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Publisher Correction: Revising the global biogeography of annual and perennial plants
Why don’t ants always fall for toxic bait? They may learn to avoid it
Results from Argentina suggest ants can catch on to traps
Is the world 1.3°C or 1.5°C warmer? Historical ship logs hold answers
Diverging estimates of 19th century ocean temperatures drive uncertainty over global warming
Planets around dead stars offer glimpse of the Solar System’s future—after the Sun swallows us up
By directly imaging planets around white dwarfs, NASA’s JWST telescope has opened a window to the future of the Sun
Puzzling prehistoric artifacts served a practical purpose: ropemaking
Once thought to be ritual wands or scepters, archaeologists crafted cords using replicas of the ancient tools
Daily briefing: Drugs such as Ozempic could help with Alzheimer's and Parkinson's
No abstract
Mask-inspired moisture-transmitting and durable thermochromic perovskite smart windows
Thermochromic perovskite smart windows (TPWs) are a cutting-edge energy-efficient window technology. However, like most perovskite-based devices, humidity-related degradation limits their widespread application. Herein, inspired by the structure of medical masks, a unique triple-layer thermochromic perovskite window (MTPW) that enable sufficient water vapor transmission to trigger the thermochromism but effectively repel detrimental water and moisture to extend its lifespan is developed. The...
SRF-deficient astrocytes provide neuroprotection in mouse models of excitotoxicity and neurodegeneration
Reactive astrogliosis is a common pathological hallmark of CNS injury, infection, and neurodegeneration, where reactive astrocytes can be protective or detrimental to normal brain functions. Currently, the mechanisms regulating neuroprotective astrocytes and the extent of neuroprotection are poorly understood. Here, we report that conditional deletion of serum response factor (SRF) in adult astrocytes causes reactive-like hypertrophic astrocytes throughout the mouse brain. These Srf^(GFAP-ER)CKO...
Implications of metabolism on multi-systems healthy aging across the lifespan
Aging is increasingly thought to involve dysregulation of metabolism in multiple organ systems that culminate in decreased functional capacity and morbidity. Here, we seek to understand complex interactions among metabolism, aging, and systems-wide phenotypes across the lifespan. Among 2469 adults (mean age 74.7 years; 38% Black) in the Health, Aging and Body Composition study we identified metabolic cross-sectionally correlates across 20 multi-dimensional aging-related phenotypes spanning seven...
Vitamin D(3) inhibits p38 MAPK and senescence-associated inflammatory mediator secretion by senescent fibroblasts that impacts immune responses during ageing
Vitamin D(3) replacement in older insufficient adults significantly improves their antigen-specific varicella zoster virus (VZV) cutaneous immunity. However, the mechanisms involved in this enhancement of cutaneous immunity are not known. Here, we show for the first time that vitamin D(3) blocks the senescence-associated secretory phenotype (SASP) production by senescent fibroblasts by partially inhibiting the p38 MAPK pathway. Furthermore, transcriptomic analysis of skin biopsies from older...
Osteoclasts and osteoarthritis: Novel intervention targets and therapeutic potentials during aging
Osteoarthritis (OA), a chronic degenerative joint disease, is highly prevalent among the aging population, and often leads to joint pain, disability, and a diminished quality of life. Although considerable research has been conducted, the precise molecular mechanisms propelling OA pathogenesis continue to be elusive, thereby impeding the development of effective therapeutics. Notably, recent studies have revealed subchondral bone lesions precede cartilage degeneration in the early stage of OA....
Correction to "A p21-GFP zebrafish model of senescence for rapid testing of senolytics in vivo"
No abstract