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Associations Between 40-Year Trajectories of BMI and Proteomic and Epigenetic Aging Clocks: Deciphering Nonlinearity and Interactions
The potential of proteomic aging clocks for obesity research, and the extent of nonlinearity in longitudinal associations between body weight and biological aging, remain underexplored. We investigated how BMI at ages 18 and ~60, as well as changes in BMI from age 18 to ~60, relate to downstream epigenetic and proteomic aging. We also examined nonlinearity and interactions in these associations. Analyses were conducted in 401 Finnish twins with up to nine self-reported or measured BMI values...
The aggregate proteome of Caenorhabditis elegans mitochondria implicates shared mechanisms of aging and Alzheimer's disease
CONCLUSION: These findings place mitochondrial proteome collapse at the center of aging and AD-seeded pathology, distinguish Aβ- and Tau-driven proteotoxic routes, and nominate a conserved panel of aggregation-prone proteins as mechanistic drivers and candidate biomarkers for early detection and intervention in AD.
Daily briefing: Brain–immune crosstalk worsens the damage of heart attacks
48 hours without lungs: artificial organ kept man alive until transplant
Still conscious? Brain marker signals when anaesthesia takes hold
Genetically engineered ‘stinkweed’ comes up roses for making seed oil
Longevity is in the genes: half of lifespan is heritable
Author Correction: Hunter-gatherer sea voyages extended to remotest Mediterranean islands
The ‘undone science’ of opioid overdose deaths
Science, Volume 391, Issue 6784, January 2026.
The origin of hepatocellular carcinoma depends on metabolic zonation
Science, Volume 391, Issue 6784, January 2026.
Wafer-scale ultrathin and uniform van der Waals ferroelectric oxide
Science, Volume 391, Issue 6784, January 2026.
High-precision tracking of human foragers reveals adaptive social information use in the wild
Science, Volume 391, Issue 6784, January 2026.
DNA-protein cross-links promote cGAS-STING–driven premature aging and embryonic lethality
Science, Volume 391, Issue 6784, January 2026.
The evolution of gene regulation in mammalian cerebellum development
Science, Volume 391, Issue 6784, January 2026.
Engineered aldehyde dehydrogenases for amide bond formation
Science, Volume 391, Issue 6784, January 2026.
Aging drives a program of DNA methylation decay in plant organs
Science, Volume 391, Issue 6784, January 2026.