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Self-assembled monolayers with cross-linkable header on the linker for durable perovskite photovoltaics
Perovskite solar cells (PSCs) using self-assembled monolayers (SAMs) as hole transporting materials have achieved impressive efficiencies. However, the vulnerability of SAMs causes desorption under light and thermal stress. While various modifications to the conjugated core and anchoring group of SAMs have been explored, challenges in balancing efficiency and stability remain. Here, we introduce a new class of cross-linkable SAMs, uniquely functionalized at the molecular linker. Upon in situ...
Dendritic translation and neuroproteasome-mediated degradation of endogenous tau revealed by STARFISH
In Alzheimer's disease, the protein tau is thought to redistribute from axons to the somatodendritic compartment and form fibrillar aggregates. Although tau aggregation is a hallmark of Alzheimer's disease, the dynamics of its synthesis and degradation are not well characterized. Given that nascent polypeptides are particularly susceptible to misfolding, local control of tau synthesis and degradation may be essential to prevent aggregation. Here we develop STARFISH, a method for visualizing the...
Lactiplantibacillus plantarum AS21 Attenuates Sex-Biased Glucose Intolerance in Aging Mice via Gut Mucosal Microbiota-Derived Citrulline
Aging-related metabolic decline, particularly impaired glucose tolerance, represents a growing challenge in aging populations. Probiotics are promising modulators of host metabolism; however, how sex differences influence their efficacy in mitigating metabolic aging remains poorly understood. Here, we administered Lactiplantibacillus plantarum AS21 to naturally aged male and female mice for 6 months. We observed a pronounced sexual dimorphism in metabolic decline, with aged males exhibiting more...
How storey configuration and number of transition points shape opportunities for outdoor access in residential care facilities: implications for age-friendly environments
CONCLUSIONS: Storey configuration and number of transition points constitute structural conditions that shape outdoor access in RCFs. These findings have implications for age-friendly design and planning of RCFs as well as for person-centred care and rehabilitation.
An expanding role for ATG8s and ATG8 E3-like ligases in maintaining membrane integrity
Endolysosomal membranes are frequently damaged by pathogenic stress associated with aging, infection, and neurodegeneration, and failure to repair such damage leads to inflammation and cell death. Recent advances identify membrane ATG8 conjugation (atg8ylation) as a key process that links damage detection to coordinated lysosomal repair, removal, and regeneration. Beyond its canonical role in macroautophagy, membrane atg8ylation also occurs on preexisting, non-autophagosomal single membranes...
Comparison of Claims-Based Algorithms for Dementia Identification: A Cross-Sectional Analysis of the National Health and Aging Trends Study (NHATS)
CONCLUSION: Commonly used claims-based algorithms to identify ADRD had reasonable validity, though each presented important context-dependent tradeoffs and none was uniformly superior. These findings highlight the importance of accurately diagnosing ADRD in clinical settings and of understanding each algorithm's strengths and limitations based on the use case. Limitations include that NHATS is not a "gold standard" for comparison of claims-based algorithms and we only analyzed NHATS respondents...
Surprising uniqueness of Puerto Rico’s trees could make them more resistant to drought
Two trees from the same species can vary in how they transport and manage water, improving specieswide drought resilience
Daily briefing: Ancient rise in CO<sub>2</sub> hints at what could happen today
Briefing Chat: Anthropic rolls out new AI watermark — will it make a difference?
Author Correction: Cell intrinsic immunity spreads to bystander cells via the intercellular transfer of cGAMP
Physical activity delays ovarian aging in part through adiponectin-related signaling pathways
Exercise slows ovarian aging
Undocumented migration does not raise crime rates, huge study finds
Einstein the musician, AI prophets and more: Books in brief
Publisher Correction: Targeting cancer-specific mutations with RNA-triggered chromatin shredding
NIH is ending a key grant for budding clinical researchers
Agency will no longer allow K career awards to fund clinical trials
Slavery linked to mortality gap between Black and white Americans today
New study is among the first to quantify and explain slavery’s influence in contemporary U.S. health disparities
This common vitamin deficiency becomes far more dangerous when paired with belly fat
A large study of more than 5,500 adults over 50 found a striking combination of risk factors: abdominal obesity paired with vitamin D deficiency was linked to a 123% higher risk of death over six years. Each condition was associated with increased risk on its own, but together they appeared to create a dangerous feedback loop, with belly fat reducing the amount of vitamin D available in the bloodstream while low vitamin D may worsen inflammation and other health problems.
Drought may have driven Brazil’s first yellow fever outbreak in nearly 80 years
Dry conditions forced forest-dwelling primates into the cities, bringing with them mosquitoes—and disease
Budget cuts and delays leave hundreds of Argentine postdocs in limbo
Many scientists are scrambling to make ends meet and reconsidering their future in research