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Grassroots efforts explore what works—and where the tensions lie

Benefactors agree to help support next-generation particle accelerator, but billions more are needed

Rand Paul has blasted government science officials and scientists over COVID-19’s origin

Eindhoven University of Technology’s success sets example for other institutions to follow, researchers say

Scientists question the value of the proposed study, which will investigate a vaccine long known to be efficacious and safe

Genetic variants associated with complex traits often lie in distal enhancers. While candidate enhancers have been mapped genome wide, their functional state and gene targets in specific cell types remain unclear. Here we present AstroREG, a resource of enhancer-gene interactions in human primary astrocytes, generated by combining CRISPR inhibition (CRISPRi), single-cell RNA-seq and machine learning. By functionally testing nearly 1,000 PsychENCODE enhancers, we identified more than 150...

CONCLUSION: Postmenopausal women showed distinct epigenetic patterns in response to exercise, although these differences must be interpreted cautiously given the small premenopausal sample size. These results suggest potential immune cell-associated DNA methylation markers to inform personalized exercise strategies supporting healthy aging in women.

For memories to remain relevant and adaptive over the lifespan, modifications under specific conditions are required. Memory reconsolidation theory suggests that when a memory is reactivated, it can become labile, a state known as destabilization. This process is regulated by complex and dynamic neurobiological changes representing biological boundary conditions, which likely protect important memories from undergoing unnecessary or potentially maladaptive modifications. External cues, such as...

Diapause is an evolutionarily conserved strategy that enables many organisms to survive prolonged exposure to harsh environmental stressors. During this state, organisms drastically reduce their metabolic rate, halt development, and enhance stress tolerance in an energy-efficient manner. Remarkably, many diapausing organisms appear to substantially slow or suspend aging as a result of profound metabolic depression and developmental arrest. Consequently, diapause and aging appear to be programmed...

Sepsis-induced cardiac dysfunction is a major contributor to sepsis-related mortality, and many patients continue to experience long-term cardiac complications after recovery. Here, we demonstrate that cardiac senescence is a key feature of sepsis-associated cardiac dysfunction, with endothelial cells identified as the predominant senescent population in septic cardiac tissue. However, the pathogenic drivers of endothelial senescence in sepsis remain poorly characterized. Among potential...

Adult stem cells (SCs) transition between quiescent and active states to maintain tissue integrity, and dysregulation of this balance can lead to tissue degeneration, cancer, or premature aging. Both intrinsic factors and extrinsic niche signals influence these states; however, the molecular mechanisms that integrate extrinsic cues with intrinsic programs remain poorly understood. Here, we show that the conserved repressive histone mark, H2AK119ub, serves as a molecular switch linking inhibitory...