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Multi-modality profiling identifies <i>Neisseria flavescens</i> as a central geroprotective oral commensal in humans
Publisher Correction: Physical activity delays ovarian aging in part through adiponectin-related signaling pathways
GLP-1 drugs fail to help some people lose weight — scientists are on a quest for answers
AlphaFold ‘goes viral’: database adds protein complexes of common viruses
AI agent hacks government website for first time: why this breach matters
AI system helps lab devices ‘talk’ with each other — streamlining research
Youthful fans of YouTube sports videos stick to the sofa
Bumblebees don’t mind a little plastic in their honeypots
Verification makes discovery matter
Science, Ahead of Print.
In-cell structures visualize human pre-ribosome assembly in the nucleolus
Science, Ahead of Print.
Stereodivergent telomerization of linear functionalized dienes with amines
Science, Ahead of Print.
Antiferroelectric hafnia down to the 2D limit
Science, Ahead of Print.
More REM sleep linked to lower risk of 83 diseases
A large study tracking more than 95,000 people suggests that how you sleep may be linked to your risk of developing dozens of diseases. People who spent more time in REM sleep had lower risks of 83 conditions, including dementia, heart failure, and Parkinson’s disease, while more deep sleep was associated with lower risks of conditions such as type 2 diabetes and major depression.
GLP-1 weight loss and diabetes drugs linked to nutritional deficiencies in nearly 1 in 6 children
Children taking GLP-1 medications (such as Victoza, Saxenda, Trulicity, and Ozempic) for weight loss, prediabetes, or type 2 diabetes may face an overlooked risk: nutritional deficiencies. A new study found that nearly 1 in 6 young patients developed a diagnosed deficiency within a year of starting treatment, with vitamin D deficiency affecting about 12%.
Little-known arm of immune system could be key to better vaccines, cancer therapies
The CD1 system responds to lipids, not proteins, driving reactions to bee stings, bacteria, and possibly poison ivy
NIH details $170 million biomedical research reproducibility effort
Agency director announces literature search tool, other plans to improve reliability of science findings
Rare pregnancy infections may triple the risk of autism
A major Swedish study of 3.7 million people has found that rare TORCH infections passed from a pregnant woman to the fetus are linked to much higher risks of autism and intellectual disability later in life. Children with a congenital TORCH infection were about three times more likely to be diagnosed with autism, more than seven times more likely to have an intellectual disability, and up to 30 times more likely to have severe to profound intellectual disability.
Breakthrough drug reverses skin aging and dramatically speeds healing
A topical drug that removes aging, damaged cells helped older mice heal skin wounds significantly faster. The treatment appeared to reactivate repair pathways involved in inflammation, collagen production, and new blood vessel growth.
Can an AI feel pain? It can at least act like it does
Study reignites debate over what, if anything, machines can feel
Personalized single-cell transcriptomics reveals molecular diversity in Alzheimer's disease
Alzheimer's disease (AD) is highly heterogeneous and driven by diverse molecular and cellular mechanisms. Functional genomics investigates these mechanisms from genetic variants to gene expression and regulation. We performed personalized functional genomics analysis on population-scale single-nucleus RNA-seq data, with cross-cohort validation across multiple cohorts comprising over 1900 individual brains, capturing donor-level cell type interactions and gene regulatory networks. Using a...