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The autistic brain processes faces differently than scientists thought

2 weeks ago
A major new study reveals that autistic children’s brains process faces differently, and those differences may begin earlier than scientists previously thought. Researchers found that brain signals associated with recognizing faces become more specialized as neurotypical children grow older, but show much less change in autistic children. The discovery could help explain why some autistic people have difficulty recognizing faces and reading emotions.

Scientists discover the immune system’s hidden sense of touch

2 weeks ago
Scientists at McGill University have discovered a surprising new ability of immune cells that could change how we understand long-term immunity. Researchers found that T cells can actually sense how stiff their surrounding tissues are, using these physical signals to help determine whether they develop into long-lasting memory cells that protect against future infections.

The secret to slower aging may be hiding in your gut

2 weeks 1 day ago
The secret to aging more slowly may be hiding in your gut. Scientists discovered that certain gut bacteria are strongly linked to how quickly the body ages, with microbial differences accounting for about 15% of the variation in biological aging rates. Some bacterial species were associated with slower aging, while others were linked to accelerated aging.

Common drugs may help dangerous viruses spread through the body

2 weeks 1 day ago
A surprising discovery reveals that widely used anti-inflammatory drugs may unintentionally help dangerous viruses spread through the body. Scientists found that JAK inhibitors, prescribed for rheumatoid arthritis and other inflammatory diseases, can weaken a crucial immune defense against influenza, COVID-19, and other infections. By suppressing genes that normally fight viruses, these medications may leave patients more vulnerable to infection.

The use of biological age and artificial intelligence in health care

2 weeks 1 day ago
This commentary highlights the age illusion and advocates integrating biological age and artificial intelligence (AI) to enhance clinical precision in health care. By synthesizing geroscience and machine learning, practitioners and scientists can effectively bridge the gap between experimental biomarkers and personalized medicine and longevity care. This contribution is timely as the importance of biological age and predictive analytics offer transformative potential for diagnostics while...
Pawel Kordowitzki

Survey of the human proteostasis network: translation, protein folding, and organelle-specific systems

2 weeks 1 day ago
The condition of having a healthy, functional proteome is known as protein homeostasis, or proteostasis. Maintaining proteostasis is the province of the proteostasis network, which consists of the cellular components that regulate protein synthesis, folding, localization, and degradation. The proteostasis network is a fundamental functional unit in biology with relevance to many diseases. Despite its importance, the human proteostasis network has until now lacked a precise definition, limiting...
Evan T Powers

Trait-linked brainstem circuit resilience balances tau pathology-induced cellular vulnerability in Alzheimer's disease

2 weeks 1 day ago
Although tau pathology correlates with cognitive decline in Alzheimer's disease (AD), some individuals exhibit resilience by maintaining cognitive function. The mechanisms enabling this protection, particularly before widespread cortical degeneration occurs, remain elusive. Here, we identify a dynamic interplay between cellular vulnerability and circuit-level resilience that shapes cognitive outcomes in AD. Tau accumulation in the Edinger-Westphal nucleus (EW) impairs attention by inducing...
Jie-Qun Zheng

A Longitudinal Study on Social Isolation, Chronic Diseases, and Depressive Symptoms: Evidence From the Korean Longitudinal Study of Aging

2 weeks 1 day ago
ObjectiveThis study examined the longitudinal effects of social isolation on chronic diseases and depressive symptoms among middle-aged and older adults in South Korea, with attention to gender and age differences.MethodUsing data from three waves of the Korean Longitudinal Study of Aging, longitudinal path analysis was conducted on 5,585 participants.ResultsWomen and older adults showed higher levels of social isolation, chronic diseases, and depressive symptoms, indicating greater...
Soondool Chung