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Programmable cellular protein factories
Science, Volume 392, Issue 6795, Page 252-253, April 2026.
Shaping tissues with defects
Science, Volume 392, Issue 6795, Page 255-256, April 2026.
In Other Journals
Science, Volume 392, Issue 6795, Page 266-267, April 2026.
Talk therapy
Science, Volume 392, Issue 6795, Page 330-330, April 2026.
Mesothermic fishes face high fuel demands and overheating risk in warming oceans
Science, Volume 392, Issue 6795, Page 301-305, April 2026.
Super-nano domains enable strength-conductivity synergy in copper foils
Science, Volume 392, Issue 6795, Page 275-279, April 2026.
Structural basis for DNA processing and membrane translocation by ComEC in natural transformation
Science, Volume 392, Issue 6795, Page 311-316, April 2026.
Guidance of cellular nematic elastomers into shape-programmable living surfaces
Science, Volume 392, Issue 6795, Page 317-323, April 2026.
Late Miocene Colorado River arrival in the Bidahochi basin supports spillover origin of Grand Canyon
Science, Volume 392, Issue 6795, Page 289-295, April 2026.
Calcium-triggered apoplastic ROS bursts balance gravity and mechanical signals for soil navigation
Science, Volume 392, Issue 6795, Page 296-300, April 2026.
Determination of the Solar System contribution to the soft x-ray sky
Science, Volume 392, Issue 6795, Page 285-288, April 2026.
Our cosmos, ourselves
Science, Volume 392, Issue 6795, Page 261-261, April 2026.
The life and legacy of George Schaller
Science, Volume 392, Issue 6795, Page 262-262, April 2026.
Reimagining human-centric drug development with new approach methodologies
Science, Volume 392, Issue 6796, Page 371-378, April 2026.
Grand canyon’s origin resolved? Ancient lake's flood may have etched famed gorge
Mineral grains show Colorado River filled a basin at the canyon’s head millions of years ago
Scientists stunned by ‘fundamentally new way’ life produces DNA
Newly discovered bacterial defense system challenges genetic code’s central dogma
First complete genome loaded onto a quantum computer
Researchers encode the tiny hepatitis D virus in an early step toward “quantum genomics”
Ten thousand years ago, human evolution went into overdrive
Ancient DNA reveals “massive” genetic shifts tied to rise of farming, wheels, and metal tools
Electromagnetic field-inducible in vivo gene switch for remote spatiotemporal control of gene expression
Gaining precise control of gene expression is crucial in biomedical applications. However, spatiotemporal precision remains challenging. Here, we present a remotely controlled in vivo gene switch responsive to electromagnetic fields (EMFs) that enables precise spatiotemporal activation of target genes. We uncovered the EMF-inducible gene switch activation mechanism via a CRISPR-Cas9 screen, identifying cytochrome b5 type B (Cyb5b) as an essential mediator likely acting as an EMF sensor. The...
Single-nucleus brain transcriptomics reveals microglia dysfunction in multiple system atrophy
Multiple system atrophy (MSA) is a rare, age-related neurodegenerative disease that shares clinical and pathological features with Parkinson's disease (PD) but presents a more devastating disease course. To elucidate the distinct cellular pathophysiology, we performed single-nucleus RNA sequencing on postmortem striatal brain tissue from 7 MSA and 12 PD patients, and 10 non-neurological cases. Here, we show significant compositional differences in astroglia and microglia subtypes, while...