Aggregator

CONCLUSION: This external pilot showed no superiority of CO-OP plus creative dance over CO-OP alone for the prespecified primary outcome (executive function). Preliminary signals for global cognition and dual-task accuracy warrant confirmation in an adequately powered definitive trial with a prespecified, clinically meaningful primary endpoint.

CONCLUSION: Approximately one-third of older adults had problematic-limited / inadequate health literacy. An independent association was observed between limited HL and a higher probability of being physically inactive. However, health literacy was not independently related to smoking. These findings imply that health literacy may be an important factor underlying differences in physical activity engagement among older adults. Community-based strategies integrating health literacy support and...

CONCLUSIONS: We found that although living alone is associated with mortality, adjustment for social and functional factors may attenuate this association. However, specific subgroups with low income, and scarce social relation lead to increased CCV mortality. Further study with a larger sample size is necessary to confirm this finding.

CONCLUSIONS: This multi-cohort integrative study defines the cellular and clonal signatures of latent CMV in humans and identifies GZMK⁺ CD8⁺ T cells and Th1 cells as previously underappreciated components of the CMV response.

CONCLUSIONS: The findings suggest that healthy ageing in this sample was characterized by multidimensional, heterogeneous and interrelated profiles rather than residential status alone. Functional movement quality and environmental engagement were associated with several healthy ageing indicators, but causal mechanisms cannot be inferred. The results should be interpreted as exploratory and hypothesis-generating, warranting confirmation in larger longitudinal and intervention studies.

NIH’s arguments opposing the union don’t hold up, ruled a federal entity that oversees labor relations

Exercise triggers bone cells called osteocytes to secrete antiaging chemicals in mice

A surprising discovery at UC San Diego suggests that chronic lower back pain may become deeply embedded in the brain's sense of personal identity. Researchers found that movement-triggered pain activates a brain network associated with self-awareness and memories, even though ordinary acute pain typically shuts this network down. This unexpected difference could explain why conventional pain medications often provide limited relief and why fear, anticipation, and past experiences can intensify chronic pain.

Scientists have identified a weakened brain signal that may connect several seemingly unrelated symptoms of schizophrenia, including sensory processing difficulties, disorganized speech, and greater symptom severity. The surprising discovery could help explain the disorder's underlying mechanisms and potentially lead to earlier detection and new treatments.

A study of nearly 13,000 adults found that people consuming the most artificial sweeteners experienced a 62% faster decline in memory and thinking skills, equivalent to approximately 1.6 additional years of brain aging. Six popular sweeteners were linked to faster cognitive decline, raising concerns about the long-term brain health effects of common sugar substitutes, although causation was not established.

Rules governing credit and responsibility for machine-written papers may need a reboot

Getting more daylight could be linked to a surprisingly powerful benefit for brain health. In a study of more than 87,000 adults, researchers found that higher daytime light exposure was associated with a 16% lower risk of dementia, with longer exposure to bright light linked to even greater reductions. Remarkably, getting less than 42 minutes of bright daylight daily was a stronger predictor of dementia than six established risk factors.