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Science, Volume 392, Issue 6794, Page 183-187, April 2026.

Science, Volume 392, Issue 6794, Page 194-201, April 2026.

Science, Volume 392, Issue 6794, Page 188-193, April 2026.

Science, Volume 392, Issue 6794, Page 221-224, April 2026.

Science, Volume 392, Issue 6794, Page 178-182, April 2026.

Science, Volume 392, Issue 6794, Page 154-154, April 2026.

Science, Volume 392, Issue 6794, Page 155-155, April 2026.

Decades of observations tracked the fraying of once-friendly relations among Ugandan chimpanzees

To impede metastasis, researchers seek to develop novel treatments that disrupt tumor cell clusters

The heart’s faint magnetic signals can’t be detected at large distances, researchers say

Disruption of intestinal ecosystem could contribute to diabetes and other health issues, scientists say

Aging has long been associated with oxidative stress, yet its underlying metabolic drivers remain unclear. Liu et al. identify a conserved, iron-driven lipid peroxidation of primate aging mediated by ACSL4 and demonstrate that vitamin C directly suppresses this process, offering a translatable strategy to mitigate age-associated functional decline.

In a recent Cell Press Blue paper, Zhang et al. identify two polyunsaturated lipids that selectively eliminate senescent cells by inducing ferroptosis, uncovering this iron-dependent cell death pathway as a vulnerability for senescent cells. Their findings position ferroptosis induction as a promising strategy for targeting senescence and aging-associated diseases.

Tissue homeostasis emerges from mechanical feedback loops balanced by cell loss and proliferation, a balance that in postmitotic tissues must be maintained without compensatory proliferation. Yet how these tissues preserve mechanical homeostasis and how this challenges function in ageing remains unclear. To establish the relationship between cell density, mechanical homeostasis, and function, we induced age-mimicking cell loss in a postmitotic retinal pigment epithelium (RPE) in vitro. This...

Cytokines are essential mediators of immune functions and regulate many other biological processes, ranging from fetal development to ageing. Dysregulation of cytokine responses can substantially increase the risk of disease and so their activity requires tight control. The formation of cytokine homodimers, heterodimers and multimers has evolved as a versatile mechanism to regulate cytokine biology, in which multimerization can enable or attenuate their activity, diversify signalling outcomes...

MicroRNAs (miRNAs) regulate gene expression and can influence processes such as inflammation, metabolism, and aging. This study assessed the effects of miR-181a-5p and miR-1249-3p mimics on the transcriptome of visceral adipose tissue in middle-aged females mice. Mice received intraperitoneal injections of either miR-181a-5p, miR-1249-3p, or vehicle control, followed by transcriptomic and metabolic analyses. Both treatments significantly reduced fasting blood glucose levels and promoted...

Oocyte quality, a critical determinant of female reproductive potential, experiences a progressive decline with age, largely driven by the cumulative effects of oxidative stress and mitochondrial dysfunction. This review thoroughly synthesizes the latest evidence concerning the molecular, cellular, and environmental factors that disrupt redox homeostasis within oocytes. It particularly highlights the pivotal roles of reactive oxygen species, impaired mitochondrial metabolism, epigenetic...

Physical fitness is a key determinant of health, yet the molecular pathways linking fitness to the risk of aging-related diseases remain unclear. We examined associations between DNA methylation-based protein level estimates (EpiScores) and five fitness traits-VO(2)max, GripStrength, JumpMax, body mass index (BMI), and cognition-in a cohort of 290 mostly old individuals (mean age of 60 ± 11 years). EpiScores for 109 plasma proteins were obtained using the MethylDetectR tool and tested for...

Influenza A virus continues to pose a significant global health burden, with older individuals experiencing disproportionate morbidity and mortality. Although aging is associated with the accumulation of senescent cells, the extent to which cellular senescence contributes to influenza severity remains poorly understood. The aim of this study was to evaluate the therapeutic potential of the senolytic drug ABT-263, a B cell lymphoma-2 inhibitor, in mitigating both acute and chronic damage in an...

The molecular correlates of Alzheimer's disease (AD) are increasingly being defined by multi-omics. However, findings from different data types are often difficult to reconcile. Here, we apply a data-driven multi-omics framework integrating seven omics layers from up to 1,358 aged human brain samples from the Religious Orders Study and Rush Memory and Aging Project. We demonstrate sprawling cross-omics biological factors relating to AD phenotypes. The strongest AD-associated factor (factor 8) is...