Aggregator
Structures of Marburgvirus glycoprotein and its complex with NPC1 receptor
Multidimensional profiling of heterogeneity in supratentorial ependymomas
Capturing dynamic phage–pathogen coevolution by clinical surveillance
A large-scale coherent 4D imaging sensor
The dynamic basis of G-protein recognition and activation by a GPCR
This fish shouldn’t exist — the weird genetics of clonal vertebrates
This supernova is too bright – now astronomers might know why
Microglia protein profiles in CSF across Alzheimer’s disease clinical stages
Microfluidics device recovers oocytes for IVF
Statistics reach a ‘crisis point’: nations struggle with a critical lack of data
Physics at risk: UK science leader on what’s wrong with the latest funding cuts
China pledges billion-dollar spending boost for science
Author Correction: Gut stem cell necroptosis by genome instability triggers bowel inflammation
After 35 years, Ig Nobel ceremony to leave the U.S.
Finances and Trump policies underlaid the decision to move the satirical science event to Switzerland
Ancient Peruvians transported live parrots across the Andes
Pre-Inca elites wore headdresses made of feathers from Amazonian macaws
These ants navigate with a newly discovered ‘Moon compass’
Insects must perform tricky internal calculations to travel in a straight line
Why do rodents gnaw? Because it feels good
Newly mapped brain circuitry in mice links tooth grinding to pleasure pathways
Resident tissue macrophages maintain intraocular pressure homeostasis
Intraocular pressure is tightly regulated by the conventional outflow tissues, preventing ocular hypertension that leads to neurodegeneration of the optic nerve, or glaucoma. Although macrophages reside throughout the conventional outflow tract, their role in regulating intraocular pressure remains unknown. Using macrophage lineage-tracing approaches, we uncovered a dual macrophage ontogeny with distinct spatial organization across the mouse lifespan. Long-lived resident tissue macrophages were...
Sleep deprivation exhibits an age-dependent effect on infraslow global brain activity
Infraslow (<0.1 Hz) global brain activity, quantified by the global mean blood-oxygenation-level-dependent (gBOLD) signal in resting-state functional magnetic resonance imaging (fMRI), is elevated during sleep and coupled to cerebrospinal fluid (CSF) dynamics, a key pathway for the brain waste clearance implicated in neurodegenerative disorders such as Alzheimer's disease. However, the effect of sleep deprivation on gBOLD activity and its interaction with aging remain poorly understood. Using a...
Histone modification clocks for robust cross-species biological age prediction and elucidating senescence regulation
Histone modifications represent an untapped resource for biological age prediction that overcomes limitations of traditional DNA methylation-based epigenetic clocks. Here, we developed and validated histone modification-based epigenetic clocks by systematically analyzing publicly available ChIP-seq datasets spanning six tissue types and six histone marks. We identified age-associated loci and constructed 36 tissue-specific epigenetic clocks that demonstrated strong resilience to technical and...