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Multimorbidity Among Adults Aged 50 and Over in Europe and Israel: Prevalence and Associated Factors From SHARE Wave 9

2 weeks ago
CONCLUSIONS AND IMPLICATIONS: The high prevalence and cross-country differences highlight the complexity of multimorbidity among adults aged 50 years and older in Europe and Israel. The findings reinforce the influence of demographic, clinical, and lifestyle factors and emphasize the need for public policies promoting healthy aging and integrated health care.
Amanda Almeida Gomes Dantas

Entropy of Muscle Fiber Histology Predicts Mobility in Older Adults: The Study of Muscle, Mobility, and Aging

2 weeks ago
Entropy may play an underappreciated role in human aging, such as in skeletal muscle functional declines. Histologically, muscle appears increasingly disorganized with aging, with greater fiber size variability and fiber-type grouping. We tested the hypothesis that entropy is associated with reduced physical performance and muscle function, independent of muscle mass. We quantified a homeostatic dysregulation index of muscle (HDI(M)) as a proxy for entropy of muscle fiber disorganization based...
Namki Hong

Ageing Through the Looking-Glass: The Different Flavours of Clonal Haematopoiesis

2 weeks ago
Clonal haematopoiesis (CH) is the presence of acquired mutations in blood cells and is a consequence of ageing that is linked to malignancy, cardiovascular disease and other diseases of ageing. CH is a reflection of genomic instability with ageing; however, there is evidence that CH may exacerbate features of normal ageing, including inflammageing and immunosenescence, and more directly contribute to disease causation. CH can manifest as mosaic loss of X or Y, autosomal mosaic chromosomal...
Jasmine Singh

Adaptive deep brain stimulation in Parkinson's disease

2 weeks 1 day ago
With the introduction of adaptive deep brain stimulation (aDBS) for Parkinson's disease, new questions emerge regarding who, why, and how to treat. This paper outlines the pathophysiological rationale for aDBS, which provides real-time modulation of the stimulation amplitude based on subthalamic beta (range 13-30 Hz) activity and related physiomarkers. We review clinical evidence comparing aDBS with conventional DBS in terms of motor improvement, side-effect reduction, energy efficiency, and...
Martijn G J de Neeling

Age-related sarcopenia and the gut microbiome: mechanistic insights into the gut-muscle axis and potential microbiome based therapeutic interventions

2 weeks 1 day ago
Ageing is associated with a loss of skeletal muscle mass, strength and function, termed sarcopenia. The presence of sarcopenia is known to be problematic leading to an increased risk of falls, fractures and mortality. Age-related changes in the gut microbiome, characterized by reduced diversity and altered metabolite production, may compromise intestinal barrier function, leading to increased permeability. These age-associated changes in the gut microbiome led to changes in circulating microbial...
Sophie L Allen

Carbon-halogen bond substitution enables high-utilization four-electron iodine redox in noncorrosive dilute electrolytes

2 weeks 1 day ago
Aqueous Zn | |I(2) batteries, involving I^(-)/I⁰/I^(+) redox, are promising yet usually facing low I(2) utilization dominated by I⁰/I^(+) redox, especially under high loadings. Unlocking alternative pathway to I⁰/I^(+) redox, preferably in noncorrosive dilute electrolytes, is a crucial solution. Here, we report a pathway towards more thermodynamically favorable I⁰/I^(+) redox, via a unique carbon-halogen bond substitution. This pathway is realized with a low-concentrated (0.7 M), noncorrosive...
Zhiheng Shi

Whole blood transcriptional signatures of age and survival identified in long life family and integrative longevity omics studies

2 weeks 1 day ago
Although aging is a universal event, some individuals are able to achieve extreme longevity. The Long-Life Family Study (LLFS) enrolls participants from families enriched with long-lived individuals, serves as a valuable dataset for studying ageing phenotypes and identify potential intervention targets. We analyzed the association between age at blood draw and 16,284 RNAseq-based blood transcriptomic data from 2,167 LLFS participants with ages ranging from 18 to 107, replicated the results in...
Mengze Li

Gerontology lost in translation from demography to biology of aging and back

2 weeks 1 day ago
Changes in human survival and mortality patterns resulting in life expectancy (LE) increase are profoundly significant for society and critically depend on societal factors but cannot escape frames defined by biology. Demography, a social discipline, uses descriptive terms, such as survival curve rectangularization, mortality compression, lifespan disparity reduction, and mean (modal, median) lifespan increase, to define the beneficial changes thought possible due to deceleration of aging. The...
A Golubev

Acceleration of Lactate Uptake and Utilization Contributes to Neuroprotective Action of FGF21 Involved in Naturally Aging Mice

2 weeks 1 day ago
Brain aging is characterized by neuroinflammation and lactate metabolic changes. However, the functional role of FGF21 in the aging brain and its influence on lactate homeostasis remains unclear until now. In the study, male C57BL/6 mice were divided into 2-month-old (control), 20-month (aging), and FGF21-treated aging mice (FGF21). We also examined the MAPK signals and astrocyte-neuron lactate shuttle (ANLS) proteins in wild-type and hydroxycarboxylic acid receptor 1-knockout (HCA1-KO) mice...
Keru Ji