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Non-invasive ovulation tracking enables genetic engineering in wild rodents
Many non-model rodent species are inaccessible to genetic engineering due to our limited understanding of their reproductive biology. Here, we present a low-cost, camera-based estrous-tracking technology that enables transgenesis in the white-footed mouse Peromyscus leucopus, a key reservoir for Lyme disease. We demonstrate the efficient generation of pregnant and pseudopregnant mice via timed ovulation, provide protocols for embryo generation, cultivation, microinjection, and transplantation as...
Deletion of Mfn2 in endothelial cells triggers a mitohormetic response that improves systemic metabolism and healthspan in mice
Endothelial cells (ECs) are key metabolic gatekeepers, yet their role in metabolic health remains unclear. Given their central involvement in energy metabolism, mitochondria are ideally positioned to enable ECs to adapt to ever-changing metabolic requirements. Here, we explore the hypothesis that mitochondrial dynamics proteins in ECs influence whole-body metabolic status. Genetic deficiency of Mfn2 in ECs (Mfn2^(iΔEC)), but not of Mfn1^(iΔEC), induces a mitohormetic response in the adipose...
Which aspects of the everyday behavior of older dogs correlate with performance on a visuo-spatial memory test and the canine cognitive dysfunction rating scale (CCDR)?
The behavioral aspects of aging in the domestic dog have primarily been investigated through owner-reported scales that measure specific behavioral signs of aging, and laboratory-based memory and cognitive tests. We need to know more about how aging affects everyday behavior and functionality in owned dogs. This study tested a methodology for identifying patterns in everyday physical and behavioral function associated with behavioral tests and scales. Fifty-seven family dogs aged 8+ years were...
Scientists decry Trump’s rush to loosen radiation exposure standards
White House push to boost nuclear power could lead to more cancer cases, some researchers say
Daily briefing: Automated robot ‘scientists’ spark debate over the future of lab work
‘Universal vaccine’ protects mice against multiple pathogens
Blood test holds promise for predicting when Alzheimer’s symptoms will start
Biotech investor set to lead US National Science Foundation
Host control of persistent Epstein–Barr virus infection
Visceral adiposity, metabolic health and aging
Leaving WHO does not serve America’s—or the world’s—best interests
Science, Volume 391, Issue 6787, February 2026.
The functional landscape of coding variation in the familial hypercholesterolemia gene LDLR
Science, Volume 391, Issue 6787, February 2026.
A whole-brain single-cell atlas of circadian neural activity in mice
Science, Volume 391, Issue 6787, February 2026.
Carbonated ultramafic igneous rocks in Jezero crater, Mars
Science, Volume 391, Issue 6787, February 2026.
Scimitar-crested Spinosaurus species from the Sahara caps stepwise spinosaurid radiation
Science, Volume 391, Issue 6787, February 2026.
Implanted flexible electronics reveal principles of human islet cell electrical maturation
Science, Volume 391, Issue 6787, February 2026.
Termination of the integrated stress response
Science, Volume 391, Issue 6787, February 2026.
Ribosomal RNA expansion segments mediate the oligomerization of inactive animal ribosomes
Science, Volume 391, Issue 6787, February 2026.