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Niemann-Pick disease type C (NPC) is a rare autosomal recessive disorder characterized by progressive neurodegeneration, primarily caused by a functional defect in NPC1 resulting from gene mutations. NPC1, a lysosomal transmembrane protein, acts as a transporter of cholesterol from the lysosome to the endoplasmic reticulum, and its dysfunction results in the intracellular accumulation of unesterified cholesterol. Although microgliosis with accumulated cholesterol has been reported in NPC, the...

Emergency department (ED) length of stay (LOS) is associated with adverse outcomes and increases with age, but the extent to which this reflects differences beyond triage acuity is unclear. Emergency department (ED) length of stay (LOS) is associated with adverse outcomes and increases with age, but the extent to which this reflects differences beyond triage acuity is unclear.We conducted a retrospective cohort study of adult ED visits at a tertiary hospital in Hungary between 2016 and 2023 (n =...

Immunosenescence, the progressive aging of the immune system, is characterized by changes in immune cell composition and function that increase susceptibility to disease. However, how biological sex shapes immune aging at the cellular level remains poorly understood. Here, we analyze single-cell RNA sequencing data from the peripheral blood mononuclear cells of 982 female and male donors across adulthood. We find that aging drives sexually dimorphic compositional and transcriptional changes,...

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Several chemotherapeutics induce cancer cells to senescence, a persistent growth-arrest state associated with poor cancer prognosis. Relevant features in cancer cell biology, such as phenotypic plasticity and intercellular variability, are poorly understood for senescent cells (SnCs). This study examined the morphofunctional heterogeneity and dynamics of glioblastoma cells induced to senescence by Temozolomide (TMZ), focusing on pro-survival mechanisms, including autophagy and anti-apoptotic...

Changing family structures, nuclearization and urbanization are reshaping the socialization and support networks of older adults. Smaller families and migration reduce direct care and engagement opportunities, impacting health and functional ability in the growing aging population. The study explored social networks and perceived social support for older adults in rural and urban Chengalpattu, Tamil Nadu, through 33 in-depth interviews (22 older adults and 11 caregivers). Using the Convoy Model...

CONCLUSIONS: Integrated community-based rehabilitation programs that combine physical activity with intentional social participation, when delivered alongside existing formal lifelong learning programs, offer multidimensional benefits for older adults and may promote more inclusive and participatory approaches to aging.

The extracellular matrix (ECM) is crucial in building the extracellular environment and translating extracellular information into biochemical signals that sustain tissue functions. Fibulin-5 (Fbln5) is a multifunctional ECM protein essential for forming elastic fibers and regulating cellular functions by binding to integrins. Although fibulin-5 expression decreases with age in human skin, its functional implications, particularly in epidermal stem cell regulation, remain largely unexplored....

Salidroside, a phenolic compound derived from Rhodiola rosea L., has been widely utilized in cosmetics and medicine for its anti-melanogenic properties. However, its role in collagen regeneration during skin aging remains unclear. In this study, we investigated the effects of salidroside on collagen synthesis and explored its underlying mechanisms in a murine model of skin aging. Administering salidroside (20, 40, and 80 mg/kg) orally for 28 days significantly increased dermal thickness,...

To investigate the protective effects of Nvshi Oral Liquid on skin aging and oxidative stress in 4-vinylcyclohexene diepoxide (VCD)-induced menopausal rats and Ultraviolet B (UVB)-irradiated HaCaT cells. VCD-induced menopausal rats and UVB-damaged HaCaT cells under low-estrogen conditions were established. Nvshi Oral Liquid was administered at low (2%), medium (6%), and high (10%) concentrations. Cell viability, Reactive Oxygen Species (ROS) levels, antioxidant enzymes (superoxide dismutase...

CONCLUSIONS: DART provides a novel solution to AE reporting challenges faced by aging and serious illness researchers. While its design centers on seriously ill older adults, DART can likely be applied to research in any population and intervention type not regulated by the FDA. Future pilot testing will inform implementation.

BACKGROUND: Healthy aging is a key public health priority in Hong Kong. The Healthy Aging Questionnaire, originally developed and validated in Singapore for older adults, is a concise tool for assessing multiple dimensions of healthy aging.

CONCLUSION: Psychiatric comorbidity is associated with earlier AD onset and reduced lifespan; however, post-diagnosis survival appears to be largely determined by AD progression itself.