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Thai Older Persons' Digital Capacity and Application of Technology for Healthy Aging: A Mixed-Method Study
CONCLUSION: Therefore, it is urgent to enhance digital skills and internet use among older populations to promote healthy aging.
Exploring the Psychosocial and Economic Challenges of Elders in Debre Tabor Metropolitan City: A Holistic Perspective
The rapid increase in the global aging population presents significant psychosocial and economic challenges, especially in underdeveloped nations. This study examines the experiences of elderly retired government employees (65+) in Debre Tabor Metropolitan City, Ethiopia, using a qualitative hermeneutical phenomenological approach. Structured interviews with 15 participants revealed key issues affecting their well-being. Findings show severe isolation and loneliness, with many feeling abandoned...
Chaperone-mediated autophagy as a sex-specific modulator of synaptic proteostasis and neural function
Chaperone-mediated autophagy (CMA), once considered a secondary or auxiliary degradation pathway, is now recognized as a central regulator of synaptic proteostasis. A recent study by Khawaja et al. (2025) in Nature Cell Biology provides compelling evidence that CMA actively remodels the synaptic proteome in a sex-specific manner. Using a conditional knockout strategy based on Lamp2a-floxed mice crossed with a Camk2a-Cre driver line to achieve excitatory neuron-specific deletion of Lamp2a in...
A multi-tissue integration of immunocytes and inflammaging biomarkers predicts biological age through LASSO-optimized modeling
Immunosenescence, a recognized hallmark of aging, is characterized by imbalances in immunocyte populations and a state of chronic inflammation. However, the tissue-specific dynamics of these changes and their potential as predictive biomarkers for aging remain poorly characterized. In this study, we established a multi-tissue immunological signature as a robust predictor of biological age by integrating immunocyte and cytokine profiling. Using Sprague-Dawley (SD) rats from five age groups (1-12...
Effect of high-intensity interval training and resistance training on the follistatin and myostatin levels in gastrocnemius muscle of aged female rats
Myostatin and follistatin are the regulators of muscle growth and pivotal proteins that regulate muscle tissue function. An integrated approach is HIIT and resistance training provides a holistic strategy for promoting healthy aging and maintaining functional abilities, potentially through the modulation of myostatin and follistatin levels. This study aims to assess the effect of high-intensity interval training and resistance training on myostatin and follistatin protein concentrations in aged...
Extracellular Vesicles Favor Early Peripheral Immunosenescence Through Modulation of the Senescence-Associated Secretory Phenotype in HIV Infection
HIV infection induces chronic immune activation, predisposing people living with HIV (PLWH) to early immunosenescence. It is essential to understand the mechanisms behind the senescence-associated secretory phenotype (SASP). This study investigates the role of extracellular vesicles (EVs) in peripheral immunosenescence in HIV infection associated with SASP modulation. Biological and in silico analyses were performed to explore the crosstalk between EVs, miR-21-5p, and SASP. Plasma EVs from PLWH...