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Star ecologist accused of misconduct loses university post
Rapid in silico directed evolution by a protein language model with EVOLVEpro
Science, Volume 387, Issue 6732, January 2025.
Antarctic krill vertical migrations modulate seasonal carbon export
Science, Volume 387, Issue 6732, January 2025.
Identification of the subventricular tegmental nucleus as brainstem reward center
Science, Volume 387, Issue 6732, January 2025.
Highly multiplexed spatial transcriptomics in bacteria
Science, Volume 387, Issue 6732, January 2025.
Lysosomal dysfunction and inflammatory sterol metabolism in pulmonary arterial hypertension
Science, Volume 387, Issue 6732, January 2025.
Trump’s ban on funds to ‘promote gender ideology’ could threaten hundreds of NIH research projects
Sweeping executive order likely to be read broadly, experts predict
As Trump freeze continues, NIH gets a temporary leader
Agency sees pause on purchases, confusion about publishing, and the end of taxpayer-funded security for Anthony Fauci
Trump pause on foreign aid could threaten distribution of lifesaving drugs, experts say
Health experts worry about impact on major program to combat HIV
Put some wiggle in your mowing. Bees will love it
Cutting grass in ever-changing curves—rather than straight lines—could boost the abundance and diversity of pollinators
Trump tried to destroy a USDA think tank. Here’s what other U.S. agencies could learn from its fate
After the Economic Research Service was moved to Kansas City in 2019, staffing and productivity took a dive
Ancient Roman breastfeeding guidelines were followed closely in the cities—but not the hinterlands
Tooth chemistry shines a light on weaning practices across urban and rural communities in the Roman Empire
Trump’s shutdown of federal diversity office at NSF breaks law that created it
CHIPS and Science Act established position to broaden participation in science
Propagation of pathologic alpha-synuclein from kidney to brain may contribute to Parkinson's disease
The pathogenesis of Lewy body diseases (LBDs), including Parkinson's disease (PD), involves α-synuclein (α-Syn) aggregation that originates in peripheral organs and spreads to the brain. PD incidence is increased in individuals with chronic renal failure, but the underlying mechanisms remain unknown. Here we observed α-Syn deposits in the kidneys of patients with LBDs and in the kidney and central nervous system of individuals with end-stage renal disease without documented LBDs. In male mice,...
alpha-Synuclein deposition in the kidney may contribute to Parkinson's disease
No abstract
Editorial Expression of Concern: Telomere dysfunction and Atm deficiency compromises organ homeostasis and accelerates ageing
No abstract
Multiplexed single-cell imaging reveals diverging subpopulations with distinct senescence phenotypes during long-term senescence induction
Cellular senescence is a phenotypic state that contributes to the progression of age-related disease through secretion of pro-inflammatory factors known as the senescence-associated secretory phenotype (SASP). Understanding the process by which healthy cells become senescent and develop SASP factors is critical for improving the identification of senescent cells and, ultimately, understanding tissue dysfunction. Here, we reveal how the duration of cellular stress modulates the SASP in distinct...
Basal ganglia components have distinct computational roles in decision-making dynamics under conflict and uncertainty
The basal ganglia (BG) play a key role in decision-making, preventing impulsive actions in some contexts while facilitating fast adaptations in others. The specific contributions of different BG structures to this nuanced behavior remain unclear, particularly under varying situations of noisy and conflicting information that necessitate ongoing adjustments in the balance between speed and accuracy. Theoretical accounts suggest that dynamic regulation of the amount of evidence required to commit...
Painful diabetic neuropathy is associated with accelerated epigenetic aging
About one out of two diabetic patients develop diabetic neuropathy (DN), of these 20% experience neuropathic pain (NP) leading to individual, social, and health-economic burden. Risk factors for NP are largely unknown; however, premature aging was recently associated with several chronic pain disorders. DNA methylation-based biological age (DNAm) is associated with disease risk, morbidity, and mortality in different clinical settings. The purpose of this work was to study, for the first time,...
Age-related differences of subjective visual vertical perception in adults-a functional near-infrared spectroscopy study
CONCLUSION: Young individuals outperform the older individuals in SVV performance due to age-related differences in brain functional patterns during the execution of vertical perception judgment. Both age groups activate the right SMG and left SFGdor, but the older individuals additionally activate regions such as bilateral PoCG and right MFG. While young people exhibit right-brain dominance, the older people rely on bilateral cognitive resources, indicating bilateral dominance. Except for the...