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ApoD mediates age-associated increase in vulnerability to influenza virus infection

2 months 2 weeks ago
Influenza A virus (IAV) infection causes significantly greater morbidity and mortality in the elderly population, but the molecular mechanisms in the aging process responsible for severe infection remain unclear. In this study, we found that increased severity in IAV infection and reduced innate immune response correlated with extensive mitophagy in senescent human cells and in the lung of aged mice. Apolipoprotein D (ApoD) was identified as strongly elevated in the lungs and sera of aged human...
Zhimin Jiang

Entropy, Assessed by Homeostatic Dysregulation on Electrocardiograms Predicts Fracture and Mortality

2 months 2 weeks ago
Entropy, characterized by increased disorder throughout biological systems, can be quantified by homeostatic dysregulation (HD). One potential measure of HD is the dispersion of points from a normal value, approximated at the individual level by Mahalanobis distance (D(M)). We hypothesized that greater HD in electrocardiogram (ECG) would also reflect greater HD in the musculoskeletal system which, in turn, would be associated with age and manifest as an increased risk of fracture independently...
Namki Hong

Visual objects refine head direction coding

2 months 2 weeks ago
Science, Volume 389, Issue 6765, September 2025.
Dominique Siegenthaler, Henry Denny, Sofía Skromne Carrasco, Johanna Luise Mayer, Daniel Levenstein, Adrien Peyrache, Stuart Trenholm, Émilie Macé

In Science Journals

2 months 2 weeks ago
Science, Volume 389, Issue 6765, Page 1103-1105, September 2025.
Michael Funk, and Bianca Lopez, L. Bryan Ray, Brandon Berry, Jake S. Yeston, Jelena Stajic, Colleen McBride, Marc S. Lavine, Sacha Vignieri, Mattia Maroso, Stella M. Hurtley, Madeleine Seale, Di Jiang, Peter Stern, Jesse Smith, Corinne Simonti, Leslie…