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Daily briefing: Ovaries start a second job after menopause
Meta-analysis of DNA methylation aging signatures in 17 human tissues
Network-driven discovery of repurposable drugs targeting hallmarks of aging
Inside the new political screening that’s stalling NIH grants
Europe’s record heatwave: does the continent have a new climate?
I study World Cup penalty shoot-outs: they say a lot about the psychology of performance under pressure
CRISPR’s next act: the companies editing the epigenome to treat disease
Briefing Chat: What tickling a chimpanzee can tell us about the evolution of speech
The surprising career parallels between footballers and researchers
The poetry of twilight and the awe-inspiring magic of eclipses: Books in brief
Venezuela’s double earthquake struck faults scientists had flagged
Centuries of strain had built up on faults in the region, making them overdue for a major rupture
NASA’s cheapest missions deliver less scientific bang for the buck, study finds
Analysis of 90 missions suggests midpriced spacecraft produce the most science per dollar
Engineers cram 100 billion transistors onto a microchip
Advance nearly doubles chip density, but also highlights the challenge of sustaining historic trend
Why have papers by one of history’s most famous physicists been retracted?
Springer Nature has removed two studies by Max Planck. A bot may be to blame
This common vitamin deficiency can mimic normal aging
Vitamin B12 is needed in microscopic amounts, but a shortage can have major effects on health and energy. The vitamin was first linked to a lifesaving liver treatment for pernicious anemia nearly 100 years ago. Today, researchers are finding that B12 may also help keep cellular powerhouses called mitochondria functioning properly. This could explain why some people experience fatigue and brain fog even before traditional signs of deficiency show up.
FDA-approved drug may finally help immunotherapy defeat rare liver cancer
Researchers found that a rare liver cancer evades immunotherapy by luring immune T cells away from the tumor and trapping them in nearby fibrous tissue. An FDA-approved drug called AMD3100 freed those T cells to attack the cancer, significantly improving the effectiveness of immunotherapy in tumor samples.
Scientists discover how a single cell builds a brain with 170 billion cells
How does a single cell build a brain with billions of precisely organized neurons? Researchers suggest that brain cells use their lineage—their cellular family tree—as a kind of positional map. Cells that come from the same ancestor stay near one another, helping the brain organize itself without relying solely on chemical signals.
They knew the pill was fake but their memory still improved
Healthy older adults experienced measurable improvements in memory, physical performance, and stress after taking placebo pills for just three weeks. The most surprising finding was that the placebo often worked even when participants knew the pills were completely inactive.
Disrupted brain functional network topology and potential network reorganization in early-stage Parkinson's disease with probable REM sleep behavior disorder
CONCLUSION: Early PD + pRBD exhibit specific and more severe neurofunctional network impairment pattern. Characterized by more significantly disrupted neurofunctional network topology and widespread functional connectivity abnormalities across multiple brain networks, with potential functional network reorganization. These functioning abnormalities may serve as imaging biomarkers for this clinically malignant subtype and provide potential neurobiological mechanism for understanding its poorer...
From plastics to pathology: The neurodegenerative impact of Bisphenol-A on Alzheimer's disease
Bisphenol-A (BPA), a ubiquitous component of polycarbonate plastics and epoxy resins, has emerged as a significant environmental risk factor for neurodegenerative diseases, particularly Alzheimer's disease (AD). It is widely detected in the environment and humans due to its extensive use in plastics and epoxy resins for consumer products such as bottles, containers, and tableware. This review synthesizes current evidence on the molecular and cellular mechanisms by which BPA exposure may...