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See raining iguanas and coral from the inside out — February’s best science images
US climate actions must continue, despite setbacks
From the first telephone to videoconferencing in 100 years
Genetically encoded assembly recorder temporally resolves cellular history
Author Correction: Healthy forests safeguard traditional wild meat food systems in Amazonia
Estropausal gut microbiota transplant improves measures of ovarian function in adult mice
Multi-tissue transcriptomic aging atlas reveals predictive aging biomarkers in the killifish
Advancing senescence translation through the Senotherapeutics Biomarker Consortium
How infighting led the Maya civilization to catastrophic collapse
Why ‘quantum proteins’ could be the next big thing in biology
Climate research is global — risks and responsibilities should also be distributed
South Korea’s AI framework act focuses on rights and safety
Releasing open-weight AI in steps would alleviate risks
Did ancient Greek priestesses brew a mind-bending potion drunk by Cicero and Marcus Aurelius?
Researchers found the psychedelic elixir would have been possible to make using ingredients and techniques available in ancient Greece
Stem cell therapies ‘come of age’ with two conditional approvals in Japan
Induced pluripotent stem cells could help treat diseased hearts and brains
Exercise alleviates cognitive dysfunction in Alzheimer's disease mice via skeletal muscle-derived extracellular vesicles that enhance plaque clearance by microglia
Exercise confers cognitive benefits in Alzheimer's disease (AD), yet the underlying mechanisms remain incompletely understood. Skeletal muscle functions as an endocrine organ that secretes myokines which affect the homeostasis of extra-muscular organs, including the brain. Here we found that swimming exercise promotes secretion of skeletal muscle-derived extracellular vesicles (SKM-EVs), which are subsequently taken up via pinocytosis by microglia. Gain-of-function and loss-of-function...
Targeting the FNIP2-SERCA2b axis improves metabolic and mitochondrial defects in Ataxia Telangiectasia
Ataxia telangiectasia (AT) is a rare multisystem disorder caused by the loss of functional ATM protein, leading to immunodeficiency, cancer predisposition, neurodegeneration, diabetes, heart failure, and premature aging. Although ATM's role as a sensor of DNA double-strand breaks (DSBs) is well established, the mechanisms underlying the diverse AT phenotypes remain incompletely understood, with evidence suggesting they extend beyond DSB sensing. Here, we uncover widespread glycogen accumulation...
OMICmAge is a multiomic biological aging clock using electronic medical records
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Intrinsic capacity and resilience in hospitalized older adults: a gender-stratified analysis of the PRIFOR score
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Comparison of 4 Frailty Measurements in Relation to Ageing, Physical Performance, and All-Cause Mortality
CONCLUSIONS AND IMPLICATIONS: This study showed that the performance of frailty instruments varies strongly by outcome of interest, sex, and age. This has implications for the choice of the frailty instrument to use in different clinical and research contexts.