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Differential Gene Expression in Human Hippocampus With Aging

2 weeks 3 days ago
Brain aging consists of a progressive loss of functional capacities, which is associated with a progressive cognitive decline and can lead to neurodegenerative diseases. Studies comparing the underlying molecular mechanisms of the human hippocampus between young and older adults remain scarce. In our study, we completed a transcriptomic analysis from hippocampal samples of different ages and performed 2 complementary analyses. A comparison between young and old groups revealed a set of genes...
Ander Saenz-Antoñanzas

Machine learning analysis of population-wide plasma proteins identifies hormonal biomarkers of Parkinson's disease

2 weeks 3 days ago
With the number of Parkinson's patients expected to rise due to an aging population, there is an increasing need to identify new diagnostic markers. These markers should be affordable and suitable for routine use to monitor the population, help stratify patients for treatment pathways, and provide new avenues for therapy. Genetic predisposition and familial forms account for approximately 10% of Parkinson's disease (PD) cases, leaving a large fraction of the population with minimal effective...
Fayzan Chaudhry

Chromatin buffers torsional stress during transcription

2 weeks 3 days ago
Science, Volume 391, Issue 6792, March 2026.
Jin Qian, Lucyna Lubkowska, Shuming Zhang, Chuang Tan, Yifeng Hong, Xiaomeng Jia, Robert M. Fulbright, James T. Inman, Taryn M. Kay, Joshua Jeong, Glenn Hauk, Deanna Gotte, James M. Berger, Mikhail Kashlev, Michelle D. Wang

In Science Journals

2 weeks 3 days ago
Science, Volume 391, Issue 6792, Page 1339-1341, March 2026.
Michael Funk, and Di Jiang, Sacha Vignieri, Angela Hessler, Corinne Simonti, Claire Olingy, Allison Williams, Yevgeniya Nusinovich, Ian S. Osborne, Stella M. Hurtley, Mattia Maroso, Peter Stern, Sarah H. Ross, Ekeoma Uzogara, Yury Suleymanov, and John…