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How an exercise-activated enzyme helps to keep the brain young
The surprising science of squeaky sneakers
Reply to: Limitations of probing field-induced response with STM
OMICmAge quantifies biological age by integrating multi-omics with electronic medical records
Five ways to spot when a paper is a fraud
<b>What's the best way to change research fields? These three scientists have ideas</b>
The first ice-core record of historical atmospheric hydrogen levels
The future perfect continuous passive and other transitive disorders of the mind
The age of animal experiments is waning. Where will science go next?
EU leaders should not rush to revamp green-hydrogen rules
Pop-up journals for policy research: can temporary titles deliver answers?
Moon’s ancient magnetic field may have flickered on and off
Billions of years ago, melting rocks deep inside the Moon could have led to bursts of surprisingly strong magnetism
Censorship and safety concerns cloud China’s plans to host science journalism conference
Organizers of the 2029 World Conference of Science Journalists defend Beijing meeting as opportunity to connect with Chinese scientists
U.S. science agency moves to restrict foreign scientists from its labs
Proposed rule at National Institute of Standards and Technology would limit access to a few years for international researchers and students
A lineage-specific selective autophagy receptor module mediates P-body turnover
Processing bodies (P-bodies) are conserved ribonucleoprotein granules central to RNA metabolism across eukaryotes. Although the mechanisms underlying their assembly are well understood, the pathways governing their selective turnover remain unclear. Here, we identify the conserved decapping proteins Enhancer of mRNA decapping 4 (EDC4) and decapping protein 1 (DCP1) as a selective autophagy receptor pair responsible for P-body turnover in the model plant Marchantia polymorpha. MpEDC4 engages ATG8...
China is waging war on Alzheimer's. What can its approach teach the rest of the world?
No abstract
DNA-PK-mediated phosphorylation of STAT6 establishes a non-canonical type 2 immunity axis to prevent macrophage senescence
Macrophage senescence drives inflammaging, a chronic, age-related inflammation. To date, the protective mechanisms against inflammaging are poorly defined. Here, we identify DNA-PK-mediated phosphorylation of murine STAT6 at serine 807 (Ser807) as a crucial post-translational modification for preventing macrophage senescence. Ser807 phosphorylation blocks STAT6 ubiquitination-mediated degradation and promotes STAT6 partnering with PU.1 to activate DNA repair genes. Macrophages lacking Ser807...
Metabolic quiescence of naive-like memory T cells precedes and maintains antigen-specific T cell memory
Metabolic activity shapes cell fate but remains challenging to capture in vivo with high resolution. Here we performed longitudinal metabolic and phenotypic profiling of human antigen-specific CD8^(+) T cells after yellow fever vaccination using flow cytometry and single-cell RNA sequencing. As assessed by protein translation rates, CD8^(+) T cells upregulated glycolysis to fuel anabolic needs for proliferation but predominantly used oxidative phosphorylation for energy production during the...
Senescence at the crossroads of postpartum remodeling and tumorigenesis
No abstract
Heart rate variability to objectively measure fear of falling in post fall patients: a protocol study
No abstract