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The forecasted prevalence of comorbidities and multimorbidity in people with HIV in the United States through the year 2030: A modeling study

3 months 3 weeks ago
CONCLUSIONS: The PEARL forecasts suggest a continued rise in comorbidity and multimorbidity prevalence to 2030, marked by heterogeneities across race/ethnicity, gender, and HIV acquisition risk subgroups. HIV clinicians must stay current on the ever-changing comorbidities-specific guidelines to provide guideline-recommended care. HIV clinical directors should ensure linkages to subspecialty care within the clinic or by referral. HIV policy decision-makers must allocate resources and support...
Keri N Althoff

Mathematical recapitulation of the end stages of human ovarian aging

3 months 3 weeks ago
Ovarian aging in women can be described as highly unpredictable within individuals but predictable across large populations. We showed previously that modeling an individual woman's ovarian reserve of primordial follicles using mathematical random walks replicates the natural pattern of growing follicles exiting the reserve. Compiling many simulations yields the observed population distribution of the age at natural menopause (ANM). Here, we have probed how stochastic control of primordial...
Sean D Lawley

Deterministic reprogramming of neutrophils within tumors

3 months 3 weeks ago
Science, Volume 383, Issue 6679, January 2024.
Melissa S. F. Ng, Immanuel Kwok, Leonard Tan, Changming Shi, Daniela Cerezo-Wallis, Yingrou Tan, Keith Leong, Gabriel F. Calvo, Katharine Yang, Yuning Zhang, Jingsi Jin, Ka Hang Liong, Dandan Wu, Rui He, Dehua Liu, Ye Chean Teh, Camille Bleriot,…