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A new analysis of the “Boltzmann brain” paradox suggests our memories and sense of reality could, in theory, be random illusions born from cosmic chaos. By uncovering circular reasoning in how physicists think about time and entropy, the study raises fresh doubts about what we can truly know about the past.

Nitric oxide (NO) is a pleiotropic gaseous mediator that regulates tissue homeostasis. At physiological levels, it functions as a precise signaling molecule through soluble guanylate cyclase (sGC) activation and the reversible S-nitrosylation of cysteine residues. However, in the context of aging and fibrosis, oxidative stress disrupts this balance. The increased generation of superoxide (O₂•⁻) anions diverts NO from homeostatic signaling to form peroxynitrite (ONOO⁻), a potent oxidant. This...

Aging, stress-related disorders, and chronic disease are often examined across separate domains-stress physiology, nutrition, psychiatry, and geroscience-despite converging on shared phenotypes of functional decline and reduced resilience. Although adaptive responses to stress are well characterized, why comparable exposures yield sustained resilience in some individuals but progressive dysfunction in others remains insufficiently explained. We propose that the missing unifying constraint is not...

This study examined associations between dietary habits and the risk of developing Cardiovascular Risk Factors, Aging, and Incidence of Dementia (CAIDE)-predicted late-life dementia risk in Korean adults. A total of 5,042 participants aged 40-69 years were included. We assessed associations between dietary patterns-the Mediterranean diet, Mediterranean-DASH Intervention for Neurodegenerative Delay (MIND) diet, Korean Healthy Eating Index (KHEI), and Empirical Dietary Inflammatory Index...

Vitamin K2 is a fat-soluble vitamin that has been reported to exhibit significant anti-stress activity. Anti-stress properties are considered to be closely associated with lifespan extension. Therefore, we investigated the effects of vitamin K2 on the lifespan and stress resistance of Caenorhabditis elegans, as well as the underlying mechanisms. In the present study, we found that the effects of Vitamin K2 on C. elegans are concentration-dependent. High concentrations (10 μM) of Vitamin K2 are...

Scientists have discovered a way to help the brain clean itself of harmful Alzheimer’s plaques by activating its own support cells. By increasing a protein called Sox9, researchers were able to boost the activity of astrocytes, star shaped cells that help maintain brain health. In mice that already showed memory problems, this approach reduced plaque buildup and preserved cognitive function over time.

Free-living amoebae are emerging as a global health concern, fueled by warming temperatures and outdated water systems. While many are harmless, some can cause deadly infections and even protect other dangerous microbes. Their ability to survive heat and disinfectants makes them especially hard to control. Scientists say improved surveillance and water treatment are urgently needed.

Life's Essential 8 (LE8) provides a multidimensional framework to assess cardiovascular health (CVH) in aging populations. The objective of this study was to describe LE8 component scores and their variation by age, sex, and psychosocial factors in middle-aged and older adults from Cádiz, Spain. Cross-sectional data were analyzed from 495 adults aged 50-79 years (59.4% women; 34.7% ≥ 65 years). LE8 scores were calculated following American Heart Association guidelines. Group comparisons used...

UVB-induced lens epithelial cell (LEC) senescence is among the important factors involved in the pathogenesis of age-related cataract (ARC). This study aimed to investigate the anti-aging effect of metformin (Met) and to elucidate the molecular mechanisms underlying this effect. RNA sequencing, nontargeted metabolomics analysis and network pharmacology were conducted. The expression of senescence indicators (P53 and P21^(Cip1)) and senescence-associated β-galactosidase (SA-β-gal) activity were...

CONCLUSIONS: A self-administered online geriatric screening tool adapted from the ICOPE framework is feasible, acceptable, and effective in detecting GSs in primary care. The high prevalence of GSs highlights the urgent need for scalable digital solutions. Integrating online screening into primary care workflows could facilitate early identification, optimize resource use, and promote healthy aging in resource-constrained settings.

CONCLUSIONS: Our findings suggest that the use of white noise can result in improving sleep quality and may be helpful in reducing fatigue in community-dwelling older adults and can be recommended as an low effort, low-cost and safe strategy to enhance sleep and reduce fatigue in older individuals.

Cancer-associated cachexia (CAC) is a multifactorial wasting syndrome characterized by progressive loss of fat and lean mass, systemic inflammation, and poor therapeutic responsiveness. While brown adipose tissue (BAT) is traditionally considered a protective, energy-dissipating organ, its qualitative remodeling in CAC remains poorly characterized.Here, we demonstrate that CAC induces a senescent conversion of BAT, marked by thermogenic failure, fibrosis, inflammation, and acquisition of a...

CONCLUSIONS: The use of an aging simulation suit was associated with improvements in specific dimensions of clinical empathy among healthcare professionals working in long-term care. This educational tool offers a valuable experiential approach that enhances understanding and compassion toward older adults. However, these findings are limited to short-term, self-reported measures, and no behavioral or patient outcome data were collected. Further longitudinal studies are needed to determine the...

Scientists have uncovered a surprising link between simple body movement and brain health: every time you tighten your abdominal muscles—even slightly—your brain may gently sway inside your skull. This subtle motion, triggered by pressure changes in connected blood vessels, appears to help circulate cerebrospinal fluid around the brain, potentially flushing out harmful waste.

Building muscle doesn’t have to mean exhausting workouts or soreness. Researchers found that slow, controlled “lowering” movements can boost strength more efficiently while requiring less effort. Even five minutes a day of simple exercises like chair squats or wall push-ups can make a real difference. It’s a smarter, easier way to get stronger—no gym required.

Shirley Meng explains why her passion for decarbonizing the global economy required her to relocate

Sensor array traces how rocks conduct electricity, exposing ancient continental fragments, mineral targets, and grid hazards

Gut microbiota dysbiosis is a driving factor in Alzheimer's disease (AD), yet the mechanisms behind remain elusive. Emerging evidence highlights that outer membrane vesicles (OMVs) are critical mediators of microbiota-host communication. Here, we observed a reduction in a gut probiotic Escherichia coli Nissle 1917 (EcN)-like strain in AD patients, and its levels are positively associated with cognitive ability. The EcN OMVs containing outer membrane protein A (OmpA) translocate to the brain,...

Synaptic function and plasticity depend on the precise control of protein abundance and turnover, governed by the balance of synthesis and degradation. This review examines the regulatory mechanisms that maintain synaptic protein stability, focusing on the ubiquitin-proteasome system, autophagy-lysosomal pathways, and related proteolytic systems. We detail how key enzymes, including E3 ligases such as Nedd4-1, Mdm2, and Parkin, and deubiquitinating enzymes like USP46 and USP8, dynamically...

Physical resilience is a term used to describe an individual's response to physical and physiological stressors across the fields of gerontology and rehabilitation sciences. However, the term has not yet undergone a rigorous examination of its underlying assumptions, which has hindered its theoretical development and empirical measurement. This paper reviews the existing definitions of physical resilience in the context of human physical and psychological systems to examine its underlying,...