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The new frontier in understanding human and mammalian brain development
Vector-stimuli-responsive magnetorheological fibrous materials
Assessing phylogenetic confidence at pandemic scales
Secretome translation shaped by lysosomes and lunapark-marked ER junctions
Targeting FSP1 triggers ferroptosis in lung cancer
Dispersion-engineered multipass optical parametric amplification
Meet the ‘Wee-rex’. Tiny tyrannosaur is its own species
Myriad Aryne Derivatives from Carboxylic Acids
A natural compound revitalizes the aging human immune system
Can AI be truly creative?
Chinese scientists increasingly lead joint projects with the UK, US and Europe
Antibody drugs show promise for treating bird flu and HIV
Researchers ‘decode’ Mandarin Chinese from neural signals
Advances in brain-computer interfaces could help millions who use tonal languages speak again after stroke or disease
Simple mix of enzymes shows how information arises out of chemical chaos
Roots of computational intelligence may lie deeper in matter than scientists thought
Canada’s new budget aims to lure U.S. researchers to relocate
Spending plan also calls for smaller research spending cut than feared
Australia’s red rocks hold mysteriously detailed fossils. We finally know how they formed
Chemical analysis could help predict locations of other ancient sites with impeccable fossils
Generation of human nucleus basalis organoids with functional nbM-cortical cholinergic projections in transplanted assembloids
The nucleus basalis of Meynert (nbM), the major cholinergic output of the basal forebrain, regulates cortical modulation, learning, and memory. Dysfunction of the nbM-cortical cholinergic pathway is implicated in neurodegenerative and neurodevelopmental disorders, including Alzheimer's disease (AD) and Down syndrome (DS). Here, we generated human nbM organoids (hnbMOs) from human pluripotent stem cells (hPSCs) containing functional cholinergic projection neurons. Then we reconstructed...
The Genetic Architecture of the Human Corpus Callosum and its Subregions
The corpus callosum (CC) is the largest set of white matter fibers connecting the two hemispheres of the brain. In humans, it is essential for coordinating sensorimotor responses and performing associative or executive functions. Identifying which genetic variants underpin CC morphometry can provide molecular insights into the CC's role in mediating cognitive processes. We developed and used an artificial intelligence based tool to extract the midsagittal CC's total and regional area and...
Senolytic-sensitive p16<sup>Ink4a</sup>+ fibroblasts in the tumor stroma rewire lung cancer metabolism and plasticity
Senescence has been demonstrated to either inhibit or promote tumorigenesis. Resolving this paradox requires spatial mapping and functional characterization of senescent cells in the native tumor niche. Here, we identify p16^(Ink4a)+ cancer-associated fibroblasts enriched with senescent phenotypes that promote fatty acid uptake and utilization by aggressive lung adenocarcinoma (LUAD) driven by Kras and p53 mutations. Furthermore, rewiring of lung cancer metabolism by p16^(Ink4a)+...
Dynamic metabolic and molecular changes during seasonal shrinking in <em>Sorex araneus</em>
To meet the challenge of wintering in place, many high-latitude small mammals reduce energy demands through hibernation. In contrast, short-lived Eurasian common shrews, Sorex araneus, remain active and shrink, including energy-intensive organs in winter, regrowing in spring in an evolved strategy called Dehnel's phenomenon. How this size change is linked to metabolic and regulatory changes to sustain their high metabolism is unknown. We analyzed metabolic, proteomic, and gene expression...