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Energy spectrum of elusive particles shows an intriguing bump, giant IceCube experiment reports

Optogenetics is poised to move from a research tool to new therapies—if scientists can show it’s safe

Bark spider silk is stronger than steel, but males make a weaker version

Growing more common as climate warms, these once-rare events could ultimately accelerate ice loss

Replicability analysis is a cornerstone for identifying genuine genetic associations in genome-wide association studies (GWAS), yet existing methods are constrained by their failure to account for linkage disequilibrium (LD) structure among single nucleotide polymorphisms (SNPs) or underuse of auxiliary information, limiting their reliability and statistical power. We develop CARLIS, a comprehensive covariate-assisted replicability analysis method to enhance both statistical rigor and biological...

Timely and accessible tools for detecting preclinical Alzheimer's disease (AD) are essential for early intervention, yet reliance on MRI biomarkers limits scalability. Using longitudinal data from 210 cognitively normal older adults in ADNI, we compared the predictive value of verbal episodic memory, hippocampal volume, and a visuospatial composite. Over a 7-year window, 106 participants progressed to mild cognitive impairment (MCI), while 104 remained stable. At baseline, Immediate Recall on...

Timely and accessible tools for detecting preclinical Alzheimer's disease (AD) are essential for early intervention, yet reliance on MRI biomarkers limits scalability. Using longitudinal data from 210 cognitively normal older adults in ADNI, we compared the predictive value of verbal episodic memory, hippocampal volume, and a visuospatial composite. Over a 7-year window, 106 participants progressed to mild cognitive impairment (MCI), while 104 remained stable. At baseline, Immediate Recall on...

CONCLUSIONS: Findings support the SCT triadic reciprocal determinism: personal factors influence and are influenced by behavioral and environmental elements. Consequently, a multilevel strategy aligned with SCT, such as enhancing personal capacity, strengthening institutional support, and optimizing systemic safeguards, is essential to empower hospital-based healthcare professionals to intervene in elder abuse.

Fatty acids are involved in disease risk and aging processes. In the US National Health and Nutrition Examination Survey (1999-2002), we tested for associations of total, saturated (SFA), monounsaturated (MUFA), polyunsaturated (PUFA), and subtypes of dietary fatty acids with DNA methylation-based aging biomarkers, adjusting for age, BMI, total energy intake, and sociodemographic and behavioral factors (N = 2260). Higher SFA and MUFA were associated with greater GrimAge2, an aging biomarker of...