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INTRODUCTION: Aging is associated with alterations in white matter structure and decline in bimanual performance. These parallel changes may be interrelated, as previous studies have linked cerebral white matter properties to both motor and cognitive function. The cerebellum plays a central role in complex motor coordination and higher-order processes, yet age-related differences in cortico-cerebellar pathways remain insufficiently understood. This study therefore examined two major...

CONCLUSIONS: This study contributes to ageing research by examining sustained robustness, rather than frailty progression alone, as a longitudinal outcome in a large multinational cohort. By identifying behavioral, psychosocial, and functional characteristics associated with sustained robustness, the study frames robustness as a measurable longitudinal outcome in ageing research and practice. These findings support a more balanced and positive conceptualization of ageing - one that emphasizes...

CONCLUSIONS: Frailty is an important risk factor for limitations in the ability to live independently, with a particularly high burden observed in the Baltic countries. Despite weaker associations with new limitations compared with the Nordic countries, the higher prevalence of frailty, poorer health profiles, and lower levels of physical activity in the Baltic countries highlight a substantial need for early identification and targeted prevention.

Regenerative capacity varies widely across animals, yet aging is often accompanied by declining tissue homeostasis and regenerative potential. In many species, regeneration of complex structures relies on epimorphic programs that form a blastema, coordinating cell proliferation and pattern reorganization after injury. Although aging-associated regeneration defects have been documented in several bilaterian models, how aging shapes regeneration in early-branching metazoans with robust...

Aging exacerbates the incidence of discogenic chronic low back pain by excessive inflammation and immune cell presence. Aging reduces intervertebral disc (IVD) Wnt signaling, which is associated with IVD cell differentiation, IVD cell proliferation and anti-inflammatory signaling. However, it is unclear how in vivo Wnt signaling-absent IVD cells, which model aged IVD cells, regulate chemotactic signaling and immune cell recruitment. We hypothesized that Wnt signaling-absent IVD cells attenuate...

Ageing biomarkers quantify molecular, physiological or functional features that vary between individuals as they age and may improve prediction of health outcomes beyond chronological age. Recently, plasma proteomics have been used to estimate the biological ages of 11 human organs. Although accelerated organ ageing is associated with higher mortality risk, systematic benchmarking against established ageing biomarkers is lacking. Here, we pursued two complementary aims. First, we benchmarked...

Strength training may be one of the most powerful tools for staying independent as you age. Age related muscle loss, known as sarcopenia, can make everyday tasks harder while increasing the risk of falls, fractures, and loss of mobility. Research shows that resistance exercises such as squats, weights, resistance bands, and even body weight movements can preserve or rebuild strength, and surprisingly, even one session a week can produce meaningful benefits.

Major discoveries, including the role of DNA, the biological basis of psychology, and the human genome, missed out on science’s top recognition

Scientists welcome new money but remain cautious about weakening environmental protections

To get to the bottom of this perplexing behavior, Science interviewed the agent