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Photosensitization enables Pauson-Khand–type reactions with nitrenes
Science, Volume 383, Issue 6682, Page 498-503, February 2024.
Local activation of CA1 pyramidal cells induces theta-phase precession
Science, Volume 383, Issue 6682, Page 551-558, February 2024.
Type III-B CRISPR-Cas cascade of proteolytic cleavages
Science, Volume 383, Issue 6682, Page 512-519, February 2024.
Terminal C(sp3)–H borylation through intermolecular radical sampling
Science, Volume 383, Issue 6682, Page 537-544, February 2024.
Accessing pluripotent materials through tempering of dynamic covalent polymer networks
Science, Volume 383, Issue 6682, Page 545-551, February 2024.
Functional traits—not nativeness—shape the effects of large mammalian herbivores on plant communities
Science, Volume 383, Issue 6682, Page 531-537, February 2024.
Computational phylogenetics reveal histories of sign languages
Science, Volume 383, Issue 6682, Page 519-523, February 2024.
Envisioning a radical future
Science, Volume 383, Issue 6682, Page 487-487, February 2024.
To infinity and beyond
Science, Volume 383, Issue 6682, Page 488-488, February 2024.
Clownfish may be capable of simple math
Study suggests the animals can add up stripes on other fish, though some experts are skeptical
On a remote Pacific island, clues to El Niño’s future are preserved in ancient reefs
Researchers exhume fossilized corals to predict the fate of a key climate pacemaker in a warmer world
News at a glance: Mars helicopter’s final flight, grants for U.K. diversity, and a nonopioid pain drug
The latest in science and policy
Pregnancy dramatically rewires every major organ, monkey study reveals
Vast atlas of chemical and hormonal changes could explain how humans adapt to pregnancy, offer clues for treating preeclampsia and other disorders
Daily briefing: New evidence supports controversial hypothesis of 'transmissible' Alzheimer's
No abstract
Clearance of β-amyloid and synapses by the optogenetic depolarization of microglia is complement selective
Microglia actively monitor the neighboring brain microenvironments and constantly contact synapses with their unique ramified processes. In neurodegenerative diseases, including Alzheimer's disease (AD), microglia undergo morphological and functional alterations. Whether the direct manipulation of microglia can selectively or concurrently modulate synaptic function and the response to disease-associated factors remains elusive. Here, we employ optogenetic methods to stimulate microglia in vitro...
An update on new-age potential biomarkers for Parkinson's disease
Parkinson's disease (PD) is a progressive neurodegenerative disorder that deals with dopaminergic deficiency in Substantia nigra pars compact (SNpc) region of the brain. Dopaminergic deficiency manifests into motor dysfunction. Alpha-synuclein protein aggregation is the source for inception of the pathology. Motor symptoms include rigidity, akinesia, tremor and gait dysfunction. Pre-motor symptoms are also seen in early stage of the disease; however, they are not distinguishable. Lack of early...
Impact of micronutrients and nutraceuticals on cognitive function and performance in Alzheimer's disease
Alzheimer's disease (AD) is a major global health problem today and is the most common form of dementia. AD is characterized by the formation of β-amyloid (Aβ) plaques and neurofibrillary clusters, leading to decreased brain acetylcholine levels in the brain. Another mechanism underlying the pathogenesis of AD is the abnormal phosphorylation of tau protein that accumulates at the level of neurofibrillary aggregates, and the areas most affected by this pathological process are usually the...
Effect of aging on the human myometrium at single-cell resolution
Age-associated myometrial dysfunction can prompt complications during pregnancy and labor, which is one of the factors contributing to the 7.8-fold increase in maternal mortality in women over 40. Using single-cell/single-nucleus RNA sequencing and spatial transcriptomics, we have constructed a cellular atlas of the aging myometrium from 186,120 cells across twenty perimenopausal and postmenopausal women. We identify 23 myometrial cell subpopulations, including contractile and venous capillary...
Why human brain cells grow so slowly
No abstract
Impact of micronutrients and nutraceuticals on cognitive function and performance in Alzheimer's disease
Alzheimer's disease (AD) is a major global health problem today and is the most common form of dementia. AD is characterized by the formation of β-amyloid (Aβ) plaques and neurofibrillary clusters, leading to decreased brain acetylcholine levels in the brain. Another mechanism underlying the pathogenesis of AD is the abnormal phosphorylation of tau protein that accumulates at the level of neurofibrillary aggregates, and the areas most affected by this pathological process are usually the...