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Falls in older adults result from declines in muscle quality. This study aimed to examine differences in load-velocity profile (LVP) metrics, muscle ultrasound measures, strength, functional tests, and lifestyle between older adults with and without falls, and to analyze their association with sit-to-stand power. Sixty-two older adults (41 non-fallers, 21 fallers; mean age 68.32 ± 5.07 years) underwent three lab sessions. LVP was determined via functional electromechanical dynamometry during a...

Sleep disturbances and Alzheimer's disease (AD) are interconnected public health challenges. However, the underlying mechanisms of their complex relationships remain elusive. Here, we propose a hypothetical integrative, stream-like model outlining how external and internal exposome factors accelerate brain aging, thereby exacerbating circadian dysregulation, orexin-mediated hyperexcitability, metabolic imbalance, and inflammaging. These changes can lead to increased sleep fragmentation and...

Sjögren's disease, an autoimmune disorder characterized by the presence of circulating autoantibodies and lymphocytic infiltrates in salivary glands, predominantly affects women later in life. By leveraging genetically heterogeneous UM-HET3 mice, this study tested the hypothesis that female sex and aging interact to shape susceptibility to autoimmunity and salivary gland inflammation. Female and male UM-HET3 mice were evaluated across the adult lifespan for the development of glandular...

Geometric shapes on 40,000-year-old bone and ivory suggest early European Homo sapiens long possessed cognitive tools for language

Search through space telescope’s archival images reveals unusually dim galaxy

Two-billion-year-old rocks in China suggest mountain building from Earth’s first supercontinent led to a planetwide burst of erosion

CONCLUSIONS AND IMPLICATIONS: The high prevalence and cross-country differences highlight the complexity of multimorbidity among adults aged 50 years and older in Europe and Israel. The findings reinforce the influence of demographic, clinical, and lifestyle factors and emphasize the need for public policies promoting healthy aging and integrated health care.