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Metabolomic signatures of extreme old age: findings from the New England Centenarian Study
The New England Centenarian Study (NECS) provides a unique resource for the study of extreme human longevity (EL). To gain insight into biological pathways related to EL, chronological age and survival, we used an untargeted serum metabolomic approach (> 1400 metabolites) in 213 NECS participants, followed by integration of our findings with metabolomic data from four additional studies. Compared to their offspring and matched controls, EL individuals exhibited a distinct metabolic profile...
The relationship between oral health and active aging among the elderly in rural China: the chain mediating effect of intergenerational support and social isolation
No abstract
Individual and combined associations of physical activity and cognitive function with all-cause mortality in older men and women: a prospective analysis of the German National Cohort (NAKO)
No abstract
Cognitive improvement by non-pharmacological electrical stimulation modalities in mild cognitive impairment: a protocol for systematic review and network meta-analysis
CONCLUSION: This study will synthesize evidence from multiple studies on various electrical stimulation therapies for improving cognitive function in patients with mild cognitive impairment, thereby providing a diverse body of evidence to support clinical decision-making by physicians and optimization of treatment strategies for patients.
Retraction: Corrigendum: Identification of cerebral metal ion imbalance in the brain of ageing Octodon degus
[This retracts the article DOI: 10.3389/fnagi.2017.00134.].
Retraction: Identification of cerebral metal ion imbalance in the brain of aging Octodon degus
[This retracts the article DOI: 10.3389/fnagi.2017.00066.].
Senescence-Driven Remodeling Defines an Aggressive and Immunomodulatory Subtype of Endometriosis
Endometriosis is a benign yet invasive disease characterized by ectopic endometrial growth and immune remodeling. While emerging evidence implicates cellular senescence in disease progression, the underlying mechanisms remain largely undefined. In this study, we identified marked heterogeneity in senescence across ectopic lesions and observed that P21-activated kinase 4 (PAK4) was consistently upregulated in senescent cells. Mechanistically, senescence induced PAK4 expression, which in turn...
Daily briefing: Suck-up chatbots can encourage real-life rudeness
Eye drops made from pig semen deliver cancer treatment to mice
Motherhood derails women’s academic careers — these data reveal how and why
Briefing Chat: ‘Zombie cells’ resurrected with new genes
Giants of the deep and the wonder of space: Books in Brief
Sunken Soviet nuclear submarine’s radioactive release
Huge lung-cancer screening campaign boosts early diagnosis
These small African antelopes may help mpox spread
Researchers find evidence that duikers, hunted and eaten across sub-Saharan Africa, can harbor the deadly virus
Two years after it emerged, ‘cow flu’ is still circulating—and baffling scientists
Researchers still aren’t sure how H5N1 influenza spreads between cows and from farm to farm
Long-standing volcanic eruption theory might be backward
Eruptions could be triggered when bubbles vanish into magma—not when they burst out
Myeloid cell nuclear differentiation antigen (MNDA) is an interferon-inducible regulator of myelopoiesis. Potential role in the myeloid-biased aging process
Aging is a myeloid-biased process, i.e., the differentiation of myeloid cells increases, while the lymphoid lineage declines. Cellular senescence increases the secretion of inflammatory mediators which skew hematopoiesis toward myeloid cell generation. Myeloid cell nuclear differentiation antigen (MNDA) is a type-1 interferon (IFN)-inducible factor which is mainly expressed in the cells of the granulocyte-monocyte lineage, especially it is enriched in M2 macrophages and myeloid-derived...
Testicular aging revisited: Current understanding of mechanisms and emerging interventions
Male reproductive aging is a complex physiological process characterized by progressive deterioration in spermatogenesis, hormonal imbalance, and increased susceptibility to infertility and genetic disorders. This review comprehensively summarizes the pivotal molecular mechanisms underlying testicular aging, with emphasis on mitochondrial dysfunction, oxidative stress, DNA damage, autophagy impairment, chronic inflammation, cellular senescence, and dysregulated apoptosis. Accumulating evidence...
The application of ultrasound sarcopenia index in sarcopenic population
CONCLUSION: We showed that increased USI values are associated with sarcopenia. This study shows USI as a sensitive, non-invasive marker for sarcopenia classification, supporting its use in clinical screening and monitoring of muscle changes in older adults.