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Targeting brain rhythms to support cognition in aging: a systematic review and meta-analysis of tACS across healthy aging, mild cognitive impairment, and Alzheimer's disease
Cognitive decline is a major challenge in aging. Transcranial alternating current stimulation (tACS) modulates neural oscillations, potentially aiding cognition. Due to variation in late-life tACS studies, we conducted the first meta-analysis in older adults (≥ 60 years) to estimate pooled cognitive effects and determine if protocol parameters explain outcome variability. We searched Medline/PubMed, Embase, Cochrane Library, and ClinicalTrials.gov (up to September 17, 2025) for studies examining...
Associations between frailty severity and dietary quality and food security among older Korean adults: a cross-sectional study
CONCLUSIONS: These findings emphasize the importance of sex-specific nutritional interventions and stable food supply systems for preventing frailty in aging populations.
Impact of Metformin on Healthspan-Related Outcomes and Incidence of Diseases of Aging in People with Type 2 Diabetes Mellitus: A Systematic Review
Metformin use may be associated with reduced risk of all-cause mortality as well as prevent the onset of diseases of aging, namely cardiovascular diseases (CVD), cancer, and dementia. We systematically reviewed recent studies to determine whether metformin can promote healthspan in people with type 2 diabetes mellitus (T2DM). A comprehensive literature search was conducted using Medline, Embase, and Scopus for randomized controlled trials (RCTs) and cohort studies evaluating the effect of...
Distinct aging-related profiles of allocentric knowledge recall following navigation in an immersive, naturalistic, city-like environment
Aging-related declines in spatial navigation pose significant challenges for older adults' independence and quality of life. Among navigational deficits, older adults have been shown to demonstrate deficits in utilizing allocentric (i.e., world-centered) information and rely on egocentric (i.e., body-centered) cues during navigation, resulting in reference frame bias. We investigated naturalistic navigation performance and allocentric knowledge formation in younger adults (N = 30) and older...
Neural frequency-tagging of syllables in naturalistic speech is sensitive to background noise and age-related hearing loss
INTRODUCTION: Healthy aging is often accompanied by a loss of hearing sensitivity and a reduced ability to understand speech in both quiet and noisy environments. From a physiological perspective, neural oscillations are thought to fundamentally contribute to parse the speech signal into meaningful units and to extract linguistically relevant information at multiple hierarchical levels. Given that syllables are essential structural elements of the speech signal that recur with quasi-rhythmic...
Age-dependent vulnerability to spatial memory interference in APP/PS1 mice
CONCLUSION: These findings indicate that amyloidosis is associated with reduced reliability of spatial memory performance and impaired handling of competing spatial information, particularly under conditions requiring flexible updating of overlapping mnemonic representations. The results further suggest increased vulnerability to interference-related spatial memory deficits with age. Together, these findings support the utility of the OUL paradigm for studying memory updating impairments in...
Daily briefing: The brain builds a sentence neuron by neuron
Reaching for the cure as progeria research comes of age at the 12th international scientific workshop
Brexit tore apart European science — now the research rifts are healing
Is AI ruining our skills? Early results are in — and they’re not good
It slices! It dices! Sashimi-Bot handles seafood with ease
Clues to the sloth’s sloth found in its genome
Cell transplant across the tree of life hints at how animals emerged
EU Omnibus proposal increases pesticide risks
Science, Ahead of Print.
Indium-free perovskite/silicon tandem solar cells with tin oxide recombination layer and electrodes
Science, Ahead of Print.
Dynamic asymmetric strain imprinted into substrates by an oxide thin film
Science, Ahead of Print.
Researchers found 8 common food additives linked to high blood pressure and heart disease
A major study of more than 112,000 people found that eating foods containing common preservatives may be linked to a higher risk of high blood pressure and heart-related diseases. Researchers tracked participants for up to eight years and discovered that people consuming the highest amounts of certain preservatives had significantly greater risks of hypertension, heart attack, stroke, and other cardiovascular problems.
New NIH security rules for genomic data sets are slowing research, prompting workarounds
Data security experts say increased oversight is needed, but researchers are struggling to comply
With new law, European Union can more quickly greenlight gene-edited crops
Final political hurdle overcome, easing regulation of certain modified plants
Wolves are reconquering Europe. Can people learn to live with them?
As populations rebound, attacks on livestock and humans are fueling debate over the limits of coexistence