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Internalized SNCA/α-synuclein fibrils become truncated and resist degradation in neurons while glial cells rapidly degrade SNCA fibrils

1 week 2 days ago
Parkinson disease (PD) and other α-synucleinopathies are characterized by the intracellular aggregates of SNCA/α-synuclein (synuclein, alpha) thought to spread via cell-to-cell transmission. To understand the contributions of various brain cells to the spreading of SNCA pathology, we examined the metabolism of SNCA aggregates in neuronal and glial cells. In neurons, while the full-length SNCA rapidly disappeared following SNCA pre-formed-fibril (PFF) uptake, truncated SNCA accumulated with a...
Md Razaul Karim

Calcifying plankton: From biomineralization to global change

1 week 2 days ago
Science, Volume 390, Issue 6771, October 2025.
Patrizia Ziveri, Gerald Langer, Sonia Chaabane, Joost de Vries, William Robert Gray, Nina Keul, Ian A. Hatton, Clara Manno, Richard Norris, Sven Pallacks, Jeremy R. Young, Ralf Schiebel, Stergios Zarkogiannis, Griselda Anglada-Ortiz, Stefania Bianco,…

Escherichia coli with a 57-codon genetic code

1 week 2 days ago
Science, Volume 390, Issue 6771, October 2025.
Wesley E. Robertson, Fabian B. H. Rehm, Martin Spinck, Raffael L. Schumann, Rongzhen Tian, Wei Liu, Yangqi Gu, Askar A. Kleefeldt, Cicely F. Day, Kim C. Liu, Yonka Christova, Jérôme F. Zürcher, Franz L. Böge, Jakob Birnbaum, Linda van Bijsterveldt, Jason…

Ancient origin of an urban underground mosquito

1 week 2 days ago
Science, Volume 390, Issue 6771, October 2025.
Yuki Haba, PipPop Consortium‡, Petra Korlević, Erica McAlister, Mara K. N. Lawniczak, Molly Schumer, Noah H. Rose, Carolyn S. McBrideMatthew L. Aardema, Maria O. Afonso, Natasha M. Agramonte, John Albright, Ana Margarida Alho, Antonio P. G. Almeida,…

In Science Journals

1 week 2 days ago
Science, Volume 390, Issue 6771, Page 347-349, October 2025.
Michael Funk, and Caroline Ash, Ian S. Osborne, Bianca Lopez, Jelena Stajic, Mark Aldenderfer, Courtney Malo, Jesse Smith, L. Bryan Ray, Di Jiang, Michael A. Funk, Phil Szuromi, Corinne Simonti, Sacha Vignieri, Madeleine Seale, Leslie Ferrarelli, Yury…

New frontiers in research on industrial decarbonization

1 week 2 days ago
Science, Volume 390, Issue 6771, Page 338-340, October 2025.
Kenneth T. Gillingham, Lint Barrage, Sarah Armitage, Dallas Burtraw, Jonathan Colmer, Laure de Preux, Jonathan Hawkins-Pierot, Charles Holt, Valerie J. Karplus, Åsa Löfgren, Ralf Martin, Nathan Miller, Mirabelle Muûls, Matthew Osborne, Edson Severnini,…