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NIH’s arguments opposing the union don’t hold up, ruled a federal entity that oversees labor relations

Exercise triggers bone cells called osteocytes to secrete antiaging chemicals in mice

A surprising discovery at UC San Diego suggests that chronic lower back pain may become deeply embedded in the brain's sense of personal identity. Researchers found that movement-triggered pain activates a brain network associated with self-awareness and memories, even though ordinary acute pain typically shuts this network down. This unexpected difference could explain why conventional pain medications often provide limited relief and why fear, anticipation, and past experiences can intensify chronic pain.

Scientists have identified a weakened brain signal that may connect several seemingly unrelated symptoms of schizophrenia, including sensory processing difficulties, disorganized speech, and greater symptom severity. The surprising discovery could help explain the disorder's underlying mechanisms and potentially lead to earlier detection and new treatments.

A study of nearly 13,000 adults found that people consuming the most artificial sweeteners experienced a 62% faster decline in memory and thinking skills, equivalent to approximately 1.6 additional years of brain aging. Six popular sweeteners were linked to faster cognitive decline, raising concerns about the long-term brain health effects of common sugar substitutes, although causation was not established.

Rules governing credit and responsibility for machine-written papers may need a reboot

Getting more daylight could be linked to a surprisingly powerful benefit for brain health. In a study of more than 87,000 adults, researchers found that higher daytime light exposure was associated with a 16% lower risk of dementia, with longer exposure to bright light linked to even greater reductions. Remarkably, getting less than 42 minutes of bright daylight daily was a stronger predictor of dementia than six established risk factors.

Cranberry juice may offer an unexpected benefit beyond its reputation for helping prevent urinary tract infections: protecting teeth from decay. Researchers at the University of Illinois Chicago discovered that pure, unsweetened cranberry juice slowed the regrowth of dental plaque bacteria and reduced their production of acids that damage tooth enamel. The secret may lie in naturally occurring compounds called proanthocyanidins, which interfere with harmful bacteria.

In this issue of Cell, Brioschi et al. identify cellular musculoaponeurotic fibrosarcoma (cMAF) as a key regulator of brain perivascular macrophages that supports cerebrovascular function through insulin-like growth factor 1 (IGF1) production. This cMAF-IGF1 program is enhanced in Alzheimer's disease (AD), potentially reflecting a protective response that is lost in APOE4 carriers.

Alzheimer's disease (AD) is characterized by marked heterogeneity in the timing and extent of neuronal dysfunction and degeneration. Specific neuronal populations, including entorhinal cortex layer II stellate cells, hippocampal CA1 pyramidal neurons, basal forebrain cholinergic neurons, locus coeruleus noradrenergic neurons, and prefrontal parvalbumin interneurons, show different combinations of functional, pathological, and degenerative vulnerability during disease progression. The strength...

In this issue of Cell, Grońska-Pęski et al. examine how calorie restriction (CR) affects DNA mutation rates. While CR lowers the accumulation of mutations, this effect does not scale with the degree of lifespan extension. Their work raises important new questions about how CR impacts the causal mechanisms of aging.

Autocrine signaling through vascular endothelial growth factor receptor-1 (VEGFR-1) reprograms T cell metabolism upon TCR stimulation. We found that mice bearing conditional deletion of Flt1 (encoding VEGFR-1) in T cells developed spontaneous obesity with advancing age. Analyses of lymphoid and metabolic tissues identified a VEGFR-1^(+) T follicular helper (Tfh) population in Peyer's patches and mesenteric lymph nodes. Flt1 deletion impaired Tfh fitness and reduced secretory IgA in the gut,...