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The marine worm’s unusually structured proboscis could inspire future soft-bodied robots

Number of new grants fell by 20%, but got larger, as funder braced for potential budget cut

Impulse control disorders, debilitating non-motor complications of Parkinson's disease, are linked to dopaminergic therapy and mesocorticolimbic dysfunction. This study aimed to characterize cortical sulcal depth, a sensitive morphometric index of cortical folding, and cortical thickness and subcortical volumetric alterations in Parkinson's disease patients with impulse control disorders. Sixty-eight Parkinson's disease patients (30 with impulse control disorders, 38 without impulse control...

Frailty influences the risk, phenotypic expression, and course of highly prevalent neurological conditions. However, the structural, functional, and pathological changes in the brain associated with frailty remain insufficiently explored. This narrative review examines existing evidence on the functional and pathological brain correlates of frailty in both healthy adults and patients with neurological conditions, encompassing findings from neuropathology, fluid biomarkers, neuroimaging, and...

Somatosensory processing has been shown to be correlated with brain development and cognitive function, but whether and how tactile sensory deficits affect cognition decline remains unclear. Here we show that tactile function is impaired in individuals with Alzheimer's disease (AD), and this impairment is inversely correlated with Montreal Cognitive Assessment scores and positively correlated with Tau pathology. We observed similar deficits in presymptomatic 3×Tg AD mice and find that...

CONCLUSION: These results underscore the importance of assessing and addressing perceived risk levels in this population, to promote proactive and effective coping mechanisms. Such efforts may help prevent or delay diabetes-related complications and enhance the quality of life for older adults with type 2 diabetes. Moreover, the findings provide an evidence-based foundation for the development of targeted clinical interventions.

A recent study by Ding et al. harnesses cutting-edge proteomics to explore protein changes linked to human aging over 50 years across 12 tissues and plasma. It uncovered asynchronous aging clocks in different organs, redefining aging as a coordinated, targetable network.

COX7RP is a critical factor that assembles mitochondrial respiratory chain complexes into supercomplexes, which is considered to modulate energy production efficiency. Whether COX7RP contributes to metabolic homeostasis and lifespan remains elusive. We here observed that COX7RP-transgenic (COX7RP-Tg) mice exhibit a phenotype characterized by a significant extension of lifespan. In addition, metabolic alterations were observed in COX7RP-Tg mice, including lower blood glucose levels at 120 min...

Perovskite solar cells (PSCs) based on formamidinium lead iodide (FAPbI₃) demonstrate near-ideal bandgaps approaching the Shockley-Queisser efficiency limit, yet residual MA⁺ from methylammonium chloride (MACl) additives compromises their operational stability under thermal/light stress. Therefore, we developed an α-phase-assisted antisolvent method employing MACl-free precursors to fabricate α-FAPbI(3) films. These films exhibit enhanced thermal stability and structural integrity, which were...