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Uncovering the secrets of syphilis
Science, Volume 391, Issue 6783, Page 352-353, January 2026.
Tethered platelets in severe infection
Science, Volume 391, Issue 6783, Page 349-350, January 2026.
Meeting the need for myelin
Science, Volume 391, Issue 6783, Page 351-352, January 2026.
Tracking space debris from sonic booms
Science, Volume 391, Issue 6783, Page 348-349, January 2026.
In Other Journals
Science, Volume 391, Issue 6783, Page 364-365, January 2026.
The price of prestige
Science, Volume 391, Issue 6783, Page 418-418, January 2026.
Couple-close: Unified approach to semisaturated cyclic scaffolds
Science, Volume 391, Issue 6783, Page 399-406, January 2026.
Observation of one-dimensional, charged domain walls in ferroelectric ZrO2
Science, Volume 391, Issue 6783, Page 407-411, January 2026.
Reentry and disintegration dynamics of space debris tracked using seismic data
Science, Volume 391, Issue 6783, Page 412-416, January 2026.
Observation of the Einstein–de Haas effect in a Bose–Einstein condensate
Science, Volume 391, Issue 6783, Page 384-388, January 2026.
143–million-year seawater osmium isotopic record: Trends, rhythms, and dynamics of volcanism and tectonics
Science, Volume 391, Issue 6783, Page 389-393, January 2026.
Multiparameter estimation with an array of entangled atomic sensors
Science, Volume 391, Issue 6783, Page 374-378, January 2026.
Mitigating clean energy’s dirty costs
Science, Volume 391, Issue 6783, Page 358-358, January 2026.
Narratives of conflict in a warming Arctic
Science, Volume 391, Issue 6783, Page 359-359, January 2026.
Falling space junk can be tracked from its sonic booms
Seismic stations can accurately map re-entering debris with high accuracy
Magnetically sensitive proteins could lead to new imaging tools and remote-controlled drugs
New study shows how engineered proteins can be tracked with an MRI-like approach
These ancient handprints may represent some of the world’s first rock art
Hand stencils from a Southeast Asian cave predate Neanderthal cave art from Europe
Evaluating Senescence-Targeted Approaches in Alzheimer's Disease: What We Know and What Lies Ahead
Alzheimer's disease (AD) is a progressive and irreversible neurodegenerative disease, which represents the most prevalent dementia worldwide. Although amyloid-β (Aβ) and tau pathology have been the classic focus of treatment, accumulating evidence indicates that ageing-associated cellular senescence plays a central role in AD pathogenesis. Senescent neurons, astrocytes, microglia and endothelial cells accumulate in the ageing and Alzheimer's brain and adopt a senescence-associated secretory...
Cell type-specific gene regulatory atlas prioritizes drug targets and repurposable medicines in Alzheimer's disease
Alzheimer's disease (AD) is a complex and poorly understood neurodegenerative disorder that lacks sufficiently effective treatments. Computational and integrative analyses that leverage multiomics data provide a promising strategy to uncover disease mechanisms and identify therapeutic opportunities. Here, we develop a cell type-specific regulatory atlas of the human middle temporal gyrus via leveraging single-nucleus RNA-seq (1,197,032 nuclei) and ATAC-seq (740,875 nuclei) datasets from 84...
DNA nanodevices detect an acidic nanolayer on the lysosomal surface
Lysosomes maintain a highly acidic lumen to regulate H^(+)-dependent hydrolase-mediated degradation, but how protons are 'leaked' out to regulate organellar functions through cytosolic effectors remains unknown. Here we developed DNA nanodevices on the cytosolic leaflet of lysosomal membranes to monitor juxta-organellar pH in cells. Unexpectedly, we revealed a radiating acidic layer (up to 21 nm in thickness) on the outer surface of all lysosomes, typically 0.2-0.7 pH units more acidic than the...