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Rate and noise in human amygdala drive increased exploration in aversive learning
Mapping urban gullies in the Democratic Republic of the Congo
Thioester-mediated RNA aminoacylation and peptidyl-RNA synthesis in water
Ultrabroadband on-chip photonics for full-spectrum wireless communications
AI versus skin cancer: the future of dermatology diagnosis
Viral spread: how rumours surged in revolutionary France
Skin: preserving the health of a multi-talented organ
Retraction Note: Crystal structures of agonist-bound human cannabinoid receptor CB<sub>1</sub>
Oxidative stress response protein delays ovarian aging by promoting stress granule clearance
How did life get multicellular? Five simple organisms could have the answer
Five single-celled species that dabble in multicellularity
Bright city lights make birds around the world sing longer
New look at 1755 quake, Europe’s largest ever, may foretell Atlantic ‘ring of fire’
Analysis suggests Earth’s mantle is peeling from the crust in the eastern Atlantic, a possible sign of the ocean’s eventual closure
College sports policy prevents athletes’ deaths with sickle cell testing—but it could do more, study finds
New report recommends improved education and genetic counseling alongside NCAA’s mandated screening
AI tool labels more than 1000 journals for ‘questionable,’ possibly shady practices
New algorithm could help scientists avoid publishing in shady titles
Remembering Rainer Weiss, inventor of the gravitational wave detector
Beloved physicist sketched out the concept that would lead to one of the biggest discoveries in physics and astronomy
Risk factors associated with cognitive frailty development through different transition pathways among community-dwelling older adult Japanese individuals: insights from the NILS-LSA project
CONCLUSIONS: Tailoring intervention strategies according to specific health statuses of older adults may prevent and delay CF onset and facilitate recovery from MCI and PF.
Molecular and genetic landscapes of retina and brain microglia in neurodegenerative diseases
Microglia-driven dysregulation has emerged as a significant underlying mechanism in many neurodegenerative diseases, such as age-related macular degeneration (AMD) and Alzheimer's disease (AD). Although both brain and retinal microglia originate from the yolk sac, it is uncertain whether they share molecular similarities or genetic and molecular foundations related to neurodegenerative diseases. In this study, we examine the transcriptomic and epigenetic profiles of retina and brain microglia...
RABGAP1 is a sensor that facilitates the sorting and processing of amyloid precursor protein
A hallmark of Alzheimer's disease (AD) is the accumulation of extracellular amyloid-β plaques in the brain. Amyloid-β is a 40-42 amino acid peptide generated by proteolytic processing of amyloid precursor protein (APP) via membrane-bound proteases. APP is a transmembrane protein, and its trafficking to sites of proteolysis represents a rate-limiting step in AD progression. Although APP processing has been well-studied, its trafficking itinerary and machinery remain incompletely understood. To...
Distinct manifestations of excitatory-inhibitory imbalance associated with amyloid-beta and tau in patients with Alzheimer's disease
A growing body of evidence shows that epileptic activity is frequently observed in patients with Alzheimer's disease (AD), implicating underlying excitatory-inhibitory imbalance. The distinction of whether the AD-epileptic phenotype represents a subset of patients or an underdiagnosed manifestation holds major therapeutic implications. Here, we quantified the excitatory-inhibitory imbalance in AD patients using magnetoencephalography and examined the relationships to AD...