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Net-zero emissions commitments are more threatened than ever
Charles Darwin’s brilliance was continuously evolving
Author Correction: Virus-induced senescence is a driver and therapeutic target in COVID-19
Author Correction: GZMK-expressing CD8<sup>+</sup> T cells promote recurrent airway inflammatory diseases
Carbon monoxide blamed for deaths of 22 research monkeys at troubled supplier
USDA report hits Alpha Genesis with “critical” violation but agency says no discipline will follow
Asteroid impact on Moon carved massive canyons within minutes
Analysis of lunar photographs details ancient strike, provides optimism for future lunar missions
Amygdala stimulation transforms short-term memory into remote memory by persistent activation of atypical protein kinase C in the anterior cingulate cortex
Although many studies have addressed the role of the amygdala in modulating long-term memory, it is not known whether weak training plus amygdala stimulation can transform a short-term memory into a remote memory. Object place recognition (OPR) memory after strong training remains hippocampus-dependent through the persistent action of protein kinase Mzeta (PKMζ) for at least 6 days, but it is unknown whether weak training plus amygdala stimulation can transform short-term memory into an even...
Amygdala stimulation transforms short-term memory into remote memory by persistent activation of atypical protein kinase C in the anterior cingulate cortex
Although many studies have addressed the role of the amygdala in modulating long-term memory, it is not known whether weak training plus amygdala stimulation can transform a short-term memory into a remote memory. Object place recognition (OPR) memory after strong training remains hippocampus-dependent through the persistent action of protein kinase Mzeta (PKMζ) for at least 6 days, but it is unknown whether weak training plus amygdala stimulation can transform short-term memory into an even...
Association between sex steroid hormones and α-klotho: Results from the NHANES 2013-2016 and Mendelian randomization study
CONCLUSION: In conclusion, our results demonstrate that both TT and Bio-T enhance the expression of α-Klotho in men. The positive association observed may be partly mediated by uric acid and creatinine.
Individual and additive effects of vitamin D, omega-3 and exercise on DNA methylation clocks of biological aging in older adults from the DO-HEALTH trial
While observational studies and small pilot trials suggest that vitamin D, omega-3 and exercise may slow biological aging, larger clinical trials testing these treatments individually or in combination are lacking. Here, we report the results of a post hoc analysis among 777 participants of the DO-HEALTH trial on the effect of vitamin D (2,000 IU per day) and/or omega-3 (1 g per day) and/or a home exercise program on four next-generation DNA methylation (DNAm) measures of biological aging...
Omega-3 supplements slow biological ageing
No abstract
Mechanism for meeting the care of older adults in rural China-relying on spouse, offspring or community?
CONCLUSION: Our results indicate the meeting of the care needs among rural older adults is influenced by the quality of their spouse, offspring, and community, with these effects diminishing later in the life cycle.
Health Behaviors and Executive Function in Late Adulthood: A Time-Varying Effect Modeling Analysis
CONCLUSION: These results highlight sleep's importance for cognitive health and suggest interventions focusing on sleep and weight management to mitigate age-related cognitive decline.
Association of Longitudinal Trajectories of Physical Frailty With Dementia Status in Older Adults: A National Cohort Study
CONCLUSION AND IMPLICATIONS: This study highlighted the importance of regular frailty monitoring for early detection and informed future interventions that could delay frailty progression and potentially reduce dementia risk.
Application of the Uniform Data Set version 3 tele-adapted test battery (T-cog) for remote cognitive assessment preoperatively in older adults
INTRODUCTION: Older adults undergoing surgery are at risk of postoperative neurocognitive disorders, prompting the need for preoperative cognitive screening in this population. Traditionally, cognitive screening has been conducted in-person using brief assessment tools such as the Montreal Cognitive Assessment (MoCA) or the Mini-Mental State Examination (MMSE). More comprehensive test batteries, such as the Uniform Data Set (UDS) Neuropsychological Battery, and its remote testing version, the...
Intrinsic brain functional connectivity mediates the relationship between psychological resilience and cognitive decline in ageing
Ageing individuals often experience cognitive decline and intrinsic functional connectivity (FC) changes. Psychological resilience, a personality trait that reflects the capacity to adapt and cope with age-related challenges, plays a key role in mitigating cognitive decline. In this study involving 101 older adults, we investigated how psychological resilience influences cognitive decline measured by processing speed. Particularly, we obtained resting-state functional magnetic resonance imaging...
NIH eases freeze on grant reviews imposed after Trump communications pause
Meetings of study sections and closed portion of councils back on track as agency also deals with diversity-related executive orders