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Early-Life Climbing Stratifies the Metabolome and Mortality Risk in Genetically Identical Flies

2 weeks ago
Studies in laboratory organisms typically minimize all environmental and genetic variation other than the intervention of interest. In aging studies, these highly controlled conditions have yielded profound insights into aging. But even within isogenic cohorts of lab animals in controlled environments, we observe substantial variation in lifespan. Here we exploited the climbing behavior of Drosophila to study variation in mortality among isogenic populations in a controlled environment. We show...
Benjamin R Harrison

Human Umbilical Cord Plasma Metabolomics Uncover Potential Metabolites for Combating Aging

2 weeks ago
Human umbilical cord blood (HUCB) exhibits distinct characteristics compared to adult blood, offering significant potential for medical applications, particularly in antiaging therapies. However, the metabolic profile of HUCB relative to adult blood remains poorly understood. Moreover, the specific metabolites within HUCB that confer antiaging properties have yet to be identified. Here, we conducted an untargeted metabolomic analysis comparing cord plasma and adult plasma. Our results reveal a...
JiaYu Liu

In Science Journals

2 weeks 1 day ago
Science, Volume 390, Issue 6776, Page 895-897, November 2025.
Michael Funk, and Julie S. Haas, Phil Szuromi, Jelena Stajic, Corinne Simonti, Angela Hessler, Leoma Bere, Michael A. Funk, Yevgeniya Nusinovich, Caroline Ash, Yury Suleymanov, Ekeoma Uzogara, Sacha Vignieri, Jesse Smith, Leslie Ferrarelli, and Melissa…