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Science, Volume 391, Issue 6789, Page 1078-1078, March 2026.

Science, Volume 391, Issue 6789, Page 1070-1075, March 2026.

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Science, Volume 391, Issue 6789, Page 1063-1069, March 2026.

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Science, Volume 391, Issue 6789, Page 978-984, March 2026.

New method for visualizing organisms opens the door for mass digitization efforts

Inspired by the loss of their mother, they have poured millions into studying a key protein behind frontotemporal dementia. But all has not gone according to plan

Strategy gains momentum after promising results in cell studies and infected people

No abstract

Parkinson's disease (PD) is a prevalent neurodegenerative disorder predominantly affecting individuals over 60. Its motor symptoms stem from the deterioration of dopaminergic neurons within the substantia nigra. Despite aging being a significant risk factor, the specific mechanisms linking aging and PD pathology remain unclear. Leveraging advancements in single-cell genomics, this study utilizes single-nucleus multiome sequencing to capture transcriptomic and epigenetic profiles from 40,125...

Population ageing has widened the gap between lifespan and healthspan, with frailty and functional dependence increasingly shaping late-life outcomes. Yet trajectories in older age remain highly heterogeneous, suggesting that vulnerability is not determined by chronological age alone but by differences in adaptive capacity. This review reframes resilience as a dynamic, multilevel construct linking molecular maintenance, regulation within the immune-endocrine-autonomic "vital systems triad," and...

Metastasis is the major cause of death for patients with triple-negative breast cancer and other solid malignancies. Metastases arise from cancer cells that disseminate from the original tumour, survive systemic immune surveillance and colonize new organs¹. Little is known about how initial disseminated tumour cells (DTCs) overcome anti-tumour immunity after seeding a new organ. Here we use a visible antigen in a model of triple-negative breast cancer with cognate CD8^(+) T cells to study the...

No abstract

The reduction in number and decreased differentiation capacity of oligodendrocyte progenitor cells (OPCs) directly affect myelination in demyelinating diseases and aging, but the underlying mechanisms remain incompletely characterized. Here we observed a marked decline in the number of OPCs during aging, notably within the subpopulation highly expressing Acss2, which encodes acetyl-CoA synthetase 2 (ACSS2). Deletion of ACSS2 in the oligodendrocyte lineage resulted in a reduced OPC population,...

To identify the pattern of cortical atrophy variation in Parkinson's disease (PD) and its contribution to clinical manifestations beyond dopaminergic dysfunction, 45 healthy controls (HCs) underwent MRI, and 222 participants with PD additionally underwent dopamine transporter (DAT)-PET, Unified PD Rating Scale (UPDRS), and neuropsychological tests. Using principal component analysis in PD, a single pattern in cortical thickness (PC1^(PD)) was identified. Linear regressions models were applied to...

Parkinson's disease (PD) is a prevalent neurodegenerative disorder predominantly affecting individuals over 60. Its motor symptoms stem from the deterioration of dopaminergic neurons within the substantia nigra. Despite aging being a significant risk factor, the specific mechanisms linking aging and PD pathology remain unclear. Leveraging advancements in single-cell genomics, this study utilizes single-nucleus multiome sequencing to capture transcriptomic and epigenetic profiles from 40,125...