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Aging is characterized by progressive loss of physiological resilience accompanied by increased susceptibility to chronic diseases. Among the interconnected hallmarks of aging, cellular senescence has emerged as a central driver of systemic inflammation through the senescence-associated secretory phenotype (SASP). Senescent cells accumulate across multiple tissues with advancing age and secrete complex mixtures of cytokines, growth factors, and proteases that reshape tissue microenvironments and...

Heart failure with preserved ejection fraction (HFpEF) is a cardiometabolic syndrome strongly associated with aging, systemic inflammation and endothelial dysfunction, in which impaired endothelial nitric oxide synthase (eNOS) signaling plays a central role. This study aimed to identify circulating proteins associated with HFpEF and to explore their relationship with endothelial alterations under metabolic stress. A total of 109 HFpEF patients and 49 control subjects underwent clinical,...

CONCLUSIONS: Perceived age-based discrimination is associated with increased healthcare utilization among older adults in India through both direct and indirect pathways, with the indirect effect operating via probable depression and subsequent multimorbidity. These findings highlight the importance of addressing discrimination and integrating mental health within primary care, while also accounting for rural-urban disparities, to promote equitable healthcare access and improve health outcomes...

Aging is a major independent risk factor for the development and progression of metabolic dysfunction-associated steatotic liver disease (MASLD); however, effective therapeutic strategies for this population remain limited. Here, we established a model of aging-associated MASLD by subjecting aged mice to a long-term high-fat diet (HFD), which recapitulated key disease features including progressive hepatic steatosis, inflammation, insulin resistance, and fibrosis. A 6-week exercise intervention...

FAM162A is an inner mitochondrial protein known for its role in hypoxia-induced apoptosis. However, it is often overexpressed in cancer, where its pro-apoptotic function appears to be overridden, suggesting novel unknown roles in mitochondrial function and cell survival. Furthermore, its precise localization, topology, and orientation remain controversial. In this study, we aimed to assess the role of FAM162A in mitochondrial structure, dynamics, and bioenergetics and its impact on cellular and...

CONCLUSIONS: These findings support the conclusion that somatic symptoms may disproportionately inflate depression scores among patients with ovarian cancer at diagnosis, which may potentially lead to misclassification or overestimation of depression severity. This highlights the need for refined measurement approaches that account for the somatic burden of cancer in assessing depression during active disease.

Interpreting genome-wide epigenomic experiments, such as DNA methylation profiling and chromatin accessibility assays, requires tools that can identify which regulatory programs underlie coordinated changes across genomic regions. Without this regulatory context, lists of differential regions remain largely descriptive and difficult to interpret mechanistically. Existing approaches either apply hard significance cutoffs that discard moderate but biologically meaningful signals, or rely on...

Bizarre injuries were not caused by sharks or boat propellers, but a more surprising culprit

A major new analysis suggests semaglutide (Ozempic, Wegovy) works remarkably well in adults over 65, helping many lose substantial amounts of weight while improving heart and metabolic health. Participants taking the drug lost over 15% of their body weight on average — far more than those receiving placebo treatment. Many also moved out of obesity categories entirely and reached healthier weight levels.

A new study suggests AI chatbots may do more than spread misinformation — they can actively strengthen a user’s false beliefs. Because conversational AI often validates and builds on what users say, it can make distorted memories, conspiracy theories, or delusions feel more believable and emotionally real. Researchers warn that AI companions may be especially risky for isolated or vulnerable people seeking reassurance and connection.

An ancient Chinese exercise routine may be just as powerful as a daily brisk walk for lowering blood pressure — without equipment, gyms, or intense workouts. In a major clinical trial, adults with stage 1 hypertension who practiced baduanjin, a gentle mind-body exercise combining slow movements, breathing, and meditation, saw meaningful drops in blood pressure within three months that lasted for an entire year.