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How a diagnosis altered my path
Science, Volume 389, Issue 6760, Page 658-658, August 2025.
Evolution of antiviral host defenses against a backdrop of endogenous retroelements
Science, Volume 389, Issue 6760, Page 588-593, August 2025.
Convergence and divergence of individual immune responses over the life course
Science, Volume 389, Issue 6760, Page 604-609, August 2025.
Sex differences in tissue-specific immunity and immunology
Science, Volume 389, Issue 6760, Page 599-603, August 2025.
Immune system influence on physiology
Science, Volume 389, Issue 6760, Page 594-599, August 2025.
The multifunctional immune system
Science, Volume 389, Issue 6760, Page 586-587, August 2025.
Strain-coupled, crystalline polymer-inorganic interfaces for efficient magnetoelectric sensing
Science, Volume 389, Issue 6760, Page 623-631, August 2025.
Three-dimensional nucleation and growth of deformation twins in magnesium
Science, Volume 389, Issue 6760, Page 632-636, August 2025.
Single-photon detection enabled by negative differential conductivity in moiré superlattices
Science, Volume 389, Issue 6760, Page 644-649, August 2025.
Imaging collective quantum fluctuations of the structure of a complex molecule
Science, Volume 389, Issue 6760, Page 650-654, August 2025.
Radular teeth matrix protein 1 directs iron oxide deposition in chiton teeth
Science, Volume 389, Issue 6760, Page 637-643, August 2025.
An orthogonal T7 replisome for continuous hypermutation and accelerated evolution in E. coli
Science, Volume 389, Issue 6760, Page 618-622, August 2025.
Revisiting the human sociobiology debate
Science, Volume 389, Issue 6760, Page 580-581, August 2025.
Roxie Laybourne, the first forensic ornithologist
Science, Volume 389, Issue 6760, Page 582-582, August 2025.
In Guinea, the United States helped beat back malaria. Now, the disease is set to soar
Foreign aid cuts are expected to cause a rise in malaria cases and deaths across sub-Saharan Africa
Canada plans a 15% budget cut. Scientists are alarmed
Cuts could erase promised boost, researchers fear
Could lithium stave off Alzheimer’s disease?
The metal is depleted in brains of people with disease and can reverse memory symptoms in mice, new study shows
Insulin signaling in microglia: A metabolic switch controlling neuroinflammation and amyloid pathology in Alzheimer's disease
Insulin resistance is a risk factor for Alzheimer's disease (AD). Chen et al.¹ show that microglial insulin signaling is essential for metabolic homeostasis and immune regulation, while insulin resistance impairs Aβ clearance and promotes neuroinflammation in AD. Their findings reframe AD pathogenesis through a cell-type-specific lens.
Lithium deficiency and the onset of Alzheimer's disease
The earliest molecular changes in Alzheimer's disease (AD) are poorly understood^(1-5). Here we show that endogenous lithium (Li) is dynamically regulated in the brain and contributes to cognitive preservation during ageing. Of the metals we analysed, Li was the only one that was significantly reduced in the brain in individuals with mild cognitive impairment (MCI), a precursor to AD. Li bioavailability was further reduced in AD by amyloid sequestration. We explored the role of endogenous Li in...
Cellular senescence in skeletal diseases: A bibliometric analysis from 2007 to 2024
CONCLUSION: Research in this field has garnered substantial attention in recent years. This bibliometric analysis not only underscores the correlation between cellular senescence and skeletal diseases, but also highlights that targeting cellular senescence and the SASP may offer potential therapeutic strategies. These findings can inform future research directions and the development of targeted interventions for age-related skeletal conditions.