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Device-independent quantum key distribution over 100 km with single atoms

2 weeks 1 day ago
Science, Volume 391, Issue 6785, Page 592-597, February 2026.
Bo-Wei Lu, Chao-Wei Yang, Run-Qi Wang, Bo-Feng Gao, Yi-Zheng Zhen, Zhen-Gang Wang, Jia-Kai Shi, Zhong-Qi Ren, Thomas A. Hahn, Ernest Y.-Z. Tan, Xiu-Ping Xie, Ming-Yang Zheng, Xiao Jiang, Jun Zhang, Feihu Xu, Qiang Zhang, Xiao-Hui Bao, Jian-Wei Pan

Identification of an engram ensemble mediating memory forgetting in the dentate gyrus

2 weeks 1 day ago
How the memory engram is organized at the cell-assembly level to support not only encoding of learned information but also memory flexibility remains elusive. Here, we propose a novel engram model encoded by two orthogonal learning-recruited neuronal ensembles in the mouse dentate gyrus. Reactivation of the Fos-tagged ensemble promotes memory retrieval, whereas reactivation of the Npas4-dependent ensemble drives forgetting, with manipulation of the forgetting ensemble inversely shifting memory...
Shiqiang Hu

Indigenous gut microbes modulate neural cell state and neurodegenerative disease susceptibility

2 weeks 1 day ago
The native microbiome influences numerous host processes, including neurological function. However, its impacts on diverse brain cell types remain poorly understood. Here, we performed single-nucleus RNA sequencing on the hippocampus of wild-type, germ-free mice, revealing the microbiome-dependent transcriptional landscape across all major neural cell types. We found conserved impacts on key adaptive immune and neurodegenerative transcriptional pathways. Mono-colonization with select indigenous...
Lisa Blackmer-Raynolds

Limitations and opportunities in multi-omics integration for neurodevelopmental, neurodegenerative and psychiatric disorders: A systematic review

2 weeks 1 day ago
Recent advances in high-throughput technologies have led to an increased generation of biological data across genomics, transcriptomics, proteomics, epigenomics, and metabolomics. However, a major challenge remains: effectively integrating these multi-omics datasets to allow a more holistic understanding of the complex, interconnected mechanisms underlying human diseases. Neurodevelopmental, neurodegenerative, and psychiatric disorders are particularly multifactorial and heterogeneous, making...
Luiza Marques Prates Behrens

Injectable hydrogel bioelectrostimulator for wireless deep brain neuromodulation

2 weeks 1 day ago
Deep brain stimulation (DBS) is effective for treating neurological and psychiatric disorders. However, its tethered configuration, invasiveness, and limited tissue compatibility motivate wireless, minimally invasive alternatives. Here, we develop an in situ-gelled injectable conductive hydrogel (ICH), enabling wireless neuromodulation via electric-field localization under volume conduction. The ICH forms in vivo through bio-catalyzed polymerization and electrostatic self-assembly, yielding a...
Ming Yang

Parkinson's disease as a somato-cognitive action network disorder

2 weeks 1 day ago
Parkinson's disease (PD) is an incurable neurological disorder that often begins insidiously with sleep disturbances and somatic symptoms, progressing to whole-body motor and cognitive symptoms^(1-5). Dysfunction of the somato-cognitive action network (SCAN)-which is thought to control action execution^(6,7) by coordinating arousal, organ physiology and whole-body motor plans with behavioural motivation-is a potential contributor to the diverse clinical manifestations of PD. To investigate the...
Jianxun Ren