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We investigated stressful adversities older adults face, examined whether older men and women experience them differently, assessed the stressfulness of these events and studied their relationship to resilience-the ability to overcome adversity. This cross-sectional study included 1179 respondents from the Helsinki Birth Cohort Study, born between 1934 and 1944. At a mean age of 75 years, respondents reported the most stressful adversity in the past five years, its perceived stressfulness and...

Mobility decline with aging is a major health concern, associated with a higher risk for disability. Despite the prevalence of gait slowing in elderly adults, this issue has not been adequately addressed. The central nervous and skeletal muscle systems are key regulators of gait speed. However, direct molecular communication along the brain-muscle axis and their interactions in mobility resilience remain poorly studied. Extracellular vesicles (EVs) have emerged as a key player in long-distance...

The accumulation of senescent cells contributes to age-related inflammation and heightened susceptibility to viral infection. The mechanisms by which cellular senescence and aging exacerbate virus-associated diseases remain poorly understood. Here we show that innate antiviral immunity is progressively impaired with aging in mice, in parallel with systemic accumulation of senescent cells. Mechanistically, senescent cells suppress innate antiviral response mostly via four senescence-associated...

New tool could help researchers probe how models “unlearn” sensitive training material

Curiosity rover finds what may be the first direct evidence that Mars once had a thick atmosphere

Attacks have destroyed or damaged a wide range of academic and commercial research centers

This article aims to comprehensively analyze the vascular factors in Alzheimer's Disease (AD), particularly the changes in the carotid arteries, and their complex correlations with hippocampal atrophy and cognitive function. Besides the traditional β-amyloid protein (Aβ) and Tau protein hypotheses, vascular factors are increasingly regarded as crucial factors in the development of AD. This article systematically reviews the roles of cerebral blood flow perfusion changes and micro-infarctions in...

The accumulation of amyloid β (Aβ) protein in the brain is a central pathological hallmark of Alzheimer's disease (AD). This process has become a major focus of interdisciplinary research and a critical target in drug development. Aβ is produced through the proteolytic processing of amyloid precursor protein (APP) by a group of enzymes known as secretases. They belong to different protease classes and operate through proteolytic cleavage of the peptide bond through several catalytic hydrolysis....

Gait speed is a robust marker of health in older adults and is associated with cognition, yet few studies have examined this in the oldest-old and if there are differences by cognitive domain. We examined the association between gait speed and cognition across three domains in individuals aged 90 + , considering differences by gender and device use. Then, 502 participants were included from the LifeAfter90 Study. Baseline gait speed (meters/second) was measured using the 4-meter walk test. The...

CONCLUSIONS: SHARED delivers a comprehensive, multidimensional framework for social health and provides strong multi-cohort evidence of its importance for cognitive ageing and dementia. Findings highlight the need for improved social health measurement and further work to disentangle its mechanisms and bidirectional links with cognitive ageing and dementia.

The lymphatic system is essential for maintaining interstitial fluid balance, supporting immune surveillance, and clearing metabolic waste, yet its role in ageing has only recently come into focus. With age, lymphatic vessels and lymphoid organs undergo structural and functional decline, leading to impaired transport, disrupted immune cell trafficking, and chronic low-grade inflammation. These changes contribute to systemic inflammaging and are increasingly implicated in cardiovascular disease,...

CONCLUSIONS: This study presents a comprehensive multimodal, cell-type-resolved atlas of the human heart, providing a foundation for understanding human cardiac gene regulation across the human lifespan and in cardiac diseases.

Action cancellation declines with age, contributing to impairments in executive function and overall motor performance. While age-related deterioration of reactive inhibition (stopping an action in response to an external signal) is well-established, less is known about how ageing affects proactive inhibition (preparatory mechanisms which increase the chance that an action can be successfully stopped). This study examined how proactive and reactive inhibitory processes, assessed via changes in...

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Chronic stress (CS) exacerbates anxiety and hyperglycemia, emerging as a key risk factor for type 2 diabetes, yet the mechanism remains unclear. Here, we found that CS induces hyperglycemia and enhanced amygdaloid astrocytic senescence in mice. The amygdaloid astrocytic senescence was mediated by the reduction of hexokinase 2 (HK2) driven by pre-B cell leukemia homeobox transcription factor 1 (PBX1). The astrocytic Hk2 deletion mice and amygdala-specific astrocytic Hk2 knockdown mice both...