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Mechanistic Study of Platelet Membrane-Coated Resveratrol Nanosystem in Mitochondrial Dysfunction and Endothelial Senescence During Atherosclerotic Lesion Development via FOXM1 Activation

2 weeks 1 day ago
Atherosclerosis (AS) is closely linked to endothelial cell (EC) senescence and mitochondrial dysfunction, which impair vascular repair. Resveratrol (RSV) has antioxidant, anti-inflammatory, and pro-angiogenic effects, but its clinical use is restricted by poor bioavailability. This study aimed to construct a platelet membrane-coated resveratrol nanosystem (PM@RSV NPs) and investigate its mechanism of action in delaying the progression of AS by activating FOXM1 to improve mitochondrial function,...
Li Xiao

New molecular map reveals how the flu virus hijacks human cells

2 weeks 1 day ago
Scientists uncovered how influenza A commandeers human cells, including a surprising strategy that dissolves tiny structures in the nucleus and releases proteins the virus may use to reproduce. The detailed molecular map could reveal new drug targets and help researchers study dangerous flu strains such as H5N1.

This food compound may help vaccines work better in older adults

2 weeks 1 day ago
A naturally occurring compound found in foods such as wheat germ, mushrooms, and aged cheese may help older adults build stronger protection after vaccination. In a small pilot trial, researchers gave spermidine supplements to adults over 65 following their third COVID-19 vaccine dose. The biggest improvements appeared among people whose immune systems initially responded poorly, with higher antibody levels and stronger activity against several variants.

Scientists detect hidden skin damage before it becomes visible

2 weeks 1 day ago
Scientists have discovered a hidden warning sign of skin damage that appears before collagen fibers visibly thin, break, or lose their connections. Using advanced light-based techniques, the team found that collagen’s carefully organized molecular “handedness” can collapse even while the tissue still appears structurally intact and contains the same amount of collagen. This suggests that skin may begin deteriorating at a much deeper level long before conventional imaging can detect a problem.