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Immunosuppressive macrophages determine the effect of cellular senescence on tumor progression
Cells terminally arrested in the cell cycle that exhibit a distinct secretory phenotype are referred to as senescent. These cells play a complex role during tumor progression; they can inhibit or promote tumor growth depending on disease stage. We developed a mouse model that allows monitoring and selective elimination of cells expressing high levels of the cyclin-dependent kinase inhibitor p16 and interleukin-6. These mice, termed SuSe (suicidal senescence), were crossed with the mouse mammary...
Blood-cleansing method faces its first test as cancer vaccine
New clinical trial aims to use whole, light-inactivated tumor cells for immunotherapy
Adherence to healthy dietary patterns and risk of premature aging in adult survivors of childhood cancer in the St. Jude Lifetime Cohort Study
CONCLUSION: Adherence to a healthy diet may contribute to reducing the premature aging risk in adult survivors of childhood cancer. Interventions that support healthy eating in this population could potentially have benefits for long-term health outcomes.
Magical thinking will not prevent future pandemics or improve public health
Science, Volume 391, Issue 6780, January 2026.
Erratum for the Research Article “Convergent acquisition of disulfide-forming enzymes in malodorous flowers” by Y. Okuyama et al.
Science, Volume 391, Issue 6780, January 2026.
Duck-billed dinosaur fleshy midline and hooves reveal terrestrial clay-template “mummification”
Science, Volume 391, Issue 6780, January 2026.
Asynchronous subunit transitions prime acetylcholine receptor activation
Science, Volume 391, Issue 6780, January 2026.
SPARK-seq: A high-throughput platform for aptamer discovery and kinetic profiling
Science, Volume 391, Issue 6780, January 2026.
De novo design of small molecule–regulated protein oligomers
Science, Volume 391, Issue 6780, January 2026.
Genomic and morphometric evidence for Austronesian-mediated pig translocation in the Pacific
Science, Volume 391, Issue 6780, January 2026.
Limiting phosphonic acid interlayer–perovskite reactivity to stabilize perovskite solar modules
Science, Volume 391, Issue 6780, January 2026.
Neural basis of cooperative behavior in biological and artificial intelligence systems
Science, Volume 391, Issue 6780, January 2026.
Science in 2026: what to expect this year
In Science Journals
Science, Volume 391, Issue 6780, Page 42-44, January 2026.
Translating climate science into legal standards: Lessons from the Milieudefensie v. Shell case
Science, Volume 391, Issue 6780, Page 26-29, January 2026.
Resisting AI slop
Science, Volume 391, Issue 6780, Page 5-5, January 2026.
Sun-size lens could reveal alien continents and oceans
Science, Volume 391, Issue 6780, Page 11-12, January 2026.
Man in the middle
Science, Volume 391, Issue 6780, Page 16-19, January 2026.
AI threatens to upend online social science research
Science, Volume 391, Issue 6780, Page 8-9, January 2026.
Hack reveals reviewer identities for huge AI conference
Science, Volume 391, Issue 6780, Page 14-15, January 2026.