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HIV-1 signalling remodels nuclear pores to licence infection
Predicting temporal stability and resilience from resistance and recovery
Purcell-enhanced spin–phonon coupling with a single colour centre
Steric hindrance of antibody binding in an Omicron spike fusion intermediate
Prefrontal to ventral tegmental area dynamics drive contingency degradation
Tree community resource economics control soil food web multifunctionality
Plasticity and language in the anaesthetized human hippocampus
Non-invasive profiling of the tumour microenvironment with spatial ecotypes
Foreshock-induced slip transients set mainshock nucleation timing
Electrocaloric effects across room temperature in multilayer capacitors
Pollinators support the nutrition and income of vulnerable communities
RNA-triggered cell killing with CRISPR–Cas12a2
Expanding the human proteome with microproteins and peptideins
Two-qubit logic and teleportation with mobile spin qubits in silicon
Anaesthetized brains can still process podcasts
Author Correction: Multidimensional profiling of heterogeneity in supratentorial ependymomas
Are attention spans really shrinking? What the science says
Colon cancer breakthrough keeps patients cancer-free for nearly 3 years
A short burst of immunotherapy before surgery is delivering surprisingly powerful results for a specific type of colorectal cancer. Patients in a UK-led trial who received just nine weeks of pembrolizumab prior to surgery have remained cancer-free nearly three years later—an outcome that challenges the standard approach of surgery followed by months of chemotherapy.
Common knee surgery found ineffective, may make things worse
A major 10-year clinical trial is turning one of the world’s most common knee surgeries on its head. Researchers found that trimming a damaged meniscus—a procedure long believed to relieve pain—offers no real benefit over placebo surgery. Even more surprising, patients who had the operation actually fared worse over time, with more symptoms, poorer function, faster progression of osteoarthritis, and a greater likelihood of needing additional surgery.
AI agents may be skilled researchers—but not always honest ones
Two high-profile tools have been shown to make up data and “p-hack” their results