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Non-cell autonomous control of presynaptic remodeling by the hypothalamic autophagy-NPY axis
Macroautophagy/autophagy is a critical cellular degradation pathway essential for neuronal proteostasis and synaptic function. Its decline with aging is associated with synaptic dysfunction and reduced circuit resilience. NPY (neuropeptide Y), a highly abundant brain neuropeptide, has emerged as an important regulator of autophagy and aging-related processes. In Drosophila, the NPY-family peptide sNPF modulates age-related changes in presynaptic architecture via non-cell autonomous mechanisms....
A locus coeruleus-centric framework for novelty, salience, and gamma oscillations: implications for neurostimulation, aging, and disease
Neuromodulation techniques in the gamma frequency range, such as chronic 40 Hz sensory stimulation, have gained attention for their potential to impact and preserve cognitive function in the context of neurodegenerative disorders such as Alzheimer's disease (AD). This hypothesis and theory article aims to examine the overlap in biological phenotypes between gamma stimulation techniques and to propose a theoretical mechanism of action that may help to inform future empirical investigations. In...
Stereological sampling-based estimates of dopaminergic and cholinergic neuron numbers in young adult and aged male and female Fischer 344 × Brown Norway F1 hybrid rats
Age is the primary risk factor for neurodegenerative disorders such as Parkinson's disease and Alzheimer's disease, which are characterized by profound loss of midbrain dopaminergic neurons and basal forebrain cholinergic neurons, respectively. In addition, loss of these neurons can occur even in "normal" (i.e., non-pathological) aging, and as a result there is growing recognition of the value of aged animals in studying both normal aging and age-related neurodegenerative disease. The Fischer...
Role of Sociodemographic Variables in the Association Between Physical Performance and Balance Disorders in Older Adults
CONCLUSION: Physical performance impairment is strongly associated with balance disorders among older adults, and this relationship is influenced by sociodemographic factors. These findings suggest that sociodemographic characteristics should be considered when evaluating the relationship between physical performance and balance disorders in older adults.
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Treat biological databases as infrastructure, not projects
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Medieval Europe was battered with 16 catastrophic floods in just 2 years
The intense deluges, never before documented, represent the highest number of back-to-back extreme weather events in the past 700 years
NIH lifts ban on funding research in South Africa
Researchers who study HIV, tuberculosis, and other infectious disease in the country welcome policy change
A therapy that “rewrites” childhood memories can ease fear of failure
Childhood criticism can leave people carrying a fear of failure long into adulthood, but new research suggests those emotional patterns may be surprisingly flexible. Young adults who revisited painful memories through imagery-based therapy showed lasting reductions in fear, guilt, sadness, and stress.