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Science, Volume 392, Issue 6798, Page 612-616, May 2026.

Science, Volume 392, Issue 6798, Page 624-628, May 2026.

Science, Volume 392, Issue 6798, Page 585-585, May 2026.

Science, Volume 392, Issue 6798, Page 584-584, May 2026.

Science, Ahead of Print.

Science, Ahead of Print.

A new twin study suggests your genes may play a bigger role in your future success than your upbringing. Researchers found that IQ, which is largely genetically influenced, strongly predicts education, career, and income. Even twins raised in the same household diverged based on genetic differences. The findings hint that life outcomes may be more hardwired than many people expect.

Scientists in Sweden have taken a major step toward a potential cure for type 1 diabetes by developing a more reliable way to create insulin-producing cells from human stem cells. These lab-grown cells not only respond strongly to glucose but were also able to restore blood sugar control when transplanted into diabetic mice.

Project has brought income and electricity while protecting wide swaths of tropical forest

MIT neuroscientists have uncovered a surprising secret hidden in the adult brain: millions of “silent synapses,” dormant connections that lie in wait until new learning calls them into action. Once thought to exist only in early development, these inactive links make up about 30% of synapses in the adult cortex and can be rapidly activated to form fresh memories.

Science, Ahead of Print.

A recent study by Bieri et al. shows that exercise elevates hepatic glycosylphosphatidylinositol-specific phospholipase D1 (GPLD1), which cleaves endothelial tissue-nonspecific alkaline phosphatase (TNAP) to rejuvenate cerebrovascular signaling, enhance cognition in aging, and attenuate Alzheimer's-related pathology. This liver-to-brain enzymatic axis positions hepatokines as potent mediators of exercise-induced neuroprotection, which redefines systemic metabolism as a driver of brain...

Blood biomarkers are rapidly becoming established for Alzheimer's Disease (AD) diagnosis. However, there is a need for more scalable tools to reach the 99% of individuals with early cognitive impairment who are not seen in specialist healthcare services. A recent study validated a capillary blood sampling technique to detect the p-tau217 and GFAP biomarkers. Here we used our PROTECT research study to show that these biomarkers, when collected using self-administered fingerprick tests, correlate...

No abstract

A recent study by Bieri et al. shows that exercise elevates hepatic glycosylphosphatidylinositol-specific phospholipase D1 (GPLD1), which cleaves endothelial tissue-nonspecific alkaline phosphatase (TNAP) to rejuvenate cerebrovascular signaling, enhance cognition in aging, and attenuate Alzheimer's-related pathology. This liver-to-brain enzymatic axis positions hepatokines as potent mediators of exercise-induced neuroprotection, which redefines systemic metabolism as a driver of brain...

The Six1 (SIX homeobox 1) gene is pivotal in renal and pulmonary development and differentiation. Its dysregulation is implicated in oncogenesis and tumor progression via enhancing cell proliferation and delaying senescence. However, whether or how it functions in the natural aging have not been investigated. To answer this question, we generated Six1 gene knockout mice using CRISPR-Cas9 technology. All Six1 biallelic knockout mice died at birth since the underdeveloped lungs. In Six1^(+/-)...

The aging process exhibits tissue-specific characteristics, yet its underlying mechanisms remain poorly understood. While it is widely accepted that a reduction in blood vessels in hard tissues contributes to aging, such as in osteoporosis, the vascular changes driving soft tissue aging and degeneration remain unclear. Here, by integrating single-cell transcriptomics and light-sheet imaging, we uncover a striking infiltration of type H-like blood vessels and an aging-specific Coch^(+) cell...

Developing sustainable adhesives with simultaneous high adhesive strength and excellent work of debonding remains challenging. Here, strong, ultra-tough, environmentally reliable, and recyclable polyurethane adhesives are reported, utilizing a multiscale engineering approach. The multiscale structure employs a top-down design philosophy to merge the advantages of both thermoplastic and thermosetting systems, integrating multi-level organizations including macroscale dual-length dynamic...

Incentives modulate voluntary movement, yet the circuitry channeling these signals into motor output remains unclear. Classical models emphasize a closed-loop circuit (CLC) linking dorsal putamen (PUTd) with the motor cortex, but this pathway is anatomically segregated from affective processing regions. Anatomical and clinical evidence point to an alternative: an open-loop circuit (OLC) from ventral putamen (PUTv) that may route affective signals to the motor cortex. Here, we conducted two...

Red pulp macrophages (RPMs) remove senescent erythrocytes from the circulation and recycle their iron for erythropoiesis. The development of RPMs is guided by signals from the microenvironment, which promote expansion and tissue adaptation through the induction of transcription factors, including Spi-C and PPARγ. Here, we show that infection with the nematode Nippostrongylus brasiliensis or treatment with IL-33 results in the accumulation of activated group 2 innate lymphocytes (ILC2s) in the...