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From wrist data to lifespan: elucidating inflammation-driven biological aging via activity rhythms captured by wearable devices

2 months 2 weeks ago
Systemic inflammation ("inflammaging") accelerates biological aging and drives cardiovascular, metabolic, and neurodegenerative disease. Circadian rhythms regulate the amplitude and timing of immune responses, yet their mechanistic role in inflammation and longevity remains unexplored. In 62,000 adults with 7-day wearable accelerometry, interpretable machine learning model identified rhythm amplitude, stability, and moderate-to-vigorous physical activity (MVPA) as dominant predictors of...
Jinjoo Shim

Reference values for gait speed, five-times-sit-to-stand test, balance, and handgrip strength: analysis of data from the English Longitudinal Study of Ageing

2 months 2 weeks ago
Simple performance-based tests such as gait speed, the Five-Times-Sit-to-Stand Test (FTSST), balance tests, and handgrip strength are associated with health outcomes. We aimed to establish age- and sex-specific reference (normative) values for these tests in the English population. Adults aged ≥ 50 years (female n = 4,234; male n = 3,424) from the English Longitudinal Study of Ageing were included. Weighted percentiles ranging from the 5th to the 95th percentile [P5-95] were calculated. Best...
Jozo Grgic

A cellular basis for the mammalian nocturnal-diurnal switch

2 months 2 weeks ago
Science, Volume 391, Issue 6788, February 2026.
Andrew D. Beale, Matthew J. Christmas, Nina M. Rzechorzek, Andrei Mihut, Aiwei Zeng, Christopher Ellis, Nathan R. James, Nicola J. Smyllie, Violetta Pilorz, Rose Richardson, Mads F. Bertelsen, Shaline V. Fazal, Zanna Voysey, Kevin Moreau, Jerry Pelletier…