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Higher carbon storage in primary than secondary boreal forests in Sweden

1 week 6 days ago
Science, Volume 391, Issue 6791, Page 1256-1261, March 2026.
Didac Pascual, Gustaf Hugelius, Josep G. Canadell, Jennifer Harden, Robert B. Jackson, Katerina Georgiou, Anders Jonshagen, Johan Lindström, Karl Ljung, Emily Register, Camille Volle, Johanna Asch, Ulrika Ervander, Geerte Fälthammar De Jong, Jia Sun,…

Blood-brain barrier-penetrative lipid nanoparticles enable systemic delivery of TRIM11 mRNA to disaggregate Tau in Alzheimer's disease models

2 weeks ago
Hyperphosphorylated Tau aggregates are a central pathological hallmark of Alzheimer's disease (AD), yet no approved therapy directly targets this process. mRNA therapeutics provide a transient and non-viral option but are limited by the blood-brain barrier (BBB). TRIM11 is an ATP-independent disaggregase that dissolves pathological Tau fibrils and promotes proteasomal clearance. Here, a ligand-free lipid nanoparticle (PLNP) is developed with zwitterionic, acetylcholine-mimetic...
Yan Zou

TET CpG sequence-context-specific DNA demethylation shapes progression of IDH-mutant gliomas

2 weeks ago
Treatment decisions in IDH-mutant oligodendrogliomas are shaped by tumor aggressiveness, underscoring the need for objective grading of these malignant brain tumors. We collect 302 primary and recurrent resections from oligodendrogliomas and perform Ki-67 staining, proteomics, and DNA methylation profiling. During tumor progression, DNA methylation of oligodendrogliomas changes along a continuum. This continuum is linked to increased epigenetic aging, methylation of transcription factors and...
Youri Hoogstrate

The aging cornea: From mechanisms to clinical applications

2 weeks ago
Aging is a multifactorial process characterized by a gradual decline in function, increased susceptibility to diseases, and diminished regenerative capacity. As the primary refractive structure and barrier of the eye, the cornea undergoes significant structural and functional changes during aging, making individuals more prone to various ocular surface diseases. Key age-related corneal changes include epithelial thinning, stromal remodeling with increased collagen cross-linking, endothelial cell...
Xueer Zheng