Aggregator

Breaking the silence on late-life depression: uncovering the drivers of help-seeking in Turkiye's ageing population

2 weeks ago
CONCLUSION: The results achieved in this study indicate that among older adults experiencing depression, women, those with higher educational levels, and those with existing illnesses are more likely to seek psychological support. Based on these results, it is recommended to develop educational programs to raise societal awareness about the importance of psychological support and to inform health policies accordingly.
Uğur Ercan

Widespread neuronal hemokinin-1 expression in motor regions and its protective role in age-related impairment

2 weeks ago
Hemokinin-1 (HK-1) regulates several processes in the central and peripheral nervous systems, including musculoskeletal functions; however, its involvement in age-related motor coordination and muscle strength remains unknown. Therefore, these were investigated here with HK-1-deficient mice together with the expression patterns in the mouse and human motor coordination centers. Tac4 gene expression, encoding HK-1, was detected by RNAscope, and its age-dependent changes in the cerebellum and...
Dávid Vince Simon

Life-extending interventions do not necessarily result in compression of morbidity: a case example offering a robust statistical approach

2 weeks ago
Despite extensive research on life-extending interventions, rigorous statistical techniques to determine their impact on compression of morbidity (CoM) are rarely used. We present a case example of an analytical method for examining the effect of life-extending dietary interventions on CoM by comparing the rates of decline in vitality and survival toward the end of life. Using data from previous experimental studies in mice, we calculated the average rate of vitality decline by fitting...
Deependra K Thapa

An integrated multi-algorithm analysis to decipher senescence and metabolic characteristics in nucleus pulposus cells during disc degeneration

2 weeks ago
Accumulating evidence has suggested that intervertebral disc degeneration (IVDD) serves as a health problem deserving attention from worldwide, owing to the low back pain and even disability it causes. Cellular senescence, an irreversible process of terminal cell cycle arrest, plays an essential role in the degeneration of nucleus pulposus (NP) cells and IVDD with an unknown underlying mechanism. Here, we have explored the senescence signature in IVDD through high dimensional weighted gene...
Zhuangyao Liao

Single-cell transcriptomic analysis reveals immune remodeling in bone marrow during aged sepsis

2 weeks ago
Aging substantially increases susceptibility to sepsis, yet the underlying mechanisms of immune dysfunction in the elderly remain incompletely understood. Polymicrobial sepsis was induced in young and aged male mice via cecal ligation and puncture (CLP). Bone marrow from four groups (Y-Sham, n = 2; Y-CLP, n = 3; A-Sham, n = 2; A-CLP, n = 3) was analyzed by single-cell RNA sequencing and intercellular communication inferred via CellChat. Age-related immune changes were evaluated, and Transwell...
Yijia Lin