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US academics: look after foreign students
How close is AI to human-level intelligence?
Author Correction: Genetic drivers and cellular selection of female mosaic X chromosome loss
To unlock mutual benefits, don’t restrict US–China genome data transfer
China’s climate investments in Africa must promote mutual benefit
Public trust in science can be diminished by communicating uncertainty
Science must up its game to support climate finance negotiations
House panel concludes that COVID-19 pandemic came from a lab leak
Two-year probe led by Republicans faults agencies for pandemic response, as Democrats on panel challenge final report’s findings on SARS-CoV-2’s origin
‘Brutal’ math test stumps AI but not human experts
Benchmark shows humans can still top machines—but for how much longer?
Could melting ice wake up Antarctica’s volcanoes?
Researchers probe immediate and long-term threats at two of continent’s biggest magmatic tinderboxes
India takes out giant nationwide subscription to 13,000 journals
Deal allows scholars to read paywalled articles for free and will cover open-access fees
Controversial study redraws classical picture of the neuron
Fine-grained imaging of mouse brain cells suggests “pearling” of axons that researchers think may help with signaling
Portable, low-field magnetic resonance imaging for evaluation of Alzheimer's disease
Portable, low-field magnetic resonance imaging (LF-MRI) of the brain may facilitate point-of-care assessment of patients with Alzheimer's disease (AD) in settings where conventional MRI cannot. However, image quality is limited by a lower signal-to-noise ratio. Here, we optimize LF-MRI acquisition and develop a freely available machine learning pipeline to quantify brain morphometry and white matter hyperintensities (WMH). We validate the pipeline and apply it to outpatients presenting with mild...
A cautionary tale for Alzheimer's disease GWAS by proxy
No abstract
Establishment of primary and immortalized fibroblasts reveals resistance to cytotoxic agents and loss of necroptosis-inducing ability in long-lived Damaraland mole-rats
The Damaraland mole-rat (DMR; Fukomys damarensis) is a long-lived (~ 20 years) Bathyergid rodent that diverged 26 million years ago from its close relative, the naked mole-rat (NMR). While the properties of NMR cultured fibroblasts have been extensively studied and have revealed several unusual features of this cancer-resistant, long-lived species, comparative DMR studies are extremely limited. We optimized conditions for successfully culturing primary DMR skin fibroblasts and also established...
A chimeric peptide promotes immune surveillance of senescent cells in injury, fibrosis, tumorigenesis and aging
The accumulation of senescent cells can lead to tissue degeneration, chronic inflammatory disease and age-related tumorigenesis. Interventions such as senolytics are currently limited by off-target toxicity, which could be circumvented by instead enhancing immune-mediated senescent cell clearance; however, immune surveillance of senescent cells is often impeded by immunosuppressive factors in the inflammatory microenvironment. Here, we employ a chimeric peptide as a 'matchmaker' to bind to the...
Association between cardiovascular risk and diastolic blood pressure in older adults with systolic blood pressure less than 130mmHg: a prospective cohort study from 2014 to 2022
CONCLUSION: In older adults with SBP < 130 mmHg, DBP values 80-89 mmHg were not associated with higher risk of CV organ damage, events or mortality.
Relationship between participation in leisure activities and the maintenance of successful aging in older Chinese adults: a 4-year longitudinal study
CONCLUSIONS: These findings suggest that individuals who participated more frequently in more leisure activities had a higher chance of the maintenance of successful aging in older adults. Encouraging older people to frequently participate in a greater variety of leisure activities may be an effective way to maintain successful aging over time.
The bidirectional association between self-perceptions of aging and frailty: the mediating role of subjective cognitive decline
CONCLUSION: This study demonstrates a bidirectional causal relationship between self-perceptions of aging and frailty, with subjective cognitive decline identified as a mediating mechanism. These findings provide important guidance for future efforts aimed at reducing frailty rates among older adults in community settings.
Nutrient-dense foods and diverse diets are important for ensuring adequate nutrition across the life course
The world faces a global challenge of how to meet the nutritional needs of a diverse global population through diets. This paper defines the relative nutritional needs across each stage of the life cycle to support human health and identifies who is nutritionally vulnerable. Findings in this paper suggest that there are biological nutritional vulnerabilities stemming from high micronutrient needs per calorie in certain phases of the life cycle, particularly for infants and young children, women...