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Science, Volume 387, Issue 6740, Page 1301-1305, March 2025.

Science, Volume 387, Issue 6740, Page 1276-1280, March 2025.

Science, Volume 387, Issue 6740, Page 1281-1286, March 2025.

Science, Volume 387, Issue 6740, Page 1260-1260, March 2025.

Science, Volume 387, Issue 6740, Page 1261-1261, March 2025.

Follow President Donald Trump’s impact on U.S. research and science globally

Researchers discover rare example of defensive mimicry in birds

Baby-friendly imaging challenges long-standing assumptions about “infantile amnesia”

The latest in science and policy

The island country has become the world’s leading exporter of long-tailed macaques, pitting politicians, conservationists, and neighbors against each other

A drug candidate with a new mechanism of action shows promise against several drug-resistant infections in mice

High nitrogen in Neanderthal bones doesn’t mean they were uber-carnivores

Genome-wide association studies (GWAS) have identified loci associated with kidney diseases, but the causal variants, genes, and pathways involved remain elusive. Here, we identified a kidney disease gene called pancreatic progenitor cell differentiation and proliferation factor (PPDPF) through integrating GWAS on kidney function and multiomic analysis. PPDPF was predominantly expressed in healthy proximal tubules of human and mouse kidneys via single-cell analysis. Further investigations...

Our previous transcriptomic analysis revealed an up-regulation of the antiapoptotic protein B cell lymphoma-extra large (Bcl-xL) in centenarians relative to octogenarians or younger cohorts. In this study, we used Bcl-xL-overexpressing mice to assess its impact on successful aging. Our findings indicate that Bcl-xL overexpression modifies T cell subsets and improves their metabolism, apoptosis resistance, macroautophagy, and cytokine production during aging. This more resilient immune system...

Defective DNA damage response (DDR) and mitochondrial dysfunction are a major etiology of tissue impairment and aging. Mitochondrial autophagy (mitophagy) is a mitochondrial quality control (MQC) mechanism to selectively eliminate dysfunctional mitochondria. ATR (ataxia-telangiectasia and Rad3-related) is a key DDR regulator playing a pivotal role in DNA replication stress response and genomic stability. Paradoxically, the human Seckel syndrome caused by ATR mutations exhibits premature aging...

CONCLUSION: The ML results indicate that two tree-based methods (RF and GB) are reliable and effective as initial models for classification tasks involving discrete clinical aging and neurodegeneration data. In the XAI phase, SHAP performed better than LIME due to lower computational time (when applied to RF and GB) and incorporation of feature interactions, leading to more reliable results.

This review focuses on sexual dimorphism in cellular senescence and senolytic treatment in relation to brain health and age-related cognitive decline. The stressors of aging, DNA damage, inflammation, and oxidative stress induce cell senescence, a hallmark of aging. Senescent cells change their function and molecular profile and are primed to release pro-inflammatory cytokines. The functional changes include the activation of cell signals to prevent cell death. The release of pro-inflammatory...

INTRODUCTION: Neurophysiological activity, as noninvasively captured by electro- and magnetoencephalography (EEG and MEG), demonstrates complex temporal fluctuations approximated by typical variations around the mean values and rare events with large amplitude. The statistical properties of these extreme and rare events in neurodynamics may reflect the limits or capacity of the brain as a complex system in information processing. However, the exact role of these extreme neurodynamic events in...

Pennsylvania expands study of whether more social interaction and homier spaces improve health and safety—for incarcerated individuals and staff

Magma protruding in the South China Sea reveals unexpected amounts of water