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Age-related and noise-induced hearing loss reflect progressive cochlear degeneration and adaptive changes in central auditory pathways, yet their joint effects on auditory brainstem response (ABR) amplitudes and auditory thresholds remain unclear. We developed the Auditory Homeostatic Dynamics Model (AHDM), a three-state ordinary differential equation model of hair-cell sensory function, cochlear synaptic integrity, and activity-dependent central compensation across low-, mid-, and...

Persistent low-grade inflammation, oxidative stress, cellular senescence, and disturbance of cellular homeostasis are all connected with ageing and can lead to the development of age-related diseases. Ferroptosis, an iron-dependent type of controlled cell death, has been linked to these processes more and more. It may represent a key connection between inflammation, oxidative damage, and tissue failure as people age. With a focus on neurodegenerative, cardiovascular, metabolic, pulmonary, and...

CONCLUSION: Health literacy is a key factor of active and successful ageing. To promote active ageing, older adults care centres should prioritise health literacy.

Engineered fluids could extract metals from fracked reservoirs, supplying materials for solar cells and electric vehicles

People with depression who dramatically cut ultra-processed foods experienced notable improvements in their symptoms in a small preliminary study. Researchers suspect healthier eating may benefit the brain partly by reducing gut damage and chronic inflammation.

Science, Ahead of Print.

The Alzheimer’s risk gene APOE4 may actively damage brain blood vessels and sabotage the cellular systems that remove harmful proteins. Researchers were able to reverse some of these effects in experiments, revealing promising new targets for Alzheimer’s, Parkinson’s, and other neurodegenerative diseases.

Experimental reactor needed much more uranium and heavy water than the country could muster

A common mistake during blood pressure checks could make readings appear substantially higher than they really are. Johns Hopkins researchers found that leaving the arm unsupported can raise systolic readings by about 6.5 mmHg, potentially affecting a hypertension diagnosis.

Shifts in blood proteins could point to ways to fight menopause “brain fog” and prevent later dementia

Companies striving to reduce continent’s reliance on foreign shots must overcome major financial and logistical challenges

A review of more than 265,000 people found that cannabis use was associated with higher rates of both committing violence and becoming a victim of it. The researchers say the link is significant but does not prove cannabis itself is the cause.