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This narrative review discusses the relationship between structural changes in the skin and mitochondrial function during aging and evaluates emerging therapeutic interventions targeting mitochondrial dysfunction. An analysis of 49 scientific articles published between 2015 and 2025 was conducted using descriptors including "skin aging," "mitochondrial dysfunction," "oxidative stress," and "cutaneous senescence," and articles were retrieved from PubMed, Scopus, and ScienceDirect. Additional...

CONCLUSIONS: This study highlights the complex web of interrelations linking dementia with social, behavioural, and health-related factors in later life. Rather than implying causal direction, these findings illustrate how multiple factors cluster and coexist within older adults' lives. These interconnections may inform the design of holistic strategies that integrate employment opportunities, physical activity promotion, social participation, sleep health, and cerebrovascular prevention into...

CONCLUSION: Cognitive decline over four years was associated with an increased risk of mortality among older women. Further studies should explore whether declines earlier in life or among men are also associated with an increased risk of mortality.

Scientists analyzing the genomes of thousands of people across Japan discovered evidence for a previously overlooked third ancestral group, challenging the long-accepted “dual origins” theory. The newly identified ancestry appears linked to the ancient Emishi people of northeastern Japan. Researchers also uncovered inherited Neanderthal and Denisovan DNA connected to conditions like diabetes, heart disease, and cancer.

The National Science Board urges robust response to China’s rise in cover letter to its biennial report on the global research enterprise

Alejandro Arteaga’s efforts to identify and protect tropical reptiles and amphibians have entangled him in controversy

UC Davis researchers created brand-new psychedelic-like compounds by shining UV light on amino acid-based molecules. These compounds activated key serotonin receptors tied to brain plasticity and mental health benefits, but surprisingly did not cause hallucination-like behavior in animal tests. Scientists say the discovery could lead to future treatments for depression, PTSD, and addiction without the intense psychedelic experience.

Ancient Homo erectus teeth from China yield protein variants seen in Denisovans—and us