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Ethicists are wary of an HHS proposal to loosen rules for “low-risk research”

Scientists have discovered a stem cell that appears to serve as a master source for tendon and ligament cells throughout the body. In lumbar spinal stenosis, these cells become unusually active and may drive the ligament overgrowth that squeezes spinal nerves and causes pain, numbness, and difficulty walking. Researchers found that reducing calcium signaling stopped this abnormal growth in mice.

Fingertips of Suriname toads are hypersensitive motion detectors, new study reveals

Scientists have discovered a new tick-borne virus in China that causes flu-like illness and may account for previously unexplained cases of fever, fatigue, digestive problems, and low platelet counts. Most patients with ALTNV alone recovered, but coinfections with another dangerous tick-borne virus were linked to more serious complications.

People with diabetes reported better quality of life after days when their glucose stayed largely within a healthy range, even when levels fluctuated more than usual. The unexpected finding suggests that pursuing extremely tight glucose control may sometimes come with a hidden lifestyle burden.

A new study suggests coffee may influence mood and brain function by changing the activity of microbes in the gut. Both caffeinated and decaf coffee were linked to lower stress, depression, and impulsivity, while also producing measurable changes in gut bacteria and metabolites. Decaf was associated with better learning and memory, while caffeinated coffee appeared to reduce anxiety and improve attention.

Spaceflight may dramatically change the gut within weeks, causing bacteria to break down more protein as food moves more slowly through the intestines. The shift could help explain astronaut constipation and may have wider effects on health, making it an important concern for future missions to Mars.

A compound the body can make after eating pomegranates, walnuts, and some berries improved measures of heart function by up to 80% in animal models of a difficult-to-treat form of heart failure. Urolithin A helped stiff heart tissue relax and reduced scarring and abnormal enlargement. It also improved relaxation in engineered human heart tissue.

Interactions between nervous system and adipose tissue are involved in the regulation of adipocyte browning. However, whether microglial activation participates in the regulation of cold exposure-induced sympathetic innervation and adipocyte browning is unclear. Here, we demonstrate that RNA m6A demethylase ALKBH5 in the microglia nucleus of hypothalamus (PVH) region inhibits cold exposure-induced adipocyte browning in the subcutaneous white adipose tissue (sWAT) of male mice. The single...