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Talk therapy
Science, Volume 392, Issue 6795, Page 330-330, April 2026.
Mesothermic fishes face high fuel demands and overheating risk in warming oceans
Science, Volume 392, Issue 6795, Page 301-305, April 2026.
Super-nano domains enable strength-conductivity synergy in copper foils
Science, Volume 392, Issue 6795, Page 275-279, April 2026.
Structural basis for DNA processing and membrane translocation by ComEC in natural transformation
Science, Volume 392, Issue 6795, Page 311-316, April 2026.
Guidance of cellular nematic elastomers into shape-programmable living surfaces
Science, Volume 392, Issue 6795, Page 317-323, April 2026.
Late Miocene Colorado River arrival in the Bidahochi basin supports spillover origin of Grand Canyon
Science, Volume 392, Issue 6795, Page 289-295, April 2026.
Calcium-triggered apoplastic ROS bursts balance gravity and mechanical signals for soil navigation
Science, Volume 392, Issue 6795, Page 296-300, April 2026.
Determination of the Solar System contribution to the soft x-ray sky
Science, Volume 392, Issue 6795, Page 285-288, April 2026.
Our cosmos, ourselves
Science, Volume 392, Issue 6795, Page 261-261, April 2026.
The life and legacy of George Schaller
Science, Volume 392, Issue 6795, Page 262-262, April 2026.
Reimagining human-centric drug development with new approach methodologies
Science, Volume 392, Issue 6796, Page 371-378, April 2026.
Grand canyon’s origin resolved? Ancient lake's flood may have etched famed gorge
Mineral grains show Colorado River filled a basin at the canyon’s head millions of years ago
Scientists stunned by ‘fundamentally new way’ life produces DNA
Newly discovered bacterial defense system challenges genetic code’s central dogma
First complete genome loaded onto a quantum computer
Researchers encode the tiny hepatitis D virus in an early step toward “quantum genomics”
Ten thousand years ago, human evolution went into overdrive
Ancient DNA reveals “massive” genetic shifts tied to rise of farming, wheels, and metal tools
Electromagnetic field-inducible in vivo gene switch for remote spatiotemporal control of gene expression
Gaining precise control of gene expression is crucial in biomedical applications. However, spatiotemporal precision remains challenging. Here, we present a remotely controlled in vivo gene switch responsive to electromagnetic fields (EMFs) that enables precise spatiotemporal activation of target genes. We uncovered the EMF-inducible gene switch activation mechanism via a CRISPR-Cas9 screen, identifying cytochrome b5 type B (Cyb5b) as an essential mediator likely acting as an EMF sensor. The...
Single-nucleus brain transcriptomics reveals microglia dysfunction in multiple system atrophy
Multiple system atrophy (MSA) is a rare, age-related neurodegenerative disease that shares clinical and pathological features with Parkinson's disease (PD) but presents a more devastating disease course. To elucidate the distinct cellular pathophysiology, we performed single-nucleus RNA sequencing on postmortem striatal brain tissue from 7 MSA and 12 PD patients, and 10 non-neurological cases. Here, we show significant compositional differences in astroglia and microglia subtypes, while...
Variants in the proteasome regulator PSMF1 cause a phenotypic spectrum from parkinsonism to perinatal lethality
Dissecting biological pathways highlighted by Mendelian gene discovery has provided critical insights into the pathogenesis of Parkinson's disease (PD) and neurodegeneration. This approach ultimately catalyzes the identification of potential biomarkers and therapeutic targets. Here we identify PSMF1 as a gene implicated in parkinsonism and childhood neurodegeneration. We find that biallelic PSMF1 missense and loss-of-function variants co-segregate with phenotypes from early-onset PD to perinatal...
Human immune aging clock identifies RUNX1 as a decelerator of T cell senescence
Immunosenescence drives organismal aging, yet quantifying its heterogeneity to uncover therapeutic targets remains challenging. We construct a human immune aging clock from single-cell multi-omics data of nearly 1.2 million human peripheral blood mononuclear cells from 230 individuals, precisely mapping immune aging. T cell (TC) transcriptomes are key predictors, revealing hallmarks such as naive cell loss and clonal contraction. This framework identifies the transcription factor RUNX1, whose...
Cellular memory of sub-lethal stress
Regulated cell death-processes such as apoptosis, pyroptosis, necroptosis, and ferroptosis-is essential for development, tissue homeostasis, and response to infection or cellular stress. The proteins involved in regulated cell death necessarily possess powerful and potentially damaging activities, including proteolysis, membrane pore formation, DNA cleavage, and inflammatory pathway activation. Traditionally, these activities drive cell death. However, sub-lethal activation of these pathways...