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CRISPR-Cas–mediated heritable chromosome fusions in Arabidopsis
Science, Volume 390, Issue 6775, Page 843-848, November 2025.
An anion-binding approach to enantioselective photoredox catalysis
Science, Volume 390, Issue 6775, Page 831-836, November 2025.
Atomic layer bonding contacts in two-dimensional semiconductors
Science, Volume 390, Issue 6775, Page 813-818, November 2025.
A cross-linked molecular contact for stable operation of perovskite/silicon tandem solar cells
Science, Volume 390, Issue 6775, Page 837-842, November 2025.
Multigas adsorption with single-site cooperativity in a metal–organic framework
Science, Volume 390, Issue 6775, Page 808-812, November 2025.
Increasing the dimensionality of transistors with hydrogels
Science, Volume 390, Issue 6775, Page 824-830, November 2025.
The Moon-forming impactor Theia originated from the inner Solar System
Science, Volume 390, Issue 6775, Page 819-823, November 2025.
An ode to change
Science, Volume 390, Issue 6775, Page 792-792, November 2025.
In defense of the know-it-all
Science, Volume 390, Issue 6775, Page 793-793, November 2025.
In red states, many academic researchers feel fear–and resolve
State-level mandates prompt changes and small acts of resistance at universities
Pigeons sense Earth’s magnetic field in an entirely new way
Specialized hair cells pick electric currents induced by magnetism
Headless bodies hint at why Europe’s first farmers vanished
Wave of mass brutality accompanied the collapse of the first pan-European culture
‘This is censorship.’ Conference requires abstracts to comply with Trump anti-DEI order
NASA-funded planetary science institute previously scrubbed hundreds of records from its archive
Vision and Cognitive Difficulties From Midlife to Late Life: Findings From the National Health Interview Survey
ObjectivesTo examine whether the association between vision and cognitive difficulties varies by age group.MethodsWe analyzed pooled data from the 2021-2023 National Health Interview Survey, including 52,582 U.S. adults aged 45 and older. Vision and cognitive difficulties were based on self-reports. Logistic regression with interaction terms assessed age-related differences.ResultsVision difficulty was reported by 22.7% of respondents. It was associated with over twice the odds of cognitive...
Utilizing accelerated and delayed murine models of aging to address the "healthspan issue" - A review of skeletal muscle health
The gap between lifespan and healthspan is increasing globally, resulting in millions of individuals spending additional years burdened by frailty or disease. This disparity, paired with the increasingly aged populations of Western nations, poses a palpable predicament to public health and the economy. Deterioration of the skeletal muscle system is a key contributor to illness, loss of independence, and diminishing healthspan. Muscle quality correlates to longevity due to its significant role in...
PRDX1 promotes testosterone synthesis and attenuates aging via redox regulation of ATG4B to modulate lipophagy
Testosterone insufficiency disrupts spermatogenesis and expedites male aging. Autophagy facilitates testosterone synthesis. However, a molecular reduction mechanism of autophagy-related protein 4 homolog B (ATG4B) has not been established. Herein, we reveal that peroxiredoxin 1 (PRDX1) is clinically associated with male fertility disorders. Adult mutant mice with Leydig cell (LC)-specific deletion of the Prdx1 gene exhibit premature testicular aging and infertility. A series of in vivo and in...
Classically studied coherent structures only paint a partial picture of wall-bounded turbulence
For the last 140 years, the mechanisms of transport and dissipation of energy in a turbulent flow have not been completely understood. Previous research has focused on analyzing the so-called coherent structures, organized flow patterns characterized by their spatial coherence, lifespan and significant contribution to momentum and energy transfer. However, the connection between these structures and the flow development is still uncertain. Here, we show a data-driven methodology for objectively...
AI-driven discovery of dual antiaging and anti-AD therapeutics via PROTAC target deconvolution of a super-enhancer-regulated axis
The lack of safe, durable therapeutics that act against both biological aging and Alzheimer's disease is an unmet clinical need. To bridge this gap, we devised an artificial intelligence (AI)-enabled approach that pairs rapid compound triage with mechanistic target deconvolution. Our AI-driven screening highlighted melatonin (MLT) as a promising candidate. Serum profiling of 161 human individuals confirmed an age-related fall in circulating MLT level, while subsequent in vivo and in vitro...
AI-driven discovery of dual antiaging and anti-AD therapeutics via PROTAC target deconvolution of a super-enhancer-regulated axis
The lack of safe, durable therapeutics that act against both biological aging and Alzheimer's disease is an unmet clinical need. To bridge this gap, we devised an artificial intelligence (AI)-enabled approach that pairs rapid compound triage with mechanistic target deconvolution. Our AI-driven screening highlighted melatonin (MLT) as a promising candidate. Serum profiling of 161 human individuals confirmed an age-related fall in circulating MLT level, while subsequent in vivo and in vitro...
Inferring multi-organ genetic connections using imaging and clinical data through Mendelian randomization
Understanding the complex relationships among major clinical outcomes and the interplay among multiple organs remains a considerable challenge. By using imaging phenotypes, we can characterize the functional and structural architecture of major human organs. Mendelian randomization (MR) provides a valuable framework for uncovering robust relationships between phenotypes by leveraging genetic variants as instrumental variables. Here we conduct a systematic multi-organ MR analysis involving 402...