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The Construct Validity of the Life-Space Assessment in the Canadian Longitudinal Study on Aging (CLSA)
CONCLUSION: The LSA can be used to differentiate between known groups. However, there is limited evidence of its convergent validity as its relationship with other measures of actual mobility, perceived mobility, and locomotor capacity for mobility was weak. Future studies need to assess the convergent validity of the LSA against different comparator measures before its use among community-dwelling Canadians.
Rocked by aid cuts, Malawi rethinks how it funds health
Services for mothers and children continue to suffer in the meantime
Daily briefing: Naked mole rat queens use a smell to stay on top
CRISPR gets a power boost from AI-designed ‘molecular scissors’
US politicians push agencies to restrict research collaboration with China
‘Explosive diarrhoea’ outbreak grips US: how researchers are hunting its source
AI is set to completely transform cybersecurity — here’s how researchers must prepare
Trained immunity links hematopoietic stem cell aging to aging-associated inflammation
Will making ‘replication studies’ easier to find help science self-correct?
A global capital for AI safety is emerging — and it’s not in Silicon Valley
Why do astronauts’ bodies waste away? Space-station study points to mitochondria
Helium escaping from the atmosphere of a nearby rocky exoplanet orbiting in a habitable zone
Science, Ahead of Print.
Preferred synthesis of armchair transition metal dichalcogenide nanotubes
Science, Ahead of Print.
De novo design of orthogonal far-red, orange, and green fluorophore-binding proteins for multiplexed imaging
Science, Ahead of Print.
A cinnamyl alcohol dehydrogenase–like scaffold organizes monoterpenoid indole alkaloid biosynthesis
Science, Ahead of Print.
Scientists finally solved how a common gut bacterium triggers colon cancer
Researchers solved a long-standing mystery behind how a bacterial toxin associated with colorectal cancer damages the colon. The toxin first binds to a receptor called claudin-4, giving it access to attack the cells' protective barrier. After identifying this weak point, the team designed a decoy protein that successfully blocked the toxin in mice. The discovery could pave the way for new therapies to prevent inflammation and colon tumors.
Alzheimer’s trial results lend momentum to strategies targeting tau
First drug to lower the protein and slow cognitive decline creates buzz despite puzzling data
More than 400 sick as CDC searches for the source of a mystery outbreak
A growing Cyclospora outbreak has sickened more than 400 people in four states, and investigators are still searching for the contaminated food responsible. The CDC warns the actual number of cases is likely much higher and urges anyone with symptoms to seek medical care.
DNA from African graves provides surprising window into slave trade
Adults and children were taken from deep within continent’s interior, genetic material from remote island of St. Helena suggests
Astronomers spot first atmosphere around a potentially habitable alien world
Detecting escaping helium from LHS 1140b is important step in search for life beyond our Solar System