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The incidence of neurodegenerative diseases, including Alzheimer's disease (AD), continues to increase with the extension of human lifespan. However, their pathogenesis remains incompletely understood. Altered energy metabolism, particularly glucose metabolism involving glycolysis and oxidative phosphorylation, is widely recognized as an early pathological feature of neurodegenerative diseases. Astrocytes, the most numerous and widely distributed functional cells in the central nervous system...

Science, Ahead of Print.

Science, Ahead of Print.

Science, Ahead of Print.

Science, Ahead of Print.

A surprising discovery is reshaping scientists' understanding of how humans develop sharp central vision before birth. Instead of blue cone cells migrating away from the retina's center, the study found they transform into red and green cones under the influence of vitamin A-related signals and thyroid hormones. The findings could improve lab-grown retinal tissue and lay the groundwork for future cell therapies to restore vision lost to age-related eye diseases.

Poison control calls involving semaglutide (Ozempic and Wegovy) soared after the drug was approved for weight management, with researchers linking the increase to accidental dosing mistakes rather than intentional misuse. Simple education about proper weekly dosing and gradual dose increases could help prevent many of these avoidable incidents.

Scientists have created a silicon chip that can write dozens of DNA sequences simultaneously using electricity and water-based enzymes, offering a cleaner alternative to conventional DNA manufacturing. The breakthrough could eventually support portable DNA-writing devices and even massive DNA data storage, although new chemistry will be needed to scale the technology further.

Tiny silica nanoparticles engineered to seek out prostate cancer caused tumor cells to self-destruct and supercharged the immune system in preclinical mouse studies. Combined with immunotherapy, the treatment produced complete remissions in multiple mice, raising hopes for a powerful new approach to prostate cancer.

Scientists crack the secrets of Andean leaf-eared mice living near the top of the world

In a massive experiment, biologists are shooting thousands of aggressive barred owls—hoping to create a spotted owl “safe zone”

Researchers have cracked the code behind bacteria's ability to naturally manufacture multiple versions of powerful anti-cancer drugs. The discovery could make it much easier to engineer new cancer treatments inspired by nature, including improved versions of existing medicines.

Three approaches—including one that exploits Earth’s radiation belts—could help enforce ban on orbital nuclear weapons