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Cell-type-resolved genetic variation shapes inflammatory bowel disease risk
Teosinte alleles enhance nitrogen assimilation and seed protein in maize
Cold-induced peptide signalling secures pollen resilience and crop yield
Mining triggers extensive additional deforestation in sub-Saharan Africa
Acquired genetic and cell-state changes in IDH-mutant glioma progression
Relativistic electron acceleration at the bow shock of Jupiter and beyond
Earth’s east–west albedo symmetry
A natural depsipeptide antibiotic binds the E-site of the bacterial ribosome
The size of tropical vegetation gross primary production
Reply to: The size of tropical vegetation gross primary production
Your phone can use tiny skin-colour changes to measure your heart rate
AI in science recruitment: friend or foe? Join our free webinar
Editorial Expression of Concern: Functional proteomic identification of DNA replication proteins by induced proteolysis <i>in vivo</i>
Can an army of babies and dogs rescue psychology from its reproducibility crisis?
Microsoft upgrades controversial quantum chip — researchers are still sceptical
Book of Cron Job
Why a synthetic human genome is still worth building
Scientists discovered something surprising about french fries and diabetes
French fries may be the real potato problem. A large study tracking more than 205,000 people for nearly 40 years found that eating three servings of fries per week was linked to a 20% higher risk of developing type 2 diabetes, while baked, boiled, or mashed potatoes showed no significant increase in risk. The research also found that swapping potatoes for whole grains lowered diabetes risk, while replacing them with white rice had the opposite effect.
Brain scans reveal two distinct types of autism
Scientists have uncovered evidence that autism may include at least two biologically distinct subtypes, each marked by a different pattern of brain communication. By combining brain scans from nearly 1,000 people with autism with insights from 20 genetically engineered mouse models, researchers identified a “hyperconnectivity” subtype, where brain regions communicate more than usual, and a “hypoconnectivity” subtype, where communication is reduced.
A single protein may be holding back CAR T cancer therapy
A newly identified protein may be one of the biggest obstacles holding CAR T-cell therapy back. Researchers found that NFIL3 causes these engineered immune cells to become exhausted and lose their cancer-fighting power over time. When NFIL3 was disabled, the cells remained stronger for longer and controlled tumors more effectively in animal models.