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The emergence and diversification of dog morphology

1 week 6 days ago
Science, Volume 390, Issue 6774, Page 741-744, November 2025.
Allowen Evin, Carly Ameen, Colline Brassard, Sophie Dennis, Ekaterina E. Antipina, Vincent Bonhomme, Myriam Boudadi-Maligne, Kate Britton, Francisco Gil Cano, Ruth F. Carden, Julien Claude, Lídia Colominas, Stefan Curth, Sergey Egorovich Fedorov, Joan…

Clinically ready magnetic microrobots for targeted therapies

1 week 6 days ago
Science, Volume 390, Issue 6774, Page 710-715, November 2025.
Fabian C. Landers, Lukas Hertle, Vitaly Pustovalov, Derick Sivakumaran, Cagatay M. Oral, Oliver Brinkmann, Kirstin Meiners, Pascal Theiler, Valentin Gantenbein, Andrea Veciana, Michael Mattmann, Silas Riss, Simone Gervasoni, Christophe Chautems, Hao Ye,…

Single-nucleus multi-omics identifies shared and distinct pathways in Pick's and Alzheimer's disease

2 weeks ago
The study of transcriptomic and epigenomic variations in neurodegenerative diseases, particularly tauopathies like Pick's disease (PiD) and Alzheimer's disease (AD), offers insights into their underlying regulatory mechanisms. Here, we identified critical regulatory changes driving disease progression, revealing potential therapeutic targets. Our comparative analyses uncovered disease-enriched noncoding regions and genome-wide transcription factor (TF) binding differences, linking them to target...
Zechuan Shi

iPEX enables micrometre-resolution deep spatial proteomics via tissue expansion

2 weeks ago
The number of spatial omics technologies being developed is increasing¹. However, a missing tool is one that can locate proteins in tissues in an untargeted manner at high spatial resolution and coverage. Here we present in situ imaging proteomics via expansion (iPEX), which integrates isotropic tissue magnification² with matrix-assisted laser desorption/ionization (MALDI) mass spectrometry imaging. iPEX provides scalable spatial resolution down to the micrometre scale and substantially...
Fengxiang Wang

circHERC1-A telomerase activator

2 weeks ago
Telomerase, crucial for maintaining telomere integrity and genomic stability, is typically silenced in somatic cells with advancing age. In this study, we identify circHERC1 as a regulator of telomerase reverse transcriptase (TERT) transcription. Specifically, circHERC1 binds to the TERT promoter, facilitating the recruitment of RNA polymerase II and c-Fos, thereby activating TERT expression. Notably, circHERC1 expression exhibits a decline with age, which correlates with reduced telomerase...
Yumeng Cui

Liver-directed AAV gene therapy in mice corrects glycogen storage disease type IX γ2

2 weeks ago
Glycogen storage disease (GSD) type IX γ2 is a rare inborn error of metabolism where a defect in glycogenolysis leads to the inability to break down glycogen in the liver. Patients with GSD IX γ2 develop hypoglycemia and advanced liver disease, placing them at risk for liver transplantation. This study evaluates the efficacy of liver-directed AAV gene therapy in a murine model of GSD IX γ2. Phkg2^(-/-) mice underwent treatment with AAV gene therapy (AAV9-LSP-mPhkg2, 5 × 10^(12) vg/kg,...
Rebecca A Gibson