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Hit a lab project glitch? Thinking about your thesis title like a storyteller can help you focus
AI cracks 80-year-old mathematics challenge — researchers are astonished
Major Ebola outbreak is escalating: what happens next
Neuroflix
Vanishing tongues and life on Mars: Books in brief
Popular weight loss drugs like Wegovy may also target arthritis inflammation
Researchers have discovered that the GLP-1 hormone targeted by drugs like Wegovy is present in very low amounts inside the joints of arthritis patients. That finding suggests high-dose GLP-1 medications could potentially reach the joints and influence inflammation directly, not just help through weight loss. Scientists say this could open the door to a completely new approach to arthritis treatment.
It’s official: Europe physicists plan to build 91-kilometer particle collider
The $19 billion Future Circular Collider would build on results from CERN’s Large Hadron Collider, currently the world’s largest
Meet the microbiologist and science advocate who’s headed to Congress
Jasmine Clark led a March for Science in 2017. She just won a Georgia primary for a safe Democratic House seat
U.S. agencies aren’t ready for the rising cost of making research papers free, report warns
Science agencies could soon face nearly $1 billion publishing bill, Congressional analysts find
“Zombie cells” aren’t always bad and that could transform anti-aging medicine
Scientists are uncovering a surprising truth about aging cells: some may damage the body, while others help protect it. The discovery is fueling a new wave of precision anti-aging therapies aimed at removing only the harmful “zombie” cells without disrupting the body’s natural repair systems.
Scientists discover a two-stage aging process that may cause cancer and arthritis
A new theory suggests many age-related diseases may actually start decades before symptoms appear. Researchers say early-life damage — from infections, injuries, or genetic mutations — can remain hidden until aging weakens the body’s ability to keep it under control. This could explain why conditions like cancer, osteoarthritis, and shingles suddenly emerge later in life.
Think you’re bad at languages? Experts say these 5 myths are to blame
Many people avoid learning a new language because they remember stressful grammar lessons or fear making mistakes. But language experts say communication, culture, and connection matter far more than perfection. Modern apps, entertainment, travel, and online communities have made learning easier, more social, and surprisingly fun.
Childhood junk food may rewire the brain for life
Eating too much junk food early in life may rewire the brain in ways that last into adulthood, even after switching to a healthier diet. Scientists found that high-fat, high-sugar diets changed feeding behavior and disrupted appetite-control regions in the brain. Excitingly, certain gut-friendly bacteria and prebiotic fibers appeared to help undo some of the damage.
Popular GLP-1 weight-loss drugs like Ozempic slash heart attack and stroke risk
A huge international review found that GLP-1 weight-loss drugs significantly reduce the risk of heart attacks, strokes, heart failure, and premature death over the long term. Researchers say these medications could become a major weapon against cardiovascular disease — not just obesity and diabetes.
Common pesticide linked to hidden brain damage, scientists warn
Scientists have uncovered alarming new evidence that a common insecticide may leave lasting marks on the developing brain before a child is even born. Researchers studying New York City children found that prenatal exposure to chlorpyrifos — a pesticide once widely used indoors and still used in agriculture — was linked to widespread brain abnormalities and weaker motor skills years later.
Scientists discover hidden weakness shared by hundreds of cancer mutations
Scientists have unveiled a powerful new tool called PerturbFate that could change how researchers tackle diseases driven by huge numbers of genetic mutations, including cancer and Alzheimer’s. Instead of trying to target every faulty gene individually, the system tracks how different mutations reshape cells over time and identifies the hidden “control hubs” where those pathways converge.
Nitric oxide drives proteomic diversity through alternative splicing
Redox signaling by nitric oxide (NO) is estimated to control a large part of the global proteome via S-nitrosylation (SNO-modification). Here, we report that RNA-binding proteins (RBPs) represent the most significantly enriched class of S-nitrosylation targets, with broad coverage of spliceosomal factors. We demonstrate that NO regulates alternative splicing (AS) and that S-nitrosylation of PTBP1, a central regulator of AS, can massively shift and contextually alter gene expression while further...
DTI-ALPS index and its association with neuroinflammatory and neurodegenerative biomarkers and tau-PET in Alzheimer's continuum
Glymphatic dysfunction may contribute to abnormal protein accumulation in Alzheimer's disease (AD). This study investigates associations between an indirect proxy of glymphatic function, plasma neurodegenerative and neuroinflammatory biomarkers, and tau-PET burden across the AD continuum. Data from 407 ADNI participants were utilized. Diffusion Tensor Image Analysis Along the Perivascular Space (DTI-ALPS) is used as a noninvasive proxy of glymphatic activity. Multivariable linear regression...
A hybrid CNN-GCN framework for interpretable Alzheimer's disease diagnosis from MRI scans
Medical image analysis for Alzheimer's Disease (AD) diagnosis faces two key challenges: capturing spatial dependencies between anatomically connected brain regions and providing clinically interpretable explanations. While Convolutional Neural Networks (CNNs) excel at local feature extraction and Vision Transformers handle long-range dependencies, neither explicitly models the relational structure between brain regions-critical for understanding disease progression. We propose a hybrid CNN-GCN...
TDP-43: a critical amplifier of Alzheimer's disease beyond amyloid and tau
TAR DNA-binding protein 43 (TDP-43) proteinopathy has recently emerged as a pivotal, yet underrecognized, contributor to the multifaceted neuropathology of Alzheimer's disease (AD). While amyloid-β and tau have long been established as cardinal pathological hallmarks, growing evidence delineates TDP-43 as a critical participant of neurodegeneration, intricately interwoven with amyloid and tau pathologies. TDP-43 mislocalization, post-translational modifications, and aggregation potentiate...