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Intracortical microstimulation (ICMS) of somatosensory cortex can restore a sense of touch to people with spinal cord injury. In this early feasibility clinical trial (NCT01894802), we evaluated the safety, efficacy, and longevity of ICMS because there is a paucity of such long-term studies in humans. This information is crucial to the development of clinical neuromodulation devices, particularly for restoring touch, hearing, and vision. ICMS was delivered to five participants with spinal cord...

Brain age estimation using machine learning has gained significant attention as a promising approach to assess cognitive health and aging. By analyzing structural and functional MRI data, these models can predict an individual's brain age, providing insights into neurological conditions and potential interventions. The purpose of this study is to compare the performance of different MRI modalities in predicting brain age and to determine the relative importance of specific brain regions. In this...

Microglia maintain neuronal homeostasis through dynamic surveillance strategies that depend on their functional state. In the healthy brain, highly ramified microglia monitor neuronal integrity via motile processes and transient soma contacts. Aging is associated with reduced process motility and diminished expression of homeostatic markers, raising the question of how microglial surveillance adapts to these changes. Here, we used ex vivo time-lapse imaging of acute cortical slices from young...