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Over the past five years, systemic NAD^(+) (nicotinamide adenine dinucleotide) decline has been accepted to be a key driving force of aging in the field of aging research. The original version of the NAD World concept was proposed in 2009, providing an integrated view of the NAD^(+)-centric, systemic regulatory network for mammalian aging and longevity control. The reformulated version of the concept, the NAD World 2.0, was then proposed in 2016, emphasizing the importance of the inter-tissue...

Alternative splicing impacts most multi-exonic human genes. Inaccuracies during this process may have an important role in ageing and disease. Here, we investigate splicing accuracy using RNA-sequencing data from >14k control samples and 40 human body sites, focusing on split reads partially mapping to known transcripts in annotation. We show that splicing inaccuracies occur at different rates across introns and tissues and are affected by the abundance of core components of the spliceosome...

CONCLUSIONS: Superaging brains manifested maintained neurobiological youthfulness in terms of a more youthful brain aging status and a reduced speed of brain aging. These findings suggest that cognitive resilience, and potentially broader functional resilience, exhibited by superagers during the aging process may be attributable to their younger brains.

CONCLUSION: The global burden of Parkinson's disease has risen over the past 32 years, and there is a need to focus on key populations, as well as to improve health policies to prevent and treat Parkinson's disease.

Seismologist Susan Hough chats with Science about her attempts to debunk a local legend

Memo from acting director to staff allows some purchasing, and suggests travel and study sections could soon resume

Rena D’Souza will retire on 31 January

Little powerhouses might someday replace billion-dollar, kilometer-long behemoths at major x-ray facilities

CONCLUSION: APOE4 may link PD and AD through shared genetic variants, inflammatory pathways, and dyslipidemia, involving both peripheral and central pathways. More comprehensive studies are required to ascertain the relationship between PD, AD, and APOE4, and to determine whether these associations are causal or non-causal in nature.