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Programming touch-me-not knot topologies for rapid and diverse leaping and flying motions
Science, Volume 392, Issue 6796, Page 401-405, April 2026.
Chiral S(VI) platform unifies selective C–H amination of complex molecules and alkane feedstocks
Science, Volume 392, Issue 6796, Page 421-428, April 2026.
[Os(η5-B5H10)2]: A carbon-free analog of ferrocene
Science, Volume 392, Issue 6796, Page 411-414, April 2026.
Sex decreases the pleiotropic costs of local adaptation by purging hitchhiking load
Science, Volume 392, Issue 6796, Page 415-420, April 2026.
Intercalated carbon nanotube fibers with high specific electrical conductivity
Science, Volume 392, Issue 6796, Page 395-400, April 2026.
Earliest octopuses were giant top predators in Cretaceous oceans
Science, Volume 392, Issue 6796, Page 406-410, April 2026.
A cell-nonautonomous heme acquisition pathway enables erythroid hemoglobinization under stress
Science, Volume 392, Issue 6796, Page 388-394, April 2026.
Amazon forest loss: An all-sky biophysical top-of-atmosphere cooling feedback
Science, Volume 392, Issue 6796, Page 429-432, April 2026.
Writing the rainbow
Science, Volume 392, Issue 6796, Page 364-364, April 2026.
Dark discoveries
Science, Volume 392, Issue 6796, Page 363-363, April 2026.
U.S. moves to reclassify some types of marijuana as lower risk
Long-awaited policy shift could ease barriers for scientists who study the drug
Thousands of shady ads sell paper authorship for cash, large-scale investigation finds
Results are “only the tip of the iceberg” of shadowy paper-mill marketplace
Sperm carry unexpected genetic messages
Maturing mouse sperm get loaded with full-length messenger RNAs that are transferred to fertilized egg, suggesting a new route for paternal influence
Gene therapy for deafness approved
First treatment for an inherited hearing disorder will be free in the United States
As U.S. pushes to expand uranium mines, opponents warn of ‘ticking time bomb’
Method that leaches radioactive metal from aquifers can leave groundwater contaminated, researchers say
Octopus ‘krakens’ as large as semi-trucks stalked ancient seas
Giant cephalopods may have rivaled marine reptiles as apex predators during the age of the dinosaurs
Ancient South Americans arrived in three waves—and had some surprising ancestry
Genetically diverse groups arrived in three waves, some potentially carrying genes acquired from long-ago Australasian ancestors
Somatic cancer variants enriched in Alzheimer's disease microglia-like cells drive inflammatory and proliferative states
Alzheimer's disease (AD) is a neurodegenerative condition characterized by microglia-mediated neuroinflammation. Deep (>1,000×) panel sequencing of 311 brain samples revealed enrichment of somatic single-nucleotide variants (sSNVs) in cancer driver genes in AD brains, especially in genes associated with clonal hematopoiesis (CH). These sSNVs were associated with clonal expansion and carried by both microglia-like brain macrophages (MLBMs) in multiple brain regions as well as paired blood,...
A skeletal muscle atlas shows neuromuscular junction adaptations to growth and atrophy
The molecular basis underlying muscle atrophy, as it occurs during disuse or aging, and activity-induced hypertrophy remain poorly understood. A major challenge has been defining the diverse cellular and niche environments within skeletal muscle, which is mostly composed of multinucleated myofibers. Here, we present a single-nucleus and single-cell transcriptomic atlas, coupled with spatial profiling, of mouse limb skeletal muscle under resting conditions and during experimentally induced...
A generative AI framework unifies human multi-omics to model aging, metabolic health, and intervention response
Understanding aging and complex diseases requires diverse data, ranging from molecular profiles to imaging and routine clinical tests. However, most multi-omic datasets measure only a subset of modalities and are confounded by batch effects. Here, we present AURORA (AI unification and reconstruction of omics reassembly atlas), a generative deep-learning platform that integrates seven modalities (including transcriptomics, metabolomics, microbiome, 3D and thermal facial imaging, and clinical...