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In Other Journals

2 weeks ago
Science, Volume 391, Issue 6783, Page 364-365, January 2026.
Corinne Simonti, and Jesse Smith, Bianca Lopez, Yevgeniya Nusinovich, Joana Osório, Corinne Simonti, Ian S. Osborne, Jack Huang, and Jelena Stajic

Evaluating Senescence-Targeted Approaches in Alzheimer's Disease: What We Know and What Lies Ahead

2 weeks ago
Alzheimer's disease (AD) is a progressive and irreversible neurodegenerative disease, which represents the most prevalent dementia worldwide. Although amyloid-β (Aβ) and tau pathology have been the classic focus of treatment, accumulating evidence indicates that ageing-associated cellular senescence plays a central role in AD pathogenesis. Senescent neurons, astrocytes, microglia and endothelial cells accumulate in the ageing and Alzheimer's brain and adopt a senescence-associated secretory...
Pratik Prashant Doshi