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Ligand-specific activation trajectories dictate GPCR signalling in cells
3D-printed low-voltage-driven ciliary hydrogel microactuators
A foundation model for continuous glucose monitoring data
Coherent nonlinear X-ray four-photon interaction with core-shell electrons
Training large language models on narrow tasks can lead to broad misalignment
Direct observation of the Migdal effect induced by neutron bombardment
Exciplex-enabled high-efficiency, fully stretchable OLEDs
Microbiota-induced T cell plasticity enables immune-mediated tumour control
Dominant contribution of Asgard archaea to eukaryogenesis
Mosaic lateral heterostructures in two-dimensional perovskite
Retraction Note: Antibodies against endogenous retroviruses promote lung cancer immunotherapy
AI can turbocharge scientists’ careers — but limit their scope
Do you have a side hustle alongside your PhD studies? Take <i>Nature</i>’s poll
What the future holds for AI – from the people shaping it
Ancient pottery reveals early evidence of mathematical thinking
Slow grower: <em>Tyrannosaurus rex</em> didn’t reach full size until age 40
Famed dino likely spent much of its life competing for food against smaller predators
How to cool down African homes—and keep mosquitoes out
Painting roofs white and adding screens to doors and windows is a low-cost way to increase comfort and curb malaria risk
Angiopoietin-2 aggravates Alzheimer's disease by promoting blood-brain barrier dysfunction and neuroinflammation
Disruption of the blood-brain barrier (BBB) increases vascular permeability and promotes neuroinflammation, contributing to Alzheimer's disease (AD) progression. However, the molecular drivers of BBB dysfunction and neuroinflammation in AD remain poorly defined. Here, we identify angiopoietin-2 (ANGPT2) as a central mediator of BBB breakdown and AD progression. Transcriptomic analyses of human AD brains revealed elevated ANGPT2 expression in endothelial cells correlating with disease severity....
Alpha band activity mediates age-related effects on three distinct aspects of working memory dynamics
Working memory (WM) processes decline with increasing age. According to recent concepts, it is necessary to differentiate between dynamically changing 'WM states' which are regulated via gating mechanisms. We investigated which neural oscillatory processes underlying WM gating and updating are affected by age with a focus on alpha and theta band activity. With an EEG beamforming approach, we examined the data of N = 132 healthy individuals aged 18-76 years who performed the reference-back...
Muscle ultrasonography texture in young, middle-aged, and older people and its association with functional performance: A machine learning-based study
CONCLUSION: Texture analysis combined with machine learning could provide non-invasive biomarkers to classify muscles of young and old individuals, and assist in function prediction.