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As existing drugs falter because of resistance, the world gets a backup—but hard choices loom on how to use it

The group’s latest strategy emphasizes consultation, lacks spending pledges

Filter-feeding flying reptile was likely devoured by a dinosaur during the early Cretaceous

Arachnids build large lookalikes to ward off predators

The development of effective interventions for neurodegenerative disorders, such as posterior cortical atrophy (a visual Alzheimer's variant), remains to be a significant clinical challenge. We introduce a computational framework using convolutional neural networks (CNNs) as in silico models to simulate visual system degeneration and evaluate intervention strategies. By modeling controlled synaptic decay and comparing three distinct retraining approaches, random data (control), accuracy-based,...

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Compared to individuals carrying two copies of the ε4 allele of apolipoprotein E (APOE), ε2 homozygotes have an approximate 99% reduction in late-onset Alzheimer's disease (AD) risk. Here we develop a knock-in model that allows for an inducible 'switch' between risk and protective alleles (APOE4s2). Gene expression and proteomic analyses confirm that APOE4s2 mice synthesize E4 at baseline and E2 after tamoxifen administration. A whole-body allelic switch results in a metabolic profile resembling...

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