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Integrative Multiparametric Analysis of Circulating Cell-Free Nucleic Acids of Plasma in Healthy Individuals During Aging

2 months 4 weeks ago
Plasma circulating cell-free nucleic acids (ccfNAs) provide an exceptional source of information about an individual's health, yet their biology in healthy individuals during aging remains poorly understood. Here, we present the first integrative multiparametric analysis of the major types of plasma ccfNAs, including nuclear (ccfnDNA) and mitochondrial (ccfmtDNA) DNA, as well as ribosomal (ccfrRNA), messenger (ccfmRNA) and micro-RNA (ccfmiRNA) in 139 healthy donors aged 19-66 years. We focused...
Nicolas P Tessier

NRF2 pathway activation predicts poor prognosis in lung cancer: a cautionary note on antioxidant interventions

2 months 4 weeks ago
Lung cancer is a leading cause of cancer-related mortality worldwide. As an age-related disease, its pathogenesis is shaped by several molecular hallmarks of aging, including impaired DNA repair and diminished stress resilience. The transcription factor NRF2 (nuclear factor erythroid 2-related factor 2) is a master regulator of oxidative stress defense and cellular survival. While NRF2 activation is protective in aging tissues, it may also be exploited by cancer cells to promote tumor...
Zoltan Ungvari

Proteoglycan-4 (PRG4) serum concentration is lower in aged mice, and genetic deficiency impacts survival probability, blood parameters, and bone during aging

2 months 4 weeks ago
Proteoglycan 4 (PRG4) is a mucin-like glycoprotein best known as a boundary lubricant of articular cartilage; however, it also has anti-inflammatory, anti-fibrotic, and immunomodulatory properties. Loss-of-function mutations in the PRG4 gene in humans result in Camptodactyly-Arthropathy-Coxa vara-Pericarditis (CACP), a rare disease in which patients often require joint replacements at young ages. However, it remains unknown how circulating PRG4 levels change with age or how PRG4 deficiency...
Adam P Tanguay

Association between sarcopenic obesity and dementia in the Chinese elderly using different definitions of obesity: evidence from the CHARLS

2 months 4 weeks ago
CONCLUSION AND IMPLICATIONS: The findings from this cross-sectional study suggest that both possible sarcopenia and sarcopenic obesity are significantly associated with an increased risk of probable dementia among older adults residing in the community in China. Notably, the relationship between sarcopenic obesity and dementia appears to be more pronounced compared to either possible sarcopenia or obesity alone. Moreover, incorporating waist circumference alongside components of possible...
Lang Peng

Non-linear relationship between calf circumference and global cognition in Chinese population: a cross-sectional study of 12,102 Chinese older adults

2 months 4 weeks ago
CONCLUSION: This study demonstrated a non-linear relationship between CC and global cognition in older Chinese population. Furthermore, sex disparities are observed in the relationship between CC and global cognition, with a non-linear link evident in women but not in men. Older women with lower CC should actively participate in physical activity to maintain an appropriate CC and prevent cognitive decline.
Yuting Nie

Insights Into Cockayne Syndrome Type B: What Underlies Its Pathogenesis?

2 months 4 weeks ago
Cockayne Syndrome (CS) is an autosomal recessive disorder arising from mutations in either of two disease-associated genes, ERCC6 or ERCC8. CS patients exhibit cutaneous photosensitivity, neuropathological abnormalities, severe growth retardation, a distinctive facial appearance with pronounced sunken eyes, musculoskeletal anomalies, sensory impairment, and dental decay. Approximately 70% of all CS cases carry ERCC6 mutations; therefore, this review will focus solely on Cockayne Syndrome...
Ricardo Afonso-Reis