Aggregator

Regenerative capacity varies widely across animals, yet aging is often accompanied by declining tissue homeostasis and regenerative potential. In many species, regeneration of complex structures relies on epimorphic programs that form a blastema, coordinating cell proliferation and pattern reorganization after injury. Although aging-associated regeneration defects have been documented in several bilaterian models, how aging shapes regeneration in early-branching metazoans with robust...

Aging exacerbates the incidence of discogenic chronic low back pain by excessive inflammation and immune cell presence. Aging reduces intervertebral disc (IVD) Wnt signaling, which is associated with IVD cell differentiation, IVD cell proliferation and anti-inflammatory signaling. However, it is unclear how in vivo Wnt signaling-absent IVD cells, which model aged IVD cells, regulate chemotactic signaling and immune cell recruitment. We hypothesized that Wnt signaling-absent IVD cells attenuate...

Ageing biomarkers quantify molecular, physiological or functional features that vary between individuals as they age and may improve prediction of health outcomes beyond chronological age. Recently, plasma proteomics have been used to estimate the biological ages of 11 human organs. Although accelerated organ ageing is associated with higher mortality risk, systematic benchmarking against established ageing biomarkers is lacking. Here, we pursued two complementary aims. First, we benchmarked...

Strength training may be one of the most powerful tools for staying independent as you age. Age related muscle loss, known as sarcopenia, can make everyday tasks harder while increasing the risk of falls, fractures, and loss of mobility. Research shows that resistance exercises such as squats, weights, resistance bands, and even body weight movements can preserve or rebuild strength, and surprisingly, even one session a week can produce meaningful benefits.

Major discoveries, including the role of DNA, the biological basis of psychology, and the human genome, missed out on science’s top recognition

Scientists welcome new money but remain cautious about weakening environmental protections

To get to the bottom of this perplexing behavior, Science interviewed the agent

Weak sunlight can still damage skin DNA if you spend enough time outdoors, according to a landmark Australian study. Even UV doses too low to cause visible redness triggered cellular damage that could accumulate over time and contribute to skin cancer risk.

Scientists found that five seemingly unrelated conditions, including long Covid, ME/CFS, and PTSD, may disrupt many of the same biological networks involved in immunity, metabolism, and cellular energy. The findings could help explain their shared symptoms and may open the door to new blood tests and treatments.

People who followed the MIND diet more closely showed slower brain shrinkage and less grey matter loss over time, with the strongest differences equivalent to about 2.5 years of delayed brain aging. Berries and poultry were linked with healthier brain changes, while sweets and fried fast foods were associated with greater tissue loss.