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The interplay between circadian rhythms and aging: molecular mechanisms and therapeutic strategies
Circadian rhythms are essential biological systems operating on a 24-h cycle, playing a crucial role in regulating sleep, cognitive function, immune responses, and hormone secretion. This review explores the intricate relationship between circadian rhythms and aging, with a focus on the underlying molecular mechanisms. It discusses age-related changes in sleep patterns and the role of circadian disruption in the progression of neurodegenerative diseases such as Parkinson's and Alzheimer's....
JC Stand-by-U- development and evaluation of an in-home respite service model using mixed-method quasi-experimental design: study protocol
BACKGROUND: In an ageing society, most older adults who require long-term care are still living in their homes and communities. Their families are burdened by caregiving duties, but their unique needs are often overlooked. In response to the increasing needs of respite care, the Jockey Club Stand-by-U (JC Stand-by-U) Caregivers Community Support Project aims to study the family caregivers' needs and how to best support them in the context of Hong Kong.
Heterozygous variants in <em>PLCG1</em> affect hearing, vision, cardiac, and immune function
Phospholipase C isozymes (PLCs) hydrolyze phosphatidylinositol 4,5-bisphosphate (PIP(2)) into inositol 1,4,5-trisphosphate (IP(3)) and diacylglycerol (DAG), important signaling molecules involved in many cellular processes including Ca^(2+) release from the endoplasmic reticulum (ER). PLCG1 encodes the PLCγ1 isozyme that is broadly expressed. Hyperactive somatic mutations of PLCG1 are observed in multiple cancers, but only one germline variant has been reported. Here, we describe seven...
Alteration of long- and short-term hematopoietic stem cell ratio causes myeloid-biased hematopoiesis
Myeloid-biased hematopoiesis is a well-known age-related alteration. Several possibilities, including myeloid-biased hematopoietic stem cell (HSC) clones, may explain this. However, the precise mechanisms remain controversial. Utilizing the Hoxb5 reporter system to prospectively isolate long-term HSCs (LT-HSCs) and short-term HSCs (ST-HSCs), we found that young and aged LT-HSCs co-transplanted into the same recipients demonstrated nearly equivalent myeloid lineage output, contrary to the theory...
Zuogui and Yougui pills extend lifespan and improve ageing biomarkers via kaempferol-mediated mitophagy in Caenorhabditis elegans
Zuogui pill (ZGP) and Yougui pill (YGP) are classical kidney-tonifying formulas in Traditional Chinese Medicine, widely used clinically but with their potential to delay ageing and improve ageing biomarkers remaining unclear. This study combined network pharmacology and Caenorhabditis elegans models to investigate the anti-ageing effects and mechanisms of ZGP and YGP. Both formulas significantly extended lifespan (ZGP dose-dependently at 5-20 mg/mL; YGP at 20 mg/mL) and improved ageing...