Aggregator
Policed and censored: professors in the southern US feel under siege
Komorebi
We need a new Turing test to assess AI’s real-world knowledge
How nanobots are accelerating cancer-targeting therapies
From MRI to Ozempic: breakthroughs that show why fundamental research must be protected
‘A real risk’: the rise of weapons that can act alone
Why we should limit the autonomy of AI-enabled weapons
World’s smallest 3D bioprinter could rebuild tissue during surgery
7 basic science discoveries that changed the world
Retraction Note: sFRP2 in the aged microenvironment drives melanoma metastasis and therapy resistance
Epigenetic dysregulation in aged muscle stem cells drives mesenchymal progenitor expansion via IL-6 and Spp1 signaling
Loss of MFE-2 impairs microglial lipid homeostasis and drives neuroinflammation in Alzheimer’s pathogenesis
Aging as a glitch in the matrix
Facing claims of animal abuse, a major breeder of research dogs will close its pipeline
Ridglan Farms has agreed to stop selling beagles for scientific studies, leaving just one major U.S. supplier
Vaccine protects people from paratyphoid fever in a ‘human challenge’ study
Volunteers who swallowed disease-causing bacteria were less likely to get sick after an oral vaccine
Aquarium hijinks provide strongest evidence yet that sharks love to play
Study hints at a deeper intelligence—and a need for enrichment in captivity
Meta and TikTok are obstructing researchers’ access to data, European Commission rules
Data are needed to study how social media spreads misinformation and influences elections, scientists say
To thwart food poisoning, tiny needles could inject bacteria-slaying viruses into your meal
Experimental patches on meat, fruits, and vegetables can destroy up to 99.9% of bacteria
3D-generation of high-purity midbrain dopaminergic progenitors and lineage-guided refinement of grafts supports Parkinson's disease cell therapy
The low in vivo yield of midbrain dopaminergic (mDA) neurons and uncertain lineage fates of donor cells following transplantation impede clinical application of human pluripotent stem cell (hPSC)-based cell therapy for Parkinson's disease (PD). We developed a three-dimensional (3D) differentiation method, SphereDiff, to generate high-purity mDA progenitors (mDAPs), leading to a significant enrichment of mDA neurons post transplantation. Grafted mDA neurons fully restored dopamine levels and...
Ribosome dysregulation and intervention in age-related infertility
Fertility in women decreases with age, but the molecular basis for age-related, unexplained infertility remains elusive. Here, we reveal distinct transcriptome changes in oocytes and surrounding cumulus cells from women in their mid-thirties, as evidenced by notably increased transcription of ribosome genes. Additionally, meiosis genes and actin and cohesin components are downregulated in oocytes with age. Lysosomes and proteostasis are also disrupted in cumulus cells. Moreover, DNA...