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Daily briefing: Bite marks on bones hint that Romans really did fight lions
Daily briefing: Fibromyalgia eases after doses of gut microbes
Hundreds more NSF grants terminated after agency director resigns
Huge reproducibility project fails to validate dozens of biomedical studies
My ‘woke DEI’ grant has been flagged for scrutiny. Where do I go from here?
This is <i>not</i> the new colour that scientists have created
Audio long read: Do smartphones and social media really harm teens’ mental health?
‘Tatooine’-like planet orbits two stars ― but at a weird angle
A well-connected Earth: The science and conservation of organismal movement
Science, Volume 388, Issue 6745, April 2025.
Structural mechanism of LINE-1 target-primed reverse transcription
Science, Volume 388, Issue 6745, April 2025.
Base-modified nucleotides mediate immune signaling in bacteria
Science, Volume 388, Issue 6745, April 2025.
Tumor-derived erythropoietin acts as an immunosuppressive switch in cancer immunity
Science, Volume 388, Issue 6745, April 2025.
Emergence and interstate spread of highly pathogenic avian influenza A(H5N1) in dairy cattle in the United States
Science, Volume 388, Issue 6745, April 2025.
Distinct adipose progenitor cells emerging with age drive active adipogenesis
Science, Volume 388, Issue 6745, April 2025.
Vaccine experts band together to counter U.S. government misinformation
Vaccine Integrity Project intends to provide scientific responses to ill-founded vaccine moves
‘A huge honor’: China reveals the foreign scientists awarded rare lunar samples
Seven teams in six nations to get lunar material brought to Earth by the Chang’e-5 mission
Oldest ant fossil ever found reveals history of ‘hell ants’
Unusual Brazilian specimen trapped in limestone is 113 million years old
Transcriptional regulation by PHGDH drives amyloid pathology in Alzheimer's disease
Virtually all individuals aged 65 or older develop at least early pathology of Alzheimer's disease (AD), yet most lack disease-causing mutations in APP, PSEN, or MAPT, and many do not carry the APOE4 risk allele. This raises questions about AD development in the general population. Although transcriptional dysregulation has not traditionally been a hallmark of AD, recent studies reveal significant epigenomic changes in late-onset AD (LOAD) patients. We show that altered expression of the LOAD...
Chemical imaging delineates Abeta plaque polymorphism across the Alzheimer's disease spectrum
Amyloid-beta (Aβ) plaque formation in Alzheimer's disease (AD) pathology is morphologically diverse. Understanding the association of polymorphic Aβ pathology with AD pathogenesis and progression is critical in light of emerging Aβ-targeting therapies. In this work, functional amyloid microscopy enhanced by deep learning was integrated with mass spectrometry imaging to delineate polymorphic plaques and to identify their associated Aβ make-up. In both sporadic AD (n = 12) and familial AD (n = 6),...
Parkinson's gut-microbiota links raise treatment possibilities
No abstract