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Bst2-targeted senotherapy restores visual function by eliminating senescent retinal cells
Senescent cells contribute to degenerative processes in multiple tissues, including the retina. In the retinal pigment epithelium (RPE), their accumulation is closely associated with retinal aging and disease progression. Eliminating senescent RPE cells has shown therapeutic potential, but conventional senolytics often lack the specificity required to spare non-senescent cells, raising safety concerns. To overcome this, we performed integrated transcriptomic analyses of male mouse-derived RPE...
Avoidance of rejuvenation: a stress test for evolutionary theories of aging
The biological feasibility of human rejuvenation remains a subject of intense debate, yet answering this question is critical for guiding research strategies. Should aging research focus only on reversing aging in older individuals, or pausing its progression at mid-ages, be more accessible? Here, we attempt to address this question with evolutionary biology. Rejuvenation occurs in a few species, and, paradoxically, is typically induced by stress but not used under optimal conditions. Using...
Thymic health consequences in adults
The thymus is essential for establishing T cell diversity early in life, but undergoes profound involution with age and has therefore traditionally been regarded as largely nonfunctional in adults^(1,2). Here we propose that preserving thymic functionality is integral to adult health and longevity. We developed a deep learning framework to quantify thymic health from routine radiographic images and evaluated its association with longevity and risk of major age-associated diseases in two large...
Barriers and facilitators to rehabilitation exercise adherence in older adults with hip fractures: a mixed-methods systematic review
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The role of sleep disorders in the motoric and cognitive trajectories of older physically frail sarcopenic and healthy active subjects: SOMNUS-DARE, a prospective cohort study
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Daily briefing: Static electricity is still a mystery — here’s what we know
Stress can cause eczema to flare up – now we know why
Strength persists after a mid-life course of obesity drugs
Faster ticking of ‘biological clock’ predicts shorter lifespan
<i>Project Hail Mary</i> film builds dazzling new worlds — and grounds them in science
A breath of fresh air: solving Ulaanbaatar’s pollution issues — in photos
China could be the world’s biggest public funder of science within two years
Editorial Expression of Concern: A FADD-dependent innate immune mechanism in mammalian cells
Agentic AI and the next intelligence explosion
Science, Volume 391, Issue 6791, March 2026.
Erratum for the Research Article “Complex mesoscale landscapes beneath Antarctica mapped from space”
Science, Volume 391, Issue 6791, March 2026.
Erratum for the Research Article “How do social media feed algorithms affect attitudes and behavior in an election campaign?”
Science, Volume 391, Issue 6791, March 2026.
Spatial and morphological organization of mitochondria in neurons across a connectome
Science, Volume 391, Issue 6791, March 2026.
Hypothalamic clock governs circadian pain
Science, Volume 391, Issue 6791, March 2026.
Live-cell single-molecule dynamics of eukaryotic RNA polymerase machineries
Science, Volume 391, Issue 6791, March 2026.
Highly efficient, deep-ultraviolet luminescence in hBN moiré quantum wells
Science, Volume 391, Issue 6791, March 2026.