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Science, Volume 392, Issue 6795, Page 317-323, April 2026.

Science, Volume 392, Issue 6795, Page 289-295, April 2026.

Science, Volume 392, Issue 6795, Page 296-300, April 2026.

Science, Volume 392, Issue 6795, Page 285-288, April 2026.

Science, Volume 392, Issue 6795, Page 261-261, April 2026.

Science, Volume 392, Issue 6795, Page 262-262, April 2026.

Science, Volume 392, Issue 6796, Page 371-378, April 2026.

Mineral grains show Colorado River filled a basin at the canyon’s head millions of years ago

Newly discovered bacterial defense system challenges genetic code’s central dogma

Researchers encode the tiny hepatitis D virus in an early step toward “quantum genomics”

Ancient DNA reveals “massive” genetic shifts tied to rise of farming, wheels, and metal tools

Gaining precise control of gene expression is crucial in biomedical applications. However, spatiotemporal precision remains challenging. Here, we present a remotely controlled in vivo gene switch responsive to electromagnetic fields (EMFs) that enables precise spatiotemporal activation of target genes. We uncovered the EMF-inducible gene switch activation mechanism via a CRISPR-Cas9 screen, identifying cytochrome b5 type B (Cyb5b) as an essential mediator likely acting as an EMF sensor. The...

Multiple system atrophy (MSA) is a rare, age-related neurodegenerative disease that shares clinical and pathological features with Parkinson's disease (PD) but presents a more devastating disease course. To elucidate the distinct cellular pathophysiology, we performed single-nucleus RNA sequencing on postmortem striatal brain tissue from 7 MSA and 12 PD patients, and 10 non-neurological cases. Here, we show significant compositional differences in astroglia and microglia subtypes, while...

Dissecting biological pathways highlighted by Mendelian gene discovery has provided critical insights into the pathogenesis of Parkinson's disease (PD) and neurodegeneration. This approach ultimately catalyzes the identification of potential biomarkers and therapeutic targets. Here we identify PSMF1 as a gene implicated in parkinsonism and childhood neurodegeneration. We find that biallelic PSMF1 missense and loss-of-function variants co-segregate with phenotypes from early-onset PD to perinatal...

Immunosenescence drives organismal aging, yet quantifying its heterogeneity to uncover therapeutic targets remains challenging. We construct a human immune aging clock from single-cell multi-omics data of nearly 1.2 million human peripheral blood mononuclear cells from 230 individuals, precisely mapping immune aging. T cell (TC) transcriptomes are key predictors, revealing hallmarks such as naive cell loss and clonal contraction. This framework identifies the transcription factor RUNX1, whose...

Regulated cell death-processes such as apoptosis, pyroptosis, necroptosis, and ferroptosis-is essential for development, tissue homeostasis, and response to infection or cellular stress. The proteins involved in regulated cell death necessarily possess powerful and potentially damaging activities, including proteolysis, membrane pore formation, DNA cleavage, and inflammatory pathway activation. Traditionally, these activities drive cell death. However, sub-lethal activation of these pathways...

B cell development is one of the best-understood processes within the immune system. Coordination between transcriptional programs and antigen receptor assembly determines B cell fate, diversifies the antibody repertoire, and allocates specificities to the best-suited subsets. This enables B cells to respond to a wide variety of challenges, which, when encountered, can lead B cells to seemingly converge upon a common fate: the antibody-secreting plasma cell. Yet, as we discuss in this review,...

Gaining precise control of gene expression is crucial in biomedical applications. However, spatiotemporal precision remains challenging. Here, we present a remotely controlled in vivo gene switch responsive to electromagnetic fields (EMFs) that enables precise spatiotemporal activation of target genes. We uncovered the EMF-inducible gene switch activation mechanism via a CRISPR-Cas9 screen, identifying cytochrome b5 type B (Cyb5b) as an essential mediator likely acting as an EMF sensor. The...

CONCLUSION: This bibliometric survey defines the age and focus of the research into HGPS, with published research being highly concentrated and collaborative and showing possible future research directions in regenerative therapy and epigenetic control. Although the modern knowledge about the progeria condition has grown significantly, there is still a significant drawback of the psychosocial research, prolonged therapy trials, and equity in research participation globally. The results thus...

CONCLUSION: HIIT and plasma from young trained rats may offer protective or restorative benefits against sarcopenia. These findings highlight the therapeutic potential of combining or alternating exercise and plasma-based strategies in elderly populations.