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Poly(ADP-ribose) (PAR) polymerase 1 (PARP1) has been implicated in DNA damage responses and neuroinflammation in Alzheimer's disease (AD), yet its role in amyloid-beta (Aβ) pathology remains unclear. Here, we show that PARP1 activation drives Aβ pathology and neurodegeneration. Using a sensitive enzyme-linked immunosorbent assay, we observed significantly elevated PAR levels in the cerebrospinal fluid (CSF) of patients with mild cognitive impairment (MCI) and AD compared to controls. In vitro,...

CONCLUSIONS: Self-reported driving concerns demonstrate predictive validity for future crashes, but a substantial minority of crash-involved drivers remain undetected by self-report. Education and TMT-B performance may serve as clinically actionable markers for identifying these "silent" at-risk drivers.

The global increase in neurodegenerative disorders such as Alzheimer's disease has prompted the search for effective non-pharmacological interventions. Chrono-exercise which is the physical training aligned with circadian rhythms has emerged as a novel strategy to strengthen cognitive resilience. This study explores the impact of chrono-exercises, incorporating aerobic, resistance, and combined modalities, performed at the early dark (ZT13) and early light (ZT1) phases in an aluminum chloride...

Critics say proposal was rushed and could endanger the animals

A casual conversation between graduate students helped spark a breakthrough in aging research at Mayo Clinic. Researchers discovered that tiny synthetic DNA molecules called aptamers can selectively attach to senescent “zombie cells,” which are linked to aging, cancer, and neurodegenerative disease. The method could eventually help scientists identify and target these cells in living tissue with far greater precision.

Scientists are uncovering a surprising link between hidden tooth infections and blood sugar problems. Deep infections around tooth roots can create chronic inflammation that spreads through the body and may interfere with insulin function. Studies found that people who underwent root canal treatment often experienced better blood sugar control and reduced inflammation afterward. The research suggests that treating an infected tooth could have benefits far beyond the mouth.

A groundbreaking Swedish study that tracked people for nearly 50 years has revealed when the body’s physical decline quietly begins. Researchers found that fitness, strength, and muscle endurance start slipping around age 35, with the decline accelerating over time. But there’s an encouraging twist: adults who became active later in life still improved their physical performance by up to 10 percent.

Colorectal cancer is increasingly showing up in younger adults, with cases now appearing in people as young as their thirties — often with no family history or warning signs. A major Swiss study analyzing nearly 100,000 cases over four decades found that diagnoses in people under 50 have been steadily climbing, even as rates fall among older adults thanks to screening programs. Researchers say younger patients are also more likely to be diagnosed late, after the cancer has already spread.

A daily multivitamin may help slow biological aging, according to researchers studying older adults in a large clinical trial. After two years, participants taking multivitamins showed slower aging in several DNA-based “epigenetic clocks,” with the effect equal to about four months less biological aging. People who started out biologically older than their actual age appeared to benefit the most. The findings hint that a simple supplement could play a role in healthier aging.