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Engineering chronological lifespan toward a robust yeast cell factory

2 weeks 1 day ago
Metabolic rewiring helps to construct efficient microbial cell factories; however, these cells suffer from metabolic stress during long-term fed-batch fermentation. Thus, the construction of robust cells is vital for industrial application of microbial cell factories at the laboratory scale. Here, we systematically characterized longevity factors and pathways for biosynthesis of the diterpenoid sclareol and found that weakening nutrient-sensing pathways and enhancing mitophagy synergistically...
Zulin Wu

Neither inaccurate nor biased in later life: Age-related differences in the accuracy and bias of facial trustworthiness judgment

2 weeks 1 day ago
People tend to form impressions of others' trustworthiness based on their facial appearance and make trust-related decisions accordingly. In such face-based trustworthiness judgments (FBTJs), older adults are generally more likely than younger adults to attribute higher trustworthiness. This pattern is sometimes referred to as positivity bias and has been proposed as a potential risk factor for fraud victimization in later life. However, previous studies lack objective ground-truth measures of...
Atsunobu Suzuki