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With an ageing population and the persistence of unhealthy lifestyle behaviours, health-care systems are challenged by a growing number of individuals living longer with cardiovascular disease and its sequelae. The evolution of cardiac rehabilitation, from a group exercise-based programme to encompassing all aspects of secondary prevention, has led to the ultimate objective of achieving lifelong cardiovascular health for all. In this World Heart Federation Roadmap, we present a united and...

Brain white matter undergoes structural and functional alterations linked to late-life cognitive decline, but the cellular and molecular basis of its selective vulnerability remains incompletely defined. Here, in naturally aged mice, we demonstrate that senescent and disease-associated microglia (DAM) phenotypes converge in hippocampal-adjacent white matter, particularly in the fimbria. Using regional gene expression profiling, immunolabeling, GeoMx digital spatial profiling and CosMx spatial...

Chronic pruritus (or itch) is a common condition associated with aging; however, the neural mechanisms driving age-related itch hypersensitivity remain largely unknown. Here, we investigated the role of serotonergic signaling in modulating itch sensitivity during aging. Aged mice exhibited enhanced mechanical alloknesis without changes in spontaneous scratching behavior, indicating that aging selectively affects mechanically evoked itch. Consistent with this phenotype, aged mice showed elevated...

CONCLUSIONS: The findings contribute to the identification of groups most vulnerable to low social support and low social participation among older adults with disabilities. Because these patterns vary according to the type of social support and type of participation, this study highlights the importance of targeted strategies to promote social inclusion in aging populations.

Accelerated cellular perturbations such as cellular senescence, neuroinflammation and oxidative stress are hallmarks of Alzheimer's disease, a neurodegenerative disease associated with memory decline. However, the senolytic effects of silymarin, a flavonolignan with known antioxidant and anti-inflammatory properties, on memory decline remain unknown. Hence, we investigated the effect of silymarin on doxycycline-mediated senescence and exacerbated neuroinflammation in lipopolysaccharide-induced...

Biological ageing is a heterogeneous process that shapes susceptibility to chronic disease. However, whether ageing patterns diverge within clinically defined type 2 diabetes (T2D) subgroups remains unclear. We investigated whether epigenetic age acceleration (EAA) differs across T2D phenotypes and whether these patterns relate to subsequent renal vulnerability. We included 607 multi-ethnic Asians with recent-onset T2D previously classified into three clinically distinct subgroups: mild...

Researchers debate whether tool produces genuinely novel tongues, or simply spits out a remix

The autograph accompanies formulas devised to sync calendars with planetary movement