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What will be the first AI-designed drug? These disease-fighting antibodies are top contenders
A poetic ode to eddies and an earwig’s brush with death
Food will be more affordable — if we double funds for agriculture research now
What we eat is making us obese and sick — but science shows solutions are within reach
Argentina must finish building the CART radio telescope
Drug woes won’t be tamed by US price regulations
Better models are needed to gauge the ecological impacts of reservoirs
Don’t overlook the value of co-supervision in PhD training
The first patients have been helped by cancer-fighting cells made directly in their bodies
Novel approach could be faster, and cheaper, than making the cells in the lab—but safety concerns linger
Cerebral glymphatic system: Structure, regulation, ageing, and mechanisms of encephalopathy
The glymphatic system was initially considered as a perivascular channel, responsible for the clearance of substances within the brain. With the deepening comprehension of the functions of the extracellular space (ECS) and the discovery of meningeal lymphatic vessels and subarachnoid lymphatic-like membrane, it is proposed that the glymphatic system should be a complex system encompassing the perivascular space, ECS, and lymphatic-like structures, and it plays crucial roles in the delivery of...
Profiling the Braak progression in Parkinson's disease: a transcriptomics and ML driven identification of progressive biomarker and prognostic ceRNA signature
Parkinson's disease (PD), the second most prevalent neurodegenerative disorder, is marked by dopaminergic neuron loss and α-synuclein aggregation. Although Braak staging based on Lewy body pathology stratifies disease progression, clinical variability persists. Identifying stage-specific molecular signatures is essential for developing effective progressive biomarkers. Here, we integrated midbrain transcriptomic data from microarray, bulk RNA-seq, and snRNA-seq platforms. Subsequently, to...
alpha-Synuclein signatures mark Parkinson disease subtypes
No abstract
Mathematical artifacts in slope-intercept correlations invalidate biological inferences in aging research
No abstract
Cerebral glymphatic system: Structure, regulation, ageing, and mechanisms of encephalopathy
The glymphatic system was initially considered as a perivascular channel, responsible for the clearance of substances within the brain. With the deepening comprehension of the functions of the extracellular space (ECS) and the discovery of meningeal lymphatic vessels and subarachnoid lymphatic-like membrane, it is proposed that the glymphatic system should be a complex system encompassing the perivascular space, ECS, and lymphatic-like structures, and it plays crucial roles in the delivery of...
Mammo-AGE: deep learning estimation of breast age from mammograms
Biological age is an important indicator of organ functions and health. Although mammograms are widely used in breast cancer screening, the potential of mammogram-based biological age predictors remains underexplored. Here, we propose a deep learning model to estimate the biological age of the breast using healthy mammograms. The model is developed on three large datasets and externally validated on two additional datasets, encompassing 95,826 mammograms from 44,497 women aged 18 to 98 years. It...
Pharmacological activation of p53 induces dose-dependent changes in endothelial cell fate during angiogenic sprouting
The cell cycle is a key regulator of endothelial cell specification into tip and stalk cell phenotypes, which are essential for angiogenesis in both normal development and pathological conditions. While the tumor suppressor p53 is known to regulate the cell cycle and influence cell fate, its role in modulating the cell fate of these phenotypes remains unclear. Using non-genotoxic small molecule and stapled peptide compounds to pharmacologically activate p53 via MDM2 inhibition, we demonstrate...
A lifespan clock tells the biology of time
No abstract
Wearable technologies for assisted mobility in the real world
Mobility impairments from aging, injury, or medical conditions limit independence and social participation. Conventional assistive devices lack adaptability in complex environments. Recent wearable technologies integrating neural sensing, electronics, and co-design offer personalized, responsive mobility support. This perspective focuses on advances in wearable sensing and multimodal fusion for intent recognition, environmental interaction, and adaptive control in exoskeletons, prosthetics,...
Chaperone-mediated autophagy as a sex-specific modulator of synaptic proteostasis and neural function
Chaperone-mediated autophagy (CMA), once considered a secondary or auxiliary degradation pathway, is now recognized as a central regulator of synaptic proteostasis. A recent study by Khawaja et al. (2025) in Nature Cell Biology provides compelling evidence that CMA actively remodels the synaptic proteome in a sex-specific manner. Using a conditional knockout strategy based on Lamp2a-floxed mice crossed with a Camk2a-Cre driver line to achieve excitatory neuron-specific deletion of Lamp2a in...
Exercise regulates mitophagy to alleviate parkinsonian neurodegeneration
Parkinson's disease (PD) is a common neurodegenerative disorder with a rising incidence in aging populations, substantially diminishing patients' quality of life. Mitochondria are central to neuronal energy metabolism, and mitophagy plays a pivotal role in maintaining mitochondrial quality by removing damaged organelles. In PD, impaired mitophagy leads to the accumulation of dysfunctional mitochondria, exacerbating oxidative stress and bioenergetic deficits and thereby accelerating disease...