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Prevalence of symptoms and their association to health-related quality of life among older men in Sweden - a cross-sectional study
CONCLUSION: Symptoms are highly prevalent among older men and significantly associated with lower HrQoL and pain, tiredness, depression, and anxiety were the most impactful. These findings underscore the importance of targeted symptom screening and management to promote healthy aging and well-being.
Viability of an educational program for lifestyle changes and an algorithm for the derivation of exercise programs in older people at risk of dependency at primary care: PRICA-POWFRAIL study protocol
BACKGROUND: This manuscript presents the study protocol of the PRICA-POWFRAIL randomized controlled trial. Frailty and pre-frailty are major predictors of functional decline and dependency in older adults, yet the implementation of personalized, scalable, and clinically interventions in primary care remains limited. This protocol describes the methodological design and planned evaluation of a lifestyle education programme and an individualized exercise-prescription algorithm aimed at improving...
Research on fall prediction in elderly patients with chronic diseases based on explainable machine learning: an aging perspective
No abstract
Effect of multicomponent exercise and nutrition intervention on frailty status in older adults: a network meta-analysis
CONCLUSION: The impacts of different interventions on frailty in older adults exhibited outcome-specific variations. Combined interventions were most effective in improving frailty scores, demonstrating potential synergistic effects between physical exercise and nutrition, while nutritional supplementation showed the most significant benefit for gait speed. Multicomponent exercise alone also produced significant improvements in frailty scores and physical performance. These findings suggest that...
Engineering chimeric antigen receptor CD4 T cells for Alzheimer's disease
Alzheimer's disease (AD) is the prevailing cause of age-associated dementia worldwide. Current standard of care relies on antibody-based immunotherapy. However, antibody-based approaches carry risks for patients, and their effects on cognition are marginal. Increasing evidence suggests that T cells contribute to AD onset and progression. Unlike the cytotoxic effects of CD8^(+) cells, CD4^(+) T cells capable of regulating inflammation show promise in reducing pathology and improving cognitive...
Engineering chimeric antigen receptor CD4 T cells for Alzheimer's disease
Alzheimer's disease (AD) is the prevailing cause of age-associated dementia worldwide. Current standard of care relies on antibody-based immunotherapy. However, antibody-based approaches carry risks for patients, and their effects on cognition are marginal. Increasing evidence suggests that T cells contribute to AD onset and progression. Unlike the cytotoxic effects of CD8^(+) cells, CD4^(+) T cells capable of regulating inflammation show promise in reducing pathology and improving cognitive...
Short-range electrostatic screening in ionic liquids as inferred by direct force measurements
Previous experimental reports of long-range interactions in ionic liquids (ILs) stand in contradiction with theoretical predictions and numerical simulations. To provide insights into the literature discrepancies regarding the experimental ranges of electrostatic screening, claimed with orders of magnitude larger, the interactions between pairs of mica and borosilicate surfaces confining ILs are investigated by two complementary advanced Surface Force Apparatuses. Regardless of differences in...
Aggregation-dependent epitope sequence and modification fingerprints of anti-Aβ antibodies
A hallmark of Alzheimer's disease (AD), the most common form of dementia, is the progressive accumulation of amyloid-beta (Aβ) peptides across distinct brain regions. Anti-Aβ antibodies (Aβ-Abs) targeting specific Aβ variants are essential tools for AD research, diagnostics, and therapy. The monoclonal antibodies Aducanumab, Lecanemab, and Donanemab have recently been approved as the first disease-modifying treatments for early AD, highlighting the clinical importance of their exact binding...
Editorial: Preserving emotional health in aging: unraveling the neural mechanisms and implications for neurodegenerative diseases
No abstract
Kidney function and all-cause mortality in the oldest-old population: a three-cohort longitudinal study
With increasing global life expectancy, the prognostic significance of kidney function in centenarians and supercentenarians should be clarified. The conventional estimated glomerular filtration rate (eGFR) threshold of < 60 mL/min/1.73 m² may not accurately reflect chronic kidney disease (CKD) in this population, highlighting the need for age-adapted definitions. This study investigated the association of kidney function with all-cause mortality across three age groups. Data from the Tokyo...
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