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Advanced CMOS manufacturing of superconducting qubits on 300 mm wafers
Rise of ChatGPT and other tools raises major questions for research
Colossal 'jets' shooting from a black hole defy physicists' theories
AI’s international research networks mapped
A lymphocyte chemoaffinity axis for lung, non-intestinal mucosae and CNS
A broader view of the diversity of human gene expression
Science-policy advisers shape programmes that solve real-world problems
A brain circuit that cements the memory of socially learnt food preferences
The UK’s $1-billion bet to create technologies that change the world
This ‘scuba diving’ lizard has a self-made air supply
‘Worst nightmare’: Elon Musk’s Starlink satellites could blind radio telescopes
Second generation satellites emit 30 times more stray radio waves than before
Yes, cats are liquids—but only in one dimension
Pet felines seem much less aware of their bodies when it comes to vertical squeezes
Identification of AS1842856 as a novel small-molecule GSK3α/β inhibitor against Tauopathy by accelerating GSK3α/β exocytosis
Glycogen synthase kinase-3α/β (GSK3α/β) is a critical kinase for Tau hyperphosphorylation which contributes to neurodegeneration. Despite the termination of clinical trials for GSK3α/β inhibitors in Alzheimer's disease (AD) treatment, there is a pressing need for novel therapeutic strategies targeting GSK3α/β. Here, we identified the compound AS1842856 (AS), a specific forkhead box protein O1 (FOXO1) inhibitor, reduced intracellular GSK3α/β content in a FOXO1-independent manner. Specifically, AS...
Glial <em>swip-10</em> controls systemic mitochondrial function, oxidative stress, and neuronal viability via copper ion homeostasis
Cuprous copper [Cu(I)] is an essential cofactor for enzymes that support many fundamental cellular functions including mitochondrial respiration and suppression of oxidative stress. Neurons are particularly reliant on mitochondrial production of ATP, with many neurodegenerative diseases, including Parkinson's disease, associated with diminished mitochondrial function. The gene MBLAC1 encodes a ribonuclease that targets pre-mRNA of replication-dependent histones, proteins recently found in yeast...
The primary cilium of cholinergic neurons may be a linchpin in the progression of Parkinson's Disease
No abstract
Correction to Supporting Information for Woerman et al., Familial Parkinson's point mutation abolishes multiple system atrophy prion replication
No abstract
Structural basis of CDNF interaction with the UPR regulator GRP78
Cerebral dopamine neurotrophic factor (CDNF) is an unconventional neurotrophic factor that is a disease-modifying drug candidate for Parkinson's disease. CDNF has pleiotropic protective effects on stressed cells, but its mechanism of action remains incompletely understood. Here, we use state-of-the-art advanced structural techniques to resolve the structural basis of CDNF interaction with GRP78, the master regulator of the unfolded protein response (UPR) pathway. Subsequent binding studies...
Hippo effector, Yorkie, is a tumor suppressor in select <em>Drosophila</em> squamous epithelia
Mammalian Yes-associated protein (YAP) and transcriptional coactivator with PDZ-binding motif (TAZ) and Drosophila Yorkie (Yki) are transcription cofactors of the highly conserved Hippo signaling pathway. It has been long assumed that the YAP/TAZ/Yki signaling drives cell proliferation during organ growth. However, its instructive role in regulating developmentally programmed organ growth, if any, remains elusive. Out-of-context gain of YAP/TAZ/Yki signaling often turns oncogenic. Paradoxically,...
The role of signaling pathways mediated by the GPCRs CysLTR1/2 in melanocyte proliferation and senescence
In contrast with sun exposure-induced melanoma, rarer melanocytic tumors and neoplasms with low mutational burden present opportunities to study isolated signaling mechanisms. These include uveal melanoma and blue nevi, which are often driven by mutations within the G protein-coupled signaling cascade downstream of cysteinyl leukotriene receptor 2. Here, we review how the same mutations within this pathway drive the growth of melanocytes in one tissue but can inhibit the growth of those in...
Iron chelation as a new therapeutic approach to prevent senescence and liver fibrosis progression
Iron overload and cellular senescence have been implicated in liver fibrosis, but their possible mechanistic connection has not been explored. To address this, we have delved into the role of iron and senescence in an experimental model of chronic liver injury, analyzing whether an iron chelator would prevent liver fibrosis by decreasing hepatocyte senescence. The model of carbon tetrachloride (CCl(4)) in mice was used as an experimental model of liver fibrosis. Results demonstrated that during...