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Labor is mediated proximately by prostaglandin signaling within gestational tissues and must be tightly regulated for birth to occur after appropriate fetal development. Metabolic changes accompanying gestational aging have been postulated as a determinant of birth timing, but specific nutrients, sensors, and messengers remain obscure. We report that placental nicotinamide adenine dinucleotide (NAD^(+)) dynamically tunes gestational length. Depletion of placental NAD^(+) in mice provoked labor...

CONCLUSIONS: The findings suggest that limited uptake of digital elder care is closely tied to moral legitimacy and ethical recognition. Digital care services are more likely to be accepted when perceived as a supportive extension of, rather than a replacement for, family care responsibilities. Addressing ethical lag through culturally resonant service design and trusted community mediation may help reduce inequalities in engagement and improve the effectiveness of ageing-related service...

After clearing a spring forecasting hurdle, scientists see growing odds of a powerful climate event that could disrupt weather worldwide

Researchers discovered that declining levels of phosphatidylcholine may be a major cause of age-related mitochondrial dysfunction and loss of cellular energy. Remarkably, boosting this nutrient restored more youthful mitochondrial performance in aging organisms, suggesting some aspects of aging can be slowed or reversed.

Science, Ahead of Print.

Science, Ahead of Print.

The government has tasked a group of scientists with assessing new technologies for “sustainable” oil and gas drilling—but many experts say it’s a fantasy

Understanding how the first patient became infected may shed new light on Andes virus’ transmission patterns and incubation period

Goblin sharks have never before been filmed in their natural habitat

Enhanced cryo–electron microscopy promises to bring previously elusive proteins into view

Studies of the Atlantic's circulation find signs of both weakening and unexpected stability in the face of global warming