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1 week 6 days ago
Science, Volume 390, Issue 6773, Page 587-588, November 2025.
Corinne Simonti, and Jesse Smith, Madeleine Seale, Marc S. Lavine, Jesse Smith, Corinne Simonti, Stella M. Hurtley, Mattia Maroso, and Phil Szuromi

Extreme warming of Amazon waters in a changing climate

1 week 6 days ago
Science, Volume 390, Issue 6773, Page 606-611, November 2025.
Ayan Santos Fleischmann, Fabrice Papa, Stephen K. Hamilton, John Melack, Bruce Forsberg, Adalberto Val, Walter Collischonn, Leonardo Laipelt, Júlia Brusso Rossi, Bruno Comini de Andrade, Bruna Mendel, Priscila Alves, Maiby Bandeira, Lady Custódio, Maria…

Platforms of power

1 week 6 days ago
Science, Volume 390, Issue 6773, Page 580-580, November 2025.
Simson L. Garfinkel

A probabilistic histological atlas of the human brain for MRI segmentation

2 weeks ago
In human neuroimaging, brain atlases are essential for segmenting regions of interest (ROIs) and comparing subjects in a common coordinate frame. State-of-the-art atlases derived from histology^(1-3) provide exquisite three-dimensional cytoarchitectural maps but lack probabilistic labels throughout the whole brain: that is, the likelihood of each location belonging to a given ROI. Here we present NextBrain, a probabilistic histological atlas of the whole human brain. We developed artificial...
Adrià Casamitjana

Lymphoid gene expression supports neuroprotective microglia function

2 weeks ago
Microglia, the innate immune cells of the brain, play a defining role in the progression of Alzheimer's disease (AD)¹. The microglial response to amyloid plaques in AD can range from neuroprotective to neurotoxic². Here we show that the protective function of microglia is governed by the transcription factor PU.1, which becomes downregulated following microglial contact with plaques. Lowering PU.1 expression in microglia reduces the severity of amyloid disease pathology in mice and is linked to...
Pinar Ayata