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Several studies suggest that higher skeletal muscle mass (SMM) may be associated with a lower risk of adverse cardiometabolic outcomes. However, the relationship between SMM and cardiometabolic multimorbidity (CMM) has not been evaluated. We investigated the prospective association between height-indexed SMM and CMM risk in an older population. Data were analyzed from 3348 participants (mean age 64 years; 45.1% men) in the English Longitudinal Study of Ageing who were free of hypertension,...

Hawking’s signature prediction may prevent vexing singularities from forming

Before antiretroviral drugs reached South Africa, high death toll shaped immune system genes

No abstract

CONCLUSIONS: SPH provides meaningful prognostic information for depressive symptoms in older adults, with performance comparable to objective health measures. Its simplicity supports a potential use in screening and research contexts.

Impaired immune responses are a key feature of aging; however, there are few laboratory tests that link these responses to clinical outcomes. Interferon-gamma release assays (IGRAs) for tuberculosis screening quantify release of interferon-gamma by T-cells, and the difference between unstimulated and mitogen-stimulated T-cells is assessed for test validity. We assess this measure's relationship with all-cause mortality. We obtained the most recent negative and indeterminate outpatient IGRAs from...

High-affinity, allergen-specific immunoglobulin E (IgE) responses play a central role in allergic disease, yet the biological basis of their persistence remains incompletely understood. Studies examining IgE ontogeny have yielded diverse and often conflicting results regarding the longevity of IgE-expressing B cells, their developmental relationship to IgG1^(+) intermediates, and their dependence on germinal center (GC) reactions. In this review, we summarize the current knowledge of the...

No abstract

Gain-of-function screening in Drosophila melanogaster provides a powerful approach for identifying genes that modulate lifespan; however, induction strength and environmental stress can substantially influence phenotypic outcomes. Here, we performed a pilot Gene Search (GS)-based overexpression screen using a heat-inducible hs-GAL4 driver and compared lifespan analyses at 25 °C and 30 °C to evaluate the impact of induction conditions on the detectability of lifespan-modulating genes. Induction...

Machine learning can unravel heterogeneous patterns of brain aging and neurodegeneration, but existing methods offer limited insights into disease progression due to reliance on cross-sectional data. We introduce Coupled Cross-sectional and Longitudinal Non-negative Matrix Factorization (CCL-NMF) to capture dominant brain aging patterns by simultaneously leveraging cross-sectional and longitudinal neuroimaging data. CCL-NMF allows individuals to co-express multiple patterns, capturing mixed...

Dismissal of the National Science Board is widely seen as latest move to erase NSF’s independence