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How billions of hacked mosquitoes and a vaccine could beat the deadly dengue virus
‘Revolutionary’ AI tools rescue old weather data to improve climate models
Mysterious mass deaths of an extinct giant deer
Gone with the wind: deciphering how dandelions drive seed dispersal
Publisher Correction: TCF1 and LEF1 promote B-1a cell homeostasis and regulatory function
Delta-type glutamate receptors are ligand-gated ion channels
How did assaults on science become the norm — and what can we do?
Coordinate to combat Pakistan’s climate-driven disasters
A population plunge could help to mitigate the global biodiversity crisis
Impoundment of funds endangers US investment in science and medical research
Fertility declines are no cause for concern, history shows
Notorious ex–weapons factory will lock up nuclear waste in glass—if the White House lets it
Hanford vitrification plant set to open but some fear Trump officials are pushing for a cheaper alternative
House panels charge U.S. National Academies with producing partisan studies
Pending spending bill urges agencies to find other sources of scientific advice
Satellites could reveal the secret burial grounds of Mexico’s murder victims
Sensors can detect chemical clues invisible to the human eye
Primary care detection of Alzheimer's disease using a self-administered digital cognitive test and blood biomarkers
After the clinical implementation of amyloid-β-targeting therapies for people with cognitive impairment due to Alzheimer's disease (AD), there is an urgent need to efficiently identify this patient population in primary care. Therefore, we created a brief and self-administered digital cognitive test battery (BioCog). Based on its sub-scores, a logistic regression model was developed in a secondary care cohort (n = 223) and then evaluated in an independent primary care cohort comprising 19...
Mice carrying the homologous human shelterin POT1-L259S mutation linked to pulmonary fibrosis show a telomerase deficiency-like phenotype with telomere shortening with increasing mouse generations
Pulmonary fibrosis is a lethal disease associated with damaging insults to the lung and with organismal aging. The presence of short and dysfunctional telomeres has been placed at the origin of this disease in a percentage of both familial and sporadic cases. Recently, a mutation in the telomere-binding protein protection of telomeres 1 in humans (hPOT1), the hPOT1 L259S mutation, was found in families with idiopathic pulmonary fibrosis. Here, we generated a Pot1a ^(L261S) knock-in mouse...
A blood DNA methylation test reveals how quickly each organ system is aging
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Age and sex modulate scapular muscle excitation strategies during loaded shoulder flexion
Age and sex are primary risk factors for shoulder pain, yet the underlying neuromuscular adaptations in scapular control are poorly understood, partly due to methodological inconsistencies in prior research, particularly in load standardization. This study aimed to define age- and sex-related differences in scapular muscle excitation during a shoulder flexion task with a standardized relative load. Fifty-two healthy younger (18-39y) and older (60-74y) males and females performed shoulder flexion...
Directing selective solvent presentations at electrochemical interfaces to enable initially anode-free sodium metal batteries
Initially anode-free sodium metal batteries offer a high energy density at lower costs than lithium-ion batteries, making them a promising alternative for portable electronics, transportation, and power grids. However, side reactions at the electrode/electrolyte interface hinder their practical applications. Our study reveals that negative electrode stability is primarily influenced by the solvents in the cation's first solvation shell, whereas positive electrode stability is dictated by weakly...
Advancing biological understanding of cellular senescence with computational multiomics
Cellular senescence is a complex biological process that plays a pathophysiological role in aging and age-related diseases. The biological understanding of senescence at the cellular and tissue levels remains incomplete due to the lack of specific biomarkers as well as the relative rarity of senescent cells, their phenotypic heterogeneity and dynamic features. This Review provides a comprehensive overview of multiomic approaches for the characterization and biological understanding of cellular...