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Single-nucleus transcriptome-wide association study of human brain disorders
Gravitational torque drives multidecadal variations in length of day
The anthropogenic fingerprint on emerging infectious diseases
The gene-regulatory evolution of the human skeleton
Competition heats up in the regenerative-medicine ranks
Bank accounts reveal the fingerprints of abusive financial control
Chiral oxazolidinones <i>via</i> biocatalytic aziridination of unactivated alkenes
Author Correction: Large recoverable elastic energy in chiral metamaterials via twist buckling
How to stay smart in the age of AI: the science of critical thinking
In praise of human teachers: universities must resist outsourcing everything to AI
Huge hoard of metal bars hints at vast Iron Age trade
Project will harness technology to track Amazon biodiversity in real time
Leaders of $100 million effort will use automated detection methods and computer models to monitor species’ trends
Bones link 10,000-year-old temple complex to a village, not a ‘skull cult’
Landslides, not rituals, may have scattered skulls and bones at Turkey’s famed Göbekli Tepe site
This new drug could break cancer’s resistance to treatment
A new experimental drug called CS18 may help break through cancer drug resistance by disabling several of the defenses tumors use to survive treatment. It strengthened existing therapies, restored drug sensitivity in resistant lung cancer cells, and slowed tumor growth in animal models.
Coffee doesn’t have to keep you awake to disrupt your sleep
Caffeine may make sleep less restorative even when you fall asleep normally and stay in bed for eight hours, with EEG recordings revealing fewer of the slow brain waves associated with deep sleep. Individual sensitivity varies dramatically, meaning even caffeine consumed earlier in the day could affect nighttime recovery for some people.
This emerging treatment could help people avoid knee replacement surgery
A minimally invasive procedure called genicular artery embolization could offer a new middle ground between conservative treatments and knee replacement for osteoarthritis. By blocking tiny blood vessels associated with inflammation, GAE can significantly reduce pain, with some patients reporting little or no pain afterward. Studies suggest the benefits may last two to four years in people who respond well.
How the ‘fire amoeba’ withstands temperatures that would kill most complex life
Incendiamoeba cascadensis may survive in volcanic lakes thanks to a static blanket that shields its proteins from the heat
Blood proteomics of menopause map to brain aging and dementia risk
Menopause is a hallmark process in biological aging that has been implicated in later neurodegenerative risk, but the pathways underlying this connection remain unclear. Here we used blood proteomics data from several cohorts to identify biological changes associated with menopause and its links to brain aging. In n = 80 rigorously staged (STRAW+10) pre-, peri- and postmenopausal women (aged 43-58 years) with serum NULISAseq proteomics, we show that spontaneous menopause is characterized by...
Cellular senescence and the SASP in skeletal ageing: convergent mechanisms of progressive bone loss in osteoporosis
Skeletal ageing involves changes in endocrine regulation, mechanical loading and cellular function that can impair bone remodelling. Cellular senescence and the senescence-associated secretory phenotype (SASP) have emerged as mechanisms that help close this gap. In the ageing bone microenvironment, senescent osteocytes, mesenchymal stem cells, osteoblasts, immune cells, and vascular endothelial cells secrete pro-inflammatory cytokines, chemokines, matrix metalloproteinases, and Wnt antagonists...
Blood proteomics of menopause map to brain aging and dementia risk
Menopause is a hallmark process in biological aging that has been implicated in later neurodegenerative risk, but the pathways underlying this connection remain unclear. Here we used blood proteomics data from several cohorts to identify biological changes associated with menopause and its links to brain aging. In n = 80 rigorously staged (STRAW+10) pre-, peri- and postmenopausal women (aged 43-58 years) with serum NULISAseq proteomics, we show that spontaneous menopause is characterized by...