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Dynamic antigen expression and cytotoxic T cell resistance in HIV reservoir clones
Editorial Expression of Concern: Opposing roles for calcineurin and ATF3 in squamous skin cancer
Identification of distinct and shared biomarker panels in different manifestations of cerebral small-vessel disease through proteomic profiling
Senescence at the crossroads of postpartum remodeling and tumorigenesis
Scientists must step up to avert a nuclear breakout
China is waging war on Alzheimer’s. What can its approach teach the rest of the world?
Nuclear weapons testing is harmful — there’s no case for a restart
COVID’s origins: what we do and don’t know
Evidence alone won’t save biodiversity: the golden apple snail reveals an implementation gap
Account for AI in the environmental footprint of scientific publishing
Defunding Chile’s climate research will undermine science and the region
Treasures of scientific history could be hiding in plain sight
The Contributor Role Taxonomy tool must serve to record extent of authorship
Author Correction: Global subsidence of river deltas
Could dewdrops explain why plants are flowering earlier?
Water droplets set off a chemical cascade that tells a plant it’s time to blossom, new study finds
Community health project in Kenya and Uganda dramatically cuts new HIV infections
Large-scale study finds that simplifying delivery of prevention medication and improving connections to clinics is key
Major Chinese funder to stop paying fees for 30 pricey open-access journals
Move comes amid effort to grow the country’s own journals
Allegations of a Chinese nuclear blast may reignite weapons testing
As new global arms race looms, accusation highlights limits to monitoring low-yield tests
Gene therapy targeting synaptopathy linked with Alzheimer's and Parkinson's disease
Synaptic Plasticity pertains to the synapse's tendency to adapt fresh information and is a crucial step in the establishment of brain circuits that aid in memory formation. It has become one of the most intensively researched topics in all of neuroscience. Pieces of evidence are accumulating that synaptopathy (altered synaptic plasticity) mechanisms contribute to Alzheimer's disease (AD) and Parkinson's disease (PD). Toxins responsible for synaptopathy and aberrant neurotransmitter (NT) release...
How cytochrome P450 enzymes in humans are involved in Parkinson's disease: a literature review
This review synthesizes three decades of evidence regarding the role of cytochrome P450 enzymes (CYPs) in Parkinson's disease (PD), revealing their multifaceted roles beyond traditional pesticide metabolism. While CYP2D6 remains the most studied enzyme due to its association with PD risk in poor metabolizer phenotypes and its dual role in dopamine (DA) synthesis (directly via tyramine hydroxylation and indirectly through precursor demethylation), recent research has highlighted less-studied CYPs...