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FDA to approve leucovorin despite questions about whom it might help

Large language models could help reduce backlog of study proposals, but critics are wary of entrusting ethics to machines

Judge says district court is proper forum to protest mass grant terminations

Confidential data show being in the U.S., at a prestigious institution, and in a large team all may help

Hesperidin is a flavonoid renowned for its significant pharmacological effects and promising therapeutic potential. It is ubiquitous in the plant kingdom and is a common constituent of our daily diets, primarily in fruits and vegetables. Several cellular and animal models have been developed to evaluate the underlying neuropharmacological mechanisms of hesperidin. Additionally, clinical evidence has also confirmed itsneuroprotectivefunction. Hesperidin exerts neuroprotective properties by...

Parkinson's disease (PD) is a neurodegenerative disorder with a worldwide prevalence of around 9.4 million that is expected to double by 2040. It's extended prodromal phase allows irreversible neuronal loss to occur before manifestation of symptoms. Current diagnostic approaches, primarily based on clinical assessment and neuroimaging, are often delayed and lack sensitivity in the early stages, highlighting the need for an early, conclusive, and minimally invasive test. This review focuses on...

Lipid alterations in the brain have been implicated in many neurodegenerative diseases. To facilitate comparative lipidomic research across brain diseases, we establish a data common named the Neurolipid Atlas that we prepopulated with isogenic induced pluripotent stem cell (iPS cell)-derived lipidomics data for different brain diseases. Additionally, the resource contains lipidomics data of human and mouse brain tissue. Leveraging multiple datasets, we demonstrate that iPS cell-derived neurons,...

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Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative condition characterized by rapid degeneration of motoneurons (MNs), leading to progressive muscle atrophy and, ultimately, mortality within a few years of diagnosis. Although the precise mechanisms initiating MN degeneration are not fully understood, the involvement of non-neuronal cells, including microglia, in ALS pathophysiology is increasingly recognized. Mesenchymal stromal cell (MSC)-based therapies have emerged as a...

CONCLUSION: Parents of migrants often experience poorer health, chronic morbidity, psychological distress, and loneliness compared to parents of non-migrants. Despite family members being primary caregivers, parents of migrants were more likely to rely on non-family caregivers and take on financial responsibility for their care. The study highlights the need for eldercare strategies to address the caregiving gaps in areas with high adult out-migration, particularly considering generational and...