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Sex-specific circadian and behavioral phenotypes in aged growth hormone receptor knockout mice

2 weeks 1 day ago
Growth hormone (GH) exerts complex effects on metabolism, cognition, and overall physiological well-being, and its secretion is highly regulated by the circadian clock. The Growth Hormone Receptor Knockout (GHR-KO) mouse, a model of GH insensitivity, characterized by chronically elevated circulating GH, provides a unique opportunity to examine the consequences of disrupted GH signaling during aging. Given the close relationship between circadian rhythmicity and GH secretion, we investigated sex-...
Sean M Hicks

Barriers to Research Participation Among Older Rural Veterans: Early Insights to Strengthen Frameworks for Age-Inclusive Research

2 weeks 1 day ago
CONCLUSIONS: Research investigators, staff, Veterans, and caregivers identified several cross-cutting challenges that are important in the recruitment and retention of older rural Veterans in research. The adaptations proposed here demonstrate that the 5Ts Framework can extend to intersectional aging populations, providing a model for broader representation in research.
Justine Seidenfeld

Distinct Transposable Element Transcript Patterns in Microglia Across Aging and Alzheimer's Disease

2 weeks 1 day ago
Microglia, the brain's resident immune cells, are transcriptionally diverse and highly dynamic, but during aging and disease they lose their transcriptomic flexibility and adopt a chronically activated state that is associated with neuroinflammation and pathology. An emerging transcriptomic process that is also increasingly implicated in brain aging, neuroinflammation, and disease is the dysregulation of transposable elements (TEs), repetitive genomic sequences with the potential to cause...
Randy A Grant

A surprising triple treatment completely clears hiv in newborn primates

2 weeks 1 day ago
Researchers have found a striking new way to potentially eliminate HIV soon after infection using a one-time combination of three therapies. In newborn nonhuman primates treated within three days of exposure, the regimen—standard antiretroviral drugs, broadly neutralizing antibodies, and the experimental antibody leronlimab—completely cleared the virus, even though none of the treatments could do so alone.

Human brain cells are far more powerful than scientists thought

2 weeks 1 day ago
A single human brain cell may be far more powerful than scientists once realized. Researchers found that cortical neurons can perform remarkably complex computations, giving them capabilities more like tiny biological computers than simple on-off switches. This could help explain why the human brain supports abilities such as language, imagination, and mathematics.

Why your brain keeps making the same decisions – even when better options exist

2 weeks 1 day ago
Why do we keep making the same choices even when better options are available? Researchers found that simply repeating a decision can reshape what we prefer, causing familiar choices to feel better than alternatives. Instead of weighing every option from scratch, the brain often remembers what it chose before and repeats it. That shortcut may help explain many everyday habits and seemingly irrational decisions.