Aggregator
Impaired hematopoiesis and embryonic lethality at midgestation of mice lacking both lipid transfer proteins VPS13A and VPS13C
VPS13 is the founding member of a family of proteins that mediate lipid transfer at intracellular membrane contact sites by a bridge-like mechanism. Mammalian genomes comprise 4 VPS13 genes encoding proteins with distinct localizations and function. The gene duplication resulting in VPS13A and VPS13C is the most recent in evolution and, accordingly, these two proteins are the most similar to each other. However, they have distinct subcellular localizations and their loss of function mutations in...
PI31 expression is neuroprotective in a mouse model of early-onset parkinsonism
Neurodegenerative diseases present one of the most significant global health challenges. These disorders are defined by the accumulation of abnormal protein aggregates that impair synaptic function and cause progressive neuronal degeneration. Therefore, stimulating protein clearance mechanisms may be neuro-protective. Variants in FBXO7/PARK15 cause Parkinsonian Pyramidal Syndrome, an early-onset parkinsonian neurodegenerative disorder in humans, and inactivation of this gene in mice...
Daily briefing: A ‘time crystal’ made visible to the naked eye
Mysterious changes near Earth’s core revealed by satellites in space
Rare comet photobombs telescope’s view of the cosmos
Make trains great again — for the sake of people and the planet
Equity in science is a beautiful lie — and I’m done pretending
How billions of hacked mosquitoes and a vaccine could beat the deadly dengue virus
‘Revolutionary’ AI tools rescue old weather data to improve climate models
Mysterious mass deaths of an extinct giant deer
Gone with the wind: deciphering how dandelions drive seed dispersal
Publisher Correction: TCF1 and LEF1 promote B-1a cell homeostasis and regulatory function
Delta-type glutamate receptors are ligand-gated ion channels
How did assaults on science become the norm — and what can we do?
Coordinate to combat Pakistan’s climate-driven disasters
A population plunge could help to mitigate the global biodiversity crisis
Impoundment of funds endangers US investment in science and medical research
Fertility declines are no cause for concern, history shows
Notorious ex–weapons factory will lock up nuclear waste in glass—if the White House lets it
Hanford vitrification plant set to open but some fear Trump officials are pushing for a cheaper alternative
House panels charge U.S. National Academies with producing partisan studies
Pending spending bill urges agencies to find other sources of scientific advice