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Biden’s lean science budget could mean tough choices for agencies
President abides by tight spending cap in his 2025 request to Congress
Ancient graves reveal that facial piercing dates back at least 11,000 years
Daily briefing: Inside the room-temperature superconductivity scandal
Indigenous Australian fire-stick farming began at least 11,000 years ago
Dysregulated cellular stress management becomes a source of stress
First cell therapy for solid tumours heads to the clinic: what it means for cancer treatment
All-optical frequency division on-chip using a single laser
Why I wander with wonder through Lesotho’s wetlands
‘A beautiful way of saying a lot’: sign language brings benefits to the organic chemistry classroom
This geologist communicates science from the ski slopes
No installation required: how WebAssembly is changing scientific computing
Act now to prevent a ‘gold rush’ in outer space
The science of <i>Oppenheimer</i>: meet the Oscar-winning movie’s specialist advisers
Blockbuster obesity drug leads to better health in people with HIV
‘Damning’ FDA inspection report undermines positive trial results of possible Alzheimer’s drug
Inspectors faulted trial sample analyses by Hoau-Yan Wang, academic partner of Cassava Sciences
Amazing diversity of today’s ants tied to rise of flowering plants
The earliest ants went extinct, but more generalist species blossomed by taking advantage of the spread of plants that flower
Estimated prevalence of frailty and prefrailty in patients undergoing coronary artery or valvular surgeries/procedures: A systematic review and proportional meta-analysis
CONCLUSION: Frailty represents a considerable health challenge among patients undergoing cardiac surgeries/procedures. Routine screening for frailty should be considered during perioperative care planning.
Aging phenotype in AD brain organoids: Track to success and challenges
Alzheimer's disease (AD) poses a complex challenge, with abnormal protein accumulation in the brain causing memory loss and cognitive decline. Traditional models fall short in AD research, prompting interest in 3D brain organoids (BOs) from human stem cells. These findings hold promise for unveiling the mechanisms of AD, especially in relation to aging. However, an understanding of the aging impact of AD remains elusive. BOs offer insight but face challenges. This review delves into the role of...
Aging phenotype in AD brain organoids: Track to success and challenges
Alzheimer's disease (AD) poses a complex challenge, with abnormal protein accumulation in the brain causing memory loss and cognitive decline. Traditional models fall short in AD research, prompting interest in 3D brain organoids (BOs) from human stem cells. These findings hold promise for unveiling the mechanisms of AD, especially in relation to aging. However, an understanding of the aging impact of AD remains elusive. BOs offer insight but face challenges. This review delves into the role of...
Deficiency of skeletal muscle Agrin contributes to the pathogenesis of age-related sarcopenia in mice
Sarcopenia, a progressive and prevalent neuromuscular disorder, is characterized by age-related muscle wasting and weakening. Despite its widespread occurrence, the molecular underpinnings of this disease remain poorly understood. Herein, we report that levels of Agrin, an extracellular matrix (ECM) protein critical for neuromuscular formation, were decreased with age in the skeletal muscles of mice. The conditional loss of Agrin in myogenic progenitors and satellite cells (SCs) (Pax7 Cre::...