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Air taxis will soon be in our skies — if batteries can be made safer
Is this the future of food? 'Sexless' seeds that could transform farming
Veterinarians need to be part of West Nile disease storytelling
Include climate impacts when protecting infrastructure
Experiment puts ‘spoon bending’ to the test
China’s chikungunya virus outbreak is a wake up call
AI-agent ethics should consider sentient non-human animals
Vote by Dutch lawmakers threatens major primate research center
In victory for animal rights activists, research on monkeys would end in 2030
House Republicans add to support for maintaining NIH budget in 2026
Both chambers of Congress have now rejected Trump’s proposed 40% cut
Human ancestors braved England’s ice-covered northlands 440,000 years ago
How exactly ancient toolmakers survived the harsh conditions remains a mystery
Isotope-encoded spatial biology identifies plaque-age-dependent maturation and synaptic loss in an Alzheimer's disease mouse model
Understanding how amyloid beta (Aβ) plaques develop and lead to neurotoxicity in Alzheimer's disease remains a major challenge, particularly given the temporal delay and weak correlation between plaque deposition and cognitive decline. This study investigates how the evolving pathology of plaques affects the surrounding tissue, using a knock-in Aβ mouse model (App^(NL-F/NL-F)). We combined mass spectrometry imaging with stable isotope labeling to timestamp Aβ plaques from the moment of their...
Prioritising the primary prevention of heart failure
Heart failure remains one of the 21st century's greatest unmet clinical and public health challenges. Heart failure is a highly prevalent chronic condition that affects approximately 55 million people worldwide. Although heart failure can be prevented, the global burden of this condition continues to grow, fuelled by an ageing population, improved survival after myocardial infarction, and increasing prevalence of metabolic and kidney disease. Public health efforts for cardiovascular disease...
Isotope-encoded spatial biology identifies plaque-age-dependent maturation and synaptic loss in an Alzheimer's disease mouse model
Understanding how amyloid beta (Aβ) plaques develop and lead to neurotoxicity in Alzheimer's disease remains a major challenge, particularly given the temporal delay and weak correlation between plaque deposition and cognitive decline. This study investigates how the evolving pathology of plaques affects the surrounding tissue, using a knock-in Aβ mouse model (App^(NL-F/NL-F)). We combined mass spectrometry imaging with stable isotope labeling to timestamp Aβ plaques from the moment of their...
Global epidemiology and burden of osteoporosis among postmenopausal women: insights from the Global Burden of Disease Study 2021
Osteoporosis, primarily characterized by low bone mineral density (LBMD), is a major skeletal disorder among postmenopausal women (PMW), yet its global burden remains poorly quantified. Leveraging data from the Global Burden of Disease (GBD) Study 2021, we assessed the LBMD burden in PMW across 204 countries and territories between 1990 and 2021. Metrics included deaths, disability-adjusted life years (DALYs), years of life lost (YLLs), and years lived with disability (YLDs), with temporal...
REV-ERBα regulates brain NAD<sup>+</sup> levels and tauopathy via an NFIL3-CD38 axis
Nicotinamide adenine dinucleotide (NAD^(+)) is a critical metabolic co-enzyme implicated in brain aging, and augmenting NAD^(+) levels in the aging brain is an attractive therapeutic strategy for neurodegeneration. However, the molecular mechanisms of brain NAD^(+) regulation are incompletely understood. In cardiac tissue, the circadian nuclear receptor REV-ERBα has been shown to regulate NAD^(+) via control of the NAD^(+)-producing enzyme NAMPT. Here we show that REV-ERBα controls brain NAD^(+)...
How ageing changes our genes - huge epigenetic atlas gives clearest picture yet
No abstract
Failure of efficient cardiac proteostatic adaptations to chronic cAMP-stress is associated with accelerated heart aging
Dysregulated proteostasis is a hallmark of aging. We investigated how efficiently proteostatic adaptations to chronic cardiac cyclic-adenosine-monophosphate (cAMP)-dependent stress change with aging in mice harboring marked cardiac-specific over-expression of adenylyl cyclase VIII (TG^(AC8)). We assessed protein quality control mechanisms (PQC) (ubiquitin proteasome system, autophagic flux via macroautophagy, and mitophagy) in left ventricles of TG^(AC8) and wild-type littermates (WT) at 3-4 and...
Visual Scanning and Falls in Older Adults: The Mexico Health and Aging Study
CONCLUSIONS: People with lower levels of visual scanning behavior were more likely to suffer recurrent falls over time. This highlights the importance of visual function and behavior in mitigating fall risk and suggests that efforts to improve visual scanning may help to prevent recurrent falls in older adults.
Normal Ageing Impacts the Extent and Diversity of Neural Plasticity Induced in the Mouse Brain With Repetitive Transcranial Magnetic Stimulation
Repetitive transcranial magnetic stimulation (rTMS) is an attractive tool to promote healthy brain ageing in older adults and treat age-related neurological conditions. Despite its popularity, the neurological processes and plasticity mechanisms altered by rTMS in the aged brain, and where these changes occur in the brain are unknown. Furthermore, it is not known why different rTMS protocols induce different changes in the aged brain, or why rTMS is less effective in older adults compared to...
Age-Related Changes in the Clinical Picture of Long COVID
CONCLUSIONS: Within the limits of this observational study, we conclude that in community-dwelling older adults, aging alters the prevalence and pattern of reported Long COVID.