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CONCLUSIONS: IC captures dimensions of functional vulnerability not fully accounted for by comorbidity burden alone.

No abstract

Interindividual variability in response to cognitive training remains a key barrier to developing precision approaches for maintaining neurocognitive health across the lifespan. Characterizing changes in system-level cognitive reorganization may provide insight into mechanisms of cognitive reserve, resilience, and plasticity that shape divergent aging trajectories and vulnerability to age-related cognitive decline. This exploratory study applies a cognitive network framework to examine how...

CONCLUSION: Physical activity interventions are associated with reductions in frailty when assessed using the Fried phenotype. However, substantial heterogeneity in frailty assessment and intervention reporting limits comparability and clinical translation. Standardization of frailty measures and improved reporting of intervention characteristics are needed to optimize and implement effective PA strategies in older adults.

CONCLUSION: Geriatric depression in Türkiye is a multidimensional phenomenon with complex socioeconomic and environmental determinants, in addition to biological factors. In particular, older women, individuals living alone, and economically disadvantaged groups are at high risk. The findings indicate that, to support healthy aging, clinical interventions alone are insufficient; strengthening social support networks, enhancing urban accessibility, and urgently developing inclusive public health...

Aging, as an intrinsic risk factor, accelerates gingival inflammation and periodontal diseases. However, the cellular and molecular mechanisms underlying gingival aging remain unclear, hindering the development of targeted therapies. In this study, we performed the first single-cell transcriptomic analysis of aging human gingiva, identifying primary cilia as potential regulators of gingival fibroblast senescence. We demonstrated that aged gingival tissues exhibit increased fibroblast senescence...

The aggregation of alpha-synuclein (aSyn) into intraneuronal inclusions of heterogeneous morphology, known as Lewy bodies (LBs), is a defining hallmark of Parkinson's disease (PD); yet, our understanding of the mechanisms underpinning their formation and heterogeneity remains incomplete. Here, we present a human isogenic induced pluripotent stem cell-derived dopaminergic neuron (iDA) model that faithfully recapitulates the diverse biochemical, morphological, and ultrastructural features of LB...

Mitochondria and inflammation are tightly linked in aging and Alzheimer's disease (AD), and recent evidence implicates mitochondrial double-stranded RNA (mt-dsRNA) as a potential trigger of inflammation. We examined mt-dsRNA accumulation and dsRNA signaling in brain aging and AD using complementary human brain tissue and in vitro transcriptomic datasets by quantifying mitochondrial transcripts, dsRNA editing, and related gene expression patterns. We found that mt-dsRNA signatures increased after...

CONCLUSION: The results of this study showed that holding group poetry reading sessions can promote meaning in life, especially in the domain of "searching for meaning" among the elderly. But results showed no significant difference between the two groups' Subjective Vitality mean scores after the intervention. Therefore, holding such classes in elderly day care centers or nursing homes are recommended to improve meaningful life in the elderly.

CONCLUSIONS: Adherence in later life reflects how older adults position themselves toward self‑care in the face of vulnerability, changing identities, and real‑world constraints. Clinical practice may benefit from linking recommendations to what matters most to patients, simplifying regimens, strengthening relational support, and addressing structural barriers. Tailoring care to patients' life contexts may foster more sustainable and meaningful engagement with treatment.

CONCLUSIONS: Immune-inflammatory and nutritional status mediate age-dependent survival disparities in older NPC patients. These findings underscore the clinical imperative of addressing inflammatory burden and nutritional depletion in geriatric oncology and advocate for integrated biomarker-guided management strategies.

Mitochondria and inflammation are tightly linked in aging and Alzheimer's disease (AD), and recent evidence implicates mitochondrial double-stranded RNA (mt-dsRNA) as a potential trigger of inflammation. We examined mt-dsRNA accumulation and dsRNA signaling in brain aging and AD using complementary human brain tissue and in vitro transcriptomic datasets by quantifying mitochondrial transcripts, dsRNA editing, and related gene expression patterns. We found that mt-dsRNA signatures increased after...

INTRODUCTION: Precise regulation of grip forces is fundamental for skilled object manipulation and independent navigation of everyday activities throughout the lifespan. Maximal grip strength is a widely used biomarker of aging and frailty, but it provides limited insight into the temporal and inhibitory control mechanisms required for dexterous prehension. Evidence suggests that grip-force release, which requires integration of sensory feedback and inhibition of sustained grip, may be...