Aggregator
Cognitive aging clock based on Explainable artificial intelligence
Biological clocks aim to estimate the physiological state of an organism, or of specific organs or systems, from the perspective of aging. The inferred individual age acceleration is presumably linked to increased mortality and morbidity risks. Here, we introduce a cognitive aging clock based on a battery of five tests (sensomotor arithmetic, sensomotor mirror letter, 1-back, campimetry and the Stroop), capturing sensory and verbal perception, working memory, and decision-making in the context...
Contrasting pathways to tree longevity in gymnosperms and angiosperms
Tree longevity is thought to increase in growth-limiting, adverse environments, but a quantitative assessment of drivers of global variation in tree longevity is lacking. We assemble a global database of maximum longevity for 739 tree species and analyse associations between longevity and climate, soil, and species' functional traits. Our results show two primary pathways towards long lifespans. The first is slow growth in resource-limited environments, consistent with the "adversity begets...
Psychometric evaluation of the Chinese version of the biobehavioural pain and movement questionnaire (BioPMovQ) in elderly CMP patients
CONCLUSIONS: The Chinese version of BioPMovQ has good reliability and validity, and can be used to measure the relationship between pain and various factors related to exercise behavior in elderly patients with CMP from a biological behavioral perspective.
Exploring the concept of a "friendly relationship to death" in geriatric patients
CONCLUSION: Among geriatric patients, a FRD appears to prevail, extending beyond a neutral acceptance of death's inevitability and existing independently of suicidality, depression, frailty, or disease burden. Understanding a FRD may help contextualize older individuals' acceptance of aging and could impact geriatric treatment outcomes.
End-of-life healthcare utilization and costs according to cause of death: a retrospective study
CONCLUSION: This study highlights distinct EoL healthcare and social services utilization and related costs among older adults, depending on the cause of death, age, and sex. These findings underscore the need for tailored care strategies that reflect different EoL trajectories.
Agricultural or gardening physical activity may slow neurovascular aging and prevent stroke and dementia: an experimental and cross-sectional study
CONCLUSION: Our findings suggest that regular AGPA is associated with markers of slower neurovascular aging in older individuals. AGPA induces a combination of general physical activity-related and specific AGPA-related effects; moreover, it may offer similar or even greater benefits than physical activity alone. Therefore, habitual AGPA may serve as an effective preventive strategy for neurovascular aging.
Dogma-defying signalling through G proteins could lead to better pain relief
Point of no returns: researchers are crossing a threshold in the fight for funding
US–Africa bilateral health deals won’t help against diseases that ignore borders
Publisher Correction: Covalent targeted radioligands potentiate radionuclide therapy
Safeguards for military robotics are impeded by the realities of warfare
Science, Volume 390, Issue 6779, December 2025.
Erratum for the Research Article “Robust epitaxy of single-crystal transition-metal dichalcogenides on lanthanum-passivated sapphire” by X. Zou et al.
Science, Volume 390, Issue 6779, December 2025.
Erratum for the Report “TFEB links autophagy to lysosomal biogenesis” by C. Settembre et al.
Science, Volume 390, Issue 6779, December 2025.
Recent discoveries on the acquisition of the highest levels of human performance
Science, Volume 390, Issue 6779, December 2025.
A human pan-disease blood atlas of the circulating proteome
Science, Volume 390, Issue 6779, December 2025.
Ancient genomes illuminate the origins and dynamic history of East Asian cattle
Science, Volume 390, Issue 6779, December 2025.
Optimal perovskite vapor partitioning on textured silicon for high-stability tandem solar cells
Science, Volume 390, Issue 6779, December 2025.
Intracellular competition shapes plasmid population dynamics
Science, Volume 390, Issue 6779, December 2025.
Conformational landscape adaptations enable processive phosphorylation by Src family kinases
Science, Volume 390, Issue 6779, December 2025.
AQP5: A functional gastric cancer stem cell marker in mouse and human tumors
Science, Volume 390, Issue 6779, December 2025.