benefit for gait speed. Multicomponent exercise alone also produced significant improvements in frailty scores and physical performance. These findings suggest that...

Alzheimer's disease (AD) is the prevailing cause of age-associated dementia worldwide. Current standard of care relies on antibody-based immunotherapy. However, antibody-based approaches carry risks for patients, and their effects on cognition are marginal. Increasing evidence suggests that T cells contribute to AD onset and progression. Unlike the cytotoxic effects of CD8^(+) cells, CD4^(+) T cells capable of regulating inflammation show promise in reducing pathology and improving cognitive...

Alzheimer's disease (AD) is the prevailing cause of age-associated dementia worldwide. Current standard of care relies on antibody-based immunotherapy. However, antibody-based approaches carry risks for patients, and their effects on cognition are marginal. Increasing evidence suggests that T cells contribute to AD onset and progression. Unlike the cytotoxic effects of CD8^(+) cells, CD4^(+) T cells capable of regulating inflammation show promise in reducing pathology and improving cognitive...

Previous experimental reports of long-range interactions in ionic liquids (ILs) stand in contradiction with theoretical predictions and numerical simulations. To provide insights into the literature discrepancies regarding the experimental ranges of electrostatic screening, claimed with orders of magnitude larger, the interactions between pairs of mica and borosilicate surfaces confining ILs are investigated by two complementary advanced Surface Force Apparatuses. Regardless of differences in...

A hallmark of Alzheimer's disease (AD), the most common form of dementia, is the progressive accumulation of amyloid-beta (Aβ) peptides across distinct brain regions. Anti-Aβ antibodies (Aβ-Abs) targeting specific Aβ variants are essential tools for AD research, diagnostics, and therapy. The monoclonal antibodies Aducanumab, Lecanemab, and Donanemab have recently been approved as the first disease-modifying treatments for early AD, highlighting the clinical importance of their exact binding...

No abstract

With increasing global life expectancy, the prognostic significance of kidney function in centenarians and supercentenarians should be clarified. The conventional estimated glomerular filtration rate (eGFR) threshold of < 60 mL/min/1.73 m² may not accurately reflect chronic kidney disease (CKD) in this population, highlighting the need for age-adapted definitions. This study investigated the association of kidney function with all-cause mortality across three age groups. Data from the Tokyo...

Thirteen-year-old Okinawa Institute of Science and Technology hopes to become a global science leader

University votes to consider ending all studies at Oregon National Primate Research Center. But cost and feasibility are still in doubt

Orbiting satellites will monitor changes in the stratosphere and on the planet’s surface