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Accurate predictions of disordered protein ensembles with STARLING
The natural architecture of oyster reefs maximizes recruit survival
Rising atmospheric CO<sub>2</sub> reduces nitrogen availability in boreal forests
Giant energy storage and dielectric performance in all-polymer nanocomposites
This chunk of glass could store two million books for 10,000 years
Stereospecific alkyl–alkyl cross-coupling of boronic esters
Induction of senescence during postpartum mammary gland involution supports tissue remodeling and promotes postpartum tumorigenesis
Deepest-ever rock core extracted from under Antarctic ice sheet
Why China and Europe should collaborate to ‘defossilize’ the world’s carbon
Will self-driving ‘robot labs’ replace biologists? Paper sparks debate
How do autistic people age — and what does it mean for their health?
Mid-cycle update
Author Correction: <i>BCL6</i> enables Ph<sup>+</sup> acute lymphoblastic leukaemia cells to survive <i>BCR–ABL1</i> kinase inhibition
Musical chairs leadership shake-up planned for science agencies
CDC acting Director Jim O’Neill to be nominated to lead NSF while NIH Director Jay Bhattacharya does double duty at CDC
Highly destructive mussel has started to invade the Amazon
After ravaging waterways across South America, the fast-spreading species threatens a biodiversity stronghold
Squashed skulls found in China belong to first known East Asians
Revised dating of enigmatic Yunxian skulls pushes their age back 800,000 years, challenges idea of Denisovan ancestry
Author Correction: Perivascular cells induce microglial phagocytic states and synaptic engulfment via SPP1 in mouse models of Alzheimer's disease
No abstract
The Brain Resilience Study protocol: Building a dataset of the biological and sociocultural factors affecting brain health in older adults
Dementia arises from a complex interplay of biological, psychological, and sociocultural factors. However, previous large-scale studies have largely focused on biomarkers and genetics, with limited attention to the social and structural determinants of health that shape diverse aging trajectories. The Brain Resilience Study (BRS) addresses this gap by integrating multimodal biological and cognitive measures with rich demographic, psychosocial, and lifestyle data to create an open resource for...
FDA go-ahead to test cellular rejuvenation therapy in humans
No abstract
Coordinated control of proteasome subunit gene expression promotes stress resistance, proteostasis, and longevity
The proteasome is essential for cellular protein homeostasis through selective destruction of damaged and misfolded proteins. Failure of proteasome-dependent turnover accompanied by accumulation and aggregation of aberrant proteins is a hallmark of aging and late-onset neurodegenerative diseases. SKN-1A/Nrf1, a member of the NFE2L/Nrf family of transcription factors, is a master regulator of proteasome biogenesis. Through transcriptional control of proteasome subunit gene expression, SKN-1A/Nrf1...