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The burden of silence
Science, Volume 390, Issue 6779, Page 1314-1314, December 2025.
Electrode strain dynamics in layered intercalation battery cathodes
Science, Volume 390, Issue 6779, Page 1272-1277, December 2025.
Xanthomonas coordinates type III–type II effector synergy by activating fruit-ripening pathway
Science, Volume 390, Issue 6779, Page 1292-1298, December 2025.
A cellular basis for heightened gut sensitivity in females
Science, Volume 390, Issue 6779, Page 1285-1291, December 2025.
A bacterial nutrition strategy for plant disease control
Science, Volume 390, Issue 6779, Page 1299-1304, December 2025.
Trifluoromethylation of alkyl electrophiles with 11C- or 18F-labeled fluoroform for PET applications
Science, Volume 390, Issue 6779, Page 1278-1284, December 2025.
All-optical synthesis chip for large-scale intelligent semantic vision generation
Science, Volume 390, Issue 6779, Page 1259-1265, December 2025.
Extending the temperature range of the Cmcm phase of SnSe for high thermoelectric performance
Science, Volume 390, Issue 6779, Page 1266-1271, December 2025.
Risks of per- and polyfluoroalkyl substance exposure through marine fish consumption
Science, Volume 390, Issue 6779, Page 1305-1309, December 2025.
State-independent ionic conductivity
Science, Volume 390, Issue 6779, Page 1254-1258, December 2025.
The internet’s deepest infrastructure
Science, Volume 390, Issue 6779, Page 1237-1237, December 2025.
Listening to the languages of nature
Science, Volume 390, Issue 6779, Page 1236-1236, December 2025.
Our favorite science news stories of 2025
A mix of Science’s most loved and most read items of the year
Why are women more likely to get irritable bowel syndrome? New study provides clues
Cells in the guts of female mice respond to estrogen by increasing pain signaling, researchers find
<cite>Science</cite>’s 2025 Breakthrough of the Year: The unstoppable rise of renewable energy
Clean energy infrastructure is being deployed with unmatched scale and speed—and China is leading the way
Chile’s new president could shake up nation’s science community
Right-wing politician José Antonio Kast has promised to slash government spending
New materials could supercharge computer memory chips
Ferroelectrics could bolster “flash” memory in AI data centers and autonomous robots
Network-based transcranial direct current stimulation may improve gait and cognitive function in older adults: a randomized controlled crossover study
CONCLUSION: In healthy older adults, a single session of tDCS designed to modulate DAN and DN excitability concurrently improved gait speed in both single and dual-task walking, as well as working memory. These preliminary findings suggest that gait and working memory may be modifiable through neuromodulation approaches involving DAN and DN. Further studies are warranted to explore the relationship between gait, working memory, and these two brain networks using neuroimaging means.
Corrigendum to "A review of the TGF-beta1 pathway in Alzheimer's disease and depression: Possible restoration potential of antidepressants" [Neuroscience 585 (2025) 429-440]
No abstract
Plasma growth-associated protein 43 correlates with synaptic loss in Alzheimer's disease
Synaptic loss is a hallmark of Alzheimer's disease (AD) but lacks robust blood-based biomarkers. We investigate growth-associated protein 43 (GAP-43), previously identified as a synaptic candidate in the cerebrospinal fluid (CSF). Postmortem proteomic profiling of brain-derived extracellular vesicles (n = 21) highlights GAP-43 as a central hub within synaptic protein networks co-depleted in AD and closely linked with proteins enriched in immune-, metabolic-, and synaptic-related modules. In two...