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Fat plays a key role in maintaining energy balance and supporting various physiological processes. HuAge-related disorders in fat utilization are increasingly prevalent, contributing to impaired energy balance, heightened metabolic disease risk, and increased cardiovascular dysfunction. The mechanism of age-induced disorders of fat utilization remains unclear. This study aims to explore the key factor affecting fat digestion and absorption during aging. Mice of different ages were used to...

Skeletal muscle aging is characterized by progressive functional decline and molecular remodeling, yet how different muscle types respond to aging remains incompletely understood. Here, we performed integrated transcriptomic and metabolomic profiling of three functionally distinct muscles-gastrocnemius (GA), soleus (SOL), and tibialis anterior (TA)-from young (3-month) and aged (24-month) C57BL/6J male mice. Our multi-omics approach revealed both shared and muscle-specific molecular signatures...

PINK1-dependent activation of PRKN/parkin on depolarized mitochondria causes mitophagy. The deficiency of NME3, a nucleoside diphosphate kinase/NDPK on the outer mitochondria membrane (OMM), is associated with a fatal neurodegenerative disorder. Here, we report that NME3 deficiency impairs p-S65-ubiquitin (Ub)-dependent PRKN binding on depolarized mitochondria without involving the loss of Ub phosphorylation by PINK1. Our mechanistic investigation revealed that NME3 interacts with PLD6/MitoPLD...

The changing demography of human populations has motivated a search for interventions that promote healthy ageing, and especially for evolutionarily-conserved mechanisms that can be studied in lab systems to generate hypotheses about function in humans. Reduced Insulin/IGF signalling (IIS) is a leading example, which can extend healthy lifespan in a range of animals, but whether benefits and costs of reduced IIS vary genetically within species is under-studied. This information is critical for...

Alzheimer's disease (AD) represents a continuously advancing neurodegenerative condition distinguished by the unremitting deterioration of cognitive abilities and memory impairment, which significantly hampers daily functioning of life. In the absence of disease modifying treatments, it continues to pose a significant global challenge. Though symptomatic treatment exists, the inherent complexity involved with AD pathogenesis related to Aβ plaques, neurofibrillary tangles, neuroinflammation,...

New energy-absorbing designs and materials have revolutionized the iconic safety device

Science, Volume 391, Issue 6785, February 2026.

Science, Volume 391, Issue 6785, February 2026.

Science, Volume 391, Issue 6785, February 2026.

Science, Volume 391, Issue 6785, February 2026.

Science, Volume 391, Issue 6785, February 2026.

Science, Volume 391, Issue 6785, February 2026.

Science, Volume 391, Issue 6785, February 2026.

Science, Volume 391, Issue 6785, February 2026.