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Researchers discovered that declining levels of phosphatidylcholine may be a major cause of age-related mitochondrial dysfunction and loss of cellular energy. Remarkably, boosting this nutrient restored more youthful mitochondrial performance in aging organisms, suggesting some aspects of aging can be slowed or reversed.

Science, Ahead of Print.

Science, Ahead of Print.

The government has tasked a group of scientists with assessing new technologies for “sustainable” oil and gas drilling—but many experts say it’s a fantasy

Understanding how the first patient became infected may shed new light on Andes virus’ transmission patterns and incubation period

Goblin sharks have never before been filmed in their natural habitat

Enhanced cryo–electron microscopy promises to bring previously elusive proteins into view

Studies of the Atlantic's circulation find signs of both weakening and unexpected stability in the face of global warming

Cancer cells often survive treatment by fixing the DNA damage that therapy is meant to cause. Researchers found that UNI418 can disrupt this repair ability, leaving cancer cells more exposed. When combined with a PARP inhibitor, it helped resistant cancer cells respond to treatment again. The findings point to a new strategy for overcoming cancer drug resistance.

NIH programs and leadership are hit especially hard, while other science agencies are barely mentioned

Stretching 1200 kilometers, the unusual collection of carcasses includes fossils older than 5 million years

Researchers gave top AI models a classic attention test used in psychology and found a major flaw. While the models could correctly name colors in short lists, their performance deteriorated sharply as the task became longer and more complex. Some leading systems fell from over 90% accuracy to nearly complete failure.

A groundbreaking new connectome maps every neural connection in an adult fruit fly’s central nervous system, creating an unprecedented view of how the brain and body work together. The findings suggest that complex behaviors emerge from distributed local circuits rather than a single central controller, offering new clues about intelligence, movement, and brain function.

Alzheimer's disease (AD), characterized by progressive cognitive decline, represents a major public health challenge in aging societies. Since the proposal of the amyloid cascade hypothesis, Aβ-targeted therapeutic strategies have dominated this field for over three decades. Although recent anti-Aβ antibodies have shown modest promise, their limited clinical benefits coupled with safety concerns underscore the necessity of re-evaluating the pathological mechanisms underlying AD. Cerebral...