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Broadly stable atmospheric CO<sub>2</sub> and CH<sub>4</sub> levels over the past 3 million years
Adaptive evolution of gene regulatory networks in mammalian neocortex
Thymic health consequences in adults
Observing the tidal pulse of rivers from wide-swath satellite altimetry
Synthetic circuits for cell ratio control
In vivo site-specific engineering to reprogram T cells
Magnetic resonance control of spin-correlated radical pair dynamics in vivo
Integrated memristor for mitigating reverse-bias in perovskite solar cells
Botanical mystery solved: how plants make a crucial malaria drug
Affordable mobility for all: why we need smaller, cheaper electric vehicles
AI set to map risks of future climate disasters
Major Turing computing award goes to quantum science for first time
Publisher Correction: Atlas-guided discovery of transcription factors for T cell programming
Author Correction: Autoimmune response to C9orf72 protein in amyotrophic lateral sclerosis
Knock knock, no one’s there. Study finds scientists’ jokes mostly fall flat
ArXiv, the pioneering preprint server, declares independence from Cornell
As an independent nonprofit, it hopes to raise funds to cope with exploding submissions and “AI slop”
Computer science’s ‘Nobel Prize’ goes quantum
Charles Bennett and Gilles Brassard share this year’s $1 million A.M. Turing Award for work on quantum information
China demands evidence that traditional medicine injections really work
New regulations ask manufacturers to provide efficacy and safety data—or withdraw their products
ATP13A2 restrains macrophage NLRP3 inflammasome activation to repress neurodegeneration via modulating mitochondrial homeostasis
Neuro-immune crosstalk is increasingly recognized in Parkinson's disease (PD), and ATP13A2 is well known for its neuroprotective role. However, it remains unclear whether ATP13A2 mutations carried by PD patients contribute to immune dysfunction that exacerbates disease progression. Here, we systematically demonstrate that many ATP13A2 mutations result in a loss-of-expression phenotype. ATP13A2 is highly expressed in macrophages. Myeloid ATP13A2 deficiency causes uncontrolled NLRP3 inflammasome...
Astaxanthin, meclizine, mitoglitazone, pioglitazone, alpha-ketoglutarate, mifepristone, methotrexate, and atorvastatin-telmisartan do not increase lifespan in UM-HET3 mice
The Interventions Testing Program (ITP) evaluated eleven compounds in genetically heterogeneous UM-HET3 mice to assess their potential to extend lifespan. These interventions included both novel agents and previously tested compounds administered at novel doses or starting ages. Despite prior evidence suggesting lifespan benefits of these proposed interventions in other models or under different conditions, none of the tested compounds significantly increased lifespan in male or female mice....