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Science, Volume 392, Issue 6793, Page 102-109, April 2026.

Science, Volume 392, Issue 6793, Page 63-68, April 2026.

Science, Volume 392, Issue 6793, Page 69-76, April 2026.

Science, Volume 392, Issue 6793, Page 34-34, April 2026.

Science, Volume 392, Issue 6793, Page 33-33, April 2026.

Science, Volume 392, Issue 6794, Page 156-156, April 2026.

Repeated supernovae flashes, warped by gravity, could resolve a cosmological dispute

Flexible rhythm perception, once thought to require a big brain, has been shown in humble bumble bees

Analysis of gravitational waves supports theory that some stars explode without leaving behind black holes

Bristling, multilegged ocean swimmer shows early emergence of claws  

Ambitious effort tested whether more than 100 papers held up on multiple types of “repeatability” tests

Gastrointestinal dysfunction often precedes motor symptoms in Parkinson's disease (PD), suggesting the enteric nervous system (ENS) is central to early pathogenesis. How α-synuclein contributes to ENS dysfunction, and how inflammation modulates this, remains unclear. Here we show that Tumor Necrosis Factor alpha enhances α-synuclein accumulation in induced pluripotent stem cell-derived enteric neurons and glia, and impairs the malate-aspartate shuttle, a key pathway for mitochondrial energy...

Cancer immunotherapy has markedly improved patient outcomes, particularly when combined with conventional treatments such as chemotherapy, radiotherapy, and targeted therapy. Following these therapies, however, a subset of cancer cells can enter a senescent state, ceasing proliferation while remaining metabolically active and persistent within tissues. Such therapy-induced senescent cancer cells (TISCCs) significantly influence antitumor immune responses. TISCCs can enhance tumor immunogenicity...

No abstract

Neurons assemble into breathtakingly intricate circuits that govern behavior and often perdure for life. How injured or aged neurons control their complex morphological connections to survive or perish remains an exciting and open question. Using the genetics of Caenorhabditis elegans, Park et al. uncover that lipid biosynthesis is critical for both neuronal regrowth after injury, and for maintaining neuronal morphology during aging. This primer is designed to help students read and understand...

Lipidomic analysis enables the detailed characterization of platelet concentrates from donors of different ages, offering valuable insights into the role of lipid mediators in aging and transfusion-related adverse reactions (AR). In this study, we analyzed lipidomic profiles from a cohort of single-donor apheresis platelet concentrates, classified into three age groups: 20-44, 45-59, and 60-70 years. Total levels of LPC, LPA, S1P, and eicosanoids did not exhibit significant age-related changes....

Nanoscale chromatin domains have emerged as fundamental units of mammalian genome organization during interphase and mitosis. Single-molecule localization microscopy now enables their direct visualization, revealing conserved features including characteristic packing, enrichment of linker histones, and radial stratification of histone marks. These domains act as dynamic regulators of gene activity, remodel in response to developmental and environmental cues, and become disrupted in disease....

Aging impairs vision, but its specific impact on the neural channels underlying pattern processing is unknown. By examining individual differences in behavioral data from 52 younger and 50 older adults, we investigated how aging reorganizes underlying channels for detecting first-order (defined by luminance static or in motion) and second-order (defined by contrast, motion, or orientation) patterns. We identified a key organizational feature in youth on spatial processing: a global factor...

Neurodegeneration shows regional and cell-type-specific patterns in ageing and disease¹, but the underlying mechanisms for cell-type-specific neuronal losses remain poorly understood. Previous studies have shown that upper cortical layer thinning occurs in progressive human multiple sclerosis (MS) and that cortical layer 2 and layer 3 (L2/3) excitatory neurons (L2/3ENs) that express CUT-like homeobox 2 (CUX2) are selectively vulnerable to degeneration². Here we report that L2/3ENs within MS...

The MetaboHealth score, a metabolomics-based biomarker trained on mortality, is associated with ageing-related phenotypes and morbidity, but its heritable component is still uncertain. Understanding genetic versus environmental contributions is essential for its utility as an intervention-responsive biomarker. Hence, the aim of this study was to estimate heritability of the MetaboHealth score in the large Swedish TwinGene cohort and evaluate interactions with modifiable lifestyle factors and...