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RYR:ATP6V0A1 complexes couple ER-lysosome contact sites to dynamic autophagy control

2 weeks 1 day ago
Ryanodine receptors (RYRs) are ER-resident Ca^(2+)-release channels enriched in excitable cells, including neurons. RYR hyperactivity is implicated in early pathogenesis of disorders such as Alzheimer's disease (AD), which is associated with impaired autophagy. We recently uncovered a mechanism linking RYR activity to lysosome availability for autophagy. RYRs localize to ER-lysosome contact sites via direct binding to ATP6V0A1, a V-ATPase subunit that also suppresses RYR-mediated Ca^(2+)...
Jens Loncke

Lipid dysregulation as a convergent pathway linking environmental exposures to stroke

2 weeks 1 day ago
Stroke remains the second leading cause of death globally, yet traditional risk factors explain only 50-60 percent of cases. Emerging evidence indicates that lipid dysregulation is a central mechanism linking environmental exposures to cerebrovascular vulnerability. Aging, chronic inflammation, infections, diet, inactivity, stress, sleep disorders, and toxins are associated with disruption of lipid homeostasis through oxidative stress-induced lipid peroxidation, cytokine-mediated metabolic...
Maryline Santerre