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CONCLUSION: These findings identify gaze fixation as a key determinant of increased spin-turn use during turning in older adults, whereby constraining gaze to the near walking surface alters visual information available for step planning and promotes maladaptive turning strategy selection.

Frequently ignored bodily rhythms may be skewing neuroscience experiments

Substance’s “remarkable” behavior could lead to devices powered by energy-rich gels

A new biomaterial made from jackfruit latex, pomegranate peel, and simvastatin could transform the treatment of severe gum disease. Early tests suggest it not only combats infection and inflammation but may also help rebuild lost bone and tissue around teeth.

Scientists may have uncovered a hidden trigger behind Alzheimer’s disease. Instead of plaques being the root cause, amyloid beta appears to interfere with tau, a protein that helps keep neurons functioning properly. This disruption could set off the damage that eventually leads to the disease’s most recognizable brain changes.

Plague was already a deadly killer 5,500 years ago, long before cities, farming, or the rat-infested conditions usually linked to historic outbreaks. By analyzing ancient DNA from hunter-gatherer cemeteries in Siberia, researchers discovered early plague strains in nearly 40% of the individuals studied and found evidence of rapid family-based outbreaks that wiped out many children and young teenagers.

In this issue of Molecular Cell, Sohn et al.¹ explore how endogenous dsRNAs influence organismal aging and identify an unexpected function of the aminoacyl-tRNA synthetase FARS-1/FARSA in regulating mitochondrial dsRNA homeostasis to balance longevity and innate immunity.

Increasing evidence suggests that epigenetic dysregulation is both a hallmark and a potential driving force of aging. As a multifactorial, non-linear, and systemic biological process, aging likely results from a progressive imbalance in a complex epigenetic network involving DNA, histones, RNA, and non-coding sequences. These interconnected alterations collectively lead to core aging features such as genomic instability, heightened inflammation, and loss of cellular identity. In this review, we...

CONCLUSIONS: Cardiometabolic biomarker domains, particularly glycaemic dysfunction, were reproducibly associated with incident mobility limitation. A simple biomarker-burden score captured a relevant but incomplete component of functional ageing risk.

Obesity increases the risk of common diseases and mortality, placing a significant burden on our aging society. Bariatric surgery results in significant weight loss; however, the amount of associated health gain is currently less studied, particularly in the first two years. We modelled mortality-associated biological age according to established blood markers in a prospective cohort of 505 patients that underwent bariatric surgery. The difference between biological age and chronological age...

Cellular senescence is a highly heterogeneous state of cell stress response that deleteriously accumulates with age and contributes to age-related dysfunction. While the heterogeneity across cell types is well documented, variation within the same cell type is only beginning to be understood. Here, we show primary human lung fibroblasts from either donors who are healthy or diagnosed with idiopathic pulmonary fibrosis (IPF) exhibit a subtle form of heterogeneity over time after DNA damage....

Hippocampal volume is associated with memory and is critical in Alzheimer's disease, but few studies have examined hippocampal subfield volume changes during healthy aging. Herein, we utilize submillimeter MRI to examine age- and sex-specific subfield volumetric changes in 206 participants (M(age) = 53.05 years, range = 21-87, N(female) = 110). Total intracranial volume was regressed out and hierarchical regression was performed to examine subfield volume changes with age. To identify inflection...

Radiotherapy (RT) efficacy is limited by RT-induced immune resistance. Here we show that RT upregulates programmed death ligand 1 (PD-L1) on senescent tumor cells (STCs) via bromodomain-containing protein 4 (BRD4) signaling, thereby promoting immune evasion. To counter this, we develop POLY-Senolytic, a polymeric senolytic nanoparticle formed by conjugating an acid-responsive polymer to a peptide-based BRD4 PROteolysis-TArgeting Chimera via a reduction-cleavable disulfide bond. The...

Life is a constant struggle against disorder. As we age, our ability to maintain internal order declines. In the healthy human brain, order is observable in the form of functionally segregated brain network communities that exhibit spatial consistency. These communities associate with distinct cognitive and physical functions. When mapped into the brain, they form a functional "landscape". We assessed the spatial disorder of these landscapes in older adults with a wide range of mobility using a...