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Similarities and differences in the self-assembly of actin filaments from different species inform our understanding of its evolution. However, this basic knowledge is largely incomplete. Here, we systematically characterize assembly kinetics for actin from two yeast species that are five hundred million years apart in evolution, Saccharomyces cerevisiae and Schizosaccharomyces pombe, and compare them to the well-studied rabbit muscle actin from which they diverged a billion years ago. We find...

CONCLUSION: Awareness of age-related losses may be adaptive when it reflects realistic recognition of age-related challenges, like hearing difficulties. Promoting positive, gain-focused views of aging could support earlier informal help-seeking among older adults by encouraging open conversations about hearing concerns within their close social networks.

Cancer and cell-aging studies may have relied on antibodies to incorrect molecule.

Labor is mediated proximately by prostaglandin signaling within gestational tissues and must be tightly regulated for birth to occur after appropriate fetal development. Metabolic changes accompanying gestational aging have been postulated as a determinant of birth timing, but specific nutrients, sensors, and messengers remain obscure. We report that placental nicotinamide adenine dinucleotide (NAD^(+)) dynamically tunes gestational length. Depletion of placental NAD^(+) in mice provoked labor...

CONCLUSIONS: The findings suggest that limited uptake of digital elder care is closely tied to moral legitimacy and ethical recognition. Digital care services are more likely to be accepted when perceived as a supportive extension of, rather than a replacement for, family care responsibilities. Addressing ethical lag through culturally resonant service design and trusted community mediation may help reduce inequalities in engagement and improve the effectiveness of ageing-related service...

After clearing a spring forecasting hurdle, scientists see growing odds of a powerful climate event that could disrupt weather worldwide

Researchers discovered that declining levels of phosphatidylcholine may be a major cause of age-related mitochondrial dysfunction and loss of cellular energy. Remarkably, boosting this nutrient restored more youthful mitochondrial performance in aging organisms, suggesting some aspects of aging can be slowed or reversed.

Science, Ahead of Print.

Science, Ahead of Print.

The government has tasked a group of scientists with assessing new technologies for “sustainable” oil and gas drilling—but many experts say it’s a fantasy

Understanding how the first patient became infected may shed new light on Andes virus’ transmission patterns and incubation period