Aggregator
Prevalence of anaemia and associated factors among geriatric population from rural Mangalore: a cross-sectional study
CONCLUSION: This study revealed that one-fourth of the study population had anaemia. The overall prevalence of anaemia was equal in males and females. The most common type of anaemia was the normocytic normochromic type and there was a significant association between anaemia and characteristics such as age, number of comorbidities and diabetes mellitus.
Personalized biomarkers of multiscale functional alterations in temporal lobe epilepsy
Temporal lobe epilepsy (TLE) is the most common pharmacoresistant epilepsy in adults, yet few patients receive curative surgery due to diagnostic and prognostic uncertainty. In a multicenter cohort, we analyzed multimodal MRI and clinical data from 282 TLE patients, 298 healthy controls, and 45 disease controls. Patient-specific deviations from typical lifespan trajectories of intrinsic brain function were mapped using normative modeling. Regional functional alterations were heterogeneous but...
Solitary eating is linked to reduced brain volume in cognitively unimpaired individuals and possible future cognitive decline
Social isolation and poor nutrition are recognized risk factors for cognitive decline in older adults. However, the relationship between solitary eating, brain structure, and dietary patterns remains unclear. This study investigated the relationship between solitary eating, brain structure, and diet in healthy older Japanese adults. A total of 727 cognitively normal participants (mean age 70.32 years) underwent MRI and dietary assessments. Results showed that individuals who frequently eat alone...
Deciphering the timing and impact of life-extending interventions: temporal efficacy profiler distinguishes early, midlife, and senescence phase efficacies
A growing number of compounds are reported to extend lifespan, but it remains unclear whether they reduce mortality across the entire life course or only at specific ages. This uncertainty persists because the commonly used log-rank test cannot detect age-specific effects. Here, we introduce a new analytical method that addresses this limitation by revealing when, how long, and to what extent interventions alter mortality risk. Applied to survival data from 42 compounds tested in mice by the...
The Vatican City Declaration on Global Aging advocates advancing inclusive and productive futures for all
No abstract
Senescent Fibroblasts Drive Melanoma Progression Through GCP-2 Induced CREB Phosphorylation Enhancing Glycolysis
Aging constitutes the largest risk factor for melanoma progression. While a contribution of factors secreted from senescent skin fibroblasts to the progression of melanoma has been proposed, the nature of such factors and subsequent underlying mechanisms remains elusive. Here we show that the chemokine GCP-2 is excessively released by senescent fibroblasts in vitro and the skin of old melanoma patients. GCP-2 regulates, via phosphorylation of the transcription factor CREB at serine 133,...