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Regulated somatic hypermutation enhances antibody affinity maturation
VDAC2 loss elicits tumour destruction and inflammation for cancer therapy
A polyene macrolide targeting phospholipids in the fungal cell membrane
Widespread slow growth of acquisitive tree species
Drivers of avian genomic change revealed by evolutionary rate decomposition
Fluctuating magnetism and Pomeranchuk effect in multilayer graphene
Downscaling micro- and nano-perovskite LEDs
World’s tiniest LED display has pixels smaller than a virus
Why humans have puzzle-shaped cells
Asia leads rise in clean-energy research
Interplay of somatic mutations and epigenetic aging clocks
The biggest machine in science: inside the fight to build the next giant particle collider
Light pollution threatens fleet of world-class telescopes in Atacama Desert
Mystery force behind the universe’s accelerating expansion may not be so constant after all
Dark energy, assumed to be a cosmological constant, varied over time, new data show
When honey bees ‘disappeared’ on this small Italian island, wild bees feasted
Unusual experiment suggests managed bees can outcompete wild bees and contribute to their decline
This is the sharpest image yet of our universe as a baby
The Atacama Cosmology Telescope captures the afterglow of the Big Bang in unprecedented detail
Age-related differences in locus coeruleus intensity across a demographically diverse sample
Understanding the trajectory of in vivo locus coeruleus (LC) signal intensity across the adult lifespan and among various demographic groups, particularly during middle age, may be crucial for early detection of neurodegenerative diseases, which begin in the LC decades before symptom onset. Even though pathological changes in the LC are thought to begin in middle age, its characteristics across the adult lifespan, and its consistency and variation across demographic groups, remain not well...
Deciphering Novel Communication Patterns in T Regulatory Cells From Very Old Adults
Regulatory T cells (Tregs) are important in maintaining tolerance and are key players in immunity. In aging, increased Treg function along with low-grade inflammation has been reported. This dichotomy of enhanced Treg function along with inflammation highlights the importance of understanding Treg biology and communication patterns in the very old. In this proof-of-concept study, we demonstrate that aged Tregs (85 years) do not significantly communicate with CD4^(+) and CD8^(+) T effectors when...
TMBIM-2 orchestrates systemic mitochondrial stress response via facilitating Ca2+ oscillations
Neuronal mitochondrial function is critical for orchestrating inter-tissue communication essential for overall fitness. Despite its significance, the molecular mechanism underlying the impact of prolonged mitochondrial stresses on neuronal activity and how they orchestrate metabolism and aging remains elusive. Here, we identified the evolutionarily conserved transmembrane protein XBX-6/TMBIM-2 as a key mediator in the neuronal-to-intestinal mitochondrial unfolded protein response (UPRmt). Our...
An incidental finding during a brain plasticity study: substantial telomere length shortening after COVID-19 lockdown in the older population
The detrimental effects of lockdowns have already been proven by numerous studies, mainly using psychometric measurements. Since telomere shortening is a driver of aging and aging-associated disorders, including cognitive decline, the telomere length in the older population has been investigated in the current study. Measurements were taken over a 6-month period just before and during the 6 months that included the first lockdown. The cohort of 55 persons aged 64 to 70 years was investigated in...