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Centuries of strain had built up on faults in the region, making them overdue for a major rupture

Analysis of 90 missions suggests midpriced spacecraft produce the most science per dollar

Advance nearly doubles chip density, but also highlights the challenge of sustaining historic trend

Springer Nature has removed two studies by Max Planck. A bot may be to blame

Vitamin B12 is needed in microscopic amounts, but a shortage can have major effects on health and energy. The vitamin was first linked to a lifesaving liver treatment for pernicious anemia nearly 100 years ago. Today, researchers are finding that B12 may also help keep cellular powerhouses called mitochondria functioning properly. This could explain why some people experience fatigue and brain fog even before traditional signs of deficiency show up.

Researchers found that a rare liver cancer evades immunotherapy by luring immune T cells away from the tumor and trapping them in nearby fibrous tissue. An FDA-approved drug called AMD3100 freed those T cells to attack the cancer, significantly improving the effectiveness of immunotherapy in tumor samples.

How does a single cell build a brain with billions of precisely organized neurons? Researchers suggest that brain cells use their lineage—their cellular family tree—as a kind of positional map. Cells that come from the same ancestor stay near one another, helping the brain organize itself without relying solely on chemical signals.

Healthy older adults experienced measurable improvements in memory, physical performance, and stress after taking placebo pills for just three weeks. The most surprising finding was that the placebo often worked even when participants knew the pills were completely inactive.

CONCLUSION: Early PD + pRBD exhibit specific and more severe neurofunctional network impairment pattern. Characterized by more significantly disrupted neurofunctional network topology and widespread functional connectivity abnormalities across multiple brain networks, with potential functional network reorganization. These functioning abnormalities may serve as imaging biomarkers for this clinically malignant subtype and provide potential neurobiological mechanism for understanding its poorer...

Bisphenol-A (BPA), a ubiquitous component of polycarbonate plastics and epoxy resins, has emerged as a significant environmental risk factor for neurodegenerative diseases, particularly Alzheimer's disease (AD). It is widely detected in the environment and humans due to its extensive use in plastics and epoxy resins for consumer products such as bottles, containers, and tableware. This review synthesizes current evidence on the molecular and cellular mechanisms by which BPA exposure may...

Parkinson's disease (PD) is a progressive neurodegenerative disorder characterized by dopaminergic neuronal loss and the accumulation of α-synuclein-containing Lewy bodies. Growing evidence indicates that neuroinflammation, particularly through the activation of Toll-like receptors (TLRs), contributes significantly to PD pathogenesis. TLRs, particularly TLR2 and TLR4, detect endogenous damage-associated molecular patterns such as misfolded α-synuclein. This recognition initiates signaling...