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Aging involves morphological and functional changes across different organs, but how these changes are linked among the different organs remains to be elucidated. Here, we uncover a central role of platelets in systemic aging. In aged mice, the levels of platelet-secreted pro-inflammatory factors (PSPF) increased greatly in the serum and platelets, leading to a diffuse increase of platelet infiltration in the brain, liver, lung, kidney, and aortic root. The RNA-binding protein HuR/ELAVL1, a...

Deoxyribonucleic acid provides unmatched information density and longevity for data storage, yet its easy amplification by polymerase chain reaction enables unauthorized replication at negligible cost. We introduce ZAT-DNA, which encodes information in patterns of canonical adenine and noncanonical 2-aminoadenine. As DNA polymerases cannot distinguish adenine from 2-aminoadenine, polymerase-based amplification erases these patterns, enforcing molecular-layer non-replicability intrinsic to the...

By eliciting lung necrosis, which enhances aerosol transmission, Mycobacterium tuberculosis (Mtb) sustains its long-term survival as a human pathogen. In studying the human-like necrotic granuloma lesions characteristic of Mtb-infected B6.Sst1S mice, we found that lung myeloid cells display elevated senescence markers: cell cycle arrest proteins p21 and p16, the DNA damage marker γH2A.X, senescence-associated β-galactosidase activity, and senescence-associated secretory phenotype (SASP). These...

Metabolism unfolds within specific organelles in eukaryotic cells. Lysosomes are highly metabolically active organelles, and their metabolic states dynamically influence signal transduction, cellular homeostasis and organismal physiopathology. Despite the importance of lysosomal metabolism, a method for its in vivo measurement is currently lacking. Here we report a fluorescence-detected mid-infrared photothermal microscope (FILM) implemented with optical boxcar demodulation, artificial...

CONCLUSION: The DoMAP model provides a structured framework for capturing the diverse etiologies of malnutrition in older patients. This study emphasizes the multifactorial nature of malnutrition in hospitalized patients, with low intake and poor appetite emerging as predominant drivers.

Recent advances in van der Waals materials have sparked renewed interest in the impact of dimensionality on magnetic phase transitions. Although ordered magnetic phases have been demonstrated to survive in the two-dimensional (2D) limit, the quest for a spin glass with quenched magnetic disorder in lower dimensions has proven elusive. Here, we provide evidence of a spin glass emerging from randomly distributed Fe atoms in Fe(3)GeTe(2) (FGT). ac magnetic susceptibility displays a strong frequency...

Aging researchers and the removal of retirement policies yield decreased disruptive innovation in science.

CONCLUSION: In healthy older adults, adherence to a healthy lifestyle was associated with a greater likelihood of surviving free from disability and dementia and was prospectively linked with a prolonged healthspan and a compression of morbidity, highlighting its potential importance in promoting healthy aging.

Cellular senescence arises through replicative exhaustion or acute stress, yet whether these distinct triggers share a reproducible transcriptional organization has remained unresolved. Seven public human fibroblast RNA-seq datasets were integrated across both trigger types, moving from differential expression through Gene Ontology and Reactome enrichment to protein-protein interaction network embedding within a single harmonized framework. Both triggers converged on concordant repression of...

Aging doesn’t just add fat—it redistributes it in risky ways, pushing more into the abdomen where it can harm health. Scientists found that testosterone plays a key role in this shift. In older women recovering from hip fractures, a testosterone gel combined with exercise helped prevent the usual rise in dangerous visceral fat. The result could point to a powerful new strategy for improving recovery and long-term health.

Past studies of Andes virus offer scant evidence on transmission risks, and have sparked debate

Science, Volume 392, Issue 6798, May 2026.

Science, Volume 392, Issue 6798, May 2026.

Science, Volume 392, Issue 6798, May 2026.

Science, Volume 392, Issue 6798, May 2026.

Science, Volume 392, Issue 6798, May 2026.

Science, Volume 392, Issue 6798, May 2026.