Aggregator
What Changed Your Mind? Influencers of Older Adults Changing Decisions About Aging-In-Place Versus Long-Term Care
BACKGROUND: As individuals experience age-related changes, such as cognitive decline or hospitalizations, their ability to live independently at home may be impacted. Decision-making and planning are essential in order to support successful aging-in-place (AIP), which is defined as continuing to live in one's home and community. Despite making plans at one single time-point, prior research has demonstrated that decision-making among older adults is not stagnant.
Clonal hematopoiesis of indeterminate potential (CHIP) in cerebromicrovascular aging: implications for vascular contributions to cognitive impairment and dementia (VCID)
Vascular contributions to cognitive impairment and dementia (VCID) represent a major public health challenge in the aging population, with age-related cerebromicrovascular dysfunction playing a critical role in its development. Understanding the mechanisms underlying cerebromicrovascular aging is crucial for devising strategies to mitigate this burden. Among the key hallmarks of aging, genomic instability and genetic heterogeneity have emerged as significant drivers of age-related diseases....
Sleep disorders increase the risk of dementia, Alzheimer's disease, and cognitive decline: a meta-analysis
Sleep disorders, particularly insomnia and obstructive sleep apnea, are increasingly implicated as significant contributors to cognitive decline, dementia, and neurodegenerative diseases such as Alzheimer's disease (AD) and vascular cognitive impairment and dementia (VCID). However, the extent and specificity of these associations remain uncertain. This meta-analysis evaluates the impact of common sleep disorders on the risk of developing dementia and cognitive decline. A comprehensive search of...
Uncovering the impact of loneliness in ageing populations: a comprehensive scoping review
CONCLUSIONS: Loneliness and social isolation among community-dwelling older adults are complex issues with profound implications for physical, mental, and social well-being. Addressing these challenges requires integrative approaches that consider individual, relational, and contextual factors. Further longitudinal and standardized research is needed to improve our understanding of the long-term impacts and effectiveness of interventions to mitigate these issues.
Association between fractures and health status among independent older adults: insights from a suburban cohort in Japan
CONCLUSIONS: This study utilized a relatively large and highly representative sample of community-dwelling residents to identify factors associated with fractures in independent older adults. Even in independent older adults who were not certified as requiring long-term care, fractures were significantly associated with a decline in multiple health domains. These findings provide valuable insights that can inform efforts to promote healthy aging and reduce care dependency.
Living in poverty is associated with gene expression changes in immune cells
Social factors influence health outcomes and life expectancy. Individuals living in poverty often have adverse health outcomes related to chronic inflammation that affect the cardiovascular, renal, and pulmonary systems. Negative psychosocial experiences are associated with transcriptional changes in genes associated with complex traits. However, the underlying molecular mechanisms by which poverty increases the risk of disease and health disparities are still not fully understood. To bridge the...
Identifying PDAP1 as a Biological Target on Human Longevity: Integration of Mendelian Randomization, Cohort, and Cell Experiments Validation Study
Identifying factors affecting lifespan, including genes or proteins, enables effective interventions. We prioritized potential drug targets and provided insights into biological pathways for healthy longevity by integrating Mendelian randomization, cohort, and experimental studies. We identified causal effects of tissue-specific genetic transcripts and serum protein levels on three longevity outcomes: the parental lifespan, the top 1% and 10% extreme longevity, utilizing Mendelian randomization...
The multiple mediating roles of depression and grandchild care in the relationship between social participation and cognitive function among middle-aged and elderly Chinese: an empirical study based on CHARLS 2020 data
CONCLUSION: Social participation not only directly improves cognitive function but also indirectly enhances it by reducing depression and increasing grandchild caregiving engagement among middle-aged and elderly individuals. However, while the mediating effect of grandchild care is statistically significant, its effect size remains relatively small, suggesting that its overall contribution to cognitive function should be interpreted with caution. In contrast, depression demonstrates a more...
Editorial: Targeting the aging mitochondria: mechanisms, methods, and therapeutic strategies
No abstract
Longest human transplant of pig kidney fails
In latest xenotransplant test, Towana Looney’s body rejects gene-edited organ after more than 4 months
Energy Department cuts university overhead rates to 15% on research grants
Sudden move mirrors NIH cap on “indirect” costs that was ruled illegal
Daily briefing: Mysterious Taiwan fossil is Denisovan
NIH cuts triggered a host of lawsuits: <i>Nature</i>’s guide to what’s next
Liquids in a glass recover a graceful shape even after being shaken
Mystery of medieval manuscripts revealed by ancient DNA
Pre-symptomatic Parkinson’s disease blood test quantifying repetitive sequence motifs in transfer RNA fragments
Author Correction: Sulfide-rich continental roots at cratonic margins formed by carbonated melts
Structural pathway for PI3-kinase regulation by VPS15 in autophagy
Science, Volume 388, Issue 6743, April 2025.
A neuroimmune circuit mediates cancer cachexia-associated apathy
Science, Volume 388, Issue 6743, April 2025.
Rules of engagement for condensins and cohesins guide mitotic chromosome formation
Science, Volume 388, Issue 6743, April 2025.