Aggregator
Modulating IL-11-dependent matrix stiffness to delay ovarian aging
Mapping the network architecture of aging to identify repurposable drug candidates for longevity
Targeting interleukin-11 to slow ovarian aging
Author Correction: Synthesis of enantioenriched atropisomers by biocatalytic deracemization
Electrodeposited self-assembled molecules for perovskite photovoltaics
Incoming US science academy chief vows to ‘double down’ on research
Can you actually do a nine-to-five PhD? <i>Nature</i> readers weigh in
A CDK1 phospho-switch reprograms TRAIP to unload replisomes in mitosis
Science, Ahead of Print.
TTF2 processes sites of incomplete DNA replication during mitosis via sister-chromatid exchanges
Science, Ahead of Print.
Manipulation of protein translation and stem cell self-renewal by CRISPR activation of rRNA transcription
Science, Ahead of Print.
Hierarchical sensory processing in zebrafish thalamocortical-like circuits
Science, Ahead of Print.
Being a taller tree doesn’t doom you to drought after all
New study challenges idea that tall trees’ hydraulics make them more vulnerable to dry conditions
Major Ukraine research center damaged in Russian strikes
Damage to century-old Palladin Institute marks “disaster for biological science in Ukraine”
First-ever treatment trial for Ebola Bundibugyo kicks off in the Congo
Scientists will test an antiviral drug and an antibody cocktail designed to tame the burgeoning outbreak
How an ancient continental breakup helped spawn the Antarctic Ice Sheet
Mantle waves and tectonic stretching lofted polar mountains into a deep freeze
A key Arctic science outpost finds itself tangled in a geopolitical web
Svalbard is warming faster than almost anywhere on Earth, but security concerns are tightening access to its glaciers, fjords, and sea floor
Nearly half of kidney transplant patients never even get started
A massive national study found that nearly half of Americans with kidney failure who are referred for a transplant never even begin the evaluation process, and only 19% make it onto the transplant waitlist. Researchers discovered that factors such as where a person lives, whether they are married, their income level, language, age, and even which transplant center they use can dramatically affect their chances of moving forward.
A surprising brain discovery is forcing scientists to rethink movement disorders
A surprising discovery is overturning a long-held assumption about how the brain’s movement center works. Researchers found that two key cerebellar cell types—thought to be tightly linked—often don’t behave in predictable ways, even though one directly influences the other. The finding suggests scientists may have been relying on the wrong signals when studying disorders such as dystonia, ataxia, and tremor.
Recurrent patterns of TOP1-mediated neuronal genomic damage shared by major neurodegenerative disorders
Amyotrophic lateral sclerosis (ALS), frontotemporal dementia (FTD), and Alzheimer's disease (AD) represent two major categories of neurodegenerative disorders-TAR DNA-binding protein 43 (TDP-43) and tau proteinopathies-for which the mechanisms driving neuronal death remain unclear. Single-cell whole-genome sequencing of 469 neurons from C9ORF72 ALS, C9ORF72 FTD, AD, and control brains revealed increased somatic single-nucleotide variants (sSNVs) and insertions/deletions (sIndels) in all three...
Amylin at the crossroads of type 2 diabetes and neurodegenerative diseases
Type 2 diabetes (T2D) is traditionally viewed as a metabolic disease centered on insulin resistance and β-cell failure. However, growing evidence supports its reclassification as a systemic proteinopathy, in which the aggregation of amylin (islet amyloid polypeptide, IAPP) emerges as a key pathogenic event. In this review, we examine the shift toward an IAPP-centric model of disease, highlighting how IAPP misfolding and aggregation drive β-cell dysfunction independently of, and in parallel with,...