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Deletion of Mfn2 in endothelial cells triggers a mitohormetic response that improves systemic metabolism and healthspan in mice

2 weeks 4 days ago
Endothelial cells (ECs) are key metabolic gatekeepers, yet their role in metabolic health remains unclear. Given their central involvement in energy metabolism, mitochondria are ideally positioned to enable ECs to adapt to ever-changing metabolic requirements. Here, we explore the hypothesis that mitochondrial dynamics proteins in ECs influence whole-body metabolic status. Genetic deficiency of Mfn2 in ECs (Mfn2^(iΔEC)), but not of Mfn1^(iΔEC), induces a mitohormetic response in the adipose...
Iñigo Chivite

Which aspects of the everyday behavior of older dogs correlate with performance on a visuo-spatial memory test and the canine cognitive dysfunction rating scale (CCDR)?

2 weeks 4 days ago
The behavioral aspects of aging in the domestic dog have primarily been investigated through owner-reported scales that measure specific behavioral signs of aging, and laboratory-based memory and cognitive tests. We need to know more about how aging affects everyday behavior and functionality in owned dogs. This study tested a methodology for identifying patterns in everyday physical and behavioral function associated with behavioral tests and scales. Fifty-seven family dogs aged 8+ years were...
E García

Carbonated ultramafic igneous rocks in Jezero crater, Mars

2 weeks 4 days ago
Science, Volume 391, Issue 6787, February 2026.
Kenneth H. Williford, Kenneth A. Farley, Briony H. N. Horgan, Brad Garczynski, Allan H. Treiman, Sanjeev Gupta, Alexander J. Jones, Sandra Siljeström, Elise Clavé, Lisa Mayhew, Jeffrey T. Osterhout, Eleni Ravanis, Kathryn M. Stack, Sarah Fagents, Candice…