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Genetic evidence links hypertension to accelerated brain aging
Hypertension affects one-third of adults and is a major comorbidity of neurocognitive disorders. The causal relationship, shared genetic architecture, and upstream mechanisms linking hypertension to brain aging remain unclear. Hypertension GWAS datasets from MVP and FinnGen R12 were meta-analyzed as the exposure, and a European-ancestry brain age gap (BAG) GWAS derived from the UK Biobank and LIFE-Adult cohorts was used as the outcome. MR and GSMR assessed causality. LDSC, HDL, and S-LDSC...
High-velocity resistance training improves the force-velocity profile in middle-aged and older adults
The main goal of the present study was to examine the effects of a high-velocity resistance training (HVRT) program on the force-velocity (F-V) profile of different groups of aging adults. An additional aim was to explore whether individual baseline F-V profiles were associated with training-induced improvements in muscle power and functional capacity. Middle-aged and older adults with and without mobility limitations (n = 36, 61 ± 13 years) completed a 12-week HVRT program (2 days/week, 40-60%...
Personality disorders and related healthcare use among older United States veterans experiencing housing instability and homelessness, 2016-2024
Veterans are vulnerable to housing instability and/or homelessness (HUH) and may encounter unique challenges that affect their healthcare. While research has noted connections between major psychiatric disorders and HUH, few studies have examined personality disorders (PD) and their sex-specific relationships with HUH and healthcare use among aging veterans. We examined sex differences in the epidemiology of PD and their impact on healthcare service use among aging HUH veterans. A...
Beyond single-modality screening: toward an EEG-IoT dual-stream framework for early detection of mild cognitive impairment in community-dwelling older adults
No abstract
Imaging the neurohiv brain in animal models: past, present, and future-toward longitudinal, whole-brain aging phenotypes
Animal models are essential for defining mechanisms of HIV-associated brain injury in the antiretroviral therapy era, where neurocognitive impairment and brain aging have replaced opportunistic infections as dominant clinical concerns. Humanized mice, EcoHIV murine systems, and SIV or SHIV nonhuman primates now enable increasingly sophisticated brain imaging across in vivo and ex vivo scales. Structural and diffusion MRI, perfusion imaging, manganese-enhanced MRI, and multiphoton and endoscopic...
The Construct Validity of the Life-Space Assessment in the Canadian Longitudinal Study on Aging (CLSA)
CONCLUSION: The LSA can be used to differentiate between known groups. However, there is limited evidence of its convergent validity as its relationship with other measures of actual mobility, perceived mobility, and locomotor capacity for mobility was weak. Future studies need to assess the convergent validity of the LSA against different comparator measures before its use among community-dwelling Canadians.
Rocked by aid cuts, Malawi rethinks how it funds health
Services for mothers and children continue to suffer in the meantime
Daily briefing: Naked mole rat queens use a smell to stay on top
CRISPR gets a power boost from AI-designed ‘molecular scissors’
US politicians push agencies to restrict research collaboration with China
‘Explosive diarrhoea’ outbreak grips US: how researchers are hunting its source
AI is set to completely transform cybersecurity — here’s how researchers must prepare
Trained immunity links hematopoietic stem cell aging to aging-associated inflammation
Will making ‘replication studies’ easier to find help science self-correct?
A global capital for AI safety is emerging — and it’s not in Silicon Valley
Why do astronauts’ bodies waste away? Space-station study points to mitochondria
Helium escaping from the atmosphere of a nearby rocky exoplanet orbiting in a habitable zone
Science, Ahead of Print.
Preferred synthesis of armchair transition metal dichalcogenide nanotubes
Science, Ahead of Print.
De novo design of orthogonal far-red, orange, and green fluorophore-binding proteins for multiplexed imaging
Science, Ahead of Print.
A cinnamyl alcohol dehydrogenase–like scaffold organizes monoterpenoid indole alkaloid biosynthesis
Science, Ahead of Print.