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This study tests the moderating role of essentialist beliefs about aging (i.e., perceptions of aging as a fixed versus malleable process) in the relationship between physical functioning and subjective well-being distinguishing between a) overall quality of life and b) health satisfaction among older adults in clinical care. We propose that essentialist beliefs serve as adaptive, palliative cognitions that help maintain high subjective well-being despite health challenges. In a sample of...

Early-life experiences can exert lasting impacts on brain function. While previous research has largely focused on early-life adversity, the long-term consequences of early-life enrichment on the aging brain remain poorly understood. In this study, we investigated the behavioral and molecular effects of communal nesting (CN, a model of early social enrichment, during postnatal day 2-9) in aged male mice. Behaviorally, CN-exposed mice preserved hippocampus-dependent recognition memory but...

Brain arteriolosclerosis, a primary pathology of cerebral small vessel disease, is common in older adults and is associated with lower cognitive and motor function and higher odds of dementia. The purpose of this study was to test the hypothesis that arteriolosclerosis is associated with lower diffusion anisotropy and higher trace of the diffusion tensor in white matter, independently of other age-related neuropathologies and visible white matter hyperintensities (WMH). In-vivo diffusion MRI and...

CONCLUSION: The findings of this study suggest that resistance training adaptations exhibit high task specificity in older adults, and significant improvements in functional outcomes can be achieved with elastic bands.

Aging is associated with a persistent, sterile inflammatory state called inflammaging, which contributes to endothelial dysfunction, immune dysregulation, and a gradual shift toward a procoagulant phenotype known as coagul-aging. Inflammation and coagulation are now understood as interconnected processes, linked by innate immune activation and thrombin production. Recent evidence highlights the vital role of endogenous nucleic acids, especially cytosolic and extracellular DNA, RNA, and RNA:DNA...

N6-methyladenosine (m6A) represents the most abundant internal RNA modification, and a key regulator of gene expression, yet its role in determining cell fate decisions such as senescence remains largely unexplored. Here, we identify the nuclear m6A reader YTHDC1 as a critical regulator of telomere homeostasis and senescence evasion in ovarian cancer. YTHDC1 expression was markedly elevated in advanced-stage tumors and correlated with poor patient survival. Functional investigation demonstrated...

Primary mitochondrial diseases (PMDs) affect approximately 1 in 4300 individuals and cause early-onset neuromuscular and multisystem dysfunction with reduced lifespan. They result from pathogenic variants in mitochondrial or nuclear DNA that impair oxidative phosphorylation. Cytochrome c oxidase (COX; complex IV) deficiency is a well-established cause of PMD, leading to a broad spectrum of phenotypes. COXFA4 (cytochrome c oxidase subunit FA4), formerly NDUFA4, is a nuclear-encoded COX subunit,...

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CONCLUSION: Psychosocial factors, particularly autonomy and control, significantly associated with sexual satisfaction in older adults with multimorbidity. These findings highlight the necessity of integrating mental health and subjective well-being into geriatric clinical care to support a holistic and humanized approach to healthy aging.

Ambient temperature is a primordial determinant of longevity across the animal kingdom, yet the molecular transducers that couple thermal cues to aging rates remain elusive. Here, we interrogate the transcriptomic and metabolomic landscapes of Drosophila melanogaster to decode the mechanisms of temperature-dependent lifespan extension. We find that thermal stress drives a profound remodeling of the transcriptome that surprisingly outpaces metabolic adaptation. Through this multi-omics...

A new study suggests melatonin supplements may help night shift workers boost their body's DNA repair processes, potentially offsetting some of the damage linked to working overnight. The findings are early but raise the possibility of a simple strategy to help reduce long-term health risks associated with night shift work.

A specially formulated tomato-soy juice packed with natural plant compounds may help calm inflammation linked to obesity, according to a new clinical study. Healthy adults with obesity who drank the juice daily for four weeks saw significant reductions in several key inflammatory proteins in their blood, while a control tomato juice did not produce the same effect.

Scientists discovered that sleep deprivation damages a key brain circuit responsible for social memory, making it harder to recognize familiar individuals. In laboratory studies, caffeine restored communication between neurons in this pathway and reversed the memory deficits caused by lost sleep. The effect was remarkably targeted, helping the impaired circuit recover without overstimulating normal brain function.

Scientists at Stanford may have uncovered a hidden reason our brains decline with age. Studying the ultra-short-lived turquoise killifish, researchers discovered that the cellular machinery responsible for building proteins begins to jam and malfunction over time. Tiny structures called ribosomes start colliding and stalling while reading genetic instructions, triggering a chain reaction that leads to faulty proteins and harmful clumps linked to diseases like Alzheimer’s.

Using cannabis edibles and alcohol together may make drivers far more impaired than either substance alone, according to new research from Johns Hopkins. Even more concerning, common field sobriety tests often failed to detect the cannabis-related impairment.

A sweeping global study found that chronic kidney disease now affects nearly 800 million people and has become one of the world's leading causes of death. Often silent in its early stages, the condition is also a major contributor to heart disease and may be even more common than current estimates suggest.

The brain must efficiently clear protein waste to maintain homeostasis, yet physiological drainage pathways remain poorly defined. Standard tracer injection approaches may not reflect endogenous efflux. Here, we develop a non-invasive genetic system to trace neuron-derived protein clearance from the brain to cerebrospinal fluid (CSF) and border tissues. We identify distinct drainage routes and border hotspots missed by tracer injection, confirmed by bioorthogonal labeling of endogenous neuronal...

The NLRP3 inflammasome contributes to a wide range of conditions from infections to Alzheimer's disease. NLRP3 forms an inactive decameric cage, that upon interaction with the trans-Golgi network (TGN) and microtubule organization center (MTOC), leads to inflammasome activation, yet whether non-decamer NLRP3 species form functional inflammasomes remains unclear. Here, we design a NLRP3 exon 3 deletion variant that forms low molecular weight NLRP3 assemblies. Spatially and dynamically highly...

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In Alzheimer's disease (AD), endogenous tau undergoes a pathogenic transition to form paired helical filaments (PHFs), but the cellular mechanisms driving this process have been elusive. Here, we identify the neuron-specific plasma membrane proteasome ('neuroproteasome') as a critical determinant of tau proteostasis. Selective inhibition of neuroproteasome function rapidly triggers the de novo formation of endogenous, sarkosyl-insoluble tau PHFs in primary neurons and mouse brain, which share...