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Cerebral amyloid angiopathy (CAA) is a neurodegenerative condition characterized by amyloid-β (Aβ) deposition in small vessel walls, often coexisting with Alzheimer's disease due to impaired Aβ clearance. However, the spatial distribution of Aβ within the human brain remains unclear as the vascular network's complexity and scale hinder visualization by conventional thin-slice analysis. To address this, we performed three-dimensional (3D) volumetric imaging of the cerebrovascular network and Aβ...

Ovarian aging, recognized as one of the initial signs of systemic aging, is marked by a progressive reduction in both the number and quality of oocytes, which has a profound effect on female fertility. In spite of the advancements in assisted reproductive technologies, these methods fail to tackle the fundamental molecular mechanisms that drive ovarian senescence. Recent surveys have underscored the significant role of epitranscriptomic regulation, especially the N6-methyladenosine (m6A)...

CONCLUSION: This review demonstrated the potential applicability and value of obstetric teleultrasound. This novel care model is everchanging and new devices/systems capable of telesonography are of clinical and scientific relevance. Presently, additional high-quality evidence is required, particularly using teleultrasound in a clinical context, whilst ensuring sufficient methodological detail and consistent outcome reporting.

Older adults are susceptible to infections in part due to waning of immune memory. To uncover mechanisms of a long-lasting immune memory, we contrasted varicella zoster virus antigen-specific memory T cell responses in adults vaccinated at young (<20 years) or older age (>50 years) with a live-attenuated vaccine conferring durable protection only when given at young age or with an adjuvanted component vaccine eliciting long-lasting immunity in older adults. Unlike VZV-specific CD4^(+) T cells,...

The first 5 hours of aging in biomass burning plumes can strongly affect ozone photochemistry. We examine how volatile organic compounds (VOCs), nitrogen oxides, and nitrous acid influence hydroxyl radical, ozone, and peroxyacetyl nitrate (PAN) based on three aircraft campaigns over the United States. Our analyses reveal variable, highly elevated hydroxyl radical concentrations in the first 2 hours, resulting in evident fire-to-fire variability in VOCs oxidation and in ozone and PAN production....

CONCLUSIONS: EWGSOP2 algorithm is a valid tool even in hospitalized older patients, and each step enhances the predictivity of the algorithm; however, SARC-F and muscle strength can still be valuable tools for negative clinical outcomes when body composition data are not available.

New DNA analysis links Deep Maniots to Greece’s premedieval past

After a 12-year affiliation intended to address financial woes, the Marine Biological Laboratory returns to independence

Efforts to correct historic undercount of poor, immigrant, rural, and minority populations are at risk, critics say

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