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Science, Ahead of Print.

Scientists created smart nanoparticles that can both illuminate hidden glioblastoma cells during surgery and destroy microscopic cancer left behind afterward. In mice, the treatment prevented recurrence and led to 100% survival at 60 days, though it has not yet been tested in humans.

Researchers discovered a brain-based “brake” that can shut down chronic nerve pain in mice by calming an overactive pain circuit. Targeting this system more precisely could one day lead to powerful pain relief without affecting opioid receptors throughout the entire body.

Discovery in hamsters suggests path toward inducing hibernation in mammals that don’t do it naturally

1000-year archive from the Galápagos portends greater weather disruptions from the Pacific climate cycle

Maturing techniques and cheaper launches fuel microgravity research—and hopes of orbital manufacturing

Moderate calorie restriction lowered an immune protein called C3 that appears to help drive chronic inflammation as the body ages. Blocking the same protein reduced age related inflammation in mice, raising the possibility that future treatments could mimic some benefits of calorie restriction without severe dieting.

A startling study suggests at least one in four NFL players develops CTE, but doctors still can’t identify it in living athletes

Britain’s postwar sugar rationing created a rare natural experiment that let researchers examine how early sugar exposure might affect health decades later. People who experienced more rationing during their first 1,000 days had lower rates of several cancers and showed signs of slower biological aging. They were also still eating less sugar and maintaining healthier diets around age 50.

Water droplets sliding across surfaces can gain enough static electricity to break down anticorrosion coatings

Previously collected fossils prove a treasure trove for understanding the origin of insects

A compound found in turmeric may help protect blood vessels from some of the damage caused by Type 1 diabetes. In rats, curcumin reduced inflammation, improved cellular signaling, and restored vascular health to levels resembling those of nondiabetic animals. The results hint at a possible new way to reduce the long-term cardiovascular risks of diabetes, but human trials are still needed.

Neuroinflammation and synapse loss are associated with cognitive decline in Alzheimer's disease (AD). Although microglial hyperphagocytic activity has been implicated in synapse loss^(1-4), the mechanisms underlying these pathologies remain obscure. Here we demonstrate that, during AD progression in mice, astrocytes and microglia increase phagocytic elimination of excitatory synapses while reducing elimination of inhibitory synapses, suggesting that neuroinflammation alone may be dispensable for...

The GoDig platform enables sensitive, multiplexed targeted pathway proteomics without manual scheduling or synthetic standards. Here we present GoDig 2.0, which increases sample multiplexing to 35-fold, improves time efficiency and reduces scan delays for higher success rates, and allows flexible spectral and elution library generation from different mass spectrometry data types. GoDig 2.0 measures 2.4× more targets than GoDig 1.0, quantifying >99% of 800 peptides in a single run. We compile a...

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