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Aging research has primarily focused on adult aging clocks, leaving a critical gap in understanding a biological clock across the full life cycle, particularly during infancy and childhood. Here we introduce LifeClock, a biological clock model that predicts biological age across all life stages using routine electronic health records and laboratory test data. To enhance individualized predictions, we integrated virtual patient representations from 24,633,025 heterogeneous longitudinal clinical...

The 70-kDa heat shock protein (Hsp70) chaperone is essential to maintain cellular protein homeostasis, facilitating the folding, assembly, membrane translocation and quality control of proteins. Hsp70s achieve their functions through 'selective promiscuity', interacting with a wide range of substrate proteins while minimizing undesired interactions. J-domain proteins (JDPs) and nucleotide exchange factors (NEFs) are key to substrate recognition, remodelling and release from chaperone complexes....

Across the evolutionary spectrum, sexual interactions can significantly influence the physiology and somatic aging in various species. In Caenorhabditis, male pheromones, sperm, and seminal fluid shorten the lifespan of hermaphrodites through different mechanisms. However, the specific male seminal fluid proteins responsible for this effect remain unidentified. Here, we find that several of the previously observed physiological changes in mated hermaphrodites require a newly-identified seminal...

CONCLUSION: In this study, it was found that quality of life decreased with increasing kinesiophobia, whereas quality of life increased with increasing level of successful aging. Longitudinal studies on quality of life in the elderly are recommended.

CONCLUSION: Our results imply that for those born small, having lower educational level is associated with having worse physical function at late-life, partly through less physical activity throughout the life-course.

CONCLUSIONS: Government-procured pDXA enables cost-effective universal OP screening in resource-limited rural areas. Scaling this model requires culturally adapted education (e.g., Wu Chinese dialect audiovisual materials) and tiered medication subsidies for groups with low medical payment capacity, aligning with the UN Decade of Healthy Aging (United Nations, UN Decade of Healthy Aging 2021-2030, World Health Organization, 2020).

Teaching chatbots to say “I don’t know” could curb hallucinations. It could also break AI’s business model