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We reconceptualize p21 as the master regulator of a "resilience network" that empowers cancer cells to defy therapy. Beyond cell cycle arrest, p21 orchestrates a multi-faceted defense, suppressing ferroptosis and cuproptosis by governing redox and metal ion homeostasis. This perspective demands a therapeutic paradigm shift: targeting the p21 network is essential to dismantle this evolved survival machinery and force durable tumor regression in resistant cancers.

Large-scale randomized trials have found that multivitamin-multimineral (MVM) supplements and cocoa flavanols may benefit several age-related chronic conditions among older adults, but it remains unclear whether these two supplements directly slow the biological aging process. This prespecified ancillary study evaluated the 2-year effect of a daily MVM (Centrum Silver) and cocoa extract (500 mg cocoa flavanols per day, including 80 mg (-)-epicatechin) on five DNA methylation measures of...

Aging is associated with reduced cerebrovascular reactivity and impaired neurovascular coupling, limiting the brain's ability to maintain adequate oxygen delivery during physiological stressors such as hypoxia. These vascular changes may heighten middle-aged adults' vulnerability to hypoxia-induced neural and cognitive impairments, yet dose-response data integrating cerebral oxygenation and cognition remain scarce. In a single-blind, randomized crossover trial, 16 participants completed four...

Aging is a major contributor to β-cell dysfunction in type 2 diabetes, with cellular senescence increasingly recognized as an important underlying mechanism. Here, we established a doxorubicin (DOX)-induced senescence model using MIN6 mouse insulinoma β-cell line to elucidate the mechanisms by which senescence remodels organelle homeostasis and insulin secretion. Senescence was validated by senescence-associated β-galactosidase positivity, p16^(INK4a)/p21/p53 upregulation, and cell cycle arrest....

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Insects can stay alive for up to a week in flooded nests, thanks to several tricks