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Science, Volume 389, Issue 6759, Page 501-507, July 2025.

Science, Volume 389, Issue 6759, Page 494-500, July 2025.

Science, Volume 389, Issue 6759, Page 512-515, July 2025.

Science, Volume 389, Issue 6759, Page 462-462, July 2025.

Science, Volume 389, Issue 6759, Page 463-463, July 2025.

Science, Volume 389, Issue 6759, Page 463-463, July 2025.

Republicans on spending committee push back against proposed reorganization and overhead cuts

The nation’s vast deposits of critical minerals have drawn interest from Russia and the United States

Studies of soldiers and civilians could provide clues to diagnosis and treatments

War with Russia is reshaping research on everything from exotic drones to trauma care

Eating fallen fruit—or “scrumping”—plays a bigger part in many apes’ diets than scientists realized

A warming climate is enabling rodents to move north

Aging-related immune dysfunction is linked to cancer, atherosclerosis, and neurodegenerative diseases. This 6-week randomized controlled trial evaluated whether 2'-fucosyllactose (2'-FL), a human breast milk oligosaccharide with established benefits in infants and animal models, could improve gut microbiota and immune function in 89 healthy older adults (mean age 67.3 years). While the primary endpoint of cytokine response change was not met, 2'-FL supplementation increased gut Bifidobacterium...

Memory T cells are maintained in tissues as circulating effector-memory (T(EM)) and tissue-resident (T(RM)) populations for protective immunity, though the role of site and subset in memory persistence remains undefined. Here, we investigated age-associated dynamics of human T cells in lymphoid organs, mucosal sites, and blood over 10 decades of life using retrospective radiocarbon (^(14)C) birth dating, along with cellular, transcriptome, and epigenetic profiling. Memory T cells across...

Idiopathic pulmonary fibrosis (IPF) is a prevalent and deadly age-related disease characterized by chronic, progressive, and irreversible fibrosis. A key effector cell population in the fibroproliferative response is the fibroblasts. Fibroblast cell senescence gradually worsens during aging, and the acquisition of a senescence-associated secretory phenotype (SASP) turns senescent fibroblasts into pro-inflammatory cells. However, the mechanism promoting senescence in IPF, especially at the...

Exercise-induced release of irisin may contribute to the beneficial effects of exercise on brain health. Previous studies in healthy adults have shown ~15 % increase in short-term post-exercise irisin concentrations. However, previous research investigating the exercise-induced release of irisin in older populations is scarce and findings are highly variable. The present study investigated the effects of exercise mode and intensity on short-term acute post-exercise irisin concentrations in older...

Aging is associated with metabolic decline in the brain, increasing susceptibility to neurodegenerative diseases. While exercise is a well-established strategy to counteract these changes, no study has directly compared the effects of moderate-intensity continuous training (MICT) and high-intensity interval training (HIIT) on cortical and hippocampal energy metabolism-key regulators of brain plasticity in aging. To address this gap, we investigated how 4-week MICT and HIIT protocols, structured...

Parkinson's disease is characterized by loss of dopamine neurons that project to the dorsal striatum, and mutations in LRRK2 and GBA1 are the most common genetic causes of familial Parkinson's disease. Previously, we showed that pathogenic LRRK2 mutations inhibit primary cilia formation in rare interneurons and astrocytes of the mouse and human dorsal striatum. This blocks Hedgehog signaling and reduces synthesis of neuroprotective GDNF and NRTN, which normally support dopamine neurons...

The rising prevalence of Alzheimer's disease (AD) due to an aging population has made the search for effective treatments more urgent than ever. Previous studies have demonstrated that continuous ultrasound can depolymerize amyloid proteins, offering potential relief from AD. In this study, we present a portable, fully integrated wearable ultrasound system designed to promote amyloid protein depolymerization. The system comprises a flexible honeycomb ultrasonic array patch, a flexible printed...

Cellular cross-talk, mediated by membrane receptors and their ligands, is crucial for brain homeostasis and can contribute to neurodegenerative diseases such as Alzheimer's disease (AD). To find cross-talk dysregulations involved in AD, we reconstructed cross-talk networks from single-nucleus transcriptional profiles of 67 clinically and neuropathologically well-characterized controls and AD brain donors from the Knight Alzheimer Disease Research Center and the Dominantly Inherited Alzheimer...