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Molecular basis of oocyte cytoplasmic lattice assembly
Planar Li deposition and dissolution enable practical anode-free pouch cells
Longitudinal changes in epigenetic clocks predict long-term mortality
Dopamine takes a hit: how neuroscience is rethinking the ‘feel-good’ chemical
How wealthy tech entrepreneurs seek to shape politics, culture and the future — and why we must resist
How I turned online misogyny about my PhD into momentum for my career
AI is programmed to hijack human empathy — we must resist that
AlphaFold database hits ‘next level’: the AI system now includes protein pairing
Marine conservation cities: a model for ocean governance
How the Pokémon franchise has helped to shape neuroscience
Autism in older adults: the health system must recognize its effects
Rethinking AI’s role in survey research: from threat to collaboration
White House lifts hold on NIH research spending
Director Jay Bhattacharya tells House lawmakers that grantmaking, hiring are on track
Colliding currents can target the deep brain without surgery
Human studies show promise of stimulation approach for epilepsy and other diseases
This hot pink cricket is no mutant
Arota festae’s unusual hue may help it blend in with immature plants
A Brazilian scientist’s experimental paralysis therapy is fueling hope—and hype
Spinal cord injury patients are scrambling for access to the injection, but researchers say preliminary evidence is weak
The alpha-synuclein proteostasis network and its translational applications in Parkinson's disease
Parkinson's disease (PD) is a debilitating neurodegenerative condition that results in a loss of mobility and muscle control. A neuropathological hallmark of PD is the presence of aberrant inclusions, known as Lewy pathology, of which α-synuclein (α-Syn) is a major component. The accumulation of α-Syn may be due to an imbalance in the proteostasis system regulating α-Syn. To investigate this hypothesis, we delineated the proteostasis network (PN) of α-Syn in the human substantia nigra at the...
Correction for Chen et al., RNA-binding activity of PHGDH drives amyloid-beta production in a human brain organoid model of sporadic Alzheimer's disease
No abstract
Editorial: Mental, sensory, physical and life style parameters related to cognitive decline in aging
No abstract
The role of glutathione in cognition, cognitive effort, and cognitive endurance in young and older adults
Glutathione (GSH) is an abundant antioxidant that protects against endogenous and exogenous toxic agents. The evidence over the relationship between GSH and cognitive integrity during aging is still scarce. In this study we investigated the relationship between GSH and cognitive integrity, cognitive effort and sustained cognitive effort. Second, we explored whether GSH modulation is related to other physiological properties such as blood oxygenation (BOLD response) and to brain excitability...