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Senescent cells accumulate with age following stress-induced cell cycle arrest triggered by DNA damage, oncogene activation, and replicative exhaustion. While they contribute to tissue repair and tumor suppression, their persistent senescence-associated secretory phenotypes (SASPs) drive age-related diseases. The heterogeneity of senescent cell populations, particularly the distinction between primary and secondary senescence, remains incompletely understood at single-cell resolution. Here, we...

Ribosomes consist of approximately 80 distinct ribosomal proteins and rRNA. The genes encoding these ribosomal components are among the most highly expressed in growing cells. Changes in ribosome composition, such as those induced by oxidative stress, may compromise ribosome function. Such ribosomes are subsequently targeted for degradation. Additionally, under stress, both protein synthesis and ribosome biogenesis are downregulated. Under starvation stress, excess ribosomes are degraded through...

Improving cognitively healthy survival is important for achieving healthy aging. Therefore, it would be valuable to estimate the future risk of either incident dementia or death in community-dwelling older adults. This study aimed to develop a set of risk prediction models for either incident dementia or death that can be applied according to data availability across diverse clinical settings, using longitudinal data from community-dwelling older Japanese adults. A total of 8,334 participants...

Geroscience needs biomarkers that capture the progressive decline of integrated biological systems with age. Physical capacity, a direct manifestation of systemic integrity, is a core pillar of biological aging but is typically assessed through discrete clinical tests. Speech production, a complex motor act requiring coordinated respiratory, laryngeal, and articulatory control, shares fundamental physiological pathways with global physical function and may therefore serve as an accessible...

Scientists in South Korea have discovered that a probiotic bacterium found in kimchi may help the body flush out tiny plastic particles before they can build up in organs. In lab tests, the kimchi-derived microbe clung tightly to nanoplastics even under conditions designed to mimic the human intestine, where other bacteria quickly lost their grip.

A new study suggests humans became overwhelmingly right-handed because of two major evolutionary shifts: walking on two legs and developing much larger brains. Researchers found that as human ancestors evolved, their right-hand preference steadily intensified — transforming a mild tendency into one of humanity’s most distinctive traits.

Los esfuerzos de Alejandro Arteaga por identificar y proteger reptiles y anfibios tropicales lo han envuelto en controversia

Testing, sequencing, and clinical trial efforts spring to life as Bundibugyo virus spreads