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Kirigami-inspired parachutes with programmable reconfiguration
Proteotoxic stress response drives T cell exhaustion and immune evasion
Hospitals have long been key for research, now their influence is broadening
These laser-cut discs turn into super precise parachutes
How research hospitals are meeting the world’s health challenges
Ancient viral DNA helps human embryos develop
Author Correction: Prophylactic TNF blockade uncouples efficacy and toxicity in dual CTLA-4 and PD-1 immunotherapy
Aging puts Leydig cells in a tough spot
Will your study change the world? This AI tool predicts the impact of your research
Six journal rejections and a major rethink: why I’m happy to admit to my research failures, and you should too
AI is dreaming up millions of new materials. Are they any good?
Trees of the Amazon are becoming even mightier
Wildfire smoke is charring your wine. This microbe could help
Bacteria already living on grapes can break down smoky chemicals that wreck flavor
AI reveals vast ‘ghost forests’ along U.S. coast
Machine learning method counts nearly 12 million dead trees, many likely killed by rising seas
Prehistoric camel art pointed to precious water sources in the Arabian Desert
Hunter-gatherers may have used the engravings to find water 12,000 years ago
‘Thrilled’ Indonesian scientists celebrate return of fossil trove from the Netherlands
The items to be returned, which include Java Man, were collected during the colonial era
Impact of senescent fibroblasts secretome in ovarian cancer dissemination
Aging is a significant risk factor in ovarian cancers, which remains one of the most lethal gynecological malignancies. Over 50 % of ovarian cancer cases occur in women aged 65 and older. During aging, senescent cells progressively accumulate in various tissues, contributing to structural and inflammatory changes in the tumor microenvironment. While recent studies have underscored the role of the senescent mesothelial cells in facilitating cancer cell dissemination, the contribution of senescent...
Stabilizing dual-phased perovskite towards high performance photovoltaics with enhanced batch stability and consistency
Fabricating high-performance perovskite solar cells (PSCs) with solution processing is conducive to low-cost commercial production, it is therefore rather critical to stabilize perovskite in both solution and solid phases. For this purpose, the speed-up ageing of perovskite solution in air was systematically studied and its severe spontaneous degradation was observed. To address this issue, we introduce 4-(trifluoromethyl) phenylhydrazine (TFPH) to modify the perovskite solution, which presents...
A centenarian single nucleotide polymorphism in collagen gene COL25A1 promotes longevity in C. elegans
Before human genome sequencing, a genome-wide study of sibling centenarian pairs identified a longevity-associated locus on chromosome 4. Here, we mapped the genes in this locus and identified a collagen gene, COL25A1. Introducing an SNP linked to longevity that changes a serine predicted to be phosphorylated to leucine in COL25A1, into col-99, the C. elegans ortholog, extended lifespan. These col-99(gk694263[S106L]) SNP-mutants exhibited enhanced innate immune-related transcriptional responses,...
Contribution of leukocyte telomere length to cardiovascular disease onset from genome-wide cross-trait analysis
Telomere shortening is a well-established marker of cellular aging and genomic instability. While the relationship between leukocyte telomere length and cardiovascular diseases has long been of interest, their genetic interplay remains incompletely understood. In this study, we observe substantial genetic overlap beyond genome-wide correlations and identify a potential causal relationship between leukocyte telomere length and coronary artery disease. Specifically, we discover 248 pleiotropic...