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Aging as the wound that fails to heal: a bioenergetic continuum of resolution failure

2 weeks 2 days ago
Aging may be conceptualized as a wound that fails to heal, characterized by persistent, unresolved inflammation. Building on Ogrodnik's "unhealed wound" model, this Perspective extends the Exposure-Related Malnutrition (ERM) framework to propose a bioenergetic interpretation of aging. ERM links chronic stress adaptation, nutrient misallocation, and mitochondrial insufficiency to sustained bioenergetic debt that impedes the transition from catabolic containment to anabolic repair. Across tissues,...
Torsak Tippairote

Potential dietary geroprotectors and their impact on key mechanisms of aging

2 weeks 2 days ago
Aging involves progressive accumulation of molecular and cellular damage, leading to functional decline and increased susceptibility to age-related diseases. Natural low-molecular-weight geroprotectors are substances of plant and food origin capable of modulating key mechanisms of aging. Based on current scientific data, sixteen fundamental mechanisms of aging are analyzed, and compounds from food that demonstrate potential in slowing age-related changes are presented. Special attention is paid...
Alexey Moskalev

An archaeal genetic code with all TAG codons as pyrrolysine

2 weeks 2 days ago
Science, Volume 390, Issue 6775, November 2025.
Veronika Kivenson, Samantha L. Peters, Guillaume Borrel, Aleksandr Kivenson, Leah T. Roe, Noah X. Hamlish, Khaled Fadhlaoui, Alanna Schepartz, Simonetta Gribaldo, Robert L. Hettich, Jillian F. Banfield