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Meet a worm that can stretch like an accordion
Found off the coast of a Spanish estuary, worm can contract its body to one-fifth its original length
Daily briefing: AI companions — friend or frenemy?
Medical AI trained on whopping 57 million health records
AI reveals title of ‘unreadable’ Vesuvius scroll for first time
How I honed my biopharma dealmaking and business-development skills after my PhD
Supportive? Addictive? Abusive? How AI companions affect our mental health
Make science more collegial: why the time for ‘adversarial collaboration’ has come
Cuts to US science will take a generation to repair — leaders must speak up now
Avian vandals demolish spring flowers
Naturally ornate RNA-only complexes revealed by cryo-EM
Molecular basis of SIFI activity in the integrated stress response
A kinase mediator of rhizobial symbiosis and immunity in <i>Medicago</i>
Can Germany rein in its academic bullying problem?
Manage releases of ‘forever chemicals’ in lab waste
Next CERN collider has community input
USAID’s shutdown: a crisis for sub-Saharan Africa
In science-for-policy design, one size doesn’t fit all
Trump moves to tighten rules on risky research on viruses, bacteria, and toxins
Executive order on gain-of-function experiments could chill research on infectious diseases, scientists say
‘Data manipulations’ alleged in study that paved the way for Microsoft’s quantum chip
Internal emails from 2021 reveal tensions among researchers hunting for elusive Majorana particle
Chimeric deubiquitinase engineering reveals structural basis for specific inhibition of the mitophagy regulator USP30
The mitochondrial deubiquitinase ubiquitin-specific protease (USP) 30 negatively regulates PINK1-parkin-driven mitophagy. Whether enhanced mitochondrial quality control through inhibition of USP30 can protect dopaminergic neurons is currently being explored in a clinical trial for Parkinson's disease. However, the molecular basis for specific inhibition of USP30 by small molecules has remained elusive. Here we report the crystal structure of human USP30 in complex with a specific inhibitor,...