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Prophylactic use of azithromycin saves vulnerable children’s lives, but could trigger antibiotic resistance

Science chats with wildlife epidemiologist Tony Goldberg about what he’s learned from becoming a meal for parasites

Studies of rodents with a menstrual on/off switch could help people with endometriosis and other disorders

To obtain the toxic chemical cantharidin, insects suck beetles’ blood—and even munch on their digested remains

CONCLUSIONS: A negative eGFR(diff) (eGFR(cys)-eGFR(cr) < -15 mL/min/1.73m²) was associated with a higher risk of dementia, poorer cognitive functions, and worse biological age acceleration. While those with a positive eGFR(diff) had a lower risk.

Aging biomarkers play a vital role in understanding longevity, with the potential to improve clinical decisions and interventions. Existing aging clocks typically use blood, vitals, or imaging collected in a clinical setting. Wearables, in contrast, can make frequent and inexpensive measurements throughout daily living. Here we develop PpgAge, an aging clock using photoplethysmography at the wrist from a consumer wearable. Using the Apple Heart & Movement Study (n = 213,593 participants; >149...

CONCLUSION: Molecular signatures underlying regional vulnerability to AD provide a framework for understanding genetic and systemic factors in disease progression. Findings highlight specific molecular pathways, including ECM-related processes and hormonal regulation, as key drivers of susceptibility. Finally, identified drug repurposing candidates present promising therapeutic avenues for further investigation.

While the health effects of dietary copper intake have been widely studied, no research to date has specifically examined its association with biological aging. Here, we aim to explore the relationship between dietary copper intake and biological aging, while examining the mediating role of dietary inflammatory index (DII). This cross-sectional study included 18,160 adults from the 2003 to 2018 National Health and Nutrition Examination Survey (NHANES). Weighted multivariable linear regression...

Hutchinson-Gilford Progeria Syndrome (HGPS) is a fatal genetic disorder caused by progerin, a mutant lamin A variant that disrupts nuclear architecture and drives systemic cellular dysfunction. Gastrointestinal (GI) involvement in HGPS remains poorly understood, despite growing evidence of gut abnormalities and microbial dysbiosis in progeroid mouse models. Here, we provide the first comprehensive characterization of colonic pathology in Lmna^(G609G/G609G) mice and assess the therapeutic impact...

The advent of in vivo reprogramming through transient expression of the Yamanaka factors (OCT4, SOX2, KLF4, and c-MYC) holds strong promise for regenerative medicine, despite ongoing concerns about safety and clinical applicability. This review synthesizes recent advances in in vivo reprogramming, focusing on its potential to restore regenerative competence and promote rejuvenation across diverse tissues, including the retina, skeletal muscle, heart, liver, brain, and intestine. We highlight...

CONCLUSIONS AND IMPLICATIONS: This review and meta-analysis support that exercise training is an effective model of improving frailty levels among older adults in long-term care. Strategies to address the practical aspects of these programs are needed, but this study emphasizes that structured exercise should be a crucial aspect of long-term care.

CONCLUSIONS AND IMPLICATIONS: Our findings highlight the clinical importance of recognizing fatigue throughout the entire aging life span as an independent marker for subsequent negative health outcomes and mortality. Although fatigue might serve as a surrogate for intrinsic capacity, it remains unclear if fatigue is amenable to intervention.