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Age-related hearing loss (ARHL) has emerged as a significant and potentially modifiable risk factor for neurodegenerative disorders, including Alzheimer's disease. A growing body of evidence links ARHL to structural and functional changes in the brain, with implications for cognitive decline and dementia onset. However, both ARHL and dementia are multifactorial conditions shaped not only by biological mechanisms but also by broader social determinants of health. Inequities in access to hearing...

BACKGROUND: Systematic analyses of global health trends can provide an accurate narrative of progress and challenges. We analysed the impact of changing age-specific mortality (epidemiology) and age structure (demography) on crude death rates (CDRs) and causes of death with large or rising mortality to inform the third Lancet Commission on Investing in Health.

CONCLUSIONS: A stronger risk of total mortality was found when worse SWB and unhealthy lifestyle occurred together, suggesting that a comprehensive approach to healthy lifestyle and SWB might be a potential strategy to improve longevity.

Aging is closely related to the decline of male reproductive endocrine function, which is manifested as insufficient testosterone production. It is well known that stem cell pool stability is crucial for maintaining tissue function. However, the relationship between aging and the stem Leydig cell (SLC) pool homeostasis remains unclear. Here, we demonstrate that extracellular matrix (ECM) stiffness increases in aging testes, and SLC pool homeostasis is imbalanced. Mechanistically, high ECM...

The longitudinal directionality between depressive symptoms and biological aging acceleration has yet to be thoroughly investigated. This study included 5442 Chinese adults aged 45-80 years from the 2011 and 2015 survey waves of China Health and Retirement Longitudinal Study. Multiple biomarker-based biological age was estimated using the Klemera and Doubal method, and biologically older was defined as biological age larger than chronological age. Depressive symptoms were identified using a...

Neuropathic pain (NP) is a complex pain disorder that constitutes a significant problem in the aging population, impacting quality of life and everyday functioning. In the quest to develop effective treatments, much research effort has been made to understand brain activity in people with NP, revealing a number of disordered electroencephalogram (EEG) patterns. This information can then be used to inform neurofeedback therapy, a novel approach that involves volitionally training brain activity...

Lactate is the end product of anaerobic glycolysis. Its functions in the central nervous system have garnered increasing attention as new roles continue to emerge. Beyond serving as an energy source and a substrate for gluconeogenesis, lactate also functions as a signaling molecule that regulates diverse cellular activities. Recent studies have demonstrated that lactate contributes to protein lactylation-a novel posttranslational modification-and plays a crucial role in metabolic reprogramming....

Early detection of Alzheimer's disease remains complex and costly despite advancements in neurobiological markers. We propose an innovative approach based on the topological and kinetic analysis of verbal exchanges to distinguish patients from healthy individuals. Without requiring full transcription, we leverage a convolutional network capable of identifying discursive patterns indicative of cognitive impairments. Our experiments, conducted with 80 participants, demonstrate performance levels...

Cerebrospinal fluid (CSF) total tau (t-tau) is considered a biomarker of neuronal degeneration alongside brain atrophy and fluid neurofilament light chain protein (NfL) in biomarker models of Alzheimer's disease (AD). However, previous studies show that CSF t-tau correlates strongly with synaptic dysfunction/degeneration biomarkers like neurogranin (Ng) and synaptosomal-associated protein 25 (SNAP25). Here, we compare the association between CSF t-tau and synaptic degeneration and...

CONCLUSIONS: We believe that the results of our review indicate accelerated epigenetic ageing in people living with HIV compared to uninfected individuals. There is a need for further research, which will analyse material from different tissues and take into account a number of biomarkers and the mentioned confounding factors. Studies considering the impact of individual classes of antiretroviral drugs, the age of the patient at the time of HIV diagnosis, and the timeliness of diagnosis on...

Second-order conditioning (SOC) enables animals to form associations between stimuli without direct reinforcement. In this study, we present a behavioral analysis pipeline that combines a light-tone SOC paradigm in mice with tools such as DeepLabCut, Keypoint-MoSeq, and DeepOF to evaluate responses across sex and age. Our results show that responses to the second-order stimulus (CS(2)) specifically stem from its association with the first-order stimulus (CS(1)). While CS(1) triggers behavioral...

CONCLUSIONS AND IMPLICATIONS: These results suggest that AL and the FI are related, and that allostatic load may indeed contain "key" biomarkers of frailty. Given this, it is reasonable to suggest that AL could be used in at least an equivalent capacity to the FI currently and may represent a more practical and efficient measure of health and health risk.

ObjectivesSocial isolation has negative health implications for older adults and caregivers. We examine the interdependency of social isolation among community-dwelling Medicare beneficiaries and their primary caregivers.MethodsUsing data from the National Study of Caregiving and the National Health and Aging Trends Study (2015-2017, N = 522 dyads), we conducted actor-partner interdependence models to examine the dyadic associations between baseline social isolation and social isolation at...

The efficacy of biologics, such as peptide and protein drugs, is often limited by their short half-lives in vivo, necessitating repeated infusions to maintain therapeutic effects. Here, we demonstrate that long-lived CAR T cells can be leveraged as a versatile platform for long-term delivery of biologics. Our recent findings show that the depletion of BCOR and ZC3H12A induces GD2 CAR T cells into an immortal-like and functional state, which we have termed GD2T(IF) cells. These GD2T(IF) cells...

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BACKGROUND: The Hispanic Caribbean region is rapidly aging but national population-based aging surveys are rare. The Caribbean American Dementia and Aging Study (CADAS) is a multi-purpose household study of aging with a particular focus on the life course determinants and consequences of health and dementia in three countries with many similarities but divergent recent histories: Puerto Rico, Dominican Republic, and Cuba.

CONCLUSIONS: The results show a strong association between depression and malnutrition in older people. Malnutrition is a common occurrence among older people, and age is a significant risk factor. Similarly, depression is more common among older people living in nursing homes, and increasing age also raises depression levels. Therefore, future research should focus on conducting randomized, double-blind, placebo-controlled trials to confirm the effectiveness of nutritional interventions and...

CONCLUSION: This study demonstrates a substantial and consistent increase in the prevalence of self-reported cognitive disability among older adults in Botswana between 2017 and 2022. This sharp rise likely reflects a combination of measurement differences, changing cultural attitudes, real epidemiological shifts associated with an ageing population and rising non-communicable diseases, and possibly the broader impacts of the COVID-19 pandemic. These findings underscore the urgent need for...

Hematopoietic malignancies emerge through the acquisition of genetic mutations within hematopoietic stem and progenitor cells (HSPCs). Some mutations impart a selective growth advantage to HSPCs, which expand and contribute to mature blood cells. This expansion is termed clonal hematopoiesis (CH). Inhibitor of DNA binding 1 (ID1) protein is a transcriptional regulator of proliferation/differentiation of hematopoietic cells. HSPCs express low levels of Id1 that is induced by growth factors and...