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A short burst of immunotherapy before surgery is delivering surprisingly powerful results for a specific type of colorectal cancer. Patients in a UK-led trial who received just nine weeks of pembrolizumab prior to surgery have remained cancer-free nearly three years later—an outcome that challenges the standard approach of surgery followed by months of chemotherapy.

A major 10-year clinical trial is turning one of the world’s most common knee surgeries on its head. Researchers found that trimming a damaged meniscus—a procedure long believed to relieve pain—offers no real benefit over placebo surgery. Even more surprising, patients who had the operation actually fared worse over time, with more symptoms, poorer function, faster progression of osteoarthritis, and a greater likelihood of needing additional surgery.

Two high-profile tools have been shown to make up data and “p-hack” their results

A chaotic sleep schedule in your 40s might be quietly setting the stage for heart trouble later. Researchers tracking thousands of people for over a decade found that those with highly inconsistent bedtimes—especially when they slept less than eight hours—faced about double the risk of serious cardiovascular events like heart attacks or strokes. Interestingly, it wasn’t when people woke up that mattered most, but how erratic their bedtime was.

A revived technique could reveal planets near their stars and the inner workings of galaxies