Aggregator

As populations age worldwide, pathological neurodegeneration with subsequent cognitive decline has emerged as a pressing public health challenge. As effective treatments remain limited once neurodegeneration has occurred, prevention and delay of decline onset are crucial. While physical exercise is associated with improved cognition, exercise-specific mechanisms remain unclear. We therefore examined the effects of 12 weeks explosive lower-body resistance training (RT) in community-dwelling older...

Cerebral small vessel disease is a major contributor to stroke and cognitive decline and is characterized by white matter hyperintensities (WMH) and microstructural alterations detectable via diffusion-weighted imaging parameters, including free water (FW) and fractional anisotropy (FA). Hispanic/Latino populations experience a high burden of vascular risk factors. However, the impact of these factors on white matter integrity across diverse heritage groups remains underexplored in this...

Science, Ahead of Print.

Science, Ahead of Print.

Science, Ahead of Print.

Twist on classic Brownian motion experiment could help test bounds of quantum theory and aid search for new particles

Four complex physics problems are now within AI’s reach, researchers say

Researchers have designed a new DNA-based treatment that targets PCSK9, a protein closely tied to high LDL cholesterol and atherosclerosis. Their most effective molecule reduced PCSK9 protein by 87% in human liver cells and lowered cholesterol by 47% in genetically modified mice after a single injection.

People who drank at least one sugar-sweetened beverage a day had roughly 2.45 times the risk of gastric cancer compared with those who rarely consumed them, according to a decades-long study of more than 112,000 U.S. adults. Artificially sweetened drinks showed no similar association, though researchers stress that the findings do not prove sugary beverages cause cancer.

Hallucinogens and other psychoactive substances influenced everything from architecture to political power

An experimental compound called AP503 significantly strengthened bones in mice by activating GPR133, a receptor that boosts bone formation while slowing bone loss. Because the same treatment has also been linked to stronger muscles, researchers see intriguing potential for combating age-related decline and osteoporosis.

Semaglutide, the drug found in Ozempic and Wegovy, was linked to nearly 40% fewer asthma attacks in a large real-world study. It was also associated with about 20% fewer COPD flare-ups. Researchers say GLP-1 drugs may offer respiratory benefits in addition to their effects on diabetes and obesity, but clinical trials are needed to confirm the findings.

The first arm bone fragment from these mysterious human relatives was found near cutting instruments and animal remains in southwestern China

Cardiovascular disease is rapidly rising across ASEAN due to urbanization, ageing, and widespread risk factors, worsening health inequalities and economic burden. A shift toward preventive, life-course cardiovascular care is needed, supported by technologies like AI-enabled assessment and a strong investment focus on preventative measures specific to ASEAN populations. Singapore’s Healthier SG initiatives, including institution-based platforms like CRANE, demonstrate how preventive investment...