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Science, Volume 390, Issue 6772, Page 495-502, October 2025.

Science, Volume 390, Issue 6772, Page 450-450, October 2025.

Science, Volume 390, Issue 6772, Page 449-449, October 2025.

Science, Volume 390, Issue 6772, Page 449-449, October 2025.

Researchers dismayed by the targeting of Preventing Chronic Disease’s editorial staff

Wood from gravesites can help reconstruct historic temperatures, floods, and droughts

Advance in Fischer-Tropsch process could make coal-to-liquid plants cleaner

Study is first to suggest our closest relatives think about their own thoughts

Researchers are competing to make “virtual cells” that could transform biomedicine by predicting gene activity and more

Universities aren’t training the specialists needed to exploit the country’s rich resources

Synthetic cocktail of llama and alpaca “nanobodies” protected mice from venoms of 17 snakes

Ocean planets could arise from rocks reacting with thick hydrogen atmospheres, lab experiments show

CONCLUSIONS: Evidence shows a lack of structured long-term care policy in sub-Saharan Africa. Given the increasing demand for long-term care, there is an urgent need for policies that address factors affecting quality of life and ensure better care for older people in these facilities. A protocol for the scoping review was preregistered on the Open Science Framework Registry on 9th September 2023 (https://osf.io/xm8r5/).

Spatial transcriptomics enables detailed mapping of gene expression within tissues, revealing spatial organization of cellular and molecular processes. However, generating such data is costly and technically challenging, and analysis requires advanced bioinformatics skills. Although public datasets are growing, existing databases offer limited tools for interactive exploration and cross-sample comparison. Here, we introduce DeepSpaceDB (www.deepspacedb.com), a next-generation spatial...

Alpha-1 antitrypsin (AAT) deficiency in younger people is well characterized, but the effects of elevated AAT levels in older age are unclear. We examined the effect of elevated AAT levels and mortality in a longitudinal cohort of older adults, alongside high-sensitivity C-reactive protein (hs-CRP) levels. This post hoc analysis of the ASPirin in Reducing Events in the Elderly (ASPREE) trial included 11,879 adults aged ≥ 70 years without prior cardiovascular disease, dementia or life-limiting...

Social isolation and loneliness are growing public health concerns worldwide; however, the independent and combined associations of change in social isolation and loneliness with mortality are yet to be elucidated. This study aimed to investigate these associations among older adults. This cohort study used data from the Chinese Longitudinal Healthy Longevity Survey, which recruited participants from 2002 to 2011. A total of 8,956 participants aged 65 years and older were included. We used data...

Brown adipose tissue (BAT) protects against obesity, diabetes, and cardiovascular disease. During BAT activation, macroautophagy is inhibited, while chaperone-mediated autophagy (CMA) is induced, promoting thermogenic gene expression, adipokine release, oxidative activity, and lipolysis. Aging reduces BAT function and lowers levels of LAMP2A, the rate-limiting CMA component. Pharmacological CMA activation restores BAT activity in aged mice. To explore the CMA's role in BAT, we generated...

Genome instability is a major factor contributing to cellular senescence. The rRNA gene (rDNA), a repetitive sequence array, is a highly unstable region of the genome. In budding yeast, this instability induces senescence and shortens the lifespan. While the importance of rDNA stability in the aging process is well recognized, the mechanism driving rDNA instability in old cells remains unclear. Using effective methods to isolate old cells in budding yeast, our observations suggest that...

CONCLUSION: The results demonstrate a notable correlation between exposure to heavy metals, specifically lead and cadmium, and the incidence of frailty in U.S. adults aged over 20 years, with a more substantial impact observed in female participants.

Mitochondria play a crucial role in cellular energy metabolism and homeostasis and are strongly implicated in aging and age-related diseases. The outer mitochondrial membrane protein voltage-dependent anion channel (VDAC) plays multiple roles in mitochondrial homeostasis, including transport of metabolites, ATP, and Ca^(2+) Dysregulation of VDAC levels has been associated with cancer, neurodegeneration, metabolic disorders, and aging. Previously, we demonstrated that elevated VDAC-1 levels in...