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CONCLUSIONS: This preliminary study demonstrates the feasibility of estimating longer-term LTC cost trajectories based on early service utilization patterns, highlighting the potential role of care managers in shaping future cost trajectories. These findings may inform efforts to enhance the fiscal sustainability and quality of Japan's LTCI system.

The Greenland shark (Somniosus microcephalus) is known for its slow metabolism and deep-sea habitat. It is thought to be the longest-lived vertebrate on Earth, with an estimated lifespan of 392 ± 120 y. Despite its remarkable longevity and unusual lifestyle, no genomic studies are yet available for this species. Here, we report a chromosome-level assembly of the Greenland shark genome, which is 5.9 Gb in size with an N50 length of 233 Mb and a completeness score of 96.7%. Our analyses of gene...

Alternations of DNA methylation occur in aging, which is regulated by DNA methyltransferases (DNMTs). In this study, we show that even though the transcription of DNMT1, the only enzyme that maintains DNA methylation in the mammalian genome, is reported to be decreased in an age-dependent manner, the decrease of Dnmt1 mRNA does not result in a decrease of its protein. Instead, DNMT1 protein is increased in aged mouse tissues, which is responsible for the methylation of genes related to...

Oxidative stress and DNA damage caused by hydroquinone (HQ) increases the aging process, whereas antioxidants encourage longer lifespan by decreasing oxidative stress, making it ideal for research on mitigation of oxidative stress induced toxicity. Our study, explored 2'-hydroxyflavanone (2HF) and quercetin (QE) effects on HQ exposed Drosophila through gut toxicity assays (trypan blue) and survivorship (Kaplan-Meier plots) along with fertility and fecundity of female flies. Effects of the...

Population-based preventive trials are rare in psychiatry, especially in an aging population, and the effects of potentially modifiable lifestyle risk factors such as diet on mental health outcomes are largely unexplored. This study aimed to estimate the effects of an anti-inflammatory diet on mental health outcomes in older adults and the potential effect of lifestyle modification. A preventive population-based target trial was emulated using data from the ASPirin in Reducing Events in the...

CONCLUSION: Based on the findings, this study recommends implementing dynamic regulatory strategies aligned with different development stages, formulating region-specific policies that account for spatial heterogeneity, and adopting targeted interventions focusing on key influencing factors, in order to systematically promote the high-quality coordinated development of healthcare services and older adults care services in China.

CONCLUSIONS: Higher daily step counts are independently associated with better quality of life, knee-specific function, and physical performance among community-dwelling Thai older adults. A target of 6,000-9,000 steps per day appears clinically meaningful and pragmatically attainable. Daily step count may serve as a practical and scalable metric to guide healthy aging strategies in Asian populations.

CONCLUSION: In this sample of older adults, worse hearing thresholds were associated with poorer performance on cognitive screening instruments and with lower hearing-related quality of life. These findings support further investigation of early hearing assessment and rehabilitation in older adults, and indicate the necessity of effective and timely auditory amplification, even in individuals with moderate hearing loss.

CONCLUSIONS: Older adults with pre-frailty and frailty value online nutrition education but require resources that are personalised, credible, and accessible across diverse learning needs. Findings highlight opportunities to embed consumer voices in resource design and provide future directions for refining the current online nutrition resource. This research contributes to evidence on consumer-informed digital nutrition education to support autonomy, dietary self-management, and healthy ageing.

A large European study revealed that a lower-calorie Mediterranean diet paired with exercise and coaching dramatically reduced the risk of type 2 diabetes. Participants who made these lifestyle changes were 31% less likely to develop the disease over six years. They also lost more weight and trimmed their waistlines compared to those following a standard Mediterranean diet alone.

Analysis charts evolution of the joint that made our species so nimble