Aggregator

CONCLUSIONS: Within the limits of this observational study, we conclude that in community-dwelling older adults, aging alters the prevalence and pattern of reported Long COVID.

Metabolomics has been associated with cognitive decline and dementia, but the relationship between metabolites and brain aging remains unclear. We aimed to investigate the associations of metabolomics with brain age assessed by neuroimaging and to explore whether these relationships vary according to apolipoprotein E (APOE) ε4. This study included 17,770 chronic brain disorder-free participants aged 40-69 years from UK Biobank who underwent neuroimaging scans an average of 9 years after...

The complexity of epigenetic changes that accompany aging has been distilled into a number of molecular timepieces-termed epigenetic clocks-that characterize the pace of biological aging to differing degrees. Here, we develop and validate a DNA methylation-based Physiological health Age (PhysAge) score, comprised of eight DNA methylation surrogates to represent multi-system physiology and developed from commonly measured clinical biomarkers: CRP, peak flow, pulse pressure, HDL-cholesterol,...

Kidney function declines progressively with age, with chronic kidney disease (CKD) affecting more than half of community-dwelling older adults. Identifying risk factors beyond the established ones (such as diabetes and hypertension) is crucial for prevention. Frailty and malnutrition are prevalent in older adults, yet the effect of these factors on their decline of kidney function remains underexplored. This study aimed to elucidate the associations between frailty, malnutrition, and renal...

CONCLUSION: Higher consumption of UPFs is positively associated with accelerated biological aging, with adiposity measures serving as significant mediators.

Inflamm-aging is widely considered a hallmark of aging, yet emerging evidence challenges its universality. Here, we re-examine inflamm-aging through an eco-evolutionary lens, underlining its context dependence across biological scales. Combining mechanistic, evolutionary, comparative, anthropological, genetic, and environmental evidence, we show how fundamental inflammatory mechanisms are integrated and regulated in diverse biological contexts, representing a suite of flexible stress responses....

This study examines how neighborhood social cohesion and physical disorder, measured at baseline and as change over time, are associated with multiple chronic conditions (MCCs) among older adults and whether these associations vary by race/ethnicity. Using 6 years of data from the National Health and Aging Trends Study (2015-2021), mixed-effects Poisson regression models were applied to a sample of 3,389 community-dwelling older adults. Higher social cohesion at baseline and increases in...

CONCLUSION: intergenerational support from adult children significantly enhances the intrinsic capacity of older adults by promoting social engagement and maintaining functional ability. To advance healthy and active aging, policy efforts should adopt a function-oriented approach that strengthens both family-based support systems and community care infrastructure, while fostering cross-generational resource sharing and coordinated support.

The "gut-brain axis" is an emerging target in Alzheimer's disease (AD), although its immunological features remain poorly understood. Using single-cell RNA sequencing, coupled to extensive spectral-tuning flow cytometry validation of the colon immune compartment in the 5XFAD amyloid-β mouse model, we found several AD-associated changes including in B/plasma cell activity. Notably, levels of CXCR4^(+) antibody-secreting cells are reduced in 5XFAD colons. This change corresponds with accumulating...

Alzheimer's disease (AD) is marked by neuroinflammation, neurodegeneration and cognitive decline, with emerging evidence highlighting the critical roles of cytokines and chemokines in its pathogenesis. Regulated cell death is a highly structured and meticulously coordinated series of molecular and signalling processes involving gene expression and protein activity. This mechanism is essential for normal developmental processes and the preservation of tissue homeostasis. Abnormal regulation of...