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How politics, bad timing, and skepticism left foundation stones of modern physics unrecognized

Creatine helped middle-aged adults gain muscle and strength even without a structured workout program in a new 12-week study. When combined with exercise and a calorie-reduced diet, it produced even greater strength gains while helping participants add lean tissue and lose fat. Researchers say the results strengthen the case for creatine as a potentially useful tool for maintaining muscle with age.

Scientists are developing a possible alternative to LASIK that reshapes the cornea without cutting it or using a laser. The technique uses a small electric potential and a specially shaped platinum lens to temporarily soften the cornea, allowing it to be molded in about a minute.

Depression may change which emotional faces children notice most, but the pattern appears to depend on family history. Children at higher familial risk became increasingly focused on sad faces, while lower-risk children with rising symptoms paid less attention to happy ones.

A massive MRI study found that Alzheimer’s disease, mild cognitive impairment, psychiatric disorders, and addiction are associated with distinct patterns of accelerated brain aging. The strongest effects appeared in Alzheimer’s and mild cognitive impairment, while ADHD and autism showed no significant overall difference.

Examination of genetic risk factors associated with neurodegenerative diseases has provided important mechanistic insights into the pathophysiology of these disorders, and it has implicated defects in lysosomal function as a key component of the neurodegenerative process. The lysosome has a primary role in mediating degradation of both intracellular contents and endocytosed material from the extracellular space. Aggregation of misfolded proteins is a pathological mechanism that is observed...

Oligodendrocytes (OLs) are brain cells that make myelin, the insulating sheath that supports nerve signal transmission. Although oligodendrocyte dysfunction is common in the central nervous system (CNS), how these cells respond to injury remains incompletely understood. Here we show, using mouse models and mouse tissue analyses, that OLs respond to demyelinating diseases by increasing the expression and secretion of serine protease inhibitor clade A member 3N (SERPINA3N). This transition of...