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Cytotoxic chemotherapy typically results in the elimination of a fraction of the tumor with surviving cells entering a state of persistence or premature replicative senescence that can lead to recurrence. Here, we show that therapy-induced senescence is associated with robust up-regulation of Fas and/or TRAIL-R2/DR5 death receptors in vitro and in vivo. The latter receptors restricted entry to senescence and exerted selective pressure on senescent cells through promoting assembly of proapoptotic...

A tiny region deep within the brain has surprised scientists by revealing a remarkably sophisticated communication system. Previously thought to broadcast the same chemical signal throughout the brain, this region actually sends targeted messages that help control learning, attention, and behavior, according to new research in mice.

Ancient DNA connects teeth in a cave offering to people buried in faraway elite tombs

Toothless, turkey-size oddity may have evolved alongside the emergence of flowering plants

Health secretary wants a leader of “metabolic psychiatry” movement to direct $2.2 billion agency

Detailed recordings reveal an unexpected way neurons represent perceived and unnoticed images

Cambridge researchers have created a groundbreaking $10 optical sensor that delivers the precision of laboratory equipment in a device small enough for wearable technology. It identified foods, plastics, and medicines with 100% accuracy in tests and demonstrated the ability to monitor blood glucose, alcohol, and other health markers without invasive procedures.

Researchers have uncovered a hidden immune defense capable of attacking small cell lung cancer, an extremely aggressive disease that often escapes conventional treatments. The specialized immune cells can recognize and destroy cancer cells even when tumors have disguised themselves from the immune system.

A surprising two-year clinical trial found that fish oil supplements successfully delivered omega-3s to the brain but failed to improve memory or protect against Alzheimer's-related brain shrinkage. Researchers suspect that getting these nutrients through a healthy diet may offer benefits that supplements alone cannot provide.