Aggregator

CONCLUSION: Cumulative heat exposure poses a significant risk to older adults' mental health, but community-based preventive health services can serve as vital institutional adaptation capital to buffer this risk. Prioritizing targeted health education to bridge the knowledge-action gap, alongside continuous health records monitoring in resource-constrained rural and middle regions, offers an equitable strategy for enhancing climate resilience in aging societies.

CONCLUSION: Health policies developed by the Ministry of Health that take into account the factors associated with healthcare access among older adults are crucial to improving service usage in this sociodemographic. This study presents empirical evidence that can help the Ministry of Health build effective access initiatives for older adults. In this sense, health policies that focus on criteria such as health status and health literacy may help to reduce obstacles to healthcare access and...

Dysregulation of RNA m⁶A modification has been implicated in Alzheimer's disease (AD), but the molecular mechanisms remain largely unclear. Here, we identified the presence of m⁶A on mitochondria-encoded messenger RNAs (mt-mRNAs) in the brain, with elevated levels correlated with amyloid-β (Aβ) deposition. Under physiological conditions, cytosolic m⁶A-modified mt-Nd4 is recognized and degraded by the m⁶A reader protein YTHDF2, thereby preventing aberrant activation of the RIG-I-MAVS innate...

Locomotor skills arise early in life and are maintained throughout an animal's lifespan, yet how this continuity is achieved despite major neural remodeling remains unclear. Using Drosophila, which undergoes complete metamorphosis, we show that the activity of embryonically established dopaminergic neurons (DANs) is essential for locomotion across all developmental stages and adulthood. Through stage-specific behavioral assays, optogenetics, in vivo brain imaging, and fluorescent neuronal...

Autophagy is a catabolic process that degrades cytoplasmic materials and is controlled by nutrient availability and signaling. The plasma membrane-associated pyruvate-solute carrier hermes (hrm) is required for regulation of the mechanistic target of rapamycin (mTOR) signaling and the activation of autophagy during development. Here, we screen for pyruvate-influencing genes that suppress the hrm mutant phenotype. We show that the inhibitory effect of hrm loss on autophagy depends on pyruvate...

CONCLUSIONS: Consumer-reported unmet LTSS needs are frequent, vary greatly across care settings and funding programs, and are associated with poorer QoL-related outcomes; highlighting substantial system-level gaps in the fragmented LTSS landscape and the need for coordinated investments and structural reforms to better meet the needs of individuals relying on these services.

Immune function across development, tissue repair, aging, and disease depends not only on signaling pathways but also on epigenetic architectures that determine whether coordinated transcriptional programs can be accessed and resolved. Increasing evidence indicates that epigenetic gene networks regulate the accessibility and reversibility of semi-stable immune states, shaping plastic, homeostatic, reparative, and degenerative configurations. We propose the concept of epigenetic transition...

The relation between cognitive impairment and skeletal muscle mass or physical exercise has been broadly discussed. However, the underlying molecular features have not been systemically investigated. Essential amino acids are the key factors for skeletal muscle mass. In the current study, we investigated the abundance of metabolites in the serum of ~ 1500 participants in various cognitive status from multiple centers. Our study revealed a positive correlation between serum level of essential AA...

Beyond their role in energy production, mitochondria also interact with other organelles through forming membrane contacts that serve as central hubs of cellular metabolism and signaling. Aberrant mitochondria-organelle communication has been implicated in various neurodegenerative diseases, but the underlying mechanisms and their pathological consequences remain poorly understood. Here, we reveal that tauopathy synapses exhibit excessive tethering of autophagosome/autophagic vacuole...

CONCLUSION: Higher SES was associated with higher QOL. Older age and widowhood were also associated with lower QOL. Thus, enhancing financial support, expanding social services, and prioritizing the socioeconomically disadvantaged and widowed elderly may contribute to promoting equitable and healthy aging.

CONCLUSIONS: Artificial intelligence holds significant promise for mitigating the global geriatric healthcare crisis exacerbated by demographic aging and nursing shortages. However, realizing its full potential requires a coordinated, multi-stakeholder approach to overcome the entrenched systemic, human, and social obstacles. The proposed roadmaps provide an actionable framework that may facilitate the development of artificial intelligence systems that are more efficient, equitable, and...

No abstract

CONCLUSION: These findings identify gaze fixation as a key determinant of increased spin-turn use during turning in older adults, whereby constraining gaze to the near walking surface alters visual information available for step planning and promotes maladaptive turning strategy selection.

Frequently ignored bodily rhythms may be skewing neuroscience experiments

Substance’s “remarkable” behavior could lead to devices powered by energy-rich gels