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Global understanding of arterial aging remains limited despite its well-recognized medical and economic impact, hindering the development of effective mitigation strategies. The aorta, the major elastic artery, experiences a loss of homeostasis during aging that results from highly complex interactions. A promising approach to unravel the underlaying mechanisms is to investigate how aging affects the aortic transcriptome, leveraging the tremendous technological advances in RNA sequencing...

CONCLUSION: Combining aerobic exercise with cognitive training improves clinical outcomes in older adults with MCI and may influence stress-related neurobiological pathways. This multimodal approach represents a promising, non-pharmacological strategy for mitigating age-related cognitive decline.

CONCLUSION: Liver fat accumulation and fibro-inflammation were associated with higher brain-PAD, with fibro-inflammation playing a key role. These associations may be attenuated in individuals with optimal lifestyle behaviors, suggesting a potentially modifiable target for intervention.

CONCLUSION: Socioeconomic disadvantages, reflected in lower education, income, and employment, were associated with a higher incidence of depressive symptoms. Addressing these inequalities within integrated chronic disease and mental-health care may help prevent late-life depression.

More than 60 countries are off track to meet U.N. target for 2030—even though solutions exist