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Adequate protein intake is increasingly recognized as a key determinant of healthy aging, yet its independent and diet-dependent effects on functional decline and mortality remain uncertain. Using data from 532 adults aged ≥65 years in the English Longitudinal Study of Ageing, we examined cross-sectional and longitudinal associations between multiple protein-related parameters and clinical outcomes over six years. We also evaluated whether protein intake modified or mediated the effects of two...

The search for biological mechanisms of human aging is stalled by a lack of suitable models, and it remains unknown whether and to what degree rejuvenation reported in rodents translates to people. Here we report a human induced pluripotent stem cell-derived microphysiological system modelling the white adipose tissue-liver axis in the presence of heterochronic human serum to study aging and rejuvenation in humans. We reveal changes in functional and molecular hallmarks of aging and...

Large-scale gradients of functional connectivity between brain areas organize the human neocortex, linking brain topography to the texture of cognition^(1,2). In adults, three dominant axes-sensory-association, visual-somatosensory and modulation-representation-run, respectively, from primary sensory to transmodal association areas, from visual to body-centred systems and from control and attention networks to default mode and sensory areas^(1-4). These gradients provide a compact description of...

Senescent microglia undergo significant molecular and biochemical changes associated with impaired phagocytosis of amyloid-β (Aβ), a process implicated in neurodegenerative disease progression. However, quantitative biophysical metrics capable of capturing this functional impairment-and thus elucidating the role of microglial dysfunction in disease progression-remain limited. In this study, we identify cellular dry mass, measured by label-free holotomography, in combination with cell and nuclear...

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Brain aging consists of a progressive loss of functional capacities, which is associated with a progressive cognitive decline and can lead to neurodegenerative diseases. Studies comparing the underlying molecular mechanisms of the human hippocampus between young and older adults remain scarce. In our study, we completed a transcriptomic analysis from hippocampal samples of different ages and performed 2 complementary analyses. A comparison between young and old groups revealed a set of genes...

With the number of Parkinson's patients expected to rise due to an aging population, there is an increasing need to identify new diagnostic markers. These markers should be affordable and suitable for routine use to monitor the population, help stratify patients for treatment pathways, and provide new avenues for therapy. Genetic predisposition and familial forms account for approximately 10% of Parkinson's disease (PD) cases, leaving a large fraction of the population with minimal effective...

CONCLUSION: Greater sensorymotor impairment predicts accelerated decline in naturalistic driving among cognitively normal older adults, independent of cognition. A composite SMI may provide a feasible, low-cost approach to identify older drivers at risk for declining mobility and support timely interventions to prolong safe driving.

Science, Volume 391, Issue 6792, March 2026.

Science, Volume 391, Issue 6792, March 2026.

Science, Volume 391, Issue 6792, March 2026.

Science, Volume 391, Issue 6792, March 2026.

Science, Volume 391, Issue 6792, March 2026.

Science, Volume 391, Issue 6792, March 2026.

Science, Volume 391, Issue 6792, March 2026.