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Molecular insights into diverse heat hormesis regimens in Caenorhabditis elegans
Heat hormesis describes a biphasic, dose-dependent response in which low levels of heat stress induce beneficial effects, such as enhanced lifespan and stress resilience. This phenomenon is commonly studied in Caenorhabditis elegans using regimens that involve mild heat stress priming, followed by a recovery period and subsequent stress challenge or lifespan measurement. The concept is conserved across species and has gained renewed interest due to its potential relevance to therapeutic...
Oxidative stress in frailty among older adults: are malondialdehyde and superoxide dismutase the key biomarkers?
Frailty is a significant health issue among older adults. Oxidative stress (OS), indicated by elevated malondialdehyde (MDA) levels and reduced superoxide dismutase (SOD) activity, is implicated in age-related diseases. This study aims to explore the relationship between OS biomarkers, MDA and SOD, and frailty among older adults. This study investigated the association between MDA, SOD, and frailty in 3181 older adults from the Chinese Longitudinal Healthy Longevity Survey (CLHLS). Frailty was...
p62/SQSTM1 Condensation Modulates Mitochondrial Clustering to Participate in Mitochondrial Quality Control
Mitochondrial quality control is tightly associated with aging-related neurodegenerative diseases such as Parkinson's disease, Alzheimer's disease, amyotrophic lateral sclerosis (ALS), and frontotemporal dementia (FTD). Previous studies reported that ALS/FTD-associated protein p62 drives "mitochondrial clustering" (perinuclear clustering of fragmented and swollen mitochondria) during PINK1/Parkin-mediated mitophagy, but the underlying molecular mechanism, especially the precise role of p62 in...
Physical activity, health symptoms, and falls in older adults with different cognition levels: evidence from the Health and Retirement Study
CONCLUSIONS: Moderate and high-intensity PA were associated with lower odds of falls, with important effect modification by cognitive status and health symptoms. These findings suggest that fall prevention strategies should account for cognitive function and symptom burden when promoting physical activity in older adults.
Challenges to continuity of care in volunteer-integrated services for older adults: a mixed-methods study in urban China
CONCLUSIONS: Bridging the willingness-utilization gap requires systemic reform across policy, organizational, service, and individual levels. Priorities include expanding LTCI eligibility, formalizing volunteer roles within interdisciplinary teams, establishing navigation mechanisms for unmet "grey-zone" needs, and enhancing digital literacy through hybrid information systems. By extending Haggerty's continuity framework beyond clinical care, this study illustrates how volunteers can be...
Evaluating a Mobile Integrated Health Transitional Care Program to Reduce Readmissions: Findings From a Quasi-Experimental Design
CONCLUSIONS: An in-home mobile integrated health (MIH) transitional care program for frail older adults after hospital discharge was associated with lower 30-day readmission rates. These findings highlight MIH as a promising model to support aging in place and suggest its potential value for adoption within age-friendly health systems.
p62/SQSTM1 Condensation Modulates Mitochondrial Clustering to Participate in Mitochondrial Quality Control
Mitochondrial quality control is tightly associated with aging-related neurodegenerative diseases such as Parkinson's disease, Alzheimer's disease, amyotrophic lateral sclerosis (ALS), and frontotemporal dementia (FTD). Previous studies reported that ALS/FTD-associated protein p62 drives "mitochondrial clustering" (perinuclear clustering of fragmented and swollen mitochondria) during PINK1/Parkin-mediated mitophagy, but the underlying molecular mechanism, especially the precise role of p62 in...
Secretome Profiling of Young Multipotent Stem Cells Reveals Angiogenic and Immunomodulatory Mechanisms Supporting Aged Neuromuscular Health
Aging is the primary risk factor for many neuromuscular (NM) diseases that impair motor and cognitive function. Transplantation of young muscle-derived stem/progenitor cells (MDSPCs) has shown remarkable therapeutic potential across a range of age-related diseases, primarily through paracrine mechanisms. In this study, secretome profiling of young MDSPCs revealed a unique enrichment of pro-angiogenic and immunomodulatory proteins compared to their aged counterparts. Our systemic transplantation...
Can science build a better working dog?
New approaches could put talented canines into the hands of more people with disabilities
Politics and war complicate global effort to study changes to Earth’s poles
As preparations for the fifth International Polar Year kick off, organizers grapple with U.S. climate skepticism and Russia’s invasion of Ukraine
A Yangtze without fishers — but not without fish
Daily briefing: Hunter-gatherers in Europe’s ‘water world’ resisted the switch to farming for millennia
Grant proposals drafted with AI help more likely to win NIH funding
US repeals key ‘endangerment finding’ that climate change is a public threat
How some COVID vaccines triggered rare blood-clot disorder
Stewarding AI in agriculture research
Science, Volume 391, Issue 6786, February 2026.
Erratum for the Research Article “WAPL functions as a rheostat of Protocadherin isoform diversity that controls neural wiring”
Science, Volume 391, Issue 6786, February 2026.
Erratum for the Research Article “Of the first five US states with food waste bans, Massachusetts alone has reduced landfill waste”
Science, Volume 391, Issue 6786, February 2026.
Mechanisms linking cytoplasmic decay of translation-defective mRNA to transcriptional adaptation
Science, Volume 391, Issue 6786, February 2026.
Mitochondrial control of fuel switching via carnitine biosynthesis
Science, Volume 391, Issue 6786, February 2026.