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Targeting cancer with small-molecule pan-KRAS degraders

3 months ago
Science, Volume 385, Issue 6715, Page 1338-1347, September 2024.
Johannes Popow, William Farnaby, Andreas Gollner, Christiane Kofink, Gerhard Fischer, Melanie Wurm, David Zollman, Andre Wijaya, Nikolai Mischerikow, Carina Hasenoehrl, Polina Prokofeva, Heribert Arnhof, Silvia Arce-Solano, Sammy Bell, Georg Boeck,…

The rat’s tale

3 months ago
Science, Volume 385, Issue 6715, Page 1281-1281, September 2024.

Christos Lynteris

Model citizens

3 months ago
Science, Volume 385, Issue 6715, Page 1282-1282, September 2024.

Ian J. Davidson

The interplay between probiotics and host autophagy: mechanisms of action and emerging insights

3 months ago
Autophagy, a lysosome-dependent protein degradation mechanism, is a highly conserved catabolic process seen in all eukaryotes. This cell protection system, which is present in all tissues and functions at a basic level, can be up- or downregulated in response to various stresses. A disruption in the natural route of the autophagy process is frequently followed by an interruption in the inherent operation of the body's cells and organs. Probiotics are live bacteria that protect the host through...
Zahra Sadeghloo