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Lysosomal dysfunction is a hallmark of cellular senescence, yet the mechanisms governing lysosomal protein trafficking remain incompletely understood. Here, we show that CD-M6PR, a principal receptor for lysosomal enzyme transport, is markedly reduced in senescent fibroblasts and in aged mice and humans, and that its loss correlates with the severity of autolysosomal impairment. Mechanistically, the reduction of CD-M6PR in senescent cells mainly stems from the accelerated proteasome-mediated...

CONCLUSION: The needs of older adults and community workers in utilizing technology for health exhibit a multi-layered interaction. Older adults require simplified technologies and social support, and community workers demand technical training and policy backing. The study's findings support a reframing of immediate recommendations towards age-friendly design, structured training for community workers, and policy support for resources. Developing artificial intelligence-assisted tools is a...

CONCLUSION: The findings reinforce the multidimensional nature of dementia and the importance of accessible factors for supporting screening/triage and prioritization in primary care. Strengthening public policies focused on promoting brain health can contribute significantly to the efficient allocation of resources in primary care and dementia prevention in Brazil.

A new breakthrough could change how high cholesterol is treated, offering a powerful alternative to traditional drugs. Researchers have developed tiny DNA-based molecules that shut down PCSK9—a key protein that keeps “bad” LDL cholesterol circulating in the blood. By blocking this protein, cells can absorb more cholesterol instead of letting it build up in arteries, dramatically lowering levels linked to heart disease.

Kidney stones are notoriously painful—and frustratingly common, with many people facing repeat episodes. A massive new study tested whether a high-tech hydration program—complete with smart water bottles, reminders, coaching, and even financial incentives—could help people drink enough water to stop stones from coming back.

Chronic stress is already tough on your gut—but new research suggests late-night eating could make things even worse. Scientists analyzing thousands of people found that those under high stress who also ate a large portion of their calories after 9 p.m. were far more likely to suffer from constipation and diarrhea. The combination appears to hit the gut twice, not only disrupting digestion but also reducing the diversity of beneficial gut bacteria.

Scientists have uncovered a surprising new layer of complexity in Cannabis, identifying dozens of previously unknown compounds—including the first-ever evidence of rare molecules called flavoalkaloids in its leaves. These compounds, prized for their potential health benefits, were hidden among a rich mix of plant chemicals that vary dramatically even between just a few strains.

A key protein involved in fat metabolism has been found to do more than scientists once thought. Instead of just releasing fat, it helps maintain healthy fat tissue and balance in the body. When it’s missing or disrupted, the results can be surprisingly harmful. This finding reshapes how researchers think about obesity and metabolic disease.

Galaxy clusters obey the inverse square law across hundreds of millions of light-years

Neurons and glia are distinct in their morphology, development and function, possessing unique transcriptomes and proteomes, but little is known about their metabolomes. The challenge of brain cell metabolic profiling is to obtain a large number of cells for reliable analysis. Here we purified microglia, astrocytes and neurons from mouse brains, identifying >70 metabolites through targeted metabolomics and 9,854 metabolite features via untargeted metabolomics. We systematically characterized...