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Heat-driven functional extinction of Caribbean Acropora corals from Florida’s Coral Reef
Science, Volume 390, Issue 6771, Page 361-366, October 2025.
Engineering high Pockels coefficients in thin-film strontium titanate for cryogenic quantum electro-optic applications
Science, Volume 390, Issue 6771, Page 390-393, October 2025.
Late-surviving New Mexican dinosaurs illuminate high end-Cretaceous diversity and provinciality
Science, Volume 390, Issue 6771, Page 400-404, October 2025.
Drought-induced peatland carbon loss exacerbated by elevated CO2 and warming
Science, Volume 390, Issue 6771, Page 367-370, October 2025.
Positive affective contagion in bumble bees
Science, Volume 390, Issue 6771, Page 377-380, October 2025.
Invasion impacts in terrestrial ecosystems: Global patterns and predictors
Science, Volume 390, Issue 6771, Page 381-385, October 2025.
Observation of the distribution of nuclear magnetization in a molecule
Science, Volume 390, Issue 6771, Page 386-389, October 2025.
Correcting the record on race and medicine
Science, Volume 390, Issue 6771, Page 341-341, October 2025.
Vaccinations for all
Science, Volume 390, Issue 6771, Page 342-342, October 2025.
At futuristic meeting, AIs took the lead in producing and reviewing all the studies
Organizers aim to tune AI to help accelerate science
Can the <em>Deadliest Catch</em> crab fishery survive warming seas?
After a brutal heat wave, scientists race to predict how Bering Sea snow crabs will cope with climate change
University of California faculty push back against Big Brother cybersecurity mandate
School officials defend software as bulwark against ransomware, but professors fear potential surveillance of their devices
Sumerian civilization may have been jump-started by the rise and fall of tides
Millennia before the first cities, early Mesopotamians probably harnessed tides to irrigate crops
Visualizing the chronicle of multiple cell fates using a near-IR dual-RNA/DNA-targeting probe
Early detection and late-stage cell fate assessment are key factors to develop therapeutic strategies, although current methods cannot capture early responses or distinguish multiple injury states, especially in ultraviolet-visible (UV-vis)-sensitive cells. Here, we introduce a method to simultaneously detect variations in RNA and DNA under near-infrared photoexcitation. Using a pyrazinacene-based probe (TEG(8)-N14), we unexpectedly achieved discrimination of multiple cell states, including...
Characterization of National Institute on Aging-Funded Clinical Trials for Alzheimer's Disease
No abstract
An optimized click chemistry method allows visualization of proliferating neuronal progenitors in the mouse brain
We establish a click reaction-based workflow (tissue clearing coupled with click-chemistry in 3D, C⁴-3D) to visualize 5-ethynyl-2'-deoxyuridine (EdU) in whole mouse brain tissue cleared by CUBIC, iDisco+, and PACT. C⁴-3D was compatible with immunostaining, nuclear staining, and a fluorescent reporter mouse. Machine learning-based identification of EdU-positive nuclear coordinates followed by normalization for the Allen Brain Atlas revealed that proliferating neuronal progenitors were enriched in...
Targeting VGLL4 maintains extracellular matrix homeostasis and mitigates osteoarthritis in a preclinical model
Extracellular matrix homeostasis is crucial for hyaline cartilage integrity, however, the mechanism of extracellular matrix homeostasis in hyaline cartilage is poorly understood. Single-cell sequencing shows that VGLL4 is highly expressed in chondrocytes but declines after injury/aging. VGLL4 deficiency impairs collagen/elastin formation, causes extracellular matrix disorganization and osteoarthritis in Col2-CreERT2; Vgll4^(fl/fl) mice, and is exacerbated by destabilization of the medial...
Tissue and cellular spatiotemporal dynamics in colon aging
Tissue structure and molecular circuitry in the colon can be profoundly impacted by systemic age-related effects but many of the underlying molecular cues remain unclear. Here, we build a cellular and spatial atlas of the colon across three anatomical regions and 11 age groups, encompassing ~1,500 mouse gut tissues profiled by spatial transcriptomics and ~400,000 single nucleus RNA-sequencing profiles. We develop a computational framework, cSplotch, which learns a hierarchical Bayesian model of...
Author Correction: Mitochondria-associated condensates maintain mitochondrial homeostasis and promote lifespan
No abstract
Comparative evaluation of relative fat mass and body mass index in predicting cardiometabolic multimorbidity in older adults: results from the English Longitudinal Study of Ageing
Relative fat mass (RFM) is a more accurate measure of body fat percentage than body mass index (BMI). However, its association with cardiometabolic multimorbidity (CMM) and its predictive value have not been examined. This study evaluated and compared the associations and predictive utility of RFM and BMI for CMM. We analyzed data from 3,348 adults (mean age 64 years; 45.1% male) in the English Longitudinal Study of Ageing who were free of hypertension, coronary heart disease, diabetes, and...