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Placental nicotinamide adenine dinucleotide modulates the timing of labor

2 weeks 2 days ago
Labor is mediated proximately by prostaglandin signaling within gestational tissues and must be tightly regulated for birth to occur after appropriate fetal development. Metabolic changes accompanying gestational aging have been postulated as a determinant of birth timing, but specific nutrients, sensors, and messengers remain obscure. We report that placental nicotinamide adenine dinucleotide (NAD^(+)) dynamically tunes gestational length. Depletion of placental NAD^(+) in mice provoked labor...
Erin J Ciampa

Beyond technical access in digital eldercare: how ethical lag shapes stratified responsiveness to institutional welfare in rural China

2 weeks 2 days ago
CONCLUSIONS: The findings suggest that limited uptake of digital elder care is closely tied to moral legitimacy and ethical recognition. Digital care services are more likely to be accepted when perceived as a supportive extension of, rather than a replacement for, family care responsibilities. Addressing ethical lag through culturally resonant service design and trusted community mediation may help reduce inequalities in engagement and improve the effectiveness of ageing-related service...
Yuhe Liu