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Science, Volume 392, Issue 6796, Page 406-410, April 2026.

Science, Volume 392, Issue 6796, Page 388-394, April 2026.

Science, Volume 392, Issue 6796, Page 429-432, April 2026.

Science, Volume 392, Issue 6796, Page 364-364, April 2026.

Science, Volume 392, Issue 6796, Page 363-363, April 2026.

Long-awaited policy shift could ease barriers for scientists who study the drug

Results are “only the tip of the iceberg” of shadowy paper-mill marketplace

Maturing mouse sperm get loaded with full-length messenger RNAs that are transferred to fertilized egg, suggesting a new route for paternal influence

First treatment for an inherited hearing disorder will be free in the United States

Method that leaches radioactive metal from aquifers can leave groundwater contaminated, researchers say

Giant cephalopods may have rivaled marine reptiles as apex predators during the age of the dinosaurs

Genetically diverse groups arrived in three waves, some potentially carrying genes acquired from long-ago Australasian ancestors

Alzheimer's disease (AD) is a neurodegenerative condition characterized by microglia-mediated neuroinflammation. Deep (>1,000×) panel sequencing of 311 brain samples revealed enrichment of somatic single-nucleotide variants (sSNVs) in cancer driver genes in AD brains, especially in genes associated with clonal hematopoiesis (CH). These sSNVs were associated with clonal expansion and carried by both microglia-like brain macrophages (MLBMs) in multiple brain regions as well as paired blood,...

The molecular basis underlying muscle atrophy, as it occurs during disuse or aging, and activity-induced hypertrophy remain poorly understood. A major challenge has been defining the diverse cellular and niche environments within skeletal muscle, which is mostly composed of multinucleated myofibers. Here, we present a single-nucleus and single-cell transcriptomic atlas, coupled with spatial profiling, of mouse limb skeletal muscle under resting conditions and during experimentally induced...

Understanding aging and complex diseases requires diverse data, ranging from molecular profiles to imaging and routine clinical tests. However, most multi-omic datasets measure only a subset of modalities and are confounded by batch effects. Here, we present AURORA (AI unification and reconstruction of omics reassembly atlas), a generative deep-learning platform that integrates seven modalities (including transcriptomics, metabolomics, microbiome, 3D and thermal facial imaging, and clinical...

Fatty acids (FAs), as the predominant organic acids, form a major component of the metabolome. We present a multi-tiered method that comprehensively captures FA diversity-including chain lengths (C2-C34), unsaturation, isomers, and endogenous forms-within a single biological specimen. This workflow quantifies the broadest range of free FAs reported to date. Integrated with two complementary tiers profiling the total FA pool from alkaline hydrolysis and esterified acyl compositions across lipid...

Frailty is a complex trait that significantly increases the risk for negative health consequences, including hospitalization and disability. However, the evidence regarding the genetic basis of frailty phenotype (FP) is very limited. We conducted a genome-wide association study (GWAS) on FP using the data from the Canadian Longitudinal Study on Aging (CLSA). We classified the participants as non-frail, pre-frail, and frail, and performed a GWAS utilizing the ordinal logistic regression adjusted...

DNA variants modulate mortality risks across an entire lifespan but their dynamic age-dependent effects have not been resolved in any species for either sex. Here we mapped variants that shape mortality using an actuarial approach, starting with a base population of 6,438 pubescent mice and ending with 559 survivors that lived beyond 1,100 days of age. Twenty-nine Vita loci influence lifespan with strong age- and sex-specific effects. Most act during distinct stages with polarities that often...

Cognitive performance prediction may help identify early cognitive decline. However, the heterogeneity of research findings impedes the identification of key predictors. This study used 21,877 participants (25-74 years) from the German National Cohort (NAKO Gesundheitsstudie, NAKO) to systematically predict cognitive test scores based on brain structure, demographic, health-related, and cognitive data. Importantly, validation analyses were performed across study sites and external samples...

De novo lipogenesis (DNL) is a metabolic process by which carbohydrates are converted into fatty acids and used for immediate energy or stored as triglycerides for later use. Increased DNL in brown adipose tissue (BAT) is believed to be a marker of metabolic health, but indicates poor metabolism if upregulated in hepatic tissue. ChREBP is a primary regulator of whole-body DNL and promotes production of key enzymes including fatty acid synthase, acetyl-CoA carboxylase, and stearoyl-CoA...