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Light-driven nanoscale vectorial currents
A break in mitochondrial endosymbiosis as a basis for inflammatory diseases
Naturally occurring T cell mutations enhance engineered T cell therapies
Identification of direct connections between the dura and the brain
Circulating myeloid-derived MMP8 in stress susceptibility and depression
Cancer’s power harnessed — lymphoma mutations supercharge T cells
The new car batteries that could power the electric vehicle revolution
Roman-era bone container holds potent, hallucinogenic medicine
Researchers found a cache of black henbane seeds in an outpost far from the empire’s learning centers
European Parliament votes to ease regulation of gene-edited crops
Move is a major victory for biotechnology, but debate remains over patents and labels
U.S. Census Bureau scraps proposed changes to disability questions
Abandoned plan would have drastically decreased the number of people in the U.S. who are considered disabled
Aneuploidy-induced cellular behaviors: Insights from Drosophila
A balanced gene complement is crucial for proper cell function. Aneuploidy, the condition of having an imbalanced chromosome set, alters the stoichiometry of gene copy numbers and protein complexes and has dramatic consequences at the cellular and organismal levels. In humans, aneuploidy is associated with different pathological conditions including cancer, microcephaly, mental retardation, miscarriages, and aging. Over the last century, Drosophila has provided a valuable system for studying the...
Senolytics: from pharmacological inhibitors to immunotherapies, a promising future for patients' treatment
The involvement of cellular senescence in the initiation and propagation of diseases is clearly characterized, making the elimination of senescent cells essential to treat age-related diseases. The development of senolytic drugs demonstrated that targeting these cells limits the deterioration of patients' condition, by inducing apoptosis. Nevertheless, the first generations of senolytics which has been developed displayed their activities through specific mechanisms and demonstrated several...
Petal abscission is promoted by jasmonic acid-induced autophagy at Arabidopsis petal bases
In angiosperms, the transition from floral-organ maintenance to abscission determines reproductive success and seed dispersion. For petal abscission, cell-fate decisions specifically at the petal-cell base are more important than organ-level senescence or cell death in petals. However, how this transition is regulated remains unclear. Here, we identify a jasmonic acid (JA)-regulated chromatin-state switch at the base of Arabidopsis petals that directs local cell-fate determination via autophagy....
Therapeutic targeting of cellular senescence in diabetic macular edema: preclinical and phase 1 trial results
Compromised vascular endothelial barrier function is a salient feature of diabetic complications such as sight-threatening diabetic macular edema (DME). Current standards of care for DME manage aspects of the disease, but require frequent intravitreal administration and are poorly effective in large subsets of patients. Here we provide evidence that an elevated burden of senescent cells in the retina triggers cardinal features of DME pathology and conduct an initial test of senolytic therapy in...
Age-, sex- and proximal-distal-resolved multi-omics identifies regulators of intestinal aging in non-human primates
The incidence of intestinal diseases increases with age, yet the mechanisms governing gut aging and its link to diseases, such as colorectal cancer (CRC), remain elusive. In this study, while considering age, sex and proximal-distal variations, we used a multi-omics approach in non-human primates (Macaca fascicularis) to shed light on the heterogeneity of intestinal aging and identify potential regulators of gut aging. We explored the roles of several regulators, including those from tryptophan...
Decoding regulators of gut aging in nonhuman primates
No abstract
Older adults preserve audiovisual integration through enhanced cortical activations, not by recruiting new regions
Effective interactions with the environment rely on the integration of multisensory signals: Our brains must efficiently combine signals that share a common source, and segregate those that do not. Healthy ageing can change or impair this process. This functional magnetic resonance imaging study assessed the neural mechanisms underlying age differences in the integration of auditory and visual spatial cues. Participants were presented with synchronous audiovisual signals at various degrees of...