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Reversing prediabetes cuts risk of deadly heart problems by 58%

2 weeks 2 days ago
Bringing blood sugar levels back to normal may dramatically reduce the danger posed by prediabetes. Researchers found that people who reversed prediabetes cut their risk of cardiovascular death or hospitalization for heart failure by 58% and lowered their chances of major heart problems such as heart attacks and strokes by 42%. The benefits lasted for decades and were seen across large long-term studies in both the U.S. and China.

Cellular senescence in ischemic stroke: Cell-type specificity, temporal dynamics, and response to therapeutic interventions

2 weeks 2 days ago
Increasing experimental and clinical evidence indicates activation of cellular programs resembling senescence and senescence-associated secretory phenotype signaling after stroke. However, a central challenge is definitional: in injured brain tissue, many senescence-associated features overlap with acute stress responses, transient cell-cycle perturbations, and reactive glial or vascular programs, complicating interpretation across models, time points, and cell types. Here, we synthesize the...
Xiaolong Liu

Nacre extract attenuates age-related functional and tissue alterations under post-onset intervention conditions in two murine aging models

2 weeks 2 days ago
Aging is accompanied by the accumulation of senescent cells and chronic low-grade inflammation, which together contribute to functional decline and tissue remodeling across organs. We previously reported that long-term nacre extract supplementation can delay age-related deterioration when initiated early; however, whether it can provide benefit under post-onset intervention conditions remains unclear. Here, we evaluated a water-soluble nacre extract derived from Pinctada fucata using (i)...
Momoko Kawaminami

Awareness of active ageing and its association with quality of life among older adults in a tertiary care setting in Saudi Arabia: a cross-sectional study

2 weeks 2 days ago
CONCLUSIONS: The study findings showed a low level of awareness of the concept of active ageing among older adults in a tertiary care clinic in Saudi Arabia. Greater awareness of active ageing was positively associated with better quality of life among older adults, despite limited familiarity with the concept. These findings highlight the importance of integrating active ageing education into healthcare services and public health initiatives to support healthier and more fulfilling ageing...
Halah F Alenizi

Scientists found a surprising problem with sugar-free diets

2 weeks 2 days ago
A surprising new study suggests that completely eliminating sugar may backfire. Mice on a sucrose-free low-fat diet showed worse blood sugar control, increased inflammation, disrupted gut bacteria, and signs of fatty liver compared with mice that consumed some sucrose. Researchers say the results highlight the importance of a balanced diet and a healthy gut microbiome rather than focusing solely on cutting out sugar.