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Association of healthy lifestyle patterns with changes in physical frailty and subjective cognitive function among community-dwelling older adults: a 3-year longitudinal study

2 weeks 3 days ago
CONCLUSIONS: Different lifestyles were associated with different health risks in older adults. These lifestyle patterns, such as low physical activity and social participation, were associated with increased physical frailty and subjective cognitive decline. These findings suggest that latent class analysis may be useful for identifying lifestyle patterns that could inform the development of targeted interventions to promote healthy aging.
Mengjiao Yang

Biological Aging Acceleration in Major Depressive Disorder: A Multi-Omics Analysis

2 weeks 3 days ago
Major depressive disorder (MDD) is linked to a higher risk of premature aging, but the mechanisms underlying this association remain unclear. Using data from two population cohorts (UK Biobank and Finnish Twin Cohort), we evaluate the relationship between systemic and organ-specific proteomic and epigenetic aging acceleration and MDD. A lifetime history of MDD was associated with accelerated proteomic aging at both systemic and organ-specific levels-including the brain-in both cohorts, with...
Breno Satler Diniz

In Science Journals

2 weeks 4 days ago
Science, Volume 390, Issue 6777, Page 1012-1014, December 2025.
Michael Funk, and Jelena Stajic, Di Jiang, Phil Szuromi, Michael A. Funk, Madeleine Seale, Annalisa VanHook, Marc S. Lavine, Christiane P. Koch, Caroline Ash, Ekeoma Uzogara, Christiana N. Fogg, and Molly Ogle