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A critical developmental process affecting aging and age-associated disease, cell senescence is characterized by persistent growth arrest and adaptive gene expression patterns. A common RNA modification, N6-methyladenosine (m⁶A), regulates gene expression profiles but its impact on senescence has not been studied globally. Here, we elucidated the m⁶A landscape in proliferating and senescent human fibroblasts using epitranscriptomic microarray and m⁶A-crosslinking and immunoprecipitation followed...

Agency is bringing back a version of a funding limit that was quickly abandoned nearly a decade ago

Facing economic and regulatory pressures, Inotiv says it is seeking ways to continue operations

A major long-term study of more than 54,000 adults found that where nitrate comes from may matter far more than how much you consume. People who got more nitrate from vegetables—roughly the amount in a cup of baby spinach a day—had a lower risk of developing dementia, while higher nitrate and nitrite intake from red meat, processed meat, and even drinking water was linked to a greater risk.

A trio of major studies found that finerenone may protect the kidneys and heart in far more people than previously thought. The drug significantly slowed kidney disease progression and reduced the risks of kidney failure, heart failure, cardiovascular death, and overall mortality. Researchers saw benefits not only in patients with diabetes but also in those with non-diabetic kidney disease, a group with limited treatment options.

Shrunken forelimbs were likely a byproduct of large, powerful skulls—with one notable exception

Scientists may have a better way to make gene-edited babies, but it’s still far from safe

Lysosomal defects are closely linked to Parkinson's disease (PD). Mutations in the GBA1 gene, encoding the lysosomal enzyme glucocerebrosidase (GCase), are major genetic risk factors for PD. GBA1 deficiency causes lysosomal dysfunction, leading to α-synuclein (α-syn) accumulation and PD progression. However, the underlying mechanisms remain unclear. In this study, we identified a novel GBA1-KAT8 regulatory pathway that controls lysosomal activity. GBA1 overexpression enhances lysosomal enzyme...

Graphic depiction of the narrative creation and student attitude changes.