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The controversial interplay between hyperinflammation and immunosenescence in elderly critically ill co-infected patients
CONCLUSION: This study reveals immune dysregulation characterized by hyperinflammation-immunosenescence coexistence; a preliminary prediction model (TP, NLR, age, viral coinfection) requires prospective multicenter validation.
Contributory and developmental social participation and depressive symptoms among older adults in China: urban-rural and gender disparities
BACKGROUND: Existing research on social participation and later-life mental health often relies on fragmented classifications, pays insufficient attention to family-oriented contributory activities, and gives limited consideration to subgroup heterogeneity. To address these gaps, this study develops a contributory-developmental framework of social participation and examines the differential associations between various types of social participation and depressive symptoms among Chinese older...
Aging restricts maturation of CXCL13(+) T follicular helper cells in human immunity
A decline in specific antibody responses is a hallmark of human aging, yet the differential contributions of B and T lymphocytes remain unclear. CXCL13 is a chemokine that shapes germinal center (GC) organization, but the regulation of human-specific CXCL13^(+) T follicular helper (Tfh) cells during aging is not known. Using human tonsil organoids, single-cell RNA sequencing, and CRISPR perturbations, we mapped age-associated changes in Tfh cells, the cell type that provides help to B cells in...
Socially shared emotions shape the activity of the medial prefrontal cortex during inference of others' emotional states
The medial prefrontal cortex (mPFC) weighs options during decision-making, but its role in inferring competing emotional states and how this process changes with age, remain unclear. We recorded brain activity with functional MRI while 20 young and 40 older adults inferred the emotions of actors shown in ecological yet controlled social interactions. Socially shared representations about the timing, accuracy, and uncertainty of emotional inferences were defined using response distributions from...
Correction to 'Full-length direct RNA sequencing reveals extensive remodeling of RNA expression, processing and modification in aging Caenorhabditis elegans'
No abstract
Genome integrity, somatic mutation, and the N-of-1 imperative in aging research
Aging research has made remarkable progress in describing aging through the genetic architecture of longevity, epigenetic clocks, proteomic signatures, and systems-level analyses. Yet a critical dimension remains underrepresented: the role of genome integrity, germline and somatic mutation accumulation in individual-specific vulnerability, frailty, and multimorbidity across the life course. The need for individual-level thinking has deep roots, from Darwin's emphasis on individual variation in...
Reticulophagy limits Alzheimer's disease pathology through FAM134B-dependent APP clearance
Selective autophagy maintains organelle and proteome homeostasis through receptor-mediated degradation of damaged membranes and aggregation-prone proteins. Although autophagy dysfunction and endoplasmic reticulum (ER) abnormalities are prominent features of Alzheimer's disease (AD), whether reticulophagy directly contributes to amyloid precursor protein (APP) turnover has remained unclear. We identify FAM134B/RETREG1 as a specific receptor that recognizes ER-localized APP and promotes its...
Barriers and facilitators to physical activity among older Chinese adults in the UK: a qualitative descriptive study
CONCLUSIONS: Older Chinese adults in the UK exhibit diverse PA patterns and face a range of barriers, underscoring the need to consider their varied needs and experiences when designing interventions. Factors influencing PA engagement align with the COM-B framework, highlighting the importance of addressing capability, opportunity, and motivation. These findings provide a practical evidence base to inform behaviour change interventions, supporting the development of culturally tailored...
Physical activity patterns from mid- to late adulthood and risk of sarcopenia in older adults: the HUNT study
CONCLUSION: Long-term PA shows a clear dose-response relationship with sarcopenia risk in later life. While sustained activity across adulthood confers the greatest benefit, initiating PA even later in life remains associated with lower odds of sarcopenia.
Vascular Immune Remodeling: A CD4<sup>+</sup> T Cell-Driven Immune Trajectory Associated With Arterial Stiffness
Arterial stiffness is a hallmark of vascular aging and a major risk factor for cardiovascular disease. While immune aging-typically characterized by reduced T cell receptor (TCR) diversity and CD8^(+) memory expansion-contributes to this process, growing evidence suggests that peripheral immune dysregulation may impair vascular function through mechanisms distinct from classical immunosenescence. To investigate this, we profiled peripheral TCRβ repertoires from 563 adults without clinically...
Scientists discover the master clock that controls biological growth and development
A newly discovered genetic clock acts as the master timekeeper for development, orchestrating crucial bursts of gene activity throughout a worm’s growth. When the clock is disrupted, development stops, offering fresh clues about how growth-related disorders may arise.
Daily briefing: Lung microbiome linked to a mysterious tissue-scarring condition
Science with military applications is cited more than civilian-only research
Babies’ birth weight improves with help of payments to parents
Author Correction: Physiology and immunology of a pig-to-human decedent kidney xenotransplant
Device could sniff out fusion reactors secretly making material for a nuclear bomb
What’s behind China’s historically high counts of corresponding authors?
This mysterious lung disease affects millions of people — but a drug tested in mice shows promise
Long-range extended chains arising from polymerization-driven spontaneous assembly
Science, Ahead of Print.
Cancer’s favorite escape trick may actually make it easier to kill
Scientists have uncovered a surprising new way the immune system fights cancer, overturning a core belief that has guided immunology for decades. The research found that when cancer cells shut down a key immune-recognition molecule called MHC I—a common trick used to hide from “killer” T cells—they can actually become more vulnerable to attack by a different group of immune cells known as CD4+ “helper” T cells.