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Full freedom-of-motion actuators as advanced haptic interfaces
Science, Volume 387, Issue 6741, Page 1383-1390, March 2025.
A high-temperature nanostructured Cu-Ta-Li alloy with complexion-stabilized precipitates
Science, Volume 387, Issue 6741, Page 1413-1417, March 2025.
Abrupt sea level rise and Earth’s gradual pole shift reveal permanent hydrological regime changes in the 21st century
Science, Volume 387, Issue 6741, Page 1408-1413, March 2025.
A wheat tandem kinase and NLR pair confers resistance to multiple fungal pathogens
Science, Volume 387, Issue 6741, Page 1418-1424, March 2025.
High-frequency location data show that race affects citations and fines for speeding
Science, Volume 387, Issue 6741, Page 1397-1401, March 2025.
A geographic history of human genetic ancestry
Science, Volume 387, Issue 6741, Page 1391-1397, March 2025.
An end to human exceptionalism
Science, Volume 387, Issue 6741, Page 1360-1360, March 2025.
The meaning of our meals
Science, Volume 387, Issue 6741, Page 1359-1359, March 2025.
Genetic surprise gives horses exceptional endurance
A mutation that should have cut a protein short instead makes it more sensitive to the stress of exercise
News at a glance: Collider’s last run, early galaxy’s oxygen, and climate authors sought
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Activity-dependent regulation of Cdc42 by Ephexin5 drives synapse growth and stabilization
Synaptic Rho guanosine triphosphatase (GTPase) guanine nucleotide exchange factors (RhoGEFs) play vital roles in regulating the activity-dependent neuronal plasticity that is critical for learning. Ephexin5, a RhoGEF implicated in the etiology of Alzheimer's disease and Angelman syndrome, was originally reported in neurons as a RhoA-specific GEF that negatively regulates spine synapse density. Here, we show that Ephexin5 activates both RhoA and Cdc42 in the brain. Furthermore, using live imaging...
Age and gender differences in health characteristics of older people with visual impairment
CONCLUSION: The prevalence of VI is high older (> 55 years) adults in Cameroon, with clear differences between men and women. The oldest individuals, and women appear to be most vulnerable. The identification of at-risk groups/persons through this cross-sectional study should make it possible to adapt public health strategies to contribute to the WHO objective of healthy ageing.
Paying attention to proprioception: age affects ankle proprioception and the attentional demand of proprioceptive processing in sedentary adults
Ankle proprioception and attentional resources are crucial for maintaining balance and safely driving. However, research exploring the age-related integrity of ankle proprioception has yielded conflicting results, while the attentional demand of proprioceptive processing in seniors remains underexplored. We investigated how aging affects the interaction between proprioception and attention in healthy sedentary adults using a novel dual-task paradigm. Sedentary old and young adults performed an...
NAT10 and <em>N</em><sup>4</sup>-acetylcytidine restrain R-loop levels and related inflammatory responses
N⁴-acetylcytidine (ac⁴C) is deposited on diverse RNAs by N-acetyltransferase 10 (NAT10), a protein with high biological relevance for aging and cancer. We performed a comprehensive survey of ac⁴C using metabolic labeling, sodium cyanoborohydride chemical treatment coupled to next-generation sequencing (NGS), and ac⁴C antibody-based cell and molecular biology techniques. Our analysis shows that NAT10-dependent ac⁴C-acetylation is robust in rRNA and specific tRNAs but low/spurious in mRNA. It also...