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In Other Journals

2 weeks 2 days ago
Science, Volume 392, Issue 6796, Page 380-381, April 2026.
Corinne Simonti, and Jesse Smith, Cheri Sirois, Sarah H. Ross, Bianca Lopez, Joana Osório, Keith T. Smith, Phil Szuromi, and Melissa McCartney

Dark discoveries

2 weeks 2 days ago
Science, Volume 392, Issue 6796, Page 363-363, April 2026.
Laura Trethewey

Somatic cancer variants enriched in Alzheimer's disease microglia-like cells drive inflammatory and proliferative states

2 weeks 3 days ago
Alzheimer's disease (AD) is a neurodegenerative condition characterized by microglia-mediated neuroinflammation. Deep (>1,000×) panel sequencing of 311 brain samples revealed enrichment of somatic single-nucleotide variants (sSNVs) in cancer driver genes in AD brains, especially in genes associated with clonal hematopoiesis (CH). These sSNVs were associated with clonal expansion and carried by both microglia-like brain macrophages (MLBMs) in multiple brain regions as well as paired blood,...
August Yue Huang