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Direct approach to laser-powered fusion promises simpler power production
Experiments suggest that, with enough laser power, “direct drive” technique should produce energy gain
The brain area that lights up in prickly people
Daily briefing: ‘Feynman’s sprinkler’ spin mystery solved
Several transient binding events create a strong, adaptable interface between organelles
Synthesizing and identifying potential biomarkers to explore uncharted biochemistry
Science and government: can the power struggle ever end?
‘Obviously ChatGPT’ — how reviewers accused me of scientific fraud
First passages of rolled-up Herculaneum scroll revealed
Innovative funding systems are key to fighting inequities in African science
JWST is most in-demand telescope ever — leaving many astronomers in the cold
The world has warmed 1.5 °C, according to 300-year-old sponges
I started fossil hunting in my 60s — now I have more than 2,000 pieces
Surprise find: a blood-based immune system is discovered in the gut
Ivory artefacts’ origins revealed by telltale peptides
It’s time to admit that genes are not the blueprint for life
The mechanism of cuproptosis in Parkinson's disease
Parkinson's disease (PD) is a neurodegenerative disease with an increased morbidity. The pathogenesis PD has not been fully elucidated, and whatever mechanism is involved, it ultimately leads to dopamine (DA) neuronal apoptosis. Cuproptosis is a novel form of cell death. Its morphology, biochemical properties, and mechanism of action differ from known forms of cell death, such as apoptosis, autophagy, necrosis and pyroptosis. Copper binds to the lipoylated components of the tricarboxylic acid...
Cervical cancer could be eliminated: here’s how
Local structural preferences in shaping tau amyloid polymorphism
Tauopathies encompass a group of neurodegenerative disorders characterised by diverse tau amyloid fibril structures. The persistence of polymorphism across tauopathies suggests that distinct pathological conditions dictate the adopted polymorph for each disease. However, the extent to which intrinsic structural tendencies of tau amyloid cores contribute to fibril polymorphism remains uncertain. Using a combination of experimental approaches, we here identify a new amyloidogenic motif, PAM4...
Senescent cells and macrophages cooperate through a multi-kinase signaling network to promote intestinal transformation in Drosophila
Cellular senescence is a conserved biological process that plays a crucial and context-dependent role in cancer. The highly heterogeneous and dynamic nature of senescent cells and their small numbers in tissues make in vivo mechanistic studies of senescence challenging. As a result, how multiple senescence-inducing signals are integrated in vivo to drive senescence in only a small number of cells is unclear. Here, we identify cells that exhibit multiple features of senescence in a Drosophila...
Pharmacological interventions in human aging
Pharmacological interventions are emerging as potential avenues of alleviating age-related disease. However, the knowledge of ongoing clinical trials as they relate to aging and pharmacological interventions is dispersed across a variety of mediums. In this review we summarize 136 age-related clinical trials that have been completed or are ongoing. Furthermore, we establish a database that describe the trials (AgingDB, www.agingdb.com) keeping track of the previous and ongoing clinical trials,...