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Immunosuppressive macrophages determine the effect of cellular senescence on tumor progression

3 months ago
Cells terminally arrested in the cell cycle that exhibit a distinct secretory phenotype are referred to as senescent. These cells play a complex role during tumor progression; they can inhibit or promote tumor growth depending on disease stage. We developed a mouse model that allows monitoring and selective elimination of cells expressing high levels of the cyclin-dependent kinase inhibitor p16 and interleukin-6. These mice, termed SuSe (suicidal senescence), were crossed with the mouse mammary...
Marta Lalinde-Gutiérrez

In Science Journals

3 months ago
Science, Volume 391, Issue 6780, Page 42-44, January 2026.
Michael Funk, and Henk A. Dijkstra, Yury Suleymanov, Jelena Stajic, Jake S. Yeston, Madeleine Seale, Mark Aldenderfer, Wei Wong, Phil Szuromi, Mattia Maroso, Caroline Ash, Michael A Funk, Sacha Vignieri, Corinne Simonti, Yevgeniya Nusinovich, Keith T…