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Stereological sampling-based estimates of dopaminergic and cholinergic neuron numbers in young adult and aged male and female Fischer 344 × Brown Norway F1 hybrid rats
Age is the primary risk factor for neurodegenerative disorders such as Parkinson's disease and Alzheimer's disease, which are characterized by profound loss of midbrain dopaminergic neurons and basal forebrain cholinergic neurons, respectively. In addition, loss of these neurons can occur even in "normal" (i.e., non-pathological) aging, and as a result there is growing recognition of the value of aged animals in studying both normal aging and age-related neurodegenerative disease. The Fischer...
Role of Sociodemographic Variables in the Association Between Physical Performance and Balance Disorders in Older Adults
CONCLUSION: Physical performance impairment is strongly associated with balance disorders among older adults, and this relationship is influenced by sociodemographic factors. These findings suggest that sociodemographic characteristics should be considered when evaluating the relationship between physical performance and balance disorders in older adults.
Daily briefing: ‘Too hot to sleep’ is harmful to your health
NIH proposes major revamp of how it scores research grant proposals
A revolutionary stem-cell therapy must proceed responsibly to achieve its full potential
Five ways 3D printing is improving lab work
Mathematics holds the secret to ‘ladder-proof’ knitting
Will you be wearing an exoskeleton in ten years? The tech that could change how we move
How to get the most out of an informational interview
Scientific expedition makes the best of bad weather
How the Middle East can become a hub for sustainable aviation fuels
Asia’s longevity gains must be translated into better health
Europe must adapt to live with megafires
Treat biological databases as infrastructure, not projects
Heatwaves expose weak links in food systems
Medieval Europe was battered with 16 catastrophic floods in just 2 years
The intense deluges, never before documented, represent the highest number of back-to-back extreme weather events in the past 700 years
NIH lifts ban on funding research in South Africa
Researchers who study HIV, tuberculosis, and other infectious disease in the country welcome policy change
A therapy that “rewrites” childhood memories can ease fear of failure
Childhood criticism can leave people carrying a fear of failure long into adulthood, but new research suggests those emotional patterns may be surprisingly flexible. Young adults who revisited painful memories through imagery-based therapy showed lasting reductions in fear, guilt, sadness, and stress.
Kratom poison center cases have surged 6,500% in the U.S.
Kratom use and serious health problems linked to it have risen dramatically across the United States over the past decade. Poison center reports jumped from just 19 cases in 2010 to more than 1,200 in 2023, while severe outcomes—including life-threatening complications, disability, and death—also climbed sharply. Researchers warn that kratom can trigger seizures, abnormal heart rhythms, liver damage, and breathing problems, with risks potentially increasing when it is combined with other drugs.
The bacteria that make cheese taste so good may also benefit your gut
Scientists studying three artisan British cheeses found that the microbes responsible for their distinctive flavors may also offer surprising benefits for gut health. As the cheeses matured, helpful bacteria transformed their aromas and textures while potentially producing compounds linked to reduced inflammation, cholesterol regulation, and appetite control.