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Towards a systems-level view of the microtubule cytoskeleton and its functions in physiology and disease
Microtubules are well-researched components of the cytoskeleton, yet we lack a holistic understanding that bridges molecular and cellular details with the broader functions of the microtubule cytoskeleton in development, ageing and disease. For example, how microtubule properties and functions are affected by tubulin post-translational modifications, disease-related mutations or variation of the microtubule lattice remains unexplored. In this Roadmap, we argue that integrating various...
Lifelong dietary interventions selectively reverse age-associated circulating microRNA upregulation in a time-dependent manner in female MMTV-TGF-α mice
Breast cancer is among the leading causes of cancer mortality worldwide, with aging as a major risk factor. Caloric restriction (CR) is a well-established non-pharmaceutical intervention that extends healthspan and delays tumorigenesis, yet the systemic molecular mechanisms remain elusive. Both chronic and intermittent CR influence metabolic homeostasis, but their long-term effects on circulating miRNAs in breast cancer predisposition are unclear. Here, we examined how chronic and intermittent...
An in vivo resource of age-regulated C. elegans intestinal secretory-pathway proteins highlights secreted enzymes associated with lifespan regulation
Secreted proteins are essential to modulate homeostasis in the extracellular space and facilitate communication to distal cells or tissues. Yet, the identity and functional importance of extracellular proteins in aging have been understudied. Here we use proximity labeling followed by quantitative proteomics to systematically characterize proteins along the intestinal secretory pathway in C. elegans, focusing on secreted proteins. We identify intestine-secreted proteins that are modulated with...
Beyond wrinkles
Can the skin microbiome shape healthy aging?
Disruption of sphingolipid metabolism promotes tau seeding through endolysosomal membrane rigidification and rupture
Endolysosomal dysfunction is a hallmark of Alzheimer's disease and related tauopathies, yet underlying mechanisms remain poorly understood. This study investigates the role of sphingolipid metabolism in maintaining endolysosomal membrane integrity and its impact on tau aggregation and toxicity in Caenorhabditis elegans and human cell culture models. Fluorescence recovery after photobleaching and C-Laurdan dye imaging revealed that silencing sphingolipid metabolism genes reduced endolysosomal...
Daily briefing: Glacier collapse caused Nepal’s deadly flash flood
Why are El Niños getting stronger? 1,000-year-coral record points to climate change
The Roman telescope is about to take planet-hunting to the next level
Glacier collapse caused Nepal’s deadly flash flood — a sign of things to come?
‘Robot Olympics’ reveal humanoids’ rapid progress — and flaws
Animal-microbe partnerships date back to the dawn of complex life
A solution to the mystery of the missing neutrinos
Women face bans on research underground — here’s how to modernize the system
Recent strengthening of eastern Pacific ENSO in the last millennium paleorecord
Science, Ahead of Print.
Smart nanoparticles light up brain cancer and destroy what surgery misses
Scientists created smart nanoparticles that can both illuminate hidden glioblastoma cells during surgery and destroy microscopic cancer left behind afterward. In mice, the treatment prevented recurrence and led to 100% survival at 60 days, though it has not yet been tested in humans.
Scientists discover a brain “brake” that can shut down chronic pain
Researchers discovered a brain-based “brake” that can shut down chronic nerve pain in mice by calming an overactive pain circuit. Targeting this system more precisely could one day lead to powerful pain relief without affecting opioid receptors throughout the entire body.
Key brain circuit regulating hibernation found at last
Discovery in hamsters suggests path toward inducing hibernation in mammals that don’t do it naturally
Climate change is strengthening El Niño, coral records suggest
1000-year archive from the Galápagos portends greater weather disruptions from the Pacific climate cycle
Dreams of making drugs and tissues in space get closer to reality
Maturing techniques and cheaper launches fuel microgravity research—and hopes of orbital manufacturing
Scientists may have found a shortcut to calorie restriction’s anti-aging benefits
Moderate calorie restriction lowered an immune protein called C3 that appears to help drive chronic inflammation as the body ages. Blocking the same protein reduced age related inflammation in mice, raising the possibility that future treatments could mimic some benefits of calorie restriction without severe dieting.