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Science, Volume 390, Issue 6771, Page 400-404, October 2025.

Science, Volume 390, Issue 6771, Page 367-370, October 2025.

Science, Volume 390, Issue 6771, Page 377-380, October 2025.

Science, Volume 390, Issue 6771, Page 381-385, October 2025.

Science, Volume 390, Issue 6771, Page 386-389, October 2025.

Science, Volume 390, Issue 6771, Page 341-341, October 2025.

Science, Volume 390, Issue 6771, Page 342-342, October 2025.

Organizers aim to tune AI to help accelerate science

After a brutal heat wave, scientists race to predict how Bering Sea snow crabs will cope with climate change

School officials defend software as bulwark against ransomware, but professors fear potential surveillance of their devices

Millennia before the first cities, early Mesopotamians probably harnessed tides to irrigate crops

Early detection and late-stage cell fate assessment are key factors to develop therapeutic strategies, although current methods cannot capture early responses or distinguish multiple injury states, especially in ultraviolet-visible (UV-vis)-sensitive cells. Here, we introduce a method to simultaneously detect variations in RNA and DNA under near-infrared photoexcitation. Using a pyrazinacene-based probe (TEG(8)-N14), we unexpectedly achieved discrimination of multiple cell states, including...

No abstract

We establish a click reaction-based workflow (tissue clearing coupled with click-chemistry in 3D, C⁴-3D) to visualize 5-ethynyl-2'-deoxyuridine (EdU) in whole mouse brain tissue cleared by CUBIC, iDisco+, and PACT. C⁴-3D was compatible with immunostaining, nuclear staining, and a fluorescent reporter mouse. Machine learning-based identification of EdU-positive nuclear coordinates followed by normalization for the Allen Brain Atlas revealed that proliferating neuronal progenitors were enriched in...

Extracellular matrix homeostasis is crucial for hyaline cartilage integrity, however, the mechanism of extracellular matrix homeostasis in hyaline cartilage is poorly understood. Single-cell sequencing shows that VGLL4 is highly expressed in chondrocytes but declines after injury/aging. VGLL4 deficiency impairs collagen/elastin formation, causes extracellular matrix disorganization and osteoarthritis in Col2-CreERT2; Vgll4^(fl/fl) mice, and is exacerbated by destabilization of the medial...

Tissue structure and molecular circuitry in the colon can be profoundly impacted by systemic age-related effects but many of the underlying molecular cues remain unclear. Here, we build a cellular and spatial atlas of the colon across three anatomical regions and 11 age groups, encompassing ~1,500 mouse gut tissues profiled by spatial transcriptomics and ~400,000 single nucleus RNA-sequencing profiles. We develop a computational framework, cSplotch, which learns a hierarchical Bayesian model of...

No abstract

Relative fat mass (RFM) is a more accurate measure of body fat percentage than body mass index (BMI). However, its association with cardiometabolic multimorbidity (CMM) and its predictive value have not been examined. This study evaluated and compared the associations and predictive utility of RFM and BMI for CMM. We analyzed data from 3,348 adults (mean age 64 years; 45.1% male) in the English Longitudinal Study of Ageing who were free of hypertension, coronary heart disease, diabetes, and...

Torque Teno Virus (TTV) is a widespread commensal virus within the human virome, characterized by a high prevalence in human population and an unclear pathogenic role. Over the past three decades, TTV has garnered increasing attention due to its ability to establish lifelong chronic viremia, which intriguingly fluctuates among individuals in relation to immune competence status, with a typical peak after an organ transplantation, followed by a plateau and a slow decrease. The regulatory...

CONCLUSION: The prevalence of depressive symptoms among older women in institutional care in south-western Poland is moderate. The intensity of these depressive symptoms lowers the overall quality of life of care centre residents, as well as their self-assessment of health, and affects their quality of life in the psychological, social, and environmental domains.