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Daily briefing: Tiny bones from Neanderthal fetus point to downfall of the species
These medical X-rays are all deepfakes — and they fool even radiologists
Antimatter has been transported for the first time ever — in the back of CERN’s truck
Can a mouse be cloned indefinitely? Decades-long experiment has answers
‘Zombie cells’ return from the dead — after a genome transplant
Why it’s hard to guess the high note
How DNA in dirt is shaking up the study of human origins
Why AI hasn’t caused a job apocalypse — so far
How the war in Iran is reshaping the energy landscape
UK scraps airborne lab that tracks climate, pollution and weather systems
Salt lakes are shrinking and expanding, causing havoc in conservation
Scientists should join collaborative online editing communities for biodiversity
Marine life is a silent casualty of armed conflicts
Author Correction: 7-Dehydrocholesterol is an endogenous suppressor of ferroptosis
NASA plans to send a nuclear-powered spacecraft to Mars in 2028
Spacecraft would release helicopters to explore martian surface
Correction: Gerontology lost in translation from demography to biology of aging and back
No abstract
Aging is not a disease: an evolutionary and comparative biological reappraisal
The question of whether aging should be classified as a disease has gained prominence in geroscience, fueled by advances in molecular biology and the aspiration to develop interventions that mitigate age-associated functional decline. However, evolutionary models describe aging as an emergent consequence of declining selection gradients and life-history trade-offs rather than as a deviation from species-typical function. Comparative data across taxa reveal substantial heterogeneity in aging...
Wobble-board instability re-orthogonalizes postural geometry in older adults through exogenous constraint
Postural control is expressed as intermittent organization of center-of-pressure (CoP) motion on a saddle-shaped manifold typically aligned with the anteroposterior (AP) and mediolateral (ML) axes. When task demands reorient postural focus, this saddle rotates away from the AP-ML alignment yet preserves orthogonal axes that indicate directions of greatest and least fractal temporal correlations in sway. Preserved orthogonality appears to reflect a balance between endogenous fractal fluctuations...
Identifying a cancer therapeutic target: Cell-SELEX identifies a membrane protein for aptamer-mediated growth suppression
The identification of functional ligand-membrane protein interactions under native conditions remains a major challenge in cancer biology. Using cell-systematic evolution of ligands by exponential enrichment, we identified a high-affinity DNA aptamer, CW06, against breast cancer cells. To precisely identify its native membrane target, we developed Aptamer-mediated Metabolic Glycan-labeling Proximity Hybridization (Apt-MGPH), which revealed the mitochondrial solute carrier SLC25A24 as the...
Unveiling the developmental and tumor-suppressive roles of the p53 variant p53psi
Through alternative splicing, the TP53 gene can generate multiple protein isoforms with distinct biochemical properties. The p53psi isoform has been identified as a shorter variant than full-length p53 as it lacks nuclear localization, oligomerization, and part of the DNA binding domains due to the use of an alternative 3' splice site in intron 6. Several TP53-truncating mutations, including those producing p53psi, have been detected in a significant proportion of human tumors. However, the...