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Age-related neurodegenerative diseases involve reduced cell numbers and impaired behavioral capacity. Neurodegeneration and behavioral deficits also occur during aging, and notably in the absence of disease. The cerebellum, which modulates movement and cognition, is susceptible to cell loss in both aging and disease. Here, we demonstrate that cerebellar Purkinje cell loss in aged mice is not spatially random but rather occurs in a pattern of parasagittal stripes. We also find that aged mice...

The proprioceptive and visual systems play a major role in daily tasks by providing continuous feedback to the central nervous system (CNS) for coordinating movements. However, it remains unclear to what extent alterations in the proprioceptive system and CNS affect vibration-induced illusion of movement (VIM) with age and after a stroke. To address this, 29 young (26 ± 7 years), 30 older (63 ± 8 years), and 26 stroke participants (68 ± 12 years) with left arm impairment, all right-handed,...

Caloric (CR) or dietary (DR) restriction improves health and extends lifespan in multiple species. However, the beneficial effects of DR may diminish if introduced late in life, emphasizing the importance of timing for promoting healthspan and avoiding adverse outcomes. Using a metabolomics approach, we investigated the metabolic responses in plasma, liver, and kidney of mice on acute and chronic DR at various ages. Two hundred and five mice including young (2-month-old; n = 72), middle-aged...

X-ray observatory and mission to Saturn’s moon Enceladus win as ESA’s science program sees growth

Monoclonal antibodies approved for Alzheimer's disease (AD), such as lecanemab and aducanumab, have been shown to enhance microglial phagocytic function, underscoring the therapeutic relevance of microglia in neurodegenerative diseases (NDDs). Emerging evidence implicates lipid droplets (LDs) in brain aging and NDDs, particularly through LDs-laden microglia known as lipid droplet-accumulating microglia (LDAM), which exhibit impaired phagocytosis, elevated oxidative stress, and dysregulated lipid...

Immunological memory is a defining feature of immunity, and a quantitative description of how it wanes would help better understand the processes underlying its maintenance and estimate the duration of protection after immunization. We analyzed the waning of antibodies to a panel of virus and vaccine antigens and found that a power-law model captured both the initial rapid decline and much slower subsequent waning. Importantly, accounting for the time post-immunization at which the waning was...

The adoption of digital therapeutics among older adults presents both opportunities and challenges in modern healthcare. While these technologies enhance disease management, autonomy, and quality of life, engagement remains hindered by cognitive, emotional, systemic, and sociocultural barriers. This narrative review synthesizes findings from 76 peer-reviewed studies identified through Scopus and Web of Science (2010-2024) to examine key factors influencing geriatric engagement with digital...