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NF-kappaB-mediated developmental delay extends lifespan in Drosophila

2 months 3 weeks ago
Developmental time (or time to maturity) strongly correlates with an animal's maximum lifespan, with late-maturing individuals often living longer. However, the genetic mechanisms underlying this phenomenon remain largely unknown. This may be because most previously identified longevity genes regulate growth rate rather than developmental time. To address this gap, we genetically manipulated prothoracicotropic hormone (PTTH), the primary regulator of developmental timing in Drosophila, to...
Ping Kang

# Language processing characteristics in normal pressure hydrocephalus: insights from eye-tracking analysis of incorrect responses

2 months 3 weeks ago
INTRODUCTION: In patients with Normal Pressure Hydrocephalus (NPH), the aging process results in decreased efficiency of cerebrospinal fluid circulation, leading to ventricular enlargement. This enlargement compresses several brain structures, impairing functions such as visual perception, semantic memory processing, and phonological encoding contributing to language processing difficulties. This study examines real-time language processing in NPH patients and healthy elderly (HE) controls by...
Ji-Yeong Kim

Bilateral neuromuscular adaptation to acute unilateral resistance exercise in healthy older adults

2 months 3 weeks ago
Resistance exercise (RE) enhances functionality in older adults and has proven effective as a means of cross-education in scenarios of unilateral disuse. However, the extent to which older adults demonstrate cross-limb transfer at the motor unit (MU) level following a single bout of unilateral RE is unclear. Thirteen healthy older adults (74.9 ± 4.8 years; 5 females) underwent bilateral neuromuscular assessments pre- and post- a single bout of unilateral RE consisting of sets of 12 repetitions...
Nishadi N Gamage

Measurements of molecular size and shape on a chip

2 months 3 weeks ago
Science, Volume 388, Issue 6747, May 2025.
Xin Zhu, Timothy J. D. Bennett, Konstantin C. Zouboulis, Dimitrios Soulias, Michal Grzybek, Justin L. P. Benesch, Afaf H. El-Sagheer, Ünal Coskun, Madhavi Krishnan

Mobile integrons encode phage defense systems

2 months 3 weeks ago
Science, Volume 388, Issue 6747, May 2025.
Nicolas Kieffer, Alberto Hipólito, Laura Ortiz-Miravalles, Paula Blanco, Thomas Delobelle, Patricia Vizuete, Francisco Manuel Ojeda, Thomas Jové, Dukas Jurenas, Meritxell García-Quintanilla, André Carvalho, Pilar Domingo-Calap, José Antonio Escudero