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Quantifiable blood TCR repertoire components associate with immune aging
T cell senescence alters the homeostasis of distinct T cell populations and results in decayed adaptive immune protection in older individuals, but a link between aging and dynamic T cell clone changes has not been made. Here, using a newly developed computational framework, Repertoire Functional Units (RFU), we investigate over 6500 publicly available TCR repertoire sequencing samples from multiple human cohorts and identify age-associated RFUs consistently across different cohorts....
Daily briefing: Common diabetes drug slows monkey brain-ageing
No abstract
CASIN exerts anti-aging effects through RPL4 on the skin of naturally aging mice
Skin aging has been associated with the onset of various skin issues, and recent studies have identified an increase in Cdc42 activity in naturally aging mice. While previous literature has suggested that CASIN, a specific inhibitor of Cdc42 activity, may possess anti-aging properties, its specific effects on the epidermis and dermis, as well as the underlying mechanisms in naturally aging mice, remain unclear. Our study revealed that CASIN demonstrated the ability to increase epidermal and...
‘Immortal’ creatures may reveal clues to contagious cancers
By studying how tumors are transmitted in hydras, researchers hope to learn how to predict or even prevent outbreaks in all sorts of wildlife
These lizards blow bubbles underwater and use them like scuba tanks
“Rebreathing” may let diving anole lizards stay underwater longer to evade predators