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Superconducting cables connect quantum bits on different chips, but improvements are still needed

Study adds to mounting evidence that traumatic experiences can negatively impact health years—or even decades—later

As AI firms churn out math breakthroughs, researchers question use of Lean software as proof checker

Why do some people stay mentally sharp even when their brains show signs of Alzheimer’s disease? Scientists in the Netherlands may have uncovered an important clue hidden in a rare group of immature brain cells. Researchers discovered that these cells remain present even in people over 80, but their behavior differs dramatically between those who develop dementia and those who remain cognitively healthy.

Mayo Clinic scientists have uncovered surprising new insights into “zombie cells,” aging cells that linger in the body and contribute to inflammation and disease. Seven studies reveal why these cells are harmful and identify new strategies for targeting them, including a natural compound found in tomatoes. In aging mice, experimental treatments reduced inflammation and improved physical and brain health. The findings could open the door to therapies that combat some of the biological processes behind aging.

A surprisingly simple exercise routine could help lower blood pressure without requiring daily workouts or expensive equipment. In a study of 100 adults, researchers found that wall squats performed just once or twice a week helped maintain significant reductions in systolic blood pressure over the short term.

Scientists have identified a hidden cause of inflammatory bowel disease: antibodies that disable the immune system’s natural ability to control inflammation, potentially explaining severe illness in thousands of patients. The breakthrough also solves a 30-year genetic mystery and could pave the way for more precise diagnoses and targeted treatments.

Regular exercise does more than strengthen the heart. New research reveals that it actually reshapes the nerves controlling how the heart functions, and the changes are surprisingly different on the left and right sides of the body.

Aging, neuroinflammation and metabolic dysfunction are tightly intertwined in Alzheimer's disease (AD), but how transient pathological signals become persistent cellular states remains poorly understood. Histone post-translational modifications (PTMs) provide a dynamic interface between extracellular stimuli, cellular metabolism and chromatin state. This Review examines how canonical histone modifications and emerging metabolite-derived acylations regulate inflammatory and stress-responsive...

Aging, neuroinflammation and metabolic dysfunction are tightly intertwined in Alzheimer's disease (AD), but how transient pathological signals become persistent cellular states remains poorly understood. Histone post-translational modifications (PTMs) provide a dynamic interface between extracellular stimuli, cellular metabolism and chromatin state. This Review examines how canonical histone modifications and emerging metabolite-derived acylations regulate inflammatory and stress-responsive...

High-quality reference genomes are essential for comparative and functional genomics yet remain unavailable for many emerging model organisms. Here, we report OctDeg2.0, a chromosome-level genome assembly and annotation of the degu (Octodon degus), generated using PacBio HiFi long-read sequencing and Hi-C scaffolding from a single male individual. Octodon degus is of growing interest as a natural animal model for aging and Alzheimer's disease research. The 3.4 billion base-pair assembly...

Resting-state electroencephalography is increasingly proposed as a scalable marker of healthy brain ageing, yet its interpretability depends on distinguishing stable individual characteristics from condition-dependent measurement effects. This secondary analysis of an open lifespan dataset examined periodic alpha activity, alpha-peak detectability, aperiodic spectral structure, short-term repeatability, and longitudinal change under eyes-open and eyes-closed conditions before and after an...

High-quality reference genomes are essential for comparative and functional genomics yet remain unavailable for many emerging model organisms. Here, we report OctDeg2.0, a chromosome-level genome assembly and annotation of the degu (Octodon degus), generated using PacBio HiFi long-read sequencing and Hi-C scaffolding from a single male individual. Octodon degus is of growing interest as a natural animal model for aging and Alzheimer's disease research. The 3.4 billion base-pair assembly...

Adipose tissue aging is increasingly recognized as a systemic process involving altered fat distribution, ectopic lipid deposition, and metabolic dysfunction, yet its shared genetic architecture remains incompletely characterized. In this study, we constructed a latent multivariate genetic phenotype of adipose tissue aging by integrating genome-wide association summary statistics for seven adipose- and metabolism-related traits, including visceral adipose tissue volume, abdominal subcutaneous...

DNA repair defects such as nucleotide excision repair (NER) mutations can lead to progeroid syndromes characterized by growth retardation and accelerated aging with distinct tissue type specific pathologies. DNA-damage-induced dysfunction of specific cell types can impair the organism's overall function. It is unknown whether, in reverse, DNA repair in specific tissues can have non-cell-autonomous consequences on other tissues carrying DNA damage. To explore the organismal consequences of...

In young animals, oligodendrocyte progenitor cells (OPCs) in the CNS efficiently differentiate into myelinating oligodendrocytes (OLs), whereas ageing reduces this capacity, impairing remyelination following demyelinating injury and adaptive myelination involved in learning. To identify factors that restore resilience in aged OPCs, we developed gSWITCH (https://altoslabs.shinyapps.io/gSWITCH/, https://github.com/Tanay-math/gSWITCH), a computational pipeline that captures dynamic gene-expression...

CONCLUSIONS: Among older adults in Shenzhen, the burden of stroke with comorbid hypertension and diabetes showed a long-term upward trajectory over the study period. Model-based projections suggested that the burden may increase from 2024 to 2033, particularly among males and older age groups. These findings provide population-level descriptive and projection evidence that may inform risk stratification and health service planning for ageing urban populations.

CONCLUSION: Life satisfaction in later life is associated with a multidimensional interplay of structural resources, health status, and existential orientation. Socioeconomic security and religious belief emerged as significant predictors of well-being, after controlling for health status. These findings highlight the importance of integrated policies addressing both material and psychosocial predictors of aging well.

CONCLUSIONS: Uptake and sustained engagement with SP via AAC referral appeared to be shaped less by individual capability than by physical opportunity, social opportunity and motivation. Primary care providers are well placed to facilitate engagement by leveraging trusted patient relationships, while centre managers and policymakers should address structural barriers such as zoning restrictions, language mismatch and age-identity mismatch. These findings offer actionable insights to optimise the...