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Structural and functional characterization of human sweet taste receptor
Publisher Correction: Transposable element methylation tracks age
How to make America healthy: the real problems — and best fixes
We need to predict the people disasters will hit, not just the places
Celebrating the anniversary of Michael Faraday’s discovery of benzene
Adversarial collaborations: all theories must be subject to critical evaluation
Make the study of human flourishing a global priority
‘Harm’ must not be redefined by US conservation agencies
House Democrats slam RFK Jr. for research funding cuts, vaccine policy
Health secretary claims to be unaware of letter of protest from 300 of his agency’s scientists
A single shot of a flu drug could outperform vaccines—and protect for an entire season
One injection of a long-lasting drug showed up to 76% efficacy in a large trial
Mountain-dwelling animals may have a worse sense of smell
Poor olfaction could be an adaptation to frigid environments
Roman gravestones hint that ancient economies still shape the present
A computer analysis of Latin inscriptions argues that economic complexity is “sticky” over time. Historians are skeptical
Sound policy demands sound science
Science, Volume 389, Issue 6755, Page 7-7, July 2025.
Sluggishness and defensiveness helped enable an executive order on research integrity
Science, Volume 389, Issue 6755, Page 9-9, July 2025.
Rubin observatory unveils first images taken with its giant mirror and camera
Pictures are a prelude to a transformative, all-sky survey set to begin in months
Killer whales groom each other—with pieces of kelp
In a newly discovered form of social tool use, orcas scratch each other’s backs with seaweed
Comprehensive evaluation of plasma tau biomarkers for detecting and monitoring Alzheimer's disease in a multicenter and multiethnic aging population
Over 20% of patients with Alzheimer's disease (AD) worldwide are Chinese, although the efficacy of existing blood-based measures of AD biomarkers is largely unknown in Asian cohorts. Here we explored how plasma tau biomarkers correlated with cross-sectional and longitudinal AD-related outcomes and their diagnostic performance in 1,085 participants from three independent studies, including two Chinese cohorts, Greater-Bay-Area Healthy Aging Brain Study (n = 425) and Huashan (n = 297), and the...
Differential effects of concentric and eccentric contractions on the primary motor cortex in healthy young and elderly participants
CONCLUSION: This study is the first to investigate cortical activity during eccentric lower limb contractions in older adults. The results suggest that eccentric contractions induce greater cortical activation compared to concentric, even in older adults who generally exhibit reduced cortical activity. These findings support the potential of eccentric as an effective intervention to improve motor function and muscle strength in older adults.
Normal and slow learners: a new discriminative method based on the speed of spatial learning in aged mice
Aging is accompanied by a decline in cognitive functions, including spatial memory, yet significant variability exists in the learning abilities of older individuals. Using a large cohort of aged and young male mice, we employed spatial discrimination testing in an 8-arm radial maze to investigate age-related differences in performance in spatial learning and to categorize individual memory phenotypes within the aged population. Despite a general learning ability across groups, aged mice showed...
Association of professional environment with loneliness and perceived social isolation among individuals in their second half of life
CONCLUSIONS: Enterprising professions in particular may assist in avoiding perceived social isolation, pending longitudinal evidence. Studies from other countries are recommended.