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Alzheimer's disease causes progressive cognitive decline, yet some individuals remain resilient despite developing hallmark pathology. A subset of people with Down syndrome (DS), the most common genetic cause of Alzheimer's disease, demonstrates such resilience. Given the elevated risk of hematopoietic mutations in DS, we hypothesize that certain variants may confer microglial resilience. Here, we introduce a myeloid DS-linked CSF2RB A455D mutation into human pluripotent stem cell-derived...

Biomechanical alterations contribute to the decreased regenerative capacity of hematopoietic stem cells (HSCs) upon aging. RhoA is a key regulator of mechanosignaling, but its role in mechanotransduction in stem cell aging remains unclear. Here we show that murine HSCs respond to increased nuclear envelope (NE) tension by inducing NE translocation of P-cPLA2, which cell-intrinsically activates RhoA. Aged HSCs experience physiologically higher intrinsic NE tension, but reducing RhoA activity...

CONCLUSIONS: Unexpected stopping highlights age-related changes in movement strategy. Older adults shift from a distal-driven braking to proximal, multi-joint co-contraction strategy, characterized by increased hip work, reduced knee work, and greater muscle synergy complexity. This proximal engagement reflects a tradeoff along the stability-efficiency continuum: it enhances safety but increases metabolic cost and postural sway. By disrupting the distal-to-proximal control sequence, this...

Aging and diabetes mellitus (DM) are associated with declines in physical fitness, such as reduced muscle strength, balance, and flexibility, increasing the risk of falls and functional limitations. This pilot study used a quasi-experimental design with pre- and post-intervention assessments to evaluate the effects of a 6-month sensorimotor training (SMT) program on physical fitness in older women with type 2 diabetes. Ten women aged 65 and older were divided into an intervention group (IG, n =...

CONCLUSION: Our study reveals volatility in case numbers post-SARS-CoV-2, with males disproportionately affected. A high proportion of elderly patients take anticoagulants. Among the injured, there is a high rate with cerebral injury. Most fractures occur in exposed facial regions. Ongoing surveillance is essential to address increasing geriatric vulnerability.

CONCLUSIONS: Older adults' perceptions of health-promoting activities were influenced by personal, inter-personal and environmental factors. Contextualizing lifestyle modification programs that address their preferences and real-life situations may facilitate engagement. Older adults may also benefit from future initiatives that empower them to choose among feasible options to increase their self-efficacy for preventing frailty.

CONCLUSIONS: The results of the concept analysis of relocation in older adults revealed a comprehensive insight into this concept. Successful relocation in the older adults is achieved by considering the physical, personal, social, economic, and psychological aspects, and the preparation and planning of the older adults.

Nation was first to legally protect frozen landscapes, a key source of water