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A helper NLR channels organellar calcium to trigger plant immunity

1 week 6 days ago
Science, Volume 392, Issue 6797, Page 499-505, April 2026.
Tarhan Ibrahim, Freddie J. King, AmirAli Toghani, Luyao Wang, Saskia Jenkins, Enoch Lok Him Yuen, Hung-Yu Wang, Cristina Vuolo, Nick Eilmann, Vanda Adamkova, Khong-Sam Chia, Baptiste Castel, Jonathan D. G. Jones, Philip Carella, Chih-Hang Wu, Jiorgos…

Performance of a large language model on the reasoning tasks of a physician

1 week 6 days ago
Science, Volume 392, Issue 6797, Page 524-527, April 2026.
Peter G. Brodeur, Thomas A. Buckley, Zahir Kanjee, Ethan Goh, Evelyn Bin Ling, Priyank Jain, Stephanie Cabral, Raja-Elie Abdulnour, Adrian D. Haimovich, Jason A. Freed, Andrew Olson, Daniel J. Morgan, Jason Hom, Robert Gallo, Liam G. McCoy, Haadi Mombini…

A hidden map in your nose could explain how smell works

1 week 6 days ago
Scientists have finally cracked one of the biggest mysteries in the senses: how smell is organized. By mapping millions of neurons in mice, researchers discovered that smell receptors in the nose aren’t random at all—they’re arranged in neat, overlapping stripes based on receptor type, forming a hidden structure scientists never knew existed. Even more striking, this layout mirrors how smell information is mapped in the brain, revealing a coordinated system from nose to neural circuits.

First-ever 3D view shows how killer T cells destroy cancer

1 week 6 days ago
The body’s “killer” T cells don’t just attack—they strike with astonishing precision, forming a tiny, highly organized contact zone that lets them destroy dangerous cells without harming their neighbors. Now, scientists have captured this process in unprecedented detail, revealing a hidden world of molecular choreography.

The role of ultrasound in addressing neurodegenerative diseases: A review of mechanisms, applications, and challenges

2 weeks ago
With the aging of the global population, neurodegenerative diseases have become a major public health challenge. Currently, there are many limitations in the traditional treatment of neurodegenerative diseases, such as medicine, deep brain stimulation, transcranial magnetic stimulation, and transcranial direct current stimulation, including the inability to penetrate the blood-brain barrier (BBB) accurately and challenges in achieving precise and quantitative control during the treatment...
Yanqiu Zhu

Serious side effects of Alzheimer's immunotherapy demand scrutiny

2 weeks ago
Monoclonal antibodies targeting amyloid-β, i.e., lecanemab and donanemab, have recently been approved for treating early Alzheimer's disease (AD). Though these antibodies are by many considered milestones in AD therapy, clinical approvals have been inconsistent due to ongoing debates over their clinical benefit and safety. The reported cognitive decline slowing is modest and often below the thresholds for clinically significant differences on outcome scales. Moreover, these therapies are linked...
Poul F Høilund-Carlsen