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A Cluster of Three snoRNAs Including Jouvence Required in the Gut Determines Lifespan and Confers Neuroprotection Through Metabolic Parameters

2 weeks 3 days ago
In our society, the aging of the population is a major public health concern. Recently we have identified a new snoRNA (jouvence) in Drosophila, and showed that its deletion (F4) reduces lifespan, while its overexpression increases it. F4 deleted flies also present neurodegenerative lesions and a deregulation of metabolic parameters such as triglycerides and sterols. However, a deeper characterization of this genomic locus has revealed the presence of two additional snoRNAs. Here, we have...
Sara Al Issa