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When science becomes personal
Science, Volume 391, Issue 6791, Page 1290-1290, March 2026.
Global cases of groundwater recovery after interventions
Science, Volume 391, Issue 6791, Page 1218-1228, March 2026.
Higher carbon storage in primary than secondary boreal forests in Sweden
Science, Volume 391, Issue 6791, Page 1256-1261, March 2026.
A sympathetic-eosinophil axis orchestrates psychological stress to exacerbate skin inflammation
Science, Volume 391, Issue 6791, Page 1269-1277, March 2026.
A mid-Holocene age for Monte Verde challenges the timeline of human colonization of South America
Science, Volume 391, Issue 6791, Page 1283-1288, March 2026.
Cross- and branched-selective hydroalkenylation by metal hydride selection
Science, Volume 391, Issue 6791, Page 1262-1268, March 2026.
Humans share acoustic preferences with other animals
Science, Volume 391, Issue 6791, Page 1246-1249, March 2026.
Host-derived nitrate fuels indole production by Escherichia coli to drive chronic kidney disease progression
Science, Volume 391, Issue 6791, Page 1250-1255, March 2026.
Paleomagnetic detection of relative plate motions and an infrequently reversing core dynamo at 3.5 Ga
Science, Volume 391, Issue 6791, Page 1278-1282, March 2026.
Resetting of a tandem microRNA156 enables vegetative perennial growth in rice
Science, Volume 391, Issue 6791, Page 1239-1245, March 2026.
Genes enter the garden of good and evil
Science, Volume 391, Issue 6791, Page 1214-1214, March 2026.
Self-serving “tweaks” hurt science
Science, Volume 391, Issue 6791, Page 1213-1213, March 2026.
How realistic is the science in <em>Project Hail Mary</em>?
From the viability of waterless life to how researchers should handle cosmic emergencies, astronomer Wendy Freedman weighs in on the new sci-fi film
Debate explodes over age of key South American archaeological site
New study argues Monte Verde is far younger than once thought, challenging when people arrived in the Americas
Rice needs to be replanted every year. Genetic tinkering could make it more like apples
Researchers re-create key aspects of long-lived wild relative, which could make rice fields longer lasting
What happened when an Arab neuroscientist took the helm at an Israeli university?
Mouna Maroun’s stewardship highlights the promise—and perils—of reconciliation through science
Mysterious type of static electricity has a hidden culprit
Find explains how volcanic ash plumes spark lightning and why dust in grain silos can explode
Mitochondria packaged in blood cell membranes improve disease symptoms in mice
Tiny capsules can deliver healthy organelles into animals with Parkinson’s-like and other mitochondria-linked disorders
Blood-brain barrier-penetrative lipid nanoparticles enable systemic delivery of TRIM11 mRNA to disaggregate Tau in Alzheimer's disease models
Hyperphosphorylated Tau aggregates are a central pathological hallmark of Alzheimer's disease (AD), yet no approved therapy directly targets this process. mRNA therapeutics provide a transient and non-viral option but are limited by the blood-brain barrier (BBB). TRIM11 is an ATP-independent disaggregase that dissolves pathological Tau fibrils and promotes proteasomal clearance. Here, a ligand-free lipid nanoparticle (PLNP) is developed with zwitterionic, acetylcholine-mimetic...
TET CpG sequence-context-specific DNA demethylation shapes progression of IDH-mutant gliomas
Treatment decisions in IDH-mutant oligodendrogliomas are shaped by tumor aggressiveness, underscoring the need for objective grading of these malignant brain tumors. We collect 302 primary and recurrent resections from oligodendrogliomas and perform Ki-67 staining, proteomics, and DNA methylation profiling. During tumor progression, DNA methylation of oligodendrogliomas changes along a continuum. This continuum is linked to increased epigenetic aging, methylation of transcription factors and...