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Epigenetic age acceleration predicts subject-specific white matter degeneration in the human brain

3 weeks 4 days ago
Epigenetic clocks provide powerful tools for estimating health and lifespan but their ability to predict brain degeneration and neuronal damage during the aging process is unknown. In this study, we use GrimAge, an epigenetic clock correlated to several blood plasma proteins, to longitudinally investigate brain cellular microstructure in axonal white matter from a cohort of healthy aging individuals. A specific focus was made on white matter hyperintensities, a visible neurological manifestation...
Benjamin T Newman

In Science Journals

3 weeks 4 days ago
Science, Volume 386, Issue 6725, Page 983-985, November 2024.

Michael Funk, and
Yevgeniya Nusinovich,
Ekeoma Uzogara,
Sacha Vignieri,
Jelena Stajic,
Marc S. Lavine,
Claire Olingy,
Jesse Smith,
Catherine Charneski,
Di Jiang,
Ian S. Osborne,
Mattia Maroso,
Stella M. Hurtley,
Caroline Ash,
Yury…

Eating the Earth

3 weeks 4 days ago
Science, Volume 386, Issue 6725, Page 956-967, November 2024.

Joel K. Bourne

News at a glance

3 weeks 4 days ago
Science, Volume 386, Issue 6725, Page 948-949, November 2024.

Jeffrey Brainard