Aggregator
A Primate-Specific lncRNA LINC01021 Contributes to Cellular and Organismal Aging via DAZAP1-Dependent Destabilization of RBMX
Aging is characterized by progressive physiological decline and age-related pathologies, yet the molecular determinants underlying lineage- and species-specific aging traits remain poorly understood. Although protein-coding regulators have dominated aging research, the contribution of long non-coding RNAs (lncRNAs), particularly primate-specific lncRNAs, has not been systematically explored. Here, through evolutionary screening and cross-species aging-associated analyses, we identified a set of...
Robust and sensitive ELISA detection of total and activated PRKN
Parkinson disease (PD) is closely linked to disruptions in mitochondrial quality control, a process regulated by the ubiquitin kinase PINK1 and the E3 ubiquitin ligase PRKN/parkin. Upon mitochondrial damage, PINK1 phosphorylates ubiquitin, which in turn recruits and activates PRKN. Full activation of PRKN is mediated by PINK1-dependent phosphorylation of PRKN at serine 65, which leads to widespread ubiquitination of mitochondrial substrates and amplifies the mitophagy response. Disruption of...
Preserving togetherness or ensuring safety? The dilemma of where to live and receive dementia care
CONCLUSION: The described barriers contributed to fears of losing personal identity, daily habits, and (culturally) meaningful ways of being. The findings highlight the need for stakeholders and policymakers to address these vulnerabilities when developing healthcare and social services for immigrants living with dementia.
The association between unfinished care and risk of burnout in nursing homes and the moderating role of managerial support - a cross-sectional multicenter study
CONCLUSION: Our findings underscore the importance of minimizing unfinished care, as it is regarded as an indicator of quality, and is significantly associated with all dimensions of risk of burnout. Managerial support appears to act as a buffer in this association, with unfavorable support exacerbating the effects, particularly with regard to depersonalization. Conversely, these effects are attenuated when care workers perceive their manager as supportive, emphasizing the value of supportive...
Robust and sensitive ELISA detection of total and activated PRKN
Parkinson disease (PD) is closely linked to disruptions in mitochondrial quality control, a process regulated by the ubiquitin kinase PINK1 and the E3 ubiquitin ligase PRKN/parkin. Upon mitochondrial damage, PINK1 phosphorylates ubiquitin, which in turn recruits and activates PRKN. Full activation of PRKN is mediated by PINK1-dependent phosphorylation of PRKN at serine 65, which leads to widespread ubiquitination of mitochondrial substrates and amplifies the mitophagy response. Disruption of...
Daily briefing: Humans and great apes giggle in the same rhythms
‘Edited’ human embryos reveal secrets of our development — and fuel ethical debate
Electric fields probe the symmetry of the ‘heavy hydrogen’ nucleus
Can you terraform Mars? Try <i>Nature</i>’s game
China’s LineShine just topped the global supercomputer ranking: what you need to know
US funding uncertainties threaten to sink key global oceanography projects
Oo oo, ha ha: why humans and great apes giggle alike when tickled
Base editing reveals an essential role for NANOG in human embryogenesis
Ligand-enabled distal desaturative lactonization of aliphatic acids
Publisher Correction: In situ nanocrystal confinement for efficient blue perovskite LEDs
How long-term dietary cholesterol can slow down its own clearance by liver cells
The origin, history, and resistance architecture of an invasive urban malaria mosquito in Africa
Science, Ahead of Print.
Constraining an exoplanet’s magnetic field using star-planet interactions
Science, Ahead of Print.
Cyclic sealing and drainage on an oceanic transform fault
Science, Ahead of Print.
Osteopenia is silently weakening bones in millions of people
Osteopenia is a common but often overlooked condition that causes bones to become less dense and more fragile. Because it develops silently, many people only discover they have it after a fracture or bone scan. Aging, menopause, poor diet, and inactivity can all contribute to bone loss. Fortunately, exercise, adequate calcium and vitamin D, and other healthy habits can slow or even partially reverse the decline.