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Asymmetric selection of a rice immune module and rebuild of disease resistance
Clinical application of base editing for treating β-thalassaemia
Mummified early Permian reptile reveals ancient amniote breathing apparatus
Genetic predictors of GLP1 receptor agonist weight loss and side effects
High-precision measurement of the W boson mass with the CMS experiment
Single-cell spatiotemporal dissection of the human maternal–fetal interface
High-fidelity collisional quantum gates with fermionic atoms
DNA damage drives antigen diversification in <i>Trypanosoma brucei</i>
The importance of competition and facilitation for global tree diversity
Saturation editing of <i>RNU4-2</i> reveals distinct dominant and recessive disorders
Protected quantum gates using qubit doublons in dynamical optical lattices
Biodiversity resilience in a tropical rainforest
Engineered immunosuppressive dendritic cells protect against cardiac remodelling
High-precision calculation of the quark–gluon coupling from lattice QCD
Briefing Chat: The tongue trick that helps sunbirds suck
Author Correction: Foundation model of neural activity predicts response to new stimulus types
Author Correction: Oncogene ablation-resistant pancreatic cancer cells depend on mitochondrial function
Growth hormone-releasing hormone attenuates amyloid deposition and neuroinflammation in Alzheimer's disease models
Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by amyloid-β (Aβ) accumulation, tau hyperphosphorylation, neuroinflammation, and synaptic loss. Existing therapies provide only modest symptomatic relief and fail to slow disease progression. Beyond its role in promoting pituitary growth hormone (GH) secretion, growth hormone-releasing hormone (GHRH) has shown neuroprotective effects in experimental ischemic stroke and spinal muscular atrophy. Here, we explored...
The potential of low-field MRI for global dementia care
With elderly populations increasing in many countries, rates of Alzheimer disease and related dementias (ADRD) are expected to rise worldwide in the coming years. Low-income and middle-income countries, where barriers to health care are most pronounced and research representation is limited, are predicted to experience the greatest increases in ADRD prevalence. Access to advanced diagnostic and research tools, such as neuroimaging, is severely restricted in these regions, but low-field MRI is...
Don't rush use of lymphatic surgery in Alzheimer's disease
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