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O-GlcNAc modification is a key cellular signal, but its role in regulating senescence-associated transcription remains poorly understood. Here, we apply a time-resolved chemical genomics strategy to map dynamic O-GlcNAc chromatin-associated proteins (OCPs) during oncogene-induced senescence (OIS) in primary human fibroblasts. Chromatin O-GlcNAc modification continues to accumulate, while 1,987 senescence-associated OCPs undergo dynamic shifts in genomic occupancy across diverse epigenetic...

Reproductive history is closely linked to health, yet its relationship with biological aging and survival remains uncertain. We investigated this in the Finnish Twin Cohort, a population-based study that enables modeling of full childbearing history while controlling for common risk factors, through questionnaires and civil registries. We model the association between reproductive trajectories and survival in 14,836 women, and assess biological aging in a subset of 1054 participants using the...

Stable self-assembled monolayers (SAMs), such as (2-(9H-carbazol-9-yl)) ethylphosphonic acid (2PACz), are crucial for reducing interfacial energy loss in high-performance perovskite solar cells (PSCs). However, the inherent aggregation tendency of SAMs at the buried interface hinders the device's performance. Here, we propose a surfactant-assisted strategy to inhibit the aggregation of 2PACz by functionalizing cetyltrimethylammonium bromide (CTAB). Capitalizing on its distinctive electrostatic...

The challenge of dendrite growth limiting metal battery lifespan, despite extensive chemical composition optimizations for artificial solid electrolyte interphases (ASEIs), necessitates the development of ASEI design routes. Regulating the ASEI crystallographic microstructure offers a promising yet underexplored solution with efficacy uncertainty. Critical issue lies in what is the optimal crystallographic microstructure state. Using the ZnS ASEI in aqueous Zn batteries as a case study, here we...

Thyroid dysfunction and diabetes mellitus frequently occur together, with evidence showing higher rates of each condition in individuals affected by the other. Beyond their statistical association, emerging research indicates shared mechanisms involving autoimmunity, obesity, ageing and insulin resistance, which might explain their bidirectional relationship. This Review synthesizes current evidence on these links, with a particular focus on how thyroid dysfunction influences glycaemic control...

CONCLUSIONS: This validated framework integrates computational objectivity with expert knowledge for evaluating rural school conversion feasibility. It provides practical guidance for policymakers and developers to address rural elderly care shortages through sustainable infrastructure adaptation, applicable to aging societies globally.

CONCLUSIONS: These results suggest that MHL, along with key demographic and clinical factors, plays a significant role in predicting high-risk GSI among older adults.

No abstract

Somatic variants are increasingly recognized as contributors to diverse non-cancer, developmental, and aging-related disorders. However, most tools for detecting somatic single-nucleotide variants (sSNVs) were designed for DNA sequencing and primarily tailored to cancer datasets, leaving a critical gap in harnessing the rich potential of RNA-seq for sSNV identification, particularly in non-cancer tissues with low mutation rates. Here, we introduce RNA-MosaicHunter, a novel bioinformatic tool for...

Mutations in the TANGO2 gene are associated with a severe neurometabolic disorder in humans, often presenting with life-threatening metabolic crisis. However, the function of TANGO2 protein remains unknown. It has recently been proposed that TANGO2 transports heme within and between cells, from areas with high heme concentrations to those with lower concentrations. Here, we demonstrate that prior heme-related observations in Caenorhabditis elegans lacking TANGO2 homologs HRG-9 and HRG-10 may be...

Telomere length is a critical determinant of telomere function and hence chromosome stability. Critically short telomeres induce cellular senescence and division arrest, which eventually may lead to devastating age-related degenerative diseases. Conversely, maintenance of telomere length is a hallmark of cancer. How telomere set-length is established and molecular mechanisms for telomere-specific length regulation remained unknown. Here, we detail a mechanism of a telomere-specific set-length...

Somatic variants are increasingly recognized as contributors to diverse non-cancer, developmental, and aging-related disorders. However, most tools for detecting somatic single-nucleotide variants (sSNVs) were designed for DNA sequencing and primarily tailored to cancer datasets, leaving a critical gap in harnessing the rich potential of RNA-seq for sSNV identification, particularly in non-cancer tissues with low mutation rates. Here, we introduce RNA-MosaicHunter, a novel bioinformatic tool for...

Science, Volume 391, Issue 6781, January 2026.

Science, Volume 391, Issue 6781, January 2026.

Science, Volume 391, Issue 6781, January 2026.

Science, Volume 391, Issue 6781, January 2026.

Science, Volume 391, Issue 6781, January 2026.

Science, Volume 391, Issue 6781, January 2026.