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Ancient mass grave in Serbia seen as a grisly show of power
Women and children were executed in an elaborate prehistoric ritual
Whoa! When horses whinny, they whistle and sing at the same time
New anatomical research reveals the one trick all ponies know
Molecular Mechanisms of RNA Polymerase I Transcription in Health and Disease: An Overview
RNA polymerase I (Pol I) is a specialized eukaryotic enzyme responsible for transcribing ribosomal DNA into precursor rRNA, a process that initiates ribosome biogenesis and supports cellular growth, metabolism, and proliferation. Recent structural and mechanistic studies have revealed unique features of Pol I architecture that enable high transcriptional output and tight regulatory control. Pol I activity is dynamically regulated by signaling pathways, epigenetic mechanisms, and chromatin...
Integrated analysis of load-velocity profiles, muscle ultrasound measures, and lifestyle determinants in older adults with and without fall history
Falls in older adults result from declines in muscle quality. This study aimed to examine differences in load-velocity profile (LVP) metrics, muscle ultrasound measures, strength, functional tests, and lifestyle between older adults with and without falls, and to analyze their association with sit-to-stand power. Sixty-two older adults (41 non-fallers, 21 fallers; mean age 68.32 ± 5.07 years) underwent three lab sessions. LVP was determined via functional electromechanical dynamometry during a...
Sleep disturbances and Alzheimer's disease: a multiscale approach from exposome to neurobiology and precision medicine
Sleep disturbances and Alzheimer's disease (AD) are interconnected public health challenges. However, the underlying mechanisms of their complex relationships remain elusive. Here, we propose a hypothetical integrative, stream-like model outlining how external and internal exposome factors accelerate brain aging, thereby exacerbating circadian dysregulation, orexin-mediated hyperexcitability, metabolic imbalance, and inflammaging. These changes can lead to increased sleep fragmentation and...
Aging-associated autoimmunity in genetically diverse UM-HET3 mice shows an early female sex bias
Sjögren's disease, an autoimmune disorder characterized by the presence of circulating autoantibodies and lymphocytic infiltrates in salivary glands, predominantly affects women later in life. By leveraging genetically heterogeneous UM-HET3 mice, this study tested the hypothesis that female sex and aging interact to shape susceptibility to autoimmunity and salivary gland inflammation. Female and male UM-HET3 mice were evaluated across the adult lifespan for the development of glandular...
Daily briefing: New AI drug-discovery engine is ‘on the scale of an AlphaFold4’
Whistle while you whinny: researchers identify two sounds straight from the horse’s mouth
First-of-a-kind stem-cell therapies set for approval in Japan
Iron Age mass grave reveals unprecedented violence against women and children
Markovnikov hydroamination of terminal alkenes via phosphine redox catalysis
Attenuating age-related decline in dendritic cell migration improves vaccine efficacy via gut-immune crosstalk
Music is not a universal language — but it can bring us together when words fail
How big is the ‘motherhood penalty’? In Denmark, it adds up to $120,000
This AI can improve your peer review — and make it more polite
Historically Black US universities chase top research ranking
AI tools can design genomes. Will they upend how life evolves?
Why every scientist needs a librarian
From Victorian voyages to vanishing maps: Books in brief
Ancient artifacts hint at earliest protowriting
Geometric shapes on 40,000-year-old bone and ivory suggest early European Homo sapiens long possessed cognitive tools for language