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Rethink how we build AI to enable effective climate-change mitigation
NASA’s Mars Sample Return mission is dead
Congress backs Trump administration’s efforts to kill project that would ferry martian rocks to Earth
Fresh conflicts erupt around giant database for flu and COVID-19 sequences
Critics say “autocratic” behavior by GISAID could hamper response to a future pandemic
Appeals court agrees that NIH cannot reduce overhead payments to academic institutions
Judges uphold injunction by lower court against a 15% flat rate for indirect costs
Exclusive: Have scientists found Leonardo da Vinci’s DNA?
Inside the decadeslong quest to reveal the genes of a genius—and revolutionize art authentication
Against all odds, a curious sea creature survived the dino-killing asteroid
Coil-shelled mollusks called ammonites staved off extinction for thousands of years
Deep-sea earthquakes fuel huge plankton blooms in Antarctica
Hydrothermal vents spurred by seismic activity feed vital nutrients to Antarctic microbes
Retraction Note: Mapping NAD(+) metabolism in the brain of ageing Wistar rats: potential targets for influencing brain senescence
No abstract
Psycho-socio-economic factors and risk of cardiorenal multimorbidity in middle to older-aged adults: prospective findings from the Canadian longitudinal study on aging
Psycho-socio-economic factors (PSEFs) such as income and homeownership may influence the prevalence of cardiorenal multimorbidity (CRM), yet their prospective associations with CRM risk remain unclear. This study aimed to estimate CRM incidence and examine its relationships with multiple PSEFs in a nationally representative Canadian cohort. We analyzed data from 16,557 participants (mean age: 60.4 years; 48.9% men) in the Canadian Longitudinal Study on Aging (CLSA) who were free of CRM at...
Daily briefing: The human cells in our bodies that aren’t genetically ours
Author Correction: Effect of the mitophagy inducer urolithin A on age-related immune decline: a randomized, placebo-controlled trial
Pandemic PhDs: graduates anxious, but optimistic, about the future
These women helped to shape quantum mechanics — it’s time to recognize them
Sunyaev–Zeldovich detection of hot intracluster gas at redshift 4.3
I see Mozambique’s baboons as windows into hominid evolution
Brain neuron-derived WDFY1 induces bone loss
Congress set to reject Trump’s major budget cuts to NSF, NASA, and energy science
Appropriators agree instead to keep this year’s spending nearly level
Genome-wide CRISPR screen identifies neddylation as a regulator of neuronal aging and AD neurodegeneration
No abstract
Does the concentration of public resources lead to health inequality? - a study on the impact of urban administrative hierarchy on the subjective physical and mental health of older adults
CONCLUSION: The study highlights the inequalities in the subjective physical and mental health of older adults across cities with different administrative hierarchies in China. By providing more resources, cities with higher administrative hierarchies can significantly improve older adults' life quality and subjective health. Meanwhile, marketization further strengthens the positive impact of urban administrative hierarchy on mental health. By introducing the urban administrative hierarchy as a...
The expanding roles of homologous recombination proteins in genome stability
Homologous recombination (HR) is traditionally portrayed as a DNA double-strand break repair pathway. However, emerging evidence positions RAD51, its partners BRCA1, BRCA2, and other HR factors at the core of a broader genome-maintenance network that operates by a "prevent and protect" strategy extending beyond repair. Here, we review how RAD51 can shield DNA from nucleolytic processing mediated by MRE11 and related nucleases, promote fork reversal, suppress replicative DNA gaps accumulation,...