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TAS2R38 taster variants-linked MGAM expression in Alzheimer's disease: a novel target for precision drug repurposing
INTRODUCTION: TAS2R38 is a taste receptor gene located on human chromosome 7 that influences sensitivity to bitter tastes and has been implicated in innate immunity, glucose level, and human longevity. However, its potential association with Alzheimer's Disease (AD) has not been explored. Identifying such a genetic connection could support developing new drugs or repurposing existing ones for AD treatment.
Diet, gut microbiome, and cognition in neurodegeneration: a review and methodological framework
The gut microbiome influences brain function through the gut-brain axis via synthesis of neurotransmitters, production of metabolites affecting epithelial barrier integrity and immune modulation and signaling through the vagus nerve. In humans, microbiome diversity reflects healthy aging and predicts survival, while dysbiosis is increasingly implicated in neurodegenerative conditions including Alzheimer's disease, Parkinson's disease, multiple sclerosis, and ALS. Fecal transplant studies in...
Age-related changes in static and dynamic postural balance performance
CONCLUSION: Age-related changes in balance control are task dependent. Older adults preserved static balance performance but demonstrated impaired reactive balance responses in dynamic tasks. Furthermore, static and dynamic balance rely on distinct control mechanisms, highlighting the need for separate assessments.
Daily briefing: Why stress causes eczema to flare up in mice
Elusive ‘nuclear clocks’ tick closer to reality — after decades in the making
Spontaneous aging-associated inflammation and genome instability in the immune system of turquoise killifish
Paul R. Ehrlich obituary: pioneering ecologist who caused controversy by predicting a ‘population bomb’
I paused my PhD for 11 years to help save Madagascar’s seas
Briefing Chat: Are scientists funny? The evidence is in — and it's no joke
Mighty mini-magnet is low in cost and light on energy use
Author Correction: A PP1–PP2A phosphatase relay controls mitotic progression
The mid-career reset: how to be strategic about your research direction
Lab-grown oesophagus restores pigs’ ability to swallow
‘Unaffordable’ visa price hike threatens Australia’s researcher pipeline
Chemical pollutants are rife across the world’s oceans
Hormone linked to morning sickness may help reduce alcohol intake
GDF15, which is thought to contribute to nausea during pregnancy, may keep our drinking in check, researchers propose
Floating wetlands boost water quality, slash greenhouse emissions
Fabricated platforms at an Australian wastewater lagoon soak up water pollution and methane
The stop signal stepping task: how action cancellation commands disrupt step initiation in young and healthy older adults
Action cancellation - the ability to rapidly cancel an initiated movement in response to unexpected events - has been extensively studied in the upper limb using the stop signal task (SST). During gait, action cancellation is critical to stop and modify steps to avoid unexpected hazards and prevent falls. By adapting the SST to step initiation, this study investigated how the anticipatory postural adjustment (APA) and foot-lift phases of forward stepping were influenced by action-cancellation...
Correction to: Clonal hematopoiesis of indeterminate potential (CHIP) in cerebromicrovascular aging: implications for vascular contributions to cognitive impairment and dementia (VCID)
No abstract
Elucidation of a potent pro-resolving mediator of inflammation resolution via human neutrophil-vascular endothelial cell interactions
The acute inflammatory response is a highly coordinated programmed sequence that enables neutrophils to transmigrate from venules into tissues. Ideally self-limited, the active resolution phase produces specialized molecules that stimulate resolution and prevent collateral tissue damage from excessive neutrophil infiltration. The superfamily of pro-resolving molecules is termed specialized pro-resolving mediators including the essential polyunsaturated fatty acid-derived lipoxins, resolvins,...