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Differential Gene Expression in Human Hippocampus With Aging
Brain aging consists of a progressive loss of functional capacities, which is associated with a progressive cognitive decline and can lead to neurodegenerative diseases. Studies comparing the underlying molecular mechanisms of the human hippocampus between young and older adults remain scarce. In our study, we completed a transcriptomic analysis from hippocampal samples of different ages and performed 2 complementary analyses. A comparison between young and old groups revealed a set of genes...
Machine learning analysis of population-wide plasma proteins identifies hormonal biomarkers of Parkinson's disease
With the number of Parkinson's patients expected to rise due to an aging population, there is an increasing need to identify new diagnostic markers. These markers should be affordable and suitable for routine use to monitor the population, help stratify patients for treatment pathways, and provide new avenues for therapy. Genetic predisposition and familial forms account for approximately 10% of Parkinson's disease (PD) cases, leaving a large fraction of the population with minimal effective...
Naturalistic Driving Outcomes and Sensorimotor Function in Cognitively Normal Older Adults
CONCLUSION: Greater sensorymotor impairment predicts accelerated decline in naturalistic driving among cognitively normal older adults, independent of cognition. A composite SMI may provide a feasible, low-cost approach to identify older drivers at risk for declining mobility and support timely interventions to prolong safe driving.
Daily briefing: Earliest known dog genome pushes genetic record back 5,000 years
Chats with sycophantic AI make you less kind to others
Why labs need a napping room to help you work, rest and play
Trump’s new science advisers include 12 technology chiefs — and one academic
Is astronomy a luxury?
Science, Volume 391, Issue 6792, March 2026.
A genetically encoded device for transcriptome storage in mammalian cells
Science, Volume 391, Issue 6792, March 2026.
Sycophantic AI decreases prosocial intentions and promotes dependence
Science, Volume 391, Issue 6792, March 2026.
Distinctive DNA sequence features define epigenetic longevity of inflammatory memory
Science, Volume 391, Issue 6792, March 2026.
Cryo–electron microscopy structure of the budding yeast telomerase holoenzyme
Science, Volume 391, Issue 6792, March 2026.
Rapid adaptation and extinction in synchronized outdoor evolution experiments of Arabidopsis
Science, Volume 391, Issue 6792, March 2026.
Chromatin buffers torsional stress during transcription
Science, Volume 391, Issue 6792, March 2026.
Family single-cell atlases reveal pig pregnancy and fetal growth restriction critical cell types
Science, Volume 391, Issue 6792, March 2026.
History of ‘forever’ chemicals is written in Antarctic snow
In Science Journals
Science, Volume 391, Issue 6792, Page 1339-1341, March 2026.
A global methane observation system to track climate feedbacks for verifiable climate impact
Science, Volume 391, Issue 6792, Page 1324-1327, March 2026.
Scientists can save nuclear arms control
Science, Volume 391, Issue 6792, Page 1301-1301, March 2026.
Pioneering preprint server goes solo
Science, Volume 391, Issue 6792, Page 1311-1311, March 2026.