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The MICOS Complex Regulates Mitochondrial Structure and Oxidative Stress During Age-Dependent Structural Deficits in the Kidney
Due to aging, the efficiency of kidney function begins to decrease. Dysfunction in mitochondria and their cristae is a hallmark of aging. Therefore, age-related decline in kidney function could be attributed to changes in mitochondrial ultrastructure, increased reactive oxygen species, and alterations in metabolism and lipid composition. We sought to understand how mitochondrial ultrastructure is altered over time in tubular kidney cells. A serial block face-scanning electron microscope and...
Implementation of a territorial geriatric hotline in Southwestern France: a monocentric observational study to improve access to geriatric expertise
CONCLUSION: A territorial geriatric hotline integrated into local professional healthcare networks is feasible and widely utilized, as reflected by the overall call volume. It facilitates rapid access to geriatric expertise and, based on the analysis of calls with complete data, may contribute to improving patient orientation, and to proposing alternatives to emergency department transfers. However, the study design did not allow for the systematic evaluation of the clinical outcomes associated...
The role of digital literacy among older adults in the continuance intention toward smart care service platforms: survey study
CONCLUSIONS: The findings indicate that if government administrators and platform developers want to implement effective SCSP development and promotion strategies, they need to pay attention to improving older adults' digital literacy, optimizing the platform's information, system, and service quality, and strengthening external publicity to enhance the platforms' social influence.