Aggregator

CONCLUSION: The findings indicate a high burden of self-reported chronic health problems and functional dependency among older adults in a hilly municipality of Nepal. Marital status, smoking, and physical activity were significantly associated with chronic illness, while age and chronic illness were significantly associated with ADL dependency. These results highlight the need for community-based geriatric screening and targeted behavioural interventions to improve health status among older...

CONCLUSIONS: Elderly patients with multimorbidity who underwent elective surgeries have high aging self‑stereotype scores, which are independently associated with first‑time surgery, multimorbidity burden, and decision‑making preference. A management model that combines multidisciplinary collaboration with family support should be established to reduce negative stereotypes and improve quality of life among these patients.

CONCLUSIONS: The findings suggest that the psychological consequences of LTCI exposure may be more visible in the upper tail of the depression distribution among older adults with high care needs than in average mental-health indicators, with the signal appearing stronger in women in exploratory analyses. Policy evaluation should therefore move beyond mean-based indicators and strengthen needs-matched, psychologically supportive long-term care for vulnerable older adults.

CONCLUSIONS: In this cross-sectional study in China, exposure to depressive symptoms was associated with IADL disability. This association was modified by age, sex, and outdoor activity engagement. These findings indicate a need to prevent depressive symptoms and a need for an intervention strategy for mental health to reduce the potential risk of IADL disability. Moreover, emphasizing personalized interventions that target individuals with depressive symptoms exposure may minimize the burden of...

Aging is a multifactorial process driven by interconnected hallmarks, including chronic inflammation, mitochondrial dysfunction, genomic and epigenetic alterations, and dysregulated intercellular communication. Extracellular vesicles (EVs), naturally derived nanoscale membrane vesicles capable of transporting diverse bioactive cargoes across tissues and biological barriers, have emerged as a highly promising platform for regenerative and anti-aging therapeutics. In this review, we systematically...

Analysis of more than two dozen new genomes suggests our closest cousins remained genetically healthy, just before they vanished