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Algorithmic Inequity in Aging: How AI-Driven Healthcare Decision Tools Amplify Socioeconomic Disparities in Health Outcomes Among Older Adults

2 weeks 2 days ago
Background and ObjectivesArtificial intelligence (AI) is increasingly used in healthcare decision-making to improve clinical efficiency and patient risk assessment. However, emerging evidence suggests these tools may disadvantage older adults from lower socioeconomic backgrounds, potentially worsening health disparities. This scoping review examines how AI-driven healthcare decision tools affect health outcomes among socioeconomically disadvantaged older adults.MethodsFollowing the Arksey and...
Isaac Eshun

Oral LNAD+ rapidly elevates whole blood intracellular NAD and metabolic flux without elevating plasma NAD: evidence from a randomized controlled trial

2 weeks 2 days ago
Declines in nicotinamide adenine dinucleotide (NAD+) are linked to metabolic stress accompanying aging and disease. While precursor-based approaches elevate systemic NAD, their clinical translation can be constrained by biosynthetic bottlenecks and first-pass metabolism. RENEWAL-NAD+ (ClinicalTrials.gov NCT07336836; retrospectively registered 01/04/2026) was a double-blind, randomized, placebo-controlled Phase 0/1b trial in healthy adults aged 45-75 years (60 randomized; primary analysis n = 50)...
Sergey A Kornilov

Dual decline in gait and cognition as a high-risk clinical phenotype: differential associations with cerebral amyloid-<em>β</em> deposition and the apolipoprotein E ε4 allele and implications for integrated assessment

2 weeks 2 days ago
CONCLUSION: The co-occurrence of slow gait and mild cognitive impairment (MCI-SG) represents a distinct high-risk clinical phenotype strongly linked to AD pathology. Aβ and APOE ε4 show differential associations across the gait-cognitive spectrum. Integrated assessment of gait and cognition improves risk stratification in older adults and may guide early intervention strategies.
Chenxi Ren

Methodological innovations in studying marginalized populations in research on neurodegeneration and ageing

2 weeks 2 days ago
Underrepresented populations, often characterized by minority ethnicity, sex/gender or low socioeconomic status, have a higher risk burden and more adverse lifetime experiences of conditions negatively impacting cognitive health than better represented populations. There are several methodological challenges of research in and with marginalized populations that hinder research on improvements to their cognitive health. This review aims at presenting challenges of recruitment, data collection,...
Anja K Leist

Inactivation of V-ATPase induces autophagy and ectopic Notch activation to promote intestinal stem cell differentiation in adult <em>drosophila</em> midgut

2 weeks 2 days ago
The self-renewal and differentiation of stem cells are tightly controlled to maintain tissue homeostasis. Failure in stem cell maintenance results in stem cell depletion and precocious aging. However, how stem cells are maintained still remains not fully understood. Here, through a large-scale RNAi screen for maintenance and proliferation of adult Drosophila intestinal stem cells (ISCs), we identify several subunits of V-ATPase including Vha68-2/ATP6V1A, required for ISC proliferation,...
Zhengran Li

Targeting chaperone-mediated autophagy by nutritional interventions mitigates age-related cardiac fibrosis and diastolic dysfunction

2 weeks 2 days ago
Cardiac fibrosis, a major pathological hallmark of aging that leads to heart failure, is characterized by excessive collagen deposition. Our knowledge of what sustains collagen synthesis in the aging heart is still very preliminary. Here, we uncover a central role for chaperone-mediated autophagy (CMA), a selective lysosomal degradation pathway, in this process. We demonstrate that CMA is suppressed in the aging heart, which promotes collagen overproduction in fibroblasts, whereas enhancing CMA...
Ziwen Wang