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Telomere attrition becomes an instrument for clonal selection in aging hematopoiesis and leukemogenesis

2 months 3 weeks ago
The mechanisms through which mutations in splicing factor genes drive clonal hematopoiesis (CH) and myeloid malignancies, and their close association with advanced age, remain poorly understood. Here we show that telomere maintenance plays an important role in this phenomenon. First, by studying 454,098 UK Biobank participants, we find that, unlike most CH subtypes, splicing-factor-mutant CH is more common in those with shorter genetically predicted telomeres, as is CH with mutations in PPM1D...
Matthew A McLoughlin

Unlocking longevity through the comparative biology of aging

2 months 3 weeks ago
The comparative biology of aging leverages the remarkable diversity in aging rates and lifespans across species to uncover naturally evolved adaptations that promote longevity, disease resistance and injury resilience. The beauty of comparative biology is that it discovers adaptations that evolved outside of the protected laboratory environment, shaped by natural selection under real-world pressures. In this Review, we outline key approaches in comparative biology of aging studies, including the...
Cheyenne Rechsteiner

Early and long-term effects of maternal protein restriction on offspring organs and systems: insights from the developmental origins of health and disease (DOHaD)

2 months 3 weeks ago
Maternal malnutrition affects millions of people worldwide in two main ways: through food insecurity and hunger, as well as through diets high in ultra-processed, low-nutrient foods. These effects are often linked to deficiencies in specific macronutrients and micronutrients, which can lead to organ-specific consequences in the biological development of the child-a context explored within the framework of the Developmental Origins of Health and Disease (DOHaD). Given the extensive effects of...
Matheus Naia Fioretto

Assessment of surface EMG biomarkers in sarcopenic motor dysfunction during postural stabilization

2 months 3 weeks ago
CONCLUSION: This study identifies specific sEMG-derived features, particularly signal shape and complexity metrics, as potential non-invasive biomarkers for neuromuscular decline in sarcopenia. The Post-stab epoch emerges as a sensitive window for detecting deficits in motor control, supporting the use of perturbation-based tasks and sEMG analysis for early detection, monitoring, and intervention planning in aging populations.
I Junquera-Godoy

The National Dementia Workforce Study: Perspective From the National Institute on Aging

2 months 3 weeks ago
As the population of individuals living with Alzheimer's disease and related dementias (AD/ADRD) continues to grow, so does the need for a well-prepared and stable dementia care workforce. The National Dementia Workforce Study (NDWS) represents a significant investment to understand the demographics, experiences, and magnitude and scope of challenges faced by the professional and direct care workforce providing care to people with dementia. This article discusses the NDWS's goals, data...
Priscilla Novak

SCORE2-Older Persons (SCORE2-OP): Validation and Added Value of Excessive Daytime Sleepiness in a French Cohort

2 months 3 weeks ago
CONCLUSIONS: In this French cohort, SCORE2-OP overestimated cardiovascular risk and showed moderate discrimination. EDS improved SCORE2-OP performance in intermediate cardiovascular risk groups where treatments are uncertain, highlighting its clinical relevance; although implications for prevention strategies require further study.
Tahiana Andriambelosoa

Even at 100+: Acute Exercise Modulates Inflammatory Pathways in Centenarians

2 months 3 weeks ago
Centenarians exhibit remarkable disease resilience despite chronic low-grade inflammation. We investigated the inflammation-related proteome response to acute exercise in seven centenarians (100-104 years). Exercise downregulated 52 proteins (e.g., TNF, IL10, IL1RN, CCL family members) involved in immune cell trafficking, apoptosis, and cytokine regulation. Even at the extreme end of the lifespan, humans retain molecular responsiveness to exercise, with modulation of inflammation-related...
Abel Plaza-Florido

Impaired MAPT/tau-secretory lysosomes are linked to cognitive vulnerability in Alzheimer patients

2 months 3 weeks ago
MAPT/tau proteins propagate between brain regions in a prion-like manner, driving the onset and progression of dementia in Alzheimer disease (AD). However, the basis for variability in dementia progression among AD patients remains poorly understood. Here, we demonstrate that cognitively resilient AD patients, characterized by reduced MAPT/tau pathology, maintain lysosomal integrity, whereas cognitively vulnerable patients, exhibiting greater MAPT/tau burden, display lysosomal dysfunction....
Preeti Sharma

The house mouse maintains constant telomere length throughout life

2 months 3 weeks ago
Telomeres protect the chromosome ends from deleterious DNA damage response and repair activities. In humans, telomerase maintains telomere length in germ and stem cells, but not in most somatic cells. Consequently, telomeres shorten with cell division and age, limiting cell proliferation and protecting against cancer. When telomeres become critically short, they may also cause senescence, inflammation, and organ failure, which are major drivers of aging. Therefore, maintaining an optimal,...
Riham Smoom

Late-Life Aerobic Exercise Attenuates DNA Damage and Telomere Dysfunction in Non-Atheroprone but Not in Atheroprone Aortic Regions

2 months 3 weeks ago
Cellular senescence is a state of persistent cell cycle arrest and is a critical contributor to arterial aging. The primary drivers of cellular senescence are the DNA damage response (DDR) and telomere dysfunction, which is induced by increasing exposure to DNA-damaging stimuli such as atheroprone shear stress. While late-life aerobic exercise is an effective intervention to mitigate arterial aging, its specific impact on the DDR and telomere dysfunction is unknown and may not show uniform...
Jisok Lim

Septal LYVE1+ macrophages control adipocyte stem cell adipogenic potential

2 months 3 weeks ago
Science, Volume 389, Issue 6763, August 2025.
Xiaotong Yu, Yanan Hu, Hwee Ying Lim, Ziyi Li, Diego Adhemar Jaitin, Katharine Yang, Wan Ting Kong, Jiaqian Xu, David Alejandro Bejarano, Mathilde Bied, Lucie Orliaguet, Gowshika Rengasamy, Zachary Chow, Christopher Zhe Wei Lee, Josephine Lum, Jing Tian,…

Somatotopic organization of brainstem analgesic circuitry

2 months 3 weeks ago
Science, Volume 389, Issue 6763, August 2025.
Lewis S. Crawford, Fernando A. Tinoco Mendoza, Rebecca V. Robertson, Noemi Meylakh, Paul M. Macey, Kirsty Bannister, Tor D. Wager, Vaughan G. Macefield, Kevin A. Keay, Luke A. Henderson