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BAP31 represses endoplasmic reticulum stress-mediated apoptosis and alleviates neurodegeneration in Parkinson's disease

2 months 2 weeks ago
Excessive endoplasmic reticulum (ER) stress and neuronal apoptosis contribute to neurodegeneration in Parkinson's disease (PD). However, the molecular mechanisms underlying these perturbations and how they are directly regulated remain unclear. B cell receptor-associated protein 31 (BAP31), which is highly expressed in the ER, has been shown to participate mainly in regulating ER stress and apoptosis. Here, our results showed that BAP31 expression was dramatically decreased in PD. Notably,...
Yan Qin

In-Hospital Professional Oral Health Management is Associated With Improved Outcomes in Older Adults With Acute Pneumonia

2 months 2 weeks ago
CONCLUSIONS AND IMPLICATIONS: POHM provided by hospital dentistry during the acute phase of pneumonia was significantly associated with improved clinical outcomes in older patients. These findings underscore the potential value of integrating hospital-based dental care into the multidisciplinary inpatient management of pneumonia in aging populations.
Takashi Ohi

Dipole-dipole interaction-induced dense primitive solid-electrolyte interphase for high-power Ah-level anode-free sodium metal batteries

2 months 2 weeks ago
High-energy and resource-abundant anode-free sodium metal batteries suffer from limited lifespan owing to dendrite growth and rapid capacity fading at early stages, particularly at high rate and high capacity. Here we report a preliminary surface-passivation strategy by highly fluorinated electrolyte, instantly forming a dense inorganic-dominant primitive solid-electrolyte interphase. Driven by dipole-dipole interaction, the spontaneously formed solid-electrolyte interphase is sufficiently dense...
Jiawen Huang