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Common gene variant that increases risk of lupus may protect against viruses
An evolutionary trade-off may have helped a mutation linked to auto-immune disease persist in human populations
Aerobic exercise and the gut-brain axis in Alzheimer's disease: Mechanistic perspectives, evidence appraisal, and future directions
Alzheimer's disease (AD) is a multifactorial neurodegenerative disorder in which neuroinflammation, vascular dysfunction, metabolic disturbances, and impaired tissue resilience contribute to disease progression. Aerobic exercise is a widely applicable lifestyle intervention that has been increasingly investigated in AD; however, the mechanisms linking peripheral exercise adaptations to brain outcomes remain incompletely understood. This review evaluates the potential contribution of gut-derived...
Predicting conversion from mild cognitive impairment to Alzheimer's disease: A systematic review of deep learning models for early-stage disease classification
CONCLUSION: Deep learning models hold considerable potential for predicting MCI-to-AD conversion, yet substantial barriers remain to their translation into routine clinical practice. Greater emphasis on longitudinal analysis, intelligent multimodal fusion, and interpretable architectures is essential for clinical impact. Future research should prioritize the development of diverse, multicenter datasets, advancement of explainable AI (XAI) techniques, and the design of personalized time-to-event...
Transmembrane Protein PTCHD4 Is a Novel Regulator of Cellular Senescence and Age-Related Pathologies
Cellular senescence is a key driver of age-related pathologies. Our study focuses on PTCHD4, a transmembrane protein with previously undefined physiological functions in aging processes. We found that PTCHD4 expression was increased across multiple cellular senescence models and showed an age-associated increase in mouse tissues and human lung transcriptomic datasets. Functionally, PTCHD4 deficiency attenuated senescence progression, whereas its overexpression promoted this process. In vivo,...
Parental longevity and polygenic longevity scores in relation to ageing-related factors in a population of 70-year-olds followed over six years: The Gothenburg H70 Birth Cohort Study
As societies age, a deeper understanding of ageing-related factors that contribute to longevity is needed. We therefore investigated possible longevity factors (social, medical, and biological) in relation to parental longevity (PL) and polygenic longevity scores (PGLSs). We examined 1126 70-year-olds from the Swedish population-based Gothenburg H70 Birth Cohort study in 2014-2016 (response rate 72%), with follow-up in 2019-2022 (response rate 77.6%). Comprehensive examinations included...
Ex vivo bone marrow subniches influence the fate of human antibody-secreting cells
Long-term humoral immunity relies on long-lived plasma cells in the bone marrow (BM). However, the processes governing plasma cell transport, positioning, and longevity within the BM niche remain poorly understood, especially in humans. Most existing knowledge comes from mouse studies or limited human-based models, which makes translating findings to human biology challenging. Here, we introduce a physiologically relevant human bone marrow-on-a-chip (hBMOC) model to investigate the behavior and...
Mitochondrial Haplotype Shapes the Trajectory of Ovarian Aging in Genetically Heterogeneous Rats
Ovarian aging leads to permanent reproductive senescence and systemic hormonal changes that predispose women to age-associated comorbidities. Despite these observations, the intrinsic mechanisms driving age-related ovarian decline are poorly defined. Mitochondrial DNA (mtDNA) mutations and instability are strongly associated with aging; however, it remains unknown if naturally occurring mitochondrial genetic variation influences the trajectory of ovarian aging. To address this, we compared two...
The Secretome Derived From Human Umbilical Cord Mesenchymal Stem Cells Improves Skin Photoaging by Enhancing Mitophagy to Inhibit the cGAS-STING Pathway
Ultraviolet (UV)-induced skin photoaging is driven by cellular senescence and chronic inflammation. Although the secretome (SCT) derived from human umbilical cord mesenchymal stem cells (hUC-MSC SCT) exhibits regenerative potential, its role in combating photoaging remains to be elucidated. In this study, we show that SCT markedly ameliorates photoaging in UV-exposed mice, restoring epidermal barrier function, dermal collagen integrity, senescence-associated markers, and systemic inflammatory...
Daily briefing: Skeleton teeth show evidence of the earliest known habitual drug use
NSF moves to overhaul funding approach in line with White House priorities
Fibronectin mediates APOE4-driven blood–brain barrier dysfunction in Alzheimer’s disease
European Innovation Council support for healthy aging biotechnology
Osteoporosis affects millions: could modified cells rebuild their bones?
People trust scientists seen to be ‘on their side’, UK study finds
Briefing Chat: The Bunsen burner myth that turns out to be just hot air
Successful early-career scientists rely on network of mentors
El Niño goes viral — and scientists learn what makes people care about the climate
Social science studies may promise anonymity, but participant identities often lurk in public data
One-fifth of data sets intended to support replication breached privacy standards, study finds
Too much light at night may quietly reshape your heart
Nighttime light exposure was linked to thicker, stiffer heart chambers and early signs of reduced heart function in a study of more than 11,000 people. The findings suggest that keeping bedrooms darker could be an overlooked strategy for protecting the heart.
Scientists find signs of extreme aging and youth in the same 117-year-old
A remarkably detailed study of Maria Branyas, who lived past 117, reveals that extreme longevity may involve both intense aging and powerful biological protection at the same time. Researchers found signs of advanced aging, but also low inflammation, beneficial gut bacteria, protective genetic features, and a biological age younger than her chronological age. Because she avoided major disease, the study offered a rare look at aging itself rather than the illnesses that often accompany it.