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Ancient feeding-related neuropeptides regulate alloparenting in ants
Large language models can predict the results of social science experiments
Reinforcement learning control of quantum error correction
Architecture of the 8 MDa Hdr–Vhu–Fwd super-assembly in class I methanogens
Non-genotoxic transplantation and in vivo selection through epitope editing
Single-phase gradient-solvation-electrolyte-stabilized Li metal batteries
In vivo feasibility study of humanoid robots in surgery
Observation of Floquet rotational super-radiance
Nukes in space? Orbital detector could sniff out warheads
How to advance revolutionary science: high turnover, high risk and a licence to fail
Those who forget
I want to see a prison-to-PhD pipeline
Study dampens hope that meningitis vaccine can also prevent gonorrhea
Observational studies suggested the vaccine could do double duty but a randomized trial shows no benefit
A molecular quirk unique to octopuses makes them better at building proteins
Certain shallow-water species carry a mutation that reduces translation errors and prevents toxic protein buildup
Surprising claim of superstringy universe may be based on a mistake
Mix-up in distance scales may explain hints of anisotropy in distribution of galaxies
Springer Nature restores Max Planck’s mysteriously retracted papers
Publisher denies a bot was to blame for withdrawing famed physicist’s work
Scientists found a surprising cancer fighter hiding inside tumors
Scientists at the University of Illinois Chicago have turned an unlikely source into a potential new weapon against cancer: bacteria that naturally live inside tumors. They developed a peptide called aurB, inspired by a bacterial protein, that infiltrates cancer cells and effectively cuts off their energy supply by targeting the mitochondria—the cells’ power plants.
Takeaway meals contain more salt than advertised, study finds
Almost half of the takeaway meals tested contained more salt than advertised, with some dishes delivering nearly twice the recommended daily limit in a single serving. Surprisingly, classic fish and chips ranked among the lowest-salt options, while pasta, pizza, and curries were often the saltiest.
Restoring the balance: Resistance exercise-induced insulin-like growth factor-1 restores PI3K/Akt and MAPK/ERK cross-talk to ameliorate Alzheimer's disease
Alzheimer's disease (AD) remains a progressive neurodegenerative disorder without effective disease-modifying therapies. Epidemiological evidence indicates that regular resistance exercise substantially reduces AD risk, an effect potentially mediated by insulin-like growth factor-1 (IGF-1). However, the complete mechanistic pathway from exercise-induced peripheral IGF-1 synthesis to its central neuroprotective actions has not been systematically integrated. This review provides a comprehensive...
Cryo-EM structure of soluble VPS13C suggests its regulation by a conformational switch and by calmodulin
Bridge-like lipid transfer proteins (BLTPs) play fundamental roles in cellular lipid redistribution between organellar membranes. They comprise bridge domains spanning organelles at contact sites that allow lipids to transit through the cytosol between adjacent membranes. The assembly of BLTPs into complexes with adaptor proteins enables lipid transfer. To address the mechanisms underlying the assembly and regulation of BLTP complexes, we used cryo-EM to resolve the structure of one such BLTP,...