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Hyperactive 20<em>S</em> proteasome enhances proteostasis and ERAD in <em>C. elegans</em> via degradation of intrinsically disordered proteins
Age-related proteinopathies, including Alzheimer's and Parkinson's disease, are driven by toxic accumulation of misfolded and intrinsically disordered proteins (IDPs) that overwhelm cellular proteostasis. The proteasome clears these proteins, but its failure in disease remains unclear. We engineered a Caenorhabditis elegans model with a hyperactive 20S proteasome (α3ΔN) for selective 20S activation. α3ΔN markedly enhanced IDP and misfolded protein degradation, reduced oxidative damage, and...
Therapeutic extracellular vesicles as a cornerstone of medicine in the next decade with gerontological focus
Extracellular vesicles present a promising alternative to stem cells in regenerative medicine and gerontology. They offer significant advantages over cell transplantation, demonstrating potential for slowing aging and treating age-related diseases. Extracellular vesicles secreted by diverse cell types modulate inflammation, stimulate tissue regeneration, and exhibit anti-inflammatory and immunomodulatory properties. This work explores the therapeutic potential of extracellular vesicles as...
Natural history of liver fluke infection underpins epidemiological patterns of biliary cancer
Pathogens are major drivers of cancer globally and the processes of infection and carcinogenesis unfold over decades making them difficult to observe in human or natural populations. We investigate these hidden dynamics for the foodborne trematode Opisthorchis viverrini, which is a primary cause of biliary cancer (cholangiocarcinoma) and infects 12 million people in Southeast Asia. In tumors from patients exposed to O. viverrini, we find that the earliest chromosomal amplifications carrying...
Regulatory mechanisms of neuro inflammation from a gender perspective: interactions among astrocytes, sex hormones, and the gut-brain axis
No abstract
Daily briefing: Don't sideline Palestinian scientists after ceasefire, say experts
Should genetically modified wildlife be banned? Scientists weigh the risks
The world’s first plastics treaty is in crisis: can it be salvaged?
Dangerous ‘nitazene’ opioids are on the rise: researchers are worried
Future solitude
Portable muon beam could accelerate archaeology scans
European bats capture migrating birds and eat them on the wing
Current mosquitoes evolved more recently than previously thought
Rebuilding Gaza: don’t sideline Palestinian scientists, say experts
Author Correction: Loss-of-function mutations in PLD4 lead to systemic lupus erythematosus
As U.S. shutdown drags on, ‘it’s just one blow after another’
Federal researchers confront growing uncertainty about future
Utility of biological aging acceleration in capturing transitions of atrial fibrillation and dementia: a population-based study
The biological aging acceleration predicts both morbidity and mortality, while few investigations have examined its utility in evaluating transitions, e.g. development patterns, of atrial fibrillation (AF) and dementia. We aimed to investigate the utility of biological aging acceleration in predicting transitions of AF and dementia. A total of 402,955 participants (mean [SD] age: 56.5 [8.1] years; men: 45.9%) in the UK Biobank were included. Biological age was calculated using the phenotypic...
Naked mole rats live for decades - genetic tweaks reveal insights into ageing
No abstract
EpiClock; biological age measurement from blood DNA methylation using a minimal CpG marker set for high-throughput iPlex mass spectrometry assay for screening in drug development and population health
Measuring biological aging-the underlying rate of physiological decline-has become increasingly important in predicting disease risk, guiding personalized health strategies, and advancing age-targeted therapeutics. Unlike chronological age, biological age provides a more accurate reflection of an individual's functional health and longevity potential. DNA methylation-based epigenetic clocks are established tools for estimating biological age, but existing assays often require hundreds to...
Association between body roundness index trajectories and successful aging among older adults in China: A nationally representative longitudinal cohort study
CONCLUSION: This study highlights the need to monitor body changes in older adults and develop targeted health strategies to support successful aging.
mTOR dysregulation induces IL-6 and paracrine AT2 cell senescence impeding lung repair in lymphangioleiomyomatosis
Lymphangioleiomyomatosis (LAM) is a rare disease of women in which TSC2 deficient 'LAM cells' with dysregulated mTOR signalling and recruited fibroblasts form nodules causing lung cysts and respiratory failure. We examine if mTOR dysregulation can induce senescence and impair the response to lung injury in LAM. The senescence markers p21, p16 and the SenMayo gene set are increased in LAM lungs and colocalise with alveolar type 2 cells. LAM models induce mTOR dependent senescence in alveolar type...