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‘Memory foam’ skeleton in cells helps them to navigate
Alzheimer’s decline slows with just a few thousand steps a day
How to fight climate change without the US: a guide to global action
From pangolins to primates: how I use zoo facilities to treat wild animals
Accelerating the discovery of multicatalytic cooperativity
Independent mechanisms of inflammation and myeloid bias in VEXAS syndrome
A versatile cohesion manipulation system probes female reproductive age-related egg aneuploidy
‘Biotech Barbie’ says the time has come to consider CRISPR babies. Do scientists agree?
Insiders warn how dismantling federal agencies could put science at risk
PhD training needs a reboot in an AI world
Sex, drugs and the conscious brain: Francis Crick beyond the double helix
Letters to scientific journals surge as ‘prolific debutante’ authors likely use AI
New study reinforces worries about “mass production of junk” by unscrupulous scholars aiming to pad their CVs
Oligo fucoidan alleviates sarcopenia via attenuating muscle mass loss and function decline in senescence-accelerated mouse prone 8 mice
CONCLUSION: Our findings show that OliFuco is a promising nutritional intervention for mitigating sarcopenia by preserving muscle mass and function in aging populations, offering a novel strategy to address age-related muscle decline.
Contradictory dual role of antinutrients in nutrient inhibition and anti-aging: A comprehensive review on health benefits, processing techniques, and dietary strategies
BACKGROUND: Antinutritional factors (antinutrients) are bioactive compounds in plant-derived foods that can impair nutrient absorption and reduce the bioavailability of proteins, carbohydrates, and essential minerals. Major representatives include phytates, oxalates, lectins, tannins, saponins, and enzyme inhibitors, which have been associated with adverse nutritional outcomes through interference with nutrient uptake.
Digital intelligence for cardiometabolic health management in older adults: protocol for a community-based prospective cohort study
BACKGROUND: Cardiovascular diseases (CVDs) represent a significant cause of morbidity and mortality among older adults in China, exerting a substantial influence on their quality of life and life expectancy. The country’s ageing population is predicted to intensify this burden, underscoring the need for the development of innovative and effective management strategies.
G-protein-coupled receptor ADGRG1 drives a protective microglial state in Alzheimer's disease through MYC activation
No abstract
Tangles and Plaques: A deep dive into the pathological hallmarks of Alzheimer's disease
Alzheimer's disease (AD) is the most prevalent neurodegenerative disorder. In AD, there is a gradual impairment of memory and cognitive function that interferes with daily living. The pathophysiology of AD revolves around complex interactions between amyloid-β (Aβ) overproduction and accumulation, followed by tau hyperphosphorylation, which together promote a cascade of neuronal dysfunction and degeneration. AD has two forms, sporadic and familial, with genetic variants such as triggering...
Intrinsic changes in cell differentiation and identity drive impaired wound healing in aged female murine skin
Cellular and molecular mechanisms that drive a perturbed wound microenvironment and impaired healing in aged skin have not been fully delineated. To obtain a comprehensive understanding of cell-intrinsic changes acquired during ageing that impact early responses to injury, we performed single-cell RNA sequencing in young and aged intact female murine skin and wounds 3 days post-injury. We observed that substantial changes in the mean proportional distribution and transcriptomic state of skin...
Functional disability screening in the elderly: a machine learning approach with ELSI-Brazil data
The aim of this study was to investigate, validate and apply Machine Learning (ML) algorithms to predict functional disability in elderly individuals using data from ELSI-Brazil. Furthermore, it sought to map the performance of the models and identify key multidimensional variables-encompassing sociodemographic and economic aspects, health status, behaviors, mental health and access to services-that could serve as early risk indicators and, based on the selected model, understand which...
Dystrophin and dystrophin association protein expression decreases with age in vascular smooth muscle
As humans age, the aorta stiffens, diminishing its essential shock absorber function. This increased stiffness transmits higher pressures to downstream vessels in the kidney, brain, and heart, contributing to hypertension and end-organ damage. Although multiple mechanisms involving extracellular matrix (ECM) remodeling and vascular smooth muscle cell (VSMC) contributions to aortic stiffness have been described, additional molecular players likely remain uncharacterized. Dystrophin (DYS) and the...