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Multimodal prediction of MCI-to-dementia conversion over a two-year window
Mild cognitive impairment (MCI) represents a heterogeneous clinical state where some individuals remain stable while others progress to dementia. Identification of patients who are at high risk for near-term conversion remains a critical challenge for timely intervention. We developed an explainable multimodal machine-learning framework to predict progression from MCI to dementia within a clinically meaningful two-year period. We analyzed 2008 samples from 828 unique MCI subjects from the...
Gait Speed and Survival in Those With Exceptional Longevity: The LifeAfter90 Study
CONCLUSION: Faster gait speed was associated with a lower risk of mortality in adults aged 90 and older. These results were consistent across gender, race/ethnicity, and assistive device use, but differed by age group. Routine gait speed assessment may serve as a simple clinical tool to identify oldest-old adults at higher risk of mortality.
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