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Daily briefing: Mysterious Taiwan fossil is Denisovan
NIH cuts triggered a host of lawsuits: <i>Nature</i>’s guide to what’s next
Liquids in a glass recover a graceful shape even after being shaken
Mystery of medieval manuscripts revealed by ancient DNA
Pre-symptomatic Parkinson’s disease blood test quantifying repetitive sequence motifs in transfer RNA fragments
Author Correction: Sulfide-rich continental roots at cratonic margins formed by carbonated melts
Structural pathway for PI3-kinase regulation by VPS15 in autophagy
Science, Volume 388, Issue 6743, April 2025.
A neuroimmune circuit mediates cancer cachexia-associated apathy
Science, Volume 388, Issue 6743, April 2025.
Rules of engagement for condensins and cohesins guide mitotic chromosome formation
Science, Volume 388, Issue 6743, April 2025.
The genetic architecture of and evolutionary constraints on the human pelvic form
Science, Volume 388, Issue 6743, April 2025.
A distinct priming phase regulates CD8 T cell immunity by orchestrating paracrine IL-2 signals
Science, Volume 388, Issue 6743, April 2025.
Retrograde mitochondrial signaling governs the identity and maturity of metabolic tissues
Science, Volume 388, Issue 6743, April 2025.
Chief of NIH’s international center is latest director to lose job under Trump
Kathleen Neuzil had led the Fogarty International Center for less than 1 year
Sexual orientation, gender options cut from U.S. Ph.D. graduate survey
After adding questions to a key survey last year, the U.S. National Science Foundation is reversing course
After Trump grant cuts, some universities give researchers a lifeline
“Bridge” programs are temporary help, officials say, but no substitute for sustained federal funding
Astronomers spot a planetary ‘suicide’
World seen plunging into its star for the first time
CDC firings gut research on traumatic brain injuries
Last week’s mass layoffs removed small team studying concussions
Did cult sacrifices in ancient Egypt give rise to the cat?
“Murder pathway” may have tamed wildcats over several generations
A cloaked human stem-cell-derived neural graft capable of functional integration and immune evasion in rodent models
Human pluripotent stem cell (hPSC)-derived therapies are a realistic possibility for numerous disorders, including Parkinson's disease. While generating replacement neurons is achievable, immunosuppressive drug challenges, to prevent rejection, remain. Here we adopted a hPSC line (termed H1-FS-8IM), engineered to overexpress 8 immunomodulatory transgenes, to enable transplant immune evasion. In co-cultures, H1-FS-8IM PSC-derived midbrain neurons evaded rejection by T lymphocytes, natural killer...
Subthalamic nucleus dynamics during executive functioning: Insights from local field potentials in Parkinson's disease
This study explores the involvement of the subthalamic nucleus (STN) in executive functions, particularly cognitive flexibility, in Parkinson's disease (PD) patients. Utilizing a computerized Wisconsin Card Sorting Task (WCST) and local field potential (LFP) recordings from implanted deep brain stimulation (DBS) electrodes, we investigated task-specific neural dynamics. Behavioural results demonstrated increased error rates and prolonged response times in trials requiring set-shifting and rule...