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Study reveals role of “fine-grained” ancestry in predicting response to painkillers, statins, and other drugs

Europe’s Solar Orbiter is helping researchers understand what causes the Sun to blast out radiation and particles

Enigmatic organism known as Prototaxites cannot be fungus, new analysis finds

An unprecedented assault has forced researchers to rethink their advocacy tactics

Mementos may have reinforced vast social networks during turbulent times

Understanding complex interactions in biomedical networks is crucial for advancements in biomedicine, but traditional link prediction (LP) methods are limited in capturing this complexity. We present BioPathNet, a graph neural network framework based on the neural Bellman-Ford network (NBFNet), addressing limitations of traditional representation-based learning methods through path-based reasoning for LP in biomedical knowledge graphs. Unlike node-embedding frameworks, BioPathNet learns...

Senescent cells (SCs) accumulate with aging and contribute to the development of age-related pathologies. These cells evade apoptosis through upregulation of senescent cell anti-apoptotic pathways (SCAPs), making their selective elimination, a strategy termed senolysis, a promising therapeutic avenue. Proteolysis-targeting chimeras (PROTACs) represent an emerging class of bifunctional molecules that exploit the ubiquitin-proteasome system to degrade specific target proteins. By concurrently...

Age-related deterioration of the sensorimotor system can impair proprioception. This study aimed to characterize age-related changes in the sense of position and movement. Three experiments involved two groups of participants (29 young adults and 26 older adults) to i) evaluate the performance in a position matching task (Experiment 1), ii) assess the perception and reproduction of an illusory movement evoked by proprioceptive stimulation (mechanical muscle-tendon vibration) (Experiment 2), and...

Aging is characterized by progressive physiological decline and increased vulnerability to metabolic and inflammatory disturbances. Palmijihwang-hwan (PM), a traditional East Asian herbal formula, has been used empirically for age-related complaints, but its mechanistic basis remains unclear. Here, we evaluated the effects of early-onset PM administration (starting at 2 months of age) on longevity-related phenotypes and metabolic regulation. PM significantly prolonged lifespan in Caenorhabditis...

Sperm aging impacts male fertility and offspring health, highlighting the need for reliable aging biomarkers to guide reproductive decisions. However, the molecular determinants of sperm fitness during aging remain ill-defined. Here, we profiled sperm small non-coding RNAs (sncRNAs) using PANDORA-seq, which overcomes RNA modification-induced detection bias to capture previously undetectable sncRNA species associated with mouse and human spermatozoa throughout the lifespan. We identified an...

CONCLUSION: These findings suggest that while aging is associated with some types of cognitive decline, it also fosters unique cognitive strengths that can enhance certain aspects of creativity. The findings of the current study underscore the need to reconsider stereotypes about aging and creativity and highlights the interplay of executive and associative processes in creative ideation.

CONCLUSIONS: Medication adherence among rural elderly with CDs remains suboptimal and is shaped by factors spanning individual, interpersonal, organizational, and community levels. Interventions should integrate these multilevel influences to strengthen adherence and chronic disease management in resource-limited rural settings.

Anti-amyloid drugs modestly slow Alzheimer's disease progression, albeit with uncertainty of sustained benefit, particularly as they cause paradoxical acceleration of brain volume changes. Here, we examine explanations for these volume changes and argue for transparent release of clinical trial data.

The conserved Ess1 prolyl isomerase (PIN1 in human) binds the carboxy-terminal domain (CTD) of RNA Pol II, and plays multiple roles in transcription regulation. Consistent with an essential role of the human PIN1 in telomere maintenance, previous screenings have identified the yeast Ess1 as a telomere length maintenance gene. Here, we provide evidence that Ess1 is involved in regulating both telomere transcription and replication. We find that depletion of Ess1 leads to a failure in...

Improvements in wildlife husbandry mean that many zoo animals are living longer. This has put pressure on the finite holding capacity of zoos, which has often been addressed through a curtailing of reproduction to reduce population growth rates. Here, we explore how such actions have impacted the demographic trends of 774 mammal populations in European and North American zoo populations between 1970 and 2023. Irrespective of whether the data are clustered by region, taxonomic group, conservation...

Progressive lung fibrosis is linked to aging-related dysfunction in fibroblasts, which remains poorly understood. To investigate the alterations in fibroblasts, particularly the molecular programs driving this profibrotic evolution in the aging lung, we isolated senescent lung fibroblasts from aged mice. We observed aberrant vimentin aggregates, which correlate with accelerated fibroblast senescence. CRISPR-based screening identified calumenin as a chaperone protein essential for vimentin...