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Predictive value of different muscle power normalization methods for mobility limitations in community-dwelling older adults: A cross-sectional analysis from the longevity check-up 8+ study

2 weeks 1 day ago
CONCLUSIONS: Relative muscle power showed superior predictive performance for self-reported walking difficulty, as an indicator of mobility limitation, compared to other normalization methods. Future longitudinal studies are needed to confirm these findings and explore their relevance for other clinically meaningful outcomes.
Stefano Cacciatore

Therapeutic VEGFC treatment provides protection against traumatic-brain-injury-driven tauopathy pathogenesis

2 weeks 2 days ago
Traumatic brain injury (TBI) increases one's risk of developing Alzheimer's disease and tauopathy. Yet, the mechanisms linking TBI to neurodegenerative disease remain poorly defined. Mounting recent evidence indicates that defects in brain lymphatic drainage contribute to multiple neurodegenerative diseases. Here, we investigated whether promoting brain lymphatic drainage recuperation following TBI via treatment with the lymphangiogenic factor vessel endothelial growth factor C (VEGFC) mitigates...
Ana Royo Marco

Serum bile acids associated with brain hypometabolism in patients across the Alzheimer's disease continuum

2 weeks 2 days ago
The present study compares the predictive performance of serum bile acids with that of conventional Cerebrospinal Fluid (CSF) biomarkers of brain hypometabolism in the Alzheimer's disease (AD) continuum using [^(18)F]-Fluorodeoxyglucose Positron Emission Tomography ([^(18)F]-FDG-PET). Data were extracted from the Alzheimer's Disease Neuroimaging Initiative (ADNI). CSF biomarker data, serum bile acid measurements, and [^(18)F]-FDG-PET data were used. We studied 556 participants, including 185...
Ali Shushtari

Beyond quantity: Muscle quality as the cornerstone for sarcopenia diagnosis and healthy aging

2 weeks 2 days ago
This letter provides a critical reflection on the article "Sex- and age-related declines in muscle mass, strength, physical performance, and muscle quality among community-dwelling older adults: A cross-sectional study" (Asano et al., 2025). The study significantly advances our understanding of age-related muscle deterioration by examining multiple domains, including muscle mass, strength, physical performance, and quality, in a large cohort of Japanese older adults. Key findings highlight that...
Mifta Rizka