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Protein Tyrosine Phosphatase 1B-Mediated Granulosa Cell Insulin Resistance Links Metabolic Stress to Aging-Relevant Ovarian Dysfunction and Is Reversed by Gengnianchun
Metabolic disorders, particularly insulin resistance, are increasingly recognized as accelerators of female reproductive decline. However, the molecular mechanisms by which peripheral metabolic stress translates into impaired ovarian reserve remain incompletely understood. Here, we propose that protein tyrosine phosphatase 1B (PTP1B), a negative regulator of insulin signaling, serves as a molecular bridge linking systemic insulin resistance to aging-relevant ovarian dysfunction and can be...
Treg-microglia crosstalk in Alzheimer's disease: stage-dependent dynamics, molecular mechanisms, and translational challenge
Alzheimer's disease (AD) is characterized by amyloid-beta (Aβ) deposition, tau hyperphosphorylation, and chronic neuroinflammation. Emerging evidence from preclinical models suggests that aberrant immune crosstalk between regulatory T cells (Tregs) and microglia may contribute to disease progression, though its precise role in human AD remains to be fully elucidated. In rodent models, Tregs have been shown to cross the blood-brain barrier and, through cell-contact-dependent mechanisms and...
Editorial: Mitochondrial dysfunction in cellular and molecular mechanisms of brain aging
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Correction to "Senescence-Driven Remodeling Defines an Aggressive and Immunomodulatory Subtype of Endometriosis"
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This scientist is rethinking how to put GPS collars on wildlife
Richard Bischof’s devices aim to make telemetry research cheaper, higher quality, and more humane