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The growing evidence that existing cardio-renal-metabolic therapies, such as GLP-1 receptor agonists and SGLT2 inhibitors, confer all-cause mortality benefits has positioned them as the first wave of potential gerotherapeutics. However, repurposing these drugs for a lifespan extension indication remains constrained by trial duration, misaligned incentives, and the lack of a viable regulatory path. We highlight two parallel strategies to address these barriers: (1) identifying and validating...

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The steroid hormone dafachronic acid may carry the effects of reduced mTOR activity between tissues to coordinate metabolism and longevity across the body.

Advanced brain age relative to chronological age may predict cognitive decline in healthy aging, but prospective evidence remains limited. We tested whether the brain age gap (BAG) predicts cognition and 5-year cognitive decline in the AGES-Reykjavik Study. Participants with structural MRI and neuropsychological data were included cross-sectionally (n = 4,606); mean age 76.4y; 58% female) and longitudinally (n = 2,561; mean follow-up 5.2y). BAG was estimated from T1-weighted MRI. Mixed-effects...

Cellular senescence is characterized by coordinated disruptions in mitochondrial function and epigenetic regulation, with perturbation of the mitochondria-chromatin axis emerging as a central hallmark of this process. Resveratrol (RSV) has been extensively investigated as a modulator of this axis; however, its clinical utility is constrained by dose-dependent cytotoxicity. Here, we evaluated the safety profile and anti-aging potential of resveratrol glucoside (R-glc), a glucosylated derivative...

Aging is modulated by conserved nutrient-sensing pathways that integrate metabolic cues to regulate growth, stress resilience, and lifespan. Caloric restriction (CR) extends longevity across species, motivating the search for compounds that engage related physiology. Lysergic acid diethylamide (LSD), a classic serotonergic psychedelic with emerging therapeutic applications, remains unexplored in the context of aging. Here we show that chronic exposure to nanomolar LSD extends lifespan in...

Cytotoxic chemotherapy typically results in the elimination of a fraction of the tumor with surviving cells entering a state of persistence or premature replicative senescence that can lead to recurrence. Here, we show that therapy-induced senescence is associated with robust up-regulation of Fas and/or TRAIL-R2/DR5 death receptors in vitro and in vivo. The latter receptors restricted entry to senescence and exerted selective pressure on senescent cells through promoting assembly of proapoptotic...

A tiny region deep within the brain has surprised scientists by revealing a remarkably sophisticated communication system. Previously thought to broadcast the same chemical signal throughout the brain, this region actually sends targeted messages that help control learning, attention, and behavior, according to new research in mice.

Ancient DNA connects teeth in a cave offering to people buried in faraway elite tombs