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Unraveling the brain's response to COVID-19: How SARS-CoV-2 afflicts dopaminergic neurons
COVID-19 patients often display dysfunctions of the nervous system, indicating an effect of SARS-CoV-2 on neural cells. Yang et al. now show that human stem-cell-derived dopaminergic neurons are susceptible to SARS-CoV-2, triggering inflammation and senescence. The study further identifies three FDA-approved drugs capable of reversing these cellular phenotypes.
Breaking the links between ageism and health: An integrated perspective
Ageism refers to prejudice, stereotypes or discrimination based on a person's actual or perceived chronological age. While ageism can affect people at all stages of the human lifespan, ageism against older adults has emerged as the most pervasive and potentially harmful. Much is now understood about how ageism can impact older people's health and wellbeing via structural, organisational, and provider level biases that threaten the provision of equitable and ethical healthcare. Negative attitudes...
Optimizing potassium polysulfides for high performance potassium-sulfur batteries
Potassium-sulfur batteries attract tremendous attention as high-energy and low-cost energy storage system, but achieving high utilization and long-term cycling of sulfur remains challenging. Here we show a strategy of optimizing potassium polysulfides for building high-performance potassium-sulfur batteries. We design the composite of tungsten single atom and tungsten carbide possessing potassium polysulfide migration/conversion bi-functionality by theoretical screening. We create two ligand...
Finding the point of no return for cellular senescence
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Dysfunctional lipid metabolism in ageing muscle: effects on glucose tolerance
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The SATB1-MIR22-GBA axis mediates glucocerebroside accumulation inducing a cellular senescence-like phenotype in dopaminergic neurons
Idiopathic Parkinson's disease (PD) is characterized by the loss of dopaminergic neurons in the substantia nigra pars compacta, which is associated with neuroinflammation and reactive gliosis. The underlying cause of PD and the concurrent neuroinflammation are not well understood. In this study, we utilize human and murine neuronal lines, stem cell-derived dopaminergic neurons, and mice to demonstrate that three previously identified genetic risk factors for PD, namely SATB1, MIR22HG, and GBA,...
The SATB1-MIR22-GBA axis mediates glucocerebroside accumulation inducing a cellular senescence-like phenotype in dopaminergic neurons
Idiopathic Parkinson's disease (PD) is characterized by the loss of dopaminergic neurons in the substantia nigra pars compacta, which is associated with neuroinflammation and reactive gliosis. The underlying cause of PD and the concurrent neuroinflammation are not well understood. In this study, we utilize human and murine neuronal lines, stem cell-derived dopaminergic neurons, and mice to demonstrate that three previously identified genetic risk factors for PD, namely SATB1, MIR22HG, and GBA,...
Xrp1 governs the stress response program to spliceosome dysfunction
Co-transcriptional processing of nascent pre-mRNAs by the spliceosome is vital to regulating gene expression and maintaining genome integrity. Here, we show that the deficiency of functional U5 small nuclear ribonucleoprotein particles (snRNPs) in Drosophila imaginal cells causes extensive transcriptome remodeling and accumulation of highly mutagenic R-loops, triggering a robust stress response and cell cycle arrest. Despite compromised proliferative capacity, the U5 snRNP-deficient cells...
An ancient tree’s oddball shape is revealed by an extraordinary fossil
Daily briefing: Autoimmune disease linked to X chromosome
Crackdown on skin-colour bias by fingertip oxygen sensors is coming, hints FDA
Israel is flooding Gaza’s tunnel network: scientists assess the risks
Building used by Marie Curie will be dismantled to erect cancer centre
Elon Musk’s Neuralink brain chip: what scientists think of first human trial
‘Blue foods’ to tackle hidden hunger and improve nutrition
A forgotten Aztec scholar and more: Books in brief
The mystery of Feynman’s sprinkler is solved at last
Author Correction: Satellite mapping reveals extensive industrial activity at sea
Blood pressure pulsations modulate central neuronal activity via mechanosensitive ion channels
Science, Volume 383, Issue 6682, February 2024.
Whole-brain spatial organization of hippocampal single-neuron projectomes
Science, Volume 383, Issue 6682, February 2024.