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[This retracts the article DOI: 10.3389/fnagi.2017.00134.].

[This retracts the article DOI: 10.3389/fnagi.2017.00066.].

Endometriosis is a benign yet invasive disease characterized by ectopic endometrial growth and immune remodeling. While emerging evidence implicates cellular senescence in disease progression, the underlying mechanisms remain largely undefined. In this study, we identified marked heterogeneity in senescence across ectopic lesions and observed that P21-activated kinase 4 (PAK4) was consistently upregulated in senescent cells. Mechanistically, senescence induced PAK4 expression, which in turn...

Researchers find evidence that duikers, hunted and eaten across sub-Saharan Africa, can harbor the deadly virus

Researchers still aren’t sure how H5N1 influenza spreads between cows and from farm to farm

Eruptions could be triggered when bubbles vanish into magma—not when they burst out

Aging is a myeloid-biased process, i.e., the differentiation of myeloid cells increases, while the lymphoid lineage declines. Cellular senescence increases the secretion of inflammatory mediators which skew hematopoiesis toward myeloid cell generation. Myeloid cell nuclear differentiation antigen (MNDA) is a type-1 interferon (IFN)-inducible factor which is mainly expressed in the cells of the granulocyte-monocyte lineage, especially it is enriched in M2 macrophages and myeloid-derived...

Male reproductive aging is a complex physiological process characterized by progressive deterioration in spermatogenesis, hormonal imbalance, and increased susceptibility to infertility and genetic disorders. This review comprehensively summarizes the pivotal molecular mechanisms underlying testicular aging, with emphasis on mitochondrial dysfunction, oxidative stress, DNA damage, autophagy impairment, chronic inflammation, cellular senescence, and dysregulated apoptosis. Accumulating evidence...

CONCLUSION: We showed that increased USI values are associated with sarcopenia. This study shows USI as a sensitive, non-invasive marker for sarcopenia classification, supporting its use in clinical screening and monitoring of muscle changes in older adults.

Aging is a multifaceted process impacting physiological, genomic, metabolic, and immune functions. This study investigates the role of luminal fecal exosomes (LFEs) in age-associated metabolic dysfunction. We analyzed LFEs from young (3-month) and old (24-month) male and female C57BL/6 mice to characterize age-related differences in exosomal proteomic and miRNA cargos. To explore interactions between LFEs and the gut microbiome, naïve young mice were gavage fed with LFEs from old donors,...

No abstract

The integration of environmental cues into cellular programs is crucial for cell function. Yet, how this integration is modulated due to cellular aging remains unclear. We propose that the 3D chromatin organization filters these signals and investigated how age-related chromatin changes in human dermal fibroblasts affect responses to mechanical tension and TGF-β. Young fibroblasts exhibited synergistic gene expression enhancement in response to combined stimuli, a response that was markedly...

Autism spectrum disorder (ASD) is a neurodevelopmental disorder, and maternal immune activation (MIA) is highly implicated in neuropathology and ASD-like phenotypes in offspring. However, the underlying regulatory mechanisms of ASD are multifactorial and remain largely unknown in MIA offspring. Here, we performed spatial transcriptome and single-nucleus RNA sequencing (snRNA-seq) analysis in MIA offspring brain to explore the neurobiological features of ASD. We obtained MIA-induced genes and...