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In Other Journals

2 weeks 1 day ago
Science, Volume 390, Issue 6774, Page 688-689, November 2025.
Corinne Simonti, and Jesse Smith, L. Bryan Ray, Ekeoma Uzogara, Sarah H. Ross, Caroline Ash, Brad Wible, Jelena Stajic, and Jack Huang

The emergence and diversification of dog morphology

2 weeks 1 day ago
Science, Volume 390, Issue 6774, Page 741-744, November 2025.
Allowen Evin, Carly Ameen, Colline Brassard, Sophie Dennis, Ekaterina E. Antipina, Vincent Bonhomme, Myriam Boudadi-Maligne, Kate Britton, Francisco Gil Cano, Ruth F. Carden, Julien Claude, Lídia Colominas, Stefan Curth, Sergey Egorovich Fedorov, Joan…

Clinically ready magnetic microrobots for targeted therapies

2 weeks 1 day ago
Science, Volume 390, Issue 6774, Page 710-715, November 2025.
Fabian C. Landers, Lukas Hertle, Vitaly Pustovalov, Derick Sivakumaran, Cagatay M. Oral, Oliver Brinkmann, Kirstin Meiners, Pascal Theiler, Valentin Gantenbein, Andrea Veciana, Michael Mattmann, Silas Riss, Simone Gervasoni, Christophe Chautems, Hao Ye,…

Single-nucleus multi-omics identifies shared and distinct pathways in Pick's and Alzheimer's disease

2 weeks 2 days ago
The study of transcriptomic and epigenomic variations in neurodegenerative diseases, particularly tauopathies like Pick's disease (PiD) and Alzheimer's disease (AD), offers insights into their underlying regulatory mechanisms. Here, we identified critical regulatory changes driving disease progression, revealing potential therapeutic targets. Our comparative analyses uncovered disease-enriched noncoding regions and genome-wide transcription factor (TF) binding differences, linking them to target...
Zechuan Shi

iPEX enables micrometre-resolution deep spatial proteomics via tissue expansion

2 weeks 2 days ago
The number of spatial omics technologies being developed is increasing¹. However, a missing tool is one that can locate proteins in tissues in an untargeted manner at high spatial resolution and coverage. Here we present in situ imaging proteomics via expansion (iPEX), which integrates isotropic tissue magnification² with matrix-assisted laser desorption/ionization (MALDI) mass spectrometry imaging. iPEX provides scalable spatial resolution down to the micrometre scale and substantially...
Fengxiang Wang