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Patients with idiopathic pulmonary fibrosis (IPF) are highly vulnerable to respiratory virus infections, but the cellular mechanisms linking fibrotic remodeling to impaired local antiviral defense remain unclear. Here, we investigated how cellular senescence shapes the response of patient-derived healthy (HLF) and IPF primary lung fibroblasts to influenza A virus (IAV) infection. Transcriptomic profiling identified infection as the driver of gene expression in both DNA damage-induced senescent...

INTRODUCTION: Easy-to-Read (E2R) formatting is widely recommended to improve reading accessibility, yet whether its typographic and structural features benefit visual processing and comprehension across the adult lifespan remains unclear.

CONCLUSION: Social engagement appears to be a critical pathway to health, even if sedentary. Nonetheless, natural spaces are chosen environments for a range of OOH activities. We recommend neighbourhoods be designed with multifunctional natural spaces to encourage mobility during OOH trips, supporting ageing-in-place.

Genome aging refers to age-related acquisition and expansion of de novo mutations in somatic cells, and is now increasingly viewed as a central driver of organismal aging. Loss of X chromosome (LOX), the state in which one X chromosome (ChrX) is missing, represents the most common genetically inferred type of acquired mutation in women. Recent technological advancements, along with the growing availability of large-scale cohorts for association studies, have provided powerful new insights into...

X-ray experiments reveal cubic crystals that could complicate the picture of the inner core

Researchers estimate climate change is responsible for two-thirds of the deaths

A natural compound extracted from a medicinal plant has shown surprising promise against rheumatoid arthritis. In rats, it reduced joint swelling, protected cartilage, and calmed the immune responses responsible for chronic inflammation. Scientists discovered that the compound works by targeting a specific protein and restoring balance to fatty acid metabolism, revealing a previously underexplored way to fight the disease.

A simple, steroid-free procedure could offer lasting relief for people struggling with carpal tunnel syndrome, potentially helping them avoid surgery. In a clinical trial involving 63 patients, researchers found that ultrasound-guided hydrodissection, which uses fluid to free a compressed nerve in the wrist, provided longer-lasting improvements in pain, numbness, and hand function than traditional steroid injections.

Scientists stress need for further study of Shamonda virus but say there’s no cause for alarm

Researchers analyzing nearly 150,000 Reddit posts uncovered unexpected symptom reports linked by users to unapproved versions of retatrutide, including increased appetite, sleep disturbances, and elevated heart rates. The findings differ from clinical trial results and highlight how AI could help identify potential drug safety signals that warrant further investigation.

Tam Dao, who investigated foreign attempts to obtain U.S.-funded research, now has a grant to determine the extent of the threat

A massive study of more than 460,000 Americans found that ultra-processed foods were not associated with increased colorectal cancer risk overall, challenging a widely held assumption. While processed meat was linked to higher cancer incidence, ultra-processed whole grains and dairy products were associated with lower incidence.

Scientists have uncovered an unexpected danger lurking inside cells: too much RNA can damage the structures responsible for producing energy. A new study found that excess RNA, including the normally essential messenger RNA (mRNA), can directly disrupt mitochondria without relying on the immune system. The discovery could help explain how viral infections and certain aging-related diseases damage cells.

A new study tracking 13 astronauts suggests that the human heart may be surprisingly well equipped for a journey to Mars, especially with regular exercise during spaceflight. Researchers found that astronauts' hearts adapted to months of weightlessness and handled simulated Martian gravity without major problems, offering new hope for future missions to the Red Planet.