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Although plasma pTau181 has been shown to accurately discriminate patients with Alzheimer's disease from healthy older adults, there are few studies of plasma biomarkers among middle-aged populations. Given the potential utility of plasma AD biomarkers such as pTau181 in screening for disease risk, examining pTau181 in a middle-aged cohort without AD is important for future implementation. The objectives of this study were to characterise plasma pTau181 in a middle-aged birth cohort aged 45...

Chronic sympathetic nerve activity (SNA) to end organs plays a crucial role in the pathophysiology of obesity-induced hypertension. Oxidative stress and neuroinflammation in the rostral ventrolateral medulla (RVLM), a key brainstem region regulating sympathetic outflow, have been implicated in the sympathetic overactivity in obesity. However, the upstream mechanisms driving RVLM neuroinflammation remain unknown. We hypothesized that obesity induces cellular senescence, a stress response...

CONCLUSION: Through integrated transcriptomic analysis together with in vitro experimental validation, this study indicates that TMEM140 may be a candidate bridge molecule connecting PD and AD comorbidity. TMEM140 may participate in shaping the peripheral-central immunosenescence network and contribute to the cross-system transmission of inflammatory signaling.

Scientists have uncovered a surprising way to influence the bacteria living in our mouths — not by killing them, but by interrupting how they “talk” to each other. Researchers found that dental plaque bacteria use chemical signals to coordinate growth, and by blocking those signals, they were able to encourage healthier bacteria while reducing disease-linked microbes tied to gum disease. Even more intriguing, the bacterial conversations changed depending on oxygen levels above and below the gums, revealing an entirely new layer of complexity inside the mouth.

Beneath the beauty of coral reefs lies a hidden universe of microbes unlike anything scientists expected. Each coral species supports its own specialized microbial partners, many of which have never been studied before. These microbes produce a stunning variety of chemical compounds with potential uses in medicine and biotech. The discovery highlights just how much is at stake as coral reefs face growing threats.

State Department would send PEPFAR money directly to countries, which could then pay fees to health agency for help

Katherine Yelick will become director of the Department of Energy’s Lawrence Berkeley National Laboratory on 1 July

Many cancer patients turn to biotin supplements hoping to restore hair lost during treatment, but experts warn the popular vitamin may do more harm than good. While biotin is often marketed for stronger hair and nails, there’s little evidence it actually helps cancer-related hair loss—and it can dangerously interfere with lab tests. Doctors say the supplement can distort key blood markers, potentially masking cancer recurrence or delaying treatment decisions.