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Giant balloon gives rise to new view of the Milky Way’s centre
Pre-clinical data interpretation requires clinical context
Reply to: Pre-clinical data interpretation requires clinical context
Lead carboxylates passivation for meter-scale perovskite solar modules
Three-dimensional mapping of intact ovaries reveals the aging dynamics of the ovarian reserve
A particle made of force: physicists say they’ve found mysterious ‘glueball’
System lag
A controversial Alzheimer’s surgery is said to reverse symptoms — here’s what scientists know
Were these ancient rock images painted with human blood?
Macabre ingredient may have helped murals on Chinese cliffs survive nearly 2000 years of weathering
Can a new, safer class of pain drugs ever rival opioids?
Sodium channel blockers promise relief without addiction risk. But it’s been a challenge to improve them
Denisovans towered over their contemporaries and munched a bunch of meat
A pair of studies dissects the stature and diets of our mysterious archaic cousins
Hundreds of paper-mill papers peddled in ads were later published
More than one-fifth of some IEEE conferences’ papers appear linked to authorship for sale
MIT neuroscientists discover the brain can reason without words
MIT neuroscientists have found striking evidence that language and logical reasoning are powered by separate systems in the brain. Even people with severe language impairments caused by stroke were able to solve challenging logic puzzles as well as people without those impairments, while brain scans showed that language-processing regions stayed largely quiet during reasoning tasks.
Marine heatwaves are harming human health in surprising ways
Marine heatwaves are emerging as a threat not just to coral reefs and fisheries, but to human health and well-being. Researchers warn that unusually hot oceans can fuel stronger storms, trigger harmful algal blooms, reduce seafood supplies, disrupt livelihoods, and contribute to anxiety, grief, and depression in coastal communities.
Newly discovered virus is sickening cattle in Western Europe
The pathogen, which reduces milk production, is the latest midge-transmitted virus affecting ruminants to reach the continent
Immune surveillance and immune evasion of senescent cells
Senescence, which is defined as a state of stable cell cycle arrest, can occur in all tissues of the body. The surveillance and clearance of senescent cells by the immune system is necessary for tissue homeostasis; when this immune surveillance does not occur efficiently, for example, during tumorigenesis and ageing, it has pathological consequences. For example, if the immune clearance of senescent cells is evaded, such as through recruitment of immunosuppressive cells, expression of immune...
Isoorientin attenuates aging-induced bone deterioration by suppressing M1-mediated TLR4-MAPK-NF-kappaB inflammatory signaling
CONCLUSION: Isoorientin alleviates age-related bone loss by suppressing TLR4-mediated inflammation, reducing osteoclast activation, and restoring impaired osteogenesis. These findings identify isoorientin as a promising therapeutic candidate for age-associated osteoporosis.
Anti-aging interventions need less hype and more clinical evidence
No abstract
TNFR1 signaling connects inflammation to impaired fatty acid oxidation to drive intestinal stem cell aging
Aging is characterized by a decline in function of intestinal stem cells (ISCs), but the extent to which this is shaped by systemic factors is unclear. Here we show that the ISC aging phenotype can be propagated from old to young mice utilizing heterochronic parabiosis, and implicate a role for inflammation in these effects, as anti-inflammatory drugs, including TNF antibodies, restored function. Parabiotic rescue experiments demonstrate that TNFR1 knockout protected young ISCs from the old...
Breathing new life into the rational design of Alzheimer's therapeutics
No abstract