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Daily briefing: Caffeine might reduce dementia risk and slow cognitive decline
What can I do if my idea has been plagiarized?
How to rescue the aid industry: focus on conflict prevention, not just relief
Tree rings and salt lakes give clues about ancient rainfall
Lab morale got you down? Try a handbook
Public-speaking tips from the experts: what scientists can learn from comics, musicians and actors
China’s biotech boom: why the nation must collaborate to stay ahead
Dozens of researchers will move to France from US following high-profile bid to lure talent
Marine protection in the Azores: a triumph for conservation and sustainability
Publishing less won’t save the research system
Preserving water under megacities is crucial — and urgent
Internet blackout: Iran’s academic shutdown
Snapping shrimp use headgear to protect their brains from shock waves
Unusual “hood” is the first known biological armor that protects against traumatic brain injury
How did ancient Vietnamese people get such black smiles?
Iron salt toothpaste darkened pearly whites
Deep-coverage single-cell metabolomics enabled by ion mobility-resolved mass cytometry
Current single-cell metabolomics approaches are limited by insufficient sensitivity, robustness and metabolite coverage. We present an ion mobility-resolved mass cytometry technology that integrates high-throughput single-cell injection with ion mobility-mass spectrometry for multidimensional metabolomic profiling. Ion mobility-enabled selective ion accumulation and cell superposition-based amplification strategies substantially enhance sensitivity, robustness and overall analytical performance....
Author Correction: Zbtb7a suppresses prostate cancer through repression of a Sox9-dependent pathway for cellular senescence bypass and tumor invasion
No abstract
Synaptic aging and neurodegeneration: the role of synaptic vesicle dynamics and neurotransmitter imbalance
Synaptic aging is a core manifestation of brain aging arising from the convergence of fundamental biological aging processes, including genomic instability, loss of proteostasis, mitochondrial dysfunction, oxidative stress, and chronic low-grade inflammation. As highly energy-dependent and protein-rich sites of neuronal communication, synapses are particularly vulnerable to age-associated molecular stress. Accumulating evidence indicates that age-related impairments in synaptic vesicle...
Exploring service demands of community-embedded elderly care based on the Kano model: a cross-sectional study in Hefei, China
CONCLUSIONS: This study highlights a shift in elderly needs from basic care to personalized and ongoing health management. Community-embedded care should prioritize must-be and one-dimensional attributes while addressing the diverse needs of older adults with varying self-care abilities to better support aging in place.
Prevalence of symptoms and their association to health-related quality of life among older men in Sweden - a cross-sectional study
CONCLUSION: Symptoms are highly prevalent among older men and significantly associated with lower HrQoL and pain, tiredness, depression, and anxiety were the most impactful. These findings underscore the importance of targeted symptom screening and management to promote healthy aging and well-being.
Viability of an educational program for lifestyle changes and an algorithm for the derivation of exercise programs in older people at risk of dependency at primary care: PRICA-POWFRAIL study protocol
BACKGROUND: This manuscript presents the study protocol of the PRICA-POWFRAIL randomized controlled trial. Frailty and pre-frailty are major predictors of functional decline and dependency in older adults, yet the implementation of personalized, scalable, and clinically interventions in primary care remains limited. This protocol describes the methodological design and planned evaluation of a lifestyle education programme and an individualized exercise-prescription algorithm aimed at improving...