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Sarcopenic obesity and risk of falls: findings in Middle-aged and older Chinese population from CHARLS
CONCLUSION: Sarcopenic obesity is associated with an increased risk of falls among middle-aged and older adults, especially in longitudinal analyses. Age-stratified results suggest that the impact of SO on falls may be more pronounced in the middle-aged group. Our findings support the need for early identification and targeted interventions for individuals with SO to mitigate fall-related risks in aging populations.
Age-Related Alterations in Hippocampal Microstructure Quantified Using High-Gradient Diffusion MRI (dMRI) in an Unfolded Hippocampal Space
The hippocampus, a brain region critical for memory, undergoes significant age-related changes at both the macroscopic and microstructural levels. This study investigates these changes using high-gradient diffusion MRI (dMRI) data analyzed in an unfolded hippocampal space. We applied the Soma and Neurite Density Imaging (SANDI) model to quantify microstructural alterations in 72 cognitively healthy participants aged 19-85 years, scanned on a 3 T Connectome MRI scanner with a maximum gradient...
AI drives dramatic expansion of Chan Zuckerberg Initiative’s funding to end all diseases
Entering its second decade, philanthropy with Facebook fortune has shed social causes and now focuses on ambitious science dream
Daily briefing: ‘Mind captioning’ AI describes the images in your head
First-ever atlas of brain development shows how stem cells turn into neurons
‘Google Maps’ for Roman roads reveals vast extent of ancient network
An ATP-gated molecular switch orchestrates human messenger RNA export
Author Correction: TNF-mediated inflammatory skin disease in mice with epidermis-specific deletion of IKK2
Fluorescence lifetime clocks quantify senescence and aging
Naked mole rat cGAS sticks it out
The role of organizations in fostering innovation
Science, Volume 390, Issue 6773, November 2025.
Unlocking the potential of brassinosteroids: A path to precision plant engineering
Science, Volume 390, Issue 6773, November 2025.
Deep generative models design mRNA sequences with enhanced translational capacity and stability
Science, Volume 390, Issue 6773, November 2025.
Preventing hypocontractility-induced fibroblast expansion alleviates dilated cardiomyopathy
Science, Volume 390, Issue 6773, November 2025.
The anti-inflammatory activity of IgG is enhanced by co-engagement of type I and II Fc receptors
Science, Volume 390, Issue 6773, November 2025.
Direct targeting and regulation of RNA polymerase II by cell signaling kinases
Science, Volume 390, Issue 6773, November 2025.
Adipogenin promotes the development of lipid droplets by binding a dodecameric seipin complex
Science, Volume 390, Issue 6773, November 2025.
Repair of DNA double-strand breaks leaves heritable impairment to genome function
Science, Volume 390, Issue 6773, November 2025.