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Adipose tissue (AT) is now recognised as a dynamic immunometabolic organ in which coordinated interactions between adipocytes, stromal cells, vascular elements, and resident immune populations are essential for maintaining metabolic homeostasis and endocrine function. Beyond its classical role in energy storage, AT actively regulates local and systemic immune responses through the production of adipokines, cytokines, chemokines, and lipid mediators. Among adipose-resident immune cells, B...

Aging can be experimentally induced in Hydra oligactis, making it an exception among the "immortal" cnidarian genus Hydra. In response to cold temperatures, H. oligactis polyps switch from asexual to "emergency" sexual reproduction and eventually age and die. We used GC-MS-based metabolite profiling to characterize cold-induced (CI) metabolic reprogramming during concurrent sexual differentiation and aging in H. oligactis. Metabolites in four clusters either decreased or increased progressively...

Eating within a shorter daily window may help protect certain thinking skills as people age. In a small six-month trial, older women who limited eating to about 8 to 9 hours a day performed better on planning and problem-solving tests than those who ate over 12 hours. Both groups lost similar amounts of weight, hinting that when people eat could matter in addition to how much they eat.

A controlled mouse study has provided direct evidence that inherited genetics can steer how cancer begins and evolves after DNA damage. The discovery could eventually help doctors better predict cancer risk and tailor screening and treatments to each patient.

The Oregon National Primate Research Center could change its name and shift its focus to nonanimal studies

试验酿成灾难性悲剧后，受害者父母寻求问责，《科学》与 Retraction Watch 联合调查发现

Stripped-down behemoth promises new insights into how galaxies grow, astronomers say

Satellite data reveal in unprecedented detail how groundwater reservoirs permanently lose their ability to store water

More than half of AI “unicorns” have never published a paper or preprint

More than a year after failed clinical trial, Shanghai Jiao Tong University School of Medicine promises “serious action”