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Global selection on insect antipredator coloration
Science, Volume 389, Issue 6767, Page 1336-1341, September 2025.
Fungus-farming termites can protect their crop by confining weeds with fungistatic soil boluses
Science, Volume 389, Issue 6767, Page 1366-1371, September 2025.
The phylogenetic position of the Yunxian cranium elucidates the origin of Homo longi and the Denisovans
Science, Volume 389, Issue 6767, Page 1320-1324, September 2025.
Lysosomes signal through the epigenome to regulate longevity across generations
Science, Volume 389, Issue 6767, Page 1353-1360, September 2025.
What to Expect When You're Dead: An Ancient Tour of Death and the Afterlife
Science, Volume 389, Issue 6767, Page 1299-1299, September 2025.
Why democracies die and what to do next
Science, Volume 389, Issue 6767, Page 1299-1299, September 2025.
The vitality of old age
Science, Volume 389, Issue 6767, Page 1298-1298, September 2025.
Ecuadorian scientists cleared of criminal charges in COVID-19 testing case
Prosecutors alleged officials and researchers defrauded government during the early months of the pandemic
Researchers are relieved at Trump’s likely pick for National Cancer Institute
Harvard physician-scientist Anthony Letai is poised to head world’s largest cancer research agency
How fungus-farming termites control weeds
Termites enlist microbes to defend their crops from undesirable fungi
Storied atom-smasher that makes tiny Big Bangs wraps up mission
For 26 years, the Relativistic Heavy Ion Collider has re-created the quark-gluon plasma that filled the infant universe
Thousands of quakes struck a major Greek volcano, mapping the plumbing beneath it
A “crisis” that rocked the island of Santorini may reveal a shared magma system between two volcanoes with explosive histories
Belgium program Enhancing the uptake and Effectiveness of a Multifactorial falls Prevention intervention in Older community-dWElling peRsons (BE-EMPOWERed): A study protocol
AIMS: This study protocol aims to outline a mixed-methods study of the implementation of the BE-EMPOWERed program in four primary care areas (PCAs) in Flanders. The study assesses implementation processes and outcomes, while exploring its effectiveness on clinical outcomes.
Gut-induced alpha-Synuclein and Tau propagation initiate Parkinson's and Alzheimer's disease co-pathology and behavior impairments
No abstract
CD103(-)CD8(+) T cells promote neurotoxic inflammation in Alzheimer's disease via granzyme K-PAR-1 signaling
Immune mechanisms contribute to the neuropathology of Alzheimer's disease (AD) but the role of adaptive immune cells is unclear. Here we show that the brain CD8^(+) T cell compartment is dysregulated in AD patients and in the 3xTg-AD mouse model, accumulating activated CD103^(-) tissue-resident memory T cells that produce large amounts of granzyme K (GrK). These CD103^(-)CD8^(+) T cells originate from the circulation and migrate into the brain using LFA-1 integrin. Ablation of brain...
Invasive neurophysiology and whole brain connectomics for neural decoding in patients with brain implants
Brain-computer interface research can inspire closed-loop neuromodulation therapies, promising spatiotemporal precision for the treatment of brain disorders. Decoding dynamic patient states from brain signals with machine learning is required to leverage this precision, but a standardized framework for invasive brain signal decoding from neural implants does not exist. Here we develop a platform that integrates brain signal decoding with magnetic resonance imaging connectomics and demonstrate...
The nuclear pore complex connects energy sensing to transcriptional plasticity in longevity
As the only gateway governing nucleocytoplasmic transport, the nuclear pore complex (NPC) maintains fundamental cellular processes and deteriorates with age. However, the study of age-related roles of single NPC components remains challenging owing to the complexity of NPC composition. Here, we demonstrate that the central energy sensor, AMP-activated protein kinase (AMPK), post-translationally regulates the abundance of the nucleoporin NPP-16/NUP50 in response to nutrient availability and...
D-galactose-induced aging and obese conditions contribute to aging and pathologies in dental pulp of male wistar rats
Our previous studies demonstrated that both D-galactose (D-gal)-mediated aging and high-fat diet (HF)-promoted obesity trigger inflammation, impair mitochondrial function in heart and brain, and disrupt bone homeostasis. However, the dental pulp pathologies in aging and obesity remain unclear. Insight into pulp biology under systemic conditions may facilitate strategies for maintaining pulp vitality. This study explored the effects of D-gal-mediated aging and HF-promoted obesity and...
Molecular marker of cochlear aging and hearing loss in primates
No abstract
She lived to 117: what her genes and lifestyle tell us about longevity
No abstract