Aggregator
An ancient tree’s oddball shape is revealed by an extraordinary fossil
Daily briefing: Autoimmune disease linked to X chromosome
Crackdown on skin-colour bias by fingertip oxygen sensors is coming, hints FDA
Israel is flooding Gaza’s tunnel network: scientists assess the risks
Building used by Marie Curie will be dismantled to erect cancer centre
Elon Musk’s Neuralink brain chip: what scientists think of first human trial
‘Blue foods’ to tackle hidden hunger and improve nutrition
A forgotten Aztec scholar and more: Books in brief
The mystery of Feynman’s sprinkler is solved at last
Author Correction: Satellite mapping reveals extensive industrial activity at sea
Blood pressure pulsations modulate central neuronal activity via mechanosensitive ion channels
Science, Volume 383, Issue 6682, February 2024.
Whole-brain spatial organization of hippocampal single-neuron projectomes
Science, Volume 383, Issue 6682, February 2024.
Kinase-impaired BTK mutations are susceptible to clinical-stage BTK and IKZF1/3 degrader NX-2127
Science, Volume 383, Issue 6682, February 2024.
Hydrolytic endonucleolytic ribozyme (HYER) is programmable for sequence-specific DNA cleavage
Science, Volume 383, Issue 6682, February 2024.
Does fluoride in drinking water lower IQ? Question looms large in court battle
Experts clash over report suggesting fluoride can affect brain development
U.S. panel adds rare brain disease to newborn screening list, after push from families
Debate over whether to test babies for Krabbe disease reflects limited treatment options for fatal condition
Billion-dollar NASA mission will provide unprecedented view of ocean life
PACE satellite will capture subtle differences between plankton critical to their carbon-absorbing capacity
Transition of human γ-tubulin ring complex into a closed conformation during microtubule nucleation
Science, Volume 383, Issue 6685, Page 870-876, February 2024.
APOE loss-of-function variants: Compatible with longevity and associated with resistance to Alzheimer's disease pathology
The ε4 allele of apolipoprotein E (APOE) is the strongest genetic risk factor for sporadic Alzheimer's disease (AD). Knockdown of ε4 may provide a therapeutic strategy for AD, but the effect of APOE loss of function (LoF) on AD pathogenesis is unknown. We searched for APOE LoF variants in a large cohort of controls and patients with AD and identified seven heterozygote carriers of APOE LoF variants. Five carriers were controls (aged 71-90 years), one carrier was affected by progressive...
Identification of potential aggregation hotspots on Aβ42 fibrils blocked by the anti-amyloid chaperone-like BRICHOS domain
Protein misfolding can generate toxic intermediates, which underlies several devastating diseases, such as Alzheimer's disease (AD). The surface of AD-associated amyloid-β peptide (Aβ) fibrils has been suggested to act as a catalyzer for self-replication and generation of potentially toxic species. Specifically tailored molecular chaperones, such as the BRICHOS protein domain, were shown to bind to amyloid fibrils and break this autocatalytic cycle. Here, we identify a site on the Aβ42 fibril...