Skip to main content

Aggregator

Association between cagemate number and risk of death in mice: a time-varying covariate analysis using Cox frailty models

2 weeks ago
Social housing is desirable for the health and well-being of laboratory mice, as social interactions with conspecifics influence both behavioral and physiological outcomes. Although group housing benefits social species, it can introduce variability in mortality outcomes, and raise welfare concerns, particularly with the emergence of aggression or fluctuating cage densities. Despite this, few studies have evaluated how changes in the number of living cagemates over time are associated with...
Thirupathi R Mokalla

Knockdown of the fly spliceosome component Rbp1 (orthologue of SRSF1) extends lifespan

2 weeks ago
Biological regulation is an intricate process involving many layers of complexity, including at the RNA level. Alternative splicing is crucial in the regulation of which components of a protein-coding gene are spliced into a translatable mRNA. During ageing, splicing becomes dysregulated, and alternative splicing is implicated in disease and known anti-ageing treatments such as dietary restriction (DR) and mTOR suppression. In prior work, we have shown that DR and mTOR suppression modulate the...
Dan J Hayman

Multilevel regulation of skeletal muscle ferroptosis in aging: sex- and exercise-dependent effects on histological, molecular, and genetic markers

2 weeks ago
Ferroptosis, an iron-dependent form of regulated cell death, is increasingly recognized as a key contributor to aging-associated skeletal muscle degeneration and dysfunction. However, the interactive effects of aging, sex, and exercise modality on ferroptosis regulatory markers at the histological, protein, and gene expression levels remain poorly understood. Male (n = 23) and female (n = 23) mice aged 7 (young) and 17 (aged) months were assigned to sedentary control, voluntary wheel running, or...
Fujue Ji

The efficacy of reminiscence therapy on the cognition of older patients with cognitive impairment or dementia: a meta-analysis based on regulatory factors

2 weeks ago
CONCLUSION: RT is an effective intervention for improving cognition, memory, depression, and quality of life in older adults with cognitive impairment or dementia. Patient age, intervention frequency, and setting are potential moderators of its cognitive efficacy, providing actionable insights for optimizing clinical RT protocols.
Shan Wang

Household fuel use, social engagement, and cognitive decline in older Chinese adults: a prospective cohort study based on CHARLS

2 weeks ago
CONCLUSION: Coal use increases the risk of cognitive decline, whereas higher social engagement is protective; these influences operate independently without evidence of interaction. Reducing household reliance on coal while promoting meaningful social participation may represent complementary strategies to preserve cognitive health in aging populations.
Afei Qin

ACSS2 upregulation enhances neuronal resilience to aging and tau-associated neurodegeneration

2 weeks ago
Epigenetic mechanisms, including histone acetylation, regulate learning and memory and underlie Alzheimer's disease and related dementia (ADRD). Acetyl-CoA synthetase 2 (ACSS2), an enzyme generating acetyl-CoA, locally regulates histone acetylation and gene expression in neuronal nuclei. This regulatory mechanism may be a promising target for therapeutic intervention in neurodegenerative diseases. Previously, we showed that systemic ACSS2 knockout mice, although largely normal in physiology,...
Naemeh Pourshafie

Highly sensitive chemiluminescence imaging of misfolded proteins in neurodegenerative models

2 weeks ago
Protein misfolding in the brain is a key pathological hallmark of neurodegenerative diseases. Optical imaging of misfolded proteins in disease models is essential for elucidating etiology and early diagnosis. However, developing specific optical imaging probes for each misfolded protein is time-consuming and challenging, leaving many pathological targets without effective detection tools, especially for in vivo imaging. Here, we present a dual-mode chemiluminescence strategy that enables both...
Biyue Zhu

The interplay between biomolecular assembly and phase separation

2 weeks ago
Many biological functions and dysfunctions rely on two fundamental processes, molecular assembly and the formation of condensed phases such as biomolecular condensates. Condensed phases generally form via phase separation, while molecular assemblies are clusters of molecules of various sizes, shapes, and functionality. We developed a theory that relies on thermodynamic principles to understand the interplay between molecular assembly and phase separation. We propose two prototypical classes of...
Giacomo Bartolucci

ACSS2 upregulation enhances neuronal resilience to aging and tau-associated neurodegeneration

2 weeks ago
Epigenetic mechanisms, including histone acetylation, regulate learning and memory and underlie Alzheimer's disease and related dementia (ADRD). Acetyl-CoA synthetase 2 (ACSS2), an enzyme generating acetyl-CoA, locally regulates histone acetylation and gene expression in neuronal nuclei. This regulatory mechanism may be a promising target for therapeutic intervention in neurodegenerative diseases. Previously, we showed that systemic ACSS2 knockout mice, although largely normal in physiology,...
Naemeh Pourshafie

Systematic identification of single transcription factor perturbations that drive cellular and tissue rejuvenation

2 weeks ago
Cellular rejuvenation through transcriptional reprogramming is an exciting approach to counter aging. Using a fibroblast-based model of human cell aging and Perturb-seq screening, we developed a systematic approach to identify single transcription factor (TF) perturbations that promote rejuvenation without dedifferentiation. Overexpressing E2F3 or EZH2, and repressing STAT3 or ZFX, reversed cellular hallmarks of aging-increasing proliferation, proteostasis, and mitochondrial activity, while...
Janine Sengstack

Deciphering the Transcriptomic Signatures of Aging Across Organs in Mice

2 weeks ago
Aging, a major risk factor for numerous diseases, is associated with significant transcriptional changes across organs. However, the age of onset, extent of transcriptomic changes and how they unfold are not fully understood. We performed bulk RNA sequencing on eight organs (brain, heart, kidney, liver, lung, skeletal muscle, spleen, and testis) from male C57BL/6J mice across much of the murine lifespan covering 3-, 5-, 8-, 14-, 20- and 26-month-old animals. Our analysis revealed that...
Sarah Morsy

Context-Dependent Roles of ANGPTL2-Mediated Inflammaging in Tissue Homeostasis, Pathological Tissue Remodeling, and Longevity

2 weeks ago
Chronic inflammation is a key driver of aging-related diseases, obesity-associated metabolic disorders, and tumor progression. Aging and obesity contribute to the accumulation of senescent cells, which secrete senescence-associated secretory phenotype (SASP) factors that promote tissue remodeling and chronic inflammation. Here, we investigated the pathological roles of angiopoietin-like protein 2 (ANGPTL2), a potential SASP factor, in a mouse model of high-fat diet-induced premature aging. We...
Shinsei Yumoto