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beta-Nicotinamide Mononucleotide Inhibits Cellular Senescence in Mouse C2C12 Skeletal Muscle Cells
β-Nicotinamide mononucleotide (NMN), as the precursor of nicotinamide adenine dinucleotide (NAD^(+)), has remarkable therapeutic potential in aging-associated diseases. Skeletal muscle exhibits not only reduced mass but also impaired strength and function during aging. However, the protective effects of NMN against skeletal muscle cell senescence remain to be fully elucidated. In this study, we used D-galactose (D-gal) to establish a senescence model in C2C12 cells. Our results demonstrate that...
The Role of EVs in the Aging Hematopoietic System
Extracellular vesicles (EVs) are membrane-enclosed nanoparticles that mediate intercellular communication by transferring proteins, nucleic acids, and lipids. Within the hematopoietic system, EVs orchestrate critical signaling between bone marrow (BM) niche cells and hematopoietic stem and progenitor cells (HSPCs) to regulate quiescence, proliferation, and lineage commitment. During aging, senescence and telomere attrition drive a profound remodeling of EV biogenesis and cargo. Aged EVs,...
Mapping the Landscape of AgeTech Standards and Guidelines: A Gray Literature Review
CONCLUSIONS: Although AgeTech standardization is advancing, critical gaps remain. Limited attention to safety, security, privacy, and digital economy and community inclusion raises concerns for trust, equity, and sustainable adoption. Addressing these gaps through targeted and coordinated standardization efforts is essential to support inclusive, trustworthy, and scalable AgeTech solutions in the context of rapid global population aging.
Daily briefing: Will AI really be the death of us all?
A cross-species single-cell kidney epigenome atlas reveals epithelial-dominant aging-like states in disease
Multi-modality profiling identifies <i>Neisseria flavescens</i> as a central geroprotective oral commensal in humans
Publisher Correction: Physical activity delays ovarian aging in part through adiponectin-related signaling pathways
GLP-1 drugs fail to help some people lose weight — scientists are on a quest for answers
AlphaFold ‘goes viral’: database adds protein complexes of common viruses
AI agent hacks government website for first time: why this breach matters
AI system helps lab devices ‘talk’ with each other — streamlining research
Youthful fans of YouTube sports videos stick to the sofa
Bumblebees don’t mind a little plastic in their honeypots
Verification makes discovery matter
Science, Ahead of Print.
In-cell structures visualize human pre-ribosome assembly in the nucleolus
Science, Ahead of Print.
Stereodivergent telomerization of linear functionalized dienes with amines
Science, Ahead of Print.
Antiferroelectric hafnia down to the 2D limit
Science, Ahead of Print.
More REM sleep linked to lower risk of 83 diseases
A large study tracking more than 95,000 people suggests that how you sleep may be linked to your risk of developing dozens of diseases. People who spent more time in REM sleep had lower risks of 83 conditions, including dementia, heart failure, and Parkinson’s disease, while more deep sleep was associated with lower risks of conditions such as type 2 diabetes and major depression.
GLP-1 weight loss and diabetes drugs linked to nutritional deficiencies in nearly 1 in 6 children
Children taking GLP-1 medications (such as Victoza, Saxenda, Trulicity, and Ozempic) for weight loss, prediabetes, or type 2 diabetes may face an overlooked risk: nutritional deficiencies. A new study found that nearly 1 in 6 young patients developed a diagnosed deficiency within a year of starting treatment, with vitamin D deficiency affecting about 12%.
Little-known arm of immune system could be key to better vaccines, cancer therapies
The CD1 system responds to lipids, not proteins, driving reactions to bee stings, bacteria, and possibly poison ivy