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Growing pains
Science, Volume 391, Issue 6782, Page 322-322, January 2026.
Transforming mental health research and care through artificial intelligence
Science, Volume 391, Issue 6782, Page 249-258, January 2026.
Complex mesoscale landscapes beneath Antarctica mapped from space
Science, Volume 391, Issue 6782, Page 314-319, January 2026.
Paleogeography modulates marine extinction risk throughout the Phanerozoic
Science, Volume 391, Issue 6782, Page 285-289, January 2026.
The photohydrolysis of furans
Science, Volume 391, Issue 6782, Page 267-274, January 2026.
Low-frequency earthquakes track the motion of a captured slab fragment
Science, Volume 391, Issue 6782, Page 294-299, January 2026.
Ablation of Prdm16 and beige fat identity causes vascular remodeling and elevated blood pressure
Science, Volume 391, Issue 6782, Page 306-313, January 2026.
Chronic low-dose exposure to chlorpyrifos reduces life span in a wild fish by accelerating aging
Science, Volume 391, Issue 6782, Page 275-279, January 2026.
A sudden change and recovery in the magnetic environment around a repeating fast radio burst
Science, Volume 391, Issue 6782, Page 280-284, January 2026.
Careful science is valuable, regardless of results
Science, Volume 391, Issue 6782, Page 246-246, January 2026.
The branching legacies of America’s past
Science, Volume 391, Issue 6782, Page 245-245, January 2026.
Illegal miners have forced Peru’s oldest environmental research station to suspend work
Staff at the Panguana biological research station have received death threats
What’s below Antarctica’s ice? New map provides clearest view yet
Technique could improve models of how ice flows, bolstering predictions of sea level rise
Scientists turn cells’ most mysterious structures into spies on genetic activity
Enigmatic ‘vaults’ can be engineered to eavesdrop on RNA, aiding cancer studies and more
On a Galápagos island, a ‘restoration project on steroids’
A multimillion-dollar plan aims to undo centuries of destruction on islands made famous by Darwin
In fish, low doses of common pesticide speed aging and death
Polluted lakes and lab experiments highlight harms of chronic exposure to chlorpyrifos
Chinese telescope in Antarctica probes uncharted heavenly radiation
Terahertz instrument at Dome A, world’s driest spot, traces the faint glow of gases beyond other telescopes’ reach
Stability of non-canonical nucleic acid structure as a potential modulator of cell fate
Cellular morphological changes occur during cell life and diseases, such as senescence and cancer. Although the cellular conditions should be varied with the morphology changes, there have been no attempts to understand the cellular morphological changes by focusing on the intracellular molecular environment and elucidating the behaviour of nucleic acids. Nucleic acids can form hierarchical secondary and higher-order structures due to intermolecular interactions and other factors. Additionally,...
Visualization and quantification of rDNA instabilities in mammalian cells and mouse models
Ribosomal DNA (rDNA) encodes the 18S, 5.8S, and 28S rRNA, accounting for ∼70% of cellular transcription. Despite its essential role and links to cancer and aging, quantifying rDNA instability in mammals remains challenging due to its repetitive organization and inherent heterogeneity. Here, we developed a murine rDNA FISH probe and genomic tools tailored for laboratory mouse strains. The results confirmed rDNA cluster locations, revealed substantial inter- and intra-strain as well as...
NSMF modulates replication stress to facilitate colorectal cancer progression
Cancer cells precisely modulate replication stress to sustain genomic instability without triggering lethal DNA damage, yet regulators enabling this delicate balance remain largely unknown. Here, we identify N-methyl-D-aspartate receptor synaptonuclear signaling and neuronal migration factor (NSMF) as a novel and critical regulator of replication stress in colorectal cancer (CRC). NSMF expression is significantly elevated in CRC tissues and correlates closely with elevated replication stress. In...