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AhR inhibition promotes axon regeneration via a stress–growth switch
Expansion of outer cortical CUX2 neurons requires adaptations for DNA repair
Evidence of the pair-instability gap from black-hole masses
Electric dipole moment drives the dynamics of the TNFR1 complex I signalosome
Moiré engineering of Cooper-pair density modulation states
A µ-opioid receptor superagonist analgesic with minimal adverse effects
Dopaminergic mechanisms of dynamical social specialization
Developmental organization of sensory and sympathetic ganglia
Gene regulatory landscape dissected by single-cell four-omics sequencing
The 1000 Chinese Pangenome empowers medical and population genetics
Entanglement and electronic coherence in attosecond molecular photoionization
DNA damage burden causes selective CUX2 neuron loss in neuroinflammation
These advanced solar cells have an antique source: old bullets
These scientists chased a jet to learn more about ‘lean-burn’ contrails
Structural modifications in strain-engineered bilayer nickelate thin films
100 years of synthetic fuels
Trippy tobacco? Plants engineered to make five psychedelics at once
Approach could enable production of new medications for depression, anxiety, and post-traumatic stress
Alzheimer's disease pathology degrades an NMDA receptor-dependent spontaneous activity pattern in cortico-hippocampal circuits
Memory-based cognition relies on the integrity of cortico-hippocampal circuits, which are compromised in Alzheimer's disease (AD) as β-amyloid (Aβ) and tau accumulate. However, the mechanisms linking this pathology to circuit dysfunction remain unclear. In mouse models, using in vivo two-photon and Neuropixels recordings, we show that Aβ-tau pathology promotes both region- and layer-specific impairments, involving reduced burst firing in superficial cortical layers and CA1 and reduced mean...
GLP-1 receptor agonist fails to halt Alzheimer's disease
No abstract
Large-scale CSF and plasma proteomics reveal immune, synaptic, and extracellular matrix disruptions across neurodegenerative diseases
Neurodegenerative diseases (NDs), including Alzheimer's disease (AD), Parkinson's disease (PD), dementia with Lewy bodies (DLB), and frontotemporal dementia (FTD), share overlapping clinical and pathological features. We analyzed cerebrospinal fluid (CSF) and plasma proteomes from 2,705 and 3,009 samples, respectively, across these NDs, identifying disease-specific and shared molecular signatures. CSF showed more disease-associated proteins than plasma, with AD and DLB exhibiting the strongest...