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Association between subjective well-being and low muscle mass among Chinese older adults: a nationwide cross-sectional study
CONCLUSION: Our findings suggest that subjective well-being is a nonlinear modifiable determinant of low muscle mass in older adults. These results indicate that interventions aimed at enhancing subjective well-being may complement conventional strategies for regulating muscle homeostasis.
Prevalence and factors associated with physical inactivity among older persons in Malaysia: Findings from the National Health and Morbidity Survey 2023
CONCLUSION: This study highlights a substantial prevalence of physical inactivity among older persons in Malaysia. Key factors significantly associated with physical inactivity include the presence of chronic conditions such as diabetes mellitus, functional limitations, self-care difficulties, overall disability, and sedentary behavior of more than 4 h. These findings underscore the need for targeted interventions and policies that address health conditions and functional impairments to promote...
Improving the care pathway for people living with HIV aged 70 years and older: the impact of geriatric screening in an infectious diseases unit (AUTO-HIV 70)
CONCLUSIONS: This study demonstrates the feasibility of organising geriatric screening in an infectious diseases unit. The proportion of changes that were implemented highlights the relevance of using these screening tests. It is, however, important to improve some of the screening tests used and raise awareness amongst people living with HIV and their doctors.
Mediating role of psychological resilience in the relationship between leisure-time activities and long-term mortality in older adults
CONCLUSIONS: Psychological resilience mediated the association between LTAs and all-cause mortality. Frequent participation in leisure activities may play a beneficial role in preventing premature death by improving resilience levels in community-dwelling older people.
The effect of Roy Adaptation Model on the quality of life and general health of elderly people in nursing homes: randomized controlled trial
CONCLUSION: The Roy Adaptation Model-based educational programs seem to be a successful strategy for raising the standard of living and fostering general health among senior citizens living in assisted living facilities.
Long-Term Dietary Restriction Has a Strong and Positive Effect on Both Hepatic and Peripheral Insulin Sensitivity, in an Age- and Diet-Dependent Manner
Dietary restriction (DR) improves insulin sensitivity, however, it has not been tested in long-term interventions and with diet type as variable. Therefore, we exposed mice to either a low-fat (LF) or high-fat-sucrose (HFS) diet, either fed ad libitum (AL) or in a DR regimen from weaning till 2 years of age. Using an oral glucose tolerance test with [6,6-²H(2)]-labelled glucose, we found that DR markedly reduced plasma insulin concentrations and strongly elevated hepatic and peripheral insulin...
PCBP2 Regulates p16(INK4a)-Dependent Cellular Senescence in Response to Iron
Recently, we have identified rs1333046 as one of the candidate functional single nucleotide polymorphisms (fSNPs) on the atherosclerosis-associated CDKN2A/B locus. However, how rs1333046 influences the pathogenesis of and susceptibility to atherosclerosis is unknown. In this work, we demonstrate that rs1333046 is part of a cis-regulatory element (cis-RE) that regulates p16^(INK4a) and p16^(INK4a)-dependent cellular senescence in human endothelial cells (ECs). This is achieved by recruiting...
Contextualizing Age-Friendly Care Within Social Drivers of Health
Social drivers of health (SDOH) impact health outcomes across the lifespan, with distinct effects on the health and well-being of older adults. SDOH contribute to outcomes of particular importance to older adults, including physical and cognitive functioning and aging in place, highlighting the critical importance of addressing SDOH as part of comprehensive, patient-centered geriatrics care. Yet, there is limited guidance on best practices for the integration of SDOH into healthcare,...
miRNA changes with ageing and caloric restriction in male rat skeletal muscle: potential roles in muscle cell function
The mechanisms underlying skeletal muscle ageing, whilst poorly understood, are thought to involve dysregulated micro (mi)RNA expression. Using young and aged rat skeletal muscle tissue, we applied high-throughput RNA sequencing to comprehensively study alterations in miRNA expression occurring with age, as well as the impact of caloric restriction (CR) on these changes. Furthermore, the function of the proteins targeted by these age- and CR-associated miRNAs was ascertained. Numerous known and...
Longitudinal changes in epigenetic measures over 2 years: methodological implications
Epigenetic clocks are increasingly proposed as surrogate endpoints in aging trials, yet their short-term behavior in healthy older adults is not well characterized. We analyzed DNA methylation at baseline, year 1, and year 2 in 899 COSMOS-Blood participants (mean age 70.0; 50% women), deriving Horvath, Hannum, PhenoAge, and GrimAge clocks (original and principal component [PC] versions) and DunedinPACE. Epigenetic age acceleration was computed by regressing each clock on chronological age....