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Party pooper: grandparents’ COVID risk rose after grandchildren’s birthdays
Daily briefing: The rise of evidence-based medicine
First ‘true sugar’ molecule found in space — offering hints to life’s origins
Author Correction: OR7A10 GPCR engineering boosts CAR-NK therapy against solid tumours
Perovskite–organic tandem solar cells with a photo-transformable stabilizer
Spatial mapping and senolytic targeting of senescent and disease-associated microglia in aged mouse brain white matter
Mapping and manipulating aged and senescent microglia
This microbiologist endured a four-year court battle over COVID-19 tests
Epigenetic editing makes its mark
The rise of evidence-based medicine and the ‘mavericks’ who championed it
How voluntary work can boost your career in science
Rights for rivers and ice cream for all: top reads for the summer holidays
Tall and small trees are equally vulnerable to drought
Scientists discover a hidden heart valve risk linked to gum disease
Researchers found that bacteria linked to gum disease may help drive the development of calcific aortic valve stenosis by triggering inflammation and calcium buildup in the heart valve. The early findings suggest that keeping gums healthy could play a role in reducing the risk of this serious heart condition.
Plan to turn major monkey research facility into sanctuary may be dead
Lack of federal funds may have forced Oregon university to drop idea of converting national primate center into science-free refuge
Where you live could shape your dementia risk, massive study finds
Researchers analyzing data from more than 214,000 people found that dementia risk factors differ widely across countries, challenging the idea of a one-size-fits-all prevention strategy. At the same time, they uncovered surprisingly consistent patterns that could help shape smarter, more targeted public health efforts.
As the Arctic warms, gray whale boom turns into a bust
Scientists point to changes that jeopardize the marine mammals’ critical feeding grounds
Alzheimer's tau protein has a surprising secret role in memory
Researchers found that tau is essential for turning new experiences into lasting memories by helping organize the brain's memory-storing cells. The mouse study also revealed how abnormal tau may contribute to Alzheimer's by disrupting both the formation of new memories and the recall of existing ones.
This ultrasound treatment may help stop arthritis before it starts
A simple, non-invasive ultrasound treatment could one day help injured joints heal instead of remaining trapped in a cycle of damaging inflammation. Researchers at The University of Alabama in Huntsville found that continuous low-intensity ultrasound encouraged key immune cells called macrophages to shift from an inflammatory state toward one that supports tissue repair.
From Gut to Fat: Intestinal Epithelial Exosomes Target PDGFRalpha(+) Progenitors to Promote Lipogenesis and Counteract Subcutaneous Adipose Tissue Atrophy in Aging
Age-related subcutaneous adipose tissue (SAT) atrophy is a hallmark of aging, contributing to metabolic dysfunction and systemic aging. The mechanisms underlying SAT atrophy and potential therapeutic strategies remain poorly understood. Here, we report that small intestinal epithelium-derived exosomes (SI-Exos) mediate gut-adipose communication and play a pivotal role in age-related SAT remodeling. We found that the miRNA cargo of SI-Exos undergoes significant age-related changes. Administration...