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Variation in the Content of Three Tandem Repeats of the Human Genome (Ribosomal, Satellite III, and Telomere) in Peripheral Blood Leukocyte DNA of People of Different Ages (5-101 Years)
The variation of ribosomal (parameter R), satellite III (1q12) (parameter S), and telomere (parameter T) tandem repeats content of the human genome was studied in DNA samples isolated from blood leukocytes of 535 people whose age varied from 5 to 101 years. For analysis we used the method of nonradioactive quantitative hybridization. The group of centenarians (90-101 years old, N = 106) differs from other age groups by a significantly narrower distribution of the ribosomal repeat content in DNA,...
RETRACTION: TLR4 Modulates Senescence and Paracrine Action in Placental Mesenchymal Stem Cells via Inhibiting Hedgehog Signaling Pathway in Preeclampsia
[This retracts the article DOI: 10.1155/2022/7202837.].
Correction: Realistic expectations for changes to average human lifespan in the near future
No abstract
Dual-Lineage Chondrocyte-Like Cells in the Nucleus Pulposus of Aging Intervertebral Discs Are Accelerated by Hedgehog Signaling Inactivation
Intervertebral disc (IVD) degeneration, a major contributor to chronic low back pain, is characterized by the age-related replacement of notochord-derived nucleus pulposus cells (NPCs) with chondrocyte-like or fibrotic cells (CLCs). However, the cellular origins of CLCs and mechanisms driving their emergence remain contentious. Using genetic lineage tracing with Shh-Cre and Gli1-CreER^(T2) to track notochordal and non-notochordal cells, respectively, we demonstrate that CLCs arise from dual...
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DJ-1/PARK7 in Parkinson's disease: mechanisms of pathogenesis and therapeutic potential
Parkinson's disease (PD) is the second most prevalent neurodegenerative disorder, characterized by the substantial degeneration of nigral dopaminergic neurons, the accumulation of alpha-synuclein, and the intraneuronal formation of Lewy bodies. DJ-1 is a multifaceted protein that has been linked to the pathogenesis of neurodegenerative diseases. Recent research has highlighted a potential role for DJ-1 in PD. This protein plays a critical role in maintaining mitochondrial homeostasis, modulating...
Correlation of adult neurogenesis and cognitive performance in touchscreen tasks - assessing the novel small molecule OXS-N1 in mice
Adult hippocampal neurogenesis in the dentate gyrus is well-defined in rodents, and its role in cognitive functions as well as its potential as a therapeutic target for neurodegenerative diseases such as Alzheimer's disease remain a topic of great scientific interest. In this study, we evaluated the effects of a novel small molecule, OXS-N1, on neurogenesis and behavior in C57Bl/6 wild-type and 5xFAD Alzheimer's disease model mice, which were tested independently at different ages. Modern,...