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Programmable antisense oligomers for phage functional genomics
The emergence of globular clusters and globular-cluster-like dwarfs
Human gastroids to model regional patterning in early stomach development
The oldest known lepidosaur and origins of lepidosaur feeding adaptations
Long-range PM<sub>2.5</sub> pollution and health impacts from the 2023 Canadian wildfires
Jelly-filled garment keeps wearers cool when heat and humidity soar
Feeling the heat: fossil-fuel producers linked to dozens of heatwaves
Editorial Expression of Concern: Recovery of learning and memory is associated with chromatin remodelling
Mitochondria-associated condensates maintain mitochondrial homeostasis and promote lifespan
Senescent-like border-associated macrophages regulate cognitive aging via migrasome-mediated induction of paracrine senescence in microglia
Plasma proteomic associations with Alzheimer’s disease endophenotypes
Population aging in Japan offers a warning and a template for action
Scientists take on Trump: these researchers are fighting back
Using biobanks to boost research: a how-to guide
The earth will not consume our bones
‘Incredible’ fossil reveals earliest relative of lizards and their kin
Paleontologists use x-rays to reconstruct ancient reptile bones too fragile to remove from rock
SIRT2 and NAD(+) Boosting Broadly Suppress Aging-Associated Inflammation
Aging leads to chronic inflammation that is linked to aging-associated conditions and diseases. Multiple immune pathways become activated during aging, posing a challenge to effectively reduce aging-associated inflammation. SIRT2, an NAD^(+)-dependent deacetylase, suppresses several immune pathways that become activated during aging and may represent an attractive target to broadly dampen aging-associated inflammation. Here, we show that SIRT2 deficiency leads to increased inflammation governed...
Fluphenazine, an antipsychotic compound, ameliorates Alzheimer's disease by clearing amyloid beta accumulation in C. elegans
The aging population worldwide faces an increasing burden of age-related conditions, with Alzheimer's disease being a prominent neurodegenerative concern. Drug repurposing, the practice of identifying new therapeutic applications for existing drugs, offers a promising avenue for accelerated intervention. In this study, we utilized the yeast Saccharomyces cerevisiae to screen a library of 1760 FDA-approved compounds, both with and without rapamycin, to assess potential synergistic effects on...
Mild cognitive impairment impacts association of functional brain connectivity with cognition in older adults with and without multiple sclerosis
Cognitive decline is common in multiple sclerosis (MS), although neural mechanisms are not fully understood. The objective was to investigate the impact of mild cognitive impairment (MCI) on the relationship between resting state functional connectivity (RSFC) and cognitive function in older adults with multiple sclerosis (OAMS) and age matched healthy controls. Participants underwent magnetic resonance imaging (MRI) scans and cognitive assessments. The Oral Symbol Digit Modalities Test (SDMT)...
Emerging strategies, applications and challenges of targeting NAD<sup>+</sup> in the clinic
Beyond their classical functions as redox cofactors, recent fundamental and clinical research has expanded our understanding of the diverse roles of nicotinamide adenine dinucleotide (NAD) and nicotinamide adenine dinucleotide phosphate (NADP) in signaling pathways, epigenetic regulation and energy homeostasis. Moreover, NAD and NADP influence numerous diseases as well as the processes of aging, and are emerging as targets for clinical intervention. Here, we summarize safety, bioavailability and...