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Testosterone levels decline progressively with age from the third decade of life, impairing spermatogenesis and contributing to age-related disorders, underscoring the importance of enhancing endogenous testosterone production. DNA methyltransferase 1 (DNMT1) promotes testosterone synthesis in Leydig cells (LCs), yet the underlying mechanism remains unclear. Here, we found that DNMT1 expression is downregulated in aging rat testes and senescent LCs in vitro, correlating with reduced testosterone...

Your daily routine could have a bigger impact on your ability to handle stress than you realize. A Binghamton University study of approximately 400 college students found that eating breakfast regularly, exercising, sleeping well, and taking fish oil were associated with greater psychological flexibility, which helps people adapt to stressful situations. Poor sleep and unhealthy eating habits, meanwhile, were linked to lower flexibility and resilience.

Thousands shared their stories for a new study of faculty attrition