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Authorship for sale: <i>Nature</i> investigates how paper mills work
Making slabs and sleepers from old appliances
NINJ1 regulates plasma membrane fragility under mechanical strain
Boosting angiotensin-converting enzyme (ACE) in microglia protects against Alzheimer’s disease in 5xFAD mice
Medicine’s rapid adoption of AI has researchers concerned
How our student journal club built on sand developed strong foundations
Do our observations make reality happen?
Want to enhance lab safety? Try a little role playing first
How DEI is misunderstood — and the real route to gender equality
NIH terminates network aimed at stopping pandemics before they start
Agency calls research to identify viral threats “unsafe”
Open-access revolution is squeezing scientific societies’ budgets, survey shows
Decline in journal revenues puts scholarships, advocacy, and other activities at risk
Immune cells can make female deer grow antlers
Macrophages help male deer build their impressive headgear, new study suggests
Trump budget proposes killing nursing research institute
A tiny sliver of NIH, it has provided an evidence base for bedside care, shrinking mortality and saving dollars
Brain precapillary sphincters modulate myogenic tone in adult and aged mice
Brain precapillary sphincters, which are surrounded by contractile pericytes and are located at the junction of penetrating arterioles and first-order capillaries, can increase their diameter by ~ 30% in a few seconds during sensory stimulation, allowing for rapid control of capillary blood flow over a wide dynamic range. We hypothesized that these properties could help precapillary sphincters maintain the capillary blood flow and shield the downstream capillaries during surges in blood...
AGE-PAIRS: Pilot of an Aging Education Mentorship Program Between Older Medical School Alumni and Medical Students
No abstract
The influence of chronic knee pain and age on conditioned pain modulation and motor unit control
CONCLUSION: Contrary to our hypothesis, older adults displayed more efficient heat-CPM, independent of chronic pain. Similarly, motor unit control was mostly influenced by age but not chronic knee pain. These findings suggest that age-related changes in pain modulation and motor unit behavior may play a greater role in neuromuscular function than the presence of chronic pain itself.
‘A big win’: Dubious statistical results are becoming less common in psychology
Fewer papers are reporting findings on the border of statistical significance, a potential marker of dodgy research practices
U.S. military trims access to its critical sea ice measurements
Data gaps come as Arctic sea ice shrinks to near-record lows
On-demand microglia deliver the therapeutic payload in Alzheimer's disease
In this issue, Chadarevian et al. showed that engraftment of human iPSC-derived microglia (iMG) engineered to express secreted neprilysin (sNEP) under the plaque-responsive CD9 promoter reduces amyloid burden, neuronal damage, and inflammation in an Alzheimer's disease (AD) mouse model.¹ These findings establish a cell-based strategy to treat neurological diseases.
A new era in regenerative medicine: Cell replacement therapy for Parkinson's disease is on the horizon
Parkinson's disease (PD), characterized by the selective loss of midbrain dopaminergic neurons (mDANs), is a promising target for cell replacement therapy. Two recent clinical trials¹^(,)² published in Nature report the safety and potential efficacy of human pluripotent stem cell-based approaches, representing a major milestone in regenerative medicine for PD.