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A simple at-home test could cut colorectal cancer death risk by 43%
People who participated in colorectal cancer screening had a 43% lower risk of dying from the disease, according to long-term data from more than 376,000 people in Sweden. The findings suggest that completing a simple at-home screening test could make a major difference in survival.
Daily briefing: Personalized mRNA vaccine shows promise for cancer
Earth-shaking thunder probes underground geology
Sleuth identifies dozens of studies that used the wrong antibody
Why we must stop talking about artificial general intelligence — and instead build ‘pro-worker’ AI
Briefing Chat: New narcolepsy drug could unlock host of novel brain therapies
Neurologist with MAHA ties to lead NIH’s child health institute
Appointment of John Gaitanis increases concern that scientific qualifications are no longer driving leadership picks
Deadly tick-borne virus gains ground in Europe as climate warms
Kosovo shows how surveillance can uncover hidden circulation—and help countries prepare before human cases appear
Scientists discover how gut bacteria “train” the intestine to fight inflammation
A compound made when gut bacteria break down dietary fiber may do more than briefly calm inflammation—it could leave a lasting protective “memory” in the gut. Northwestern Medicine researchers found that butyrate can reprogram intestinal lining cells so they continue encouraging anti-inflammatory immune responses even after the compound is gone. In mice, this effect boosted production of the immune-calming molecule IL-10 and reduced the severity of colitis-like disease.
Ozempic does something unexpected to the brain’s hunger neurons
Ozempic may work in the brain in almost the opposite way scientists expected, activating hunger-linked neurons that appear essential for sustaining fat loss. The surprising discovery in mice could reveal new targets for developing even more effective obesity drugs.
Footprints may reveal biggest known mammal from age of the dinosaurs
Beefy tracks point to a Cretaceous critter as big as a large dog or mountain lion
Knee osteoarthritis isn’t inevitable — here’s what you can do
Knee osteoarthritis can seriously affect mobility and quality of life, but its progression isn’t completely out of your control. Exercise, stronger leg muscles, a healthier diet, and even modest weight loss can dramatically reduce stress on the knees and help keep pain in check.
Schizophrenia’s lost brain connections follow a surprising pattern
Specialized brain scans reveal that schizophrenia is linked to widespread loss of the synapses that connect brain cells, with the left side of the brain hit especially hard. The damage follows a surprisingly organized pattern tied to the brain’s chemistry and wiring. Researchers also identified a left frontal region that may serve as a starting point for the loss.
Scientific spat erupts over claim that bones have key immune vessels
Discovery of lymphatic tubes suggested new possibilities for bone healing, but challenge has prompted dueling papers and publication delay in prominent journal
NASA abandons orbit-boosting rescue mission for space observatory
Novel rescue craft unable to connect with doomed Swift Observatory
The hallmarks of skeletal muscle health
Skeletal muscle is a central determinant of organismal health. Preserving muscle quality is therefore critical for preventing disease and sustaining quality of life across the lifespan. Despite its central role, the field lacks a unifying framework that defines the core properties of skeletal muscle health. Here, we propose a conceptual framework for muscle homeostasis built around seven interconnected hallmarks-metabolism and bioenergetics, proteostasis, genomics, excitability, structure,...
Inhibiting cyclin D1-CDK6 suppresses senescence-associated inflammatory gene expression and age-related functional decline
Cellular senescence contributes to aging and age-related diseases by driving chronic inflammation through the senescence-associated secretory phenotype (SASP), including interferon-stimulated genes (ISGs). Here we confirm and extend previous observations that cyclin D1 (CCND1), a key cell cycle regulator, is paradoxically upregulated across models of nonproliferating senescent cells. We show that CCND1 and its kinase partner CDK6 drive SASP and ISG expression in senescent cells by promoting DNA...
Turning CDK4/6 inhibitors against the dark side of senescence
No abstract
STINGing the brain: S-nitrosylation drives neuroinflammation in Alzheimer's disease
Neuroinflammation is a major secondary driver of Alzheimer's disease (AD). In this issue of Cell Chemical Biology, Carnevale et al.¹ demonstrate that S-nitrosylation of the cyclic GMP-AMP synthase (cGAS) stimulator of interferon genes (STING) pathway sustains pathological neuroinflammation in AD, identifying a promising therapeutic target for this devastating disease.
Risk of transmission of amyloid β pathology via transfused blood products
Seeded protein misfolding and aggregation are relevant to many neurodegenerative diseases. The archetype are prions: protein-only infectious agents that cause fatal neurodegenerative diseases including Creutzfeldt-Jakob disease (CJD). The recent recognition of iatrogenic amyloid β cerebral amyloid angiopathy (CAA) and Alzheimer's disease, caused by inadvertent seeding of amyloid β pathology following historical medical procedures, raises concerns that these conditions might also be transmitted...