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Bound by a handshake

2 weeks 6 days ago
Science, Volume 391, Issue 6789, Page 988-989, March 2026.
Moritz T. Meyer and Howard Griffiths

In Other Journals

2 weeks 6 days ago
Science, Volume 391, Issue 6789, Page 1001-1002, March 2026.
Corinne Simonti, and Jesse Smith, Sarah H. Ross, Cheri Sirois, Bianca Lopez, Jelena Stajic, Di Jiang, Michael A. Funk, and Sumin Jin

Planting a seed

2 weeks 6 days ago
Science, Volume 391, Issue 6789, Page 1078-1078, March 2026.
Gilberto Lopez

Science stories for young readers

2 weeks 6 days ago
Science, Volume 391, Issue 6789, Page 978-984, March 2026.
Lauren Kmec, Jennie Erin Smith, Valerie Thompson, Michael Funk, Keith T. Smith, Jennifer Sills, Madeleine Seale, Chloe Seale, Alice Seale, Matthew Warren, Kiaan Suri-Warren, Bianca Buehler, Christie Wilcox, Yevgeniya Nusinovich, Isaac Nusinovich Ucko,…

Single-nucleus multiomic profiling of the aging mouse substantia nigra reveals conserved gene alterations linked to Parkinson's disease

3 weeks ago
Parkinson's disease (PD) is a prevalent neurodegenerative disorder predominantly affecting individuals over 60. Its motor symptoms stem from the deterioration of dopaminergic neurons within the substantia nigra. Despite aging being a significant risk factor, the specific mechanisms linking aging and PD pathology remain unclear. Leveraging advancements in single-cell genomics, this study utilizes single-nucleus multiome sequencing to capture transcriptomic and epigenetic profiles from 40,125...
Kangli Wang

Resilience-Based Longevity Medicine: A Multiscale and Dynamic Integrative Framework

3 weeks ago
Population ageing has widened the gap between lifespan and healthspan, with frailty and functional dependence increasingly shaping late-life outcomes. Yet trajectories in older age remain highly heterogeneous, suggesting that vulnerability is not determined by chronological age alone but by differences in adaptive capacity. This review reframes resilience as a dynamic, multilevel construct linking molecular maintenance, regulation within the immune-endocrine-autonomic "vital systems triad," and...
Mathias Schlögl