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Gut microbes play a crucial role in modulating host lifespan. However, the microbial factors that influence host longevity and their mechanisms of action remain poorly understood. Using the expression of Caenorhabditis elegans FAT-7, a stearoyl-CoA 9-desaturase, as a proxy for lifespan modulation, we conduct a genome-wide bacterial mutant screen and identify 26 Escherichia coli mutants that enhance host lifespan. Transcriptomic and biochemical analyses reveal that these mutant diets induce...

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Metabolic rewiring helps to construct efficient microbial cell factories; however, these cells suffer from metabolic stress during long-term fed-batch fermentation. Thus, the construction of robust cells is vital for industrial application of microbial cell factories at the laboratory scale. Here, we systematically characterized longevity factors and pathways for biosynthesis of the diterpenoid sclareol and found that weakening nutrient-sensing pathways and enhancing mitophagy synergistically...

People tend to form impressions of others' trustworthiness based on their facial appearance and make trust-related decisions accordingly. In such face-based trustworthiness judgments (FBTJs), older adults are generally more likely than younger adults to attribute higher trustworthiness. This pattern is sometimes referred to as positivity bias and has been proposed as a potential risk factor for fraud victimization in later life. However, previous studies lack objective ground-truth measures of...

Culling proceeds after Canada’s Supreme Court ends heated 11-month battle over the fate of more than 300 birds